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To assess the relationship between longitudinal change in glutamate levels and changes in psychopathology. |
The researchers will compare the changes with healthy controls and those without treatment-resistant schizophrenia. conditions: Treatment-resistant Schizophrenia conditions: Treatment-responsive Schizophrenia conditions: Healthy Controls studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: NON_RANDOMIZED interven... |
<|newrecord|> nctId: NCT06270095 id: C21-57 briefTitle: " Fume Events in Air Flights: Consequences on Cabin Air Quality and on Aircrews Health of a French Fleet of Aircraft" acronym: AVISAN overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-04 date: 2025-04 date: 2024-02-21 date: 2024-02-21 name: Institut Natio... |
<|newrecord|> nctId: NCT06270082 id: IK595-001 briefTitle: Study of IK-595 in RAS- or RAF-altered Advanced Tumors overallStatus: RECRUITING date: 2023-12-18 date: 2027-07 date: 2027-07 date: 2024-02-21 date: 2024-03-12 name: Ikena Oncology class: INDUSTRY briefSummary: This is a Phase 1, FIH, Dose Escalation and Dose E... |
<|newrecord|> nctId: NCT06270069 id: 2024-001 briefTitle: Responsiveness and Minimal Important Change of Two Measures of Pain Intensity in People With Low Back Pain overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-02-28 date: 2025-02-28 date: 2024-02-21 date: 2024-02-21 name: International Institute of Beh... |
<|newrecord|> nctId: NCT06270056 id: 1058 briefTitle: Evaluation of Telemedicine Medical Abortion Service in Ecuador overallStatus: NOT_YET_RECRUITING date: 2024-02 date: 2025-02 date: 2025-02 date: 2024-02-21 date: 2024-02-21 name: Gynuity Health Projects class: OTHER briefSummary: This research seeks to demonstrate t... |
<|newrecord|> nctId: NCT06270043 id: 809622 briefTitle: Focal Therapy for Localized Prostate Cancer overallStatus: RECRUITING date: 2024-02-01 date: 2034-02-01 date: 2034-02-01 date: 2024-02-21 date: 2024-02-26 name: University of California, San Diego class: OTHER briefSummary: This prospective registry and longitudin... |
<|newrecord|> nctId: NCT06270030 id: JX07002 id: CTR20240460 type: OTHER domain: China Center for Drug Evaluation (CDE), NMPA briefTitle: Safety, Tolerability and Pharmacokinetics of LNZ101 and LNZ100 Ophthalmic Solutions in Healthy Adult Chinese With Presbyopia overallStatus: COMPLETED date: 2024-03-04 date: 2024-04-1... |
<|newrecord|> nctId: NCT06270017 id: 282242 briefTitle: Evaluation of Metastatic Disease and Oncological Treatment in Patients With Colon Cancer Using Zebra Fish Avatars acronym: ZEBRA-COLON overallStatus: RECRUITING date: 2022-01-10 date: 2025-12-31 date: 2028-12-31 date: 2024-02-21 date: 2024-02-21 name: University H... |
2.2 Objective: The objective of this project is to explore the usefulness of zebrafish (Danio Rerio) embryo models to determine tumor biology and treatment response in colon cancer. An overarching goal would be, before start of any oncological treatment in a patient, to have evaluated the response of oncological treatm... |
2.3 Study design: This protocol describes a series of prospective studies in different cohorts of patients with colon cancer to investigate the applicability of zebrafish embryo models. The common denominator of the sub-studies is prospective collection of tumor tissue implanted in zebrafish embryos in order to evaluat... |
2.4 Intervention: In all sub-studies the intervention is inoculation of tumor cells in zebrafish embryos followed by observation of tumor behavior and testing of treatments. conditions: Colon Cancer studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP interventionModelD... |
<|newrecord|> nctId: NCT06270004 id: nonsurgical periodontal briefTitle: Effect of Nonsurgical Periodontal Therapy on Salivary Biomarkers Related to Bone Turnover in Smoker and Nonsmoker Periodontitis Patients overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-11-01 date: 2024-12-01 date: 2024-02-21 date: 20... |
