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This is a study to investigate whether applying the drug tranexamic acid (TXA) onto a surgical wound surface may affect the incidence of surgical complications such as re-bleeding needing intervention, wound complications such as infection, wound rupture or seroma, or if it may increase the risk of blood clots. |
Eligible patients: |
Patients undergoing plastic surgical procedures with wounds that would normally receive application of TXA to reduce bleeding after surgery. |
Study intervention: |
Participants will receive a single local application of study drug onto their wound surfaces at the end of surgery. Study drug will be identical looking ampoules which contain either TXA or placebo (saline). Neither participants nor study personnel will know the contents of the ampoules. conditions: Surgical Complicati... |
Randomization, blinding, labelling, shipment of ampoules and keeping of the randomization code will be done by Smerud Medical Research International AS. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 3000 type: ESTIMATED name: Tranexamic Acid 100 MG/ML name: ... |
<|newrecord|> nctId: NCT06270394 id: MJX briefTitle: FAP PET/CT or PET/MR Production in the Diagnosis, Staging, and Efficacy Assessment of Malignant Tumors Application overallStatus: SUSPENDED date: 2022-04-28 date: 2023-07-28 date: 2027-03-31 date: 2024-02-21 date: 2024-02-21 name: The First Affiliated Hospital of Anh... |
Fibroblast Activation Protein PET/CT(PET/MR) whether or in which cases this assay is superior to conventional FDG examination in the diagnosis, staging, and assessment of therapeutic efficacy of malignant tumors, thinking about the reasons behind this. |
Investigators will screen suitable participants among patients undergoing routine FDG examination. |
* Participants will sign an informed consent form |
* Undergo 68Ga-FAPI PET/CT (PET/MR) before surgery or biopsy |
* Surgical resection or puncture biopsy to obtain pathologic results. Diagnosis of patients with malignant tumors at first diagnosis; clinical staging of tumors; and clinical outcomes of patients with confirmed diagnoses will be assessed after postoperative investigator follow-up. |
The researchers will compare the FDG exams the participants have had to determine the effectiveness of the fibroblast activating protein test. conditions: Malignant Tumors conditions: Positron-Emission Tomography studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: DIAGNOS... |
<|newrecord|> nctId: NCT06270381 id: UIDB/05299/2020 briefTitle: Empower-Grief: A Study on a Selective Intervention to Prevent Prolonged Grief Disorder overallStatus: RECRUITING date: 2023-08-07 date: 2024-11-01 date: 2024-11-01 date: 2024-02-21 date: 2024-02-21 name: ISPA - Instituto Universitario de Ciencias Psicolog... |
<|newrecord|> nctId: NCT06270368 id: PREHMO briefTitle: Children Born Preterm: Sustainable Health Monitoring overallStatus: RECRUITING date: 2020-08-05 date: 2025-08-31 date: 2025-12-31 date: 2024-02-21 date: 2024-02-21 name: Meyer Children's Hospital IRCCS class: OTHER name: IRCCS Fondazione Stella Maris briefSummary:... |
<|newrecord|> nctId: NCT06270355 id: 2023-06555-01 briefTitle: Stockholm Mammography Risk Stratified Trial acronym: SMART overallStatus: NOT_YET_RECRUITING date: 2024-04-08 date: 2028-04-08 date: 2032-04-08 date: 2024-02-21 date: 2024-02-28 name: Karolinska Institutet class: OTHER briefSummary: SMART is a Phase III, ra... |
<|newrecord|> nctId: NCT06270342 id: DTMS briefTitle: The Effect of Dual Task On Upper Extremity Functions In Multiple Sclerosis Patients overallStatus: COMPLETED date: 2023-06-01 date: 2023-09-01 date: 2023-12-15 date: 2024-02-21 date: 2024-02-21 name: Kutahya Health Sciences University class: OTHER briefSummary: The ... |
<|newrecord|> nctId: NCT06270329 id: NMTwithKOA briefTitle: Neuromuscular Training Program in Patients With Knee OA (Osteoarthritis) acronym: OA overallStatus: COMPLETED date: 2022-01-15 date: 2023-01-15 date: 2023-06-15 date: 2024-02-21 date: 2024-02-21 name: Kutahya Health Sciences University class: OTHER briefSummar... |
