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10,907,942 | Delayed adjuvant tamoxifen: ten-year results of a collaborative randomized controlled trial in early breast cancer (TAM-02 trial). | Annals of oncology : official journal of the European Society for Medical Oncology | Ann Oncol | 11 | 5 | 10.1023/a:1008321415065 | eng | 2,000 | 5 | null | null | null | null | [AIM] Immediate adjuvant tamoxifen reduces disease recurrence and improves survival in patients with early breast cancer. However, is it too late to administer tamoxifen to patients who have already undergone treatment, but were unable to benefit from this adjuvant therapy? The French National Cancer Centers (FNCLCC) h... | null | 1.005 | 311 | Hematology; Medicine; Oncology | Medicine | 2,000 |
10,907,571 | Thrombolysis in the air. Air-ambulance paramedics flying to remote communities treat patients before hospitalization. | Canadian family physician Medecin de famille canadien | Can Fam Physician | 46 | null | null | eng | 2,000 | 6 | null | null | null | null | [PROBLEM ADDRESSED] First Nations* communities in the North have a high prevalence of coronary artery disease and type 2 diabetes and face an increasing incidence of myocardial infarction (MI). Many conditions delay timely administration of thrombolysis, including long times between when patients first experience sympt... | null | null | null | null | null | null |
10,907,382 | Validation of death certificate diagnosis of out-of-hospital coronary heart disease deaths in Olmsted County, Minnesota. | Mayo Clinic proceedings | Mayo Clin Proc | 75 | 7 | 10.4065/75.7.681 | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] To evaluate the validity of death certificate diagnosis of out-of-hospital (OOH) coronary heart disease (CHD) and sudden cardiac death (SCD) in Olmsted County, Minnesota, between 1981 and 1994. [METHODS] In this review of the medical records, autopsy reports, and coroner's files, OOH deaths with heart disea... | null | 0.837 | 221 | Medicine | Medicine | 2,000 |
10,906,831 | The fetal and childhood growth of persons who develop type 2 diabetes. | Annals of internal medicine | Ann Intern Med | 133 | 3 | 10.7326/0003-4819-133-3-200008010-00008 | eng | 2,000 | 8 | 1 | null | null | null | [BACKGROUND] Type 2 diabetes is associated with low birthweight followed by obesity in adulthood. Persons who develop the disease may therefore have a particular pattern of growth from birth through childhood. [OBJECTIVE] To examine the relation of type 2 diabetes to size at birth and childhood growth. [DESIGN] Cohort ... | null | 4.465 | 445 | Internal Medicine; Medicine | Medicine | 2,000 |
10,906,024 | Bone metabolism and mineral density following renal transplantation. | Archives of disease in childhood | Arch Dis Child | 83 | 2 | 10.1136/adc.83.2.146 | eng | 2,000 | 8 | null | null | null | null | [AIM] To study bone turnover following renal transplantation using a panel of biochemical markers and to correlate the results with both areal and volumetric bone mineral density (BMD). [PATIENTS] A total of 31 patients aged 18.1 years were transplanted 5.4 years before this study. Control patients (n = 31) were age an... | null | 0.891 | 169 | Pediatrics, Perinatology and Child Health | Medicine | 2,000 |
10,906,023 | Intravenous pamidronate in juvenile osteoporosis. | Archives of disease in childhood | Arch Dis Child | 83 | 2 | 10.1136/adc.83.2.143 | eng | 2,000 | 8 | null | null | null | null | [AIMS] To investigate the use of the aminobisphosphonate, disodium pamidronate, in children with vertebral osteoporosis. [METHODS] Five children (aged 10-15 years) with vertebral osteoporosis who developed compression fractures in the thoracic and/or lumbar spine as a consequence of five different conditions, received ... | null | 0.891 | 169 | Pediatrics, Perinatology and Child Health | Medicine | 2,000 |
10,905,388 | Comparison between four immunoassays for growth hormone (GH) measurement as guides to clinical decisions following GH provocative tests. | Journal of pediatric endocrinology & metabolism : JPEM | J Pediatr Endocrinol Metab | 13 | 6 | 10.1515/jpem.2000.13.6.637 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVE] To compare four assays for the measurement of GH following provocative tests and to assess the projected clinical decisions, which would have been based on their respective results. [DESIGN] Multiple assays of serum samples obtained during provocative tests for GH response. [SUBJECTS] Forty-seven children w... | null | null | null | null | null | null |
10,905,385 | Risk factors for microalbuminuria in children and adolescents with type 1 diabetes. | Journal of pediatric endocrinology & metabolism : JPEM | J Pediatr Endocrinol Metab | 13 | 6 | 10.1515/jpem.2000.13.6.613 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVES] The aim of this study was to investigate the influence of sex, age, diabetes duration, puberty, blood pressure, glycemic control and parental blood pressure on microalbuminuria in children with type 1 diabetes. [STUDY DESIGN] The study was a multicenter cross-sectional survey including 702 children and ado... | null | null | null | null | null | null |
10,905,077 | Vertical transmission of hepatitis C virus and follow-up of newborns from infected mothers. | Minerva ginecologica | Minerva Ginecol | 52 | 3 | null | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND] Aim of the study is to analyze the rate of vertical transmission of HCV and the time of clearance of maternal antibodies in non-infected babies serum. [METHODS] We have studied 36 babies born to HCV-positive and HIV-negative pregnant women at the University of Pavia. All mothers underwent blood tests to ev... | null | 0.131 | 0 | Obstetrics and Gynecology | Medicine | 2,000 |
10,904,820 | EEG changes in 4-week-old lambs in response to castration, tail docking and mulesing. | Australian veterinary journal | Aust Vet J | 78 | 5 | 10.1111/j.1751-0813.2000.tb11789.x | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] To interpret changes in EEG in relation to perceived pain of castration, mulesing and docking in lambs. [DESIGN] Analysis of covariance (randomised block design) to determine the effects of treatment on eight bandwidths of the EEG frequency spectrum. [PROCEDURE] Ninety-eight, 3- to 4-week-old lambs were sub... | null | 0.373 | 71 | Medicine; Veterinary | Medicine; Veterinary | 2,000 |
10,903,600 | A comparative study of the elective treatment of variceal hemorrhage with beta-blockers, transendoscopic sclerotherapy, and surgery: a prospective, controlled, and randomized trial during 10 years. | Annals of surgery | Ann Surg | 232 | 2 | 10.1097/00000658-200008000-00011 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] To compare three options for the elective treatment of portal hypertension during a 10-year period. [METHODS] Patients included in the trial were 18 to 76 years old, had a history of bleeding portal hypertension, and had undergone no prior treatment. Treatment options were beta-blockers (propranolol), scler... | null | 3.51 | 360 | Surgery | Medicine | 2,000 |
10,903,488 | Asthma management in the emergency department. | Canadian respiratory journal | Can Respir J | 7 | 3 | 10.1155/2000/296273 | eng | 2,000 | null | null | null | null | null | [OBJECTIVES] To evaluate various aspects of the management of adult patients who present to the emergency department with acute exacerbations of asthma and who are discharged from the emergency department without hospital admission. Further, to compare the results with accepted management guidelines for the emergency d... | null | 0.498 | 64 | Medicine; Pulmonary and Respiratory Medicine | Medicine | 2,000 |
10,903,406 | Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. | Biological psychiatry | Biol Psychiatry | 48 | 2 | 10.1016/s0006-3223(00)00227-4 | eng | 2,000 | 7 | 15 | null | null | null | [BACKGROUND] Working memory (WM) deficits in schizophrenia have been associated with dorsolateral prefrontal cortex (DLPFC) dysfunction in neuroimaging studies. We previously found increased DLPFC activation in schizophrenic versus normal subjects during WM performance (Manoach et al 1999b). We now have investigated wh... | null | 2.239 | 367 | Biological Psychiatry | Neuroscience | 2,000 |