2. To evaluate the response of clinical periodontal parameters ( plaque index ,bleeding on probing ,probing pocket depth ,clinical attachment loss)following NSPT in smoker and nonsmoker unstable periodontitis patients at different time intervals (one month and three months) conditions: Non Surgical Periodontal Therapy ... |
<|newrecord|> nctId: NCT06269991 id: SBA23/083 briefTitle: Fascial Anthropometry in Archery Athletes overallStatus: NOT_YET_RECRUITING date: 2024-02-15 date: 2024-09-06 date: 2025-09-06 date: 2024-02-21 date: 2024-02-21 name: Hacettepe University class: OTHER briefSummary: In archery, the body morphological and anthrop... |
<|newrecord|> nctId: NCT06269978 id: OSU-23195 id: NCI-2023-10497 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: R21CA282536 type: NIH link: https://reporter.nih.gov/quickSearch/R21CA282536 briefTitle: Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metasta... |
<|newrecord|> nctId: NCT06269965 id: 2023-A02181-44 briefTitle: Assessment of Collagen Membrane Interest in Distal Cuff Lesions Repair acronym: REGENECUFF overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2027-04-15 date: 2027-04-15 date: 2024-02-21 date: 2024-02-29 name: GCS Ramsay Santé pour l'Enseignement et ... |
Rotator cuff surgery is an increasingly popular procedure practiced in France. In limited cuff lesions (distal or intermediates) and in absence of contraindication, absence of tendons' healing is around 10 to 20%. Sofcot estimates that 90% of caps' heals remain healed 10 years after surgery in distal lesions. However, ... |
Bioinductive implant Regeneten® is an advanced healing solution for biological improvement and regeneration of tendons on all types rotator cuff tear. A randomized study was initiated whose main objective was to evaluate integrity of repaired tendon with MRI one year after intervention according to Sugaya's classificat... |
In this context, this study is based on hypothesis that adding Regeneten® during rotator cuff repair could be beneficial on tendon healing rate but also on tendon quality healing. conditions: Cuff Rotator Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TR... |
<|newrecord|> nctId: NCT06269952 id: MVarmafalk briefTitle: Intimate Partner Violence Among People Who Inject Drugs - Prevalence, Risk Factors and Experiences overallStatus: RECRUITING date: 2023-10-05 date: 2025-03 date: 2028-12 date: 2024-02-21 date: 2024-02-21 name: Region Stockholm class: OTHER_GOV briefSummary: Th... |
In Sweden, harm reduction units such as needle and syringe programs (NSP) have scaled-up in recent years. In Stockholm the first NSP opened in 2013 and the second in 2018. In 2022, 4600 individuals were enrolled in the program since it opened, of which approximately 25% were women. Around 2000 were active participants,... |
Gender-based violence (GBV) is a global health issue and WHO estimates that one in three women globally have been exposed to some sort of partner violence during their lifespan (7). Intimate partner violence (IPV) is defined as violent behavior between two people who have a close relationship, such as partners, ex-part... |
PWID and specifically WWID are regarded as groups who are especially vulnerable for IPV exposure and should therefore be prioritized in the national efforts to prevent IPV (15). However, there are no studies estimating the prevalence and frequency of IPV among PWID in Sweden. Previous international studies suggest that... |
The overall aim of this project is to increase knowledge about IPV among PWID and WWID as particularly vulnerable groups in regards to IPV. More specifically, the aim is to investigate the prevalence and frequency of different types of IPV among PWID at the Stockholm NSP and to explore the experiences' of IPV, needs an... |
