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10,831,634 | Aminoglycosides and renal magnesium homeostasis in humans. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | Nephrol Dial Transplant | 15 | 6 | 10.1093/ndt/15.6.822 | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] The use of aminoglycosides has been linked with hypomagnesaemia in scattered reports. The objective of the study was to measure prospectively the effect of treatment with the aminoglycoside amikacin on renal magnesium homeostasis. [METHODS] Twenty-four cystic fibrosis patients (aged 9-19 years) admitted be... | null | 0.657 | 203 | Medicine; Nephrology; Transplantation | Medicine | 2,000 |
10,831,485 | Effect of cognitive impairment and premorbid intelligence on treatment preferences for life-sustaining medical therapy. | The American journal of psychiatry | Am J Psychiatry | 157 | 6 | 10.1176/appi.ajp.157.6.1009 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVE] This study examines the influence of cognitive impairment, premorbid intelligence, and decision-making capacity to complete advance directives on the treatment preferences for life-sustaining medical therapy in the elderly. [METHOD] One hundred elderly individuals were recruited. Fifty were first referrals ... | null | 3.887 | 405 | Psychiatry and Mental Health | Medicine | 2,000 |
10,831,360 | Human immunodeficiency virus infection and invasive cervical cancer in South Africa. | Gynecologic oncology | Gynecol Oncol | 77 | 3 | 10.1006/gyno.2000.5775 | eng | 2,000 | 6 | null | null | null | null | [PURPOSE] The goal of this study was to determine whether South African HIV-seropositive women with invasive cervical cancer present with disease that is more advanced than that of HIV-seronegative women and whether degree of immunosuppression affects the extent of disease at initial presentation. [METHODS] This study ... | null | 0.979 | 192 | Obstetrics and Gynecology; Oncology | Medicine | 2,000 |
10,830,672 | A systematic review of the content and quality of wrist outcome instruments. | International journal for quality in health care : journal of the International Society for Quality in Health Care | Int J Qual Health Care | 12 | 2 | 10.1093/intqhc/12.2.149 | eng | 2,000 | 4 | null | null | null | null | [OBJECTIVE] To assess the content and quality of published wrist outcome instruments using standardized criteria. [DESIGN] An analytical study that examined 32 wrist outcome instruments sourced from textbooks, Medline (1951 to present) and Current Contents. [MAIN MEASURES] The content of each instrument was classified ... | null | 0.459 | 113 | Health Policy; Medicine; Public Health, Environmental and Occupational Health | Medicine | 2,000 |
10,830,240 | Administration of equine anti-thymocyte globulin via peripheral vein in renal transplant recipients. | Transplantation | Transplantation | 69 | 9 | 10.1097/00007890-200005150-00038 | eng | 2,000 | 5 | 15 | null | null | null | [BACKGROUND] Anti-thymocyte globulin (ATG) is used frequently as induction therapy in renal transplant recipients. It has been standard practice that the various polyclonal anti-lymphocyte preparations be administered via central line, vascular shunt, or arteriovenous fistula to avoid thrombophlebitis. [METHODS] We hav... | null | 2.115 | 224 | Transplantation | Medicine | 2,000 |
10,830,226 | Donor liver uridine diphosphate (UDP)-glucuronosyltransferase-1A1 deficiency causing Gilbert's syndrome in liver transplant recipients. | Transplantation | Transplantation | 69 | 9 | 10.1097/00007890-200005150-00024 | eng | 2,000 | 5 | 15 | null | null | null | [BACKGROUND] Uridine diphosphate-glucuronosyltransferase-1A1 deficiency, causing Gilbert's syndrome, has been attributed to two extra (TA) bases in the TATAA-box of the promoter region of its gene, where the A(TA)6TAA allele corresponds to the normal gene and A(TA)7TAA corresponds to a gene with reduced expression. Our... | null | 2.115 | 224 | Transplantation | Medicine | 2,000 |
10,828,682 | Biological response modifiers for the treatment of superficial bladder tumors. | European urology | Eur Urol | 37 Suppl 3 | null | 10.1159/000052387 | eng | 2,000 | null | null | null | null | null | [BACKGROUND] For more than 20 years, superficial bladder tumors have been demonstrated to be sensitive to several biological response modifiers and especially to immunomodulators. The best-known and studied immunomodulator is the bacillus Calmette-Guérin (BCG). However, despite its well-recognized efficacy, BCG is not ... | null | 1.126 | 274 | Urology | Medicine | 2,000 |
10,828,630 | Male-pattern hair loss in Norwegian men: a community-based study. | Dermatology (Basel, Switzerland) | Dermatology | 200 | 3 | 10.1159/000018386 | eng | 2,000 | null | null | null | null | null | [BACKGROUND] A Norwegian community study was conducted as an add-on to a large general health survey in Trondlag County, Norway, to characterize the cross-sectional relationship of patient perceptions with the degree of hair loss. [METHODS] All members of the community were invited to participate in the general health ... | null | 0.597 | 110 | Dermatology | Medicine | 2,000 |
10,827,410 | Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma. | Journal of the American Academy of Dermatology | J Am Acad Dermatol | 42 | 6 | null | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] Several clinical studies have focused on the therapeutic effects of interferon gamma (IFN-gamma) in patients with severe atopic dermatitis (AD), although the dosage of recombinant IFN-gamma (rIFN-gamma), therapeutic schedule, and the degree of clinical improvement were different among studies. Although the... | null | 1.201 | 256 | Dermatology | Medicine | 2,000 |
10,827,406 | Topical corticosteroid in foam vehicle offers comparable coverage compared with traditional vehicles. | Journal of the American Academy of Dermatology | J Am Acad Dermatol | 42 | 6 | null | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] A new preparation of betamethasone valerate in a novel foam vehicle is available for treatment of scalp dermatoses. The vehicle spreads between hair until it reaches the scalp, where it melts and delivers the active drug. Solids make up only a tiny fraction of the foam vehicle, leaving no apparent residue ... | null | 1.201 | 256 | Dermatology | Medicine | 2,000 |
10,827,398 | Altered basic fibroblast growth factor expression in common epidermal neoplasms: examination with in situ hybridization and immunohistochemistry. | Journal of the American Academy of Dermatology | J Am Acad Dermatol | 42 | 6 | null | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] The fibroblast growth factor family consists of acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), and Kaposi fibroblast growth factor (kFGF). The distribution of these growth factors in skin disease has not been determined. [OBJECTIVE] The purpose of this study was to determine... | null | 1.201 | 256 | Dermatology | Medicine | 2,000 |
10,827,372 | Proteinuria is a key determinant of death in patients with diabetes after isolated coronary artery bypass grafting. | American heart journal | Am Heart J | 139 | 6 | 10.1067/mhj.2000.105699 | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] Proteinuria is a marker for underlying diabetic nephropathy and may be a surrogate marker for advanced atherosclerosis. It is unknown if proteinuria is a determinant of death in patients with diabetes after coronary artery bypass grafting. We hypothesized that diabetic patients with evidence of proteinuria... | null | 1.441 | 211 | Cardiology and Cardiovascular Medicine | Medicine | 2,000 |
