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Please translate the following sentences from Chinese to English.
基于力矩的发动机建模和速度跟踪控制
Torque-based Engine Modeling and Feedback Linearization Tracking Control of Engine Speed
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Torque-based Engine Modeling and Feedback Linearization Tracking Control of Engine Speed
基于力矩的发动机建模和速度跟踪控制
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珠江三角洲新生儿转运网络10年工作及效果报告
The 10-year Work and Effect of the Neonate Transport Network(NTN) in Pearl River (Zhujiang) delta
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The 10-year Work and Effect of the Neonate Transport Network(NTN) in Pearl River (Zhujiang) delta
珠江三角洲新生儿转运网络10年工作及效果报告
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基于三阶段DEA模型的区域生态效率研究
Research on Ecological Efficiency Based on Three-Stage DEA Model
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Research on Ecological Efficiency Based on Three-Stage DEA Model
基于三阶段DEA模型的区域生态效率研究
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疫苗接种对北京市托幼园所和中小学校水痘流行特征的影响。目的 了解疫苗接种对北京市托幼园所、中小学校水痘流行特征的影响.方法 通过国家疾病监测信息报告管理系统追踪北京市托幼园所、中小学校2008-2010年发病的临床诊断水痘病例,开展流行病学个案调查,分析分布特征.结果 共调查水痘病例21 474例,其中:55.3%(11 883例)的病例接种过水痘疫苗;有明确免疫史的病例中,接种时间距离发病时间在30 d~1年的占3.4%(286/8510)、1~3年的占18.2%(1551/8510)、3~5年的占28.6%(2431/8510)、5~10年的占34.3%(2916/8510)(时间区间均为左闭右开);无免疫史的病例发病年龄高峰为4岁,有免疫史的病例发病年龄高峰为6岁;有免疫史(≥30 d)病例的比率由2008年的42.4%(2862/6754)上升到2010年的56.3%(4327/7679);未发热病例有免疫史(≥30 d)的比率(54.9%,6413/11 679)高于发热病例(47.7%,4533/9500)(P <0.01);轻症病例中有免疫史(≥30 d)的比率(57.4%,8045/14 020)高于中重度病例(40.2%,2902/7216)(P<0.01).结论 疫苗接种推迟了水痘发病高峰,减轻了疾病症状,但既有免疫策略无法阻断水痘在托幼园所、中小学校内的传播.
The epidemiological impact of varicella vaccination in kindergartens, primary and secondary schools in Bering. Objective To study the epidemiological impact of varicella vaccine vaccination on kindergartens and school children in Beijing.Methods According to " China Information System for Diseases Control and Prevention",the reported clinical diagnosis varicella cases were tracked in kindergartens,primary and secondary schools whose onset date were from 2008 to 2010.Epidemiological survey was conducted and epidemiological features were analyzed.Results A total of 21 474 varicella cases were investigated: 55.3% (11 883 cases) had been vaccinated by varicella vaccine.Of cases with definite immunization history,interval between vaccination date and onset date were from 30 days to 1 year accounted for 3.4% (286/8510),1 to 3 years accounted for 18.2% (1551/8510),3 to 5 years accounted for 28.6%(2431/8510),5 to 10 years accounted for 34.3% (2916/8510) ( left-closed right-open interval) ; The peak age of onset was 4 years old in cases without immunization history,which was 6 years old in cases with immunization history; The proportion of cases with immunization history ( ≥ 30 days) had increased from 42.4% (2862/6754) in 2008 to 56.3% (4327/7679) in 2010.The cases with no fever had a higher proportion (54.9%,6413/11 679 ) of immunization history ( ≥ 30 days) than cases with fever (47.7%,4533/9500) (P< 0.01 ); The cases with rashes less than 50 had a higher proportion (57.4%,8045/14 020) of immunization history ( ≥ 30 days) than cases with rashes more than 50 (40.2%,2902/7216) (P < 0.01 ).Conclusion Varicella vaccine delays the peak age of onset,alleviates the symptoms.The current immunization strategy can not block varicella spread in kindergartens,primary and secondary schools.
Please translate the following sentences from English to Chinese.
