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* Do children with GI issues show an altered lung microbiome? |
Part B is a longitudinal study design, that aims to assess the effects of biologics on the gut-lung axis by comparing the gut and lung microbiomes in children with asthma at two time-points who are indicated to start biologics therapy (Asthma treatment) or will not receive biologics therapy (asthma control). |
Participants will provide: |
* airway samples (to investigate the lung microbiome) |
* blood samples (to assess inflammatory and metabolic factors which may mediate communication between the two sites) whilst under general anaesthetic for a treatment related to their standard of care |
* stool samples (to assess gut microbiome) |
* dietary information (food diary and/or food frequency questionnaire) to assess relationships between diet and the gut-lung axis. conditions: Respiration Disorders conditions: Respiratory Disease conditions: Asthma in Children conditions: Wheezing conditions: Gastro-Intestinal Disorder conditions: Healthy studyType: O... |
<|newrecord|> nctId: NCT06271200 id: MG-113-GP-03 briefTitle: Intervention on Metabolism and Related Chronic Diseases overallStatus: NOT_YET_RECRUITING date: 2024-02-20 date: 2026-01-19 date: 2027-12-31 date: 2024-02-21 date: 2024-02-21 name: National Health Research Institutes, Taiwan class: OTHER name: Tri-Service Ge... |
<|newrecord|> nctId: NCT06271187 id: A-ER-110-507 briefTitle: Dynamic-orthosis Programs for Stroke Hand Function overallStatus: RECRUITING date: 2023-01-22 date: 2024-10-31 date: 2024-12-31 date: 2024-02-21 date: 2024-02-21 name: National Cheng-Kung University Hospital class: OTHER briefSummary: This study aims to inve... |
<|newrecord|> nctId: NCT06271174 id: RC23_0009 briefTitle: Avoid With Locoregional Analgesia Persistant Postoperative Pain In Children acronym: AWA3PASIC overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-05 date: 2026-05 date: 2024-02-21 date: 2024-04-09 name: Nantes University Hospital class: OTHER name: Fond... |
Persistent postoperative pain can be a problem even in ambulatory surgery. Loco-regional analgesia could prevent the occurrence of this pathology but contradictory results are found in ancient studies. |
This study is the first randomized controlled study in children about loco-regional analgesia and persistent postoperative pain in traumatologic orthopedic surgery. |
One interventional arm will receive a locoregional analgesia after general anesthesia and before incision. The other arm will only receive systemic analgesia during general anesthesia. |
The incidence of persistent postoperative pain at 3, 6 and 12 months will be compared in these two groups. |
The goal is to show the decrease of the incidence of the persistent postoperative pain in the group "locoregional analgesia". conditions: Persistent Postoperative Pain studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 208 type: EST... |
<|newrecord|> nctId: NCT06271161 id: F002 briefTitle: The Effect of Pharyngeal Cooling Applications on Postoperative Throat Pain and Nausea Vomiting overallStatus: COMPLETED date: 2023-01-01 date: 2023-11-01 date: 2024-01-01 date: 2024-02-21 date: 2024-02-21 name: Selcuk University class: OTHER briefSummary: The goal o... |
<|newrecord|> nctId: NCT06271148 id: Mutah University id: Myah REC/133/2023 type: REGISTRY domain: Mutah university school of medicine briefTitle: Career and Lifestyle Among Female Surgeons in Jordan overallStatus: COMPLETED date: 2023-02-03 date: 2023-12-17 date: 2023-12-31 date: 2024-02-21 date: 2024-02-21 name: Moha... |
<|newrecord|> nctId: NCT06271135 id: LU20170508 briefTitle: Assessing the Quality of Life of Patients With Rosacea overallStatus: COMPLETED date: 2017-05-08 date: 2018-11-30 date: 2018-11-30 date: 2024-02-21 date: 2024-02-21 name: Medical University of Bialystok class: OTHER name: University of Lomza briefSummary: The ... |
<|newrecord|> nctId: NCT06271122 id: COMPET-1 briefTitle: Identification of Explanatory Factors for the Lack of Muscle Strength Gain Following a Pulmonary Rehabilitation Program in COPD Patients overallStatus: RECRUITING date: 2024-01-18 date: 2025-05-16 date: 2025-05-16 date: 2024-02-21 date: 2024-02-21 name: Korian c... |
The investigators hypothesize that patients showing no improvement in muscle strength after pulmonary rehabilitation (non-responders) have a significantly lower level of voluntary activation before starting the program compared to responding patients (responders). conditions: Chronic Obstructive Pulmonary Disease study... |