10,827,318 | Practical training for postgraduate year 1 surgery residents. | American journal of surgery | Am J Surg | 179 | 3 | 10.1016/s0002-9610(00)00305-6 | eng | 2,000 | 3 | null | null | null | null | [BACKGROUND] Surgical interns accept significant patient care responsibilities with minimal orientation. We have developed a multifaceted training program for incoming surgical interns in which learning in a simulated environment plays a key role. The purpose of this study was to evaluate resident perceptions of simula... | null | 1.194 | 173 | Medicine; Surgery | Medicine | 2,000 |
10,826,582 | Views of Finnish doctors on fetal screening. | BJOG : an international journal of obstetrics and gynaecology | BJOG | 107 | 5 | 10.1111/j.1471-0528.2000.tb13309.x | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] To investigate the views of Finnish doctors concerning fetal screening. [DESIGN] Anonymous, questionnaire survey conducted in 1996-1997. [POPULATION] A representative sample of gynaecologists, paediatricians and general practitioners in Finland. Both leading doctors and ordinary practitioners were included.... | Empirical Approach; Genetics and Reproduction | 1.395 | 195 | Obstetrics and Gynecology | Medicine | 2,000 |
10,826,572 | High risk human papillomavirus in women with normal cervical cytology prior to the development of abnormal cytology and colposcopy. | BJOG : an international journal of obstetrics and gynaecology | BJOG | 107 | 5 | 10.1111/j.1471-0528.2000.tb13299.x | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] To study the significance of the presence of high risk human papillomavirus (HPV) in women with initially normal cervical cytology for the development of abnormal cytology and an abnormal colposcopic impression. [DESIGN] Prospective, observational study [PARTICIPANTS AND METHODS] Sixty-eight women with cyto... | null | 1.395 | 195 | Obstetrics and Gynecology | Medicine | 2,000 |
10,825,711 | The cause of slowed forearm median conduction velocity in carpal tunnel syndrome. | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology | Clin Neurophysiol | 111 | 6 | 10.1016/s1388-2457(00)00288-1 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVES] Attempting to answer a debate concerning the etiopathogenesis of the decreased forearm median motor conduction velocity (FMMCV), we tried to use proximal stimulation at the wrist, elbow, mid-arm and axillary regions to determine segmental median motor conduction velocity (MMCV). We also correlated the FMMC... | null | 0.606 | 230 | Neurology; Neurology; Physiology; Sensory Systems | Medicine; Neuroscience | 2,000 |
10,947,304 | The cost effectiveness of misoprostol prophylaxis alongside long-term nonsteroidal anti-inflammatory drugs. Implications of the MUCOSA trial. | PharmacoEconomics | Pharmacoeconomics | 17 | 3 | 10.2165/00019053-200017030-00007 | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] This study considered the cost effectiveness of misoprostol prophylaxis for nonsteroidal anti-inflammatory drug (NSAID)-induced gastrointestinal damage, using data from the Misoprostol Ulcer Complications Outcomes Safety Assessment (MUCOSA) trial. The initial aim was to gain listing of misoprostol on the Au... | null | 0.623 | 124 | Health Policy; Public Health, Environmental and Occupational Health; Pharmacology | Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,000 |
10,947,018 | Most important lymph node information in gastric cancer: multivariate prognostic study. | Annals of surgical oncology | Ann Surg Oncol | 7 | 7 | 10.1007/s10434-000-0503-1 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] In gastric cancer, the level and number of lymph node metastases is useful for predicting survival, and there are several staging systems for lymph node metastasis. The aim of this study was to compare the several lymph node classifications and to clarify the most important lymph node information associate... | null | 1.158 | 210 | Oncology; Surgery | Medicine | 2,000 |
10,946,200 | Dye-enhanced cataract surgery. Part 2: learning critical steps of phacoemulsification. | Journal of cataract and refractive surgery | J Cataract Refract Surg | 26 | 7 | 10.1016/s0886-3350(00)00363-1 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] To use capsule dyes to enhance visualization to learn and perform various critical steps of the phacoemulsification procedure in a laboratory setting using postmortem human eyes. [SETTING] Center for Research on Ocular Therapeutics and Biodevices, Storm Eye Institute, Medical University of South Carolina, Cha... | null | 1.883 | 169 | Ophthalmology; Sensory Systems; Surgery | Medicine; Neuroscience | 2,000 |
10,946,189 | Effect of lamellar flap location on corneal topography after laser in situ keratomileusis. | Journal of cataract and refractive surgery | J Cataract Refract Surg | 26 | 7 | 10.1016/s0886-3350(00)00414-4 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] To investigate the effect of hinge position on corneal topography after laser in situ keratomileusis (LASIK) for myopia. [SETTING] Academic center and refractive surgery practice. [METHODS] Topography data obtained from 89 eyes of 46 patients after LASIK were analyzed. Using a system of Cartesian coordinates,... | null | 1.883 | 169 | Ophthalmology; Sensory Systems; Surgery | Medicine; Neuroscience | 2,000 |
10,945,954 | Laparoscopic suturing evaluation among surgical residents. | The Journal of surgical research | J Surg Res | 93 | 1 | 10.1006/jsre.2000.5969 | eng | 2,000 | 9 | null | null | null | null | [BACKGROUND] Laparoscopic suturing is an integral part of advanced laparoscopic surgery training. The objective of this study was to evaluate the performance and preference of surgical residents performing intracorporeal and extracorporeal knot-tying techniques using conventional and Endo Stitch instruments. The reside... | null | 0.786 | 131 | Surgery | Medicine | 2,000 |
10,945,314 | Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking. | Clinical pharmacology and therapeutics | Clin Pharmacol Ther | 68 | 1 | 10.1067/mcp.2000.107651 | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] Nicotine establishes and maintains tobacco dependence. Individuals with genetically deficient CYP2A6 nicotine metabolism are at lower risk to become smokers and, if dependent, will smoke fewer cigarettes. Hepatic CYP2A6 accounts for nicotine's low systemic bioavailability, precluding oral nicotine replacem... | null | null | null | null | null | null |
10,943,754 | Rehabilitation of neck-shoulder pain in women industrial workers: a randomized trial comparing isometric shoulder endurance training with isometric shoulder strength training. | Archives of physical medicine and rehabilitation | Arch Phys Med Rehabil | 81 | 8 | 10.1053/apmr.2000.7582 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVES] To study whether isometric shoulder endurance was more advantageous than isometric shoulder strength training in reducing pain and perceived exertion and to increase shoulder function through improved muscle endurance and strength. [DESIGN] Randomized trial. [SETTING] Three occupational health care centers... | null | 0.838 | 225 | Physical Therapy, Sports Therapy and Rehabilitation; Rehabilitation; Sports Science | Health Professions; Medicine | 2,000 |
10,943,678 | Synthesis of hyaluronan by normal and wounded rabbit iris. | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie | Graefes Arch Clin Exp Ophthalmol | 238 | 6 | 10.1007/pl00007894 | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] Endogenous hyaluronan has been found in different tissues in the normal and traumatized eye. However, the main source, the biological aspects and the full potential role of hyloronan are still unclear. [METHODS] Hyaluronan production was studied both in organ culture and in vivo, using a double-label proto... | null | null | null | null | null | null |
