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[ "Proline", "-rich", "antimicrobial", "peptides", "targeting", "protein", "synthesis", "Covering:", "up", "to", "2017The", "innate", "immune", "system", "employs", "a", "broad", "array", "of", "antimicrobial", "peptides", "(AMPs)", "to", "attack", "invading", "microorganisms.", "While", "most", "AMPs", "act", "by", "permeabilizing", "the", "bacterial", "membrane,", "specific", "subclasses", "of", "AMPs", "have", "been", "identified", "that", "pass", "through", "membranes", "and", "inhibit", "bacterial", "growth", "by", "targeting", "fundamental", "intracellular", "processes.", "One", "such", "subclass", "is", "the", "proline", "-rich", "antimicrobial", "peptides", "(PrAMPs)", "that", "bind", "to", "the", "ribosome", "and", "interfere", "with", "the", "process", "of", "protein", "synthesis.", "A", "diverse", "range", "of", "PrAMPs", "have", "been", "identified", "in", "insects,", "such", "as", "bees,", "wasps", "and", "beetles,", "and", "crustaceans,", "such", "as", "crabs,", "as", "well", "as", "in", "mammals,", "such", "as", "cows,", "sheep,", "goats", "and", "pigs.", "Mechanistically,", "the", "best-characterized", "PrAMPs", "are", "the", "insect", "oncocins,", "such", "as", "Onc112,", "and", "bovine", "bactenecins,", "such", "as", "Bac7.", "Biochemical", "and", "structural", "studies", "have", "revealed", "that", "these", "PrAMPs", "bind", "within", "the", "ribosomal", "exit", "tunnel", "with", "a", "reverse", "orientation", "compared", "to", "a", "nascent", "polypeptide", "chain.", "The", "PrAMPs", "allow", "initiation", "but", "prevent", "the", "transition", "into", "the", "elongation", "phase", "of", "translation.", "Insight", "into", "the", "interactions", "of", "PrAMPs", "with", "their", "ribosomal", "target", "provides", "the", "opportunity", "to", "further", "develop", "these", "peptides", "as", "novel", "antimicrobial", "agents." ]

[ 1, 0, 1, 2, 1, 1, 2, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 1, 0, 1, 2, 1, 0, 1, 1, 2, 0, 0, 1, 0, 0, 1, 0, 1, 1, 0, 1, 0, 1, 0, 0, 1, 0, 0, 0, 1, 0, 1, 1, 1, 0, 1, 0, 1, 2, 0, 0, 1, 0, 0, 1, 0, 1, 2, 1, 0, 1, 0, 0, 1, 0, 1, 2, 0, 1, 0, 1, 2, 0, 0, 0, 0, 1, 0, 0, 1, 0, 1, 0, 0, 1, 1, 0, 1, 0, 1, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 1, 1, 1, 0, 1, 0, 0, 1, 1, 0, 0, 1, 1, 0, 0, 1, 0, 1, 1, 0, 0, 1, 1, 0, 1, 2, 0, 1, 0, 0, 1, 1, 0, 0, 1, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 1, 2, 0, 1, 0, 1, 0, 1, 0, 1, 0, 0, 1, 1, 0, 1, 0, 0, 0, 1, 0, 1, 0, 0, 1, 1, 1, 0, 0, 0, 1, 0, 0, 1, 0, 1, 1, 2 ]

[ "Organophosphate", "Esters", "in", "Air,", "Snow", "and", "Seawater", "in", "the", "North", "Atlantic", "and", "the", "Arctic", "The", "concentrations", "of", "eight", "organophosphate", "esters", "(OPEs)", "have", "been", "investigated", "in", "air,", "snow", "and", "seawater", "samples", "collected", "during", "the", "cruise", "of", "ARK-XXVIII/2", "from", "6th", "June", "to", "3rd", "July", "2014", "across", "the", "North", "Atlantic", "and", "the", "Arctic.", "The", "sum", "of", "gaseous", "and", "particle", "concentrations", "(∑OPE)", "ranged", "from", "35", "to", "343", "pg/m3.", "The", "three", "chlorinated", "OPEs", "accounted", "for", "88", "±", "5%", "of", "the", "∑OPE.", "The", "most", "abundant", "OPE", "was", "tris-(2-chloroethyl)", "phosphate", "(TCEP),", "with", "concentrations", "ranging", "from", "30", "to", "227", "pg/m3,", "followed", "by", "three", "major", "OPEs,", "such", "as", "tris-(1-chloro-2-propyl)", "phosphate", "(TCPP,", "0.8", "to", "82", "pg/m3),", "tri-n-butyl", "phosphate", "(TnBP,", "2", "to", "19", "pg/m3)", "and", "tri-iso-butyl", "phosphate", "(TiBP,", "0.3", "to", "14", "pg/m3).", "The", "∑OPE", "concentrations", "in", "snow", "and", "seawater", "ranged", "from", "4356", "to", "10561", "pg/L", "and", "from", "348", "to", "8396", "pg/L,", "respectively.", "The", "atmospheric", "particle", "-bound", "dry", "depositions", "of", "TCEP", "ranged", "from", "2", "to", "12", "ng/m2/day.", "The", "air", "-", "seawater", "gas", "exchange", "fluxes", "were", "dominated", "by", "net", "volatilization", "from", "seawater", "to", "air", "for", "TCEP", "(mean,", "146", "±", "239", "ng/m2/day),", "TCPP", "(mean,", "1670", "±", "3031", "ng/m2/day),", "TiBP", "(mean,", "537", "±", "581", "ng/m2/day)", "and", "TnBP", "(mean,", "230", "±", "254", "ng/m2/day).", "This", "study", "highlighted", "that", "OPEs", "are", "subject", "to", "long-range", "transport", "via", "both", "air", "and", "seawater", "from", "the", "European", "continent", "and", "seas", "to", "the", "North", "Atlantic", "and", "the", "Arctic." ]

[ 1, 2, 0, 1, 1, 0, 1, 0, 0, 1, 2, 0, 0, 1, 0, 1, 0, 0, 1, 2, 1, 0, 0, 0, 0, 1, 1, 0, 1, 1, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 0, 1, 0, 1, 0, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 1, 0, 1, 2, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 1, 0, 0, 0, 0, 1, 2, 1, 0, 0, 0, 0, 0, 1, 2, 1, 0, 0, 0, 0, 0, 1, 1, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 1, 2, 2, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 2, 0, 0, 1, 0, 1, 0, 0, 1, 1, 0, 1, 0, 0, 1, 2, 0, 0, 1 ]

[ "Ghrelin", "Protects", "the", "Thymic", "Epithelium", "From", "Conditioning-Regimen", "-", "Induced", "Damage", "and", "Promotes", "the", "Restoration", "of", "CD4+", "T", "Cells", "in", "Mice", "After", "Bone", "Marrow", "Transplantation", "The", "delay", "in", "immune", "reconstitution", "after", "hematopoietic", "stem", "cell", "transplantation", "(HSCT),", "especially", "a", "delay", "in", "central", "immune", "reconstitution,", "leads", "to", "opportunistic", "infections", "and", "disease", "relapse", "after", "transplantation", "and", "affects", "the", "long-term", "outcome", "of", "HSCT.", "This", "delay", "is", "mainly", "attributable", "to", "thymic", "damage", "after", "myeloablative", "chemotherapy", "and", "radiotherapy", "METHODS:", "We", "established", "a", "model", "of", "allogeneic", "bone", "marrow", "transplantation", "(BMT)", "in", "mice", "and", "administered", "ghrelin", "(GRL)", "7", "days", "before", "the", "conditioning", "regimen", "or", "the", "day", "after", "BMT.", "All", "the", "GRL", "-", "treated", "mice,", "especially", "those", "administered", "GRL", "prior", "to", "the", "conditioning", "regimen,", "exhibited", "more", "intact", "thymic", "architecture", "and", "a", "more", "rapid", "restoration", "of", "CD4", "T", "lymphocytes", "after", "BMT", "than", "those", "of", "the", "corresponding", "control", "mice.", "Moreover,", "the", "levels", "of", "T", "cell", "receptor", "excision", "circles", "(TRECs)", "were", "significantly", "higher", "in", "the", "mice", "treated", "with", "GRL", "prior", "to", "the", "conditioning", "regimen", "than", "in", "the", "control", "mice", "at", "28", "days", "after", "BMT.", "Our", "finding", "s", "suggest", "that", "GRL", "may", "be", "a", "novel", "potential", "therapeutic", "approach", "to", "protecting", "the", "thymic", "epithelium", "from", "conditioning-regimen", "-", "induced", "damage", "and", "promoting", "rapid", "and", "durable", "thymic", "and", "peripheral", "CD4", "T", "cell", "recovery", "after", "HSCT." ]

[ 1, 1, 0, 1, 2, 0, 1, 0, 1, 1, 0, 1, 0, 1, 0, 1, 2, 2, 0, 1, 0, 1, 2, 2, 0, 1, 0, 1, 2, 0, 1, 2, 2, 2, 1, 0, 0, 1, 0, 0, 1, 2, 0, 0, 1, 2, 0, 1, 2, 0, 1, 0, 0, 0, 1, 1, 0, 1, 0, 1, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 1, 0, 0, 1, 0, 0, 0, 1, 1, 2, 2, 1, 0, 1, 0, 1, 1, 1, 0, 1, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0, 0, 1, 0, 1, 1, 0, 0, 1, 1, 0, 0, 0, 1, 2, 0, 0, 0, 1, 0, 0, 0, 0, 1, 1, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 1, 2, 2, 2, 2, 1, 0, 1, 2, 0, 0, 1, 1, 2, 1, 0, 0, 0, 1, 2, 0, 0, 0, 1, 1, 0, 0, 1, 0, 1, 0, 1, 0, 0, 0, 1, 0, 0, 0, 1, 1, 1, 0, 0, 0, 0, 1, 1, 0, 1, 0, 1, 1, 0, 0, 1, 0, 0, 1, 0, 1, 1, 2, 2, 1, 0, 1 ]

[ "The", "regulation", "and", "adoption", "of", "health", "technologies", "under", "Brazil's", "Unified", "Health", "System:", "barriers", "to", "access", "to", "medicines", "for", "diseases", "of", "poverty?", "The", "study", "aimed", "to", "examine", "the", "regulation", "and", "adoption", "of", "health", "technologies", "for", "the", "diseases", "of", "poverty", "in", "the", "Brazil's", "Unified", "Health", "System", "(SUS).", "An", "exploratory,", "descriptive", "study", "was", "conducted", "between", "January", "and", "May", "2016", "consisting", "of", "the", "search", "and", "analysis", "of", "relevant", "documents", "on", "the", "websites", "of", "Brazil's", "National", "Health", "Surveillance", "Agency,", "the", "U.S.", "Food", "and", "Drug", "Administration", "(FDA),", "the", "European", "Medicines", "Agency", "(EMA),", "the", "National", "Commission", "for", "the", "Adoption", "of", "Technologies", "by", "the", "SUS,", "and", "Saúde", "Legis", "(the", "Ministry", "of", "Health's", "Legislation", "System).", "The", "2014", "version", "of", "the", "Brazilian", "National", "List", "of", "Essential", "Medicines", "(RENAME,", "acronym", "in", "Portuguese)", "contained", "132", "medicines", "for", "diseases", "of", "poverty.", "Over", "one-third", "of", "these", "(49)", "had", "only", "one", "national", "producer,", "while", "24", "were", "not", "registered", "in", "the", "country.", "The", "number", "of", "medicines", "contained", "in", "the", "RENAME", "dedicated", "to", "this", "group", "of", "diseases", "increased", "by", "46%", "between", "2006", "and", "2014.", "Despite", "advances", "in", "the", "regulation", "and", "incorporation", "of", "technologies", "by", "the", "SUS,", "given", "the", "lack", "of", "market", "interest", "and", "neglect", "of", "diseases", "of", "poverty,", "the", "government", "has", "a", "vital", "role", "to", "play", "in", "ensuring", "access", "to", "the", "best", "available", "therapies", "in", "order", "to", "reduce", "health", "inequalities.", "It", "therefore", "follows", "that", "Brazil", "needs", "to", "improve", "the", "regulation", "of", "medicines", "that", "do", "not", "attract", "market", "interest." ]