10,903,071 | Management of contralateral adrenal metastasis from renal cell carcinoma: possibility of inferior vena cava tumour thrombus. | Scandinavian journal of urology and nephrology | Scand J Urol Nephrol | 34 | 2 | 10.1080/003655900750016715 | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVE] The contralateral adrenal gland is a rare metastatic site in renal cell carcinoma (RCC). We describe our experiences with this metastasis in a cohort of 610 radical nephrectomy patients analysed. To our knowledge this study is the first to demonstrate an inferior vena cava tumour thrombus from metachronous ... | null | null | null | null | null | null |
10,903,070 | Intravesical pressure during irrigating fluid absorption in transurethral resection of the prostate. | Scandinavian journal of urology and nephrology | Scand J Urol Nephrol | 34 | 2 | 10.1080/003655900750016706 | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVE] In order to control fluid absorption, various approaches are used to reduce intravesical pressure during transurethral resection of the prostate (TURP). With a view to finding a target pressure for such efforts, pressure and fluid absorption were compared in a meta-analysis of four previous studies comprisi... | null | null | null | null | null | null |
10,903,022 | Suppression of surgical hyperaldosteronism by potassium canrenoate during gynecologic surgery under sevoflurane anesthesia. | Acta anaesthesiologica Scandinavica | Acta Anaesthesiol Scand | 44 | 6 | 10.1034/j.1399-6576.2000.440616.x | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] Surgical hyperaldosteronism leads to sodium and water retention during surgery and often causes postoperative edema. This study investigated the effect of potassium canrenoate (PC) on pituitary adrenocortical function in lower abdominal surgery under sevoflurane anesthesia. [METHODS] Twenty patients were r... | null | 0.896 | 126 | Anesthesiology and Pain Medicine; Medicine | Medicine | 2,000 |
10,902,738 | Inactivation of human normal and tumour cells irradiated with low energy protons. | International journal of radiation biology | Int J Radiat Biol | 76 | 6 | 10.1080/09553000050028995 | eng | 2,000 | 6 | null | null | null | null | [PURPOSE] To analyse the cell inactivation frequencies induced by low energy protons in human cells with different sensitivity to photon radiation. [MATERIALS AND METHODS] Four human cell lines with various sensitivities to photon irradiation were used: the SCC25 and SQ20B derived from human epithelium tumours of the t... | null | 1.055 | 104 | Radiological and Ultrasound Technology; Radiology, Nuclear Medicine and Imaging | Health Professions; Medicine | 2,000 |
10,901,468 | Development of the standard reference plane for the Heidelberg retina tomograph. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie | Graefes Arch Clin Exp Ophthalmol | 238 | 5 | 10.1007/s004170050368 | eng | 2,000 | 5 | null | null | null | null | [BACKGROUND] Topometry of the optic disc is the quantitative assessment of the structure of the optic nerve head by means of three-dimensional parameters. The parameter values depend on definitions of intraocular reference planes. [PURPOSE] To describe the development of intraocular reference planes in laser scanning t... | null | null | null | null | null | null |
10,901,406 | The efficiency of the community dental service in England: a data envelopment analysis. | Community dentistry and oral epidemiology | Community Dent Oral Epidemiol | 28 | 4 | 10.1034/j.1600-0528.2000.280405.x | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVES] To assess the efficiency with which health authorities' Community Dental Services provide dental care in England. [METHODS] A data envelopment analysis of inputs (hours worked by dental officers, therapists, hygienists and others) and outputs (screening, treatment, prevention) of the Community Dental Servi... | null | 1.13 | 118 | Dentistry; Public Health, Environmental and Occupational Health | Dentistry; Medicine | 2,000 |
10,901,116 | Sleep-disordered breathing and occupational accidents. | Scandinavian journal of work, environment & health | Scand J Work Environ Health | 26 | 3 | 10.5271/sjweh.537 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVES] The relationship between a common type of sleep disturbance, sleep-disordered breathing, and the risk of becoming involved in an occupational accident was studied. [METHODS] A 10-year retrospective comparison was made of occupational injuries reported to the Occupational Injury Statistics Division of the S... | null | null | null | null | null | null |
10,900,585 | Vaginal delivery in a woman with limb-girdle muscular dystrophy. A case report. | The Journal of reproductive medicine | J Reprod Med | 45 | 6 | null | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] Limb-girdle muscular dystrophy is a muscular disease determined genetically. Few papers have been published on this disorder in pregnancy. Several authors reported on delivery by cesarean section because of the risk of dystocia. [CASE] A woman with limb-girdle muscular dystrophy had two pregnancies with no... | null | null | null | null | null | null |
10,900,276 | Rapid detection of group B streptococci in pregnant women at delivery. | The New England journal of medicine | N Engl J Med | 343 | 3 | 10.1056/NEJM200007203430303 | eng | 2,000 | 7 | 20 | null | null | null | [BACKGROUND] Group B streptococcal infections are an important cause of neonatal morbidity and mortality. A rapid method for the detection of this organism in pregnant women at the time of delivery is needed to allow early treatment of neonates. [METHODS] We studied the efficacy of two polymerase-chain-reaction (PCR) a... | null | 8.367 | 1,231 | Medicine | Medicine | 2,000 |
10,899,724 | Liver transplantation in primary biliary cirrhosis: risk assessment and 11-year follow-up. | Digestion | Digestion | 62 | 1 | 10.1159/000007776 | eng | 2,000 | null | null | null | null | null | [BACKGROUND/AIMS] Liver transplantation (LTx) is the only established treatment in patients with end-stage primary biliary cirrhosis (PBC). Although short-term survival after LTx in this group of patients is usually good, few data exist on the long-term survival. The optimal timing of transplantation is difficult. Thus... | null | 0.668 | 92 | Gastroenterology | Medicine | 2,000 |
10,898,341 | Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma. | Cancer | Cancer | 88 | 12 Suppl | 10.1002/1097-0142(20000615)88:12+<2979::aid-cncr13>3.0.co;2-u | eng | 2,000 | 6 | 15 | null | null | null | [BACKGROUND] Bone, which abundantly stores a variety of growth factors, provides a fertile soil for cancer cells to develop metastases by supplying these growth factors as a consequence of osteoclastic bone resorption. Accordingly, suppression of osteoclast activity is a primary approach to inhibit bone metastasis, and... | null | 1.528 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,898,319 | Prognosis of alpha-1-antitrypsin deficiency-related liver disease in the era of paediatric liver transplantation. | Journal of hepatology | J Hepatol | 32 | 6 | 10.1016/s0168-8278(00)80103-8 | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND/AIM] Alpha-1-antitrypsin deficiency (alpha1ATD) is the commonest metabolic disease leading to liver transplantation (LT) in children. Approximately 10-15% of the PiZZ population develops liver disease. Five percent of them will require LT within the first 4 years of life. This study aimed to investigate the... | null | 1.219 | 319 | Hepatology | Medicine | 2,000 |