<|newrecord|> nctId: NCT06269939 id: R-1253-24 briefTitle: Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-03-30 date: 2025-03-30 date: 2024-02-21 date: 2024-02-21 name: Kessler Foundation class: OTHER briefSum... |
<|newrecord|> nctId: NCT06269926 id: IRB00431182 briefTitle: Cognitive Behavioral Therapy for Chronic Pain in Adults With Cerebral Palsy overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-04 date: 2025-04 date: 2024-02-21 date: 2024-02-23 name: Hugo W. Moser Research Institute at Kennedy Krieger, Inc. class: OT... |
<|newrecord|> nctId: NCT06269913 id: 23-0826 briefTitle: A Novel Iron-Based Supplement for Athletes Aged 18-25: Phase II overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-09 date: 2024-12 date: 2024-02-21 date: 2024-03-26 name: University of Calgary class: OTHER name: Mitacs name: Natural Sciences and Engineer... |
<|newrecord|> nctId: NCT06269900 id: RC23_0358 briefTitle: Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype acronym: HAP-DEX overallStatus: NOT_YET_RECRUITING date: 2024-02-15 date: 2026-03-14 date: 2026-08-15 date: 2024-02-21 date: 2024-02-21 nam... |
<|newrecord|> nctId: NCT06269887 id: Karabuk-001 briefTitle: Dominant Non-Dominant Upper Extremity in Gender overallStatus: RECRUITING date: 2023-11-07 date: 2024-03-15 date: 2024-03-30 date: 2024-02-21 date: 2024-03-12 name: Karabuk University class: OTHER briefSummary: There are strength and functional differences be... |
<|newrecord|> nctId: NCT06269874 id: ASPERA-ANOCA id: 20240124 type: OTHER domain: JohannesGU briefTitle: Study Comparing Two Administration Pathways for Adenosine During Microvascular Function Assessment acronym: ASPERA-ANOCA overallStatus: NOT_YET_RECRUITING date: 2024-03-02 date: 2024-07-31 date: 2024-08-31 date: 20... |
Goals of this study are: |
1. Agreement and reproducibility between intravenous and intracoronary adenosine administration in the IMR (Index of microvascular resistance) value. |
2. Agreement and reproducibility of FFR(fractional flow reserve), CFR (coronary flow reserve), MRR (microvascular resistance reserve), RRR (resistive reserve ratio) and reproducibility of each of these as compared with CFRabs (absolute coronary flow). |
3. Time required for IMR measurements conditions: Microvascular Coronary Artery Disease studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Patients will be randomized 1:1 to one of the two study arms and then the following study procedures will repeated... |
<|newrecord|> nctId: NCT06269861 id: GaziUtipNBDundar003 briefTitle: Comparison of Body Weights Via Visual Estimation, Anthropometric Calculation, and Actual Measured in Critically Ill Patients overallStatus: RECRUITING date: 2023-11-01 date: 2024-08-31 date: 2024-10-31 date: 2024-02-21 date: 2024-02-21 name: Gazi Univ... |
The all calculations will be performed by a different doctor other than the primary care physician. whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 200 type: ESTIMATED name: patient transfer scale measure: determining actual weight measure: determining the ideal estimated body weight in critically ill pati... |
<|newrecord|> nctId: NCT06269848 id: ITaDeBo briefTitle: Identification of Sports Talents in Boxers overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-29 date: 2024-03-11 date: 2024-06-30 date: 2024-02-21 date: 2024-03-01 name: Dynamical Business and Science Society - DBSS International SAS class: NETWORK briefSummary:... |
<|newrecord|> nctId: NCT06269835 id: NAOTAN-IOE briefTitle: Intermittent Multifunctional Nutrition Tube in Cerebral Palsy and Dysphagia overallStatus: RECRUITING date: 2024-02-28 date: 2024-12 date: 2024-12 date: 2024-02-21 date: 2024-03-06 name: Zeng Changhao class: OTHER briefSummary: This was a randomized controlled... |