<|newrecord|> nctId: NCT06270316 id: CT-AMT-191-01 briefTitle: Safety, PK/PD, and Exploratory Efficacy Study of AMT-191 in Classic Fabry Disease overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2027-04-01 date: 2027-04-29 date: 2024-02-21 date: 2024-02-21 name: UniQure Biopharma B.V. class: INDUSTRY briefSummar... |
<|newrecord|> nctId: NCT06270303 id: 2023-00383-01 briefTitle: Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2027-03-01 date: 2036-03-01 date: 2024-02-21 date: 2024-02-21 name: Göteborg University class: OTHER name: Johann Wolfgan... |
200 patients with ≥1 molar presenting with a furcation defect degree II will be included and randomized to either control (open-flap debridement) or test treatment (open-flap debridement + bone substitute material). The primary outcome of the study is furcation closure defined as absence of clinically detectable furcat... |
<|newrecord|> nctId: NCT06270290 id: 327648 briefTitle: The COSP-RBD Study: Concussions and Contact Sports in RBD vs Controls acronym: COSP-RBD overallStatus: RECRUITING date: 2024-04-22 date: 2025-03-30 date: 2025-03-30 date: 2024-02-21 date: 2024-04-23 name: Guy's and St Thomas' NHS Foundation Trust class: OTHER brie... |
The main questions it aims to answer are: |
* What is the proportion of patients with RBD that have a history of concussions or exposure to contact sports? |
* Is this proportion higher to that in control patients without a diagnosis of RBD? |
Participants will undergo an interview with a sleep medicine specialist to answer questions about history of concussions and contact sports practices. |
Researchers will compare an RBD group and a control group (without RBD) to see if the proportion of concussions and exposure to contact sports differ. conditions: REM Sleep Behavior Disorder conditions: Concussion, Brain studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: RETROSPECTIVE count: 140... |
<|newrecord|> nctId: NCT06270277 id: 30.01.2024-4272 briefTitle: Evaluation of Quality of Life and Psychosocial Status in Children With Inflammatory Bowel Disease overallStatus: COMPLETED date: 2024-02-14 date: 2024-02-20 date: 2024-02-21 date: 2024-02-21 date: 2024-02-22 name: Sisli Hamidiye Etfal Training and Researc... |
<|newrecord|> nctId: NCT06270264 id: 111-2023 briefTitle: Nociception Monitoring in Intensive Care overallStatus: COMPLETED date: 2023-08-01 date: 2023-12-15 date: 2024-01-01 date: 2024-02-21 date: 2024-02-21 name: Haseki Training and Research Hospital class: OTHER briefSummary: Precisely, pain in the ICU is a multidim... |
<|newrecord|> nctId: NCT06270251 id: PSYCH-2023-32292 briefTitle: Modeling Tic Change During Behavior Therapy for Tics overallStatus: RECRUITING date: 2024-03-01 date: 2028-03-01 date: 2028-09-01 date: 2024-02-21 date: 2024-04-01 name: University of Minnesota class: OTHER briefSummary: Chronic tics are a disabling neur... |
CBIT is a manualized treatment focused on increasing tic controllability. Its core procedure is competing response training (CRT), in which patients learn to inhibit tics by learning and applying a competing motor action to one tic at a time. CBIT is recommended as a first-line treatment relative to medications and oth... |
The overall objective of this study is to use fine-grained data collection strategies to identify patterns in tic controllability and other relevant related variables that are associated with treatment response to CBIT. Participants with chronic tics will complete a manualized course of 8-session CBIT. Behavioral, psyc... |
<|newrecord|> nctId: NCT06270238 id: 2023-11-164 briefTitle: Efficacy of Personalized Repetitive Transcranial Magnetic Stimulation Protocol Based on Functional Reserve to Enhance Upper Limb Function in Subacute Stroke Patients overallStatus: RECRUITING date: 2024-02-13 date: 2025-09-30 date: 2025-09-30 date: 2024-02-21... |