[ 0, 1, 0, 0, 0, 1, 2, 0, 1, 1, 2, 2, 0, 0, 0, 0, 1, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 2, 0, 0, 1, 0, 1, 0, 0, 1, 1, 2, 2, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 2, 2, 2, 0, 1, 2, 2, 2, 2, 1, 0, 1, 2, 2, 1, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 1, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 1, 0, 0, 1, 1, 2, 2, 2, 2, 1, 0, 0, 1, 0, 0, 1, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 1, 0, 0, 0, 1, 0, 0, 0, 1, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 1, 0, 1, 0, 0, 1, 0, 0, 1, 0, 1, 1, 0, 0, 0, 1, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 1, 1, 0, 1, 0, 1, 0, 1, 0, 0, 0, 0, 1, 1 ]

[ "Fatigue", "in", "multiple", "sclerosis:", "Associations", "with", "clinical,", "MRI", "and", "CSF", "parameters", "Damage", "of", "different", "brain", "structures", "has", "been", "related", "to", "fatigue.", "Alternatively,", "functional", "alterations", "of", "central", "nervous", "system", "(CNS)", "cells", "by", "the", "inflammatory", "milieu", "within", "the", "CNS", "may", "be", "responsible", "for", "the", "development", "of", "fatigue.", "To", "investigate", "the", "effect", "of", "structural", "brain", "damage", "and", "inflammatory", "cerebrospinal", "fluid", "(CSF)", "changes", "on", "fatigue", "in", "multiple", "sclerosis", "(MS).", "We", "determined", "the", "association", "of", "different", "clinical,", "CSF", "and", "magnetic", "resonance", "imaging", "(MRI)", "parameters", "with", "prevalence", "and", "severity", "of", "fatigue,", "as", "measured", "by", "the", "Fatigue", "Scale", "for", "Motor", "and", "Cognitive", "Functions", "in", "68", "early", "MS", "patients", "(discovery", "cohort).", "We", "validated", "our", "findings", "in", "two", "MS", "cohorts:", "the", "MRI", "validation", "cohort", "(N", "=", "233)", "for", "the", "clinical", "and", "MRI", "parameters,", "and", "the", "CSF", "validation", "cohort", "(N", "=", "81)", "for", "the", "clinical", "and", "CSF", "parameters.", "Fatigue", "was", "associated", "with", "clinical", "disability.", "Fatigue", "did", "not", "correlate", "with", "any", "CSF", "parameter", "but", "correlated", "negatively", "with", "total", "and", "cortical", "grey", "matter", "volume.", "However,", "when", "controlling", "for", "Expanded", "Disability", "Status", "Scale", "(EDSS)", "in", "a", "multivariate", "model,", "these", "associations", "lost", "significance.", "Disability", "and", "disease", "duration", "best", "explain", "fatigue", "severity", "but", "none", "of", "the", "tested", "MRI", "or", "CSF", "parameter", "was", "reliably", "associated", "with", "fatigue." ]

[ 1, 0, 1, 2, 1, 0, 1, 1, 0, 1, 1, 1, 0, 0, 1, 2, 0, 0, 1, 0, 1, 0, 1, 1, 0, 1, 2, 2, 1, 1, 0, 0, 1, 1, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 1, 0, 1, 0, 1, 2, 1, 1, 2, 0, 1, 1, 2, 1, 1, 0, 1, 0, 1, 2, 1, 0, 0, 0, 1, 0, 0, 1, 1, 0, 1, 2, 2, 1, 1, 0, 1, 0, 1, 0, 1, 0, 1, 0, 0, 1, 2, 2, 2, 2, 2, 2, 0, 0, 1, 1, 1, 1, 2, 0, 0, 0, 1, 0, 0, 1, 1, 0, 1, 1, 2, 0, 0, 0, 0, 0, 1, 0, 1, 1, 0, 0, 1, 1, 2, 0, 0, 0, 0, 0, 1, 0, 1, 1, 1, 0, 1, 2, 1, 1, 1, 0, 1, 1, 0, 0, 1, 1, 0, 1, 1, 0, 1, 0, 1, 1, 2, 1, 0, 0, 1, 0, 1, 2, 2, 2, 1, 0, 0, 1, 1, 0, 1, 1, 1, 1, 0, 1, 1, 0, 0, 1, 1, 0, 0, 0, 0, 1, 1, 0, 1, 1, 0, 0, 1, 2, 1 ]

[ "Intranasal", "Insulin", "Prevents", "Anesthesia", "-", "Induced", "Cognitive", "Impairment", "and", "Chronic", "Neurobehavioral", "Changes", "General", "anesthesia", "increases", "the", "risk", "for", "cognitive", "impairment", "post", "operation,", "especially", "in", "the", "elderly", "and", "vulnerable", "individuals.", "Recent", "animal", "studies", "on", "the", "impact", "of", "anesthesia", "on", "postoperative", "cognitive", "impairment", "have", "provided", "some", "valuable", "insights,", "but", "much", "remains", "to", "be", "understood.", "Here,", "by", "using", "mice", "of", "various", "ages", "and", "conditions,", "we", "found", "that", "anesthesia", "with", "propofol", "and", "sevoflurane", "caused", "significant", "deficits", "in", "spatial", "learning", "and", "memory,", "as", "tested", "using", "Morris", "Water", "Maze", "(MWM)", "2-6", "days", "after", "anesthesia", "exposure,", "in", "aged", "(17-18", "months", "old)", "wild-type", "(WT)", "mice", "and", "in", "adult", "(7-8", "months", "old)", "3xTg-AD", "mice", "(a", "triple", "transgenic", "mouse", "model", "of", "Alzheimer's", "disease", "(AD)),", "but", "not", "in", "adult", "WT", "mice.", "Anesthesia", "resulted", "in", "long-term", "neurobehavioral", "changes", "in", "the", "fear", "conditioning", "task", "carried", "out", "65", "days", "after", "exposure", "to", "anesthesia", "in", "3xTg-AD", "mice.", "Importantly,", "daily", "intranasal", "administration", "of", "insulin", "(1.75", "U/", "mouse", "/", "day)", "for", "only", "3", "days", "prior", "to", "anesthesia", "completely", "prevented", "the", "anesthesia", "-", "induced", "deficits", "in", "spatial", "learning", "and", "memory", "and", "the", "long-term", "neurobehavioral", "changes", "tested", "65", "days", "after", "exposure", "to", "anesthesia", "in", "3xTg-AD", "mice.", "These", "results", "indicate", "that", "aging", "and", "AD", "-like", "brain", "pathology", "increase", "the", "vulnerability", "to", "cognitive", "impairment", "after", "anesthesia", "and", "that", "intranasal", "treatment", "with", "insulin", "can", "prevent", "anesthesia", "-", "induced", "cognitive", "impairment." ]

[ 1, 1, 1, 1, 0, 1, 1, 2, 0, 1, 1, 2, 1, 2, 1, 0, 1, 0, 1, 2, 1, 2, 0, 0, 0, 1, 0, 1, 2, 1, 1, 2, 0, 0, 1, 0, 1, 0, 1, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 1, 0, 0, 0, 1, 0, 1, 0, 1, 0, 1, 1, 2, 2, 2, 2, 2, 0, 0, 0, 1, 2, 2, 1, 0, 1, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 1, 0, 1, 2, 1, 0, 0, 0, 0, 1, 2, 1, 0, 0, 1, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 2, 0, 1, 2, 0, 0, 1, 2, 0, 1, 0, 0, 1, 0, 1, 0, 0, 0, 1, 0, 0, 1, 0, 1, 0, 1, 0, 1, 1, 2, 2, 2, 2, 2, 0, 0, 1, 1, 2, 0, 0, 1, 0, 1, 2, 2, 0, 1, 2, 0, 1, 0, 0, 1, 0, 1, 0, 1, 2, 1, 0, 1, 0, 1, 2, 0, 1, 0, 0, 1, 2, 0, 1, 0, 1, 1, 0, 1, 1, 2 ]

[ "Effects", "of", "robot-assisted", "upper", "limb", "rehabilitation", "in", "stroke", "patients:", "a", "systematic", "review", "with", "meta-analysis", "Technology-supported", "training", "is", "emerging", "as", "a", "solution", "to", "support", "therapists", "in", "their", "efforts", "providing", "high-intensity,", "repetitive,", "and", "task-specific", "treatment,", "in", "order", "to", "enhance", "the", "recovery", "process.", "The", "aim", "of", "this", "review", "is", "to", "assess", "the", "effectiveness", "of", "different", "robotic", "devices", "(end-effector", "and", "exoskeleton", "robots)", "in", "comparison", "with", "any", "other", "type", "of", "intervention.", "Furthermore,", "we", "aim", "to", "assess", "whether", "or", "not", "better", "improvements", "are", "obtained", "in", "the", "sub-acute", "phase", "after", "stroke", "onset", "than", "in", "the", "chronic", "phase.", "A", "research", "was", "conducted", "in", "the", "electronic", "bibliographic", "databases", "Cochrane,", "MEDLINE,", "and", "EMBASE.", "A", "total", "of", "17", "studies", "were", "included:", "14", "randomized", "controlled", "trials,", "2", "systematic", "reviews,", "and", "one", "meta-analysis.", "Fugl-Meyer", "and", "modified", "Ashworth", "scale", "were", "selected", "to", "measure", "primary", "outcomes,", "i.e.,", "motor", "function", "and", "muscle", "tone.", "Functional", "independence", "measure", "and", "motor", "activity", "log", "were", "selected", "to", "measure", "secondary", "outcomes,", "i.e.,", "activities", "of", "daily", "living.", "In", "comparison", "with", "conventional", "therapy,", "the", "robot-assisted", "rehabilitation", "is", "more", "effective", "in", "improving", "upper", "limb", "motor", "function", "recovery,", "especially", "in", "chronic", "stroke", "patients.", "No", "significant", "improvements", "are", "observed", "in", "the", "reduction", "of", "muscle", "tone", "or", "daily", "living", "activities.", "The", "present", "systematic", "review", "shows", "that", "the", "use", "of", "robotic", "devices", "can", "positively", "affect", "the", "recovery", "of", "arm", "function", "in", "patients", "with", "stroke." ]

[ 0, 0, 1, 2, 2, 2, 0, 1, 1, 0, 1, 2, 0, 1, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 1, 1, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 1, 0, 1, 2, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 1, 0, 0, 0, 1, 2, 0, 1, 0, 0, 0, 0, 1, 2, 2, 1, 1, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 1, 2, 2, 0, 1, 2, 0, 0, 1, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 1, 2, 1, 2, 2, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 2, 0, 1, 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 1, 1, 2, 1, 2, 1, 0, 0, 1, 2, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 2, 2, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0, 1, 2, 0, 1, 0, 1 ]

