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The present invention relates to a new and distinct cultivar of Coral Bells in the Saxifragaceae family and given the cultivar name of ‘Smoke and Mirrors’. Heuchera ‘Smoke and Mirrors’ was hybridized by the inventor on Apr. 18, 2013 at a wholesale perennial nursery in Zeeland, Mich., USA and assigned the breeder code 13-610-1. The seed or female parent was the proprietary, unreleased and unnamed hybrid assigned the breeder code 12-242-08 (not patented) and the male parent was the proprietary unreleased and unnamed hybrid assigned the breeder code K11-52-15 (not patented). Heuchera ‘Smoke and Mirrors’ was first selected in the fall of 2015 and passed final evaluation in the fall of 2017 from among thousands of other seedlings from the same cross and hundreds of other crosses. Heuchera ‘Smoke and Mirrors’ has been asexually propagated by division at the same nursery in Zeeland, Mich. in 2015 and by careful shoot tip tissue culture propagation, and the resultant plants have remained stable and continued to exhibit the same characteristics as the original plant for multiple generations.

All wire-free communication applications require so-called low noise amplifiers (LNA) in order to amplify the input signal as far as possible without additional noise. Since ever higher frequencies are used in wire-free communication applications, it becomes necessary to adapt the low noise amplifiers in such a way that they are suitable for said higher frequencies. Furthermore, the power loss of the low noise amplifiers or of an entire receiver in which a low noise amplifier is incorporated should be kept as small as possible. Typical examples of low noise amplifiers are disclosed. In order still to achieve a sufficient gain of the low noise amplifiers even at high frequencies, coils are usually used in the design of circuit layouts. Coils that are provided for such applications generally have high quality factors, as a result of which it becomes possible to use the relevantly equipped low noise amplifiers. One disadvantage of using coils, however, is that they usually lead to a low available bandwidth of the receiver, that is to say that, when using coils, increasing the quality factor of the low noise amplifier is accompanied by a reduction of the bandwidth available for the use of the low noise amplifier. It can happen in this case that the bandwidth of the low noise amplifier does not suffice to process the bandwidths required for present-day wire-free communication applications. One possibility for compensating for this disadvantage is to provide a plurality of capacitances in the circuit layout which are connected in parallel with the coil and together with the latter form a resonant circuit. Said capacitances are typically embodied as so-called metal to metal capacitances (MIMCaps). By using such capacitances in low noise amplifiers, it is possible to increase the bandwidth of the signals which can be processed by the low noise amplifiers, but by the same token the quality factor of the low noise amplifiers is reduced in this case. One possibility for shifting the center frequency, i.e., the resonant frequency, of such a resonant circuit is to use switches, e.g., transistors, which are connected in series with the MIMCaps. The transistors make it possible for individual ones of the capacitances incorporated to be connected and disconnected, as a result of which the resonant frequency, i.e., the center frequency, of the resonant circuit is varied, i.e., the resonant circuit is detuned. Such a detuneable low noise amplifier is disclosed, by way of example. For these and other reasons, there is a need for the present invention, including providing an integrated amplifier, an electronic communication unit with integrated amplifier and a method for operating the electronic communication unit with integrated amplifier, the integrated amplifier having a smaller space requirement, compared with the low noise amplifiers known in the prior art.

Multilayer optical films are known. Such films typically incorporate a large number of very thin layers of different light transmissive materials, the layers being referred to as microlayers because they are thin enough so that the reflection and transmission characteristics of the optical film are determined in large part by constructive and destructive interference of light reflected from the layer interfaces. Depending on the amount of birefringence (if any) exhibited by the individual microlayers, and the relative refractive index differences for adjacent microlayers, and also on other design characteristics, the multilayer optical films can be made to have reflection and transmission properties that may be characterized as a reflective polarizer in some cases, and as a mirror in other cases, for example. Reflective polarizers composed of a plurality of microlayers whose in-plane refractive indices are selected to provide a substantial refractive index mismatch between adjacent microlayers along an in-plane block axis and a substantial refractive index match between adjacent microlayers along an in-plane pass axis, with a sufficient number of layers to ensure high reflectivity for normally incident light polarized along one principal direction, referred to as the block axis, while maintaining low reflectivity and high transmission for normally incident light polarized along an orthogonal principal direction, referred to as the pass axis, have been known for some time. See, e.g., U.S. Pat. No. 3,610,729 (Rogers), U.S. Pat. No. 4,446,305 (Rogers et al.), and U.S. Pat. No. 5,486,949 (Schrenk et al.). More recently, researchers from 3M Company have pointed out the significance of layer-to-layer refractive index characteristics of such films along the direction perpendicular to the film, i.e. the z-axis, and shown how these characteristics play an important role in the reflectivity and transmission of the films at oblique angles of incidence. See, e.g., U.S. Pat. No. 5,882,774 (Jonza et al.). Jonza et al. teach, among other things, how a z-axis mismatch in refractive index between adjacent microlayers, more briefly termed the z-index mismatch or Δnz, can be tailored to allow the construction of multilayer stacks for which the Brewster angle—the angle at which reflectance of p-polarized light at an interface goes to zero—is very large or is nonexistent. This in turn allows for the construction of multilayer mirrors and polarizers whose interfacial reflectivity for p-polarized light decreases slowly with increasing angle of incidence, or is independent of angle of incidence, or increases with angle of incidence away from the normal direction. As a result, multilayer films having high reflectivity for both s- and p-polarized light for any incident direction in the case of mirrors, and for the selected direction in the case of polarizers, over a wide bandwidth, can be achieved. Some multilayer optical films are designed for narrow band operation, i.e., over a narrow range of wavelengths, while others are designed for use over a broad wavelength range such as substantially the entire visible or photopic spectrum, or the visible or photopic wavelength range together with near infrared wavelengths, for example. Some reflective films are designed to reflect light specularly, such that a collimated incident beam is reflected as a collimated or substantially collimated (e.g., having a full-width-at-half-maximum power of no more than 1.0 degrees, or no more than 0.3 degrees) reflected beam. A conventional household or automotive mirror is an example of a specularly reflective film. Other reflective films are designed to reflect light diffusely, such that a collimated incident beam is reflected into a large cone, such as an entire hemisphere, of different scattering directions—for example, the reflected light may have a full-width-at-half-maximum power of at least 15 degrees, or at least 45 degrees). “Flat white” paint is an example of a diffusely reflective film. In some cases, it is desirable for a reflective film to provide a mixture or suitable balance of specular reflection and diffuse reflection. We refer to such films as “semi-specular” reflective films. One application for such a film may be an edge-lit optical cavity that emits light over an extended area, which may be useable as a backlight, for example. Three such cavities are depicted in FIGS. 1a, 1b, and 1c. An edge-mounted light source may be mounted at the left end of each cavity, but is omitted from the drawings for generality. A pure specular reflector performs according to the optical rule that “the angle of reflection equals the angle of incidence.” This is seen in the hollow cavity 116a of FIG. 1a. There, front and back reflectors, 112a, 114a are both purely specular. A small portion of an initially launched oblique light ray 150a is transmitted through the front reflector 112a, but the remainder is reflected at an equal angle to the back reflector 114a, and reflected again at an equal angle to the front reflector 112a, and so on as illustrated. This arrangement provides maximum lateral transport of the light across the cavity 116a, since the recycled ray is unimpeded in its lateral transit of the cavity 116a. However, no angular mixing occurs in the cavity, since there is no mechanism to convert light propagating at a given incidence angle to other incidence angles. A purely Lambertian (diffuse) reflector, on the other hand, redirects light rays equally in all directions. This is seen in the hollow cavity 116b of FIG. 1b, where the front and back reflectors 112b, 114b are both purely Lambertian. The same initially launched oblique light ray 150b is immediately scattered in all directions by the front reflector 112b, most of the scattered light being reflected back into the cavity 116b but some being transmitted through the front reflector 112b. Some of the reflected light travels “forward” (generally to the right as seen in the figure), but an equal amount travels “backward” (generally to the left). By forward scattering, we refer to the lateral or in-plane (in a plane parallel to the scattering surface in question) propagation components of the reflected light. When repeated, this process greatly diminishes the forward-directed component of a light ray after several reflections. The beam is rapidly dispersed, producing minimal lateral transport. A semi-specular reflector provides a balance of specular and diffusive properties. In the hollow cavity 116c of FIG. 1c, the front reflector 112c is purely specular but the back reflector 114c is semi-specular. The reflected portion of the same initially launched oblique light ray 150c strikes the back reflector 114c, and is substantially forward-scattered in a controlled amount. The reflected cone of light is then partially transmitted but mostly reflected (specularly) back to the back reflector 114c, all while still propagating to a great extent in the “forward” direction. Semi-specular reflectors can thus be seen to promote the lateral spreading of light across the recycling cavity, while still providing adequate mixing of light ray directions and polarization. Reflectors that are partially diffuse but that have a substantially forward directed component may thus transport more light across a greater distance with fewer total reflections of the light rays. Reference is made to PCT publication WO 2008/144644 (Weber et al.). Certain design challenges arise when combining a diffusing layer with an MOF. Reference in this regard is made to PCT publication WO 2007/115040 (Weber), “Wide Angle Mirror System”. The design challenges stem from the MOF effectively being optically immersed in a medium of refractive index greater than air, such that light scattered at highly oblique angles by the scattering layer can propagate through the microlayers of the MOF at angles (“supercritical” angles) that are more oblique than the critical angle for the MOF when immersed in air. This effect, combined with the fact that the reflection band of the MOF shifts to shorter wavelengths as the propagation angle increases, and the fact that the spectral width of the reflection band is limited by the number of optical repeat units (ORUs) of microlayers used in the MOF, can result in some of the scattered light, particularly at longer wavelengths, propagating all the way through the MOF to the back or rear major surface thereof. Any dirt or other disturbances such as absorbing materials that are present on such back major surface may cause that light to be absorbed or otherwise lost, detracting from the total reflectivity of the construction. Some solutions to these design challenges are discussed in the '040 PCT publication. However, additional solutions would be of benefit to optical system manufacturers and designers.

Effects of prenatal yoga on women's stress and immune function across pregnancy: A randomized controlled trial. The effects of prenatal yoga on biological indicators have not been widely studied. Thus, we compared changes in stress and immunity salivary biomarkers from 16 to 36 weeks' gestation between women receiving prenatal yoga and those receiving routine prenatal care. For this longitudinal, prospective, randomized controlled trial, we recruited 94 healthy pregnant women at 16 weeks' gestation through convenience sampling from a prenatal clinic in Taipei. Participants were randomly assigned to intervention (n=48) or control (n=46) groups using Clinstat block randomization. The 20-week intervention comprised two weekly 70-min yoga sessions led by a midwife certified as a yoga instructor; the control group received only routine prenatal care. In both groups, participants' salivary cortisol and immunoglobulin A levels were collected before and after yoga every 4 weeks from 16 to 36 weeks' gestation. The intervention group had lower salivary cortisol (p<0.001) and higher immunoglobulin A (p<0.001) levels immediately after yoga than the control group. Specifically, the intervention group had significantly higher long-term salivary immunoglobulin A levels than the control group (p=0.018), and infants born to women in the intervention group weighed more than those born to the control group (p<0.001). Prenatal yoga significantly reduced pregnant women's stress and enhanced their immune function. Clinicians should learn the mechanisms of yoga and its effects on pregnant women. Our findings can guide clinicians to help pregnant women alleviate their stress and enhance their immune function.

The surgical treatment of anal incontinence. This study is review of 31 patients undergoing surgery for anal incontinence. Three groups of patients are defined--those with incontinence due to trauma (nine patients), to a combination of trauma and degeneration (five patients), and to degeneration alone (17 patients). Two surgical techniques were used--either a direct repair of the anal sphincter or a postanal repair of the levator ani muscles and external sphincter (Parks operation). In the trauma group and the combined group the more common method used was a direct repair (ten patients)--five underwent a Parks operation. In the degeneration group all but one patient underwent a Parks operation. A defunctioning proximal colostomy was carried out in only four patients--all with incontinence due to trauma. Satisfactory continence was restored in 80% of these patients. Although this is a small series, the results are considered worthwhile and greater awareness and use of the above technique is recommended.

An integrative approach considering acute symptoms and intensity ratings of chemosensory sensations during experimental exposures. Even at low concentrations airborne chemicals can excite olfactory and trigeminal receptors and inform the organism about the presence of airborne chemicals. Acutely, malodors or sensory irritations might trigger symptoms (e.g., bad air quality, eye irritations) and in the long-run functional impairment of chemoreception might occur. In humans, knowledge about short-term adaptational processes and effects of exposure peaks on these systems is limited. Therefore, two different experiments with human volunteers were conducted. In experiment A exposures (4h) with fluctuating concentrations of 2-ethylhexanol (1.5, 10, 20ppm C(TWA)) were investigated, experiment B used similar but constant vapor concentrations. Olfactory- and trigeminal-mediated symptoms and intensities of odor, eye, and nasal irritations were recorded. All measures showed a dose-dependent response and peak exposure effects. In the course of the 4h exposures solely olfactory symptoms decreased. Nasal irritations remained nearly unchanged across the 4h, eye irritations slightly increased. Inter-individual differences related to the personality trait of self-reported chemical sensitivity had only minor effects on chemosensory symptoms in experiment B and no effect on intensity ratings in both experiments. Chemosensory effects seem to be amplified by exposure peaks and less adaptive than assumed.

Elevated lipoprotein(a) and increased incidence of restenosis after femoropopliteal PTA. Rationale for the higher risk of recurrence in females? It has been shown that the incidence of recurrent stenosis following successful percutaneous transluminal coronary angioplasty (PTCA) is correlated with serum Lipoprotein(a) [Lp(a)] levels. The aim of the present study was to examine the influence of Lp(a) on restenosis after primary successful femoropopliteal PTA. One hundred and thirty nine consecutive patients with peripheral arterial occlusive disease (PAOD) and successful femoropopliteal PTA were studied. Follow-up included clinical examination and non-invasive laboratory testing (pulse volume recordings, ankle-brachial arterial pressure measurement) in every patient before and after 1, 3, 6 and 12 months following intervention. Duplex sonography was performed 1 year after PTA. Suspicion of restenosis (> or = 50% diameter reduction) was verified by angiography. Lp(a) was determined using ELISA technique (mg/dl). Twelve months after successful PTA no restenosis was found in 82 patients (59%: group A). The one-year recurrence rate of 41% (group B) was due to significant restenosis in 35 patients (25%) and reocclusion in 22 patients (16%). The corresponding mean values +/- S.E.M. for Lp(a) were as follows: group A, 28 +/- 5.3; group B 59 +/- 11 (P < 0.01). Women showed a higher frequency of recurrences (55%) versus men (30%, P < 0.01) also corresponding with a high Lp(a) level (51.8 +/- 8 versus 32.7 +/- 5; P < 0.05). Furthermore Lp(a) aggravated the well known increased risk for recurrence in multiple stenoses or occlusions of > or = 5 cm in length. There were no significant differences between groups A and B with respect to age, diabetes, hyperlipidaemia, obesity and cigarette smoking. The results support the view that Lp(a) is an independent risk factor for recurrence after PTA in the femoropopliteal area. It might also be a causal basis for the higher incidence of recurrences in female PAOD patients.

Benzodiazepine-refractory status epilepticus (Established Status Epilepticus, ESE) is a relatively common emergency condition with several widely used treatments. There are no controlled, randomized, blinded clinical trials to compare the efficacy and tolerability of currently available treatments of ESE. This Statistical and Data Management Center (SDMC) application is linked with the proposal entitled Established Status Epilepticus Treatment Trial (ESETT) from the University of Virginia (Jaideep Kapur, contact PI). These applications jointly describe the ESE treatment trial (ESETT), which is designed to determine the most effective and/or the least effective treatment of ESE among patients older than two years by comparing three arms: fosphenytoin (FOS), levetiracetam (LEV), and valproic acid (VPA). This is a multicenter, randomized, double-blind, Bayesian adaptive, Phase III comparative effectiveness trial. Up to 795 patients will be randomized initially 1:1:1 and response-adaptive randomization will occur after 300 patients have been recruited. Randomization will be stratified by three age groups, 2- 18, 19-65, and 66 years and older. The primary outcome measure is cessation of clinical seizure activity and improving mental status, without serious adverse effects or further intervention at 60 min after administration of study drug. Each subject will be followed until discharge or 30 days from enrollment. This trial will include interim analyses for early success and futility. This trial will be considered a success if the probability that a treatment is the most effective is greater than 0.975 or the probability that a treatment is the least effective is greater than 0.975 for any treatment. This will be the first phase III clinical trial of ESE in children and adults.

This invention relates to a mud flap mounting device, and more particularly to a rotatable mud flap mounting device for use with tractor trailer trucks. Prior mud flap mounting assemblies were susceptible to damage and breakage. Damage to the mounting assembly was frequently encountered when the mud flap assembly came into contact with the support legs of the trailer during the maneuvering of the vehicle. This contact or entanglement would especially occur when the angle between the motorized cab and trailer approached 90.degree. or more. Damage to the mud flap mounting assembly also occurs when the vehicle backs up over curbs or other uneven terrain and the mud flap itself gets caught between an obstacle and the tires of the vehicle. This entanglement of the mud flap causes force on the mounting assembly that results in damage or loss of the assembly. The fraility of prior mounting assemblies also contributed to the susceptibility to damage. Prior mounting assemblies also did not provide a rigid support for the mud flap and, accordingly, exhibited vibration and sway. This vibration or sway eventually weakened the assembly so as to be more susceptible to damage upon contact with obstacles or the support legs of the trailer. Some prior mounting assemblies provided removable mud flap support arms to allow detachment when a trailer is connected to the motorized cab and mud flaps are not required. Detachable parts, however, are susceptible to loss and possible dislodgement due to vibration.

"I'm going to return to the hometown we lost." "That's all I care about now." "I chose to be a soldier in the hopes of joining the Military Police so I could work in the safety of the interior." "Why do you want to be a soldier?" "I..." "I decided I have to kill them." "I decided I have to slaughter all the Titans with my own two hands." "So your encounter with the Titans didn't break your will?" "You'll be able to do it." "Eren Jaeger, was it?" "You damn traitors!" ""Close Combat"" "Eren!" "If only..." "If only I'd cut off their heads!" "That was the perfect chance!" "I should've been able to do it, so why?" "!" "That was it." "There won't be another chance!" "Everyone, jump away from the wall!" "It got Ymir!" "And somebody else, too!" "He ate 'em!" "Th-This can't be..." "Bertholdt..." "All soldiers, prepare to attack!" "We're taking down the Colossal Titan!" "It's a threat to all of humanity!" "Swarm the huge bastard!" "Just like the reports said, he's slow!" "It might be big, but that's it!" "Compared to the Titans we normally fight, this'll be easy!" "We've got this!" "Now's our chance!" "Slice up his neck!" "Too hot!" "Everyone, fall back!" "My hand!" "Water!" "Bring water!" "He's trying to disappear again?" "No, something is different." "The last time he vanished instantly, but now, he's maintaining his form and emitting heat like a furnace." "If he keeps protecting himself with steam..." "We're unable to attack him with ODM gear!" "Wh-What do we do?" "!" "We can't do anything." "We wait." "Squads three and four, take position behind the target." "Rashad has command." "Got it!" "Squad two will wait here." "Lauda is in command." "Understood!" "It's yet to be seen how long he can keep his body burning, but eventually he has to come out." "We wait for that moment to attack." "Listen up." "Forget about capturing them." "Kill 'em and don't hesitate!" "Armin... and squad one follow me!" "We've got a date with the Armored Titan!" "Hot!" "Christa!" "Conny!" "Get further back!" "And take care of those two injured soldiers." "U-Um!" "Huh?" "Ymir can't possibly be dead yet." "Please..." "Rescue her!" "Right." "Where are Reiner and Bertholdt?" "!" "They don't have their ODM gear either!" "Please, go find and help those two!" "You shit..." "You big piece of shit." "And here you wouldn't shut up about a soldier's duty..." "During close combat training, were you always holding back on me?" "You're so strong, it's ridiculous." "I can't even move an inch of my body." "I always thought you were a stand-up guy." "Someone who remained calm, regardless of the situation..." "A guy who put your comrades ahead of yourself..." "And I..." "To think at one time I wished..." "to be as strong as you someday." "That did nothing!" "Eren's attack didn't..." "And my blades don't work either?" "!" "What's worse, unlike Annie, his whole body is hard!" "Eren!" "Hey, Reiner..." "I don't know what kind of face you're making right now, but..." "You guys..." "You really are the worst pieces of shit." "I bet in the history of mankind, nobody's done anything as terrible as you." "I've gotta erase you." "You shouldn't be allowed to exist anymore." "What the hell are you thinking?" "I've never felt so revolted before." "Just remembering you and your self-righteous face is making me sick." "It makes me want to vomit." "You... big damn pest!" "It's time to exterminate you!" "Damn, that hurt, Annie!" "Haven't you ever heard the concept of pulling your punches?" "I did it because you're coming at me full-force." "I've gotta respond with equal strength of my own." "And if you're a guy aren't you... supposed to be gentle with this delicate body of mine?" "Huh?" "Your jokes aren't funny at all." "If strength is the deciding factor, then why am I on my ass and you're still standing?" "Well..." "I didn't throw you using my strength." "It's a technique used to protect yourself against an opponent stronger than you." "If I were you, I'd think about learning it." "All right, already!" "Why don't we take a break?" "Annie!" "Surrender!" "I surrender!" "Surrender?" "Try to learn something first before you surrender." "Learn how to use your strength and the proper way to speak to women!" "All right!" "I promise I'll learn, so let go already!" "Yeah?" "Do you want to learn that badly?" "Why the hell did Reiner come flying this way?" "Hey, Annie." "I wanna learn that move, too." "Show me." "I don't know..." "That move is meant to be used against humans, so I don't think you have any use for it." "But..." "I'm interested to see if it works on a beast like you." "Are you serious?" "It's happening..." "Hey, hey!" "Are they going at it?" "It's the big showdown!" "...Who'll win?" "!" "...Annie, you think?" "...Who'll win?" "!" "Huh?" "Are you stupid?" "!" "I bet my whole dinner on Mikasa!" "What do you think, Eren?" "I..." "Which one, I wonder?" "Huh?" "How did that turn out in the end?" "No..." "Why am I remembering it now?" "Is this what they call having your life flash before your eyes?" "Actually, who gives a shit anymore?" "I don't think I've felt..." "this awful in my whole life." "Eren!" "Don't do it!" "You can't win in a slugfest!" "Run this way!" "Eren!" "Don't try to fight him!" "Eren!" "This is bad!" "Did he lose control?" "!" "He threw the Armored Titan!" "Wait..." "Isn't that the technique Annie used?" "I don't know what the hell you guys are trying to accomplish by doing all this, but..." "Now that I think of it, your plan has been full of flaws from the start!" "Your biggest mistake was this!" "You should've thought twice about teaching me how to fight!" "It's working!" "I've got him now!" "I still have a chance!" "Think again!" "Eren!" "You're not getting away from this!" "He did it!" "Eren!" "Can you hear me?" "!" "Run away!" "Get closer to the wall!" "Their goal is to kidnap and take you away!" "We've gotta escape and prevent that from happening!" "But, Armin, Reiner isn't going to let us do as we please!" "It's dangerous here!" "Get back, you two!" "Huh?" "Nice, Eren!" "Good call!" "He's back in control again." "Yeah, but like you were saying, it'll be almost impossible to escape Reiner." "What the hell?" "I knew it..." "The Colossal Titan." "Why did that bastard show up here?" "!" "Where's Eren?" "What's the situation?" "Eren and the others are that way!" "Eren?" "!" "Is that Eren's Titan form?" "Listen up, Eren." "If you're gonna escape, we've got to find a way to halt Reiner and buy you some time!" "Can you break his leg with another one of those joint locks?" "Our blades don't seem to work on him, so use your head and figure out the best course of action!" "Mikasa!" "Use these." "It's the rest of my blades." "I'm counting on you!" "This time, running away is a guaranteed victory." "It's you guys that are screwed for revealing what you are." "You're the ones backed into a corner." "He's fast!" "Shit!" "Leg!" "His leg!" "Don't stay on the ground!" "Eren!" "Stand up!" "Dammit!" "His tackle is too much to handle!" "Shit..." "Since when could he move so quick?" "Are we completely useless here?" "!" "No..." "If his entire body was hard like stone, there's no way he could move like that." "In the armor they used in wars of the past, it had sections at the joints not covered in metal to allow for movement." "Like at the armpits and groin..." "And also... the spot behind the knee." "I can't evade it..." "Since I'll get knocked over anyways..." "Bring it!" "Gimme that neck!" "You're mine!" "Yeah!" "That's it, Eren!" "I've got 'em!" "Now it's a battle of strength!" "This freak..." "Not enough!" "Mikasa!" "She cut him!" "He can't fight back as much anymore!" "You've got this!" "Go for it, Eren!" "Tear the head off his neck!" "Pull the traitor outta there!" "I can win!" "Against Reiner..." "I can win!" "Wh-What the...?" "Heh, it's useless." "Keep at it!" "Don't let up!" "He stopped..." "But why there?" "Be on your guard!" "He's calling in Titans!" "No other Titans spotted in the area!" "What a useless struggle." "Try screaming for help with your head ripped off, you idiot!" "Look, he's tearing it off!" "What's with the Armored Titan?" "Why'd he scream like that?" "Hey..." "Hey, hey, hey, hey, hey!" "Above you!" "Look out!" "The battle between Eren and the Armored Titan comes to an abrupt conclusion." "With its fall from the wall," "Mikasa is injured by the Colossal Titan and Hannes comes running to her side." "To protect Eren through his reckless behavior... to stand proudly at his side that is, and has always been, the wish of Mikasa and Armin." "Next episode: "The Hunters.""