10,898,260 | Physical activity, disability, and the risk of hospitalization for breast cancer among older women. | The journals of gerontology. Series A, Biological sciences and medical sciences | J Gerontol A Biol Sci Med Sci | 55 | 7 | 10.1093/gerona/55.7.m418 | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] A recent investigation of physical activity, disability, and the risk of breast cancer among older women in the Iowa 65 + Rural Health Study reported a decreased risk of breast cancer among women with any disability compared with physically capable but inactive women (relative risk [RR] = 0.4. 95% confiden... | null | 1.037 | 230 | Aging; Geriatrics and Gerontology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,898,071 | Anxiety and depression in a community-based rheumatoid arthritis population. | Scandinavian journal of rheumatology | Scand J Rheumatol | 29 | 3 | 10.1080/030097400750002067 | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] To assess anxiety and depression and their explanatory factors in rheumatoid arthritis (RA) in a community-based population. [METHODS] The subscales of the Arthritis Impact Measurement Scales (AIMS) for anxiety and depression were used, and the Health Assessment Questionnaire (HAQ) was used for the assessme... | null | 0.566 | 88 | Medicine; Immunology and Allergy; Rheumatology; Immunology | Immunology and Microbiology; Medicine | 2,000 |
10,897,075 | Outcome of anorexia nervosa: eating attitudes, personality, and parental bonding. | The International journal of eating disorders | Int J Eat Disord | 28 | 2 | 10.1002/1098-108x(200009)28:2<139::aid-eat2>3.0.co;2-g | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] We examined eating attitudes, personality, and parental bonding in women with a history of anorexia nervosa stratified by degree of recovery in comparison to randomly selected controls. We were interested in the distinguishing characteristics of recovery and of chronic anorexia nervosa. [METHOD] All female... | null | 1.528 | 163 | Psychiatry and Mental Health | Medicine | 2,000 |
10,896,997 | Concomitant chemoradiation treatment in the management of patients with extrahepatic biliary tract recurrence of gastric carcinoma. | Cancer | Cancer | 89 | 1 | null | eng | 2,000 | 7 | 1 | null | null | null | [BACKGROUND] The aim of this study was to determine the role of concomitant chemoradiation in the alleviation of obstructive jaundice in patients with extrahepatic biliary tract metastases from gastric carcinoma. [METHODS] Thirteen patients with good performance status who had obstructive jaundice resulting from extrah... | null | 1.528 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,896,961 | Is it feasible to construct a community profile of exposure to industrial air pollution? | Occupational and environmental medicine | Occup Environ Med | 57 | 8 | 10.1136/oem.57.8.542 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] An epidemiological investigation to assess the validity of residential proximity to industry as a measure of community exposure. [METHODS] 19 Housing estates in Teesside (population 1991: 77 330) in north east England were grouped into zones: A=near; B=intermediate; C=further from industry. With residential... | null | 1.509 | 167 | Public Health, Environmental and Occupational Health | Medicine | 2,000 |
10,896,096 | Factors associated with patients' participation in rehabilitation services: a comparative injury analysis 12 months post-discharge. | Disability and rehabilitation | Disabil Rehabil | 22 | 8 | 10.1080/096382800296601 | eng | 2,000 | 5 | 20 | null | null | null | [PURPOSE] To determine key characteristics or factors associated with rehabilitation participation during the first year following discharge for persons with either traumatic brain injury (TBI), spinal cord injury (SCI), intra-articular fracture (IAF), or burn injury (BURNS). [METHOD] Medical records and longitudinal s... | null | 0.398 | 140 | Rehabilitation | Medicine | 2,000 |
10,895,341 | DNA testing for fragile X syndrome in 255 males from special schools in Singapore. | Annals of the Academy of Medicine, Singapore | Ann Acad Med Singap | 29 | 2 | null | eng | 2,000 | 3 | null | null | null | null | [INTRODUCTION] Fragile X syndrome, the most common cause of inherited mental retardation, results from unstable expansion of a trinucleotide (CGG)n repeat in the FMR1 gene. Phenotypic expression is variable making clinical diagnosis difficult, while diagnosis by Southern blotting is relatively expensive and labour inte... | null | 0.199 | 70 | Medicine | Medicine | 2,000 |
10,894,866 | Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: A trial of the European Organization for Research and Treatment of Cancer/Soft Tissue ... | Journal of clinical oncology : official journal of the American Society of Clinical Oncology | J Clin Oncol | 18 | 14 | 10.1200/JCO.2000.18.14.2676 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] This randomized multicenter study was designed to compare the activity of a high-dose doxorubicin-containing chemotherapy regimen with a conventional standard-dose regimen in adult patients with advanced soft tissue sarcomas (ASTS). [PATIENTS AND METHODS] Between 1992 and 1995, 314 patients were randomized to... | null | 3.972 | 646 | Cancer Research; Medicine; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,894,499 | Deoxyribonucleic acid preparation in polymerase chain reaction genotyping of transgenic mice. | Comparative medicine | Comp Med | 50 | 3 | null | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND AND PURPOSE] In an attempt to find a rapid and reproducible method for routine polymerase chain reaction genotyping of transgenic mice, two novel approaches were developed. [METHODS] One approach allowed reproducible amplification from crude lysates of tail snips, using a thermally activated polymerase. In ... | null | null | null | null | null | null |
10,894,236 | Effects of alcohol on the geographic variation of driver fatalities in motor vehicle crashes. | Academic emergency medicine : official journal of the Society for Academic Emergency Medicine | Acad Emerg Med | 7 | 1 | 10.1111/j.1553-2712.2000.tb01882.x | eng | 2,000 | 1 | null | null | null | null | [OBJECTIVE] To determine whether the increased risk of dying in a rural vs nonrural motor vehicle crash (MVC) can be attributed to driver demographics, crash characteristics, or police-reported alcohol use. [METHODS] A retrospective cohort study was conducted, comparing all rural (116,242) and a 20% random sample of no... | null | 0.851 | 148 | Emergency Medicine; Medicine | Medicine | 2,000 |
10,894,107 | Impact of haze from forest fire to respiratory health: Indonesian experience. | Respirology (Carlton, Vic.) | Respirology | 5 | 2 | 10.1046/j.1440-1843.2000.00246.x | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVE] This paper will describe the impact on the human lung of haze from forest fires in Indonesia based on data collected from different provinces. [METHODOLOGY] Data were collected from personal reports from pulmonologists working in the area as well as from province/district health offices and hospitals. [RESU... | null | 0.165 | 113 | Pulmonary and Respiratory Medicine | Medicine | 2,000 |
10,893,593 | Extensive biopsy protocol improves the detection rate of prostate cancer. | The Journal of urology | J Urol | 164 | 2 | null | eng | 2,000 | 8 | null | null | null | null | [PURPOSE] We evaluated improvement in the rate of prostate cancer detection when using an extensive biopsy protocol involving peripheral cores. [MATERIALS AND METHODS] We prospectively evaluated 303 consecutive men who underwent transrectal ultrasound guided biopsy due to elevated prostate specific antigen (PSA) and/or... | null | 1.751 | 291 | Urology | Medicine | 2,000 |
10,892,930 | Milrinone for long-term pharmacologic support of the status 1 heart transplant candidates. | The Annals of thoracic surgery | Ann Thorac Surg | 69 | 6 | 10.1016/s0003-4975(00)01313-8 | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] We determined the efficacy of long-term therapy with milrinone alone or in combination with inotropic agents in status 1 heart transplant candidates as a pharmacological support until heart transplantation. [METHODS] Hemodynamic and biochemical variables were recorded in 29 status 1 men with symptoms of se... | null | 1.356 | 230 | Cardiology and Cardiovascular Medicine; Pulmonary and Respiratory Medicine; Surgery | Medicine | 2,000 |