[ "Daily", "stressors,", "trauma", "exposure,", "and", "mental", "health", "among", "stateless", "Rohingya", "refugees", "in", "Bangladesh", "The", "Rohingya", "of", "Myanmar", "are", "a", "severely", "persecuted", "minority", "who", "form", "one", "of", "the", "largest", "groups", "of", "stateless", "people;", "thousands", "of", "them", "reside", "in", "refugee", "camps", "in", "southeastern", "Bangladesh.", "There", "has", "been", "little", "research", "into", "the", "mental", "health", "consequences", "of", "persecution,", "war,", "and", "other", "historical", "trauma", "endured", "by", "the", "Rohingya;", "nor", "has", "the", "role", "of", "daily", "environmental", "stressors", "associated", "with", "continued", "displacement,", "statelessness,", "and", "life", "in", "the", "refugee", "camps,", "been", "thoroughly", "researched.", "This", "cross-sectional", "study", "examined:", "trauma", "history,", "daily", "environmental", "stressors,", "and", "mental", "health", "outcomes", "for", "148", "Rohingya", "adults", "residing", "in", "Kutupalong", "and", "Nayapara", "refugee", "camps", "in", "Bangladesh.", "Results", "indicated", "high", "levels", "of", "mental", "health", "concerns:", "posttraumatic", "stress", "disorder", "(PTSD),", "depression,", "somatic", "complaints,", "and", "associated", "functional", "impairment.", "Participants", "also", "endorsed", "local", "idioms", "of", "distress,", "including", "somatic", "complaints", "and", "concerns", "associated", "with", "spirit", "possession.", "The", "study", "also", "found", "very", "high", "levels", "of", "daily", "environmental", "stressors", "associated", "with", "life", "in", "the", "camps,", "including", "problems", "with", "food,", "lack", "of", "freedom", "of", "movement,", "and", "concerns", "regarding", "safety.", "Regression", "and", "associated", "mediation", "analyses", "indicated", "that,", "while", "there", "was", "a", "direct", "effect", "of", "trauma", "exposure", "on", "mental", "health", "outcomes", "(PTSD", "symptoms),", "daily", "environmental", "stressors", "partially", "mediated", "this", "relationship.", "Depression", "symptoms", "were", "associated", "with", "daily", "stressors,", "but", "not", "prior", "trauma", "exposure.", "These", "findings", "indicate", "that", "daily", "stressors", "play", "a", "pivotal", "role", "in", "mental", "health", "outcomes", "of", "populations", "affected", "by", "collective", "violence", "and", "statelessness.", "It", "is,", "therefore,", "important", "to", "consider", "the", "role", "and", "effects", "of", "environmental", "stressors", "associated", "with", "life", "in", "refugee", "camps", "on", "the", "mental", "health", "and", "psychosocial", "well-being", "of", "stateless", "populations", "such", "as", "the", "Rohingya,", "living", "in", "protracted", "humanitarian", "environment", "s." ]

[ 1, 1, 1, 1, 0, 1, 2, 0, 1, 2, 2, 0, 1, 0, 1, 0, 1, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 1, 2, 1, 2, 1, 1, 0, 0, 1, 1, 0, 0, 0, 1, 0, 0, 0, 1, 0, 1, 1, 2, 1, 2, 0, 1, 1, 0, 1, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 1, 2, 1, 1, 2, 0, 1, 2, 1, 0, 0, 1, 1, 0, 0, 1, 0, 1, 1, 2, 0, 1, 0, 0, 0, 1, 0, 1, 2, 1, 1, 2, 2, 1, 1, 1, 2, 0, 1, 2, 2, 1, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 1, 2, 1, 2, 0, 0, 0, 0, 0, 0, 1, 0, 1, 1, 2, 1, 2, 1, 0, 0, 1, 0, 1, 2, 2, 1, 2, 2, 2, 2, 0, 1, 0, 1, 1, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 2, 1, 1, 0, 1, 2, 1, 1, 1, 1, 1, 2, 0, 0, 0, 1, 1, 2, 0, 1, 2, 1, 1, 0, 0, 0, 1, 1, 0, 1, 0, 0, 1, 1, 0, 0, 0, 1, 0, 1, 2, 1, 0, 1, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 1, 2, 1, 2, 1, 0, 1, 2, 0, 0, 1, 2, 0, 1, 1, 0, 1, 2, 0, 0, 0, 1, 0, 0, 0, 1, 2, 0 ]

[ "Long-range", "allosteric", "regulation", "of", "the", "human", "26S", "proteasome", "by", "20S", "proteasome", "-", "targeting", "cancer", "drugs", "The", "proteasome", "holoenzyme", "is", "the", "major", "non-lysosomal", "protease;", "its", "proteolytic", "activity", "is", "essential", "for", "cellular", "homeostasis.", "Thus,", "it", "is", "an", "attractive", "target", "for", "the", "development", "of", "chemotherapeutics.", "While", "the", "structural", "basis", "of", "core", "particle", "(CP)", "inhibitors", "is", "largely", "understood,", "their", "structural", "impact", "on", "the", "proteasome", "holoenzyme", "remains", "entirely", "elusive.", "Here,", "we", "determined", "the", "structure", "of", "the", "26S", "proteasome", "with", "and", "without", "the", "inhibitor", "Oprozomib.", "Drug", "binding", "modifies", "the", "energy", "landscape", "of", "conformational", "motion", "in", "the", "proteasome", "regulatory", "particle", "(RP).", "Structurally,", "the", "energy", "barrier", "created", "by", "Oprozomib", "triggers", "a", "long-range", "allosteric", "regulation,", "resulting", "in", "the", "stabilization", "of", "a", "non-productive", "state.", "Thereby,", "the", "chemical", "drug-binding", "signal", "is", "converted,", "propagated", "and", "amplified", "into", "structural", "changes", "over", "a", "distance", "of", "more", "than", "150", "Å", "from", "the", "proteolytic", "site", "to", "the", "ubiquitin", "receptor", "Rpn10.", "The", "direct", "visualization", "of", "changes", "in", "conformational", "dynamics", "upon", "drug", "binding", "allows", "new", "ways", "to", "screen", "and", "develop", "future", "allosteric", "proteasome", "inhibitors." ]

[ 1, 1, 2, 0, 0, 1, 2, 2, 0, 1, 2, 0, 1, 1, 2, 0, 1, 1, 0, 0, 0, 1, 2, 0, 1, 2, 0, 1, 0, 1, 2, 0, 0, 0, 0, 1, 1, 0, 0, 1, 0, 1, 0, 0, 0, 1, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 1, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 1, 1, 2, 1, 0, 0, 1, 0, 1, 2, 0, 0, 1, 1, 2, 1, 0, 0, 1, 2, 0, 0, 1, 1, 0, 1, 1, 2, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 2, 1, 0, 1, 1, 0, 1, 0, 1, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 1, 0, 1, 2, 0, 1, 0, 1, 2, 0, 1, 2, 0, 0, 0, 0, 1, 0, 0, 0, 1, 1, 2 ]

[ "Statistical", "algorithms", "improve", "accuracy", "of", "gene", "fusion", "detection", "Gene", "fusions", "are", "known", "to", "play", "critical", "roles", "in", "tumor", "pathogenesis.", "Yet,", "sensitive", "and", "specific", "algorithms", "to", "detect", "gene", "fusions", "in", "cancer", "do", "not", "currently", "exist.", "In", "this", "paper,", "we", "present", "a", "new", "statistical", "algorithm,", "MACHETE", "(Mismatched", "Alignment", "CHimEra", "Tracking", "Engine),", "which", "achieves", "highly", "sensitive", "and", "specific", "detection", "of", "gene", "fusions", "from", "RNA-Seq", "data,", "including", "the", "highest", "Positive", "Predictive", "Value", "(PPV)", "compared", "to", "the", "current", "state-of-the-art,", "as", "assessed", "in", "simulated", "data.", "We", "show", "that", "the", "best", "performing", "published", "algorithms", "either", "find", "large", "numbers", "of", "fusions", "in", "negative", "control", "data", "or", "suffer", "from", "low", "sensitivity", "detecting", "known", "driving", "fusions", "in", "gold", "standard", "settings,", "such", "as", "EWSR1-FLI1.", "As", "proof", "of", "principle", "that", "MACHETE", "discovers", "novel", "gene", "fusions", "with", "high", "accuracy", "in", "vivo,", "we", "mined", "public", "data", "to", "discover", "and", "subsequently", "PCR", "validate", "novel", "gene", "fusions", "missed", "by", "other", "algorithms", "in", "the", "ovarian", "cancer", "cell", "line", "OVCAR3.", "These", "results", "highlight", "the", "gains", "in", "accuracy", "achieved", "by", "introducing", "statistical", "models", "into", "fusion", "detection,", "and", "pave", "the", "way", "for", "unbiased", "discovery", "of", "potentially", "driving", "and", "druggable", "gene", "fusions", "in", "primary", "tumors." ]

[ 1, 2, 1, 1, 0, 1, 2, 1, 1, 2, 0, 0, 0, 0, 0, 1, 0, 1, 1, 0, 1, 0, 1, 1, 0, 1, 1, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 1, 1, 2, 2, 2, 2, 0, 0, 0, 1, 0, 1, 1, 0, 1, 2, 0, 1, 2, 0, 0, 1, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 1, 2, 0, 1, 0, 1, 1, 2, 0, 0, 0, 1, 1, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 1, 1, 2, 0, 0, 1, 1, 2, 0, 0, 1, 1, 0, 1, 0, 0, 1, 1, 1, 1, 2, 1, 0, 0, 1, 0, 0, 1, 2, 1, 2, 1, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 1, 2, 0, 1, 1, 0, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 1, 2, 0, 1, 2 ]

[ "Palmoplantar", "pustulosis", "-", "a", "cross-sectional", "analysis", "in", "Germany", "Palmoplantar", "pustulosis", "(PPP)", "is", "a", "recalcitrant", "chronic", "inflammatory", "skin", "disease.", "Data", "relevant", "for", "the", "medical", "care", "of", "patients", "with", "PPP", "are", "scarce.", "Thus,", "the", "aim", "of", "this", "work", "was", "to", "investigate", "the", "disease", "burden,", "clinical", "characteristics,", "and", "comorbidity", "of", "PPP", "patients", "in", "Germany.", "PPP", "patients", "were", "examined", "in", "a", "crosssectional", "study", "at", "seven", "specialized", "psoriasis", "centers", "in", "Germany.", "Of", "the", "172", "included", "patients", "with", "PPP,", "79.1%", "were", "female", "and", "69.8%", "were", "smokers", ".In", "addition,", "25.0%", "suffered", "from", "psoriasis", "vulgaris,", "28.2%", "had", "documented", "psoriatic", "arthritis,", "and", "30.2%", "had", "a", "family", "history", "of", "psoriasis.", "In", "77", "patients", "the", "mean", "Dermatology", "Life", "Quality", "Index", "(DLQI)", "was", "12.2", "±", "7.7", "(mean", "±", "SD).", "The", "mean", "Psoriasis", "Palmoplantar", "Pustulosis", "Area", "and", "Severity", "Index", "(PPPASI)", "was", "12.6", "±", "8.6.", "Mean", "body", "mass", "index", "was", "above", "average", "at", "27.1", "±", "5.5.", "The", "PPP", "patients", "had", "previously", "received", "an", "average", "of", "2.6", "±", "2.1", "different", "anti-psoriatic", "systemic", "drugs", "or", "UV-therapies.", "The", "systemic", "drugs", "that", "had", "been", "used", "most", "frequently", "were", "corticosteroids", "in", "40.1%", "of", "patients,", "followed", "by", "acitretin", "(37.8%),", "and", "methotrexate", "(27.9%).", "The", "PPPASI", "was", "13.4", "±", "8.9", "in", "patients", "without", "current", "systemic", "therapy", "and", "10.4", "±", "7.9", "in", "patients", "with", "systemic", "therapy.", "Many", "PPP", "patients", "had", "a", "concomitant", "diagnosis", "of", "psoriasis", "vulgaris", "and/or", "psoriatic", "arthritis", "or", "had", "a", "family", "history", "of", "psoriasis.", "Despite", "the", "fact", "that", "many", "of", "the", "patients", "were", "using", "anti-psoriatic", "therapies,", "there", "was", "still", "a", "high", "burden", "of", "disease", "within", "this", "PPP", "cohort.", "This", "insufficient", "control", "of", "symptoms", "demonstrates", "the", "urgent", "need", "for", "new", "PPP", "treatments." ]

[ 1, 2, 0, 0, 1, 2, 0, 1, 1, 2, 1, 0, 0, 0, 1, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0, 1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 1, 2, 0, 1, 0, 1, 1, 0, 1, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 1, 0, 1, 0, 0, 1, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 0, 0, 1, 2, 2, 2, 1, 0, 0, 0, 0, 1, 0, 1, 0, 1, 1, 1, 2, 1, 0, 1, 2, 1, 0, 0, 0, 0, 1, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 1, 0, 0, 1, 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 1, 1, 0, 1, 2, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 1, 1, 0, 0, 1, 1, 0, 1, 2, 0, 1, 2, 0, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 0, 0, 1, 1, 2, 2, 0, 0, 0, 0, 0, 0, 1, 1 ]