The epidemiological impact of varicella vaccination in kindergartens, primary and secondary schools in Bering. Objective To study the epidemiological impact of varicella vaccine vaccination on kindergartens and school children in Beijing.Methods According to " China Information System for Diseases Control and Prevention",the reported clinical diagnosis varicella cases were tracked in kindergartens,primary and secondary schools whose onset date were from 2008 to 2010.Epidemiological survey was conducted and epidemiological features were analyzed.Results A total of 21 474 varicella cases were investigated: 55.3% (11 883 cases) had been vaccinated by varicella vaccine.Of cases with definite immunization history,interval between vaccination date and onset date were from 30 days to 1 year accounted for 3.4% (286/8510),1 to 3 years accounted for 18.2% (1551/8510),3 to 5 years accounted for 28.6%(2431/8510),5 to 10 years accounted for 34.3% (2916/8510) ( left-closed right-open interval) ; The peak age of onset was 4 years old in cases without immunization history,which was 6 years old in cases with immunization history; The proportion of cases with immunization history ( ≥ 30 days) had increased from 42.4% (2862/6754) in 2008 to 56.3% (4327/7679) in 2010.The cases with no fever had a higher proportion (54.9%,6413/11 679 ) of immunization history ( ≥ 30 days) than cases with fever (47.7%,4533/9500) (P< 0.01 ); The cases with rashes less than 50 had a higher proportion (57.4%,8045/14 020) of immunization history ( ≥ 30 days) than cases with rashes more than 50 (40.2%,2902/7216) (P < 0.01 ).Conclusion Varicella vaccine delays the peak age of onset,alleviates the symptoms.The current immunization strategy can not block varicella spread in kindergartens,primary and secondary schools.
疫苗接种对北京市托幼园所和中小学校水痘流行特征的影响。目的 了解疫苗接种对北京市托幼园所、中小学校水痘流行特征的影响.方法 通过国家疾病监测信息报告管理系统追踪北京市托幼园所、中小学校2008-2010年发病的临床诊断水痘病例,开展流行病学个案调查,分析分布特征.结果 共调查水痘病例21 474例,其中:55.3%(11 883例)的病例接种过水痘疫苗;有明确免疫史的病例中,接种时间距离发病时间在30 d~1年的占3.4%(286/8510)、1~3年的占18.2%(1551/8510)、3~5年的占28.6%(2431/8510)、5~10年的占34.3%(2916/8510)(时间区间均为左闭右开);无免疫史的病例发病年龄高峰为4岁,有免疫史的病例发病年龄高峰为6岁;有免疫史(≥30 d)病例的比率由2008年的42.4%(2862/6754)上升到2010年的56.3%(4327/7679);未发热病例有免疫史(≥30 d)的比率(54.9%,6413/11 679)高于发热病例(47.7%,4533/9500)(P <0.01);轻症病例中有免疫史(≥30 d)的比率(57.4%,8045/14 020)高于中重度病例(40.2%,2902/7216)(P<0.01).结论 疫苗接种推迟了水痘发病高峰,减轻了疾病症状,但既有免疫策略无法阻断水痘在托幼园所、中小学校内的传播.
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在线教育弹幕情感信息智能识别模型研究——融合变式情感词典与深度学习技术
A Sentimental Information Intelligent Recognition Model Research for Online Education Barrage——Fusing Variant Sentiment Dictionary and Deep Learning Technology
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A Sentimental Information Intelligent Recognition Model Research for Online Education Barrage——Fusing Variant Sentiment Dictionary and Deep Learning Technology
在线教育弹幕情感信息智能识别模型研究——融合变式情感词典与深度学习技术
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关于"民族"定义
On the Definitions of "Minzu"
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On the Definitions of "Minzu"
关于"民族"定义
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家电行业应收账款管理研究——以海尔集团为例
Research on Accounts Receivable Management of Household Appliance Industry——Taking Haier Group as an example
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Research on Accounts Receivable Management of Household Appliance Industry——Taking Haier Group as an example
家电行业应收账款管理研究——以海尔集团为例
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地区主义与跨界民族主义——论中国西南边疆跨界民族主义
Regionalism and Cross- Border Ethnicalism——On the Cross - Border Ethnicalism in the Border Region of Southwest China
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Regionalism and Cross- Border Ethnicalism——On the Cross - Border Ethnicalism in the Border Region of Southwest China
地区主义与跨界民族主义——论中国西南边疆跨界民族主义
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介语短语作形容词补足语及语义关系
On Prepositional Phrass as Adjective Complementation and Their Semantic Relations
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On Prepositional Phrass as Adjective Complementation and Their Semantic Relations
介语短语作形容词补足语及语义关系
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胃癌根治术后腹腔淋巴瘘的发生原因及处理
Causes and treatment of lymphatic fistulas after the radical operation of gastric cancer