<|newrecord|> nctId: NCT06271109 id: Soh-Med-24-01-04MD briefTitle: Short Term Surgical Outcomes of Anatomical Versus Non Anatomical Laparoscopic Liver Resection for Liver Tumors overallStatus: ENROLLING_BY_INVITATION date: 2021-12-01 date: 2025-06-01 date: 2025-06-01 date: 2024-02-21 date: 2024-02-21 name: Sohag Unive... |
<|newrecord|> nctId: NCT06271096 id: 638/ADR/KMC briefTitle: Intramuscular Midazolam Versus Intravenous Diazepam for Acute Seizure in Children overallStatus: COMPLETED date: 2019-11-01 date: 2022-11-01 date: 2024-01-01 date: 2024-02-21 date: 2024-02-23 name: Arooj Khan class: OTHER briefSummary: IM-midazolam in acute s... |
<|newrecord|> nctId: NCT06271083 id: 2023-06541-01 briefTitle: Internet-based Behavior Therapy for Adults With Tourette Syndrome acronym: TICNET overallStatus: RECRUITING date: 2024-02-02 date: 2026-05 date: 2028-05 date: 2024-02-21 date: 2024-02-21 name: Karolinska Institutet class: OTHER briefSummary: This study prot... |
<|newrecord|> nctId: NCT06271070 id: 2023-R23 briefTitle: Analysis of Correlation Between Skin Carotenoid Level and Basic Indicators of Health Status Related to Lifestyle in Vietnamese: An Observational Study overallStatus: RECRUITING date: 2024-01-16 date: 2024-05-31 date: 2024-12-31 date: 2024-02-21 date: 2024-02-21 ... |
<|newrecord|> nctId: NCT06271057 id: CARMOD briefTitle: Golcadomide Post-CAR T-cell in R/R Aggressive Large B-cell Lymphoma Patients With High Risk of Relapse overallStatus: NOT_YET_RECRUITING date: 2024-04-22 date: 2026-01-15 date: 2027-10-20 date: 2024-02-21 date: 2024-02-21 name: The Lymphoma Academic Research Organ... |
Approximatively 65 patients with aggressive large B-cell lymphoma (LBCL) (including diffuse large B-cell lymphoma (DLBCL), Primary mediastinal B-cell lymphoma (PMBCL), any transformed follicular or marginal zone lymphoma, high-grade B-cell lymphoma (HGBL)) will be enrolled in the study. |
The duration of treatment with golcadomide (CELMoD) is 24 weeks with 6 cycles of 28 days (4 weeks), starting at 5 days after CAR-T cells infusion. |
The primary objective of the study is to estimate the efficacy of golcadomide administered post-anti-CD19 CAR T-cell infusion, Efficacy determination will be based upon the primary endpoint of complete metabolic response (CMR) rate at 3 months after infusion of anti-CD19 CAR T-cell assessed by study investigator. condi... |
<|newrecord|> nctId: NCT06271044 id: RAILESS briefTitle: a. Reducing Radioiodine Treatment in Papillary Thyroid Cancer. RAILESS overallStatus: ACTIVE_NOT_RECRUITING date: 2014-10 date: 2024-12 date: 2027-12-31 date: 2024-02-21 date: 2024-02-21 name: Helsinki University Central Hospital class: OTHER briefSummary: To stu... |
<|newrecord|> nctId: NCT06271031 id: LHS0211 briefTitle: Process Mapping and Data Collection to Inform a Computer Simulation Model of Hospitalised Patients With Bloodstream Infection, Sepsis and Systemic Infection acronym: CSM-BSI overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-12-31 date: 2026-03-31 date... |
* Interviews with healthcare staff to understand patient care pathways. |
* Analysis of historical data on bacteria causing infections and antibiotic treatments. |
* A 30-day observational study to observe patient treatment for bloodstream infections. conditions: Sepsis conditions: Bloodstream Infection conditions: Bacteraemia studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: RETROSPECTIVE count: 100 type: ESTIMATED measure: Generation of a software simulation m... |
<|newrecord|> nctId: NCT06271018 id: GMIO-2024-0001 briefTitle: TocILizumab in aorTitis in GCA (TILT) acronym: TILT overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-10-01 date: 2028-04-01 date: 2024-02-21 date: 2024-02-21 name: GMIOFrance class: UNKNOWN briefSummary: This is a french multicenter observatio... |
Giant Cell Arteritis (GCA), formerly known as temporal arteritis, is the most common form of systemic vasculitis in patients aged ≥ 50 years. GCA is defined by granulomatous arteritis that affects large#sized and medium#sized blood vessels with a predisposition to affect the cranial arteries. Aortitis accounted for mor... |
Multiple reports have demonstrated the presence of abnormal pro-inflammatory cytokine production in large-vessel vasculitis patients, particularly those with GCA, including interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-α (TNF-α), and interferon-γ, by T lymphocytes and macrophages. IL-6 has been implicated as... |