[ "Platelet", "proteome", "reveals", "novel", "pathways", "of", "platelet", "activation", "and", "platelet", "-", "mediated", "immunoregulation", "in", "dengue", "Dengue", "is", "the", "most", "prevalent", "human", "arbovirus", "disease", "worldwide.", "Dengue", "virus", "(DENV)", "infection", "causes", "syndromes", "varying", "from", "self-limiting", "febrile", "illness", "to", "severe", "dengue.", "Although", "dengue", "pathophysiology", "is", "not", "completely", "understood,", "it", "is", "widely", "accepted", "that", "increased", "inflammation", "plays", "important", "roles", "in", "dengue", "pathogenesis.", "Platelets", "are", "blood", "cells", "classically", "known", "as", "effectors", "of", "hemostasis", "which", "have", "been", "increasingly", "recognized", "to", "have", "major", "immune", "and", "inflammatory", "activities.", "Nevertheless,", "the", "phenotype", "and", "effector", "functions", "of", "platelets", "in", "dengue", "pathogenesis", "are", "not", "completely", "understood.", "Here", "we", "used", "quantitative", "proteomics", "to", "investigate", "the", "protein", "content", "of", "platelets", "in", "clinical", "samples", "from", "patients", "with", "dengue", "compared", "to", "platelets", "from", "healthy", "donors.", "Our", "assays", "revealed", "a", "set", "of", "252", "differentially", "abundant", "proteins.", "In", "silico", "analyses", "associated", "these", "proteins", "with", "key", "molecular", "events", "including", "platelet", "activation", "and", "inflammatory", "responses,", "and", "with", "events", "not", "previously", "attributed", "to", "platelets", "during", "dengue", "infection", "including", "antigen", "processing", "and", "presentation,", "proteasome", "activity,", "and", "expression", "of", "histones.", "From", "these", "results,", "we", "conducted", "functional", "assays", "using", "samples", "from", "a", "larger", "cohort", "of", "patients", "and", "demonstrated", "evidence", "for", "platelet", "activation", "indicated", "by", "P-selectin", "(CD62P)", "translocation", "and", "secretion", "of", "granule-stored", "chemokines", "by", "platelets.", "In", "addition,", "we", "found", "evidence", "that", "DENV", "infection", "triggers", "HLA", "class", "I", "synthesis", "and", "surface", "expression", "by", "a", "mechanism", "depending", "on", "functional", "proteasome", "activity.", "Furthermore,", "we", "demonstrate", "that", "cell-free", "histone", "H2A", "released", "during", "dengue", "infection", "binds", "to", "platelets,", "increasing", "platelet", "activation.", "These", "findings", "are", "consistent", "with", "functional", "importance", "of", "HLA", "class", "I,", "proteasome", "subunits,", "and", "histones", "that", "we", "found", "exclusively", "in", "proteome", "analysis", "of", "platelets", "in", "samples", "from", "dengue", "patients.", "Our", "study", "provides", "the", "first", "in-depth", "characterization", "of", "the", "platelet", "proteome", "in", "dengue,", "and", "sheds", "light", "on", "new", "mechanisms", "of", "platelet", "activation", "and", "platelet", "-", "mediated", "immune", "and", "inflammatory", "responses." ]

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[ "Compensatory", "and", "decompensatory", "alterations", "in", "cardiomyocyte", "Ca(2+)", "dynamics", "in", "hearts", "with", "diastolic", "dysfunction", "following", "aortic", "banding", "At", "the", "cellular", "level", "cardiac", "hypertrophy", "causes", "remodelling,", "leading", "to", "changes", "in", "ionic", "channel,", "pump", "and", "exchanger", "densities", "and", "kinetics.", "Previous", "studies", "have", "focused", "on", "quantifying", "changes", "in", "channels,", "pump", "s", "and", "exchangers", "without", "quantitatively", "linking", "these", "changes", "with", "emergent", "cellular", "scale", "functionality.", "Two", "biophysical", "cardiac", "cell", "models", "were", "created,", "parameterized", "and", "validated", "and", "are", "able", "to", "simulate", "electrophysiology", "and", "calcium", "dynamics", "in", "myocytes", "from", "control", "sham", "operated", "rats", "and", "aortic", "-", "banded", "rats", "exhibiting", "diastolic", "dysfunction.", "The", "contribution", "of", "each", "ionic", "pathway", "to", "the", "calcium", "kinetics", "was", "calculated,", "identifying", "the", "L-type", "Ca(2+)", "channel", "and", "sarco/endoplasmic", "reticulum", "Ca(2+)", "ATPase", "as", "the", "principal", "regulators", "of", "systolic", "and", "diastolic", "Ca(2+),", "respectively.", "Results", "show", "that", "the", "ability", "to", "dynamically", "change", "systolic", "Ca(2+),", "through", "changes", "in", "expression", "of", "key", "Ca(2+)", "modelling", "protein", "densities,", "is", "drastically", "reduced", "following", "the", "aortic", "banding", "procedure;", "however", "the", "cells", "are", "able", "to", "compensate", "Ca(2+)", "homeostasis", "in", "an", "efficient", "way", "to", "minimize", "systolic", "dysfunction.", "Elevated", "left", "ventricular", "afterload", "leads", "to", "myocardial", "hypertrophy,", "diastolic", "dysfunction,", "cellular", "remodelling", "and", "compromised", "calcium", "dynamics.", "At", "the", "cellular", "scale", "this", "remodelling", "of", "the", "ionic", "channels,", "pumps", "and", "exchangers", "gives", "rise", "to", "changes", "in", "the", "Ca(2+)", "transient.", "However,", "the", "relative", "roles", "of", "the", "underlying", "subcellular", "processes", "and", "the", "positive", "or", "negative", "impact", "of", "each", "remodelling", "mechanism", "are", "not", "fully", "understood.", "Biophysical", "cardiac", "cell", "models", "were", "created", "to", "simulate", "electrophysiology", "and", "calcium", "dynamics", "in", "myocytes", "from", "control", "rats", "(SHAM)", "and", "aortic", "-", "banded", "rats", "exhibiting", "diastolic", "dysfunction.", "The", "model", "parameters", "and", "framework", "were", "validated", "and", "the", "fitted", "parameters", "demonstrated", "to", "be", "unique", "for", "explaining", "our", "experimental", "data.", "The", "contribution", "of", "each", "ionic", "pathway", "to", "the", "calcium", "kinetics", "was", "calculated,", "identifying", "the", "L-type", "Ca(2+)", "channel", "(LCC)", "and", "the", "sarco/endoplasmic", "reticulum", "Ca(2+)", "-ATPase", "(SERCA)", "as", "the", "principal", "regulators", "of", "systolic", "and", "diastolic", "Ca(2+),", "respectively.", "In", "the", "aortic", "banding", "model,", "the", "sensitivity", "of", "systolic", "Ca(2+)", "to", "LCC", "density", "and", "diastolic", "Ca(2+)", "to", "SERCA", "density", "decreased", "by", "16-fold", "and", "increased", "by", "23%,", "respectively,", "relative", "to", "the", "SHAM", "model.", "The", "energy", "cost", "of", "ionic", "homeostasis", "is", "maintained", "across", "the", "two", "models.", "The", "models", "predict", "that", "changes", "in", "ionic", "pathway", "densities", "in", "compensated", "aortic", "banding", "rats", "maintain", "Ca(2+)", "function", "and", "efficiency.", "The", "ability", "to", "dynamically", "alter", "systolic", "function", "is", "significantly", "diminished,", "while", "the", "capacity", "to", "maintain", "diastolic", "Ca(2+)", "is", "moderately", "increased." ]

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[ "Sensitivity", "and", "Specificity", "of", "Plasma", "ALT,", "ALP,", "and", "Bile", "Acids", "for", "Hepatitis", "in", "Labrador", "Retrievers", "Biochemical", "indicators", "for", "diagnosing", "liver", "disease", "are", "plasma", "alanine", "aminotransferase", "activity", "(ALT),", "alkaline", "phosphatase", "activity", "(ALP),", "and", "bile", "acid", "concentration", "(BA).", "To", "determine", "the", "sensitivity", "and", "specificity", "of", "ALT,", "ALP,", "and", "BA", "for", "detecting", "primary", "hepatitis", "(PH)", "in", "clinically", "healthy", "Labrador", "retrievers", "and", "investigate", "whether", "ALT", "and", "ALP", "can", "discriminate", "between", "dogs", "with", "PH", "and", "nonspecific", "reactive", "hepatitis", "(RH).", "191", "clinically", "healthy", "and", "51", "clinically", "ill", "Labrador", "retrievers", "with", "hepatic", "histopathology.", "Retrospective", "study.", "Medical", "records", "were", "reviewed", "for", "ALT,", "ALP,", "preprandial", "BA,", "liver", "histopathology,", "and", "hepatic", "copper", "concentrations.", "In", "64%", "(122/191)", "of", "the", "clinically", "healthy", "Labrador", "retrievers,", "hepatic", "histology", "revealed", "inflammatory", "infiltrates.", "This", "frequency", "might", "be", "biased", "because", "part", "of", "them", "was", "included", "as", "first-line", "relatives", "of", "dogs", "with", "copper-associated", "hepatitis.", "Sensitivity", "of", "ALT,", "ALP,", "and", "BA", "in", "this", "population", "for", "detecting", "acute", "hepatitis", "was", "45,", "15,", "and", "15%,", "respectively.", "For", "chronic", "hepatitis,", "sensitivity", "was", "71,", "35,", "and", "13%,", "respectively.", "Specificity", "of", "ALT,", "ALP,", "and", "BA", "was", ">90%", "for", "AH,", "CH,", "and", "RH.", "When", "increased", "liver", "enzymes", "were", "present,", "median", "ALT", "was", "significantly", "higher", "in", "PH", "cases", "(312", "U/L,", "range", "38-1,369)", "compared", "to", "RH", "cases", "(91", "U/L,", "range", "39-139)", "(P", "<", ".001).", "There", "was", "no", "difference", "in", "ALP", "between", "dogs", "with", "a", "PH", "and", "a", "RH", "(P", "=", ".361).", "Histopathologic", "abnormalities", "in", "the", "liver", "were", "present", "in", "the", "majority", "of", "apparent", "clinically", "healthy", "Labrador", "retrievers.", "The", "sensitivity", "of", "ALT,", "ALP,", "and", "BA", "for", "detecting", "acute", "and", "chronic", "hepatitis", "in", "this", "population", "was", "low.", "More", "sensitive", "biomarkers", "are", "needed", "for", "early", "detection", "of", "liver", "disease", "in", "apparent", "clinically", "healthy", "dogs." ]