This type of rotary damper generally includes a damper body including a receiving hole with a bottom portion formed therein, a rotor rotatably fitted in an opening side end portion of the receiving hole, a piston movably disposed in a portion of the receiving hole between the rotor and the bottom potion, and movement means that causes the piston to be moved according to the rotation of the rotor. Inner space of the receiving hole between the rotor and the bottom portion is divided by the piston into a first chamber and a second chamber. The first and second chambers are filled with fluid such as viscose fluid. The movement means includes a cam mechanism disposed between the rotor and the piston and a coil spring that biases the piston toward the rotor. The cam mechanism allows the piston to be moved by the coil spring toward the rotor when the rotor is rotated in one direction. On the other hand, when the rotor is rotated in the other direction, the cam mechanism causes the piston to be moved in a direction away from the rotor against a biasing force of the coil spring. When the piston is moved toward the rotor, the viscose fluid in the first chamber flows into the second chamber. Flow resistance of the viscose fluid at this time limits the speed of rotation of the rotor in the one direction to a low speed. When the piston is moved to the other direction, the viscose fluid in the second chamber flows into the first chamber. The flow resistance at this time is kept to be negligibly small. Therefore, the rotor can be rotated in the other direction at a high speed. When the rotary damper described above is used in a toilet, for example, the damper body is fixed to either one of a toilet body and a toilet lid and the rotor is fixed to the other. In this case, the damper body and the rotor are fixed to the toilet body and the toilet lid such that the rotation speed of the toilet lid is limited to a low speed when the toilet lid is rotated in a closing direction and the toilet lid can be rotated at a high speed when rotated in an opening direction. When the toilet lid is rotated through about 90 degrees from a closed position and the piston is moved to a predetermined position toward the rotor, the piston becomes rotatable in the one direction. As a result, the rotor becomes rotatable together with the piston in the one direction, allowing the toilet lid to be rotated through more than 90 degrees. Moreover, the coil spring rotationally biases the piston in the one direction. Therefore, after being rotated through 90 degrees from the closed position, the toilet lid is further rotated in the opening direction by the rotational biasing force of the coil spring. The toilet lid is stopped when it is abutted against a tank disposed in the toilet (refer to Patent Document 1).

Gender differences in the magnitude of the associations between eating disorders symptoms and depression and anxiety symptoms. Results from a community sample of adolescents. Studies reporting comorbidities of eating disorders (EDs) with depression and anxiety disorders during adolescence used clinical samples of female adolescents with few attempts to present the magnitude of these associations in population-based samples and to assess gender differences in the strength of these associations. This study assesses significant gender differences in the association of anorexia nervosa (AN) and bulimia nervosa (BN) symptoms with depression and generalized anxiety symptoms in a community sample of adolescents. We collected anonymous self-reported data from 235 adolescent boys and 471 adolescent girls, through an online platform. To identify correlations between symptoms of AN and BN, and symptoms of depression and generalized anxiety, we used the Mann-Whitney U test. To identify differences between independent correlation coefficients, we converted each correlation coefficient into a z-score using Fisher's r-to-z transformation and, making use of the sample size employed to obtain each coefficient, we compared the z-scores. The magnitude of the associations between EDs symptomatology and depression and anxiety symptomatology was similar in adolescent boys and girls. Our results show an urgent need to address EDs prevention in adolescent girls and boys from the community.

Heretofore, a mold type composition of frictional material using asbestos as matrix fibers and a phenolic resin as a binder has generally been employed as composition of frictional materials for use in brake linings. This conventional molded type composition of frictional material for use in brake linings contains as a binder an organic substance which is thermally decomposed at high temperature, and therefore fadings, i.e., lowering of the frictional coefficient compared to the required coefficient, are resulted. Recently, the brake linings using glass fibers or aromatic polyamide fibers instead of asbestos have been reported, as disclosed in Japanese Patent Laid-Open Publications Nos. SHOWA 53-130742 and SHOWA 56-16579. Since aromatic polyamide fibers are organic substances as well as a phenolic resin, fadings are resulted when aromatic polyamide fibers are thermally decomposed in braking. Also, Japanese Patent Laid-Open Publication No. SHOWA 57-205473 discloses the cryolite powder is blended in a composition of frictional material for use in brake linings an inorganic grain. As described above, for the conventional composition of frictional material for use in brake linings containing asbestos as matrix fibers, there has been known such problems that the friction coefficient is substantially low or fadings are resulted when brakes are frequently operated. While, a mold type composition of frictional material for use in brake linings containing aromatic polyamide fibers as matrix fibers and a phenolic resin as a binder, possibly lowers the anti-fading performance because of containing a large quantity of the organic substances. The object of this invention is to provide a new molded type composition for use in brake linings by using polyparaphenylene terephthalamide as matrix fibers of a superior anti-fading performance and a phenolic resin as a binder in order to exhibit a high friction coefficient and a lower wear ratio.

Monoclonal antibodies against recombinant-MAGE-1 protein identify a cross-reacting 72-kDa antigen which is co-expressed with MAGE-1 protein in melanoma cells. The MAGE-1 gene codes for tumor-associated peptides recognized by cytolytic T lymphocytes in association with MHC-class-1 molecules such as HLA-A1 and HLA-Cw16. In the course of a study aiming at the immunohistochemical detection of the MAGE-1 gene product in tumor samples, 2 mouse monoclonal antibodies (MAbs) directed against a full-length recombinant MAGE-1 fusion protein were found to react strongly not only with the 46-kDa MAGE-1 protein, but also with a 72-kDa product in immunoblots of lysates obtained from several MAGE-1-mRNA-positive melanoma cell lines. Pre-incubation of the antibodies with the recombinant MAGE-1 fusion protein abolished their reactivity both with MAGE-1 protein and with the 72-kDa product, thus confirming the occurrence of antigenic determinant(s) shared by the 2 proteins. The 72-kDa protein is not an alternative product of MAGE-1, since it was still detected in lysates of a MAGE-1 loss variant derived from a MAGE-1-positive melanoma cell line. Moreover, the 72-kDa protein does not appear to be a product of the other members of the MAGE gene family known to be expressed in tumors (such as MAGE-2, -3, -4 and -12). Interestingly, expression of the 72-kDa protein was found to be correlated with that of MAGE-1 protein. Thus, in 30 tumor cell lines analyzed by immunoblotting and RT-PCR, the 72-kDa protein was never detected in MAGE-1-mRNA-negative cell lines, while it was co-expressed with MAGE-1 protein in 12 out of 15 cell lines expressing MAGE-1. Furthermore, the 72-kDa protein was detected in lysates of human testis, the only normal tissue known to express MAGE-1. Finally, treatment of MAGE-1-mRNA-negative cell lines with 5-Aza-2'-deoxycytidine, a hypomethylating agent known to induce MAGE-1 expression, resulted in the expression of the 72-kDa protein. Taken collectively, these findings suggest that expression of the gene encoding the 72-kDa protein identified in this study through antigenic determinant(s) shared with MAGE-1 protein is regulated in a way similar to that of MAGE-1.

A conventional boiling water reactor (BWR) includes a reactor core including a plurality of laterally spaced apart nuclear fuel bundles immersed in water. Each of the fuel bundles includes a plurality of fuel rods joined together in a conventional square array, for example, which are completely surrounded on four sides by a correspondingly square fuel or flow channel or tube. The bottom of the flow channel is joined to a conventional conical nosepiece through which water is channeled into the flow channel and upwardly between adjacent ones of the fuel rods and outwardly from an outlet at the top of the flow channel. Adjacent fuel bundles are laterally spaced apart to define bypass channels between adjacent ones of the flow channels which bypass upwardly water flow around the flow channels. Furthermore, conventional cruciform control rods are also disposed in selected ones of the bypass channels and are selectively translatable upwardly and downwardly for being inserted and withdrawn between adjacent fuel bundles for controlling reactivity of the core fuel. During operation of the reactor, water is channeled upwardly inside each of the fuel bundles within the flow channels and in parallel flow upwardly between adjacent fuel bundles through the bypass channels. The water inside the fuel bundles is progressively heated and boiled for generating steam which is conventionally used as a power source. The water channeled upwardly through the bypass channels, however, receives less heat from the fuel rods than the water inside the flow channels and does not boil or generate any substantial amount of steam. Accordingly, the bypass water is more effective as a neutron moderator than the water being boiled inside the flow channels and effects neutron flux peaking around the perimeter of the fuel bundles which varies the degree of reactivity and corresponding output power through each of the fuel bundles. In order to obtain a more uniform output power from each of the fuel bundles, a conventional fuel bundle typically includes less enrichment in the fuel rods around the perimeter of each of the fuel bundles which increases the cost of manufacturing the fuel bundles. Furthermore, the flow channels around each of the fuel bundles are required to ensure that the water is progressively heated and boiled as it flows upwardly along the fuel rods for controlling the resulting steam void fraction. The flow channels, therefore, confine the water flow within each of the flow channels and prevent lateral crossflow of the water between adjacent fuel bundles for ensuring acceptable reactor performance. Furthermore, the spaced apart flow channels also provide the bypass channel therebetween through which the conventional cruciform control rods may be selectively translated for controlling reactivity of the core fuel. However, the pressure within each of the flow channels varies longitudinally from the bottoms to the tops thereof, and a differential pressure exists across each of the flow channels from the inside thereof to the outside thereof in the bypass channels. The pressure of the boiling water inside the flow channels is greater than the pressure of the water being channeled upwardly through the bypass channels which produces pressure forces acting on the flow channels. Over the course of operation of the reactor core, such pressure forces typically lead to permanent distortion of the flow channels which requires the replacement thereof at periodic intervals. Conventional flow channels are typically subject to expansion thereof from thermal expansion and from irradiation growth due to the neutrons released during nuclear reactions. For example, conventional flow channels are typically made of conventionally known Zircaloy which expands during operation of the reactor core, which expansion leads to additional permanent distortion of the flow channels during operation. Accordingly, the fuel channels are replaced relatively frequently, for example once per fuel bundle lifetime, which increases the cost of maintaining the nuclear reactor.

Suicide attempts in hospital-treated epilepsy patients. Persons suffering from epilepsy are in the group of patients at an increased suicide risk. The basis of every suicidal behavior, including patients suffering from epilepsy, is depression, and to explore the causes of suicidal behavior in epileptics it is necessary to find the causes responsible for the development of depression. Depression is caused by numerous factors divided into psychosocial factors, factors of the illness, and antiepileptic medication factors. The aim of the study was to identify the causes of suicidal behavior in epileptics treated in our hospital. The study included patients suffering from epilepsy treated at our Department from January 1 to December 31, 2009. Based on medical history, patients having attempted suicide were allocated to the experimental group and those without a history of suicidal attempt in the control group. Characteristics of the groups in relation to age and sex were defined first, followed by defining variables used in both groups, i.e. psychosocial factors (marital status, employment status, family environment, psychiatric comorbidity) and disease factors (etiology, type of seizures, duration of the disease, attitude towards treatment, attitude towards illness). Statistical significance was recorded in two psychosocial variables, i.e. family environment, which was significantly better in control group, and psychiatric comorbidity, which was more frequently present in patients having attempted suicide. Study results showed even 14.6% of epilepsy patients to have attempted suicide. Poor family atmosphere and psychiatric comorbidity had a significant role in suicidal behavior. In our study, the variables associated with the disease had no effect on suicidal behavior in epilepsy patients.