<|newrecord|> nctId: NCT06269822 id: SSR, HRV, QEEG in TLE briefTitle: Autonomic Dysfunction in Temporal Lobe Epilepsy and SUDEP overallStatus: COMPLETED date: 2022-09-01 date: 2023-11-25 date: 2024-01-01 date: 2024-02-21 date: 2024-02-21 name: Cairo University class: OTHER briefSummary: The study aimed at detection of... |
Moreover, it aimed at finding any correlation between electrophysiological tests and SUDEP risk. conditions: Temporal Lobe Epilepsy studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: OTHER count: 54 type: ACTUAL name: Sympathetic skin response, heart rate variability test, quantitative EEG measu... |
<|newrecord|> nctId: NCT06269809 id: s67279 briefTitle: Temporary Artery Clipping for Robotically-assisted Myomectomy, a Multicentric Randomized Controlled Trial acronym: TACROM overallStatus: RECRUITING date: 2023-05-04 date: 2025-05-30 date: 2025-05-30 date: 2024-02-21 date: 2024-02-21 name: Universitaire Ziekenhuize... |
<|newrecord|> nctId: NCT06269796 id: little-dcdq briefTitle: Identification of Neuromotor Signs in Preschool Children Suspected of Developmental Coordination Disorder overallStatus: COMPLETED date: 2021-03-01 date: 2021-07-31 date: 2021-09-30 date: 2024-02-21 date: 2024-04-03 name: University of Thessaly class: OTHER b... |
<|newrecord|> nctId: NCT06269783 id: STUDY00022968 briefTitle: Dual-process Mechanisms of Action for sipIT Intervention Effects in Patients With Urolithiasis overallStatus: RECRUITING date: 2024-01-10 date: 2024-10-31 date: 2024-10-31 date: 2024-02-21 date: 2024-02-22 name: Penn State University class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06269770 id: Tapentadol briefTitle: Tapentadol vs Tramadol in Total Knee Arthroplasty overallStatus: RECRUITING date: 2023-05-01 date: 2025-05-01 date: 2025-06-01 date: 2024-02-21 date: 2024-02-22 name: University of Thessaly class: OTHER briefSummary: Compare the effectiveness of tapentadol and... |
<|newrecord|> nctId: NCT06269757 id: 23-01514 briefTitle: Exercise Program for ITB Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-08-01 date: 2026-04-01 date: 2024-02-21 date: 2024-02-21 name: NYU Langone Health class: OTHER briefSummary: Patients with diagnosed iliotibial band (ITB) syndrome in... |
<|newrecord|> nctId: NCT06269744 id: 23-01032 briefTitle: Proactive Outreach With FIT acronym: PROOF overallStatus: ENROLLING_BY_INVITATION date: 2024-03-13 date: 2025-07-31 date: 2026-04-30 date: 2024-02-21 date: 2024-03-29 name: NYU Langone Health class: OTHER briefSummary: The purpose of the study is to boost colore... |
<|newrecord|> nctId: NCT06269731 id: Thyroid cancer briefTitle: Anxiety & Depression in Thyroid Cancer Patients overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-12 date: 2026-03 date: 2024-02-21 date: 2024-02-21 name: Assiut University class: OTHER briefSummary: 1. To identify the prevalence of both anxiety a... |
2. To assess quality of life in thyroid cancer patients conditions: Thyroid Cancer studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 159 type: ESTIMATED name: Hamilton depression Rating Scale measure: the prevalence of anxiety in thyroid cancer patients measure: the prevalence o... |
<|newrecord|> nctId: NCT06269718 id: CMRPG8N0471 briefTitle: The Changes of Masticatory / Swallowing Functions and Oropharyngeal Muscle Mass on Sonography After Comprehensive Swallowing Training and Tongue - Pressure Resistance Training in Stroke Patients With Dysphagia overallStatus: RECRUITING date: 2023-12-01 date: ... |
1. Comparing the ultrasound imaging performance of swallowing and chewing function, tongue pressure and oropharyngeal muscle thickness in stroke patients with different levels of swallowing function |
2. To explore the changes in clinical mastication and swallowing functions, tongue pressure and oropharyngeal muscle thickness in patients with dysphagia and stroke after swallowing treatment and neuromuscular electrical stimulation training. |