10,943,575 | A comparative investigation of contraceptive reliability, cycle control and tolerance of two monophasic oral contraceptives containing either drospirenone or desogestrel. | The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception | Eur J Contracept Reprod Health Care | 5 | 2 | 10.1080/13625180008500387 | eng | 2,000 | 6 | null | null | null | null | [OBJECTIVE] To assess the contraceptive reliability, cycle control and tolerance of a new monophasic oral contraceptive (Yasmin) containing 30 microg ethinylestradiol and 3 mg drospirenone and compare it with a preparation containing an equal dose of ethinylestradiol combined with 150 microg desogestrel (Marvelon). [ME... | null | null | null | null | null | null |
10,942,485 | Estrogen augments the vasodilatory effects of vascular endothelial growth factor in the uterine circulation of the rat. | American journal of obstetrics and gynecology | Am J Obstet Gynecol | 183 | 2 | 10.1067/mob.2000.105910 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] Pregnancy augments uterine artery vasodilatation in response to vascular endothelial growth factor, although the underlying mechanism is not known. The aim of this study was to test the hypothesis that estrogen and progesterone, the primary sex steroids of pregnancy, are responsible for this effect through ... | null | 1.624 | 274 | Obstetrics and Gynecology | Medicine | 2,000 |
10,942,144 | In vivo measurements of temporal bone on reconstructed clinical high-resolution computed tomography scans. | The Laryngoscope | Laryngoscope | 110 | 8 | 10.1097/00005537-200008000-00029 | eng | 2,000 | 8 | null | null | null | null | [PURPOSE] To retrospectively assess the accuracy of measurements of temporal bone anatomy made from reconstructed clinical high-resolution computed tomography (HRCT) scans. [METHODS] Nine HRCT scans were performed on unselected clinical cases in which the subjects had a temporal bone study judged to be normal. The orbi... | null | 1.349 | 183 | Otorhinolaryngology | Medicine | 2,000 |
10,941,544 | Increased platelet activation and endothelial dysfunction in patients with atrial fibrillation immediately following percutaneous balloon mitral valvuloplasty. | Clinical cardiology | Clin Cardiol | 23 | 8 | 10.1002/clc.4960230808 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Immediately following percutaneous balloon mitral valvuloplasty (PBMVP), patients have a 3% risk of systemic thromboembolism. [HYPOTHESIS] We hypothesized that this may in part be due to an increase in hypercoagulability (as indicated by abnormal coagulation, platelet activation, and endothelial dysfunctio... | null | 0.648 | 89 | Medicine; Cardiology and Cardiovascular Medicine | Medicine | 2,000 |
10,940,144 | Postmenopausal estrogen therapy and depressive symptoms in older women. | Journal of general internal medicine | J Gen Intern Med | 15 | 8 | 10.1046/j.1525-1497.2000.04029.x | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Evidence regarding the effect of postmenopausal estrogen therapy on mood is limited. [METHODS] To determine whether postmenopausal estrogen therapy is associated with fewer depressive symptoms in elderly women, we conducted a cross-sectional study of 6, 602 white women ages 71 years or older who were recru... | null | 1.62 | 224 | Internal Medicine | Medicine | 2,000 |
10,940,095 | Assessing the relative incidence of mitochondrial DNA A3243G in migraine without aura with maternal inheritance. | Headache | Headache | 40 | 7 | 10.1046/j.1526-4610.2000.00088.x | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] To determine whether patients with migraine without aura with maternal "inheritance" are affected by a monosymptomatic form of the MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes) or carry the most common mitochondrial DNA (mtDNA) mutation associated with MELAS, nam... | null | 0.805 | 146 | Neurology; Neurology | Medicine; Neuroscience | 2,000 |
10,939,601 | 5-fluorouracil plus folinic acid with or without ifosfamide in advanced colorectal cancer: a phase II randomized trial. | Tumori | Tumori | 86 | 3 | 10.1177/030089160008600307 | eng | 2,000 | null | null | null | null | null | [AIM] This phase II trial evaluated the biomodulation of 5-fluorouracil (5-FU) plus folinic acid (FA) with or without ifosfamide (IFO) in chemotherapy-naive patients with colorectal cancer. [PATIENTS AND METHODS] Forty-eight patients were randomized to receive: FA (25 mg/m2 iv bolus days 1 to 3), followed by 5-FU (750 ... | null | 0.243 | 59 | Medicine; Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,939,534 | Transcriptional regulation of IL-5 gene by nontransformed human T cells through the proximal promoter element. | Internal medicine (Tokyo, Japan) | Intern Med | 39 | 8 | 10.2169/internalmedicine.39.618 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] IL-5 is strongly involved in the eosinophilic inflammation in bronchial asthma and atopic dermatitis. We have previously reported that IL-5 synthesis in atopic and nonatopic asthmatics is significantly enhanced compared to control subjects. T cell IL-5 synthesis is regulated through several transcriptional ... | null | 0.249 | 83 | Medicine; Internal Medicine | Medicine | 2,000 |
10,938,173 | The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System. | JAMA | JAMA | 284 | 7 | 10.1001/jama.284.7.843 | eng | 2,000 | 8 | 16 | null | null | null | [CONTEXT] The World Health Organization defines preterm birth as birth at less than 37 completed gestational weeks, but most studies have focused on very preterm infants (birth at <32 weeks) because of their high risk of mortality and serious morbidity. However, infants born at 32 through 36 weeks are more common and t... | null | null | null | null | null | null |
10,938,143 | Temporoparietal fascial flap in orbital reconstruction. | Archives of facial plastic surgery | Arch Facial Plast Surg | 2 | 3 | 10.1001/archfaci.2.3.196 | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] To evaluate the success of the temporoparietal fascial flap (TPFF) in the primary or secondary reconstruction of difficult orbital defects and to review the surgical techniques. [DESIGN] Retrospective analysis. [SETTING] Tertiary medical center. [PATIENTS] Nine patients with diverse orbital cavity or perior... | null | null | null | null | null | null |
10,938,049 | Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. | BMJ (Clinical research ed.) | BMJ | 321 | 7258 | 10.1136/bmj.321.7258.412 | eng | 2,000 | 8 | 12 | null | null | null | [OBJECTIVE] To determine the relation between systolic blood pressure over time and the risk of macrovascular or microvascular complications in patients with type 2 diabetes. [DESIGN] Prospective observational study. [SETTING] 23 hospital based clinics in England, Scotland, and Northern Ireland. [PARTICIPANTS] 4801 whi... | null | 1.122 | 519 | Medicine | Medicine | 2,000 |
10,937,606 | Effects of donepezil on emotional/behavioral symptoms in Alzheimer's disease patients. | The Journal of clinical psychiatry | J Clin Psychiatry | 61 | 7 | 10.4088/jcp.v61n0705 | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] This open-label study examined the effects of the reversible cholinesterase inhibitor donepezil on emotional/behavioral symptoms in Alzheimer's disease (AD) patients. [METHOD] Patients were diagnosed as having probable/possible AD by National Institute of Neurological and Communicative Disorders and Stroke... | null | 2.106 | 236 | Medicine; Psychiatry and Mental Health | Medicine | 2,000 |
10,937,573 | Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells. | Investigative ophthalmology & visual science | Invest Ophthalmol Vis Sci | 41 | 9 | null | eng | 2,000 | 8 | null | null | null | null | [PURPOSE] Herpetic stromal keratitis (HSK) is a T-cell-mediated inflammatory disease initiated by a herpes simplex virus (HSV) infection of the cornea. Recently, studies in the HSK mouse model have shown that the immunopathogenic T cells are directed against the HSV protein UL6 cross-reacting with an unknown corneal au... | null | null | null | null | null | null |