"1939., USSR and Germany concluded nonaggression pact." "After only a week ago started the Second World War." "1940, the Soviet Union annexed Estonia." "55000 Estonian citizens were mobilized the Red Army." "1941 ve years, Germany is occupied Estonia." "72000 Estonian citizens were mobilized the German armed forces." "In 1944, the Soviet army appeared on the borders of Estonia." "The gate was open." "In the courtyard stood a truck." "Father, mother and Kadri was made ?" "into a truck." "As it's the most normal thing in the world." "27 th July Line Sinimad-Tannenberg" "What happened to them?" "They sent them to Siberia." "Could not you have something to preduzmeš?" "Treci Online!" "Saaresto on the phone!" "Twentieth Estonian division Waffen-SS." "47-mi Regiment, Third Battalion, Ninth armies, the third line ..." "They captured the Children's hill." "The third line ..." "Shit!" "The line went dead!" "Tamika, back!" "Carl!" "The third line ..." "I get it!" "We will make such a task!" "Let's go!" "Karl!" "How are you?" "I'm fine." "Let's go!" "Three years have passed." "Three years and 43 days" "I can not help feeling that I I was to blame for everything that happened to them." "I try to remember their faces, movements, voice ..." "Memories of them slowly fade and my guilt is increasing day by day." "This is my cross, and I'll have to wear it for life." "Charge!" "Infantry at 800 meters from us!" "That's why you're here?" "Fire!" "Swap!" "Bring the ammo!" "Karl!" "Medic!" "Sjajnas, over here!" "Pir, come on!" "Radik, cover us!" "I got him!" "Fire!" "Are you from the same village?" "We did not." "Talu chosen me to be his assistant." "Steady!" "Who are you two?" "SS Rows Kjaer." "Hit the deck!" "Leave it!" "Dismissed!" "Staffing?" "Yes." "They promised to send 10 and only two in." "And the twins." "What is your name?" "Skin." " Anton." "Karl Tamika." "Relatives?" "Brac." "I immediately noticed that his face." "Radik." "I arrived this spring." "Sjajnas, a paramedic." "Kamenski, snipers." "Powder, commander of the department." "Pir, only that." "Saaresto is our commander." "Taking care of you as Jesus." "These rods will not serve anything on the front." "Put it there!" "And a gas mask, you can throw it away." "Now here you can put something what is more necessary." "Letters of girls, tobacco, condoms ..." "Sit down!" "Take this!" "This is a reliable weapon." "In the First World War were fought my two brothers." "Both were killed by the same missile." "Horrible smells." "les." "We can not bury them until the shooting outside." "This goes here." "Needs an assistant to me." "I will." "Can I do." "Radik, show him the position!" "Let's go!" "I will look at it." "The machine gun was always the first to be affected." "Then take me." "I promised my mother I'd take care of his brother." "I'm older than him." "How much?" "Half an hour." "You'll be my assistant." "I want you and me." "Next time." "This put here ..." "You're all I have left." "It's not easy to admit" "I'm hiding from you the real truth." "After the deportation of parents I walked as in a dream." "I saw only one way out:" "On the front." "You made ?" "me discouraged ..." "Who do you keep writing?" "The girl?" "Parents?" "What is wrong with you?" "I can not sleep." "The boys first day on the front line and you're talking about their tales." "It is a strange feeling." "As if I knew them." "It's like ..." "I see myself in their place." "Nasty feeling." "Hands in the air!" "I forgot to take off the lid." "Saaresto ordered to wake the boys." "The Russians entered the adjacent trench." "Do not you hear?" "You're a lucky man." "Here we are, here Russians." "Here are our trapped." "Eighth troop attacks here." "We charge here." "Here is a minefield." "There is a passage." "It is used to force the Russians into a trap." "Any questions?" "How many Russians there?" "Well, there's a little something." "July 28" "The first mine is about 10 meters." "Keep up that tree." "Do not shoot!" "We Estonians!" "Put your head down!" "The Russians are!" "Where is your commander?" "Died in combat is." "We are from Nordlandske Division." "How many are you?" "4 Soldiers and two machine guns." "Oberšarfirer (rank in the German army) Saaresto." "Taking command." "We will attack with your position." "Giving fire!" "I get it!" "We have some more ammunition?" "We do not have." "We start at exactly 4:00 in the morning." "Got it!" "Thank you." "What's your name?" "Carl." "Me too." "I am Charlemagne." "Then I called Karl-XXII." "I'm Karl Madsen of Roskilde." "It is 30 kilometers from Copenhagen." "Karl Tamika." "On the farm Tamika." "Three kilometers from Vinimajzea." "The Germans!" "The Germans, the Germans in the trenches!" "Let's go, or we're done!" "Retreat!" "Dragging quickly!" "Get down!" "Bomb!" "Are you okay?" "Powder, blow the door!" "15 seconds!" "Sjajnas, Pyrrhus was wounded!" "They ran to the other exit." "Do not shoot!" "Do not shoot, we surrender!" "Do not shoot ... 18th August" "Steady!" "Hi, guys!" "I see here a wash." "There can be war." "Estonian soldiers." "Fuhrer pointed our people a lot of confidence." "He confided in us is the most difficult task:" "Tanenburšku line." "And we, the local Estonian authorities, do not sit idly by." "After years of research" "We have proved that we belong Aryan race." "It is an indisputable fact." "Under the auspices of the Greater German state bright future awaits us in a joint family and European nations." "Heil Hitler!" "I do not think so." "Why?" "Heil Hitler!" "I thought we'd get Gvozd one baptism and not this." "What do I do with this?" "Can her to wipe my ass." "Paper Is too thick." "And you're condition." "You can replace the tobacco." "Adolf, what I've been reduced to?" "Kjaer, have a drink!" "No, I'm going to replace my brother." "Guys, let's have a drink." "Take it!" "With Hitler's autograph." "I have my Fuhrer." "Once, a woman?" "Well ..." "Yes." "So That's it." "And she had a mustache?" "No." "You said she's your firer." "That does not necessarily mean that he has a mustache." "Fuhrer has a mustache." "She does not have them." "What is it called?" "Erik." "No lower part?" "No." "Donji Part, bottom part ..." "Here's the bottom part." "Get away!" "Nosi Up!" "What are you thinking?" "Nothing." "Let's ..." "For fallen comrades!" "The Dane has driven me." "They have toilet paper you want." "He gave me a pack of cigarettes." "From Narva remained only a pile of stones." "Dom ..." "Maid ..." "All is forgotten." "Every day I forget something." "This is all I have left from my father." "He received this baptism in the First World War." "In the war for independence is fought against the Reds." "1940, after the June coup he was convicted." "What are we doing here?" "This is not our war." "You bet realms?" "We did not start." "Hitler Attacked Russia." "And when he attacked Finland?" "Who occupied the Baltic states?" "When occupied Poland?" "The devil took them!" "Poland was attacked by both." "You know what happens?" "Red Estonians will return home." "Some return." "There are not many." "A handful." "There are thousands of them!" "It's a Soviet propaganda." "What will you do if you meet Red Estonians?" "His compatriots." "Red Page will be desirable." "Do not you understand?" "There are millions of them!" "It was an avalanche." "The red plague." "You seem not understand anything!" "Calm down!" "Where are you going?" "Yes amen brother." "Let him be quiet." "Shut up!" "Powder, get down!" "Kjaer, your old shift." "What's up here?" "Everything is quiet." "She told me:" "Do not go." "I could not." "Uncle said that that night be arrested in Tallinn." "My message is to inform parents." "I did not believe him." "What arrest?" "Karl, get the gun!" "Get ready, we're leaving." "We are consequently driving." "The trucks are waiting." "Where?" "In Germany." "That's an order." "I'm staying here." "You think you will return from your Siberia if you stay?" "I do not think." "And what do you think?" "Do you know what I saw, such as you?" "They endured a week, a month or two ..." "and that's it." "What is the purpose of residue?" "Will it bring us freedom?" "If what you want Stay here." "19th September." "Operation "Aster"." "The withdrawal of the German army." "Guys do not want to go to Germany." "Melt can go by boat to Sweden." "I have a connection." "Just do not go in Tartu." "Then we're done." "Shut up!" "Do not come home!" "Back!" "That's an order!" "Good day!" "Do you have a Russian ammunition?" "My flee." "Who are you?" "Another troop battalion Virumanskog National militia." "More specifically ... what's left of it." "Guys, let them Spoil!" "Guys ..." "August, Kaupo, Willem ..." "No bullets, This is useful as a button on his shirt." "Heil Hitler!" "Wait a minute!" "And where are you going, the Fair?" "What are you saying?" "Help cho century." "Acting like a cow and not as men." "This is a real firer." "Mom, look!" "Flights!" "Attention!" "Attention!" "Take cover!" "Airplanes!" "Run to the forest!" "Faster!" "Faster!" "Run to the forest!" "Get down!" "Sjajnas, get down!" "Burn up truck!" "You bastards!" "Help!" "Damn!" "Start the truck and pick up the wounded." "Let's quickly in Tallinn." "Red will arrive at any moment." "My sister has the same kind of doll." "It can not have the same kind!" "Why is that?" "This is my Kati." "Of course." "And where is she?" "My sister was away." "No one but her Katie?" "Let's go!" "Help people to fit inside the truck." "Women, children, girls, on the truck." "Scroll." "Wounded to the hospital and refugees in Tallinn." "You may still be able to fetch a boat." "What do I do next?" "Damn life!" "Again I have all I have to solve." "Do you know where my mother is?" "I know." "Kati wants to tell you something." "Kati will explain everything to you later." "Put in Avinurme." "No further." "We'll dig in." "Guys, you know what will become of us?" "Today, the 19th of September, this forest is ours." "Tomorrow, the 20th of September will come Russians and they will drive us out of here." "And the next day, the 21st of September, we will drive the Russians out of the woods." "And the 22 of September there will be a forester and they will drive us all." "Fritz took my daughter to the city" "She went back to her out of there like a whore" "During that time I shed blood on the Eastern Front" "A Adolf deceived us" "A Adolf, bastard, deceived us ..." "It is time for our last dinner!" "Take potatoes CUNKO, bread ..." "It's nice to sit die." "You know who said that?" "No." "Erich Maria Remarque." "What this woman knows about the war?" "This is a man." "He wrote a book "In the West is nothing new."" "It's a shame to get a shot at a full stomach." "Take, guys!" "If you find it a little bit, I'll get more." "Are you guys going to get out of here?" "And where to go?" "Who to leave the cattle?" "Don't Be afraid of the Red?" "Not all to drive in Siberia." "While we are preparing for war, Frico will board a boat and flee." "Tallinn will be released, a brave Estonian will set the tricolor flag on the tallest building and 1,918 years old." "If someone does not trip over." "Do not talk like that." "I thought then:" "What's arrest ... and remained in the city." "When I heard you guys talking about it, I rushed to the train station." "The last train had already left." "I stopped at an intersection and thought." "Perhaps it is better that it was so." "I returned home." "20-September" "Here foresters." "Pig dreams of mud and the sheep of warm water ..." "Hitler dreamed of East where there is a lot of food ..." "The withdrawal of the woods!" "Listen to my command." "Retreating to the print mind !" "Estonians, do not shoot!" "That's an order!" "Do not shoot." "Eight Estonian Corps Soviet Army 249 th Division, 917 th Regiment, n the second battalion, sixth troop" "Why did you let them go?" "When ordered to cease the fire?" "Yeah." "Fascists to be destroyed." "We do not have time to chase every guy shooting at us." "These are not children." "These are the fascists." "Captain Vijres, report to the report." "Rid the capital of Soviet Estonia Tallinn until the 22 September." "That is an order of comrade Stalin." "I'm not ready to go to court martial." "Maybe you are." "We'll see which of the two of us court-martialed." ""The Kremlin" seems no balls." "Jegi I call you in command of the detachment." "Got it!" "Bury killed and hurry to finish before they reach the NKVD." "I'll leave the truck." "And walk in it for us when you're done." "Let's go!" "Yuri, what do we do with these?" "Sahranite Them all." "Guys, what's wrong?" "Bury fascists together with our?" "For them the war is over." "What are you up to, Jurka?" "Do you know how he killed ours?" "His name was Karl Tamika." "It's my countryman." "Did you know him?" "I did not." "Lord have mercy on him and save him." "Let us go then, Jurka." "31 killed a soldier of the Soviet Army" "We heard that you had a fierce fight." "Bravo!" "These savages are getting what they deserve." "Guys, come to eat something." "Do not hesitate." "Where are you from?" "I'm from Sirve." "So far?" "Does it this far?" "Prohor comes from afar." "From Siberia." "His grandmother was Estonka." "Marija." "Yesterday, there were other m OMCI." "Where are they?" "They were sent to another location." "I participated in the war for independence." "Which unit?" "From the Estonian Corps." "Estonskog Corps?" "I did not hear you." "You can not remember all that." "Give the boys smoked meat!" "We have enough meat." "Abram!" "It is immediately obvious." "Germany." "Thank you, Grandma." "How long will all this take?" "Let's go!" "Feel sorry for them." "Why is that?" "I met so taiga hunters." "And they are Raskulacili in camp." "This is my mother." "And this father." "Now he'll show his grandfather ..." "Grandfather." "Uncle Jakob." "Uncle Jakob." "And this?" "It Zara, my sister." "Before the war, in Perm." "Now will you cry." "22-gi September Tallinn" "What are you sad?" "Come on, have a nice trip." "It is not a sin a little fun." "Sergeant Yuri Jegi." "Good evening." "Good evening." "Gradanin A. Tamika live here?" "Yes, that's me." "Aino Tamika." "Then, you ask." "Come on in!" "This is probably for you." "I ran and asked God to all This is not true." "A truck was already standing in the yard." "Mom held at Kadri hands." "She did not cry." "Mom whispered something in his ear." "My father was crazy." "I never saw him like this." "I watched from the bushes when they were completed." "Now you know everything." "Can I help you?" "As this letter has reached to you?" "I am one of those who buried your husband." "Karl is my brother." "I'm not married." "How did he die?" "Died in combat in battle." "How do you know?" "I saw it." "He died before my eyes." "Current death." "Karl was fun, talkative, jolly ..." "When we took a family ..." "In Siberia?" "... Something in him snapped." "It says why." "He thought it was his fault for having happened to mom, father and sister." "And you?" "1939 and invited me to join the army." "In June 1940 I saw when the Red Army arrived." "Why do not you fight?" "We probably were too disciplined and we waited for the order." "Or are we simply scared." "After a few months they themselves did not know how we became Red Army." "Then the war started ..." "What about your family?" "Rudy, however, Oskar, Abram, Prohor ..." "They are my family." "There are less and less." "You're very similar." "With who?" "With my brother." "The innocent feel guilty, and do not feel guilty." "Probably you are hungry?" "This is my uncle's house." "They escaped by boat to Sweden two weeks ago." "The Soviet Army, 9th March ..." "And they told us that they are The Germans did." "In the city there were only women, children and the elderly." "The men were at the front." "Most sorry children." "With us they brought a sympathy icnu girl." "I work there as a teacher." "She drew a funny sketch." "I'll show you." "Where it has gotten lost?" "It's open." "Are you staying here long?" "Or are you going next?" "Where?" "They tell us to go to the island Sarima." "We're alone here." "I think I forgave him." "Who?" "One who betrayed our family." "Someone from the family Jegi." "My brother wrote." "What is it?" "I remembered how good we are lived before the war." "Yuri, I do not know your last name." "Tul." "Juri Tul." "Comrade Jegi, come with me!" "Good day, Comrade Captain." "Together we went through the war." "From large meadow to Tallinn." "In our ranks there are still nationalists and enemies of the people." "And I know it." "You're young, energetic ..." "All have arrived." "Even a walk around the city at night." "Who is she?" "Who?" "She boulevard with Estonia." "My sister." "I visited my sister." "I looked at your file." "There is no reference to a sister." "I probably did not read carefully." "I think that we agreed." "Obaveštavaceš me as soon as you notice and the smallest anti-Soviet facts from ordinary soldier to the highest officers." "You can go!" "17th November Saremaa" "Prohor, leave!" "Less out of the barn!" "But he returned." "The boy returned home." "Here is born." "He came straight home." "My grandmother used to say that the country is small, but it's just so small ..." "Juri, go with it!" "Well, hosts, saves j bathroom, prepare food ..." "Not a soul." "And barn is empty." "Immediately'll look for something to eat." "She arrived filling." "Three of the soldiers." "Wait in front of the door." "Let them come." "Got it!" "Comrade Senior Sergeant, let go!" "I am your commander, Yuri Jegi." "Dismissed!" "Admit when you served in the German army?" "I fought in Sinimaea." "I ran home when the Germans began to retreat." "There we were captured by the Russians." "And me too." "I deserted." "Forget the past." "There will survive Only the one who knows how to keep his mouth shut." "Is that clear?" "Of Course!" "But!" "Tul Red Army!" "But where have you gone?" "Pekala The guys potatoes." "Feed them, Hungry." "Eat As you like." "The basement has a potato you want." "Do not leave anything rats." "But!" "Did you find out something about your family?" "All farms in Sirvaste are destroyed." "The people taken to Germany." "The war will end quickly." "All will return." "My house was intact, and I'm alive." "Here, on this farm, We will be attacking Fritz." "Before us, this place will shoot our artillery." "Frico are here set minefield." "We will pass through here in our tanks." "And why do we go forward?" "Komandir Troops wants to go first." "Frico have prepared ships on the coast." "You must destroy them." "Where is our invincible Red Fleet?" "Cesa Eggs in Kronstadt." "Stalin 100 grams." "Let's drink!" "Hell, Juri, completely forgot." ""The Kremlin" and called." "Yes!" "Sergeant Yuri Jegi the appears on your orders." "Close the door!" "Sit down!" "To victory!" "Did you arrived filling?" "Yes." "Three." "Have you checked?" "I did." "You're a good family." "You always make the right decisions." "As your father in his time." "You're still not a party member?" "I did not." "Maybe it's better that way." "Ulivaš confidence." "Far you have gone." "I'll send you to the course." "You'll get a star." "You will become a company commander." "Well we get along." "We already have a company commander." "Captain Vijres." "Daikon." "Outside red, inside white." "Such as Vijres be good to watch." "Do not spoil your life, Juri." "19-November" "The last line of defense of the German Army on the peninsula Sirve" "The minefield is on both sides!" "Get behind the tanks!" "Get up and go for a tank!" "Come on, move on!" "Do not go there!" "There is a minefield!" "Take cover behind a stone wall!" "Prohor!" "Oskar!" "Abram, Kjaer, for me!" "Prohor, Abram, for me!" "Oskar, for Ali!" "But ..." "Get out!" "With your hands up!" "Get out!" "With your hands up!" "You think it will return Sara?" "What is it?" "Not sleeping?" "I can not forget this guy." "I took his last letter ..." "his sister." "Jes tell her the truth?" "You could not?" "So you're in a bad mood?" "Do not worry, Jurka." "You did not kill her." "He was killed by war." "God will forgive you." "It will help you and goodbye." "22-gi November." "Just a little more and Estonia is ours." "Come on, let's go!" "Yuri, the Political Department interested in you." "We're in shit up to his neck." "We will not wait for old age." "I just wanted to bring the boys back home, and where I have to bring?" "Stop!" "Hooks up!" "Do not shoot, we are Estonians!" "Silence!" "Do not shoot!" "Get out!" "With your hands up." "Easy!" "Name?" "Hard Hirv." "How old are you?" "16." "Volunteer?" "No." "The Germans picked us up." "At the airport." "They wanted to send us to Germany and we wanted the house." "Juri, get your people!" "Fire at enemies." "Comrade Captain ..." "These are children." "Soviet citizens who cross on the side of the enemy are punishable by firing squad on the spot." "Sergeant Major Jegi, complete the order!" "Mobilisali Them." "Juri, fulfill orders!" "I can not shoot them." "Shoot!" "Shoot, and all your will end up in the camp." "You're afraid of?" "Right." "Soviet authorities feared." "Captain Vijres, complete the order!" "Another platoon, forward!" "Guys, go home!" "Have you heard?" "Take off your uniforms and go home." "One thought does not give me peace." "What if you did not bring this letter?" "Would you happen to be met?" "After the war." "Maybe even in the church." "Good afternoon." "Good afternoon." "A live here, Tamika?" "Yes, I'm Aino Tamika." "Then, you ask." "Good day!" "Come in." "Who knows, maybe we'll meet again." "How did you sleep?" "Good." "If I could look into her eyes, I have to tell the truth." "It should start from the beginning." "It says it Juri Jegi, soldier of the Soviet Army who was killed in fighting your brother." "I did not have the courage to I tell you this in person." "Now I have only you in the world." "Forgive me if you can ..." "Dedicated to all those who fought and died for independence" "Slavorkc-Keresturi 02.05.2015."

Each advance in electronic components can cause increases in heat generation in a smaller package size. Due to these factors, there is a need for dissipation of the heat generated by these components. For example, there is a current need to dissipate heat from personal computer Central Processing Units (CPUs) in the range of 50 to 150 W. Forced and natural convection air cooling methods, used in conjunction with heat sinks and heat pipes, currently serve as the predominant method of cooling electronics. The current conventional air cooling systems that use aluminum extruded or die-casting fin heat sinks are not sufficient for cooling the high heat flux of chip-surfaces or for large heat dissipation with low thermal resistance and compact size. Further, these air-cooled heat sinks require a substantial surface area to effectively function. To be able to transfer the increased heat load, the air-cooled heat sinks have become even larger. This requires the use of larger fans to overcome back-pressures caused by the large heat sinks. In other words, current air-cooled heat sinks require substantial space on the one hand, while blocking airflow entry and escape paths on the other. Thus, current cooling methods are unequal to the task of removing heat. Moreover, the use of progressively larger fans increases the amount of acoustic noise generated by the cooling system and also increases the amount of electric power drawn by the system. For example, conventional solutions include use of multiple heat pipes to carry the heat to large heat sinks via high airflow. This leads to solution with high noise levels, which are undesirable. Furthermore, a shortcoming of current traditional fan based heat dissipation methods is that heat is transferred in only one direction because a fan is placed to blow air in one direction over the heat sink. This limitation causes non-uniform temperature gradients across the heat sink and correspondingly, across the electronic component. Due to these factors, and other shortcomings, there is a need for a more efficient and effective cooling system.

Trends in the pathophysiology and pharmacotherapy of spasticity. Spasticity develops after supraspinal or spinal lesions of descending motor systems, with obligate involvement of the corticospinal tract. Spasticity is characterized by an increase in muscle tone, which, in contrast to many other types of enhanced muscle tone, shows a marked velocity-dependent increase when the muscle is passively stretched. The pathophysiological mechanisms underlying this spastic muscle tone remain obscure. Three major causes are currently considered possible: (1) changes in the excitability of spinal interneurones; (2) receptor hypersensitivity; (3) formation of new synapses by sprouting. The latter mechanism could account for the long time course over which spastic muscle tone develops in hemiplegic or paraplegic patients, but there is no experimental evidence for this hypothesis. The electromyographic (EMG) gait analysis of patients with spasticity has thrown doubt on the common belief that the velocity-dependent increase in spastic muscle tone is evoked by stretch reflex activity and has led to the idea that spastic muscle tone resides in the muscle fibres themselves. While such a mechanism may contribute to the slowness of active movements in spastic patients, recent experiments on patients with spastic arm paresis have confirmed the classical view that the spastic muscle tone is related to the EMG activity evoked in the passively stretched muscle. This pathological EMG activity is seen during the entire range of the dynamic phase of the stretch, during which a normal muscle exhibits only an early, phasic burst at the highest stretch velocities employed. For the pharmacological treatment of spasticity, substances with different central or peripheral actions are available. Their assumed receptor actions are described, together with their main indications and side-effects.(ABSTRACT TRUNCATED AT 250 WORDS)

This section is intended to provide a background or context to the invention recited in the claims. The description herein may include concepts that could be pursued, but are not necessarily ones that have been previously conceived or pursued. Therefore, unless otherwise indicated herein, what is described in this section is not prior art to the description and claims in this application and is not admitted to be prior art by inclusion in this section. Understanding nanoscale processes is key to improving the performance of advanced technologies, such as batteries, catalysts, and fuel cells. However, many processes occur inside devices at short length and time scales in reactive environments and represent a significant imaging challenge. One way to study such structures is by using coherent diffraction imaging (CDI). CDI is a lensless technique for reconstructing a 3D image of an object based on a diffraction pattern. In CDI, a coherent beam of x-rays or electrons is incident on an object, the beam scattered by the object produces a diffraction pattern that is measured by an area detector, and an image is reconstructed from the diffraction pattern. When the diffraction pattern is measured by the area detector, the data is based on a number of counts of photons or electrons. This gives rise to the “phase problem” or loss of phase information when a diffraction pattern is collected. In order to recover the phase information, Fourier-based iterative phase retrieval algorithms are utilized. Another example of CDI is Bragg coherent diffractive imaging (BCDI). In BCDI, the object is rotated around a tilt axis and a sequence of 2D diffraction patterns are measured at different sample orientations. BCDI is a powerful technique for investigating dynamic nanoscale processes in nanoparticles immersed in reactive, realistic environments. With current BCDI methods, 3D image reconstructions of nanoscale crystals have been used to identify and track dislocations image cathode lattice strain during battery operation, indicate the presence of surface adsorbates, and reveal twin domains. The temporal resolution of current BCDI experiments, however, is limited by the oversampling requirements for current phase retrieval algorithms. Conventional phase retrieval algorithms present a problem in improving the time resolution of an imaging technique (e.g., CDI, BCDI, etc.). The imaging technique requires a computer algorithm to convert the experimental data into a real space image of the object (e.g., nanocrystals) in reactive environments. Oversampling refers to the number of measurements that are required to faithfully reproduce the image. The autocorrelation of the image must be sampled at the Nyquist frequency, which is twice the highest frequency in the system. Because each measurement takes time, the oversampling requirement results in a lengthy process that may include prolonged radiation dose. Moreover, if the oversampling requirement is too high, it may not be possible to image a dynamic process such as crystal growth, catalysis or strain in battery cathode nanoparticles that occur too rapidly (i.e., faster than the amount of time it takes to satisfy the oversampling requirements). A need exists for improved technology, including a method for phase retrieval that allows for the time resolution to be improved, for example, by reducing the oversampling requirement at each time step.

A survey of Hwa-Byung in middle-age Korean women. Hwa-Byung (HB) has been categorized as a Korean culture-bound syndrome that refers to insidious, long-standing, serious discontent that is projected into the body and is manifested by numerous symptoms such as insomnia, fatigue, panic, palpitations, dyspnea, and others. This study was designed to investigate the prevalence rate of HB in Korean women, validate the predominant symptoms of HB, and validate the related sociodemographic factors and lifestyle factors that differentiate women with HB from those without HB. A total of 2,807 women ages 41 to 65 years were recruited from seven metropolitan areas and six provinces in Korea. The prevalence rate of women who designated themselves as having experienced HB was 4.95%. The rates were higher in women of low socioeconomic status, living in rural areas, among the divorced or separated, smokers, and drinkers. A set of 31 HB symptoms differentiated the potential HB women from the non-HB women.

Incidence and prevalence of HIV encephalopathy in children with HIV infection receiving highly active anti-retroviral therapy (HAART). To describe neurologic outcomes in children infected with HIV in the era of highly active anti-retroviral therapy (HAART), including rates of progressive HIV encephalopathy (PHE) and clinical sequelae among PHE survivors. Neurobehavior and school placement was assessed prospectively in the year 2000 in 126 children infected with HIV. PHE, developmental delay, and attention deficit disorder (ADHD) were the main outcome variables analyzed. Predictors of PHE were assessed in controlled analysis among age-matched controls. The rate of active PHE in 2000 was 1.6% (n = 2), and the prevalence of arrested PHE was 10% (n = 13). Residual motor and cognitive sequelae and need for special education was found in the majority of survivors. PHE relapse occurred in 3 (23%) children with previously arrested PHE. Viral load (VL) was the only significant factor associated with PHE. HIV or PHE was not associated with ADHD. Isolated developmental delay was not associated with HIV. PHE is an infrequent and reversible complication of HIV infection that responds to HAART and that may relapse if control of the virus is lost. Children with arrested PHE show higher rates of residual neurologic, cognitive, and scholastic impairments compared with children who never had PHE. Children with arrested PHE are the group of children with HIV infection most at risk for PHE, in the form of a relapse.

[Comparison of measuring energy expenditure with indirect calorimetry and traditional estimation of energy expenditure in patients in intensive care unit]. To compare measurement of energy expenditure (MEE) by indirect calorimetry (IC) with traditional estimation of energy expenditure (EEE), to provide a basis for energy supplementary for critically ill patients. Using self-controlled study,the energy expenditure of 57 intensive care unit (ICU) patients was measured by IC. Meanwhile, EEE was also calculated using the following equations : Harris-Benedict (HB), HB×factor , or 104.6 kJ/kg. Body weight were calculated using actual body weight (ABW) or ideal body weight (IBW). If body mass index (BMI)<18.4 kg/m(2) it was considered as underweight , and the IBW was selected from the IBW table. The potential adequacy of estimated energy was assayed by ratio of EEE/MEE. There was significant difference in MEE by IC and EEE by HB, HB×factor and 104.6 kJ/kg [(6 335 ± 1 004) kJ, (9 125 ± 1 795) kJ, (7 188 ± 1 029) kJ vs. (7 753 ± 1 439) kJ ,P<0.05 or P<0.01]. There was significant difference between EEE by HB×factor and 104.6 kJ/kg (P<0.01) , and EEE by 104.6 kJ/kg×ABW , and the latter was closer to MEE. Underfeeding would occur in most ICU patients if HB equation was used [100% (4/4) in underweight patients and 73.59% (39/53) in normal weight (BMI 18.5-23.9 kg/m(2))]. EEE as calculated by 104.6 kJ/kg×IBW was reasonable in the underweight patients 100% ( 4/4 ), but EEE in the patients with normal weight by using HB×factor or 104.6 kJ/kg×ABW resulted in significant underfeeding [39.62% (21/53) and 43.39% (23/53)] or overfeeding [24.53% (13/53) and 13.22% (7/53)]. EEE derived from the equations was extremely inaccurate and may result in significant underfeeding or overfeeding in individuals. On the basis of this study we would recommend IC for measuring energy expenditure in ICU patients. Otherwise , the equations of 104.6 kJ/kg×IBW in underweight and 104.6 kJ/kg×ABW in normal weight patients may be reasonable.