3. To explore the correlation between clinical mastication and swallowing functions, tongue pressure, oropharyngeal muscle thickness and ultrasound imaging results in patients with dysphagia and stroke. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPur... |
<|newrecord|> nctId: NCT06269705 id: 006-C-301 briefTitle: ZILRETTA in Subjects With Glenohumeral Osteoarthritis overallStatus: RECRUITING date: 2024-02-05 date: 2025-08 date: 2025-08 date: 2024-02-21 date: 2024-04-03 name: Pacira Pharmaceuticals, Inc class: INDUSTRY briefSummary: Primary Objective: To assess the effic... |
Secondary Objective: |
* To assess the efficacy of ZILRETTA on pain following an IA injection in subjects with glenohumeral OA relative to triamcinolone acetonide injectable suspension, immediate release (TCA-IR) and normal saline placebo |
* To assess the safety of ZILRETTA in subjects with glenohumeral OA relative to normal saline placebo and TCA-IR conditions: Glenohumeral Osteoarthritis studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Only unblinde... |
<|newrecord|> nctId: NCT06269692 id: 2023-A01353-42 briefTitle: MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators acronym: SMART-DEF overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2030-04-01 date: 2030-04-01 date: 2024-02-21 date: 2024-02-21 name: Central Hospital, Nancy, France cl... |
Ventricular tachycardia (VT) and/or ventricular fibrillation (VF), which are responsible for most SCDs, result from the presence of surviving myocytes embedded within fibrotic MI-scar. The presence of these surviving myocytes, as well as their specific arrhythmic characteristics, is not captured by LVEF. Hence, the use... |
<|newrecord|> nctId: NCT06269679 id: RC23_0336 briefTitle: CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis. acronym: 3D STARS overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-05-01 date: 2028-05-01 date: 2024-02-21 date: 2024-02-21 name: Nantes Univers... |
Thus, conducting a randomized controlled trial is highly desirable to assess the potential impact of a clinical examination/CBCT approach on the oral health status of patients hospitalized for IE and potentially to reduce IE new episodes. conditions: Infective Endocarditis studyType: INTERVENTIONAL phases: NA allocatio... |
<|newrecord|> nctId: NCT06269666 id: OPT1100 briefTitle: P200TxE Diseased Eye Image Collection overallStatus: RECRUITING date: 2024-01-31 date: 2024-06-30 date: 2024-06-30 date: 2024-02-21 date: 2024-02-21 name: Optos, PLC class: INDUSTRY briefSummary: The primary objective is to collect images on the P200TxE device in... |
<|newrecord|> nctId: NCT06269653 id: 10001944 id: 001944-AG briefTitle: Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide overallStatus: RECRUITING date: 2024-05-01 date: 2026-03-01 date: 2026-03-01 date: 2024-02-21 date: 2024-04-26 name: National Institute on Aging (NI... |
Proteins are essential to the health and structure of the cells that make up body tissues. Most proteins become damaged over time and are replaced with new ones. This process is called "protein turnover." Stress, disease, and aging can affect this process. Researchers want to better understand how aging affects protein... |
Objective: |
To measure rates of protein turnover in healthy adults. |
Eligibility: |
Healthy people aged 20 years and older with a body mass index between 20 and 30. |
Design: |
Participants will have 6 study visits over 4 to 6 weeks. They will fast 12 hours before each visit. |
Participants will be screened. They will have a physical exam, with blood and urine tests and tests of their heart function. They will lie down while blood pressure cuffs are used on their arms and legs. |
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