The GIACTA study (GiAnt cell arteritis roActemra (tocilizumab) study) was a randomized, double-blind, placebo-controlled trial that evaluated the efficacy and safety of tocilizumab in the treatment of GCA. The study included 251 patients with newly diagnosed or relapsing GCA and found that treatment with tocilizumab si... |
Following the positive results of the GIACTA study, tocilizumab was approved for the treatment of GCA in adults with active disease, including aortitis, who have not responded to glucocorticoids, or for whom glucocorticoid therapy is not appropriate, by regulatory agencies around the world, including the US Food and Dr... |
However, the efficacy of IL-6 inhibitors on aorta inflammation as assessed by modern and powerful imaging techniques has never been specifically studied in GCA. |
This observational study will provide important informations on the impact of Tyenne® (tocilizumab) associated with short term low dose steroids on clinical manifestations and vessel inflammation and damage in aortitis of GCA. conditions: Giant Cell Arteritis conditions: Aortitis studyType: OBSERVATIONAL observationalM... |
<|newrecord|> nctId: NCT06271005 id: 000824 briefTitle: Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2024-10-01 date: 2024-02-21 date: 2024-02-21 name: Genetic Disease Investigators class: OTHER briefSummary: This is a st... |
<|newrecord|> nctId: NCT06270992 id: 123R030 briefTitle: Oral Microbiome Diagnostics of Lung Cancer overallStatus: RECRUITING date: 2023-11-15 date: 2025-02-15 date: 2026-05-15 date: 2024-02-21 date: 2024-02-21 name: TC Erciyes University class: OTHER name: THE SCIENTIFIC AND TECHNOLOGICAL RESEARCH COUNCIL OF TÜRKİYE b... |
<|newrecord|> nctId: NCT06270979 id: ISHA briefTitle: Intrinsic Capacity and Functional Ability Monitoring With an Integrated Data Eco-System for Healthy Ageing. acronym: ISHA overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-04-01 date: 2024-02-21 date: 2024-02-21 name: Prof. Ivan Bautmans... |
The aims of the study are: |
1. to evaluate the usability and feasibility of self-monitoring intrinsic capacity by using the ISHA system in rehabilitation and nursing home settings. |
2. to investigate if changes and variability in intrinsic capacity as measured with ISHA are related to changes in functional ability and quality of life. |
3. to explore individual trajectories of intrinsic capacity with the ISHA system. conditions: Frailty studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_SECTIONAL count: 120 type: ESTIMATED name: ISHA measure: Potential technical problems of the ISHA system measure: Potential technical problems ... |
<|newrecord|> nctId: NCT06270966 id: 28287 08/11/2023 briefTitle: Cognitive Remediation VR Tool for People With MCI: a Feasibility RCT overallStatus: NOT_YET_RECRUITING date: 2024-03-07 date: 2024-12-01 date: 2025-12-01 date: 2024-02-21 date: 2024-02-21 name: University of Cagliari class: OTHER briefSummary: The need t... |
<|newrecord|> nctId: NCT06270953 id: DZ_NX_US briefTitle: Non-invasive Monitoring: Impact on Patient Management and Outcomes overallStatus: RECRUITING date: 2024-01-19 date: 2024-03-30 date: 2024-06-30 date: 2024-02-21 date: 2024-02-28 name: Turtle Shell Technologies Pvt. Ltd. class: INDUSTRY briefSummary: Enhancing pa... |
<|newrecord|> nctId: NCT06270940 id: 2023.0922 briefTitle: Pulsed Radiofrequency Therapy on Peripheral Nerves Monitoring Pain, Quality of Life, Patient Satisfaction and Efficacy acronym: PURPOSE overallStatus: RECRUITING date: 2024-03-04 date: 2025-10-31 date: 2026-02-28 date: 2024-02-21 date: 2024-04-24 name: Amsterda... |
<|newrecord|> nctId: NCT06270927 id: 00003830 briefTitle: A Feasibility Study for Randomization of Code Stroke Imaging Strategies acronym: CSI overallStatus: RECRUITING date: 2023-10-23 date: 2024-03-30 date: 2024-07-10 date: 2024-02-21 date: 2024-02-21 name: University of Texas at Austin class: OTHER name: Lone Star S... |
<|newrecord|> nctId: NCT06270914 id: IBIS briefTitle: Inclusive Positive Behaviour Supports acronym: IBIS overallStatus: RECRUITING date: 2023-08-25 date: 2025-09-30 date: 2025-12-31 date: 2024-02-21 date: 2024-02-21 name: Uppsala University class: OTHER name: The Swedish Research Council briefSummary: Background: Whil... |
<|newrecord|> nctId: NCT06270901 id: BMEL: 2822EPS008 briefTitle: Acute Effects of Legume-enriched Meals Compared to Western Diet Meals on Postprandial Metabolism in Participants With Increased Cardiometabolic Risk acronym: LeguPlan_1 overallStatus: RECRUITING date: 2024-05-01 date: 2024-07-30 date: 2024-07-30 date: 20... |