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[ "A", "Conserved", "Role", "for", "VEGF", "Signaling", "in", "Specification", "of", "Homologous", "Mesenchymal", "Cell", "Types", "Positioned", "at", "Spatially", "Distinct", "Developmental", "Addresses", "in", "Early", "Development", "of", "Sea", "Urchins", "Comparative", "studies", "of", "early", "development", "in", "echinoderms", "are", "revealing", "the", "tempo", "and", "mode", "of", "alterations", "to", "developmental", "gene", "regulatory", "networks", "and", "to", "the", "cell", "types", "they", "specify.", "In", "euechinoid", "sea", "urchins,", "skeletogenic", "mesenchyme", "(SM)", "ingresses", "prior", "to", "gastrulation", "at", "the", "vegetal", "pole", "and", "aligns", "into", "a", "ring-like", "array", "with", "two", "bilateral", "pockets", "of", "cells,", "the", "sites", "where", "spiculogenesis", "will", "later", "occur.", "In", "cidaroid", "sea", "urchins,", "the", "anciently", "diverged", "sister", "clade", "to", "euechinoid", "sea", "urchins,", "a", "homologous", "SM", "cell", "type", "ingresses", "later", "in", "development,", "after", "gastrulation", "has", "commenced,", "and", "consequently", "at", "a", "distinct", "developmental", "address.", "Thus,", "a", "heterochronic", "shift", "of", "ingression", "of", "the", "SM", "cell", "type", "occurred", "in", "one", "of", "the", "echinoid", "lineages.", "In", "euechinoids,", "specification", "and", "migration", "of", "SM", "are", "facilitated", "by", "vascular", "endothelial", "growth", "factor", "(VEGF)", "signaling.", "We", "describe", "spatiotemporal", "expression", "of", "vegf", "and", "vegfr", "and", "experimental", "manipulations", "targeting", "VEGF", "signaling", "in", "the", "cidaroid", "Eucidaris", "tribuloides.", "Spatially,", "vegf", "and", "vegfr", "mRNA", "localizes", "similarly", "as", "in", "euechinoids,", "suggesting", "conserved", "deployment", "in", "echinoids", "despite", "their", "spatially", "distinct", "development", "addresses", "of", "ingression.", "Inhibition", "of", "VEGF", "signaling", "in", "E.", "tribuloides", "suggests", "its", "role", "in", "SM", "specification", "is", "conserved", "in", "echinoids.", "Temporal", "discrepancies", "between", "the", "onset", "of", "vegf", "expression", "and", "SM", "ingression", "likely", "result", "in", "previous", "observations", "of", "SM", "\"random", "wandering\"", "behavior.", "Our", "results", "indicate", "that,", "although", "the", "SM", "cell", "type", "in", "echinoids", "ingresses", "into", "distinct", "developmental", "landscapes,", "it", "retains", "a", "signaling", "mechanism", "that", "restricts", "their", "spatial", "localization", "to", "a", "conserved", "developmental", "address", "where", "spiculogenesis", "later", "occurs." ]

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[ "Epistatic", "influence", "in", "tomato", "Ve1", "-", "mediated", "resistance", "Resistance", "to", "Verticillium", "wilt", "disease", "is", "associated", "with", "the", "tomato", "Ve-locus;", "however,", "the", "individual", "functional", "roles", "of", "Ve1", "and", "Ve2", "in", "host", "plants", "remain", "controversial.", "As", "a", "first", "step", "towards", "Ve", "mutational", "analyses", "in", "planta,", "the", "Ve1", "coding", "region", "from", "a", "resistant", "tomato", "near-isoline", "(cv.", "Craigella", "GCR218)", "was", "introduced", "into", "a", "susceptible", "near-isoline", "(cv.", "Craigella", "GCR26).", "35S:Ve1", "plants", "segregated", "into", "two", "distinct", "classes;", "roughly", "half", "were", "resistant", "and", "half", "were", "susceptible.", "Ve1", "transcript", "levels", "were", "upregulated", "in", "both", "classes", "compared", "to", "wild-type", "plants,", "showing", "stable", "transgenic", "expression.", "Expression", "analysis", "of", "Ve2", "revealed", "that", "mRNA", "levels", "were", "similar", "between", "35S:Ve1", "and", "wild-type", "tomatoes,", "demonstrating", "that", "Ve1", "transgene", "introduction", "does", "not", "alter", "endogenous", "Ve2", "expression.", "Overall,", "the", "results", "of", "this", "study", "confirm", "the", "functional", "role", "of", "Ve1", "protein", "in", "resistance", "to", "the", "vascular", "fungal", "pathogen", "V.", "dahliae", "race", "1", "(Vd1),", "but", "suggest", "that", "a", "yet", "undefined", "factor", "exerts", "an", "epistatic", "influence", "on", "the", "Ve1", "gene.", "This", "article", "is", "protected", "by", "copyright.", "All", "rights", "reserved." ]

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[ "The", "impact", "of", "noninvasive", "follicular", "thyroid", "neoplasm", "with", "papillary-like", "nuclear", "features", "on", "the", "performance", "of", "the", "Afirma", "gene", "expression", "classifier", "A", "recent", "revision", "in", "thyroid", "tumor", "nomenclature", "has", "resulted", "in", "a", "change", "from", "a", "malignant", "diagnosis", "(noninvasive", "follicular", "variant", "of", "papillary", "thyroid", "carcinoma)", "to", "one", "that", "is", "nonmalignant", "(noninvasive", "follicular", "thyroid", "neoplasm", "with", "papillary-like", "nuclear", "features", "[NIFTP]).", "The", "objective", "of", "the", "current", "study", "was", "to", "evaluate", "the", "impact", "of", "this", "change", "on", "the", "performance", "of", "the", "Afirma", "gene", "expression", "classifier", "(GEC).", "The", "authors", "retrospectively", "analyzed", "consecutive", "thyroid", "fine-needle", "aspiration", "specimens", "with", "indeterminate", "diagnoses", "on", "which", "GEC", "was", "performed.", "Surgical", "pathology", "material", "was", "reviewed", "with", "the", "reclassification", "of", "nodules", "into", "NIFTP.", "GEC", "testing", "was", "performed", "on", "384", "fine-needle", "aspiration", "specimens", "diagnosed", "as", "atypia", "of", "undetermined", "significance", "(AUS)", "(304", "cases)", "and", "suspicious", "for", "a", "follicular", "neoplasm", "(SFN)", "(80", "cases)", "and", "yielded", "a", "suspicious", "result", "in", "152", "of", "the", "AUS", "cases", "(50%)", "and", "50", "of", "the", "SFN", "cases", "(63%).", "Thyroidectomy", "was", "performed", "on", "177", "patients.", "After", "reclassifying", "NIFTP,", "the", "positive", "predictive", "value", "of", "GEC", "decreased", "from", "42%", "(95%", "confidence", "interval", "[95%", "CI],", "39%-45%)", "to", "24%", "(95%", "CI,", "22%-26%)", "in", "the", "AUS", "group", "and", "from", "23%", "(95%", "CI,", "19%-27%)", "to", "13%", "(95%", "CI,", "9%-18%)", "in", "the", "SFN", "group.", "Total", "thyroidectomy", "was", "performed", "more", "frequently", "than", "a", "partial", "thyroidectomy", "in", "patients", "with", "AUS", "with", "a", "suspicious", "GEC", "result", "compared", "with", "pre-GEC", "controls", "(68%", "vs", "49%;", "P", "=", ".037).", "Reclassification", "of", "NIFTP", "significantly", "decreases", "the", "positive", "predictive", "value", "of", "GEC", "in", "indeterminate", "thyroid", "nodules.", "Nevertheless,", "the", "majority", "of", "patients", "with", "indeterminate", "thyroid", "nodules", "with", "a", "suspicious", "GEC", "result", "in", "the", "study", "institution", "have", "undergone", "total", "thyroidectomy.", "This", "finding", "raises", "concerns", "over", "reliance", "on", "a", "suspicious", "GEC", "result", "by", "clinicians", "to", "justify", "total", "thyroidectomy.", "Cancer", "Cytopathol", "2017.", "©", "2017", "American", "Cancer", "Society." ]

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[ "Behavioral", "Processes", "in", "Long-Lag", "Intervention", "Studies", "We", "argue", "that", "psychologists", "who", "conduct", "experiments", "with", "long", "lags", "between", "the", "manipulation", "and", "the", "outcome", "measure", "should", "pay", "more", "attention", "to", "behavioral", "processes", "that", "intervene", "between", "the", "manipulation", "and", "the", "outcome", "measure.", "Neglect", "of", "such", "processes,", "we", "contend,", "stems", "from", "psychology's", "long", "tradition", "of", "short-lag", "lab", "experiments", "where", "there", "is", "little", "scope", "for", "intervening", "behavioral", "processes.", "Studying", "process", "in", "the", "lab", "invariably", "involves", "studying", "psychological", "processes,", "but", "in", "long-lag", "field", "experiments", "it", "is", "important", "to", "study", "causally", "relevant", "behavioral", "processes", "as", "well", "as", "psychological", "ones.", "To", "illustrate", "the", "roles", "that", "behavioral", "processes", "can", "play", "in", "long-lag", "experiments", "we", "examine", "field", "experiments", "motivated", "by", "three", "policy", "-relevant", "goals:", "prejudice", "reduction,", "health", "promotion,", "and", "educational", "achievement.", "In", "each", "of", "the", "experiments", "discussed", "we", "identify", "various", "behavioral", "pathways", "through", "which", "the", "manipulated", "psychological", "state", "could", "have", "produced", "the", "observed", "outcome.", "We", "argue", "that", "if", "psychologists", "conducting", "long-lag", "interventions", "posited", "a", "theory", "of", "change", "that", "linked", "manipulated", "psychological", "states", "to", "outcomes", "via", "behavioral", "pathways,", "the", "result", "would", "be", "richer", "theory", "and", "more", "practically", "useful", "research.", "Movement", "in", "this", "direction", "would", "also", "permit", "more", "opportunities", "for", "productive", "collaborations", "between", "psychologists", "and", "other", "social", "scientists", "interested", "in", "similar", "social", "problems." ]

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[ "An", "example", "of", "host", "plant", "expansion", "of", "host", "-", "specialized", "Aphis", "gossypii", "Glover", "in", "the", "field", "The", "host", "plant", "expansion", "of", "host", "-", "specialized", "Aphis", "gossypii", "(Glover)", "has", "been", "well", "studied", "in", "the", "laboratory;", "however,", "this", "phenomenon", "is", "poorly", "understood", "in", "the", "field.", "Here,", "we", "provide", "a", "series", "of", "laboratory", "and", "field", "experiments", "to", "assess", "the", "role", "of", "zucchini", "in", "the", "host", "plant", "expansion", "of", "cotton", "-", "specialized", "aphids.", "We", "observed", "that", "cotton", "-", "specialized", "aphids", "possessed", "the", "ability", "to", "expand", "on", "a", "new", "host", "plant", "(cucumber),", "with", "individuals", "first", "recorded", "on", "June", "12", "and", "consequently", "increasing", "exponentially", "in", "number", "in", "a", "field", "cage.", "A", "bioassay", "experiment", "showed", "that", "aphids", "from", "both", "cotton", "and", "cucumber", "preferred", "their", "natal", "host,", "but", "clones", "from", "zucchini", "have", "a", "stronger", "preference", "for", "cucumber", "than", "cotton", "or", "zucchini.", "A", "total", "of", "1512", "individuals", "were", "collected", "from", "a", "cotton", "field", "(mixed", "cotton", "and", "cucurbit", "plot),", "cotton", "farmland", "(cotton", "alone)", "and", "a", "field", "cage", "and", "sequenced", "to", "identify", "their", "biotypes.", "The", "results", "for", "apterous", "individuals", "from", "the", "cotton", "field", "showed", "that", "more", "cucurbit", "-", "specialized", "biotypes", "occurred", "on", "cucumber", "and", "more", "cotton", "-", "specialized", "biotypes", "occurred", "on", "cotton", "and", "zucchini.", "A", "majority", "(>", "97.0%)", "of", "aphids", "from", "both", "the", "field", "cage", "and", "cotton", "farmland", "were", "cotton", "-", "specialized", "individuals.", "Consequently,", "eliminating", "intermediate", "host", "plants", "may", "be", "an", "effective", "measure", "to", "suppress", "A.", "gossypii", "outbreaks,", "because", "cotton", "and", "cucumber", "are", "often", "grown", "together", "in", "fields", "and", "greenhouses." ]