<|newrecord|> nctId: NCT06270225 id: SSGJ-613-PGF-II-01 briefTitle: A Study of SSGJ-613 in Gout Subjects Initiating Urate-Lowering Treatment. overallStatus: RECRUITING date: 2024-03-30 date: 2024-06 date: 2024-12 date: 2024-02-21 date: 2024-04-10 name: Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. class: INDUSTR... |
<|newrecord|> nctId: NCT06270212 id: CIV-ID 23-08-043797 briefTitle: Medical Device for Airway Patency During Sedation acronym: STAIRWAY-2 overallStatus: RECRUITING date: 2024-02-01 date: 2024-06-30 date: 2024-12-31 date: 2024-02-21 date: 2024-02-21 name: Stairway Medical AB class: INDUSTRY name: Lund University briefS... |
PART A: Systematic evaluation in spontaneously breathing healthy volunteer study participants |
* of cumulative duration of manual measures for airway patency and for mask ventilation with airway device prototype (STAIRWAY) vs. standard procedure (no device) during target-controlled induction of mild and moderate-to-deep sedation with propofol in the supine position |
* of minimum anteroposterior and lateral transpharyngeal distances at tongue-base and soft-palate levels, determined by magnetic resonance imaging (MRI) with STAIRWAY vs. biteblock or no device during no, mild and moderate-to-deep steady-state sedation with propofol in the supine position. |
PART B: Systematic evaluation (in the body position \[normally supine\] considered most optimal for the procedural intervention) of the cumulative duration |
* of adjuvant manual airway support and ventilation |
* of respiratory arrest (interrupted monitoring of endtidal carbon dioxide \[ETCO2\]) |
* of hypoxemia (hemoglobin saturation of oxygen \[SpO2\] \<95 %), and |
* of perceived sedational comfort, of sedational and procedural usability, and of sedational and procedural preference with STAIRWAY vs. standard procedure (biteblock or no device) during PS according to SOC for scheduled diagnostic or therapeutic procedures planned to be carried out under PS with propofol in spontaneo... |
The number of arms reported below (3) refers to unpaired comparisons (PARTS A-B). primaryPurpose: PREVENTION masking: SINGLE maskingDescription: For practical reasons, study participants, sedationists and study investigators on site cannot be masked to study interventions. |
However, procedural interventionists on site and study investigators scrutinizing study outcome data will be masked to study interventions. |
The number of enrolled study participants reported below (46) refers to evaluable ones. whoMasked: OUTCOMES_ASSESSOR count: 46 type: ESTIMATED name: STAIRWAY name: NO DEVICE measure: Transpharyngeal distance during moderate-to-deep steady-state sedation. measure: Duration of manual airway support during PS for clinical... |
<|newrecord|> nctId: NCT06270199 id: PULMESCELL-2 briefTitle: Use of Mesenchymal Stem Cells in Pre-term Patients With Bronchopulmonary Dysplasia. overallStatus: RECRUITING date: 2024-01-11 date: 2025-12 date: 2026-12 date: 2024-02-21 date: 2024-02-21 name: Fundacion para la Investigacion Biomedica del Hospital Universi... |
<|newrecord|> nctId: NCT06270186 id: 20-AOIP-04 briefTitle: Evaluation of Cognitive Functions in 20 Patients With Type 1 Myotonic Dystrophy With Virtual Reality Approach acronym: GoodDiagNMD overallStatus: WITHDRAWN date: 2023-11 date: 2024-11 date: 2024-11 date: 2024-02-21 date: 2024-02-21 name: Centre Hospitalier Uni... |
Currently, the cognitive assessment of MD1 patients is based on classical neuropsychological tests, which are time-consuming and require a MD1 expert neuropsychologist. Moreover, it is usually very difficult for MD1 patients to accept performing these tests, and when they agree to perform them, they usually give up bef... |
In order to overcome these difficulties in assessing cognitive functions of MD1 patients, the investigators decided to use innovative tools such as virtual reality, which allow individuals to experience a sensory-motor and cognitive experience in a digitally world through a helmet, glasses and joysticks. |