10,891,516 | Validity of a set of clinical criteria to rule out injury to the cervical spine in patients with blunt trauma. National Emergency X-Radiography Utilization Study Group. | The New England journal of medicine | N Engl J Med | 343 | 2 | 10.1056/NEJM200007133430203 | eng | 2,000 | 7 | 13 | null | null | null | [BACKGROUND] Because clinicians fear missing occult cervical-spine injuries, they obtain cervical radiographs for nearly all patients who present with blunt trauma. Previous research suggests that a set of clinical criteria (decision instrument) can identify patients who have an extremely low probability of injury and ... | null | 8.367 | 1,231 | Medicine | Medicine | 2,000 |
10,890,969 | The influence of different insufflation pressures during carbon dioxide pneumoperitoneum on the development of pulmonary metastasis in a mouse model. | Surgical endoscopy | Surg Endosc | 14 | 6 | 10.1007/s004640000098 | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] The effects of different insufflation pressures on the development of pulmonary metastasis was investigated in a mouse laparoscopy model. [METHODS] BALB/C mice intravenously inoculated with colon 26 cells were randomized to one of five treatment groups (10 mice per group): pneumoperitoneum at different pre... | null | 1.428 | 178 | Surgery | Medicine | 2,000 |
10,890,672 | Plasma dehydroepiandrosterone levels during experimental endotoxemia and anti-inflammatory therapy in humans. | Critical care medicine | Crit Care Med | 28 | 6 | 10.1097/00003246-200006000-00073 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVE] To measure the effect of experimental endotoxemia and anti-inflammatory therapy on plasma dehydroepiandrosterone (DHEA) levels in humans. [DESIGN] Controlled, randomized, single-blind, prospective clinical study. [SETTING] Monitored unit in research hospital. [SUBJECTS] Twelve healthy volunteers served as t... | null | 0.691 | 315 | Critical Care and Intensive Care Medicine | Medicine | 2,000 |
10,890,654 | Relationship between arterial, mixed venous, and internal jugular carboxyhemoglobin concentrations at low, medium, and high concentrations in a piglet model of carbon monoxide toxicity. | Critical care medicine | Crit Care Med | 28 | 6 | 10.1097/00003246-200006000-00053 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVE] This study tested the hypothesis that mixed venous carboxyhemoglobin concentrations (V-COHb) and internal jugular carboxyhemoglobin concentrations (I-COHb) accurately predict arterial carboxyhemoglobin concentrations (A-COHb). In addition, this study tested the hypothesis that there is a high correlation at... | null | 0.691 | 315 | Critical Care and Intensive Care Medicine | Medicine | 2,000 |
10,889,437 | Effect of topical anti-inflammatory drugs on corneal and limbal wound healing. | Journal of cataract and refractive surgery | J Cataract Refract Surg | 26 | 6 | 10.1016/s0886-3350(00)00364-3 | eng | 2,000 | 6 | null | null | null | null | [PURPOSE] To examine the effect of topical treatment with either steroidal or nonsteroidal anti-inflammatory drugs (NSAIDs) on the wound healing of corneal and limbal incisions using histologic criteria. [SETTING] Loyola University Medical Center, Maywood, Illinois, USA. [METHODS] Eighteen eyes of 9 cats were used for ... | null | 1.883 | 169 | Ophthalmology; Sensory Systems; Surgery | Medicine; Neuroscience | 2,000 |
10,889,168 | Abnormal hepatic sinusoidal bile acid transport in an Amish kindred is not linked to FIC1 and is improved by ursodiol. | Gastroenterology | Gastroenterology | 119 | 1 | 10.1053/gast.2000.8547 | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND AND AIMS] The mechanism for abnormal hepatic bile acid transport was investigated in an 18-month-old Amish boy who presented with pruritus, poor growth, and severe bleeding episodes. Serum bilirubin, gamma-glutamyltranspeptidase, and cholesterol levels were normal, but prothrombin time and partial thrombopl... | null | 3.483 | 482 | Gastroenterology | Medicine | 2,000 |
10,889,003 | Audiovestibular phenotype associated with a COL11A1 mutation in Marshall syndrome. | Archives of otolaryngology--head & neck surgery | Arch Otolaryngol Head Neck Surg | 126 | 7 | 10.1001/archotol.126.7.891 | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] Marshall syndrome is a dominant disorder characterized by craniofacial and skeletal abnormalities, sensorineural hearing loss, myopia, and cataracts, and is associated with splicing mutations in COL11A1. [OBJECTIVE] To determine the auditory and vestibular phenotypes associated with a COL11A1 splicing. [DE... | null | null | null | null | null | null |
11,008,021 | High frequency of long-term culture-initiating cells retain in vivo repopulation and self-renewal capacity. | Experimental hematology | Exp Hematol | 28 | 9 | 10.1016/s0301-472x(00)00507-5 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVE] We wished to test if the long-term culture initiating cell (LTC-IC) assay measures primitive hematopoietic stem cells. An LTC-IC is defined by its ability to repopulate a stromal layer by forming colonies of myeloid cells. A negative well should never have received a stem cell, whereas a positive well shoul... | null | 0.45 | 131 | Hematology; Cancer Research; Cell Biology; Genetics; Molecular Biology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
11,007,225 | Impact of endoscopic ultrasound on the management and outcome of pancreatic carcinoma. | The American journal of gastroenterology | Am J Gastroenterol | 95 | 9 | 10.1111/j.1572-0241.2000.02310.x | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVE] Although endoscopic ultrasound and endoscopic ultrasound-guided fine needle aspiration have been shown to aid in the diagnosis and staging of pancreatic carcinoma, whether the general use of these new techniques impacts the overall management and survival of pancreatic cancer, is less clear. [METHODS] Clini... | null | 1.058 | 296 | Gastroenterology; Hepatology | Medicine | 2,000 |
11,006,214 | A new betaA1-crystallin splice junction mutation in autosomal dominant cataract. | Investigative ophthalmology & visual science | Invest Ophthalmol Vis Sci | 41 | 11 | null | eng | 2,000 | 10 | null | null | null | null | [PURPOSE] To map the locus for autosomal dominant cataracts (ADCs) in a Brazilian family using candidate gene linkage analyses, describe the clinical variability, and identify potential mutations in the human betaA1-crystallin gene (CRYBA1), a candidate gene identified through linkage studies demonstrating cosegregatio... | null | null | null | null | null | null |
11,006,044 | Desmoplastic small round cell tumor with primary ovarian involvement: case report and review. | Gynecologic oncology | Gynecol Oncol | 79 | 1 | 10.1006/gyno.2000.5829 | eng | 2,000 | 10 | null | null | null | null | [BACKGROUND] Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive, malignant neoplasm that has recently been characterized. It has not been associated with a primary visceral organ. In women, cases are even more rare and often have some ovarian involvement. [CASE] An 11-year-old girl presented with abdomin... | null | 0.979 | 192 | Obstetrics and Gynecology; Oncology | Medicine | 2,000 |
11,005,786 | Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: a cross sectional study. | Annals of the rheumatic diseases | Ann Rheum Dis | 59 | 10 | 10.1136/ard.59.10.828 | eng | 2,000 | 10 | null | null | null | null | [BACKGROUND] YKL-40 is a 40 kDa glycoprotein secreted by chondrocytes and synoviocytes. It has been suggested that it is a surrogate marker of synovial inflammation and joint destruction in rheumatoid arthritis (RA) and osteoarthritis (OA) and related to C reactive protein (CRP) serum levels in RA. [OBJECTIVE] To study... | null | 0.932 | 300 | Biochemistry, Genetics and Molecular Biology; Rheumatology; Immunology; Immunology and Allergy | Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine | 2,000 |