In many gas turbine engines, a low pressure spool includes a low pressure turbine that is connected to and drives a low pressure compressor, and a high pressure spool includes a high pressure turbine that is connected to and drives a high pressure compressor. Air is compressed by the compressors and communicated to a combustor section where air is mixed with fuel and ignited to generate a high pressure exhaust gas stream that expands through the turbines. Energy is extracted from the turbines to drive the compressors. The spools are mounted for rotation about an engine central longitudinal axis relative to an engine static structure via several bearing systems. The bearing systems are located within bearing compartments that include heat shields to protect components from the high temperatures of the exhaust gases. The heat shields are typically comprised of sheet metal plates that are attached to the engine static structure with bolts. Due to the thinness of the plates, the bolts can potentially damage areas of the heat shield that come into contact with the head of the bolt during installation. This increases maintenance costs as the shields have to be replaced during overhaul service operations. Riveted-on nut plates are not preferred in hot sections of the engine because threads can seize and pull apart anti-rotation features on the plates requiring them to be drilled out. Another proposed solution is to use thicker mount flanges that are welded to the shields; however, this increases cost and weight.

1. Field of the Invention The present invention relates to devices and methods for preserving portable, flexible receptacles, such as a handbags, gloves, shoes, etc., and in particular, to preserving their shape and reducing deleterious moisture in them. 2. Description of Related Art Handbags, slippers, gloves, shoes and other articles are often made of delicate, rare, or relatively expensive materials. Also, some articles are highly prized because of the prestige of its brand, their distinctiveness as an antique, a limited production volume, or other economic or social factors. Owners of such goods will very much want to preserve them from damage. Taking handbags as an example, that market has experienced tremendous growth recently. The U.S. market alone is projected to reach $9 billion by 2015 and the market only appears to be poised for more growth, with the luxury segment of the market leading the way. Handbags are often treated less like a purchase and more like an investment. Accordingly, many purchasers go to great lengths to protect and preserve their handbags. To date, most of the focus has been on preserving the outside of the handbag. In fact, it is commonplace for handbags (particularly, the more expensive handbags) to be sold with a dust bag in which the bag is to be kept in order to protect it from outside elements. Handbags and other articles are often shipped with inserts for preserving their shape. Unless such initial precautions are taken, the article might partially collapse or develop ripples or wrinkles due to gravity-induced settling or from being stacked together with other articles during shipment or storage. When an insert is used, the article will have crisp and new appearance when first removed from a shipping container. Also, the insert will maintain the article's appearance if it is put on display. After purchase, a consumer usually discards the insert. Consequently, over time, the article tends to change shape and lose its crisp, new appearance. Even if the consumer were to keep the insert and use it when storing the article, the insert would not last long since it is typically made of nondurable materials such as cardboard, thin plastic, or crumpled tissue paper. Some articles such as handbags are in the form of receptacles with an internal space in which moisture can be a problem. In such cases, keeping moisture under control is important to suppress mildew, mold, rust, etc. For this reason, many articles are shipped with a packet containing a desiccating agent for reducing moisture that might otherwise damage an article made with easily degraded materials such as leather, cloth, steel, etc. To keep the desiccating packet effective, the shipping container is sealed to reduce infiltration of moist air. In some cases the article is placed in a box that is sealed with durable packing tape. Alternatively, the article may be sealed in a separate plastic bag placed in a larger box. Under these circumstances, a relatively small desiccating packet may be adequate to dry a fixed, noncirculating volume of air during shipment. After being removed from its shipping container, the desiccating packet is often discarded and its advantage lost. The problem with internal moisture may then arise, especially since receptacles such as a handbag, will normally be kept closed to avoid forming wrinkles. Even if the desiccating packet were retained and placed inside a closed article such as a closed handbag, the packet will be inadequate because moisture will ordinarily infiltrate and replace the dry air unless the handbag is nearly airtight, which is almost never the case. In addition, the packets that are usually included tend to be very small and of limited capacity; thus, losing their effectiveness fairly quickly Aftermarket products for maintaining the shape of an article are limited and have been bulky and inconvenient. They require a user to squeeze and manipulate a resilient material in order to insert it into the article as well as to remove it. Such manipulation of the insert is also likely to damage the handbag. Moreover, providing an aftermarket device for preserving previously purchased articles such as a handbag, is hindered by the enormous diversity in the shapes and sizes of such articles. See also U.S. Pat. Nos. 3,131,036; 4,565,287; 4,813,791; 5,291,669; 5,542,191; 5,934,808; 5,950,323; 6,378,224; 6,769,807; 7,108,425; 7,699,913; 7,770,723; and 7,930,837, as well as US Patent Application Publication No. 2011/0061257.

Selection and mapping of replication origins from a 500-kb region of the human X chromosome and their relationship to gene expression. In higher eukaryotes the mechanism controlling initiation of DNA replication remains largely unknown. New technologies are needed to shed light on how DNA replication initiates along the genome in specific regions. To identify the human DNA sequence requirements for initiation of replication, we developed a new method that allows selection of replication origins starting from large genomic regions of human DNA. We repeatedly isolated 15 new putative replication origins (PROs) from a human DNA region of 500 kb in which 17 genes have previously been characterized. Fine-mapping of these PROs showed that DNA replication can initiate at many specific points along actively transcribed DNA in the cell lines used for our selection. In conclusion, in this paper we describe a new method to identify PROs that suggests that the availability of initiation sites is dependent on the transcriptional state of the DNA.

Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration. In performing host-defense functions, cells of the immune system become activated by soluble chemokine signals and must migrate through endothelial cell or solid tissue barriers to reach sites of inflammation or infection. Regulated adhesive interactions of immune cells with endothelium, extracellular matrix components, and cells of solid organs are critical control points of the overall immune response. Both the soluble chemokine and cell adhesion receptor-mediated migration signals must converge on common intracellular targets to engage the cell migration machinery. In this article, we focus on the role of focal adhesion kinase (FAK) and its homolog Pyk2 as cytoplasmic mediators of motility events in multiple cell types. We introduce the overall domain structure of the FAK and Pyk2 nonreceptor protein tyrosine kinases (PTKs), highlight some of the signals that activate these PTKs, and detail the molecules that functionally interact and signal transduction pathways that may mediate cell migration responses. Emphasis is placed on the knowledge gained from studies using FAK-null cells as a model system to decipher the role of this PTK in promoting cell motility.

1. Field of the Invention The present invention relates to a filtration apparatus that filters liquids such as water. 2. Description of the Related Art Conventional water purification processes at large scale water treatment plants involve adding chemicals to untreated water drawn from rivers, lakes, ponds, or wells to consolidate the suspended matter therein to a size that causes said consolidated matter to deposit on the bottom. The supernatant water is skimmed and sent to a filtration reservoir, where it is passed through filtration media such as filtration sand to remove the finer suspended matter. This water is then disinfected with chlorine. However, if water is filtered utilizing filtration media in this manner over a long period of time, the filtering efficiency decreases due to the pollutants in the water (contaminants such as sludge, hereinafter referred to as contaminants) attaching to the filtration media, among other reasons. Therefore, it becomes necessary to periodically cleanse the filtration media. As cleansing methods of filtration media, surface cleaning, which washes the surface of a sand layer by hitting it with water sprayed from a nozzle, and backwash, which forces purified water into a filtration reservoir from a lower pressure compartment, thereby floating the filtration sand grains, causing them to scrub against each other, were in common use. However, the surface cleaning and backwash methods described above utilize the effects of stream shear, and cannot cleanse the filtration media with satisfactory efficacy. Problems arise from repeated use over a period of time such as: the reduction of space among the filtration media due to the progressive thickening of particle size from contaminant accumulation thereon, clogging due to the separation of materials that had been attached to the filtration media, and the leaking of the contaminants themselves. Conventionally these problems were dealt with by, for example, increasing the frequency of the backwash process. However, if the backwash process is repeated over a long period of time, the water pressure thereof influences even the gravel layer which supports the filtration media, creating areas of different thickness in said layer, which is optimally flat and of an even thickness. In this case, it is necessary to perform a regeneration process, which involves: ceasing the total operation of the filtration reservoir, removing the filtration media, correcting the discontinuities in thickness of the gravel layer), replacing the filtration media with new filtration media, or with the polluted filtration media which has been cleansed. However, the regeneration process is extremely costly, and as during said process the filtration reservoir is not operating, it leads to a decrease in water treatment efficiency, there is a strong demand on the part of the water treatment plant to space the intervals between regeneration processes as long as possible. The applicant of the present invention, in order to meet this demand, has developed and proposed a sand cleansing apparatus which cleanses polluted filtration media in a shorter time and with a higher degree of cleansing ability (Japanese Unexamined Patent Publication Nos. 10(1998)-109051 and 11(1999)-057526), which has been utilized and praised by those in the field. This sand cleansing apparatus comprises: a sand receiving opening for receiving filtration media drawn from a filtration reservoir in its upper portion; a cleansing tank which stores sand and cleansing water having a sand extraction opening; a agitating tank erected within said cleansing tank having openings on the upper and lower ends thereof; and a screw conveyor which rotates within said agitating tank. The grains of sand are brought upward by the screw conveyor along with the cleansing water. As they are being conveyed upward, said grains of sand rub against each other, and the scrubbing action thereof effectively removes the contaminants that are attached or coated thereon. As opposed to a large scale water treatment plant as has been described above, filtration systems such as those installed in the filtration tanks of small scale simple plumbing or factories have within a container a filtration tank which holds the filtration media as well as the water to be purified by said filtration media. These filtration systems are structured to expel the water that has been purified by said filtration media from the filtration tank through a filtration floor to the outside of the container. It is common practice to utilize the surface washing or backwash methods for the filtration media of these filtration systems, and they have similar problems as those of the filtration reservoir; that is, the consumption of a large amount of purified water in the backwash process, and that the cleansing effectiveness is insufficient. Further, as the filtration media in a filtration system is housed within a small container, the contamination thereof progresses at a higher rate than that of a filtration reservoir. Still further, as they perform high-speed filtration, contaminants are more likely to leak, so it can be said that said filtration media is operated under harsher conditions than that of a filtration reservoir. Therefore, it is necessary to replace or regenerate said filtration media on a shorter cycle. It is conceivable to utilize the above-described sand cleansing apparatus by the present applicant (Japanese Unexamined Patent Publication Nos. 10(1998)-109051 and 11(1999)-057526) to cleanse the filtration media drawn from the filtration systems. However, compared to the amount of filtration media in a filtration reservoir, the amount of filtration media in a filtration system is extremely small, and the operational scale of same is also small. Therefore, it is inefficient and impractical to secure the space required to install the above-described sand cleansing apparatus, as well as expending costs for its installation and removal, to cleanse such a small amount of filtration media. As a practical matter, it is generally the case that the filtration media is replaced with new filtration media, as opposed to being reused after cleansing. However, the filtration media to be disposed after being replaced must be dealt with as industrial waste, and the cost of such disposal is high. It is also preferable from an ecological viewpoint to switch from the easy trend of consume-then-dispose to a direction in which resources are recycled and reused. In view of these points, there are known filtration apparatuses which have a filtration media cleansing mechanism provided within the filtration tank, such as the filtration devices disclosed in Japanese Patent No. 31491 and Japanese Utility Model Publication No. 63(1988)-98704. In the former filtration device, a central pipe is suspended from above a filtration compartment and positioned so that a lower opening of said pipe communicates with the interior of said compartment. Within the upper portion of the central pipe is provided a propulsion device in the form of a propeller. Higher still than said propulsion device is disposed a tube having a spray opening slightly above the central pipe, facing a lateral side thereof. The tube is linked to the propulsion device so that it rotates therewith, and sprays cleansing fluid at high speed from its spray opening by centrifugal force. To cleanse the filtration media, the propulsion device is rotated, thereby drawing the filtration sand into the central pipe through its lower opening. The filtration sand that has been propelled upward is expelled to the side of the central pipe by the cleansing fluid discharged from the spray opening of the tube. By this, the filtration sand is cleansed by the separation of the contaminants therefrom. As to the latter filtration device, a pump pipe is suspended from above a tank so that it is positioned therein, and within this pipe is provided a rotatable spiral water pump. This filtration device is configured to perform a normal filtration operation by discharging untreated water into the filtration sand by an untreated water distribution tube placed within the filtration sand. This water travels upward through the filtration sand, is filtered thereby, and the resultant processed water is expelled from above said filtration sand. This filtration device is further configured to perform a cleansing operation by rotating the spiral water pump, raising the filtration sand which has acquired contaminants thereon, separating the contaminants from the filtration sand by the centrifugal separation phenomenon, and the resultant cleansed filtration sand is excelled through a filtration sand expulsion opening provided in the upper portion of the pump pipe. Further, in the former filtration device, a normal filtration operation is performed by filtering untreated water provided from above through filtration sand placed on an apertured false bottom. The central pipe in this device has an open bottom; therefore it is always in the state that filtration sand is inside said pipe. However, the device is not constructed so that water flows into said central pipe and aggressively filtered therethrough. Further, to perform the cleansing operation, it is necessary to rotate the propulsion device at a rather high speed in order to draw up the filtration sand; therefore there is a fear that the filtration sand will be crushed upon impact with the propulsion device. As to the latter filtration device, as it is of a upward flow type, that is, the filtration is performed by directing the stream of water from beneath the filtration sand upward, if the filtration speed is increased, the small grains of filtration sand are caused to float, increasing the space between said grains of filtration sand. As a result, contaminants, especially small particles thereof are insufficiently filtered, thereby decreasing the filtering performance. Also, when performing a cleansing operation, as a spiral water pump (screw) is rotated at high speed, the cleansing effect is low, and there is a fear that the filtration sand will be crushed upon impact with the spiral water pump as it rotates at high speed. The present invention has been made in view of the above-described circumstances, and it is an object of the present invention to provide a filtration apparatus possessing both a high filtration performance property and a high cleansing performance property. Another object of the present invention is to provide a filtration apparatus that effectively cleanses filtration media without requiring the installation and removal of a cleansing apparatus each time that filtration media is to be cleansed. The filtration apparatus of the present invention has a filtration media cleansing mechanism installed within the filtration tank. By utilizing said mechanism to cleanse the filtration media in the filtration apparatus, obviates the need to provide a specific space for a separate cleansing apparatus, as well as the need to install and remove such apparatus, while cleansing said filtration media in a short amount of time with a sufficiently high degree of cleansing. The filtration apparatus of the present invention comprises: a container that houses a filtration tank which holds therein filtration media as well as the liquid to be filtered by said media; a filtration media cleansing mechanism having a hollow cleansing tank for cleansing the filtration media inside the filtration tank; wherein said filtration media cleansing mechanism is provided with a contaminant expulsion means for expelling the contaminants that have been separated from the filtration media to the outside of the container and also expels the liquid that has been purified by the filtration media to the outside of the container. Said cleansing tank is a hollow body erected within said filtration tank; has lower openings that are closed during a filtering operation and opened during a cleansing operation; has an upper opening at a level at least higher than the upper surface of the filtration media in the filtration tank; has provided therein a screw conveyor which conveys the filtration media as well as the liquid which flows into the cleansing tank upwards from the lower openings to the upper opening thereof while scrubbing said filtration media and said fluid. The rotation of said screw conveyor conveys the filtration media upwards, and discharges said media as well as the contaminants separated therefrom by the scrubbing action from the upper opening into the filtration tank. Here, the liquid to be poured into the container is generally water to be purified by filtration, but it is not limited to this. For instance, waste oil of cutting lubricant may be used. Further, when water is used as the liquid, it is preferable to utilize filtration sand as the filtration media, but it is not limited to this. Many different materials may be used as the filtration media. As the filtration media and the liquid is conveyed upwards by the screw conveyor, the filtration media is fluidized, the grains of the filtration media rub against each other, and the scrubbing action thereof effectively removes the contaminants that are attached or coated thereon. The contaminants removed in this manner floats in the liquid being conveyed upward, is discharged into the filtration tank from the upper opening of the cleansing tank, and is expelled outside the container by the contaminant expulsion means. As the contaminant expulsion means, it is preferable to utilize a backwash mechanism that discharges filtered or clean liquid during a state when the lower openings of the cleansing tank are closed by the opening/closing means. The discharge of liquid by said backwash mechanism causes the contaminants, which are floating in the liquid surface layer within the filtration tank to be expelled through an overflow expulsion means. It is possible to effectively expel the contaminants, which have been separated from the filtration media, that remaining the filtration tank by utilizing the backwash mechanism equipped on the filtration apparatus to cleanse the filtration media therein. Further, if the filtration media cleansing mechanism is of the type that does not have a water retention means to retain the liquid that has been poured into the container within the filtration tank, it is preferable to provide a retention means with a water retaining function. This is because it is possible to perform efficient cleansing utilizing only the retained water. With regard to the filtration apparatus of the present invention, it is preferable to provide a switching mechanism for switching between the operations of xe2x80x9ccleansingxe2x80x9d by the filtration media cleansing mechanism and xe2x80x9cfilteringxe2x80x9d of liquids. This is because it is possible to efficiently perform each of these operations by switching the switching mechanism to xe2x80x9cfilteringxe2x80x9d when filtration of the liquid is to be performed, which precludes xe2x80x9ccleansingxe2x80x9d from being performed, and by switching the switching mechanism to xe2x80x9ccleansingxe2x80x9d when cleansing is to be performed, which precludes filtration from being performed. As to the switching mechanism, it is preferable to utilize one that is equipped with a door that is of a sufficient size to close the lower openings of the cleansing tank and an opening/closing means for opening and closing same. This is because by the opening and closing operation of said door, it is possible to allow the filtration media and liquid to flow into the cleansing tank during a cleansing operation, and to positively prevent the filtration media from flowing into the cleansing tank during a filtration operation, thereby positively switching between the two operations (filtration and cleansing). Further, the screw conveyor and the lower and upper openings formed in the cleansing tank combine to provide the effect that the filtration media within the filtration tank progressively circulate within the filtration tank and the cleansing tank. This circulation makes thorough cleansing of the filtration media possible in a short time. It is preferable to utilize a door, which is movable along an outer or inner periphery of the outer wall of the cleansing tank. This is to reduce the resistance of the filtration media accumulated within the filtration tank during an opening/closing operation. Similarly, it is also preferable to utilize a structure for the opening/closing means that easily overcomes the resistance of the filtration media. For example, a structure may be utilized such that a worm wheel is fixed on the outer peripheral surface of the door, and a motor or the like rotates the worm that engages said worm wheel. By this structure, the rotation of the worm scrapes out the filtration media, which had entered the spaces between the teeth of the worm wheel, and the resistance of the filtration media can be reduced during an opening/closing operation. Note that of the filtration apparatus of the present invention, the filtration media cleansing mechanism and the switching mechanism that switches between xe2x80x9ccleansingxe2x80x9d of the filtration media by the cleansing mechanism and xe2x80x9cfilteringxe2x80x9d as necessary provided in the filtration tank of the filtration apparatus, can be provided as an after market cleansing apparatus. By this, it becomes possible to customize an existing filtering apparatus to a filtering apparatus of the present invention, having the function of cleansing the filtration media, thereby controlling the installation cost. Further, the filtration apparatus of the present invention comprises: a container that houses a filtration tank which holds therein filtration media as well as the liquid to be filtered by said media; a filtration media cleansing mechanism having a hollow cleansing tank for cleansing the filtration media inside the filtration tank, wherein said mechanism is provided with a contaminant expulsion means for expelling the contaminants that have been separated from the filtration media to the outside of the container; and a means for expelling the liquid that has been purified by the filtration media to the outside of the container. Said cleansing tank is a hollow body erected within said filtration tank; has lower openings that are open at all times; has an upper opening at a level at least higher than the upper surface of the filtration media in the filtration tank; has a plurality of lateral surface openings that extend in a vertical direction on a lateral surface thereof; said lateral surface openings having lateral surface doors opened and closed by a plurality of drive means. Said cleansing tank further has filtration media housed therein at all times; has provided therein a screw conveyor which conveys the filtration media as well as the liquid which flows into the cleansing tank upwards from the lower to the upper opening thereof while scrubbing said filtration media and said fluid. The rotation of said screw conveyor conveys the filtration media upwards, and discharges said media as well as the contaminants separated therefrom by the scrubbing action from the upper opening into the filtration tank. With regard to the contaminant expulsion means, it may be of the type that utilizes a backwash mechanism. The backwash mechanism discharges filtered or clean water from the filtration floor into the filtration tank to float the filtration media during a closing operation of the lateral surface doors, performed in order for the screw conveyor to agitate the filtration media. Further, during rotation of the screw conveyor, it is preferable that the lateral surface doors are closed. The backwash mechanism of the contaminant expulsion means is structured to discharge filtered or clean liquid from the filtration floor into the filtration tank during an opening operation of the lateral surface doors, performed when the agitating operation is completed. Further, the contaminant expulsion means can be equipped with an overflow expulsion means that expels the contaminants caused to float in the liquid surface layer by the discharge of liquid by said backwash mechanism within the filtration tank to be expelled therethrough. The filtration media cleansing mechanism can also be equipped with a retention means for retaining the liquid poured into the filtration tank therein. When the filtration tank is filled with liquid, the liquid becomes pressurized. It is also possible to filter said pressurized liquid through the cleansing tank, as the filtration media is housed in the cleansing tank at all times. The filtration apparatus of the present invention is equipped with a backwash mechanism that discharges filtered or clean liquid into the filtration tank through the filtration floor. During a cleansing operation, it is preferable that the lateral surface doors be closed after the filtration media is caused to be in a suspended state by said backwash mechanism. Further, the contaminant expulsion means described above can be configured to expel the contaminants caused to float in the surface layer of the liquid by the discharge of filtered or clean liquid by the backwash mechanism after the agitating operation is complete and the lateral surface doors are opened. Still further, the filtration media cleansing mechanism may be equipped with a retention means for retaining the liquid poured into the container. The agitating, scrubbing, and expelling operations may be performed using solely said retained liquid. According to the filtration apparatus of the present invention, the cleansing tank is a hollow body having a plurality of lower openings, which are closed during a filtering operation and opened during a cleansing operation of filtration media as well as an upper opening that is positioned above the upper surface of the filtration media within this cleansing tank is equipped a screw conveyor that conveys the filtration media as well as the liquid upward through said tank from the lower openings to the upper opening thereof, while scrubbing the filtration media. As the cleansing tank is structured so that the rotation of the screw conveyor conveys the filtration media upward while scrubbing same, and said filtration media along with the contaminants separated therefrom are discharged into the filtration tank from an upper opening thereof, the following effects are obtained. That is, during a normal filtering operation, the lower openings of the hollow body are closed, preventing the entrance of water and filtration sand therein, thereby precluding the accumulation of untreated water therein, as well as the deterioration of water quality by filtration sand that is not used for filtering. Further, the filtration media is entrained in vortices caused by the opposing forces of the downward pull of gravity and the upward motion imparted thereon by the screw conveyor. These vortices cause the contaminated grains of the filtration media to frictionally engage, that is, scrub each other, thereby separating contaminants therefrom, so it is possible to effectively separate the contaminants from the filtration media without the crushing thereof. If a switching mechanism is further provided and in the case that xe2x80x9cfilteringxe2x80x9d is selected by said mechanism, as the cleansing mechanism is not operated, a conventional filtering operation is secured. In the case that xe2x80x9ccleansingxe2x80x9d is selected, the cleansing mechanism is operated, and cleansing is performed utilizing only the water that is resident in the filtration tank, so the amount of water required is kept to a minimum. In addition, if as a final step, a backwash operation is performed to expel the contaminants which have been separated from the filtration media and remain in the filtration tank outside of the container, the filtration media can be cleansed more efficiently and with a higher degree of cleansing than by a conventional backwash operation. As a result, the need to replace the filtration media with new filtration media is obviated; thereby suppressing the costs associated with the introduction of new filtration media. Also, the need to dispose of the used filtration media is obviated, and it becomes possible to maintain environmental protection standards (such as ISO14000) by the control of industrial waste, as well as reduce the costs associated with industrial waste disposal. Further, as the intervals between the cleansing of the filtration media can be extended longer than with conventional systems, longer continuous filtration times can be secured, while decreasing the total time during which filtration is ceased for cleansing operations. Still further, even if multiple cleansing operations are performed, contaminants do not accumulate within the filtration tank. Therefore, replacement of the filtration media and the cleaning of the filtration tank become unnecessary, thereby lowering the costs and labor associated with maintenance thereof. Furthermore, as the filtration apparatus of the present invention is structured so that the cleansing tank houses therein filtration media at all times; said tank has a plurality of vertically extending lateral surface openings; said lateral surface openings have a plurality of lateral surface doors opened and closed by a plurality of drive means; the liquid poured into the filtration apparatus enters the cleansing tanks through said lateral surface openings, which are open in a normal operating state; and filtration occurs in the cleansing tank as well; then during a filtration operation, the filtration area is expanded, thereby improving the filtration efficiency. Also, as liquid flows into the cleansing tank at all times, stagnation of liquid therein is precluded. Therefore, contamination of liquid due to stagnation and the seeping out of said contaminated liquid from the cleansing tank into the filtered liquid and mixing therewith is prevented. Further, during a cleansing operation of the filtration sand, the lateral surface openings are closed, thereby allowing efficient circulation of the filtration sand between the cleansing tank and the container. Further, in the case that the contaminant expulsion means is provided with a backwash mechanism that discharges filtered or clean water into the filtration tank through the filtration floor to cause the filtration media to float at the time when the lateral surface doors are closed in order for the screw conveyor to agitate the filtration sand, the opening and closing of the lateral surface doors is not prevented by the filtration media. That is, the lateral surface doors do not encounter much resistance by the filtration media, which eases the opening and closing operation, and the load on the drive means for opening and closing the lateral surface doors can be reduced. Further, in the case that the lateral surface doors are closed during the time that the screw conveyor is rotating, agitating of the filtration media is efficiently performed. In the case that the contaminant expulsion means is further provided with an overflow expulsion means that expels the contaminants caused to float within the surface layer of the liquid by the discharge of liquid from the backwash mechanism into the filtration tank through the filtration floor at the time when the lateral surface doors are opened at the completion of the agitating operation, not only is the opening of the lateral surface doors eased, but the contaminants can be efficiently discharged from the lateral surface doors as well. In the case that the filtration media cleansing mechanism is further provided with a retention means for retaining the water poured into the container within the filtration tank, the effects of said means combine with those of the opening of the lateral surface doors to more efficiently cleanse the filtration media. If the filtration apparatus is structured so that filtration media is housed in the cleansing tank at all times, the liquid under pressure by the filling of the filtration tank can also be filtered by the cleansing tank. In this case, because the liquid is under pressure, said liquid permeates the filtration media quickly, and because the filtration area is expanded, filtration is performed more efficiently. The present invention, as has been described, is characterized by a cleansing mechanism being built in to a filtration tank so that both filtration and cleansing can be appropriately performed without sacrificing the performance of either.