The start-up My Cyber Royaume from Lille, in collaboration with the reference center of neuromuscular diseases from Nice coordinated by Pr Sacconi, have developed a software "Good Diag NMD" which uses virtual reality to assess cognitive disorders, more specifically executive functions in patients with type 1 myotonic d... |
<|newrecord|> nctId: NCT06270173 id: TWM-C-2202 briefTitle: Post-Market Study of The Tripod-Fix Vertebral Body Augmentation System in Osteoporotic Vertebral Compression Fractures overallStatus: RECRUITING date: 2024-02-16 date: 2025-07-31 date: 2025-12-31 date: 2024-02-21 date: 2024-02-21 name: Wiltrom Co., Ltd. class:... |
<|newrecord|> nctId: NCT06270160 id: KampalaLivelihoodsStudy briefTitle: Livelihoods Intervention With Urban Refugee Youth in Kampala, Uganda overallStatus: RECRUITING date: 2024-03-01 date: 2024-08-01 date: 2024-12-31 date: 2024-02-21 date: 2024-03-01 name: University of Toronto class: OTHER briefSummary: Displaced an... |
Since there is a dearth of knowledge regarding efficacious interventions in refugee camps/settlements to engage young people in HIV testing and linkage to care, the investigators will harness various health promotion techniques including mHealth, comics, and the Creating Futures livelihoods intervention to address the ... |
<|newrecord|> nctId: NCT06270147 id: 16935 briefTitle: Timing of TAP Blocks in Bariatric Surgery overallStatus: NOT_YET_RECRUITING date: 2024-03-04 date: 2024-06-28 date: 2024-06-28 date: 2024-02-21 date: 2024-02-21 name: McMaster University class: OTHER briefSummary: This clinical trial aims to determine the optimal t... |
<|newrecord|> nctId: NCT06270134 id: 14410 briefTitle: Dial-Bicarb Trial: Effects of a Lower vs. Higher Concentration of Dialysate Bicarbonate overallStatus: NOT_YET_RECRUITING date: 2025-01 date: 2029-01 date: 2029-01 date: 2024-02-21 date: 2024-02-21 name: McMaster University class: OTHER name: Canadian Institutes of... |
<|newrecord|> nctId: NCT06270121 id: R2111483 briefTitle: Development of a Healthcare Service Platform for Successful Aging overallStatus: RECRUITING date: 2020-10-21 date: 2026-11-30 date: 2030-11-30 date: 2024-02-21 date: 2024-02-21 name: Sunmi Song class: OTHER briefSummary: The goal of this living-lab clinical tria... |
* Identify digital sensing variables that are predictive of mental and physical health declines and health emergencies of older adults |
* Develop digital health monitoring service to inform individualized daily health status of older adults users |
* Develop ICT network to share the daily health status and emergency signals with community based healthcare service providers and family caregivers if an older adult user approves of them to receive their health information. |
Participants will be asked to participate in a living lab using a wearable sensor, motion sensor, and smartphone applications for 6 weeks and also take part in pre-mid-post surveys to evaluate the usability, accuracy, and effectiveness of the digital healthcare service platform to improve health managements and connect... |
If there is a comparison group: Researchers will compare age and gender matched control group to see if health status of the living-lab group is better than the control group. conditions: Depression in Old Age conditions: Chronic Pain conditions: Sleep Disorder Insomnia Chronic studyType: INTERVENTIONAL phases: NA allo... |
<|newrecord|> nctId: NCT06270108 id: 22/SS/0040 id: 299382 type: OTHER domain: Integrated Research Application System briefTitle: The Role of Glutamatergic Function in the Pathophysiology of Treatment-resistant Schizophrenia acronym: RESTORE overallStatus: RECRUITING date: 2022-11-14 date: 2024-12-31 date: 2024-12-31 d... |
To assess the role of glutamate in treatment-resistant schizophrenia using magnetic resonance spectroscopy. |
To assess the relationship between glutamate levels and brain structural and functional measures (using: structural MRI; functional MRI (fMRI) and arterial spin labelling (ASL)) at baseline. |
To assess the relationship between longitudinal change in glutamate levels and brain structural and functional measures. |
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