11,005,747 | Severe anaemia: implications for functional recovery during rehabilitation. | Disability and rehabilitation | Disabil Rehabil | 22 | 12 | 10.1080/096382800416823 | eng | 2,000 | 8 | 15 | null | null | null | [PURPOSE] This case report examines the hospital course and functional recovery of a geriatric patient with severe anaemia undergoing rehabilitation following total hip replacement. It serves to highlight the need for further study of the impact of anaemia on recovery in the rehabilitation setting as well as the import... | null | 0.398 | 140 | Rehabilitation | Medicine | 2,000 |
11,005,586 | Lack of nuclear apoptosis in cardiomyocytes and increased endothelin-1 levels in a rat heart model of myocardial stunning. | Basic research in cardiology | Basic Res Cardiol | 95 | 4 | 10.1007/s003950070050 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] Reperfusion injury may affect the cardiac NO and endothelin production. We investigated whether 20 min of total ischemia followed by 40 min of reperfusion can induce apoptosis in a Langendorff model of retrogradely perfused rat hearts (37 degrees C; paced at 300/'), and we attempted to correlate these findi... | null | null | null | null | null | null |
11,005,400 | Acute occlusion of the retinal arteries: current concepts and recent advances in diagnosis and management. | Journal of accident & emergency medicine | J Accid Emerg Med | 17 | 5 | 10.1136/emj.17.5.324 | eng | 2,000 | 9 | null | null | null | null | [PURPOSE/BACKGROUND] Central retinal artery occlusion (CRAO) is usually a blinding event, and is not an infrequent presentation to the accident and emergency (A&E) department. The evidence-base in support of current treatment options is weak. [METHODS] This paper reviewed the literature germane to the diagnostic, thera... | null | null | null | null | null | null |
11,004,380 | Excellent coronary perfusion pressure during cardiopulmonary resuscitation is not good enough to ensure long-term survival with good neurologic outcome: a porcine case report. | Resuscitation | Resuscitation | 47 | 1 | 10.1016/s0300-9572(00)00200-8 | eng | 2,000 | 9 | null | null | null | null | [PURPOSE] To report a case of cerebral ischemia confirmed by magnetic resonance imaging after successful cardiopulmonary resuscitation (CPR) complicated by acute respiratory injury. [MATERIALS AND METHODS] After 4 min of cardiac arrest, followed by 3 min of basic life support CPR, a female pig weighing 38 kg received e... | null | 0.985 | 162 | Cardiology and Cardiovascular Medicine; Emergency Medicine; Emergency Nursing | Medicine; Nursing | 2,000 |
11,004,369 | Angiogenesis of endometrial carcinomas assessed by measurement of intratumoral blood flow, microvessel density, and vascular endothelial growth factor levels. | Obstetrics and gynecology | Obstet Gynecol | 96 | 4 | 10.1016/s0029-7844(00)00976-5 | eng | 2,000 | 10 | null | null | null | null | [OBJECTIVE] To evaluate the relationship between blood flow in the tumor assessed by color Doppler ultrasound, microvessel density, and vascular endothelial growth factor levels in endometrial carcinoma. [METHODS] Forty-nine patients undergoing surgery for endometrial carcinoma were enrolled. Transvaginal color Doppler... | null | 1.342 | 268 | Obstetrics and Gynecology | Medicine | 2,000 |
11,004,265 | Appearance of the optic disk and retinal nerve fiber layer in atherosclerosis and arterial hypertension: an experimental study in rhesus monkeys. | American journal of ophthalmology | Am J Ophthalmol | 130 | 1 | 10.1016/s0002-9394(00)00387-1 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] To evaluate changes in the appearance of the optic nerve head and retinal nerve fiber layer of rhesus monkeys with chronic arterial hypertension and atherosclerosis. [METHODS] Color stereoscopic fundus photographs of 25 eyes of 25 rhesus monkeys (mean age +/- SD of 20.4 +/- 1.87 years) with chronic experiment... | null | 1.709 | 221 | Ophthalmology | Medicine | 2,000 |
11,004,258 | Outcome of probing for congenital nasolacrimal duct obstruction in older children. | American journal of ophthalmology | Am J Ophthalmol | 130 | 1 | 10.1016/s0002-9394(00)00388-3 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] To evaluate the role of probing in congenital nasolacrimal duct obstruction in children age 2 years and older and to establish factors predictive of the outcome. [METHODS] The study was a single-center, prospective, interventional case series. Sixty patients with congenital nasolacrimal duct obstruction aged ... | null | 1.709 | 221 | Ophthalmology | Medicine | 2,000 |
11,004,105 | At what age could screening for familial retinoblastoma be stopped? A register based study 1945-98. | The British journal of ophthalmology | Br J Ophthalmol | 84 | 10 | 10.1136/bjo.84.10.1170 | eng | 2,000 | 10 | null | null | null | null | [AIM] To evaluate until what age children in families with retinoblastoma should be screened. [METHODS] A register based cohort (n= 685) study of Dutch retinoblastoma patients (1945-1998). The records of all familial hereditary retinoblastoma patients from 1945 were reviewed and the age at diagnosis and either they wer... | null | 1.323 | 185 | Ophthalmology; Sensory Systems; Cellular and Molecular Neuroscience | Medicine; Neuroscience | 2,000 |
11,003,728 | Use of dipstick tests for the rapid diagnosis of malaria in nonimmune travelers. | Journal of travel medicine | J Travel Med | 7 | 4 | 10.2310/7060.2000.00055 | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Swift diagnosis of falciparum malaria in nonendemic areas is frequently complicated by lack of experience on the side of involved laboratory personnel. Diagnostic tools based on the dipstick principle for the detection of plasmodial histidine-rich protein 2 (HRP-2) (ICT Malaria P.f. (R)) and parasite-speci... | null | 0.613 | 77 | Medicine; Public Health, Environmental and Occupational Health; Infectious Diseases | Medicine | 2,000 |
11,003,273 | The effect of brain tumors on BOLD functional MR imaging activation in the adjacent motor cortex: implications for image-guided neurosurgery. | AJNR. American journal of neuroradiology | AJNR Am J Neuroradiol | 21 | 8 | null | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND AND PURPOSE] Functional MR (fMR) imaging data coregistered to a neurosurgical navigation system have been proposed as guides for the resection of brain tumor in or adjacent to eloquent cortices. The purpose of this study was to compare data obtained from the side of the brain affected by tumor with the cont... | null | null | null | null | null | null |
11,003,188 | Injuries in child care centers: gender-environment interactions. | Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention | Inj Prev | 6 | 3 | 10.1136/ip.6.3.214 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVES] To examine child characteristics (age, gender) and child care center environments (socioemotional quality, physical safety) that jointly predict injuries for preschool children. [METHODS] A two year prospective study of 360 preschool children, ages 2-6 years, was conducted in four urban child care centers.... | null | 0.577 | 99 | Public Health, Environmental and Occupational Health | Medicine | 2,000 |
11,002,222 | Time trends of cutaneous melanoma in Queensland, Australia and Central Europe. | Cancer | Cancer | 89 | 6 | 10.1002/1097-0142(20000915)89:6<1269::aid-cncr11>3.0.co;2-c | eng | 2,000 | 9 | 15 | null | null | null | [BACKGROUND] The objective of this study was to describe recent developments in cutaneous melanoma from the German speaking countries in Europe (Germany, Austria, and Switzerland) and from Queensland, Australia. [METHODS] All incident invasive cutaneous melanoma cases recorded between 1986 and 1996 by the Queensland Me... | null | 1.528 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