10,937,004 | A national burden of disease calculation: Dutch disability-adjusted life-years. Dutch Burden of Disease Group. | American journal of public health | Am J Public Health | 90 | 8 | 10.2105/ajph.90.8.1241 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVES] This study estimated the burden of disease due to 48 major causes in the Netherlands in 1994 in disability-adjusted life-years (DALYs), using national epidemiologic data and disability weights, and explored associated problems and uncertainties. [METHODS] We combined data from Dutch vital statistics, regis... | null | 2.126 | 321 | Public Health, Environmental and Occupational Health | Medicine | 2,000 |
10,934,949 | Clinical significance of atypical glandular cells of undetermined significance. A follow-up study from an academic medical center. | Acta cytologica | Acta Cytol | 44 | 4 | 10.1159/000328530 | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] To determine the rate of atypical glandular cells of undetermined significance (AGUS) and the incidence of subsequent clinically significant lesions. [STUDY DESIGN] A computer-based search of our cytology laboratory files was performed for cervicovaginal smears diagnosed as AGUS from January 1996 to Decembe... | null | 0.647 | 67 | Medicine; Histology; Pathology and Forensic Medicine | Medicine | 2,000 |
10,934,456 | Family association studies of markers on chromosome 2q and Type 1 diabetes in subjects from South India. | Diabetes/metabolism research and reviews | Diabetes Metab Res Rev | 16 | 4 | 10.1002/1520-7560(200007/08)16:4<276::aid-dmrr128>3.0.co;2-w | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Several Type 1 diabetes susceptibility loci have been located to chromosome 2q12-21. However, results have not always been consistent and this may reflect study design and the population analysed. We have used a family-based design to look for an association between Type 1 diabetes and markers located to 2... | null | 0.874 | 141 | Internal Medicine; Endocrinology; Endocrinology, Diabetes and Metabolism | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,933,288 | Colorado family practice graduates' preparation for and practice of emergency medicine. | The Journal of the American Board of Family Practice | J Am Board Fam Pract | 13 | 4 | 10.3122/15572625-13-4-246 | eng | 2,000 | null | null | null | null | null | [BACKGROUND] Family physicians provide care in emergency departments, especially in rural areas; however, no published data describe how they perceive their preparation for emergency practice. We surveyed graduates of Colorado family practice residencies concerning their emergency medicine practice, their comfort worki... | null | null | null | null | null | null |
10,933,160 | Prolongation of liver allograft survival after interleukin-10 gene transduction 24-48 hours before donation. | Transplantation | Transplantation | 70 | 2 | 10.1097/00007890-200007270-00018 | eng | 2,000 | 7 | 27 | null | null | null | [BACKGROUND] Interleukin- (IL) 10 may be a potent regulator for controlling of allograft rejection. A single administration of IL-10 is not effective for controlling graft rejection. Gene transfer is an attractive vehicle for prolonging the expression of short-lived proteins. [METHODS] Donor or recipient livers were tr... | null | 2.115 | 224 | Transplantation | Medicine | 2,000 |
10,932,072 | Evidence for expression of eosinophil-associated IL-12 messenger RNA and immunoreactivity in bronchial asthma. | The Journal of allergy and clinical immunology | J Allergy Clin Immunol | 106 | 2 | 10.1067/mai.2000.107932 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Eosinophils are a source of cytokines within the airways of asthmatic individuals that may exert an important immunoregulatory influence. [OBJECTIVES] We examined IL-12 messenger (m)RNA and protein expression in eosinophils from peripheral blood and bronchoalveolar lavage (BAL) fluid obtained from subjects... | null | 1.942 | 350 | Immunology; Immunology and Allergy | Immunology and Microbiology; Medicine | 2,000 |
10,931,214 | Frequent presence of neuroendocrine small cells in thymic carcinoma: a light microscopic and immunohistochemical study. | Histopathology | Histopathology | 37 | 1 | 10.1046/j.1365-2559.2000.00935.x | eng | 2,000 | 7 | null | null | null | null | [AIMS] Neuroendocrine differentiation has been described in conventional carcinomas of various organs. Small cells postulated to be neuroendocrine cells were observed previously in some thymic carcinomas. This study was conducted to confirm and characterize the presence of neuroendocrine small cells in thymic carcinoma... | null | 0.945 | 145 | Histology; Medicine; Pathology and Forensic Medicine | Medicine | 2,000 |
10,931,105 | Effects of successful parathyroidectomy on altered arterial reactivity in patients with hypercalcaemia: results of a 3-year follow-up study. | Clinical endocrinology | Clin Endocrinol (Oxf) | 53 | 2 | 10.1046/j.1365-2265.2000.01076.x | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] Serum calcium was found to be an independent, prospective risk factor for myocardial infarction. We have previously shown that altered arterial reactivity in the course of primary hyperparathyroidism, a disease characterized by hypercalcaemia, may predominantly involve the arterial media and not the endothe... | null | 1.04 | 169 | Endocrinology, Diabetes and Metabolism | Medicine | 2,000 |
10,931,083 | Vasopressin and thirst in patients with posterior pituitary ectopia and hypopituitarism. | Clinical endocrinology | Clin Endocrinol (Oxf) | 53 | 1 | 10.1046/j.1365-2265.2000.01030.x | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] Partial diabetes insipidus has been documented in patients with congenital hypopituitarism and posterior pituitary ectopia, some cases being clinically silent except for enuresis. The objective of our study was to evaluate vasopressin (AVP) secretion and thirst appreciation in hypopituitary patients with po... | null | 1.04 | 169 | Endocrinology, Diabetes and Metabolism | Medicine | 2,000 |
10,930,916 | Genetic identification of bilateral primary or metastatic nonpapillary renal cell carcinoma. | BJU international | BJU Int | 86 | 3 | 10.1046/j.1464-410x.2000.00770.x | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] To clarify the clonality of bilateral tumours by genetic analysis of bilateral renal cell carcinomas (RCCs) using the VHL gene, which is inactivated in approximately 60% of RCCs and which plays a causal role in the development of most cases of nonpapillary RCC. [PATIENTS AND METHODS] The study included 20 p... | null | 0.469 | 174 | Urology | Medicine | 2,000 |
10,930,488 | Outcomes of laparoscopic antireflux procedures. | American journal of surgery | Am J Surg | 179 | 5 | 10.1016/s0002-9610(00)00363-9 | eng | 2,000 | 5 | null | null | null | null | [BACKGROUND] Laparoscopy has increased the number of patients undergoing operative correction of gastroesophageal reflux disease (GERD). Symptom improvement has been most commonly reported as the means to assess operative outcome. We compared symptomatic outcome to postoperative pH testing at short-term follow-up to de... | null | 1.194 | 173 | Medicine; Surgery | Medicine | 2,000 |
10,930,376 | Role of Na(+)HCO(3)(-) cotransporter NBC1, Na(+)/H(+) exchanger NHE1, and carbonic anhydrase in rabbit duodenal bicarbonate secretion. | Gastroenterology | Gastroenterology | 119 | 2 | 10.1053/gast.2000.9358 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND AND AIMS] HCO(3)(-) supply to the enterocyte is rate limiting for duodenal HCO(3)(-) secretion (J(HCO3-)). This study defines the molecular nature of the major HCO(3)(-) uptake pathways in rabbit duodenocytes and investigates their physiologic significance and regulation during basal and stimulated J(HCO3-)... | null | 3.483 | 482 | Gastroenterology | Medicine | 2,000 |