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Causes and treatment of lymphatic fistulas after the radical operation of gastric cancer
胃癌根治术后腹腔淋巴瘘的发生原因及处理
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生产性服务业集聚度的现状研判及其对策研究——以安徽省为例
Analysis on status and countermeasure of agglomeration level of productive service industry: taking Anhui Province as an example
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Analysis on status and countermeasure of agglomeration level of productive service industry: taking Anhui Province as an example
生产性服务业集聚度的现状研判及其对策研究——以安徽省为例
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GPS高程转换中考虑地形改正的几何方法
A geometric method for GPS height transformation with topographic corrections
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A geometric method for GPS height transformation with topographic corrections
GPS高程转换中考虑地形改正的几何方法
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现代建筑的隐喻主义建筑观
Metaphor doctrine building view of modern architecture
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Metaphor doctrine building view of modern architecture
现代建筑的隐喻主义建筑观
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小型遥感航拍直升机造型设计
Small Sensing Aerial Helicopter Design
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Small Sensing Aerial Helicopter Design
小型遥感航拍直升机造型设计
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鼻敏2号合剂治疗变应性鼻炎临床疗效和对血清IgE影响的观察
Clinical observation on NO.2 mixture in treating allergic rhinitis and its effects on IgE
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Clinical observation on NO.2 mixture in treating allergic rhinitis and its effects on IgE
鼻敏2号合剂治疗变应性鼻炎临床疗效和对血清IgE影响的观察
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电子束物理气相沉积叶片热障涂层工艺稳定性提升技术研究
Investigation on Improvement of Process Stability of Thermal Barrier Coatings on Blades Prepared by Electron Beam Physical Vapour Deposition
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Investigation on Improvement of Process Stability of Thermal Barrier Coatings on Blades Prepared by Electron Beam Physical Vapour Deposition
电子束物理气相沉积叶片热障涂层工艺稳定性提升技术研究
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CCGA焊接故障分析及可靠性研究
Study on Soldering Failure Analysis and Assembly Reliability of CCGA
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Study on Soldering Failure Analysis and Assembly Reliability of CCGA
CCGA焊接故障分析及可靠性研究
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江华苦茶种质资源的亲缘关系及在茶树进化中的地位研究进展
Relationship of Thea assamica CV.Jianghua Germplasm Resources and Its Status in the Process of Tea Evolution
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Relationship of Thea assamica CV.Jianghua Germplasm Resources and Its Status in the Process of Tea Evolution
江华苦茶种质资源的亲缘关系及在茶树进化中的地位研究进展
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阿托伐他汀对鼠动脉粥样硬化基质金属蛋白酶和蛋白激酶C的影响
The Effect of Atovastatin on Protein Kinase C and Matrix Metalloproteinases in Rat Model of Atherosclerosis
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The Effect of Atovastatin on Protein Kinase C and Matrix Metalloproteinases in Rat Model of Atherosclerosis
阿托伐他汀对鼠动脉粥样硬化基质金属蛋白酶和蛋白激酶C的影响
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农村基层治理的现实困境与改进路径。自20世纪90年代末以来,以村民自治为核心的农村基层民主模式已在全国实行30多年。但随着农村经济社会的快速变革,农村基层治理环境也发生了深刻改变,给以村民自治为主的乡村治理带来了新的挑战和问题,包括现有自治单元难以发挥作用、农村家庭矛盾增多、乡村环境问题日趋严重等。为此,要进一步提升乡村治理能力,推进农村基层民主建设,鼓励基层自治单元创新,增强农村组织治理能力;整合乡土社会现有资本,重构乡村传统价值体系;改革公共产品供给体制,构建多元协作供给模式。
Rural Grassroots Governance:Realistic Predicament and Improved Path. Since the late 1990s,Villagers' autonomy as the core of rural grassroots democratic model has beenpracticed in the country for more than 30 years. At present,with the rapid reform of rural economic and social, the rural grass-roots governance environment has had the profound change,which has brought new challenges and problems,including the difficulty of the existing autonomous units, the increase of rural family conflicts, and the increasingly serious environmental problems in rural areas. Therefore,improving the capacity of rural governance and promote the grassroots level construction,need to encourage grass-roots autonomous units of innovation,reconstruction of rural traditional value system,Construction of public product diversity collaboration supply mode.