11,002,221 | B7 costimulatory molecules from malignant cells in patients with b-cell chronic lymphoproliferative disorders trigger t-cell proliferation. | Cancer | Cancer | 89 | 6 | null | eng | 2,000 | 9 | 15 | null | null | null | [BACKGROUND] B7 family molecules are involved in T-B-cell communications after interaction with their ligands CD28 and CD152. They play a key role in costimulatory mechanisms and during antigen presentation by efficient antigen presenting cells. B7 molecules are usually absent or expressed at low intensity on B lymphoc... | null | 1.528 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,973,636 | Comparison of the effects of two methods of cryopreservation on testicular sperm DNA. | Fertility and sterility | Fertil Steril | 74 | 3 | 10.1016/s0015-0282(00)00680-4 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVE] To assess the effects of two methods of freezing on testicular sperm DNA from subjects with obstructive azoospermia and to compare these with samples of fresh and freeze-thawed testicular sperm from fertile men. [DESIGN] The Comet assay was used to determine the percentage of undamaged DNA in fresh testicul... | null | 1.515 | 252 | Obstetrics and Gynecology; Reproductive Medicine | Medicine | 2,000 |
11,001,589 | Identification of sites phosphorylated by the vaccinia virus B1R kinase in viral protein H5R. | BMC biochemistry | BMC Biochem | 1 | null | 10.1186/1471-2091-1-2 | eng | 2,000 | null | null | 2,000 | 9 | 5 | [BACKGROUND] Vaccinia virus gene B1R encodes a serine/threonine protein kinase. In vitro this protein kinase phosphorylates ribosomal proteins Sa and S2 and vaccinia virus protein H5R, proteins that become phosphorylated during infection. Nothing is known about the sites phosphorylated on these proteins or the general ... | null | null | null | null | null | null |
11,001,419 | Organization of orthopaedic trauma services: a survey of the Orthopaedic Trauma Association. | Journal of orthopaedic trauma | J Orthop Trauma | 14 | 6 | 10.1097/00005131-200008000-00010 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVES] This study was undertaken to collect information about the organization of orthopaedic trauma services in different types of hospitals, with particular emphasis on hospital support arrangements in different practice situations. [DESIGN] A survey was sent to all members of the Orthopaedic Trauma Association... | null | 1.016 | 150 | Medicine; Orthopedics and Sports Medicine; Sports Science; Surgery | Health Professions; Medicine | 2,000 |
11,001,410 | Radiographic fracture assessments: which ones can we reliably make? | Journal of orthopaedic trauma | J Orthop Trauma | 14 | 6 | 10.1097/00005131-200008000-00001 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] To identify the fracture characteristics that can be reliably assessed by analysis of plain radiographs of tibial plateau fractures. [DESIGN] Radiographic review study. [PARTICIPANTS] Five orthopaedic traumatologists served as observers. [INTERVENTION] Observers made assessments based on the radiographs of ... | null | 1.016 | 150 | Medicine; Orthopedics and Sports Medicine; Sports Science; Surgery | Health Professions; Medicine | 2,000 |
11,001,103 | Persistently positive cultures and outcome in invasive neonatal candidiasis. | The Pediatric infectious disease journal | Pediatr Infect Dis J | 19 | 9 | 10.1097/00006454-200009000-00003 | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] A persistently positive culture >24 h after starting antibiotic therapy has been correlated with adverse outcome in several invasive bacterial infections, but few reports address persistent positivity and outcome in infections caused by fungi and other pathogens that replicate more slowly and therefore may... | null | 1.291 | 160 | Infectious Diseases; Microbiology; Pediatrics, Perinatology and Child Health | Medicine | 2,000 |
11,001,004 | Impact of an electronic medical record system on community-based primary care practices. | The Journal of the American Board of Family Practice | J Am Board Fam Pract | 13 | 5 | null | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Although primary care physicians are increasingly interested in adopting electronic medical record (EMR) systems, few use such systems in practice. This study explores the organizational impact of an EMR system on community-based practices that have overcome the initial barriers and are experienced EMR use... | null | null | null | null | null | null |
11,000,563 | Enteropathic arthritis in the sacroiliac joint. Imaging and differential diagnosis. | European journal of radiology | Eur J Radiol | 35 | 3 | 10.1016/s0720-048x(00)00243-6 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVES] A new high resolution computed tomography (HRCT) scoring system of sacroiliac joint (SIJ) involvement in enteropathic arthritis is introduced. [PATIENTS AND METHODS] SIJ's of 100 patients were studied. A total of 25 patients presented with pain syndrome, 25 with suspicious seronegative spondylarthritis, 25... | null | 0.454 | 139 | Medicine; Radiology, Nuclear Medicine and Imaging | Medicine | 2,000 |
11,000,366 | Experimental development and validation of a technique for lumboendoscopic anterior fusion of lumbar spine fractures: comparison of endoscopic and open surgery in a live porcine model. | Surgical endoscopy | Surg Endosc | 14 | 9 | 10.1007/s004640000221 | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] Using a porcine model, this study describes the feasibility of a lumboendoscopically guided approach to the lumbar spine for anterior interbody fusion, and compares the results with that of the open procedure. The objectives of this study were to develop a minimally invasive approach to the lumbar spine fo... | null | 1.428 | 178 | Surgery | Medicine | 2,000 |
11,000,184 | Prostate vascular flow: the effect of ejaculation as revealed on transrectal power Doppler sonography. | AJR. American journal of roentgenology | AJR Am J Roentgenol | 175 | 4 | 10.2214/ajr.175.4.1751169 | eng | 2,000 | 10 | null | null | null | null | [OBJECTIVE] The objective of our study was to determine the effect of ejaculation on prostate vascular flow. [SUBJECTS AND METHODS] Using power Doppler technology, we performed four transrectal sonographic examinations before and immediately, 6 hr, and 24 hr after ejaculation in 10 healthy volunteers. Images were asses... | null | null | null | null | null | null |
10,999,881 | Scrotal temperature is increased in disposable plastic lined nappies. | Archives of disease in childhood | Arch Dis Child | 83 | 4 | 10.1136/adc.83.4.364 | eng | 2,000 | 10 | null | null | null | null | [OBJECTIVES] Male reproductive health has deteriorated in recent decades. It is proposed that increased testicular temperature in early childhood, due to the use of modern disposable plastic lined nappies (diapers), could be an important factor contributing to this decline. [STUDY DESIGN] Scrotal skin temperature was m... | null | 0.891 | 169 | Pediatrics, Perinatology and Child Health | Medicine | 2,000 |
10,999,556 | A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures. | Epilepsia | Epilepsia | 41 | 9 | 10.1111/j.1528-1157.2000.tb00322.x | eng | 2,000 | 9 | null | null | null | null | [PURPOSE] This study compares the cognitive effects of topiramate (TPM) with those of valproate (VPA) using efficacious doses of each drug when used as adjunctive therapy to carbamazepine (CBZ). A key question of the study is to what extent a more gradual introduction of TPM improves tolerability and prevents cognitive... | null | 1.453 | 228 | Neurology; Neurology | Medicine; Neuroscience | 2,000 |
10,999,531 | Chromogranins in temporal lobe epilepsy. | Epilepsia | Epilepsia | 41 Suppl 6 | null | 10.1111/j.1528-1157.2000.tb01568.x | eng | 2,000 | null | null | null | null | null | [PURPOSE] Chromogranins are neuropeptide precursors stored in large dense core vesicles. Because physiological functions have been postulated for peptides originating from chromogranins, we investigated the distribution of chromogranins A and B and secretoneurin (a peptide derived from secretogranin II) in the control ... | null | 1.453 | 228 | Neurology; Neurology | Medicine; Neuroscience | 2,000 |