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[ "Molecular", "Imaging", "of", "Tumor", "Angiogenesis", "and", "Therapeutic", "Effects", "with", "Dual", "Bioluminescence", "Angiogenesis", "is", "critical", "for", "the", "growth", "of", "tumor", "by", "supplying", "nutrients", "and", "oxygen", "that", "exacerbates", "the", "metastasis", "and", "progression", "of", "cancer.", "Noninvasive", "imaging", "of", "angiogenesis", "during", "the", "tumor", "therapeutic", "processes", "may", "provide", "novel", "opportunities", "for", "image-guided", "tumor", "management.", "Here,", "we", "want", "to", "develop", "a", "mouse", "animal", "model", "for", "assessing", "cancer", "progression", "and", "angiogenesis", "in", "the", "same", "individuals", "by", "molecular", "imaging.", "Breast", "cancer", "model", "was", "developed", "with", "mouse", "breast", "cancer", "cell", "line", "4T1", "carrying", "a", "reporter", "system", "encoding", "a", "triple", "fusion", "(TF)", "reporter", "gene", "consisting", "of", "renilla", "luciferase", "(Rluc),", "red", "fluorescent", "protein", "(RFP)", "and", "herpes", "simplex", "virus", "truncated", "thymidine", "kinase", "(HSV-ttk)", "in", "transgenic", "mice,", "which", "expressed", "firefly", "luciferase", "(Fluc)", "under", "the", "promoter", "of", "vascular", "endothelial", "growth", "factor", "receptor", "2", "(Vegfr2-luc).", "The", "mice", "were", "subsequently", "treated", "with", "ganciclovir", "(GCV)", "and", "the", "tumor", "angiogenesis", "was", "tracked", "by", "Fluc", "imaging", "and", "the", "growth", "status", "of", "tumor", "was", "monitored", "by", "imaging", "of", "Rluc", "simultaneously.", "Overall,", "this", "traceable", "breast", "cancer", "model", "can", "simultaneously", "image", "the", "tumor", "growth", "and", "angiogenesis", "in", "single", "individual,", "which", "may", "facilitate", "a", "better", "understanding", "the", "mechanisms", "of", "angiogenesis", "in", "the", "progression", "and", "regression", "of", "tumor." ]

[ 1, 2, 0, 1, 2, 0, 1, 2, 0, 1, 2, 1, 0, 1, 0, 0, 1, 0, 1, 0, 1, 1, 0, 1, 0, 1, 0, 1, 0, 1, 0, 1, 1, 1, 0, 1, 0, 0, 1, 1, 2, 0, 0, 1, 1, 0, 1, 1, 1, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 1, 1, 1, 0, 1, 0, 0, 0, 1, 0, 1, 2, 1, 2, 2, 0, 0, 0, 1, 1, 2, 1, 2, 1, 0, 0, 1, 2, 1, 0, 1, 2, 2, 2, 2, 0, 0, 1, 2, 1, 1, 2, 2, 1, 0, 1, 2, 2, 1, 2, 2, 1, 0, 1, 2, 0, 0, 1, 2, 1, 0, 0, 1, 0, 1, 2, 2, 2, 2, 2, 1, 0, 1, 0, 0, 1, 0, 1, 1, 0, 0, 1, 2, 0, 0, 0, 1, 1, 0, 0, 1, 1, 0, 1, 0, 0, 0, 1, 0, 1, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 0, 1, 2, 0, 1, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 1, 0, 1, 0, 0, 1, 0, 1, 0, 1 ]

[ "The", "role", "of", "Indonesian", "patients'", "health", "behaviors", "in", "delaying", "the", "diagnosis", "of", "nasopharyngeal", "carcinoma", "With", "an", "estimated", "13,000", "newly", "diagnosed", "patients", "per", "year,", "nasopharyngeal", "carcinoma", "(NPC)", "is", "one", "of", "the", "most", "common", "types", "of", "cancer", "in", "males", "in", "Indonesia.", "Moreover,", "most", "patients", "are", "diagnosed", "at", "an", "advanced", "stage", "of", "the", "disease.", "This", "study", "aimed", "to", "explore", "the", "health", "behaviors", "of", "patients", "diagnosed", "with", "NPC", "and", "the", "possible", "causes", "of", "patient", "delay", "in", "NPC", "diagnosis.", "A", "qualitative", "research", "method", "was", "used", "to", "gain", "better", "insight", "into", "patient", "behaviors.", "Twelve", "patients", "were", "interviewed", "using", "semi-structured", "interview", "guidelines.", "All", "interviews", "were", "recorded,", "transcribed", "verbatim", "and", "analyzed", "according", "to", "a", "standard", "content", "analysis", "framework.", "Most", "patients", "had", "limited", "knowledge", "regarding", "NPC", "and", "its", "causes.", "Fifty", "percent", "of", "the", "patients", "had", "a", "delay", "of", "six", "months", "from", "the", "onset", "of", "symptoms", "to", "diagnosis.", "The", "main", "reason", "for", "this", "delay", "was", "the", "lack", "of", "awareness", "among", "the", "patients,", "which", "was", "influenced", "by", "their", "environment,", "economic", "status,", "family,", "culture,", "and", "religion.", "The", "perceived", "barriers", "to", "seeking", "medical", "help", "included", "direct", "non-", "medical", "costs", "not", "covered", "by", "health", "insurance,", "complex", "and", "time-consuming", "insurance", "and", "referral", "systems,", "and", "negative", "experiences", "in", "the", "past.", "Health", "insurance", "did", "motivate", "people", "to", "seek", "medical", "help.", "This", "study", "provides", "additional", "insight", "into", "patients", "'", "motivations", "to", "delay", "seeking", "medical", "help", "and", "can", "facilitate", "the", "design", "of", "NPC", "education", "programs.", "To", "improve", "awareness", "of", "the", "abovementioned", "causes", "for", "delay,", "community", "-based", "education", "programs", "are", "highly", "warranted", "and", "should", "focus", "on", "the", "recognition", "of", "NPC", "symptoms", "and", "possible", "solutions", "to", "overcome", "the", "main", "barriers", "at", "an", "earlier", "disease", "stage." ]

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[ "An", "environment", "-", "dependent", "transcriptional", "network", "specifies", "human", "microglia", "identity", "Microglia", "play", "essential", "roles", "in", "central", "nervous", "system", "(CNS)", "homeostasis", "and", "influence", "diverse", "aspects", "of", "neuronal", "function.", "However,", "the", "transcriptional", "mechanisms", "that", "specify", "human", "microglia", "phenotypes", "are", "largely", "unknown.", "We", "examined", "the", "transcriptomes", "and", "epigenetic", "landscapes", "of", "human", "microglia", "isolated", "from", "surgically", "resected", "brain", "tissue", "ex", "vivo", "and", "following", "transition", "to", "an", "in", "vitro", "environment.", "Transfer", "to", "a", "tissue", "culture", "environment", "results", "in", "rapid", "and", "extensive", "downregulation", "of", "microglia", "-specific", "genes", "that", "are", "induced", "in", "primitive", "mouse", "macrophages", "following", "migration", "into", "the", "fetal", "brain.", "Substantial", "subsets", "of", "these", "genes", "exhibit", "altered", "expression", "in", "neurodegenerative", "and", "behavioral", "diseases", "and", "are", "associated", "with", "non-coding", "risk", "variants.", "These", "findings", "reveal", "an", "environment", "-dependent", "transcriptional", "network", "specifying", "microglia", "-specific", "programs", "of", "gene", "expression", "and", "facilitate", "efforts", "to", "understand", "the", "roles", "of", "microglia", "in", "human", "disease." ]

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[ "Complete", "nucleotide", "sequence", "of", "a", "highly", "divergent", "cherry", "-associated", "luteovirus", "(ChALV)", "isolate", "from", "peach", "in", "South", "Korea", "We", "determined", "the", "complete", "genome", "sequence", "of", "a", "highly", "divergent", "South", "Korean", "(SK)", "isolate", "of", "a", "cherry", "-associated", "luteovirus", "(ChALV)", "from", "peach.", "The", "ChALV", "-", "SK", "genome", "consists", "of", "5,815", "nucleotides,", "and", "contains", "five", "open", "reading", "frames", "(ORFs).", "A", "comparative", "analysis", "of", "the", "full", "genome", "showed", "only", "73.1%", "nucleotide", "sequence", "identity", "with", "a", "recently", "described", "ChALV", "from", "the", "Czech", "Republic", "(CZ).", "Amino", "acid", "similarities", "of", "the", "individual", "ORFs", "between", "ChALV", "-", "SK", "and", "other", "luteoviruses", "range", "from", "17.3", "to", "92%,", "which", "places", "the", "new", "isolate", "close", "to", "the", "species", "demarcation", "value", "for", "luteoviruses.", "Results", "show", "our", "ChALV", "-", "SK", "isolate", "to", "be", "highly", "diverged", "from", "the", "ChALV", "-", "CZ", "isolate." ]

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[ "A", "Fluorescent", "Split", "Aptamer", "for", "Visualizing", "RNA-RNA", "Assembly", "In", "Vivo", "RNA-RNA", "assembly", "governs", "key", "biological", "processes", "and", "is", "a", "powerful", "tool", "for", "engineering", "synthetic", "genetic", "circuits.", "Characterizing", "RNA", "assembly", "in", "living", "cells", "often", "involves", "monitoring", "fluorescent", "reporter", "proteins,", "which", "are", "at", "best", "indirect", "measures", "of", "underlying", "RNA-RNA", "hybridization", "events", "and", "are", "subject", "to", "additional", "temporal", "and", "load", "constraints", "associated", "with", "translation", "and", "activation", "of", "reporter", "proteins.", "In", "contrast,", "RNA", "aptamers", "that", "sequester", "small", "molecule", "dyes", "and", "activate", "their", "fluorescence", "are", "increasingly", "utilized", "in", "genetically", "encoded", "strategies", "to", "report", "on", "RNA", "-", "level", "events.", "Split-aptamer", "systems", "have", "been", "rationally", "designed", "to", "generate", "signal", "upon", "hybridization", "of", "two", "or", "more", "discrete", "RNA", "transcripts,", "but", "none", "directly", "function", "when", "expressed", "in", "vivo.", "We", "reasoned", "that", "the", "improved", "physiological", "properties", "of", "the", "Broccoli", "aptamer", "enable", "construction", "of", "a", "split-aptamer", "system", "that", "could", "function", "in", "living", "cells.", "Here", "we", "present", "the", "Split-Broccoli", "system,", "in", "which", "self-assembly", "is", "nucleated", "by", "a", "thermostable,", "three-way", "junction", "RNA", "architecture", "and", "fluorescence", "activation", "requires", "both", "strands.", "Functional", "assembly", "of", "the", "system", "approximately", "follows", "second-order", "kinetics", "in", "vitro", "and", "improves", "when", "cotranscribed,", "rather", "than", "when", "assembled", "from", "purified", "components.", "Split-Broccoli", "fluorescence", "is", "digital", "in", "vivo", "and", "retains", "functional", "modularity", "when", "fused", "to", "RNAs", "that", "regulate", "circuit", "function", "through", "RNA-RNA", "hybridization,", "as", "demonstrated", "with", "an", "RNA", "Toehold", "switch.", "Split-Broccoli", "represents", "the", "first", "functional", "split-aptamer", "system", "to", "operate", "in", "vivo.", "It", "offers", "a", "genetically", "encoded", "and", "nondestructive", "platform", "to", "monitor", "and", "exploit", "RNA-RNA", "hybridization,", "whether", "as", "an", "all-", "RNA,", "stand-alone", "AND", "gate", "or", "as", "a", "tool", "for", "monitoring", "assembly", "of", "RNA-RNA", "hybrids." ]