10,930,366 | "Atypical p-ANCA" in IBD and hepatobiliary disorders react with a 50-kilodalton nuclear envelope protein of neutrophils and myeloid cell lines. | Gastroenterology | Gastroenterology | 119 | 2 | 10.1053/gast.2000.9366 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND AND AIMS] Atypical "antineutrophil cytoplasmic antibodies" (ANCA) are present in patients with ulcerative colitis (UC), primary sclerosing cholangitis (PSC), and autoimmune hepatitis (AIH). Recently, we showed that atypical p-ANCA react with nuclear envelope proteins of neutrophils. Based on this observatio... | null | 3.483 | 482 | Gastroenterology | Medicine | 2,000 |
10,930,200 | Gastric distension and ventilation during laparoscopic cholecystectomy: LMA-Classic vs. tracheal intubation. | Canadian journal of anaesthesia = Journal canadien d'anesthesie | Can J Anaesth | 47 | 7 | 10.1007/BF03018993 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] The standard laryngeal mask airway LMA-Classic was designed as an alternative to the endotracheal tube (ETT) or the face mask for use with either spontaneous or positive pressure ventilation. Positive pressure ventilation may exploit leaks around the LMA cuff, leading to gastric distension and/or inadequate v... | null | null | null | null | null | null |
10,929,963 | The effect of tamoxifen on the endometrium, serum lipids and hypothalamus pituitary axis in the postmenopausal breast cancer patients. | Acta obstetricia et gynecologica Scandinavica | Acta Obstet Gynecol Scand | 79 | 7 | null | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] There is still no cost-effective endometrial screening method for asymptomatic postmenopausal breast cancer patients using tamoxifen. We investigated the effectivity of transvaginal ultrasonography and endometrial sampling as a screening method for asymptomatic patients. Additionally the effect of tamoxife... | null | 0.723 | 126 | Medicine; Obstetrics and Gynecology | Medicine | 2,000 |
10,929,903 | Increased presence of cells containing transforming growth factor alpha (TGF-alpha) in ulcerative colitis, both during active inflammation and in remission. | European journal of gastroenterology & hepatology | Eur J Gastroenterol Hepatol | 12 | 7 | 10.1097/00042737-200012070-00008 | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] Patients with extensive and long-standing ulcerative colitis have an increased risk of developing colorectal cancer and sub-epithelial fibrosis. The polypeptide transforming growth factor alpha (TGF-alpha) has mitogenic effects and it is believed that local overproduction may result in tumour formation and ... | null | null | null | null | null | null |
10,929,360 | Reliability of cranial CT versus intracerebral pressure measurement for the evaluation of generalised cerebral oedema in children. | Pediatric radiology | Pediatr Radiol | 30 | 7 | 10.1007/s002470000255 | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] To examine the extent to which intracranial pressure (ICP) in children after severe brain trauma can be determined by cranial CT. [MATERIALS AND METHODS] Two experienced paediatric radiologists, without any knowledge of the clinical symptoms, evaluated 124 CT scans from 65 children (average age 5.4 years) w... | null | 0.479 | 104 | Pediatrics, Perinatology and Child Health; Radiology, Nuclear Medicine and Imaging | Medicine | 2,000 |
10,928,771 | High-risk corneal allografts are capable of stimulating complement dependent cytolytic antibodies. | Cornea | Cornea | 19 | 4 | 10.1097/00003226-200007000-00024 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] To prospectively characterize serum antibody responses in high-risk corneal allografts. [METHODS] Orthotopic and heterotopic C3H (H-2k) corneas were transplanted to CB6F1 (H-2b/d) recipient mice. Individual serum samples were collected at days 7, 14, 21, and 28 from orthotopically and heterotopically grafted ... | null | 1.12 | 141 | Ophthalmology | Medicine | 2,000 |
10,928,397 | Olanzapine-induced glucose dysregulation. | The Annals of pharmacotherapy | Ann Pharmacother | 34 | 7-8 | 10.1345/aph.19327 | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] To report a patient who developed severe exacerbation of type 2 diabetes mellitus after the initiation of olanzapine therapy. [CASE SUMMARY] A 54-year-old African-American woman developed severe glucose dysregulation 12 days after the initiation of olanzapine. Prior to starting olanzapine therapy, the patie... | null | 0.598 | 125 | Medicine; Pharmacology | Medicine | 2,000 |
10,928,114 | Oncoselective transduction of CD80 and CD86 in tumor cell lines using an autonomous recombinant parvovirus. | Anticancer research | Anticancer Res | 20 | 3A | null | eng | 2,000 | null | null | null | null | null | [BACKGROUND] The aim of this study was to enhance selectively the immunostimulatory properties of tumor cells. Based on their oncotropic properties, we used autonomous recombinant parvoviruses to transduce the genes coding for the constimulatory molecules CD80 (B7-1) or CD86 (B7-2) specifically into tumor cells without... | null | null | null | null | null | null |
10,927,056 | Type VI collagen expression during growth of human ovarian follicles. | Fertility and sterility | Fertil Steril | 74 | 2 | 10.1016/s0015-0282(00)00618-x | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] To identify type VI collagen expression in human ovarian follicles during follicular growth. [DESIGN] In vitro experiment. [SETTING] Department of Obstetrics and Gynecology, Wakayama Medical College, Japan. [PATIENT(S)] Regularly cycling women who underwent adnexectomy. [INTERVENTION(S)] Immunohistochemistr... | null | 1.515 | 252 | Obstetrics and Gynecology; Reproductive Medicine | Medicine | 2,000 |
10,926,894 | Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation: observations in two cosmonauts. | Clinical chemistry | Clin Chem | 46 | 8 Pt 1 | null | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Microgravity induces bone loss by mechanism(s) that remain largely unknown. [METHODS] We measured biochemical markers related to bone remodeling in two cosmonauts before, during, and after 21- and 180-day space flights, respectively. [RESULTS] During both flights, type I procollagen propeptide and bone alk... | null | 1.222 | 248 | Biochemistry; Clinical Biochemistry | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,926,812 | Langerhans' cell histiocytosis on the vulva. | Gynecologic oncology | Gynecol Oncol | 78 | 2 | 10.1006/gyno.2000.5836 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Langerhans' cell histiocytosis (LCH) affecting the vulva alone is rare. At present, there are 51 published cases of LCH affecting the genital area. Of these, only 7 had LCH located in the genital area alone; in these cases, there was no subsequent systemic spread of the disease. A report of the 8th such ca... | null | 0.979 | 192 | Obstetrics and Gynecology; Oncology | Medicine | 2,000 |
10,926,800 | Endometrial histopathology in 700 patients treated with tamoxifen for breast cancer. | Gynecologic oncology | Gynecol Oncol | 78 | 2 | 10.1006/gyno.2000.5859 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] The aim of this study was the evaluation of endometrial histopathologic findings from 700 patients treated with tamoxifen (Tx) for breast cancer from two medical centers (United States and France). [METHODS] A retrospective review of data including histologic slides from 134 hysterectomies and 566 endometri... | null | 0.979 | 192 | Obstetrics and Gynecology; Oncology | Medicine | 2,000 |
10,925,989 | Outcome of patients with chronic abdominal pain referred to chronic pain clinic. | The American journal of gastroenterology | Am J Gastroenterol | 95 | 7 | 10.1111/j.1572-0241.2000.02170.x | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] We determined the outcome of patients with chronic abdominal pain of unknown etiology referred by gastroenterologists to a chronic pain clinic. [METHODS] A retrospective chart review of 43 consecutive patients seen by a university-based gastroenterology group was referred to our Chronic Pain Clinic for eval... | null | 1.058 | 296 | Gastroenterology; Hepatology | Medicine | 2,000 |