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Rural Grassroots Governance:Realistic Predicament and Improved Path. Since the late 1990s,Villagers' autonomy as the core of rural grassroots democratic model has beenpracticed in the country for more than 30 years. At present,with the rapid reform of rural economic and social, the rural grass-roots governance environment has had the profound change,which has brought new challenges and problems,including the difficulty of the existing autonomous units, the increase of rural family conflicts, and the increasingly serious environmental problems in rural areas. Therefore,improving the capacity of rural governance and promote the grassroots level construction,need to encourage grass-roots autonomous units of innovation,reconstruction of rural traditional value system,Construction of public product diversity collaboration supply mode.
农村基层治理的现实困境与改进路径。自20世纪90年代末以来,以村民自治为核心的农村基层民主模式已在全国实行30多年。但随着农村经济社会的快速变革,农村基层治理环境也发生了深刻改变,给以村民自治为主的乡村治理带来了新的挑战和问题,包括现有自治单元难以发挥作用、农村家庭矛盾增多、乡村环境问题日趋严重等。为此,要进一步提升乡村治理能力,推进农村基层民主建设,鼓励基层自治单元创新,增强农村组织治理能力;整合乡土社会现有资本,重构乡村传统价值体系;改革公共产品供给体制,构建多元协作供给模式。
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教学诊断与改进视域下高职院校"中国服装史"课程实践研究
Practical Research on the"History of Chinese Clothing"Course in Higher Vocational Colleges from the Perspective of Teaching Diagnosis and Improvement
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Practical Research on the"History of Chinese Clothing"Course in Higher Vocational Colleges from the Perspective of Teaching Diagnosis and Improvement
教学诊断与改进视域下高职院校"中国服装史"课程实践研究
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基于聚吡咯微电极的MEMS微型超级电容器的研究
Fabrication and Tests of a Micro-Supercapacitor Using Polypyrrole-Based Micro-Electrode
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Fabrication and Tests of a Micro-Supercapacitor Using Polypyrrole-Based Micro-Electrode
基于聚吡咯微电极的MEMS微型超级电容器的研究
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抓节能减排工作促行业技术进步——访中国热处理行业协会秘书长佟晓辉
Promoting industry technology progress by energy saving & emission reduction——Interview with Tong Xiaohui, secretary general of China Heat Treatment Association
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Promoting industry technology progress by energy saving & emission reduction——Interview with Tong Xiaohui, secretary general of China Heat Treatment Association
抓节能减排工作促行业技术进步——访中国热处理行业协会秘书长佟晓辉
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电动汽车空调驱动系统的仿真研究
Simulation Research on the Air-conditioning Drive System of Electric Vehicles
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Simulation Research on the Air-conditioning Drive System of Electric Vehicles
电动汽车空调驱动系统的仿真研究
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明代蒙学“考德”之探微
The Study of primary school "Moral Investigation" in the Ming Dynasty
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The Study of primary school "Moral Investigation" in the Ming Dynasty
明代蒙学“考德”之探微
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农田害虫色彩特征提取的研究
Study on Extracting Agricultural Pests' Color Features
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Study on Extracting Agricultural Pests' Color Features
农田害虫色彩特征提取的研究
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乳腺摄影中对比度细节评价方法的探讨
Investigation of evaluation method for contrast detail in mammography
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Investigation of evaluation method for contrast detail in mammography
乳腺摄影中对比度细节评价方法的探讨
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氧化再生纤维素膜在大鼠贲门周围血管离断术中的应用
The application of oxidized regenerated cellulose mesh in the rat model of pericardial devascularization
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The application of oxidized regenerated cellulose mesh in the rat model of pericardial devascularization