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[ "The", "Diagnosis", "and", "Management", "of", "Chronic", "Migraine", "in", "Primary", "Care", "Chronic", "migraine", "is", "common,", "affecting", "approximately", "1%", "of", "the", "general", "population,", "and", "causes", "significant", "disability.", "To", "summarize", "optimal", "involvement", "of", "primary", "care", "physicians", "in", "chronic", "migraine", "care,", "and", "to", "provide", "algorithms", "to", "assist", "them", "in", "the", "diagnosis", "and", "management", "of", "patients", "with", "chronic", "migraine.", "An", "analysis", "of", "diagnostic", "and", "treatment", "needs", "in", "chronic", "migraine,", "based", "on", "a", "synthesis", "of", "the", "medical", "literature", "and", "clinical", "experience.", "Chronic", "migraine", "represents", "the", "more", "severe", "end", "of", "the", "migraine", "spectrum,", "usually", "arises", "out", "of", "previous", "episodic", "migraine,", "and", "is", "characterized", "by", "headache", "on", "15", "days", "a", "month", "or", "more.", "Importantly,", "the", "headache", "needs", "to", "meet", "migraine", "diagnostic", "criteria", "on", "only", "8", "days", "a", "month", "in", "order", "to", "meet", "chronic", "migraine", "diagnostic", "criteria.", "When", "acute", "medication", "overuse", "is", "present,", "a", "second", "diagnosis", "of", "medication", "overuse", "headache", "should", "be", "made.", "If", "patients", "meet", "criteria", "for", "chronic", "migraine,", "this", "excludes", "a", "diagnosis", "of", "chronic", "tension-type", "headache.", "Acute", "therapy", "of", "chronic", "migraine", "is", "similar", "to", "episodic", "migraine,", "except", "that", "medication", "overuse", "is", "a", "much", "greater", "risk", "in", "chronic", "migraine", "and", "must", "be", "addressed.", "All", "patients", "should", "be", "considered", "for", "pharmacological", "prophylaxis,", "and", "the", "behavioral", "aspects", "of", "therapy", "should", "be", "emphasized.", "The", "two", "prophylactic", "drugs", "with", "the", "best", "evidence", "for", "efficacy", "in", "chronic", "migraine", "are", "topiramate", "and", "onabotulinumtoxinA.", "Given", "the", "disability", "caused", "by", "chronic", "migraine,", "these", "should", "both", "be", "available", "to", "patients", "as", "necessary.", "Management", "of", "chronic", "migraine", "is", "complex,", "and", "many", "patients", "are", "relatively", "refractory", "to", "therapy.", "Specialist", "referral", "will", "often", "be", "required", "and", "should", "not", "be", "unduly", "delayed.", "On", "the", "other", "hand,", "the", "primary", "care", "physician", "should", "be", "able", "to", "make", "the", "diagnosis,", "initiate", "therapy,", "and", "manage", "some", "less", "refractory", "patients", "without", "referral.", "The", "timing", "of", "referral", "should", "depend", "both", "on", "the", "expertise", "of", "the", "primary", "care", "physician", "in", "headache", "management", "and", "the", "patient's", "response", "to", "initial", "therapy." ]

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[ "Dietary", "grape", "seed", "proanthocyanidins", "inactivate", "regulatory", "T", "cells", "by", "promoting", "NER", "-", "dependent", "DNA", "repair", "in", "dendritic", "cells", "in", "UVB", "-", "exposed", "skin", "Ultraviolet", "B", "(UVB)", "radiation", "induces", "regulatory", "T", "cells", "(Treg", "cells)", "and", "depletion", "of", "these", "Treg", "cells", "alleviates", "immunosuppression", "and", "inhibits", "photocarcinogenesis", "in", "mice.", "Here,", "we", "determined", "the", "effects", "of", "dietary", "grape", "seed", "proanthocyanidins", "(GSPs)", "on", "the", "development", "and", "activity", "of", "UVB", "-", "induced", "Treg", "cells.", "C3H/HeN", "mice", "fed", "a", "GSPs", "(0.5%,", "w/w)-", "supplemented", "or", "control", "diet", "were", "exposed", "to", "UVB", "(150", "mJ/cm2)", "radiation,", "sensitized", "to", "2,4-dinitrofluorobenzene", "(DNFB)", "and", "sacrificed", "5", "days", "later.", "FACS", "analysis", "indicated", "that", "dietary", "GSPs", "decrease", "the", "numbers", "of", "UVB", "-", "induced", "Treg", "cells.", "ELISA", "analysis", "of", "cultured", "sorted", "Treg", "cells", "indicated", "that", "secretion", "of", "immunosuppressive", "cytokines", "(interleukin-10,", "TGF-β)", "was", "significantly", "lower", "in", "Treg", "cells", "from", "GSPs", "-", "fed", "mice.", "Dietary", "GSPs", "also", "enhanced", "the", "ability", "of", "Treg", "cells", "from", "wild-type", "mice", "to", "stimulate", "production", "of", "IFNγ", "by", "T", "cells.", "These", "effects", "of", "dietary", "GSPs", "on", "Treg", "cell", "function", "were", "not", "found", "in", "XPA", "-", "deficient", "mice,", "which", "are", "incapable", "of", "repairing", "UVB", "-", "induced", "DNA", "damage.", "Adoptive", "transfer", "experiments", "revealed", "that", "naïve", "recipients", "that", "received", "Treg", "cells", "from", "GSPs", "-", "fed", "UVB", "-", "irradiated", "wild-type", "donors", "that", "had", "been", "sensitized", "to", "DNFB", "exhibited", "a", "significantly", "higher", "contact", "hypersensitivity", "(CHS)", "response", "to", "DNFB", "than", "mice", "that", "received", "Treg", "cells", "from", "UVB", "-", "exposed", "mice", "fed", "the", "control", "diet.", "There", "was", "no", "significant", "difference", "in", "the", "CHS", "response", "between", "mice", "that", "received", "Treg", "cells", "from", "UVB", "-", "irradiated", "XPA", "-", "deficient", "donors", "fed", "GSPs", "or", "the", "control", "diet.", "Furthermore,", "dietary", "GSPs", "significantly", "inhibited", "UVB", "-", "induced", "skin", "tumor", "development", "in", "wild-type", "mice", "but", "not", "in", "XPA", "-", "deficient", "mice.", "These", "results", "suggest", "that", "GSPs", "inactivate", "Treg", "cells", "by", "promoting", "DNA", "repair", "in", "dendritic", "cells", "in", "UVB", "-", "exposed", "skin." ]

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[ "Rinsing", "paired-agent", "model", "(RPAM)", "to", "quantify", "cell-surface", "receptor", "concentrations", "in", "topical", "staining", "applications", "of", "thick", "tissues", "Conventional", "molecular", "assessment", "of", "tissue", "through", "histology,", "if", "adapted", "to", "fresh", "thicker", "samples,", "has", "the", "potential", "to", "enhance", "cancer", "detection", "in", "surgical", "margins", "and", "monitoring", "of", "3D", "cell", "culture", "molecular", "environments.", "However,", "in", "thicker", "samples,", "substantial", "background", "staining", "is", "common", "despite", "repeated", "rinsing,", "which", "can", "significantly", "reduce", "image", "contrast.", "Recently,", "'", "paired-agent'", "methods", "-which", "employ", "co-administration", "of", "a", "control", "(untargeted)", "imaging", "agent", "-have", "been", "applied", "to", "thick", "-", "sample", "staining", "applications", "to", "account", "for", "background", "staining.", "To", "date,", "these", "methods", "have", "included", "(1)", "a", "simple", "ratiometric", "method", "that", "is", "relatively", "insensitive", "to", "noise", "in", "the", "data", "but", "has", "accuracy", "that", "is", "dependent", "on", "the", "staining", "protocol", "and", "the", "characteristics", "of", "the", "sample;", "and", "(2)", "a", "complex", "paired-agent", "kinetic", "modeling", "method", "that", "is", "more", "accurate", "but", "is", "more", "noise-sensitive", "and", "requires", "a", "precise", "serial", "rinsing", "protocol.", "Here,", "a", "new", "simplified", "mathematical", "model-the", "rinsing", "paired-agent", "model", "(RPAM)-is", "derived", "and", "tested", "that", "offers", "a", "good", "balance", "between", "the", "previous", "models,", "is", "adaptable", "to", "arbitrary", "rinsing-imaging", "protocols,", "and", "does", "not", "require", "calibration", "of", "the", "imaging", "system.", "RPAM", "is", "evaluated", "against", "previous", "models", "and", "is", "validated", "by", "comparison", "to", "estimated", "concentrations", "of", "targeted", "biomarkers", "on", "the", "surface", "of", "3D", "cell", "culture", "and", "tumor", "xenograft", "models.", "This", "work", "supports", "the", "use", "of", "RPAM", "as", "a", "preferable", "model", "to", "quantitatively", "analyze", "targeted", "biomarker", "concentrations", "in", "topically", "stained", "thick", "tissues,", "as", "it", "was", "found", "to", "match", "the", "accuracy", "of", "the", "complex", "paired-agent", "kinetic", "model", "while", "retaining", "the", "low", "noise-sensitivity", "characteristics", "of", "the", "ratiometric", "method." ]

[ 1, 2, 2, 1, 0, 1, 1, 2, 1, 0, 1, 1, 0, 0, 1, 1, 1, 1, 2, 0, 1, 1, 1, 0, 0, 0, 1, 2, 2, 0, 0, 1, 0, 1, 1, 2, 0, 1, 2, 0, 1, 0, 1, 2, 2, 0, 0, 0, 0, 1, 2, 0, 1, 2, 0, 1, 0, 1, 1, 0, 0, 1, 1, 1, 1, 0, 0, 1, 2, 0, 1, 0, 0, 0, 1, 2, 2, 2, 0, 0, 1, 0, 1, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 1, 0, 0, 1, 0, 0, 1, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 1, 1, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 1, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 1, 1, 0, 0, 0, 1, 1, 2, 0, 0, 0, 0, 1, 0, 0, 1, 2, 1, 0, 0, 0, 1, 1, 0, 0, 0, 0, 1, 0, 1, 1, 0, 1, 1, 0, 0, 1, 0, 1, 2, 2, 0, 1, 1, 2, 0, 0, 0, 0, 1, 2, 1, 0, 0, 0, 1, 0, 1, 2, 1, 1, 1, 0, 1, 1, 1, 1, 0, 0, 0, 0, 0, 1, 0, 1, 0, 0, 0, 1, 2, 2, 0, 1, 0, 1, 1, 1, 0, 0, 1, 2 ]

[ "Beneficial", "Effects", "of", "Two", "Types", "of", "Personal", "Health", "Record", "Services", "Connected", "With", "Electronic", "Medical", "Records", "Within", "the", "Hospital", "Setting", "Healthcare", "consumers", "must", "be", "able", "to", "make", "decisions", "based", "on", "accurate", "health", "information.", "To", "assist", "with", "this,", "we", "designed", "and", "developed", "an", "integrated", "system", "connected", "with", "electronic", "medical", "records", "in", "hospitals", "to", "ensure", "delivery", "of", "accurate", "health", "information.", "The", "system", "-called", "the", "Consumer-centered", "Open", "Personal", "Health", "Record", "platform", "-is", "composed", "of", "two", "services:", "a", "portal", "for", "users", "with", "any", "disease", "and", "a", "mobile", "application", "for", "users", "with", "cleft", "lip", "/", "palate.", "To", "assess", "the", "benefits", "of", "these", "services,", "we", "used", "a", "quasi-experimental,", "pretest-posttest", "design,", "assigning", "participants", "to", "the", "portal", "(n", "=", "50)", "and", "application", "(n", "=", "52)", "groups.", "Both", "groups", "showed", "significantly", "increased", "knowledge,", "both", "objective", "(actual", "knowledge", "of", "health", "information)", "and", "subjective", "(C", "of", "health", "information),", "after", "the", "intervention.", "Furthermore,", "while", "both", "groups", "showed", "higher", "information", "needs", "satisfaction", "after", "the", "intervention,", "the", "application", "group", "was", "significantly", "more", "satisfied.", "Knowledge", "changes", "were", "more", "affected", "by", "participant", "characteristics", "in", "the", "application", "group.", "Our", "results", "may", "be", "due", "to", "the", "application's", "provision", "of", "specific", "disease", "information", "and", "a", "personalized", "treatment", "plan", "based", "on", "the", "participant", "and", "other", "users'", "data.", "We", "recommend", "that", "services", "connected", "with", "electronic", "medical", "records", "target", "specific", "diseases", "to", "provide", "personalized", "health", "management", "to", "patients", "in", "a", "hospital", "setting." ]