[Treatment and mechanism of compound carraghenates suppository to rat acute rectal mucous injury]. To investigate the treatment and mechanism of compound carraghenates suppository to rat acute rectal mucous injury. The model of rat acute rectal mucous injury was established by 3% acetic acid. Two hundred and forty rats were divided equally into control and experimental group. The rats of experimental group were administrated with 20 mg carraghenates suppository via rectum twice a day, but rats of control group were not administrated with carraghenates suppository. Thirty rats in both groups were executed at different time points. The pathologic changes were observed and the rectal mucous injury was scored. Immunohistochemical staining was used to evaluate the effect of carraghenates suppository on expression of VEGF, iNOS, IL-8, MMP9, HIF-1 alpha and PCNA in the two groups. The scores of rectal mucous injury was lower, the pathologic changes such as hyperaemia, edema, destroy of glands were less severe, and tissue repair time was shorter in experimental group compared with those in the control group at 24 h, 78 h and 120 h after administration of carraghenates suppository. No obvious cicatrisation was observed in experimental group. Expression of VEGF and MMP9 was significantly lower in experimental group compared with those in the control group at 24 h after administration. Expression of VEGF, iNOS, IL-8, MMP9, HIF-1alpha and PCNA were statistically decreased in experimental group than those in the control group at 72 h, 120 h after administration. MVD in experimental group was statistically decreased than that in the control group. The compound carraghenates suppository can reduce the rectal mucous injury from 3% acetic acid, and accelerate the wound healing without obvious cicatrisation. The compound carraghenates suppository can reduce the expression of MMP9, VEGF, IL-8, PCNA, iNOS and HIF-1 alpha, which may play a role in its protective mechanism.

The present invention relates generally to plasma-based thin film processing. More particularly, the invention relates to an arc control apparatus for DC sputtering systems that decreases the recovery time from an arc. With the increasing demand for optical and disk media such as CD, DVD, MD, MO, DLC films, and hard disks; the importance of the sputtering processes that are used in the manufacture of these media continues to increase. There are numerous types of sputtering systems, all of which are employed to deposit insulating or conductive coatings on devices ranging from semiconductors to drill bits. The films that are generally applied to optical and disk media are typically created with a sputtering process having poor control over the sputtering gas, i.e. a significant fraction of atmosphere and petrochemical volatilities are in the chamber at the beginning of the process. During the initial sputtering phase, atmosphere is introduced into the plasma chamber to combine with freed target material. The resulting compound, typically oxides and nitrides, may form a film on the surface of the target. This is referred to as target poisoning, and will cause arcing in DC sputtering. Arcing, though inevitable in these processes is a mixed blessing. The arc often removes the poisoning from the target, but it may also generate undesirable particles to damage the substrate or disk. Further sources of arcing include contaminants such as moisture, atmospheric gases, inclusions, and outgassing from the workpiece may also cause arcing. In addition to particulate defects, arcing may lead to a defect commonly known as “mousebites”, which is illustrated in FIG. 1. A mousebite 9 is an irregularity that generally occurs along the edges of a workpiece coating. The occurrence of mousebites is related to the configuration of the power supply and attached energy storage components. In applications such as coating CDs, the effect of mousebites can be attenuated by increasing the portion of the workpiece adjacent to the edges that is masked from coating. However, masking limits the usable area of the workpiece, thereby increasing the need for maintenance, i.e. replacement of the mask due to coating buildup. To control arcs, conventional DC sputtering systems include arc suppression systems that are either attached to or integrated into the power supply. Arc suppression systems may be divided into two groups. The first type, periodic arc control systems, cause a periodically occurring interruption or voltage reversal of the cathode voltage in an attempt to avoid arcing. The second type, arc initiated control systems, bring about an interruption only after the beginning of an arc has been detected. Periodic suppression systems universally employ at least one active switch (in shunt or series to the cathode) to interrupt the flow of current or to apply a reverse voltage to the cathode. The frequency and pulse width of the switch are normally set so that arcing is suppressed, thereby eliminating defects that result from target poisoning and its associated arcs. A disadvantage of periodically interrupting the cathode voltage is that the basic deposition rate may be reduced since the cathode voltage is not continuously applied. Another disadvantage of periodic suppression systems is the additional cost of the active devices and associated control circuits. Generally, periodic suppression systems are only employed when defect free deposition is required, such as in the manufacture of semiconductors. Arc initiated control is employed for the manufacture of devices in which lower cost and reduced deposition times are the primary requirements. Traditionally, an arc initiated control system senses the initiation of an arc, and in response disables the power supply driving the cathode. Generally, these control systems permit a significant quantity of energy to be dissipated in the arc before disabling the power applied to the cathode. The quantity of energy dissipated in the arc is also dependent on the type of power supply to which the arc initiated control system is attached. Since arc control systems do not completely prevent arcing like periodic suppression systems, but instead act in response to the detection of an arc, particulate defects to varying degrees will occur. In addition, with some combinations of power supplies and arc initiated control systems, mousebite defects may also occur. In addition, deposition times may also be adversely affected, since while an arc occurs there is no deposition on the substrate. While the prior art can be used to provide a DC sputtering system, it has not proven capable of providing low cost arc control that does not adversely affect the deposition time or the quality of the coating. Accordingly, it is desirable to provide a low defect arc control system that does not compromise the deposition rate of the process. In addition, eliminating defects from the workpiece is desirable. Also, it is desirable to reduce deposition defects caused by target poisoning. The present arc control system and method provide a system for controlling an arc. The arc control system includes a sputtering chamber that houses an anode and a sputtering target formed from a target material and serving as a cathode. A DC power supply provides a DC cathode voltage such that a cathode current flows from the anode to the cathode. A resonant network is coupled between the DC power supply and the chamber. The resonant network has sufficient Q so that in reaction to the occurrence of an arc, the cathode current resonates to a negative value as is well known in the art. A reverse voltage clamp is coupled across the resonant network to clamp the cathode voltage to a predetermined reverse voltage value, and allow the negative portion of the resonant waveform to drive the cathode and reverse charge the target surface. Thus reverse current of the network is allowed to flow unimpeded to the cathode. This reverse current then charges the cathode to a clamped positive voltage. For a more complete understanding of the invention, its objects and advantages, reference may be had to the following specification and to the accompanying drawings.

1. Field of the Invention The present invention relates generally to a circuit-terminal connecting device, and more particularly to an improvement in a circuit-terminal connecting device which comprises first and second electrical connectors fixed respectively to first and second circuit boards including flexible printed circuit boards (FPCs) to be used for putting first and second groups of circuit-terminals provided respectively on the first and second circuit boards in mutual electrical connection under a condition wherein the first and second electrical connectors are coupled with each other so that the second circuit board is closely laid on top of the first circuit board. 2. Description of the Prior Art Including Information Disclosed Under 37 CFR 1.97 and 37 CFR 1.98 Various kinds of electric or electronic parts are built even in a relatively small-sized electronic apparatus such as a mobile phone or the like. A major part of those parts are dispersedly mounted on, for example, a couple of separate circuit boards to fulfill their respective functions. In the relatively small-sized electronic apparatus, having an eye to the couple of separate circuit boards on which the electric or electronic parts are mounted, it is likely that one of the separate circuit boards is required to be closely laid on top of the other of the separate circuit boards for reducing a space occupied thereby when the separate circuit boards are electrically connected with each other. Such electrical connection between the separate circuit boards wherein one is closely laid on top of the other is hereinafter referred to as electrical piled-up connection. In general, when a plurality of groups of circuit-terminals provided respectively on a plurality of circuit boards are put in mutual electrical connection, a plurality of electrical connectors are respectively fixed to the circuit boards, and one of the electrical connectors is coupled with another of the electrical connectors so as to connect the circuit boards, on which the electrical connectors are respectively fixed, electrically with each other. In case of such an electrical piled-up connection as mentioned above, first and second electrical connectors are respectively fixed on the separate circuit boards to be coupled with each other. For example, the first electrical connector is formed into a receptacle type connector and the second electrical connector is formed into a plug type connector to be a mate electrical connector, so that the plug type connector is engaged with the receptacle type connector when the separate circuit boards are put in a condition of the electrical piled-up connection. The first and second connectors provided to be coupled with each other as described above are required to be maintained stably in a mutual coupling condition. Under such a situation, there have been previously proposed several circuit-terminal connecting devices, each of which comprises first and second electrical connectors fixed respectively to first and second circuit boards and locking means for locking mechanically the first or second electrical connector to the second or first electrical connector when the first and second electrical connectors are coupled with each other for putting first circuit-terminals provided on the first circuit board and second circuit-terminals provided on the second circuit board in mutual electrical connection, as disclosed in, for example, the Japanese patent application published before examination under publication number 2005-267977 (hereinafter, referred to as published prior art document 1) and the Japanese patent application published before examination under publication number 2009-170250 (hereinafter, referred to as published prior art document 2). A circuit-terminal connecting device disclosed in the published prior art document 1 comprises a first electrical connector (a plug connector 100) having a first housing (an insulator 11) and a manipulatable member (a pull-bar 10) mounted on the first housing to be rotatable and a second electrical connector (a receptacle connector 102) having a second housing (an insulator 21). The manipulatable member mounted on the first housing is made of metallic bar material to have an arm portion (10b) at each of both ends thereof and a rotating axis (10a) to form a top end of the arm portion. The rotating axis extends to pass through an outside wall portion of the first housing from the outside to the inside of the same so as to constitute a locking portion (a part of a locking mechanism) to the second electrical connector. A rib (7) is provided on an external surface of the outside wall portion of the first housing to project outwardly and a protrusion (1) is provided on an external surface of an inside wall portion of the second housing. When the first and second electrical connectors are coupled with each other, the outside wall portion of the first housing of the first electrical connector is placed at the outside of the inside wall portion of the second housing of the second electrical connector so that the first housing is engaged with the second housing. On that occasion, the rotating axis of the manipulatable member provided on the first housing of the first electrical connector engages with the protrusion provided on the external surface of the inside wall portion of the second housing of the second electrical connector to put the first housing in mechanical lock to the second housing so that first and second electrical connectors are maintained in the mutual coupling condition. After that, when the manipulatable member provided on the first housing of the first electrical connector is rotated, the arm portion of the manipulatable member is moved to get on the rib provided on the external surface of the outside wall portion of the first housing so that the manipulatable member is resiliently deformed to shift the rotating axis of the manipulatable member to the outside of the inside wall portion of the second housing of the second electrical connector and thereby the rotating axis of the manipulatable member disengages from the protrusion provided on the external surface of the inside wall portion of the second housing. Consequently, the first housing is released from the mechanical lock to the second housing by the locking portion including the rotating axis of the manipulatable member. After the rotating axis of the manipulatable member has disengaged from the protrusion provided on the external surface of the inside wall portion of the second housing, the manipulatable member is further rotated to be resiliently restored to the original state. Then, a circuit-terminal connecting device disclosed in the published prior art document 2 comprises a first electrical connector (a receptacle connector 200) having a first housing (an insulator 202) and a metallic member (a shell 250) covering a major part of the first housing and a second electrical connector (a plug connector 300) having a second housing (an insulator 340) and a manipulatable member (a pull-bar 370) mounted on the second housing to be rotatable. The metallic member of the first electrical connector has a locking portion (252) on which an engaging hole (254) is formed. The manipulatable member mounted on the second housing is made of metallic bar material to have a main portion (372), a connecting portion (376) extending to be bent in a direction crossing the main portion from each of end portions of the main portion opposite to each other, and an engaging portion (374) extending to be bent further in a direction along the main portion from each of the connecting portions. The second housing of the second electrical connector has an outside wall portion, on an internal surface of which a cam portion (348) is provided. The engaging portion of the manipulatable member extends to pass through the outside wall portion of the second housing from the inside to the outside of the same so that a top end of the engaging portion projects to the outside of the outside wall portion of the second housing to constitute a locking end portion (375) to the first housing of the first electrical connector. When the first and second electrical connectors are coupled with each other, the outside wall portion of the second housing of the second electrical connector is placed at the inside of the locking portion of the metallic member of the first electrical connector, on which the engaging hole is formed, so that the second housing is engaged with the first housing. On that occasion, the locking end portion at the top end of the engaging portion of the manipulatable member provided on the second housing of the second electrical connector engages with the engaging hole formed on the locking portion of the metallic member of the first electrical connector to put the second housing in mechanical lock to the first housing so that first and second electrical connectors are maintained in the mutual coupling condition. After that, when the manipulatable member provided on the second housing of the second electrical connector is rotated, the connecting portion of the manipulatable member is moved under guidance with the cam provided on the internal surface of the outside wall portion of the second housing so that the manipulatable member is resiliently deformed to shift the locking portion at the top end of the engaging portion extending to be bent from the connecting portion of the manipulatable member to the inside of the outside wall portion of the second housing and thereby the locking end portion at the top end of the engaging portion of the manipulatable member disengages from the engaging hole formed on the locking portion of the metallic member of the first electrical connector. Consequently, the second housing is released from the mechanical lock to the first housing by the locking end portion at the top end of the engaging portion of the manipulatable member. After the locking end portion of the manipulatable member has disengaged from the engaging hole formed on the locking portion of the metallic member of the first electrical connector, the manipulatable member is further rotated to be resiliently restored to the original state. In the previously proposed circuit-terminal connecting devices, each of which comprises first and second electrical connectors fixed respectively to first and second circuit boards and locking means for locking mechanically the first or second electrical connector to the second or first electrical connector when the first and second electrical connectors are coupled with each other for putting first circuit-terminals provided on the first circuit board and second circuit-terminals provided on the second circuit board in mutual electrical connection, as described above, there are the following defects or disadvantages. In the case of the circuit-terminal connecting device disclosed in the published prior art document 1, the rotating axis of the manipulatable member made of metallic bar material to be provided on the first housing of the first electrical connector engages with the protrusion provided on the second housing of the second electrical connector to put the first housing in mechanical lock to the second housing under a condition wherein the manipulatable member is not resiliently deformed when the first and second electrical connectors are coupled with each other and then the rotating axis of the manipulatable member disengages from the protrusion provided on the second housing to release the first housing from the mechanical lock to the second housing under a condition wherein the manipulatable member is resiliently deformed. Accordingly, under a condition wherein a locked state in which the first housing is put in the mechanical lock to the second housing and an unlocked state in which the first housing is released from the mechanical lock to the second housing are taken repeatedly, the rotating axis of the manipulatable member engages with the protrusion provided on the second housing to put the first housing in the mechanical lock to the second housing under a condition wherein the manipulatable member is caused to restore not to be resiliently deformed after being once deformed resiliently. Therefore, it is feared that the arm portion of the manipulatable member is undesirably subjected to plastic deformation so as not to restore appropriately to the original state when the manipulatable member is caused to restore not to be resiliently deformed after being once deformed resiliently. In the case where such a plastic deformation as mentioned above is brought on the arm portion of the manipulatable member, the rotating axis of the manipulatable member is shifted in its position by the plastic deformation of the arm portion of the manipulatable member so as not to engage appropriately with the protrusion provided on the second housing and thereby the first housing is put in unsure or unstable mechanical lock to the second housing. Further, in the circuit-terminal connecting device disclosed in the published prior art document 1, the rotating axis of the manipulatable member is supported by the outside wall portion of the first housing after having passed through the same from the outside to the inside thereof to engage with the protrusion provided on the second housing. That is, the rotating axis of the manipulatable member is not supported by any metallic member having relatively large stiffness but supported by the first housing made of insulating material inferior in stiffness for locking the first housing to the second housing. Therefore, especially under a situation wherein a thickness of each of the first and second housings is reduces for miniaturization and reduction in weight of the first and second electrical connectors, it is feared that the rotating axis of the manipulatable member is unsurely or unstably supported by the outside wall portion of the first housing so as not to engage surely and reliably with the protrusion provided on the second housing. Then, in the case of the circuit-terminal connecting device disclosed in the published prior art document 2, the locking end portion at the top end of the engaging portion of the manipulatable member made of metallic bar material to be provided on the second housing of the second electrical connector engages with the engaging hole formed on the locking portion of the metallic member of the first electrical connector to put the second housing in mechanical lock to the first housing under a condition wherein the manipulatable member is not resiliently deformed when the first and second electrical connectors are coupled with each other and then the locking end portion of the manipulatable member disengages from the engaging hole formed on the locking portion of the metallic member of the first electrical connector to release the second housing from the mechanical lock to the first housing under a condition wherein the manipulatable member is resiliently deformed. Accordingly, under a condition wherein a locked state in which the second housing is put in the mechanical lock to the first housing and an unlocked state in which the second housing is released from the mechanical lock to the first housing are taken repeatedly, the locking end portion of the manipulatable member engages with the engaging hole formed on the locking portion of the metallic member of the first electrical connector to put the second housing in the mechanical lock to the first housing under a condition wherein the manipulatable member is caused to restore not to be resiliently deformed after being once deformed resiliently. Therefore, it is feared that the engaging portion of the manipulatable member is undesirably subjected to plastic deformation so as not to restore appropriately to the original state when the manipulatable member is caused to restore not to be resiliently deformed after being once deformed resiliently. In the case where such a plastic deformation as mentioned above is brought on the engaging portion of the manipulatable member, the locking end portion of the manipulatable member is shifted in its position by the plastic deformation of the engaging portion of the manipulatable member so as not to engage appropriately with the engaging hole formed on the locking portion of the metallic member of the first electrical connector and thereby the second housing is put in unsure or unstable mechanical lock to the first housing. Further, in the circuit-terminal connecting device disclosed in the published prior art document 2, the engaging portion of the manipulatable member is supported by the outside wall portion of the second housing, on the internal surface of which the cam portion is provided, after having passed through the same from the inside to the outside thereof so as to cause the locking end portion at the top end of the engaging portion to engage with the engaging hole formed on the locking portion of the metallic member of the first electrical connector. That is, the engaging portion of the manipulatable member having the locking end portion at its top end is not supported by any metallic member having relatively large stiffness but supported by the second housing made of insulating material inferior in stiffness for locking the second housing to the first housing. Therefore, especially under a situation wherein a thickness of each of the first and second housings is reduces for miniaturization and reduction in weight of the first and second electrical connectors, it is feared that the engaging portion of the manipulatable member is unsurely or unstably supported by the outside wall portion of the second housing so that the locking end portion at the top end of the engaging portion is not able to engage surely and reliably with the engaging hole formed on the locking portion of the metallic member of the first electrical connector.