10,925,549 | Effectiveness of an organ-sharing program in providing zero HLA-A,B,DR mismatched kidneys for transplantation in Taiwan. | Journal of the Formosan Medical Association = Taiwan yi zhi | J Formos Med Assoc | 99 | 6 | null | eng | 2,000 | 6 | null | null | null | null | [PURPOSE] This study evaluated the effects of organ sharing on the allocation of kidneys from cadaveric donors to uremic patients from National Cheng Kung University Hospital (CKUH) and National Taiwan University Hospital (NTUH) who were waiting for kidney transplantation. [METHODS] Standard complement-dependent microc... | null | null | null | null | null | null |
10,925,336 | Current perspectives on the management of hypertriglyceridemia. | American heart journal | Am Heart J | 140 | 2 | 10.1067/mhj.2000.108001 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Observational studies have demonstrated that triglycerides are an independent risk factor for coronary heart disease. Atherothrombosis may be mediated by uptake and incorporation of triglyceride-rich lipoproteins by macrophages and through an association with small, dense LDL and HDL particles. There are c... | null | 1.441 | 211 | Cardiology and Cardiovascular Medicine | Medicine | 2,000 |
10,925,056 | Utility of red blood cell apheresis in autologous blood donation. | Transfusion science | Transfus Sci | 23 | 1 | 10.1016/s0955-3886(00)00065-5 | eng | 2,000 | 8 | null | null | null | null | [UNLABELLED] Although autologous blood donation is an alternative to allogeneic transfusion, some authors had questioned its cost-effectiveness. New techniques, like red blood cell apheresis could improve the cost-effectiveness of autologous blood transfusion, therefore we have valued the efficiency of this procedure i... | null | null | null | null | null | null |
10,924,630 | Laparoscopic treatment of hydrosalpinx: factors affecting pregnancy rate. | The Journal of the American Association of Gynecologic Laparoscopists | J Am Assoc Gynecol Laparosc | 7 | 3 | 10.1016/s1074-3804(05)60479-3 | eng | 2,000 | 8 | null | null | null | null | [STUDY OBJECTIVE] To evaluate the efficacy of laparoscopic surgery in a series of women with hydrosalpinx. [DESIGN] Prospective, observational study (Canadian Task Force classification II-2). Setting. University-affiliated hospital. [PATIENTS] Sixty-one women undergoing bilateral neosalpingostomy and restoration of tub... | null | null | null | null | null | null |
10,924,616 | Detection of HLA antibodies by using flow cytometry and latex beads coated with HLA antigens. | Transfusion | Transfusion | 40 | 7 | 10.1046/j.1537-2995.2000.40070861.x | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] Detection of HLA class I antibodies in sera is needed in various clinical situations. The standard method for detecting HLA class I antibodies is the complement-dependent lymphocytotoxicity (CDC) assay, but solid-phase assays are now available. [STUDY DESIGN AND METHODS] This study assessed the ability of ... | null | 1.209 | 153 | Hematology; Immunology; Immunology and Allergy | Immunology and Microbiology; Medicine | 2,000 |
10,919,028 | Initial experience with the harmonic scalpel in liver surgery. | Hepato-gastroenterology | Hepatogastroenterology | 47 | 33 | null | eng | 2,000 | null | null | null | null | null | [BACKGROUND/AIMS] Hepatectomies are generally performed using a crushing clamp or by finger fracture. New instruments such as ultrasonic aspirators or water jet dissectors are increasingly used for precise dissection of intrahepatic structures. An ultrasonically activated scalpel has been introduced, mainly for laparos... | null | 0.504 | 84 | Gastroenterology; Medicine; Hepatology | Medicine | 2,000 |
10,918,706 | Fatality trends in United Nations Peacekeeping Operations, 1948-1998. | JAMA | JAMA | 284 | 5 | 10.1001/jama.284.5.598 | eng | 2,000 | 8 | 2 | null | null | null | [CONTEXT] The rising number of deaths among United Nations (UN) peacekeeping forces after the Cold War has made some troop-contributing countries hesitant to participate in peacekeeping operations. While the number and scale of missions have increased, no data have demonstrated a parallel increase in risks to peacekeep... | null | null | null | null | null | null |
10,918,278 | Multiparameter analysis of progeny of individual cells by laser scanning cytometry. | Cytometry | Cytometry | 40 | 4 | 10.1002/1097-0320(20000801)40:4<271::aid-cyto3>3.0.co;2-c | eng | 2,000 | 8 | 1 | null | null | null | [BACKGROUND] Effectiveness of antitumor drugs to suppress unrestricted proliferation of cancer cells is commonly measured by cell clonogenicity assays. Assays of clonogenicity are also used in studies of stem/progenitor cells and in analysis of carcinogenic transformation. The conventional assays are limited to providi... | null | null | null | null | null | null |
10,918,164 | Patterns of detection in patients with cutaneous melanoma. | Cancer | Cancer | 89 | 2 | 10.1002/1097-0142(20000715)89:2<342::aid-cncr19>3.0.co;2-p | eng | 2,000 | 7 | 15 | null | null | null | [BACKGROUND] Despite the importance of early detection in preventing mortality from melanoma, little is known regarding how patients with the disease come to diagnosis. [METHODS] The authors prospectively evaluated 471 newly diagnosed melanoma patients between 1995 and 1998. Patients completed a questionnaire that incl... | null | 1.528 | 349 | Cancer Research; Oncology | Biochemistry, Genetics and Molecular Biology; Medicine | 2,000 |
10,917,984 | The influence of gender on outcome after ruptured abdominal aortic aneurysm. | Journal of vascular surgery | J Vasc Surg | 32 | 2 | 10.1067/mva.2000.106948 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] The influence of gender on the management of coronary artery disease is well documented, but few reports exist regarding the influence of gender on the management of peripheral arterial disease. [OBJECTIVE] The purpose of this study was to examine the influence of gender on selection for and short-term and... | null | 2.213 | 225 | Cardiology and Cardiovascular Medicine; Surgery | Medicine | 2,000 |
10,917,381 | Hyperventilation associated with quetiapine. | The Annals of pharmacotherapy | Ann Pharmacother | 34 | 3 | 10.1345/aph.19232 | eng | 2,000 | 3 | null | null | null | null | [OBJECTIVE] To describe a case of hyperventilation associated with the administration of quetiapine. [CASE SUMMARY] A 69-year-old African-American woman admitted to a psychiatric hospital for treatment of major depression with psychotic features was treated and successfully discharged with quetiapine, along with metron... | null | 0.598 | 125 | Medicine; Pharmacology | Medicine | 2,000 |
10,917,282 | An in vitro comparison of cordopexy, cordopexy and laryngoplasty, and laryngoplasty for treatment of equine laryngeal hemiplegia. | Veterinary surgery : VS | Vet Surg | 29 | 4 | 10.1053/jvet.2000.5599 | eng | 2,000 | null | null | null | null | null | [OBJECTIVE] To examine the effect of cordopexy, laryngoplasty, and cordopexy combined with a modified laryngoplasty on airway mechanics. [STUDY DESIGN] Experimental airway mechanics were determined by subjecting equine cadaveric larynges to airflows similar to inspiratory airflow of exercising horses. [ANIMALS OR SAMPL... | null | 0.818 | 94 | Veterinary | Veterinary | 2,000 |
10,923,609 | Nitrate anaphylaxis. | Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology | Ann Allergy Asthma Immunol | 85 | 1 | 10.1016/S1081-1206(10)62438-6 | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] Nitrate and nitrite salts are commonly used to preserve and sustain color in a number of processed meats. To date there have been no described cases of anaphylaxis to either nitrates or nitrites in the literature. [OBJECTIVE] We report a patient with anaphylaxis to nitrates and nitrites documented by doubl... | null | null | null | null | null | null |