[ 1, 2, 0, 0, 1, 0, 1, 2, 2, 1, 0, 0, 1, 2, 2, 0, 0, 1, 2, 1, 2, 0, 0, 0, 0, 0, 1, 0, 0, 1, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 1, 0, 0, 1, 0, 1, 1, 2, 0, 1, 0, 0, 1, 2, 2, 2, 2, 2, 0, 0, 0, 0, 1, 0, 1, 2, 2, 0, 0, 1, 0, 0, 1, 2, 0, 1, 0, 1, 2, 0, 1, 0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 1, 2, 2, 0, 1, 0, 0, 1, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 1, 2, 0, 0, 1, 1, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 1, 0, 0, 0, 1, 0, 0, 1, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 0, 0, 1, 0, 0, 0, 1, 0, 1, 1, 0, 0, 1, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 1, 1, 1, 0, 0, 1, 1, 2, 0, 0, 0, 1, 0, 0, 1, 2, 0, 0, 0, 1, 0, 0, 1, 2, 2, 0, 1, 1, 0, 0, 1, 1, 2, 0, 1, 0, 0, 1, 2 ]

[ "RhoA", "/", "Rock", "Inhibition", "Improves", "the", "Beneficial", "Effects", "of", "Glucocorticoid", "Treatment", "in", "Dystrophic", "Muscle:", "Implications", "for", "Stem", "Cell", "Depletion", "Glucocorticoid", "treatment", "represents", "a", "standard", "palliative", "treatment", "for", "Duchenne", "muscular", "dystrophy", "(DMD)", "patients,", "but", "various", "adverse", "effects", "have", "limited", "this", "treatment.", "In", "an", "effort", "to", "understand", "the", "mechanism(s)", "by", "which", "glucocorticoids", "impart", "their", "effects", "on", "the", "dystrophic", "muscle,", "and", "potentially", "reduce", "the", "adverse", "effects,", "we", "have", "studied", "the", "effect", "of", "prednisolone", "treatment", "in", "dystrophin", "/", "utrophin", "double", "knockout", "(dKO)", "mice,", "which", "exhibit", "a", "severe", "dystrophic", "phenotype", "due", "to", "rapid", "muscle", "stem", "cell", "depletion.", "Our", "results", "indicate", "that", "muscle", "stem", "cell", "depletion", "in", "dKO", "muscle", "is", "related", "to", "upregulation", "of", "mTOR,", "and", "that", "prednisolone", "treatment", "reduces", "the", "expression", "of", "mTOR", "and", "other", "pro-inflammatory", "mediators,", "consequently", "slowing", "down", "muscle", "stem", "cell", "depletion.", "However,", "prednisolone", "treatment", "was", "unable", "to", "improve", "the", "myogenesis", "of", "stem", "cells", "and", "reduce", "fibrosis", "in", "dKO", "muscle.", "We", "then", "studied", "whether", "glucocorticoid", "treatment", "can", "be", "improved", "by", "co-administration", "of", "an", "inhibitor", "of", "RhoA", "/", "ROCK", "signaling,", "which", "can", "be", "activated", "by", "glucocorticoids", "and", "was", "found", "in", "our", "previous", "work", "to", "be", "over-activated", "in", "dystrophic", "muscle.", "Our", "results", "indicate", "that", "the", "combination", "of", "RhoA", "/", "ROCK", "inhibition", "and", "glucocorticoid", "treatment", "in", "dystrophic", "muscle", "have", "a", "synergistic", "effect", "in", "alleviating", "the", "dystrophic", "phenotype.", "Taken", "together,", "our", "study", "not", "only", "shed", "light", "on", "the", "mechanism", "by", "which", "glucocorticoid", "imparts", "its", "beneficial", "effect", "on", "dystrophic", "muscle,", "but", "also", "revealed", "the", "synergistic", "effect", "of", "RhoA", "/", "ROCK", "inhibition", "and", "glucocorticoid", "treatment,", "which", "could", "lead", "to", "the", "development", "of", "more", "efficient", "therapeutic", "approaches", "for", "treating", "DMD", "patients." ]

[ 1, 0, 1, 1, 0, 0, 1, 1, 0, 1, 2, 0, 1, 2, 0, 0, 1, 2, 1, 1, 2, 0, 0, 0, 1, 2, 0, 1, 2, 2, 1, 1, 0, 0, 1, 2, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 0, 1, 0, 0, 1, 2, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0, 1, 1, 0, 1, 0, 1, 1, 2, 2, 2, 0, 0, 0, 0, 1, 1, 0, 0, 0, 1, 2, 2, 1, 0, 0, 0, 0, 1, 2, 2, 1, 0, 1, 1, 0, 0, 0, 1, 0, 1, 0, 0, 1, 1, 0, 0, 1, 0, 1, 0, 0, 1, 2, 0, 1, 2, 1, 2, 2, 1, 0, 1, 1, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 1, 0, 1, 1, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 1, 0, 0, 1, 0, 1, 0, 1, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 1, 0, 1, 1, 0, 1, 2, 0, 1, 2, 0, 0, 1, 1, 0, 0, 0, 1, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 1, 0, 0, 1, 1, 0, 1, 2, 0, 0, 0, 0, 1, 1, 0, 1, 0, 1, 1, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 1, 1, 1 ]

[ "Eye", "abduction", "reduces", "but", "does", "not", "eliminate", "competition", "in", "the", "oculomotor", "system", "Although", "it", "is", "well", "established", "that", "there", "is", "a", "tight", "coupling", "between", "covert", "attention", "and", "the", "eye", "movement", "system", "there", "is", "an", "ongoing", "controversy", "whether", "this", "relationship", "is", "functional.", "Previous", "studies", "demonstrated", "that", "disrupting", "the", "ability", "to", "execute", "an", "eye", "movement", "interferes", "with", "the", "allocation", "of", "covert", "attention.", "One", "technique", "that", "prevents", "the", "execution", "of", "an", "eye", "movement", "involves", "the", "abduction", "of", "the", "eye", "in", "the", "orbit", "while", "presenting", "the", "stimuli", "outside", "of", "the", "effective", "oculomotor", "range", "(Craighero,", "Nascimben,", "&", "Fadiga,", "2004).", "Although", "eye", "abduction", "is", "supposed", "to", "disrupt", "activation", "of", "the", "oculomotor", "program", "responsible", "for", "the", "shift", "of", "covert", "attention,", "this", "crucial", "assumption", "has", "never", "been", "tested", "experimentally.", "In", "the", "present", "study", "we", "used", "saccadic", "curvature", "to", "examine", "whether", "eye", "abduction", "eliminates", "the", "target-distractor", "competition", "in", "the", "oculomotor", "system.", "We", "experimentally", "reduced", "the", "ability", "to", "execute", "saccades", "by", "abducting", "the", "eye", "by", "30°", "(monocular", "vision).", "This", "way", "the", "peripheral", "part", "of", "the", "temporal", "hemifield", "was", "located", "outside", "the", "oculomotor", "range.", "Participants", "made", "a", "vertical", "eye", "movement", "while", "on", "some", "trials", "a", "distractor", "was", "shown", "either", "inside", "or", "outside", "of", "the", "oculomotor", "range.", "The", "curvature", "away", "from", "distractors", "located", "outside", "the", "oculomotor", "range", "was", "reduced,", "but", "not", "completely", "eliminated.", "This", "confirms", "that", "eye", "abduction", "influences", "the", "activation", "of", "the", "oculomotor", "program,", "but", "points", "to", "the", "fact", "that", "other", "forms", "of", "motor", "planning,", "such", "as", "head", "movements", "are", "also", "represented", "in", "the", "oculomotor", "system.", "The", "results", "are", "in", "line", "with", "the", "idea", "that", "covert", "attention", "is", "an", "emerging", "property", "of", "movement", "planning,", "but", "is", "not", "restricted", "to", "saccade", "planning." ]

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[ "Inversion", "3", "Cytogenetic", "Abnormality", "in", "an", "Allogeneic", "Hematopoietic", "Cell", "Transplant", "Recipient", "Representative", "of", "a", "Donor", "Derived", "Constitutional", "Abnormality", "Allogeneic", "hematopoietic", "cell", "transplantation", "(HCT)", "is", "an", "important", "treatment", "for", "many", "severe", "hematological", "disorders.", "However", "HCT", "can", "be", "associated", "with", "significant", "complications", "including", "organ", "toxicity,", "graft", "-versus-host", "disease", "and", "relapse.", "One", "other", "serious", "but", "rare", "complication", "is", "the", "transmission", "of", "hematologic", "and", "non-", "hematologic", "diseases", "from", "the", "donor", "to", "the", "recipient.", "With", "older", "donors,", "the", "risk", "of", "an", "abnormality", "in", "the", "donor", "may", "be", "higher.", "Here", "we", "describe", "the", "transmission", "of", "an", "inversion", "3", "constitutional", "cytogenetic", "abnormality", "from", "an", "unrelated", "donor", "to", "a", "recipient", "and", "review", "the", "clinical", "implications", "of", "the", "discovery", "of", "donor", "-", "derived", "constitutional", "cytogenetic", "abnormalities." ]

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[ "An", "amperometric", "H2O2", "biosensor", "based", "on", "hemoglobin", "nanoparticles", "immobilized", "onto", "a", "gold", "electrode", "The", "nanoparticles", "(NPs)", "of", "hemoglobin", "(Hb)", "were", "prepared", "by", "desolvation", "method", "and", "characterized", "by", "transmission", "electron", "microscopy", "(TEM),", "ultraviolet", "(UV)", "spectroscopy", "and", "Fourier-transform", "infrared", "spectroscopy", "(FTIR).", "An", "amperometric", "H2O2", "biosensor", "was", "constructed", "by", "immobilizing", "Hb", "NPs", "covalently", "onto", "a", "polycrystalline", "Au", "electrode", "(Au", "E).", "Hb", "NPs", "/", "Au", "E", "was", "characterized", "by", "scanning", "electron", "microscopy", "(SEM),", "cyclic", "voltammetry", "(CV)", "and", "electrochemical", "impedance", "spectra", "(EIS)", "before", "and", "after", "immobilization", "of", "Hb", "NPs.", "The", "Hb", "NPs", "/", "Au", "electrode", "showed", "optimum", "response", "within", "2.5s", "at", "pH", "6.5", "in", "0.1M", "sodium", "phosphate", "buffer", "containing", "100μM", "H2O2", "and", "30⁰C,", "when", "operated", "at", "-0.2V", "against", "Ag/AgCl.", "The", "H", "bN", "Ps/", "A", "uE", "exhibited", "Vmax", "of", "5.161±0.1", "μA", "cm(-2)", "with", "Michaelis-Menten", "constant", "(Km)", "of", "0.1±0.01mM.", "The", "biosensor", "showed", "lower", "detection", "limit", "(1.0μM),", "high", "sensitivity", "(129±0.25μA", "cm(-2)", "mM(-1))", "and", "wider", "linear", "range", "(1.0-1200μM)", "for", "H2O2", "as", "compared", "to", "earlier", "biosensors.", "The", "analytical", "recoveries", "of", "added", "H2O2", "in", "serum", "(0.5μM", "and1.0μM)", "were", "97.77%", "and", "98.01%", "respectively", "and", "within", "and", "between", "batch", "coefficients", "of", "variation", "(CV)", "were", "3.16%", "and", "3.36%", "respectively.", "There", "was", "a", "good", "correlation", "between", "sera", "H2O2", "values", "obtained", "by", "standard", "enzymic", "colourimetric", "method", "and", "the", "present", "biosensor", "(R(2)=0.99).", "The", "biosensor", "measured", "H2O2", "level", "in", "sera", "of", "apparently", "healthy", "subjects", "and", "persons", "suffering", "from", "diabetes", "type", "II.", "The", "Hb", "NPs", "/", "Au", "electrode", "lost", "10%", "of", "its", "initial", "activity", "after", "90", "days", "of", "its", "regular", "uses,", "when", "stored", "dry", "at", "4(o)C." ]

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