Risk messages about HPV, cervical cancer, and the HPV vaccine Gardasil: a content analysis of Canadian and U.S. national newspaper articles. The human papillomavirus vaccine (Gardasil) is a significant advancement in women's health. We compared the reporting of fear-inducing messages about human papillomavirus, cervical cancer, and the human papillomavirus vaccine in Canadian and U.S. national newspapers between January 2006 and December 2007. Significant differences between countries were found in the number of articles containing fear messages about human papillomavirus, cervical cancer, and the human papillomavirus vaccine. Educational level of readability was higher than recommended for the public, and the emotional tone of the articles became progressively negative over time. Our findings suggest that public discussion of some elements of the human papillomavirus vaccine message that could cause alarm or worry for women may need to be addressed within political and cultural contexts.

Transposase activity was thought to be extinct in humans because DNA movement can be deleterious in higher organisms, resulting in genomic instability and perhaps malignancy. However, we isolated a human transposase protein termed Metnase that had histone methylase and non-homologous end-joining (NHEJ) DNA repair activity. It was found to interact with DNA Ligase IV, consistent with its NHEJ repair activity. Metnase also was an endonuclease preferential for supercoiled DNA. We therefore explored Metnase's role in decatenating replicated chromatids. Metnase interacted with Topoisomerase II (Topo II ), the critical decatenating enzyme, and enhanced its activity in DNA decatenation, both in vitro and intracellularly. The nuclease activity within the transposase domain of Metnase was required for full enhancement of Topo II decatenating activity. Metnase improved the rate at which Topo II decatenated DNA, and increased the ability of Topo II to resist the decatenation inhibitor ICRF-193. The finding that Metnase improved Topo II resistance to ICRF-193 stimulated an investigation into whether it could mediate resistance to the clinically relevant Topo II inhibitor etoposide. We found that Metnase prevented inhibition of Topo II decatenation by etoposide in vitro, and mediated cellular resistance to etoposide, promoting proliferation in the presence of etoposide. Metnase also promoted a more rapid clearance of etoposide-induced DSB. Thus, Metnase appeared to mediate resistance to etoposide-induced DNA damage and cell cycle arrest. This is a novel mechanism of etoposide resistance that is unexplored. This application proposes to define the mechanism by which Metnase mediates resistance to etoposide by asking three questions: 1) What are the upstream signals that regulate the ability of Metnase to reduce etoposide DSBs? 2) What is the downstream pathway by which Metnase reduces etoposide DSBs? 3) Do Metnase levels predic clinical resistance to etoposide in human malignancy? PUBLIC HEALTH RELEVANCE: We have isolated a novel protein termed Metnase that helps chromosomes repair breaks and also untangle, thereby allowing them to separate properly during cell division. Because of these actions, Metnase mediates resistance to the cancer drug etoposide. Understanding the mechanism by which Metnase does this would allow the generation of drugs targeting Metnase, which could help improve the response of cancer patients to etoposide. In addition, the levels of Metnase could predict which patient will respond to etoposide.

Attrition in an exercise intervention: a comparison of early and later dropouts. To identify reasons for dropout and factors that may predict dropout from an exercise intervention aimed at improving physical function in frail older persons. An 18-month randomized controlled intervention in a community setting. The intervention comprised 2 groups: class-based and self-paced exercise. 155 community-dwelling older persons, mean age 77.4, with mildly to moderately compromised mobility. The primary outcome measure was dropout. Dropouts were grouped as: D0, dropout between baseline and 3-month assessment, and D3, dropout after 3-month assessment. Measurements of demographics, health, and physical performance included self-rated health, SF-36, disease burden, adverse events, PPT-8, MacArthur battery, 6-minute walk, and gait velocity. There were 56 dropouts (36%), 31 in first 3 months. Compared with retained subjects (R), the D0 group had greater disease burden (P = .011), worse self-perceived physical health (P = .014), slower usual gait speed (P = .001), and walked a shorter distance over 6 minutes (P<.001). No differences were found between R and D3. Multinomial logistic regression showed 6-minute walk (P<.001) and usual gait velocity (P<.001) were the strongest independent predictors of dropout. Controlling for all other variables, adverse events after randomization and 6-minute walk distance were the strongest independent predictors of dropout, and self-paced exercise assignment increased the risk of dropout. We observed baseline differences between early dropouts and retained subjects in disease burden, physical function, and endurance, suggesting that these factors at baseline may predict dropout. Improved understanding of factors that lead to and predict dropout could allow researchers to identify subjects at risk of dropout before randomization. Assigning targeted retention techniques in accordance with these factors could result in decreased attrition in future studies. Therefore, the results of selective attrition of frailer subjects, such as decreased heterogeneity, restricted generalizability of study findings, and limited understanding of exercise effects in this population, would be avoided.

Non-return valves or check valves have long been known for allowing fluid flow in only one direction. Any reversal of the flow in the undesired direction results in stoppage or checking of the flow. This invention relates to a specific body construction and assembly for a check valve for carrying a fluid flow. Typical prior art check valve assemblies are comprised of a flow section, a plurality of flappers, a stop tube for controlling the angle of opening of the flappers, and a plurality of vertical supports, commonly referred to as ears, for supporting the stop tube in its proper position. The stop tube is commonly held in place relative to the vertical supports through the use of an external fixation or retention device, such as a pin, or weld deposit about an end of the stop tube where it is inserted into and meets the vertical support. In many applications, it is desirable to provide a check valve at one or more spaced locations in a pipe line or conduit for handling fluid flows. The check valve assures against back flow and provides a safety margin in the unlikely event of line breakage. These types of check valves, commonly referred to as insert check valves, preferably do not use an external mechanism be used for stop tube retention, thereby allowing for insertion of the check valve within confined space, such as a pipe, or the like. In addition, in many applications, when a check valve is assembled using external methods to retain the stop tube assembly, heat becomes a factor and may result in the shrinking of the stop tube supports, causing critical deformation. Hence, there is a need for a check valve including a check valve stop assembly that when retained within a plurality of vertical supports of the check valve flow body provides retention without the use of an external fixation or retention device. In addition, there is a need for a check valve stop assembly that is not susceptible to extreme heat conditions.

Improving quality of care during labour and childbirth and in the immediate postnatal period. Quality of care during labour and childbirth and in the immediate postnatal period is important in ensuring healthy maternal and newborn survival. A narrative review of existing quality frameworks in the context of evidence-based interventions for essential care demonstrates the complexities of quality of care and the domains required to provide high quality of care. The role of the care provider is pivotal to optimum care; however, providers need appropriate training and supervision, which should include assessment of core competencies. Organisational factors such as staffing levels and resources may support or hinder the delivery of optimum care and should be observed during any monitoring. The woman's perspective is central to all quality of care strategies; her opinion should be sought where possible. The importance of assessing and monitoring quality of care during such a critical period should be appreciated. A number of quality frameworks offer organisations with a foundation on which they can deliver high quality care.

1. Field of the Invention The invention relates to an apparatus for recording an electric signal on a magnetic record carrier in tracks which are inclined relative to the longitudinal direction of said record carrier, and to an apparatus for reproducing a signal recorded by means of such a recording apparatus. 2. Description of the Related Art Corresponding to U.S. Pat. No. 4,757,392, discloses European Patent Application 210,773 a recording apparatus as defined in the opening paragraph, comprising: - an input terminal for receiving the electric signal; PA1 - a signal separator, having an input coupled to the input terminal for dividing the electric signal into consecutive blocks having a specific length of time, and for applying the consecutive blocks to a first and a second output in such a way that blocks having odd sequence numbers are applied to the first output and blocks having even sequence numbers are applied to the second output; PA1 - a time-base correction circuit which is constructed to provide time compression or time expansion of the consecutive blocks, to delay blocks having odd sequence numbers relative to those having even sequence numbers, and to supply the two signals thus processed to a first and a second output, respectively; PA1 - at least one pair of write heads having different azimuth angles and arranged on a rotatable head drum, one write head of a pair being arranged to be coupled to the first output of the time-base correction circuit and the other write head of the same pair being arranged to be coupled to the second output of the time-base correction circuit. PA1 - at least one pair of read heads having different azimuth angles, and arranged on a rotatable head drum; PA1 - a time-base correction circuit having a first and a second input arranged to be coupled, respectively, to one read head and to the other read head of the pair of read heads, the correction circuit being constructed to provide a time compression or time expansion of the signal blocks applied to the first and the second input respectively, to delay the signal blocks applied to one input relative to those applied to the other input, PA1 - a signal-combination unit having a first and a second input and an output, for combining the signal blocks applied to the first and the second input in order to restore the electric signal and for feeding the electric signal to the output, which output is coupled to an output terminal for supplying the electric signal. The two write heads of a pair of write heads are regularly spaced along the drum circumference. The known apparatus can also be used as a reproducing apparatus, in which case it comprises: The known apparatus has the disadvantage that during operation it produces a high acoustic noise level, that only very dimensional tolerances of the components are permissible, and that sometimes the reproduction quality is not satisfactory. The invention aims at mitigating these drawbacks and therefore proposes an apparatus for recording an electric signal which is characterized in that the write heads of a pair of write heads are are arranged close to each other and have a mechanically rigid coupling to each other, and in that the time base correction circuit is adapted to provide a time expansion or time compression of the signal blocks by a factor of .alpha.*n/(180*(M+1), where .alpha. is the wrapping angle of the record carrier around the head drum and differs from 180.degree., n is the number of head pairs, and M is the number of times within a specific time interval that a head pair which comes in contact with the record carrier during said time interval does not record a signal in the record carrier, this time interval being defined by those instants at which two consecutive track pairs are recorded by one or two head pairs. The apparatus for reproducing an electric signal is characterized in that the read heads of one pair of read heads are arranged close to each other and have a mechanically rigid coupling to each other, and in that the time-base correction circuit is adapted to provide a time compression or time expansion of the signal blocks applied to the first and the second input by a factor of 180*(M+1)/(.alpha.*n), where .alpha. is the wrapping angle of the record carrier around the head drum and differs from 180.degree., n is the number of head pairs and M is the number of times within a specific time interval that a head pair which comes in contact with the record carrier during said time interval does not read a signal from the record carrier, the two track pairs being read consecutively by one or two head pairs. As the heads of one pair of read or write heads are arranged at one location on the head drum, these heads hit against the record carrier only once every revolution of the head drum during recording and reproduction which enables the acoustic noise level to be reduced. In the case of head-level variations which manifest themselves similarly during every revolution of the head drum, for example as a result of wobbling or hunting of the head drum, the tracks written by the two heads of one pair of heads are yet recorded parallel to each other on the record carrier. The tracks may then be warped. However, if the apparatus comprises positioning means for positioning the head pair in a direction transverse to the track, said tracks can still be read correctly. Moreover, if the positioning means are constructed as a dynamic tracking system, only one actuator is needed, on which the pair of heads is arranged. In the known apparatus, in which the heads of a pair of write or read heads are spaced at 180.degree. from each other along the head drum circumference and which comprises a dynamic tracking system, "false lock" may occur. This means that tracks are sometimes recorded or read in a wrong sequence. This is because the heads are not disposed at the same level relative to each other. Said false lock problem does not occur in the apparatus in,accordance with the invention because the heads of a pair of write or read heads are now arranged close to each other and have a rigid mechanical coupling to each other, said heads being arranged, for example, on one actuator. Consequently a control system for maintaining the heads at the same level, as is required in the known apparatus, is not needed now. In a first embodiment n=1 and M=0. This means that one head pair is arranged on the head drum and records or reads one track pair during every revolution of the head drum. If the wrapping angle is smaller than 180.degree. the correction circuit in the recording apparatus should provide a time compression of the signal by a factor of .alpha./180 and, consequently, the correction circuit in the reproducing apparatus should provide a time expansion of the signal by a factor of 180/.alpha.. If the wrapping angle is larger than 180.degree. the correction circuit in the recording apparatus should provide a time expansion of the signal and the correction circuit in the reproducing apparatus should provide a time compression of the signal. In another embodiment n=1 and M=1. This means that only one head pair is arranged on the head drum. This head pair writes or reads one track pair during every two revolutions of the head drum. During recording the signal should then be time-compressed by a factor of .alpha./360 and during reproduction the signal must be time-expanded by a factor of 360/.alpha.. The apparatus may be characterized further in that it comprises a second pair of write or read heads having different azimuth angles and arranged on the rotatable head drum, said second pair of heads being arranged close to each other and having a mechanically rigid coupling to each other. An apparatus comprising two or more head pairs which are equidistantly spaced along the circumference enables information to be recorded or read at different tape speeds but with a constant speed of rotation of the head drum. An apparatus comprising two head pairs which are 180.degree. spaced apart on the head drum can record at the "normal" tape speed and at a tape speed which is twice as high. In the first case, only one pair of heads records adjoining tracks on the record carrier. For the parameters n and M this means that n=2 and M=1. At a tape speed which is twice as high, a spacing will be obtained between two tracks recorded directly after each other by one pair of heads, in which spacing the other pair of heads can record exactly one track. At this speed both pairs of heads consequently record tracks on the record carrier. For the parameters n and M, this means that n=2 and M=0. Obviously, the same applies during reproduction. If during recording the tracks have been recorded at the normal tape speed only one pair of read heads is used for reading the information during reproduction. If during recording the tracks have been recorded at twice the normal tape speed, both pairs of read heads are used during reproduction, the tape speed being equal to that during recording. The information recorded by the second pair of write heads may comprise additional information, for example the finest detail of an encoded video picture or an entirely different signal, or it enables a higher resolution standard to be adopted. Recording or reading information at different tape speeds and constant speed of rotation of the head drum is also possible in the case of more than two pairs of write or read heads. For example, in the case of three pairs of heads writing and reading at the normal tape speed is effected with one write head or read head (n=3 and M=2), while at three times the speed, all the three heads are operative (n=3 and M=0). It is to be noted that recording and reproducing a digital video signal by means of at least one pair of heads which are arranged close to each other and which have a mechanically rigid coupling with each other is known and is described in the publication "An experimental digital video recording system" by Driessen et al in IEEE Trans. on CE, Vol. CE-32, No. 3, August 1986, pp. 362-70. However, in this system, the video signal is not time compressed or expanded. Neither is one signal component delayed in time relative to the other.

Hearing instruments for the elderly hearing impaired. A comparison of in-the-canal and behind-the-ear hearing instruments in first-time users. The purpose of this investigation was to compare negative and positive experiences between two matched groups of elderly first-time users of hearing instruments (HI). One group had been supplied with behind-the-ear hearing instruments (BTE), the other with in-the-canal hearing instruments (ITC). There were 20 persons in each group. All were visited in their homes. Those who needed extra help were offered follow-up at the Hearing Centre. ITC were found to be superior to BTE as regards time-of-use, operational difficulties and undesirable sound experiences. ITC were also used in more difficult listening situations. Successful instruction and follow-up was more easily achieved with ITC users than with BTE users. ITC are recommended as the preferred instrument for elderly first-time HI users, at least for hearing losses not exceeding 60 dB PTA, provided the subject's dexterity and anatomical conditions permit fitting of ITC.

The present invention relates to a device for manufacturing so-called gobs from glass. Such gobs serve as intermediate products for optical articles, such as lenses. U.S. Pat. No. 5,762,673 describes a device, in which glass balls defined by dropping are produced from a molten mass of glass. The glass balls are kept in suspension in a gas stream while at the same time being brought to a specific temperature and a specific viscosity. In a further procedural step the glass gobs are subjected to a pressing procedure, followed by further processing steps. The present invention focuses on that phase of the known process, in which the glass gob is kept in suspension for a certain period by means of a gas stream. During this time the glass balls or gobs can cool off, be heated and/or kept at a certain temperature. The associated device comprises a membrane of an open-pored material as an essential element. The membrane may be discoid. The disc can be even or have the shape of a trough corresponding to the shape of the glass gob. JP-A-H10-139465 describes such membranes. These have the form of a trough-like circular disc which is clamped by its outer circumference in the carrier. The circular disc is relatively thin-walled and comprises an upper and lower surface. A compressed gas is applied to the lower surface, which migrates through the pores of the membrane and exits again at the upper surface of the membrane. Glass drops from a molten mass are applied intermittently to the membrane. The individual glass drop is suspended for a certain time by the compressed gas exiting from the upper membrane surface, as per procedural requirements. The known devices are encumbered with disadvantages. A particular disadvantage is that the membrane material exhibits minimal stability only. From this viewpoint considerable wall strength of the membrane is preferable to reduce the risk of breakage. On the other hand, with a given gas pressure, a specific quantity of gas should penetrate through the membrane from top to bottom to guarantee that the gas cushion required to levitate the glass gob develops. To prevent unnecessarily high supply gas pressures, the membrane must be made thin-walled.