10,922,992 | Hypertonic saline solution induces prostacyclin production by increasing cyclooxygenase-2 expression. | Surgery | Surgery | 128 | 2 | 10.1067/msy.2000.107606 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Previously, we demonstrated that hypertonic saline solution (HTS) and endotoxin (lipopolysaccharide [LPS]) induce prostacyclin (PGI(2)) production in human endothelial cells. Here, we hypothesized that HTS and LPS may induce PGI(2) production by increasing cyclooxygenase (COX) expression. We further examin... | null | null | null | null | null | null |
10,922,346 | Survey into health problems of elderly people: a comparison of self-report with proxy information. | International journal of epidemiology | Int J Epidemiol | 29 | 4 | 10.1093/ije/29.4.684 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] This study was conducted as part of the Medical Research Council Cognitive Function and Ageing Study. [OBJECTIVE] To compare information given by elderly people on their past and current health and family history of illness with similar information obtained from a relative, friend or carer. [DESIGN] Screen... | null | 1.398 | 256 | Epidemiology; Medicine | Medicine | 2,000 |
10,921,550 | The weaning continuum use of Acute Physiology and Chronic Health Evaluation III, Burns Wean Assessment Program, Therapeutic Intervention Scoring System, and Wean Index scores to establish stages of weaning. | Critical care medicine | Crit Care Med | 28 | 7 | 10.1097/00003246-200007000-00013 | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] To determine whether four stages of weaning (acute, prewean, wean, and outcome) could be identified by using clinical instruments designed to quantify severity of illness, patient stability, or weaning readiness. The instruments used were the Acute Physiology and Chronic Health Evaluation (APACHE III), the ... | null | 0.691 | 315 | Critical Care and Intensive Care Medicine | Medicine | 2,000 |
10,920,335 | Detection of fetal trisomy 18 by short-term culture of maternal peripheral blood. | American journal of obstetrics and gynecology | Am J Obstet Gynecol | 183 | 1 | 10.1067/mob.2000.105685 | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] We report the prenatal detection by fluorescence in situ hybridization analysis of a male fetus with trisomy 18. [STUDY DESIGN] Total nucleated cells recovered from 7 mL of maternal peripheral blood by means of double-density gradient centrifugation were cultured for 3 days in a devised medium. [RESULTS] Fe... | null | 1.624 | 274 | Obstetrics and Gynecology | Medicine | 2,000 |
10,919,940 | Retinol concentrations in capillary dried blood spots from healthy volunteers: method validation. | The American journal of clinical nutrition | Am J Clin Nutr | 72 | 2 | 10.1093/ajcn/72.2.450 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Vitamin A deficiency (VAD) is a major public health problem in the developing world, leading to >3 million eye-related problems in preschool children. Nearly 250 million children have subclinical VAD, resulting in a 23% increase in childhood mortality. Difficulties in obtaining samples to assess VAD have h... | null | 1.903 | 390 | Medicine; Nutrition and Dietetics | Medicine; Nursing | 2,000 |
10,919,887 | Criteria for nonsurgical management of subperiosteal abscess of the orbit: analysis of outcomes 1988-1998. | Ophthalmology | Ophthalmology | 107 | 8 | 10.1016/s0161-6420(00)00242-6 | eng | 2,000 | 8 | null | null | null | null | [PURPOSE] On the basis of bacteriologic studies, we have recommended expectant observation with intravenous antibiotics for subperiosteal abscess (SPA) of the orbit in patients less than 9 years of age, given the absence of eight other specific surgical criteria. We attempted to test these recommendations with a prospe... | null | 2.651 | 297 | Ophthalmology | Medicine | 2,000 |
10,916,109 | Influence of cold-storage conditions on renal function of autotransplanted large pig kidneys. | Kidney international | Kidney Int | 58 | 2 | 10.1046/j.1523-1755.2000.00233.x | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] The consequences of ischemia/reperfusion injury (IRI) on delayed graft function (DGF) and graft survival for kidney recipients remain a matter of debate. Several strategies have been proposed to reduce IRI. We have shown that adding the anti-ischemic drug trimetazidine (TMZ) to different preservation solut... | null | null | null | null | null | null |
10,914,909 | Absence of thyroid stunning after diagnostic whole-body scanning with 185 MBq 131I. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine | J Nucl Med | 41 | 7 | null | eng | 2,000 | 7 | null | null | null | null | [UNLABELLED] There has been recent controversy regarding the optimal protocol for imaging and ablation of post-thyroidectomy patients. Several authors have suggested that a scanning dose of 185-370 MBq (5-10 mCi) (131)I may be capable of producing a stunning effect on thyroid tissue that may interfere with the uptake a... | null | 1.485 | 247 | Medicine; Radiology, Nuclear Medicine and Imaging | Medicine | 2,000 |
10,914,866 | Joint hypermobility and primary fibromyalgia: a clinical enigma. | The Journal of rheumatology | J Rheumatol | 27 | 7 | null | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] To investigate the association of joint hypermobility (JH) and primary fibromyalgia (FM). [METHODS] Eighty-eight patients admitted with widespread pain and 90 matched healthy controls were blindly evaluated according to criteria for the presence of JH and FM. [RESULTS] Fifty-six patients initially recognize... | null | 1.162 | 201 | Immunology and Allergy; Rheumatology; Immunology | Immunology and Microbiology; Medicine | 2,000 |
10,914,844 | Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. | The Journal of rheumatology | J Rheumatol | 27 | 7 | null | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] To investigate estrogen receptor (ER) microsatellite allele frequencies in patients with rheumatoid arthritis (RA), and possible associations of ER microsatellites with osteoporosis and disease progression. [METHODS] We typed 144 Japanese females with RA and 200 healthy postmenopausal Japanese controls for ... | null | 1.162 | 201 | Immunology and Allergy; Rheumatology; Immunology | Immunology and Microbiology; Medicine | 2,000 |
10,912,700 | Electrocochleography and gentamicin therapy for Ménière's disease: a preliminary report. | The American journal of otology | Am J Otol | 21 | 4 | null | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVE] It is widely held that an enlarged summating potential (SP) relative to the eighth nerve action potential (AP) is a reflection of endolymphatic hydrops. Aminoglycosides are an accepted treatment for incapacitating Ménière's disease and are known to affect both sensory and secretory cells of the inner ear. T... | null | null | null | null | null | null |
10,912,695 | Degeneration in the cochlea after noise damage: primary versus secondary events. | The American journal of otology | Am J Otol | 21 | 4 | null | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] To determine if noise damage in the organ of Corti is different in the low- and high-frequency regions of the cochlea. [MATERIALS AND METHODS] Chinchillas were exposed for 2 to 432 days to a 0.5 (low-frequency) or 4 kHz (high-frequency) octave band of noise at 47 to 95 dB sound pressure level. Auditory thresh... | null | null | null | null | null | null |
10,912,690 | Preference for the closed technique in the management of cholesteatoma of the middle ear in children: a retrospective study of 215 consecutive patients treated over 10 years. | The American journal of otology | Am J Otol | 21 | 4 | null | eng | 2,000 | 7 | null | null | null | null | [OBJECTIVES] To evaluate clinical data, extensions, residual and recurrent lesion rates, and functional results in cases of cholesteatoma in pediatric patients. [DESIGN] A retrospective study at a single tertiary care center over a decade. [PATIENTS] In 199 children (mean age 9.6 years), 215 cholesteatomas were treated... | null | null | null | null | null | null |