10,997,810 | A dose escalating study of topotecan preceding cisplatin in previously untreated patients with small-cell lung cancer. | Annals of oncology : official journal of the European Society for Medical Oncology | Ann Oncol | 11 | 7 | 10.1023/a:1008393512479 | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] The aim was to define the MTD of topotecan (TPT) given before cisplatin in patients with previously untreated SCLC. [PATIENTS AND METHODS] Alternating cycles A and B to a total of 6 cycles were given. Cycle A: TPT days 1-5 and cisplatin (50 mg/m2) day 5. Cycle B consisted of teniposide, carboplatin, vincri... | null | 1.005 | 311 | Hematology; Medicine; Oncology | Medicine | 2,000 |
10,997,700 | Role of vascular endothelial growth factor in diabetic vascular complications. | Kidney international. Supplement | Kidney Int Suppl | 77 | null | 10.1046/j.1523-1755.2000.07718.x | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] Much of the morbidity and mortality associated with diabetes mellitus predominantly reflects its deleterious effects on microcirculation and macrocirculation. During the past few years, rapid advancement has been made in our understanding of the mechanisms and molecules involved in the pathogenesis of diab... | null | null | null | null | null | null |
10,997,699 | Role of vascular endothelial growth factor in diabetic nephropathy. | Kidney international. Supplement | Kidney Int Suppl | 77 | null | 10.1046/j.1523-1755.2000.07717.x | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] Vascular endothelial growth factor (VEGF) is a potent cytokine that is considered to be an important mediator in the pathogenesis of endothelial dysfunction in diabetes. [METHODS] This study investigates the effect of high glucose on the signaling and production of VEGF in rat mesangial cells in culture an... | null | null | null | null | null | null |
10,996,579 | Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis. | The American journal of medicine | Am J Med | 109 | 4 | 10.1016/s0002-9343(00)00507-6 | eng | 2,000 | 9 | null | null | null | null | [PURPOSE] Viable bacteria are often isolated from airway secretions in clinically stable patients with chronic bronchitis. We hypothesized that the number of organisms and bacterial species might be important modulators of airway inflammation. [SUBJECTS AND METHODS] We performed quantitative sputum cultures in 160 stab... | null | 1.609 | 262 | Medicine | Medicine | 2,000 |
10,996,232 | Tympanometry and acoustic reflectometry in ears with chronic retraction without effusion. | International journal of pediatric otorhinolaryngology | Int J Pediatr Otorhinolaryngol | 55 | 1 | 10.1016/s0165-5876(00)00367-0 | eng | 2,000 | 9 | 15 | null | null | null | [OBJECTIVE] Purpose of this study was to find out test accuracy and predictivity of tympanometry (TYMP) and parameters (reflectivity and curve angle) of acoustic reflectometry (AR) in the ears with prior clinic and otoscopic evidences of effusion in which no effusion was detected by myringotomy, by comparing with the d... | null | 0.477 | 96 | Medicine; Otorhinolaryngology; Pediatrics, Perinatology and Child Health | Medicine | 2,000 |
10,994,035 | Flutamide-hydroxypropy-beta-chiyclodextrin complex: formulation, physical characterization, and absorption studies using the Caco-2 in vitro model. | Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques | J Pharm Pharm Sci | 3 | 2 | null | eng | 2,000 | null | null | null | null | null | [PURPOSE] The objective of this research was to formulate flutamide (FLT) in hydroxypropyl-beta-cyclodextrin (HPbetaCyD), and to investigate FLT transcellular permeation from the complex using the Caco-2 monolayer in vitro model. [METHODS] Classical solubility data were used to derive thermodynamic parameters which, to... | null | null | null | null | null | null |
10,993,540 | MR imaging of simple bone cysts in children: not so simple. | Pediatric radiology | Pediatr Radiol | 30 | 8 | 10.1007/s002470000258 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] The unicameral bone cyst (UBC) is a common cystic bone lesion seen in children. We review and summarize its MR findings, focusing on their appearance following contrast enhancement, and correlating them to known histologic features of UBC. [SUBJECTS AND METHODS] A retrospective review of 20 cases (13 boys, ... | null | 0.479 | 104 | Pediatrics, Perinatology and Child Health; Radiology, Nuclear Medicine and Imaging | Medicine | 2,000 |
10,993,456 | Air-bone gap and resonant frequency in large vestibular aqueduct syndrome. | The American journal of otology | Am J Otol | 21 | 5 | null | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] Conductive hearing loss is occasionally recognized in large vestibular aqueduct (LVA) syndrome; however, the incidence rate and the cause are not known. [OBJECTIVE] To compare air and bone conduction levels between patients with LVA syndrome and those with idiopathic sudden sensorineural hearing loss, and ... | null | null | null | null | null | null |
10,993,445 | External canal cholesteatoma. | The American journal of otology | Am J Otol | 21 | 5 | null | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVE] External canal cholesteatoma (ECC) may develop spontaneously or as a consequence of infection, trauma, or surgery. There is little information on the relative incidence of ECC according to cause. An analysis of cases was conducted to compare the clinical, surgical, and radiographic features of different typ... | null | null | null | null | null | null |
10,993,096 | Increased perinatal mortality among sub-Saharan immigrants in a city-population in Sweden. | Acta obstetricia et gynecologica Scandinavica | Acta Obstet Gynecol Scand | 79 | 9 | null | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] The aim of the study was to investigate whether the maternal country of origin affected the risk for perinatal mortality and to determine its relationship to risk factors. [METHODS] A study of 15,639 deliveries in Malmö, Sweden. Data regarding demographic factors, life-style and perinatal risk factors, tog... | null | 0.723 | 126 | Medicine; Obstetrics and Gynecology | Medicine | 2,000 |
10,992,260 | FGF-2-induced imbalance in early embryonic heart cell proliferation: a potential cause of late cardiovascular anomalies. | Teratology | Teratology | 62 | 4 | 10.1002/1096-9926(200010)62:4<189::AID-TERA4>3.0.CO;2-7 | eng | 2,000 | 10 | null | null | null | null | [BACKGROUND] This laboratory previously demonstrated that placement of fibroblast growth factor-2 (FGF-2)-soaked beads adjacent to the developing ventricle at stage 24 caused cardiovascular anomalies by embryonic day 15. We sought to characterize early cellular changes that may suggest mechanisms for the abnormalities ... | null | null | null | null | null | null |
10,992,192 | The mechanisms underlying the stimulatory effects of thrombin on myometrial smooth muscle. | American journal of obstetrics and gynecology | Am J Obstet Gynecol | 183 | 3 | 10.1067/mob.2000.106751 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVE] The mechanisms underlying the stimulation of uterine contractions in the presence of intrauterine hemorrhage have not been well defined. Thrombin, a blood coagulation factor, activates membrane receptors to result in the stimulation of the phosphatidylinositol signaling pathway and the mobilization of cytos... | null | 1.624 | 274 | Obstetrics and Gynecology | Medicine | 2,000 |
10,990,502 | Neurological manifestations in chronic mountain sickness: the burning feet-burning hands syndrome. | Journal of neurology, neurosurgery, and psychiatry | J Neurol Neurosurg Psychiatry | 69 | 4 | 10.1136/jnnp.69.4.447 | eng | 2,000 | 10 | null | null | null | null | [OBJECTIVE] To characterise the clinical features and nerve biopsy findings in patients with chronic mountain sickness (CMS) living in the Peruvian Andes, with particular attention to the occurrence of the "burning feet-burning hands" syndrome. [METHODS] Symptoms and signs were documented clinically in 10 patients with... | null | 1.317 | 244 | Neurology; Psychiatry and Mental Health; Surgery | Medicine | 2,000 |