氧化再生纤维素膜在大鼠贲门周围血管离断术中的应用
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油田采出水结垢影响因素分析
Influence Factors Analysis of Scale Formation of Oilfield Produced Water
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Influence Factors Analysis of Scale Formation of Oilfield Produced Water
油田采出水结垢影响因素分析
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聚己内酯-碳酸亚乙酯[Poly(CL-EC)]和血管内皮生长因子(VEGF)静电混纺支架的构建及其生物学性能
The preparation of electrospun scaffolds by ethylenecarbonate-ε-caprolactone [Poly(CL-EC)] copolymer blended with vascular endothelial growth factor (VEGF) and study of its biological performance
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The preparation of electrospun scaffolds by ethylenecarbonate-ε-caprolactone [Poly(CL-EC)] copolymer blended with vascular endothelial growth factor (VEGF) and study of its biological performance
聚己内酯-碳酸亚乙酯[Poly(CL-EC)]和血管内皮生长因子(VEGF)静电混纺支架的构建及其生物学性能
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论加入WTO与政府依法行政
Accession to the WTO & Government Administration
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Accession to the WTO & Government Administration
论加入WTO与政府依法行政
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蝎毒多肽提取物对前列腺癌细胞增殖的影响
Polypeptide Extract from Scorpion Venom(PESV) Inhibits Proliferation on Prostate Cancer Androgen-Independent Cell Lines in Vitro
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Polypeptide Extract from Scorpion Venom(PESV) Inhibits Proliferation on Prostate Cancer Androgen-Independent Cell Lines in Vitro
蝎毒多肽提取物对前列腺癌细胞增殖的影响
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亟待保护的齐长城
URGENT! PROTECT THE QI GREAT WALL
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URGENT! PROTECT THE QI GREAT WALL
亟待保护的齐长城
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自然主义泛心论:基本观念和问题
Naturalistic Panpsychism: Fundamental Ideas and Problems
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Naturalistic Panpsychism: Fundamental Ideas and Problems
自然主义泛心论:基本观念和问题
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高功率单管半导体激光器光纤耦合技术。高功率半导体激光技术的快速发展使得单元器件性能实现了重大突破,但在光束质量上仍存在较大的缺陷,难以同时得到较高的输出功率和亮度。探索将激光器快慢轴分别准直后直接耦合进入光纤,既可以避免使用到复杂光学系统又可以获得较高的输出功率。实验选取四只工作电流为2A,输出功率分别为1.636W、1.662W、1.659W、1.643W的980nm的单管半导体激光器作为光源,通过空间合束技术耦合进芯径200μm、数值孔径0.22的光纤中,输出功率3.41W,光纤耦合效率为51.7%。
Fiber Coupling Technology of High Power Semiconductor Laser. The rapid development of high power semiconductor laser technology has achieved a major breakthrough in performance unit device. But the shortcomings of the beam quality lead to be difficulty to obtain high output power. The fast and slow axes of collimating lasers are directly coupled into the fiber. It can not only avoid the use of com-plex optical systems but also obtain higher output power. Four laser diodes beam at 980nm, were coupled into a core diameter of 200μm, numerical aperture (NA) 0.22 fiber via spatial combination. The fiber coupling output power is 3.41W at current 2A,and the system efficiency is 51.7%.
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Fiber Coupling Technology of High Power Semiconductor Laser. The rapid development of high power semiconductor laser technology has achieved a major breakthrough in performance unit device. But the shortcomings of the beam quality lead to be difficulty to obtain high output power. The fast and slow axes of collimating lasers are directly coupled into the fiber. It can not only avoid the use of com-plex optical systems but also obtain higher output power. Four laser diodes beam at 980nm, were coupled into a core diameter of 200μm, numerical aperture (NA) 0.22 fiber via spatial combination. The fiber coupling output power is 3.41W at current 2A,and the system efficiency is 51.7%.