"Kids, back in 2009, your Aunt Robin was the host of a morning show for local New York cable." "And it was on pretty early." "How early?" "Mike?" "wake up!" "But then, everything changed." "Hey." "Hey." "See my show?" "Oh, I meant to watch it." "I just got so busy with the whole "being sound asleep" thing." "It took all night, eight hours down the drain." "Oh, it's fine." "But get this:" "After the broadcast..." "Hi." "Are you Robin?" "Yeah." "I'm Don, your new co-host." "Don was Don Frank, seasoned veteran of no fewer than 39 local morning news teams from all over the country." "The guy was an industry legend." "Oh." "Wow!" "You are so going to hit that." "No, I just think we're going to be great together on the air." "And on the sofa and on the bed and on the coffee table." "All right, all right." "I'm gonna go up on the roof and stand there by myself for five minutes." "Have fun." "And that's exactly what she did." "She just stood there." "All right, kids, I'm gonna level with you." "That's not what she did." "Here's what she did." "All right, all right." "I'm going to go have a cigarette." "What?" "!" "I promised her I'd never tell you this, but once upon a time, your Aunt Robin did enjoy the occasional cigarette, and occasionally that occasional cigarette... was more than just occasional." "I just left something like this in my apartment." "Robin, come on, take it to the roof." "We said no smoking in the apartment after you torched the throw rug doing push-ups." "All right, all right, all right." "Geez." "Yeah, Robin, I mean, God, not only is that a filthy habit, but also, can I bum one?" "Sure." "What?" "!" ""How I Met Your Mother"" " Sync By YesCool " "Kids, your Uncle Marshall definitely doesn't want you to know this, but he also smoked off and on." "It all started when he was 13, on a camping trip in Minnesota." "Come on, Marshall, let's celebrate." "It's summer vacation." "Okay, but just one." "This is my first and last cigarette ever." "And that was the first of many, many "last cigarettes ever."" "That's it." "I am done, I am out." "Last..." "Cigarette ev-arrh!" "So, by that point, I'd heard it all before." "Last cigarette ever." "What are you doing?" "You haven't smoked in six months." "Is this about the McRib?" "It's gone, dude, let it go." "I'm worried about work, okay?" "They just hired a new head of the legal department, and he's going to be letting people go." "So that's why you're worried?" "The new head of the legal department is Arthur Hobbes." "As in "Artillery Arthur"?" "As in your former boss?" "Arthur Hobbes was the meanest boss" "Marshall or anyone else had ever had." "The last time Marshall worked for him, it ended like this." "I quit!" "Yikes." "So does he hold it against you?" "Worse." "I'm sorry, who are you?" "I'm, I'm Marshall Eriksen." "Hmm." "Um, we had a fairly intense screaming match." "No." "Wherein I suggested that you take your head and store it within yourself in a fashion that, while, while space-saving, might limit its exposure to, to sunshine." "Well, that describes 95% of my employees and everyone in my family..." "except for my dog." "He's such a good boy." "Well..." "I'll see you later, uh..." "Randall Wilkerson." "Marshall Eriksen." "Gary Dinkersfield, right." "Great, he doesn't remember you." "Not great." "Arthur Hobbes hating Marshall-- that's no big deal." "He hates everyone." "It's the people he doesn't know that he cuts loose." "He just fired What's-His-Face." "He fired What's- His-Face, Ted, and What's-His-Face was invaluable." "Look, I can understand you getting upset, but it's not worth killing yourself over." "Yeah, wait till you get laid off, then kill yourself." "Like What's-His-Face." "Although I guess now it's more like Where's-His-Face." "Look, it was just two cigarettes." "Okay, I can handle two." "As long as I don't have three within 24 hours, then I'm not going to get hooked again." "What's Lily going to say when she finds out you smoked?" "Lily's not going to find out." "I have a system." "Ah, yes, Marshall's system." "Hey, Lil." "You smoked." "Damn it!" "The next morning, your Aunt Robin was thrilled to be finally going on the air with a real pro." "In three, two, one..." "Hi, I'm Robin Scherbatsky." "And I... am Don Frank." "Two teens were arrested late last night for stealing a police cart." "No, I'm sorry, not a police cart, a police car." "Oh." "Aw, screw it." "Brain fart." "Don't you hate those?" "Oh, look at that, the teleprompter's still running." "Something about a woman giving birth on an uptown bus." "Well, no point in jumping in halfway." "I'll just wait till it's done." "Uh... and she cut the cord with a Metropass." "We'll be right back." "And we're clear." "What the hell was that?" "Don, you said "brain fart."" "Look, Robin, you seem like a nice kid, but this is my 39th local news show, okay?" "And in that time, I've learned three things:" "avoid the all-you-can-eat sushi buffet in Bismarck, do not go to the bathroom with your lapel mic still on, and three, at this hour, your entire viewing audience is one half-drunk slob sitting in his underwear, so..." "Back in five, four..." "Well, let's do a great show for that half-drunk slob." "Well, that half-drunk slob appreciates it." "The next day, Marshall found himself craving a cigarette." "It was driving him crazy, so he decided to get some fresh air." "Oh, no." "You're not up here to jump, are you?" "No, no, no, no." "I fired a lot of people today." "I don't need another jumper in my file." "Oh, uh, cigarette?" "No, no, thank you." "Too bad." "You know what I miss, Jeffrey?" "Getting to know somebody over a smoke." "People are so interchangeable now, but you share a butt with somebody, you got a real bond." "You know what?" "I will, I will take one." "Okay." "I'm Marshall, by the way, it's Marshall, Marshall Eriksen." "Yeah." "Tell me something Marshall Eriksen." "How would you like to see a picture of the cutest dog in the world?" "Hey." " You smoked." "Yes, I smoked, and it was my third of the day." "You know what that means?" "I'm a smoker now." "It's all over." "I even bought a pack on the way home and a lighter and a Vikings lamp, which has nothing to do with anything, but I saw it in the window and I liked it." "Damn it, Marshall." "We already have four Viking lamps and smoking kills." "It was a way to bond with my boss, okay?" "You should have seen me up there." "That is a cute dog." "Yeah." "Are those your kids?" "Yeah, yeah, whatever." "Hey, oh, look what I got at the mall." "Aw." "There he is." "There he is." "Go ahead, you can pet him now." "No." "Yeah, yeah, come on, he likes it." "Scratch him under the chin." "I don't care what your reasons are." "You know how I feel about smoking." "Now, give me the cigarettes." "And the lighter." "Ah, that's the stuff." "What?" "!" "What?" "!" "Oh, yeah, add your Aunt Lily to the list." "Whenever Uncle Marshall fell off the wagon, your Aunt Lily got dragged right down with him." "What you doing?" "If you must know, I am reaching out to City Hall to try to get the mayor on our show." "Oh, my goodness, you are adorable, but the mayor's not coming on a show nobody watches." "My colonoscopy had more viewers than this show." "At least that had some twists and turns." "You know, I don't, I don't know why you're acting like this." "Maybe you're just bitter because you never had a shot at a network job, but I think I still do, so I really need to focus." "I've been on a network." "You were on a network?" "It was the best Labor Day weekend of my life." "When you do the news, you're in these ergonomic chairs." "It feels like you're sitting on a cloud." "Which was nice 'cause it was right after my colonoscopy." "And the dressing rooms?" "Oh." "There's dressing rooms?" "Oh, you bet your sweet headset there's dressing rooms, Mike." "No changing in the KFC bathroom across the street." "No, sir." "It was heaven." "But the second you get used to it, they go find someone who isn't "going through a bitter divorce"" "and doesn't "reek of gin,"" "and before you know it, you're stuck in a dead-end gig, surrounded by people going nowhere, doing the news in your tighty whities." "Okay, the underwear thing was your choice, and I don't like that it's catching on." "Ah, looking good, fellas." "Feels good, right?" "God, I want to kill him." "Of course people watch the show." "You guys watch the show, that's, like, two right there." "Oh, my God." "You guys still haven't seen my show." "What?" "We never miss it." "We've seen it!" "Really?" "What color is the set?" "Uh..." "Yeah, uh..." "It's black." "Right." "Yeah." "With, like, silver" "Uh-huh." "Yeah." "around the edges." "Not your TV set, my show set." "Ah..." "Oh..." "God, if I can't even get my best friends to watch, who's going to watch?" "Lots of people." "Uh, you got bedridden insomniacs." "Hmm." "Bums camping outside a department store." "People waiting in the ER, where the TV is in a cage, so you can't change the channel." "Ooh, do you have any stalkers?" "Yeah, but even Leonard won't watch my show." "I can't believe those guys are smoking out there." "It's freezing out." "Remember when you used to be able to smoke in bars?" "Oh, hey, dude." "I think that hot girl over there's smiling at me." "Uh, that's a chair." "But yeah, dude, hit that." "Guys?" "Marco!" "Polo!" "Polo!" "Well, it's dividing our group into smokers and non-smokers." "And that's not healthy." "You're right." "Let's go have a smoke." "What?" "!" "What?" "!" "Yeah, I'm not proud of it." "Look at you two." "Smokers." "Just like the rest of us." "Whoa, whoa, whoa, whoa, whoa, whoa, whoa, whoa." "I am not a smoker." "I only smoke in certain situations." "Postcoital, when I'm with Germans-- sometimes those two overlap-- coital, birthdays, to annoy my mom, precoital, on a sailboat, the day the Mets are mathematically eliminated every year, and, of course" "wait for it, 'cause Lord knows I have-- pregnancy scares." "Why are you smoking right now?" "I'm always precoital, Ted." "You know, maybe smoking's not so bad." "I mean, at least it gets us out in the fresh air." "Yeah, and all the coughing really works my abs." "I... am... ripped!" "But, as glamorous as it was, within a week, we all hit our breaking point." "You okay, sweetie?" "Actually, baby, my throat's a bit sore." "So, I'm whapping him across the nose with the newspaper, right?" "Yeah." "And my wife says," ""Come on, you can't treat your son like that."" "I don't know." "Michael, call 911." "Oh... oh, my God." "Okay, yes, yeah, right away." "It's Marshall, by the way." "Oh, my God." "I hope Arthur's okay." "Dibs on his office if he's not." "We have to quit smoking." "Honey, you said a mouthful." "I wish I had never started." "I mean, I think back to myself at 13 years old." "If I could only go back to that moment..." "I hate that little bastard." "Me, too." "Okay, that's it." "Let's quit." "Let's..." "Let's do it." "Well, I am proud of you guys." "I have heard how difficult it is for smokers like yourself to quit, so, on behalf of nonsmokers," "I salute you, and I am here to help." "So, hand in your cigarettes, and I will get rid of them one at a time." "You're quitting, dollface." "I know I don't normally call you dollface, but it kind of works in this voice." "Dollface." "Hey, guys." "Hey." "Uh, I was just wondering, um, is anyone else interviewing the mayor tomorrow on TV, or is it just me?" "Hey, that's great." "Whoa!" "Hey!" "Yeah, Don can suck it while I suck this." "Light me, Marshall." "Actually, um, we've decided that we're all quitting smoking." "That's fantastic." "I'm sick of you guys bumming my cigarettes." "No, come on, Robin." "We-we can't do it unless we all do it together." "No." "You can sleep with Marshall." "Oh, God, Lily, no." "Sorry, baby, you got to take one for the team." "I-I don't want to sleep with Marshall." "I've seen the looks." "Right." "I can't quit right now." "Not before the biggest interview of my life." "It's-it's too stressful." "It's too stressful!" "Let's just have one more." "Give me a cigarette!" "No, wait!" "Robin, Robin, think about this for a second." "Bloomberg is the antismoking mayor." "Do you really want to show up to that interview smelling like smoke?" "It'd be like interviewing a vegetarian smelling like a McRib." "Really?" "Like I'm not going through enough right now?" "Look, you're quitting." "We're all quitting." "Fine." "I'll quit." "Great." "Great." "We just have to get through the first 24 hours." "After that, it's a cakewalk." "Barney, do you have to bite your nails so loud?" "I'm not biting my nails." "I'm trying to suck the leftover nicotine out of my fingertips." "Marshall, can you pass the onion rings?" "What, you got dinosaur arms?" "They're right there." "What do you think cigarettes are doing right now?" "You think they're thinking about us?" "Dude, if you don't stop tapping your foot, it's coming off." "Oh, my God, Ted, I'm so sorry." "Maybe I should move it a little bit closer to your ass!" "All right." "I am ready to do this right now!" "None of us knew what we were fighting about." "We just knew we wanted to smoke." "More than anything in the world." "It wasn't going very well for Robin, either." "Sorry I'm late." "Someone used the microwave, and the elevator stopped." "What are you doing?" "Okay, Don, Don, seriously, not tonight." "Okay, I'm a little bit on edge because I quit smoking for my interview with the mayor, so just..." "Oh, you precious little porcelain unicorn, you." "Why would you do that?" "Why?" "!" "Because I care, Don." "I-I care about the show, I-I care about my career." "Unlike you, you unprofessional jerk!" "You're-You're sloppy, you're rude, and I wish you worked half as hard as the elastic on those stretched-out underpants." "I'm starting to feel like this is getting a little personal." "No, Don, it would be getting personal if I would say that the reason you bounce from market to market is because you're a loser-- a lazy, obnoxious, loser." "The mayor canceled." "In five, four, three, two..." "Hi, I'm Robin Scherbatsky." "You think I'm a loser?" "You're' right." "I'm a loser." "But at least I've accepted it." "A plucky raccoon has been cheering up patients at a local senior center." "I used to be just like that." "Always wanting more and never getting it." "It's a dead end, Robin." "You're never going to be a network anchor." "Just like you're never going to quit smoking." "What are you doing?" "I'm enjoying a cigarette." "Oh, that'll get you there." "Oh, that's good." "You want a drag?" "Can we be professionals?" "Please?" "Yeah." "Yeah, professionals?" "You know who's working the camera right now?" "A chair." "We're on a show where we can't even get the cameraman to watch." "That's why the mayor canceled, Robin." "And that's why Mike is on a fried chicken run." "And that's why you and I can enjoy a cigarette right here on the air." "No, thank you." "Why?" "Because of our millions and millions of impressionable viewers?" "Okay..." "If any impressionable viewers have a problem with this, please give us a call." "The number's on the screen." "Chirp, chirp?" "Chirp, chirp?" "Come on, Robin... live a little." "Oh, that must be Mike." "He always forgets-- extra crispy." "Hello?" "Robin, don't smoke that cigarette!" "Marshall?" "!" "We're all watching and we're all very impressionable." "And I swear to God, if you smoke that cigarette, we're all going to smoke." "You..." "You guys are watching?" "We sure are, sweetheart, and you look fabulous." "Oh, you guys." "You don't have to do this, Robin." "You don't have to smoke." "Resist it, honey." "Thanks for the call, guys." "Oh, she did it!" "Good for her." "We're not going to smoke." "I have a pack stashed up on the roof." "Uh-oh." "I'm awake." "And I'm smoking!" "Robin, you know how dangerous it is to wake a sleep smoker?" "It's fine." "I bought a pack on my way home." "Hey, great show, Robin." "Yeah, but that" "Don guy, what a tool." "Well, no, he actually apologized to me." "No, I mean when he stood up." "Those briefs were pretty revealing." "You should date that guy." "Yeah." "Not in this lifetime." "They were dating within two months." "But more on that later." "Hey, guys, look, the sun's coming up." "You know what right now is a perfect time for?" "A last cigarette ever." "No, I mean, a real last cigarette ever." "Damn it, let's do it." "Okay." "All right." "Last cigarette ever on, uh, on the count of three." "One..." "Two..." "Three." "We all quit for a while after that." "But it wasn't anyone's last cigarette." "But we did eventually all quit smoking for real." "Robin's last cigarette was in June 2013." "Barney's last cigarette was in March 2017." "Lily's last cigarette was the day she started trying to get pregnant." "And Marshall's last cigarette was the day his son was born." "And my last cigarette?" "Two weeks into dating your mother." "And i never looked back." "I'm sorry I hit you, buddy." "I wanted to make it up to you, by giving you this." "Wow, she's hot!" "Yeah." "Well... some day, you're going to marry her." "No way." "We're pretty lucky." "Totally." "I'll be in my tent." "Oh, no." "Wait, hey!" "No, don't, don't do that." "Well... have fun for me."

Denim blue jeans which have been faded, "stone-washed", ice washed, or sand blasted to produce a particular appearance are very popular. However, to produce the desired effect it has been necessary to utilize processes which cause substantial deterioration or degradation of the fabric. Bleaching solutions containing chlorine or actual pelleting of the garment with sand or stones to produce a fashion effect causes damage to the fabric which affects its wear life. Ozone has been used in the bleaching of cellulosic materials. U.S. Pat. No. 4,283,251 to Singh discloses the bleaching of cellulosic pulp with gaseous ozone in an acidic pH followed by an alkaline treatment. U.S. Pat. Nos. 4,214,330 and 4,200,367 to Thorsen, which are herewith incorporated by reference, describe a method and an apparatus for treatment of undyed fabrics with a ozone-steam mixture. The process is used to shrinkproof the fabric with a minimum amount of deterioration of the fabric fibers. The ozone treatment reacts with the undyed fibers and provides whiter fibers. The treatment is stated to increase subsequent dyeability and dye fastness of the garment. W. J. Thorsen et al in their paper entitled, "Vapor-Phase Ozone Treatment of Wool Garments", Textile Research Journal, Textile Research Institute, 1979, p. 190-197, describe the treatment of wool fabrics and garments with ozone and steam to provide shrink resistance to the fabric or garment. The process is based on the reaction of the ozone with the wool fibers. It should be understood that the term "dye" as used herein is meant to include any of the materials which are used to provide a color to a fabric such as conventional dyes, pigments, or the like. It should be understood that the term "ozone and steam" as used herein denotes a preferable method of the invention and is meant to include ozone alone or ozone diluted with inert gases.

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Treatment options for patients with relapsing or refractory lymphoma are limited and their prognosis is poor. The purpose of this study is to determine if allogeneic NK cells can be effective and safe to treat lymphoid malignancies. We hypothesize that Natural Killer (NK) cells infused following chemo-immunotherapy can be safely expanded in vivo with IL-2 and can provide NK cells versus lymphoma effect. Patients over 18 years of age with history of relapsed Non-Hodgkin lymphoma or chronic lymphocytic leukemia who failed at least 2 prior treatments and have HLA haploidentical donor available are eligible for this study. Haploidentical NK cells will be infused following cyclophosphamaide, fludarabine and rituximab conditioning regimen. Subcutaneous IL-2 is used to expand and activate NK cells in vivo. Importance of this trial is that in addition to using only chemotherapeutic drugs to eradicate the tumor, we propose the therapeutic infusion of allogeneic NK cells. Donor NK cells could engage into cancer cells killing more efficiently than patients own NK cells.

Comparison of continuous-wave, chop-wave, and super pulse laser wounds. Some of the latest generation of CO2 lasers incorporate features that alter the wave form. The present study was undertaken to evaluate the relative zone of coagulation in acute laser wounds created in continuous-wave (CW), chop-wave (CPW), and super pulse wave (SPW) modes. The damage from single-point impact sites and incisions was compared in a guinea pig model. Animals were anesthetized with pentobarbital, and wounds were created with a 125-mm handpiece in focus (0.2-mm spot size) on dorsal and flank skin sites with the Sharplan 743 and 1100 CO2 lasers (Sharplan, Ltd., Allendale, NJ). Point impacts of CW and CPW were compared at power levels of 5, 10, 25, 40, 60, and 80 W at time durations of 0.05, 0.1, 0.2, and 0.5 seconds. Incisions of 3.0 cm were created at 25 W in CW, CPW, and SPW modes. Histologic sections stained with hematoxylin and eosin and Van Giesen elastin stains were evaluated by a single observer (R.J.L.). Zones of coagulation for the point-impact study varied from 79 to 257 +/- 66 (SD) micron in width with no significant differences between any of the wounds. Greater thermal damage (coagulation) occurred as the time interval increased. The zones of coagulation in the incision study were 309 +/- 83 (SD) micron for CW, 238 +/- 51 (SD) micron for SPW1 (743), 260 +/- 79 (SD) micron for CPW, and 194 +/- 56 (SD) micron for SPW2 (1100). These results are significant to the P less than 0.01 level.(ABSTRACT TRUNCATED AT 250 WORDS)

The Arabidopsis arenosa complex is closely related to the model plant Arabidopsis thaliana. Species and subspecies in the complex are mainly biennial, predominantly outcrossing, herbaceous, and with a distribution range covering most parts of latitudes and the eastern reaches of Europe. In this study we present the first comprehensive evolutionary history of the A. arenosa species complex, covering its natural range, by using chromosome counts, nuclear AFLP data, and a maternally inherited marker from the chloroplast genome [trnL intron (trnL) and trnL/F intergenic spacer (trnL/F-IGS) of tRNALeu and tRNAPhe, respectively]. We unravel the broad-scale cytogeographic and phylogeographic patterns of diploids and tetraploids. Diploid cytotypes were exclusively found on the Balkan Peninsula and in the Carpathians while tetraploid cytotypes were found throughout the remaining distribution range of the A. arenosa complex. Three centers of genetic diversity were identified: the Balkan Peninsula, the Carpathians, and the unglaciated Eastern and Southeastern Alps. All three could have served as long-term refugia during Pleistocene climate oscillations. We hypothesize that the Western Carpathians were and still are the cradle of speciation within the A. arenosa complex due to the high species number and genetic diversity and the concurrence of both cytotypes there.

The present invention relates to a device for both holding a pressurized container, such as a spray can, and for actuating the valve of the container to dispense its pressurized contents. More particularly, the present invention relates to an improvement in such devices, whereby these devices can remain attached to a spray can with much reduced risk of an inadvertent actuation of the valve. Spray can holding and actuation devices are well known in the art, as exemplified by the following U.S. Pat. Nos.: 2,877,934-- Wallace; 3,172,582-- Belpedio; 3,189,232-- Joffe; and 4,089,440-- Lee. Further examples of such actuation devices are disclosed in the following British patent specifications Nos.: 1,163,978; 1,343,881; 1,487,719; 2,001,706 (published application); and 2,038,952 (published application). Of the prior art spray can actuation devices, one of the more popular types has the general configuration of a pistol, as particularly exemplified in U.S. Pat. No. 4,432,474-- Hutchinson et al. These pistol-shaped devices typically include a body that has a pistol-grip handle, and means on the front of the body for removable attachment to the top of a spray can, of the type having a push-button valve. The body carries a valve actuation member that is operably linked or connected to a trigger, the latter being situated with respect to the handle in a manner similar to the trigger of a pistol. The linkage between the actuation member and the trigger is such that when the trigger is squeezed or depressed, the actuation member is brought into operable engagement with the push-button valve, thereby actuating the valve to dispense the contents of the container. While the prior art spray can actuation devices have added greatly to the convenience and safety of using spray cans, such devices typically lack any effective mechanism for minimizing the possibility of an inadvertent actuation of the spray can valve when a spray can is held by the actuation device, and, especially, during the process of attaching the device to the can. Accordingly, the user must take particular care to prevent the trigger from being inadvertently depressed when using such devices. The need for such care makes these actuation devices less convenient to use, thereby detracting from their utility. There has thus been a long-felt, but as yet unsatisfied, need for a safety mechanism that can be readily adapted to the prior art spray can holding and actuation devices, and that greatly reduces the possibility of inadvertent actuation of the spray can valve.

The present invention relates to a method for the controlled addition of an additive to the fuel supply of a vehicle internal combustion engine. Such an additive supply system is particularly useful, for example, with a diesel engine equipped with an exhaust particulate filter, which can be burned free more effectively by the addition of a fuel additive. Additive metering of this kind is known from DEC-36 26 419, in which a check is made every time the vehicle remains stationary for a predetermined time period as to whether an increase in the fuel level occurs. If an increase is detected, it is treated as an indication of an addition of fuel, and consequently an addition of additive proportional to the increase in the fuel level is performed. In this method, the addition of additive can be carried out while the vehicle is stationary. However, since the interior noise level while the vehicle is stationary is usually extremely low in vehicles with a high level of finish, even with the engine running, the noise caused by addition of additive (the pump delivering the additive to the fuel) is often considered to be an unusual undesired noise. It is an important object of the present invention to provide an improvement particularly in this regard. It is a further object of the invention to eliminate or at least minimize measurement errors, which can occur due to a tilted position of the vehicle during refuelling if the level comparison measurements have not been taken exclusively in the same position of the vehicle. This complex of problems is solved according to the invention, in which measured values for the fuel level, averaged continuously from individual measured values for a certain period of time, are in each case compared to one another successively. That is, the last average value is compared to the penultimate average value, while the vehicle is in motion, the driving condition being detected by a speed sensor (known per se). Any difference which exceeds a certain predetermined tolerance level in the course of this comparison is evaluated as a corresponding increase in the fuel volume, and thus causes an addition of additive proportional to the increase in the fuel supply, by means of a pump. It is not necessary for the vehicle to be stationary in this method. On the contrary, it would be possible to refuel the vehicle during driving, in which case the addition of additive would be carried out in the same manner. In the method for the addition of additive according to the invention, because level measured values averaged over a plurality of time intervals are used for evaluation only during driving, metering can necessarily only occur during driving. This has the advantage that, due to the higher noise level in the interior of the vehicle in driving operation (compared to that when the vehicle is stationary), the noise emanating from the metering pump is either imperceptible to the driver, or is at least not perceived as an annoyance. To ensure that the noise of the metering pump is not troublesome in the interior of the vehicle, its activation is also made dependent on the attainment of a predetermined driving speed. Incorrect diagnoses due to measurements with at times differing tilted positions of the vehicle are largely eliminated by evaluating only measured values averaged over a plurality of time intervals. The individual measurements carried out only while the vehicle is in motion can, for example, be performed at time intervals of 0.01 time units/sec. About 10,000 time intervals can be used for averaging in each case. The averaged values are compared for the purpose of detecting an increase in the fuel level, the comparison in each case being between the most recent value and the immediately preceding value. After the comparison, the immediately preceding value is overwritten by the last value, which is stored until it is overwritten by a new value. It is immaterial for this sequence whether the vehicle stops in the meantime or whether the engine is switched off or not. The most recent average value is retained in the measured value storage device until, after a comparison with a new value, it is overwritten, which takes places irrespective of the result of the comparison. The result of the comparison is the only deciding factor in determining whether or not metering is to take place. In order to make metering independent of chance fluctuations of the indicated fuel level due to driving, which are impossible to eliminate with absolute certainty in unfavorable driving situations (even by averaging), a certain freely selectable measured value difference must be exceeded before metering is activated. This tolerance threshold can, for example, be determined experimentally and then set to the optimum. Other objects, advantages and novel features of the present invention will become apparent from the following detailed description of the invention when considered in conjunction with the accompanying drawings.