<|newrecord|> nctId: NCT06270888 id: IRB23-1011 briefTitle: Hypofractionation (Radiation) Trial for Multiple Myeloma overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-05-01 date: 2028-05-01 date: 2024-02-21 date: 2024-02-21 name: University of Chicago class: OTHER briefSummary: This study if for people who ... |
<|newrecord|> nctId: NCT06270875 id: PROJECT ADAPT-HF briefTitle: Addressing Pain Through Navigator-Led Palliative Care Optimized for Heart Failure (ADAPT-HF) acronym: ADAPT HF overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-03 date: 2025-01-03 date: 2024-02-21 date: 2024-03-07 name: University of Alab... |
<|newrecord|> nctId: NCT06270862 id: SSHRC-PEG2023-AAT briefTitle: A Digital Active Aging Training Program for Older Adults acronym: AAT overallStatus: RECRUITING date: 2024-04-08 date: 2024-10-30 date: 2024-12-31 date: 2024-02-21 date: 2024-04-10 name: Toronto Metropolitan University class: OTHER name: Social Sciences... |
The proposed study takes a typical pretest-training-posttest design. Pretest and posttest: a battery of outcome measures on physical, psychological, and social functions will be administered to all participants. Data will also be used to identify sociodemographic risk predictors for outcome variables (i.e., biopsychoso... |
In the "active aging with resilience (AR)" condition, participants will complete physical, cognitive, and social engagement training modules, starting with a 30-min resilience-building module. The traditional "active aging" (AA) training involves the same multi-domain active aging training without the initial resilienc... |
<|newrecord|> nctId: NCT06270849 id: MTU-EC-SU-0-002/66 briefTitle: Validity and Reliability of ICIQ-FLUTS LF in Thai Version and Correlation With IPSS overallStatus: COMPLETED date: 2023-02-24 date: 2023-12-31 date: 2024-01-20 date: 2024-02-21 date: 2024-02-21 name: Thammasat University Hospital class: OTHER briefSumm... |
<|newrecord|> nctId: NCT06270836 id: KS301P108 briefTitle: A Study to Evaluate the Efficacy and Safety of Tarcocimab Tedromer Compared With Sham Treatment in Participants With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy (NPDR) acronym: GLOW2 overallStatus: RECRUITING date: 2024-03-27 date: 2025-1... |
<|newrecord|> nctId: NCT06270823 id: NIMR/HQ/R.8a/Vol.IX/4331 briefTitle: Reducing Respiratory Distress After Elective Caesarean Birth Through Knee-chest-flexion: a Randomized Controlled Trial overallStatus: RECRUITING date: 2024-02-14 date: 2025-02-14 date: 2025-02-14 date: 2024-02-21 date: 2024-02-21 name: Kilimanjar... |
The goal of this clinical trial is to test whether performing a knee-to-chest flexion maneuver directly after elective caesarean section will decrease the incidence of respiratory distress in term infants when compared to the standard care conditions: Transient Tachypnea of the Newborn studyType: INTERVENTIONAL phases:... |
<|newrecord|> nctId: NCT06270810 id: Aero-PA briefTitle: Cardiometabolic Effects of Combined Aerobic Exercise and Non-Exercise Physical Activity overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-11 date: 2025-03-18 date: 2025-06-01 date: 2024-02-21 date: 2024-03-15 name: Kastamonu University class: OTHER briefSummary:... |
The main question it aims to answer is: |
• Do both increasing non-exercise physical activity and doing aerobic exercise add more beneficial cardiometabolic effects to performing aerobic exercise alone in overweight young women? |
To answer this question, overweight young women will be randomly assigned to two different groups of this research. Volunteers in one of the groups will do moderate-intensity aerobic training and the other group will increase their non-exercise physical activities in addition to moderate-intensity aerobic training. The... |
<|newrecord|> nctId: NCT06270797 id: KMUHIRB-E(I)-20230184 briefTitle: Pre-anesthesia Imaging-based Respiratory Assessment and Analysis overallStatus: RECRUITING date: 2024-03-01 date: 2026-12-31 date: 2026-12-31 date: 2024-02-21 date: 2024-02-21 name: Kaohsiung Medical University Chung-Ho Memorial Hospital class: OTHE... |
<|newrecord|> nctId: NCT06270784 id: 09.2024.122 briefTitle: Traditional vs Orthodontic Extraction of Impacted Teeth Related to the Inferior Alveolar Nerve overallStatus: RECRUITING date: 2024-01-17 date: 2024-07-17 date: 2024-09-17 date: 2024-02-21 date: 2024-02-21 name: Marmara University class: OTHER briefSummary: T... |
-Does the orthodontic extraction method reduce the risk of nerve injury compared to traditional extraction? |
Participants will: |
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