10,912,664 | Chagasic megacolon and proximal jejunum microbiota. | Scandinavian journal of gastroenterology | Scand J Gastroenterol | 35 | 6 | 10.1080/003655200750023606 | eng | 2,000 | 6 | null | null | null | null | [BACKGROUND] Among other factors, control of jejunal microflora depends on intestinal emptiness, and it can be impaired by Chagas disease. This study was developed to identify the microecology of the proximal jejunum in chagasic megacolon. Our objective was to characterize both the jejunal microbial stasis before surge... | null | 0.934 | 133 | Gastroenterology | Medicine | 2,000 |
10,912,578 | Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats. | Cancer chemotherapy and pharmacology | Cancer Chemother Pharmacol | 46 | 1 | 10.1007/s002800000123 | eng | 2,000 | null | null | null | null | null | [PURPOSE] An important cytotoxic effect of 5-fluorouracil (5-FU) is the inactivation of thymidylate synthase (TS) (EC 2.1.1.45) activity by the formation of a ternary complex consisting of covalently bound 5-fluorodeoxyuridine 5'-monophosphate (FdUMP), TS and 5,10-methylenetetrahydrofolate (CH2FH4). The gastrointestina... | null | 0.699 | 127 | Pharmacology; Pharmacology; Cancer Research; Oncology; Toxicology | Biochemistry, Genetics and Molecular Biology; Medicine; Pharmacology, Toxicology and Pharmaceutics | 2,000 |
10,911,803 | Immunoflow cytometry and cell block immunohistochemistry in the FNA diagnosis of lymphoma: a review of 73 consecutive cases. | Journal of clinical pathology | J Clin Pathol | 53 | 6 | 10.1136/jcp.53.6.451 | eng | 2,000 | 6 | null | null | null | null | [AIMS] To review the results of 73 consecutive fine needle aspirations (FNAs) that were collected by a pathologist and analysed by immunoflow cytometry. Material for a cell block was also collected from some of these lesions. [METHODS] The setting was a large general hospital in rural New Zealand. The FNAs were perform... | null | 0.687 | 158 | Medicine; Pathology and Forensic Medicine | Medicine | 2,000 |
10,910,494 | Propofol selectively attenuates endothelium-dependent pulmonary vasodilation in chronically instrumented dogs. | Anesthesiology | Anesthesiology | 93 | 2 | 10.1097/00000542-200008000-00023 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] The objective was to investigate the effects of propofol anesthesia on the pulmonary vascular response to endothelium-dependent and -independent vasodilators, compared with the responses measured in the conscious state. [METHODS] Twenty-six conditioned, male, mongrel dogs were instrumented long-term to mea... | null | null | null | null | null | null |
10,910,446 | Dialysate related cytokine induction and response to recombinant human erythropoietin in haemodialysis patients. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | Nephrol Dial Transplant | 15 | 8 | 10.1093/ndt/15.8.1207 | eng | 2,000 | 8 | null | null | null | null | [BACKGROUND] Chronic inflammatory disorders or infections represent a major cause of hyporesponsiveness to recombinant human erythropoietin (rHuEpo). To test the hypothesis that dialysate-related cytokine induction alters the response to rHuEpo, we conducted a prospective study with matched pairs of chronic haemodialys... | null | 0.657 | 203 | Medicine; Nephrology; Transplantation | Medicine | 2,000 |
10,910,233 | Familial adenomatous polyposis: results after ileal pouch-anal anastomosis in teenagers. | Diseases of the colon and rectum | Dis Colon Rectum | 43 | 7 | 10.1007/BF02237346 | eng | 2,000 | 7 | null | null | null | null | [PURPOSE] Virtually all untreated patients with familial adenomatous polyposis develop colorectal carcinoma. Thus, prophylactic colectomy is indicated. Detractors of ileal pouch-anal anastomosis prefer ileorectal anastomosis for teenagers because of the potential negative impact of ileal pouch-anal anastomosis on quali... | null | 1.294 | 185 | Gastroenterology; Medicine | Medicine | 2,000 |
10,910,228 | High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer. | International journal of urology : official journal of the Japanese Urological Association | Int J Urol | 7 | 7 | 10.1046/j.1442-2042.2000.00187.x | eng | 2,000 | 7 | null | null | null | null | [BACKGROUND] The present study was performed in order to investigate the efficacy and safety of high-dose chemotherapy for the treatment of patients with advanced testicular cancer. [METHODS] Seven patients were treated with high-dose carboplatin, etoposide and cyclophosphamide followed by peripheral blood stem cell tr... | null | 0.513 | 83 | Urology | Medicine | 2,000 |
10,908,895 | A milestone for normal development of the infantile brain detected by functional MRI. | Neurology | Neurology | 55 | 2 | 10.1212/wnl.55.2.218 | eng | 2,000 | 7 | 25 | null | null | null | [OBJECTIVE] To investigate the relationship between cerebral cortical function and white matter myelination in the visual pathway in the evaluation of normal brain development. [METHODS] The authors performed quantitative analysis of white matter myelination detected with conventional T1-weighted spin echo (SE) MRI and... | null | 2.317 | 422 | Neurology | Medicine | 2,000 |
10,908,890 | Prevalence of AD among whites: a summary by levels of severity. | Neurology | Neurology | 55 | 2 | 10.1212/wnl.55.2.198 | eng | 2,000 | 7 | 25 | null | null | null | [OBJECTIVE] To determine age- and sex-specific AD prevalence rates for whites using each of four severity-based definitions of a case: a person diagnosed as having at least questionable AD, one diagnosed as having at least mild AD, one diagnosed as having moderate or severe AD, and one diagnosed as having severe AD. [M... | null | 2.317 | 422 | Neurology | Medicine | 2,000 |
10,908,255 | Endogenous endothelin maintains coronary artery tone by endothelin type A receptor stimulation in patients undergoing coronary arteriography. | Heart (British Cardiac Society) | Heart | 84 | 2 | 10.1136/heart.84.2.176 | eng | 2,000 | 8 | null | null | null | null | [OBJECTIVE] To examine the contribution of endothelin type A (ET(A)) receptor stimulation by endogenously generated endothelin-1 (ET-1) to the maintenance of coronary vascular tone in humans. [DESIGN] Controlled clinical study. [SETTING] Tertiary cardiovascular referral centre. [PATIENTS] 14 subjects were studied, seve... | null | 0.675 | 214 | Cardiology and Cardiovascular Medicine | Medicine | 2,000 |
10,908,220 | Cardioprotective mechanism of ischemic preconditioning is impaired by postinfarct ventricular remodeling through angiotensin II type 1 receptor activation. | Circulation | Circulation | 102 | 4 | 10.1161/01.cir.102.4.458 | eng | 2,000 | 7 | 25 | null | null | null | [BACKGROUND] Activation of protein kinase C-linked receptors and subsequent opening of the mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel are crucial in preconditioning (PC). This study examined whether postinfarct ventricular remodeling interferes with the PC mechanism. [METHODS AND RESULTS] Two weeks before is... | null | 5.669 | 691 | Cardiology and Cardiovascular Medicine; Physiology | Medicine | 2,000 |
10,908,017 | The disease burden of hepatitis B in Uzbekistan. | The Journal of infection | J Infect | 40 | 3 | 10.1053/jinf.1998.0666 | eng | 2,000 | 5 | null | null | null | null | [OBJECTIVE] To describe the burden of hepatitis B illness in Uzbekistan by means of model-based estimates. [METHODS] A mathematical simulation model was developed to mimic the disease evolution of hepatitis B and calculate the size and age of specific HBV patient groups, defined according to the severity of their illne... | null | 0.477 | 145 | Infectious Diseases; Microbiology | Medicine | 2,000 |
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