高功率单管半导体激光器光纤耦合技术。高功率半导体激光技术的快速发展使得单元器件性能实现了重大突破,但在光束质量上仍存在较大的缺陷,难以同时得到较高的输出功率和亮度。探索将激光器快慢轴分别准直后直接耦合进入光纤,既可以避免使用到复杂光学系统又可以获得较高的输出功率。实验选取四只工作电流为2A,输出功率分别为1.636W、1.662W、1.659W、1.643W的980nm的单管半导体激光器作为光源,通过空间合束技术耦合进芯径200μm、数值孔径0.22的光纤中,输出功率3.41W,光纤耦合效率为51.7%。
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新型漏斗车减速器研制
Development of the New Type Hopper Car Decelerator
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Development of the New Type Hopper Car Decelerator
新型漏斗车减速器研制
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手术切除联合射频消融治疗多发性肝癌合并肝硬化
Surgical resection combined with radiofrequency ablation for multifocal hepatocellular carcinomas in patients with cirrhosis
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Surgical resection combined with radiofrequency ablation for multifocal hepatocellular carcinomas in patients with cirrhosis
手术切除联合射频消融治疗多发性肝癌合并肝硬化
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成人原位肝移植术后早期他克莫司个体化给药研究
Personalized medicine of Tacrolimus in early postoperative phase in adult orthotopic liver transplantation
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Personalized medicine of Tacrolimus in early postoperative phase in adult orthotopic liver transplantation
成人原位肝移植术后早期他克莫司个体化给药研究
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党的先进性是实现社会主义现代化的根本保证
The superority of CPC is the basic guarantee to realize the socialist modernization of China
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The superority of CPC is the basic guarantee to realize the socialist modernization of China
党的先进性是实现社会主义现代化的根本保证
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库普弗细胞在酒精性肝病发病机制中的作用研究进展
Research development of the role of Kupffer cell in the pathogenesis of alcoholic liver disease
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Research development of the role of Kupffer cell in the pathogenesis of alcoholic liver disease
库普弗细胞在酒精性肝病发病机制中的作用研究进展
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牛膝多糖对糖尿病大鼠视网膜细胞凋亡的影响
Effect of achyranthes bidentata blume polysaccharides on apoptosis in retina of diabetic rats
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Effect of achyranthes bidentata blume polysaccharides on apoptosis in retina of diabetic rats
牛膝多糖对糖尿病大鼠视网膜细胞凋亡的影响
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大鼠电击死后心肌骨骼肌脑的病理学观察
Experimental study on cardiac muscle skeletal muscle brain after electrocution
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Experimental study on cardiac muscle skeletal muscle brain after electrocution
大鼠电击死后心肌骨骼肌脑的病理学观察
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DNA甲基化改变与糖尿病肾病发病的相关性研究进展。糖尿病肾病(diabetic nephropathy,DN)是糖尿病的主要并发症之一,也是终末期肾功能衰竭的主要原因。代谢记忆,即之前存在的高血糖增加了发生DN的风险,造成了长期的代谢紊乱。已有研究显示,表观遗传学与代谢记忆存在一定的相关性。表观遗传学是指在不改变核苷酸序列的前提下,引起基因表达模式的可遗传性变化,包括DNA甲基化、组蛋白的共价修饰和非编码RNAs。最近发现一些基因,AFF3、RGMA-MCTP2、SP3-CDCA7及其变异体与糖尿病肾病的相关性,已经达到全基因组性显著,更加说明表观遗传对糖尿病肾病发生发展的影响。本综述主要讨论糖尿病肾病患者的体液(包括唾液、尿液及外周血液)以及肾组织中DNA甲基化改变的发现和进展,进一步了解表观遗传在人类DN中的机制作用,并为DN表观遗传学的新兴课题提供新观点。
Study on the relationship between DNA methylation changes and the pathogenesis of diabetic nephropathy. Diabetic nephropathy(DN) is one of the main complications of diabetes and the main cause of end-stage renal failure.Metabolic memory of pre-existing hyperglycemia increases the risk of DN and causes long-term metabolic disorders.Studies have shown that there is a certain correlation between epigenetics and metabolic memory.Epigenetics refers to the heritable changes in gene expression patterns without changing the nucleotide sequence, and includes DNA methylation, covalent modification of histones, and non-coding RNAs.Recently, it has been discovered that some genes, includingAFF3, RGMA-MCTP2, SP3-CDCA7 and their variants, have reached a genome-wide significant correlation with DN, which further illustrates the influence of epigenetics on the occurrence and development of DN.This review mainly discusses the discovery and progress of changes in DNA methylation in the body fluids (including saliva, urine and peripheral blood) and kidney tissues of patients with DN, and provides new perspectives for further understanding the role of epigenetics in the mechanism undelying human DN, and for emerging topic of DN epigenetics.