10,990,196 | Transdermal macromolecular delivery: real-time visualization of iontophoretic and chemically enhanced transport using two-photon excitation microscopy. | Pharmaceutical research | Pharm Res | 17 | 7 | 10.1023/a:1007595822786 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] To investigate the transdermal delivery of a model macromolecule by passive and iontophoretic means following pretreatment with C12-penetration enhancers and to visualise transport across human stratum corneum (SC) in real time. [METHODS] Transport studies of dextran, labelled with fluorescent Cascade Blue (D... | null | 1.067 | 235 | Biotechnology; Organic Chemistry; Pharmaceutical Science; Pharmacology; Pharmacology; Molecular Medicine | Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,000 |
10,990,104 | Effect of dopamine on gastrointestinal motility during critical illness. | Intensive care medicine | Intensive Care Med | 26 | 7 | 10.1007/s001340051279 | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] To document the action of dopamine on gastrointestinal motility in mechanically ventilated patients. [DESIGN] Crossover, randomized, placebo-controlled study. [SETTING] General intensive care unit (ICU) in a university hospital. [PATIENTS] Twelve mechanically ventilated patients in a stable hemodynamic cond... | null | 0.904 | 246 | Critical Care and Intensive Care Medicine | Medicine | 2,000 |
10,988,190 | Oxygen supplementation and cardiac-autonomic modulation in COPD. | Chest | Chest | 118 | 3 | 10.1378/chest.118.3.691 | eng | 2,000 | 9 | null | null | null | null | [STUDY OBJECTIVES] Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO(2)) on autonomic modulation in a group of COPD patients. [DESIGN] We measured autonomic modulation before and during the ... | null | 1.002 | 337 | Cardiology and Cardiovascular Medicine; Critical Care and Intensive Care Medicine; Pulmonary and Respiratory Medicine | Medicine | 2,000 |
10,988,188 | The cumulative effect of long-acting bronchodilators, exercise, and inspiratory muscle training on the perception of dyspnea in patients with advanced COPD. | Chest | Chest | 118 | 3 | 10.1378/chest.118.3.672 | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] Dyspnea is a common complaint during daily activities in patients with advanced COPD. The mechanisms underlying dyspnea and the appropriate treatment strategies to relieve it are still not totally understood. We hypothesized that the perception of dyspnea (POD) may be modified by the accumulative effect of... | null | 1.002 | 337 | Cardiology and Cardiovascular Medicine; Critical Care and Intensive Care Medicine; Pulmonary and Respiratory Medicine | Medicine | 2,000 |
10,987,895 | The correlation between ventricular diameter measured by transcranial sonography and clinical disability and cognitive dysfunction in patients with multiple sclerosis. | Archives of neurology | Arch Neurol | 57 | 9 | 10.1001/archneur.57.9.1289 | eng | 2,000 | 9 | null | null | null | null | [CONTEXT] Magnetic resonance imaging (MRI) data suggest that the extent of brain atrophy in patients with multiple sclerosis (MS) is related to the severity of disease. [OBJECTIVE] To evaluate whether ventricular diameter determined by transcranial sonography (TCS) is a marker of brain atrophy and is correlated with di... | null | null | null | null | null | null |
10,987,407 | Unilateral diaphragmatic agenesis precluding laparoscopic cholecystectomy. | JSLS : Journal of the Society of Laparoendoscopic Surgeons | JSLS | 4 | 3 | null | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Complete absence of a hemidiaphragm or diaphragmatic agenesis in adulthood is rare with only one previous report in the literature. Its significance in relation to performing laparoscopic procedures has not been documented previously. [METHODS] We report a case of previously undiagnosed diaphragmatic agene... | null | null | null | null | null | null |
10,986,313 | A diagnostic algorithm for carpal tunnel syndrome based on Bayes's theorem. | Rheumatology (Oxford, England) | Rheumatology (Oxford) | 39 | 9 | 10.1093/rheumatology/39.9.1040 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVE] To construct a diagnostic algorithm based on Bayes's theorem and using simple clinical tests to allow accurate diagnosis without resort to nerve conduction studies. [METHOD] A cohort of patients being referred with possible carpal tunnel syndrome had clinical and electrophysiological testing, from which the... | null | 1.021 | 205 | Pharmacology; Rheumatology | Medicine | 2,000 |
10,986,311 | Remission and response to early treatment of RA assessed by the Disease Activity Score. BARFOT study group. Better Anti-rheumatic Farmacotherapy. | Rheumatology (Oxford, England) | Rheumatology (Oxford) | 39 | 9 | 10.1093/rheumatology/39.9.1031 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVE] To assess criteria for individual response and remission based on the Disease Activity Score (DAS) in patients with RA participating in a long-term observational study. [METHODS] The EULAR (European League against Rheumatism) criteria for individual response and a recently proposed remission criterion, DAS ... | null | 1.021 | 205 | Pharmacology; Rheumatology | Medicine | 2,000 |
10,986,030 | Randomised double-blind placebo controlled trial of topical autologous platelet lysate in venous ulcer healing. | European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery | Eur J Vasc Endovasc Surg | 20 | 3 | 10.1053/ejvs.2000.1134 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVES] to assess the effect of topical autologous platelet lysate on the healing of chronic venous ulcers. [DESIGN] a randomised placebo controlled double-blind trial. [MATERIALS] all patients had blood taken for preparation of autologous platelet lysate. [METHODS] patients with proven chronic venous ulceration w... | null | 1.128 | 144 | Cardiology and Cardiovascular Medicine; Surgery | Medicine | 2,000 |
10,985,710 | Cardiogenic shock with non-ST-segment elevation myocardial infarction: a report from the SHOCK Trial Registry. SHould we emergently revascularize Occluded coronaries for Cardiogenic shocK? | Journal of the American College of Cardiology | J Am Coll Cardiol | 36 | 3 Suppl A | 10.1016/s0735-1097(00)00888-3 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVES] We sought to determine the outcomes of patients with cardiogenic shock (CS) complicating non-ST-segment elevation acute myocardial infarction (MI). [BACKGROUND] Such patients represent a high-risk (ST-segment depression) or low-risk (normal or nonspecific electrocardiographic findings) group for whom optim... | null | 4.278 | 512 | Cardiology and Cardiovascular Medicine | Medicine | 2,000 |
10,985,707 | The clinical profile of patients with suspected cardiogenic shock due to predominant left ventricular failure: a report from the SHOCK Trial Registry. SHould we emergently revascularize Occluded Coronaries in cardiogenic shocK? | Journal of the American College of Cardiology | J Am Coll Cardiol | 36 | 3 Suppl A | 10.1016/s0735-1097(00)00874-3 | eng | 2,000 | 9 | null | null | null | null | [OBJECTIVES] We sought to evaluate the frequency of pulmonary congestion and associated clinical and hemodynamic findings in patients with suspected cardiogenic shock (CS). [BACKGROUND] The prevalence of pulmonary congestion in the setting of CS is uncertain. [METHODS] The 571 SHOCK Trial Registry patients with predomi... | null | 4.278 | 512 | Cardiology and Cardiovascular Medicine | Medicine | 2,000 |
10,985,383 | A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. | Current biology : CB | Curr Biol | 10 | 16 | 10.1016/s0960-9822(00)00640-0 | eng | 2,000 | 8 | 24 | null | null | null | [BACKGROUND] A polarised cytoskeleton is required to pattern cellular space, and for many aspects of cell behaviour. While the mechanisms ordering the actin cytoskeleton have been extensively studied in yeast, little is known about the analogous processes in other organisms. We have used Drosophila oogenesis as a model... | null | null | null | null | null | null |
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