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Study on the relationship between DNA methylation changes and the pathogenesis of diabetic nephropathy. Diabetic nephropathy(DN) is one of the main complications of diabetes and the main cause of end-stage renal failure.Metabolic memory of pre-existing hyperglycemia increases the risk of DN and causes long-term metabolic disorders.Studies have shown that there is a certain correlation between epigenetics and metabolic memory.Epigenetics refers to the heritable changes in gene expression patterns without changing the nucleotide sequence, and includes DNA methylation, covalent modification of histones, and non-coding RNAs.Recently, it has been discovered that some genes, includingAFF3, RGMA-MCTP2, SP3-CDCA7 and their variants, have reached a genome-wide significant correlation with DN, which further illustrates the influence of epigenetics on the occurrence and development of DN.This review mainly discusses the discovery and progress of changes in DNA methylation in the body fluids (including saliva, urine and peripheral blood) and kidney tissues of patients with DN, and provides new perspectives for further understanding the role of epigenetics in the mechanism undelying human DN, and for emerging topic of DN epigenetics.
DNA甲基化改变与糖尿病肾病发病的相关性研究进展。糖尿病肾病(diabetic nephropathy,DN)是糖尿病的主要并发症之一,也是终末期肾功能衰竭的主要原因。代谢记忆,即之前存在的高血糖增加了发生DN的风险,造成了长期的代谢紊乱。已有研究显示,表观遗传学与代谢记忆存在一定的相关性。表观遗传学是指在不改变核苷酸序列的前提下,引起基因表达模式的可遗传性变化,包括DNA甲基化、组蛋白的共价修饰和非编码RNAs。最近发现一些基因,AFF3、RGMA-MCTP2、SP3-CDCA7及其变异体与糖尿病肾病的相关性,已经达到全基因组性显著,更加说明表观遗传对糖尿病肾病发生发展的影响。本综述主要讨论糖尿病肾病患者的体液(包括唾液、尿液及外周血液)以及肾组织中DNA甲基化改变的发现和进展,进一步了解表观遗传在人类DN中的机制作用,并为DN表观遗传学的新兴课题提供新观点。
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鄂尔多斯盆地都思兔河流域白垩系含水层特征及供水前景分析
Characteristics of Cretaceous aquifer and water supply prospect of Dusitu River Valley in Ordos Basin
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Characteristics of Cretaceous aquifer and water supply prospect of Dusitu River Valley in Ordos Basin
鄂尔多斯盆地都思兔河流域白垩系含水层特征及供水前景分析
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颈前路人工椎间盘置换术与颈前路椎间减压融合术后吞咽困难并发症的比较分析
A comparison of anterior artificial disc insertion and anterior cervical discectomy and fusion in postoperative dysphagia
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A comparison of anterior artificial disc insertion and anterior cervical discectomy and fusion in postoperative dysphagia
颈前路人工椎间盘置换术与颈前路椎间减压融合术后吞咽困难并发症的比较分析
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朴拙的诗意——阿来短篇小说论
Unadorned Poeticality:on A Lai's Short Stories
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Unadorned Poeticality:on A Lai's Short Stories
朴拙的诗意——阿来短篇小说论
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不同吸氧浓度和时间在新生小鼠视网膜病发病中的作用
Role of different oxygen concentration and different period of oxygen exposure in pathogenesis of retinopathy in neonatal mice
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Role of different oxygen concentration and different period of oxygen exposure in pathogenesis of retinopathy in neonatal mice
不同吸氧浓度和时间在新生小鼠视网膜病发病中的作用
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大山包黑颈鹤国家级自然保护区的植物生态生活型研究
Eco-life Form of Plants from Dashanbao Black-necked Crane National Nature Reserve
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Eco-life Form of Plants from Dashanbao Black-necked Crane National Nature Reserve
大山包黑颈鹤国家级自然保护区的植物生态生活型研究
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智能天线中自适应波束形成算法的DSP实现
The DSP Realization of Adaptive beam Forming Algorithm in Smart Antenna
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The DSP Realization of Adaptive beam Forming Algorithm in Smart Antenna
智能天线中自适应波束形成算法的DSP实现
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技术跨越的另一种解读:复杂性理论的视角
A new analysis of technological leapfrogging:a perspective of complexity theory
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A new analysis of technological leapfrogging:a perspective of complexity theory
技术跨越的另一种解读:复杂性理论的视角