The impact of changes in practice in organ procurement on the satisfaction of donor relatives. In the past decade several interventions have been undertaken to close the gap between demand and supply of donor organs. Family refusal is an important factor contributing to the shortage of donor organs. The importance of the quality of communication between staff and relatives has been underestimated. It is in the frontline of practice where decisions are made and behaviour of staff is critical. The current study, undertaken to explore if any changes had occurred in the behaviour of professionals involved in organ donation, took satisfaction ratings of relatives of donors in 1995, 1998 and 2001 as outcome measures. Our results show that relatives in 2001 are significantly more satisfied than those in 1995 and 1998 about staff behaviour. Changes all relate to specific interactions between key professionals and relatives. Results indicate that future interventions may be more effective if macro-oriented and regulatory policies are combined with competence-based educational programmes.

The present invention relates to pattern inspection systems, and more particularly to a system for inspecting defects of a pattern of a land portion provided around a through-hole on a printed board. In order to meet the recent requirement for heightening the mounting density of electronic parts on a printed board, improvement for fining a wiring pattern is being made increasingly. Because difficulty is encountered to keep a high accuracy by the conventional human-eye-based inspection system, it is strongly desired to automatically perform the wiring-pattern inspection. One known approach is a defect detecting system such as is disclosed in "Machine vision techniques for inspection of printed wiring boards and thick-film circuits", J. Opt. Soc. Amer., vol 3, no. 9, pp. 1465-1482, September 1986, written by J. L. C. Sanz and A. K. Jain. The conventional wiring pattern inspection techniques are generally classified mainly into the so-called design-rule system and comparison system. Of these conventional wiring pattern inspection techniques, there is a promising system which is arranged to detect a defect of a wiring pattern by contracting or expanding bi-level image data before performing the thinning process. This system will be described hereinbelow with reference to FIG. 1 where (a) to (d) are illustrations for the procedure of detection of shorting defect and (e) to (h) are illustrations of the procedure of detection of projecting defect. First, in (a) of FIG. 1, a point a represents a non-defective portion, and points b and c respectively denote fatally defective portions accompanying the possibility of line-width abnormality or disconnection. In a first step, a contraction process (erosion process) of the image is performed so that a defect appears at the point b as disconnection as illustrated in (b) of FIG. 1. This contraction process is for scraping the image by one pixel from its circumferential portions to overstate defects of the pattern, thereby causing the defect to appear as the disconnection. A second step is then performed so as to effect the thinning process of the pattern up to one pixel width as shown in (c) of FIG. 1. This thinning process is for repeatedly scraping the image by one pixel from its circumferential portions so that the width of the pattern is fined to cause the pattern to be shown by fine lines (having one pixel width, for example). Thereafter, a third step is for deciding that the 3.times.3 local areas (indicated by the square boxes) are in the disconnected states as illustrated in (d) of FIG. 1, thereby detecting the disconnections of the points b and c. At this time, the states of the junction points (indicated by the circles) between the terminal portions and the wiring pattern are also detectable. This defect detecting process is effected by scanning 3.times.3 logical masks and by referring to look-up tables. Furthermore, a description will be made in terms of defects due to projections. In (e) of FIG. 1, let it be assumed that the points b and c respectively show fatally defective portions accompanying the possibility of the line-width abnormality and short and the point a is a non-defective portion. A first step is executed so as to perform the expansion process by a predetermined size to generate a new connected state at the point b as illustrated in (f) of FIG. 1. Generally, the expansion process is for expanding the image by one pixel toward the outside, thereby causing the point b to enter into the short state. Subsequently, the thinning process is performed as a second step so as to fine the pattern as shown in (g) of FIG. 1. Thereafter, the 3.times.3 logical mask scanning process is executed as a third step so as to decide that the 3.times.3 local areas (indicated by the square boxes) the line-fined image are in the connected states as illustrated in (h) of FIG. 1, thereby detecting the shorts at the points b and c. With this process, the states of the junction points (indicated by circles) between the terminal portions and the wiring pattern are also detectable. Here, the technique of the image process such as the thinning process, expansion process and contraction process is generally known as exemplified by "Elements of Image Recognition" published by Ohm Sha. There is a problem which arises with such a wiring pattern inspection system, however, in that, in the case of inspecting a printed board having through-holes, there is the possibility that the pattern of the land portion (provided around a through-hole and electrically coupled to a wiring pattern on the printed board) is cut so that the under-width of the line (insufficiency of the line-width) of the land portion can be detected in error when the contractions for both the conductive portion and land portion are made under the same condition. This is caused by the fact that the pattern-width references of the conductive portion and the land portion are different from each other.

The present invention relates to the baking of semiconductor wafers and more particularly to apparatus for performing such a baking in a vapor sheath which both treats the wafer and removes heat from the environment. While most baking treatments of semiconductor wafers are typically performed in batch furnaces or in large ovens through which the wafers are transported on belts, it has also been proposed to bake semi-conductor wafers by means of small local heaters which may be incorporated, on an in-line basis, in a continuous semiconductor fabrication line. For example, two different forms of hot plate constructions, for different purposes, are disclosed in copending, coassigned U.S. patent application Ser. Nos. 263,928 and 373,978. In each of these constructions, however, the process is, to some extent, open to the environment and, accordingly there is some unavoidable heat loss. As is understood by those skilled in the art, semiconductor fabrication is inherently a precision process and it is typically desired to carefully control all parameters affecting each of the various process steps. It is therefore highly undesireable to have a disruptive heat source located within the process area. It has also been found advantageous to perform certain reactive treatments of the wafers simultaneously with the baking and the prior art in-line systems do not facilitate such treatment. Among the several objects of the present invention may be noted the provision of apparatus for performing in-line baking of semiconductor wafers; the provision of such apparatus which does not release unacceptable quantities of heat into the environment; the provision of such apparatus which sheathes the baking semiconductor wafer in the controlled vapor stream; the provision of such apparatus which performs reactive treatment of the wafers during baking by vapor supplied to the wafer surface; the provision of such apparatus which prevents release of reactive vapors into the environment; the provision of such apparatus which will treat wafers under precisely controllable and repeatable conditions; the provision of such apparatus which is not wasteful of reactive constituents; the provision of such apparatus which is highly reliable and is of relatively simple and inexpensive construction. Other objects and features will be in part apparent and in part pointed out hereinafter.

Conflict management styles among Iranian critical care nursing staff: a cross-sectional study. Conflict among nurses has been recognized as an extremely important issue within health care settings throughout the world. Identifying the conflict management style would be a key strategy for conflict management. The aim of this study was to evaluate the prevalence of conflict management styles and its related factors among Iranian critical care nursing staff. In a descriptive cross-sectional study, a total of 149 critical care nurses who worked in the critical care units of 4 teaching hospitals in Sari (Iran) were evaluated. A 2-part self-reported questionnaire including personal information and Rahim Organizational Conflict Inventory II was used for data collection. Although Iranian critical care nurses used all 5 conflict management styles to manage conflict with their peers, the collaborating style was the most prevalent conflict management style used by them, followed by compromising, accommodating, avoiding, and competing. Male gender was a predictor for both compromising and competing styles, whereas position and shift time were significant predictors for compromising and competing styles, respectively. Based on the results of this study, nurse managers need to take these factors into account in designing programs to help nurses constructively manage unavoidable conflicts in health care setting.

Barbecue grills are very widely used today. Presently, one of the most popular grills is manufactured by the Assignee of the present invention WEBER-STEPHEN PRODUCTS COMPANY. This barbecue grill is a kettle-type grill and consists of a generally semispherical bottom bowl that has a circular open top with a cooking grate slightly below the upper rim of the bowl. A generally semiellipsoid top cover can be placed on the bottom bowl. Also, the bowl is supported on a tripod leg arrangement. Barbecue grills that are designed for burning charcoal as a fuel have a charcoal grate for supporting the charcoal below the cooking surface. Both the bowl and cover have vent openings to provide the necessary oxygen for combustion of the charcoal while the cover is closed. One type of barbecue kettle that has received very favorable acceptance by consumers is disclosed in U.S. Re. Pat. No. 33,091. U.S. Re. Pat. No. 33,091 is owned by the Assignee of the present invention and sold under the trademark ONE-TOUCH.RTM. GRILL. In use, an individual places food items to be cooked on the cooking grate above hot charcoal. Many food items cooked on a grill can be adequately cooked on a grate. However, an individual may prefer to cook some food items on a griddle rather than on a grate. For example, pancakes, bacon, eggs, vegetables, potato hash browns and grilled cheese sandwiches are typically cooked on a griddle. Such food items may not be suitable for cooking on a cooking grate or the items may even fall through the cooking grate. Therefore, a need exists to improve barbecue grills, and more specifically, cooking grates. There is a need to provide easier barbecue cooking of some food items and flexibility to barbecue cook a variety of food items. The present invention satisfies this need. The present invention improves barbecue grills by providing a cooking grate assembly that has a removable and interchangeable cooking insert. The cooking insert can be utilized in gas barbecue grills, such as the Assignee's GENESIS.RTM. gas grill, in addition to charcoal grills. Other advantages and aspects of the present invention will become apparent after reading this disclosure and reviewing the accompanying drawings.

"Previously on Desperate Housewives." " I love you." " You're having sex with your best friend's mother?" "An affair was revealed..." "You must promise me that you won't say anything to her psycho husband." "{\pos(192,230)}A good time was brought to an end... {\pos(192,230)}" " Back off!" " Who do you think you are talking to?" "We're done here." "And a man's past was uncovered..." "We're just trying to get some info on this guy." "He just moved to Fairview," " and he's really creeping people out." " You're in Fairview?" "Why?" "Does that mean something to ya?" "Once a year, the owner of the White Horse bar would host a competition known..." "As The Battle Of The Bands." "Give it up for Cold Splash." "And young musicians would come..." "With their drums..." "And guitars..." "And dreams of stardom." "This year, those young musicians were joined by a group of middle-aged men..." "Who came with their stiff joints..." "And high cholesterol..." "And dreams of being young again..." "If only for one night." "God, look at those guys." " They're so young." " No wonder they went first." "They probably have homework." "Would you guys relax?" "Rock 'n' Roll's not just for young people." "Why are they so loud?" "Not helping." "They're really good, and, we're really old enough to be their fathers." "We may look a little old up there, and we may hit a few clams, but who cares" " we're here to have fun." " Yeah, tonight we're not the plumber and a masseur and a guy that makes pizzas." "We're a Rock 'n' Roll band." "Right, Dave?" "Absolutely." "I've gotta check with the guy about the light cues." "You're sure we're not gonna humiliate ourselves?" "I promise you it'll be a night to remember." "And it was In ways they could never have known." "Oh, my god!" "Fire!" "It's locked." "Subs by Jayson.sosweet Picard, Wisteria Team" "The next morning, news of the tragedy began to spread... {\pos(192,230)}Along with rumors that the blaze" "{\pos(192,230)}had been set intentionally." "{\pos(192,230)}It wasn't long before the police began" "{\pos(192,230)}using the word "arson"..." "And someone was taken into custody." "The Day Before" "Look at my little girl." "{\pos(192,230)}Isn't she adorable?" "I missed her so much." "{\pos(192,230)}" " I can't wait to meet her." " Not yet." "{\pos(192,230)}I wanna give her new boyfriend the once-over." "{\pos(192,230)}He's as cute as she said... {\pos(192,230)}Nice smile, and look at that hair" "{\pos(192,230)}Don't you just wanna run your fingers through it?" "{\pos(192,200)}Fortunately for you, no." "{\pos(192,210)}I'm very good at first impressions." "{\pos(192,210)}I'm gonna like this guy." "{\pos(192,210)}Why is the cab driver handing Julie's boyfriend money?" "{\pos(192,210)}Why is Julie's boyfriend getting back in the cab?" "{\pos(192,230)}And why is the middle-aged cab driver kissing Julie?" "{\pos(192,230)}" " I think what's going is..." " I know what's going on." "{\pos(192,230)}Let me enjoy my denial." "Honey, I'm home." "You wouldn't believe the traffic..." "Hello, Grabielle." "{\pos(192,230)}Virginia came by to say hello." "Isn't that a nice surprise?" "I have news I wanted to share." "You don't seem happy to see me." "{\pos(192,230)}Maybe that's because the last time we spoke," "{\pos(192,230)}you called me a greedy bitch, and I called you a scary old hag." "{\pos(192,230)}Weren't we a fine pair of hotheads." "{\pos(192,230)}But what family doesn't have its squabbles?" "{\pos(192,230)}Family?" "!" "You had Carlos fired." "That was a terrible misunderstanding." "{\pos(192,230)}And she straightened it out, and I got my job back." " Isn't that nice?" " Delightful." "{\pos(192,210)}Now leave before there's a terrible misunderstanding between my foot and your ass!" "C{\pos(192,210)}an I see you in the kitchen..." "Now?" "{\pos(192,210)}Save your breath." "There is no way we're letting grandma" " screw-loose back into our lives." " She put us in her will." "{\pos(192,210)}Oh, my god!" "That woman is crazy." "Is she crazy or just desperately lonely?" "{\pos(192,210)}" " I don't care." " All she wants is some human contact... {\pos(192,210)}To hang out with us on the occasional weekend, maybe a holiday or two." "{\pos(192,210)}Right, and in exchange, when she kicks the bucket, we wind up with a lamp." "I'm sorry, Carlos." "{\pos(192,210)}We're the sole heirs of her entire fortune." "And her blood pressure is 220/90." "{\pos(192,210)}Virginia!" "Why can't I stay mad at you?" "{\pos(192,210)}All right, then, we'll see you soon." "{\pos(192,210)}The reporter's almost here." "I am so nervous." "{\pos(192,210)}Why?" "You've done lots of interviews." "{\pos(192,210)}That was all local." "This is "The New York Dispatch."" "{\pos(192,210)}If this goes well, my cookbook could be on the front page of their weekend style section." "{\pos(192,210)}What did you do to your hair?" "{\pos(192,210)}I've never seen it look so thick and lustrous." "I'm already planning to say nice things about you." "{\pos(192,210)}Good." "I can check that off my list." "{\pos(192,210)}" " When's the reporter coming?" " Any minute." "{\pos(192,210)}Oh, my gosh." "Don't you look sharp today?" "Don't worry." "I won't tell her I'm gay." "Check and check." "Do you know anything about this reporter?" "{\pos(192,210)}Only that her name is Sandra Birch." "We spoke," "{\pos(192,210)}- and she seemed very nice." " She isn't." "I went online and pulled a bunch of her articles, and a lot of them are complete hatchet jobs." "{\pos(192,200)}"A deeper look suggests something darker, something more ominous," "{\pos(192,210)}"a woman whose perky surface conceals a deep," "{\pos(192,210)}"almost demonic thirst for power."" "{\pos(192,210)}I doubt Betty White saw that coming." "{\pos(192,210)}If this woman tanks you, I could kill sales of the book." "{\pos(192,210)}You're gonna have to figure out a way to handle this." "Knock, knock?" "I'm looking for Bree." "You must be Sandra." "What a sharp outfit." "{\pos(192,210)}And look at that hair..." "so thick and lustrous." "You got a minute?" "{\pos(192,210)}I do." "{\pos(192,210)}Why do I have a sense you're gonna take it away from me?" "{\pos(192,210)}Porter got Anne Schilling pregnant." "Mom, are you okay?" "{\pos(192,210)}Yeah, I'm great." "That it?" "{\pos(192,210)}No." "There's more." "{\pos(192,210)}They're planning to run away." "Your minute's up." "Aren't you gonna go talk to him?" "I have to talk to someone else first." "Remember when you left that soda can on the coffee table, and it left a ring, and I yelled at you," "I take it all back." "And we always sell out, so I want the band there by 6:00." " Any questions?" " Sounds good." " When are we on?" " Second." "You got the primo spot as a favor to my wife." "Since she rented you the space, she feels like part of the band." "Rock on, Anne Schilling." "If she requests "Free Bird," we're doing it." "I saw Porter at my house the other day." "He and Kirby were shooting hoops." "I can't believe how big he's getting." "They grow up fast." "Little too fast." "Hey, doc, I know I owe you a phone call." "I'm gonna cut to the chase." "Are you in Fairview?" "What?" " Where did that come from?" " Doesn't matter where it came from." "Are you in Fairview?" "I don't know what brought this on, but I'm really busy right now." "I'll call you tomorrow." "I promise." "And we can talk about it then." "Excuse me." "Could you tell me how to get to Wisteria Lane?" "So there we were, huddled under this broken umbrella, and..." "He just kissed me." "It was so romantic." "She's skipping the part where one of the spokes got me in the eye." "I'm gonna take your suitcases upstairs." "I'll come with you." "I need to check my e-mail." "Be right back." "So, Susan..." "I'm sensing that, you're a little freaked out about my age." "When your 24-year-old daughter calls you and tells you she's bringing home a boy from college, you sort of expect it to be," "a boy." "I just want you to know that we didn't start dating until after the semester was over I don't date students." "That's a rule with me." "And a damn good one." "Although strictly speaking, I suppose my third wife was my teaching assistant, but she was really more of my employee than my student." "Your what?" " Student." " Before that." " Employee." " Before that." "Third wife." "That's the one." "So you've been married three times?" " Didn't Julie tell you that?" " I don't believe so." "Although I may have blacked out after she told me you were 40." "So how does a man your age get married and divorced three times?" "My first wife and I were only married a few months, so," " I almost don't like to count it." " Did someone throw rice at you?" "It counts." "Is this upsetting you?" "I thought you'd understand." "Julie said you'd been divorced yourself." "Only twice." "Two." "Small number." "Much smaller than three." "And my first cheated on me, so that doesn't even count." " Did someone throw rice at you?" " Shut up." "You and I both know that sometimes it just doesn't work out." "That's true." "And besides, it's different with Julie." "I love her so much." "It's very important that you know I take my commitments seriously." "Why?" " Oh, my god." " Lloyd, come here." "I can't find my cell phone charger." "Please, don't say anything." "I want it to be a surprise." "Thanks..." "Mom." "And this is my own little kitchen." "I'm pretty sure my husband's here somewhere." "Dear, are you decent?" "In here, love." "Nice to meet you." "I've had the most delightful time with your wife and stepson." "Your home is stunning." "You cannot run a business and do all this, too." "Tell me you have a housekeeper." "Why would I pay someone to do work that gives me such joy?" "Who wants a little snack?" "The idea was for me to spend a typical day with you." "So this is legit?" "You're really this Donna Reed housewife from the '50s?" "You say that like it's a bad thing." "I think that decade had a lot to recommend it." "People had values then..." "Values this family strives to uphold." "But not everyone can keep a perfect house for a perfect family with perfect food and perfect flowers." "Of course they can." "If they read my book, that is." "Truth be told..." "I'm far from perfect." "Only yesterday, I burned a whole tray of biscotti." "And to think, I was worried about finding a lead." "Andrew, please." "The machine can get it." "We never answer the phone while entertaining." "So rude to one's guests." "May I pour you some more tea?" "This is Mr. Jones for Orson Hodge." "Due to vacation schedules, I'll be filling in for your parole officer." "Give me a call, please." "So, Mr. Hodge..." "You've been to prison." "Now can I be gay?" "Kirby, is that you?" "I thought you went to the movies." "Are you really pregnant?" "Yes." "A couple of months back, Warren and I..." "We fought." "I was pretty banged up, and..." "Porter came by looking for Kirby, and..." "He was so..." "Kind and..." " And gentle." " Don't." "Don't try and justify this." "This is sick." "You are sick." "Your son..." "Loves me." "And I love him." "And you know what?" "I'm glad I'm having Porter's baby." "Damn." "Not exactly what a husband wants to hear coming in the door." "I suppose dinner's not ready, either." "Warren, I'm sorry that..." "Thank you." "I'm gonna have to ask you to leave." "Don't go." "I need to talk with my wife right now." "I'm sorry for any pain this has caused your family, Mrs. Scavo." "Damn it." "You think you can humiliate me?" "!" "You piece of filth!" "Get off of her!" "I'm calling the police!" "Stay out of this!" "Just so you know, I hit back." "Call the police." "I'd love to hear her explain her way out of statutory rape." "You don't live here anymore." "Oh, my god!" "Thank you..." "For coming back." "Here we are, boys." "Are you psyched or what?" "I feel like I'm gonna puke again." " You guys Cold Splash?" " Yes, sir." ""Sir"?" " We're Blue Odyssey." " I can see that." "After the gig, we're having a party at our manager's loft." " You guys should come." " Abso-tively." "We just gotta check with our wives." "Why were you talking to that woman?" "She just walked up and asked if we knew you, wanted us to confirm a bunch of rumors." "What kind of rumors?" "Just..." "Stuff she'd heard around the neighborhood." "Were you really a boozehound?" "I wish I'd have known you then." "We'd have been such good friends." "She seemed to know an awful lot about you." "Key word..."awful."" "I cannot let this happen." "I have to find her." "She's gonna be at the Battle Of The Bands tonight." " Why?" " She wants to hear Orson, and I quote," ""sing harmony with the guy he tried to kill."" "Dear god." "This woman is determined to make my life sound ten times worse than it actually is." "Was your first husband really into S and M hookers?" "And you wonder why we're never invited anywhere." "Girls, mommy's leaving." "I love you!" "I'm planning on having a massive hangover, so keep the girls up late so we can all sleep in." "My, don't you look festive." "What are you doing here?" "What do you mean?" "We're going to watch Carlos' band play." "You invited me this morning, remember?" "What I remember was you asking me to the movies tonight, and me saying I couldn't because I was going to watch Carlos' band play." "You got invitation out of that?" "I'm here now, dear, and I have this lovely limo." "So come on." "We'll ride over to the club in style." "Here's the thing." "I'm supposed to go with my girlfriends." "Please, I was so looking forward to this." "Don't make me go all alone." "I guess we're all going to the same place." "I'll just see my friends there." "Goody!" " Where's Anne?" " She's asleep." "She's fine." " What happened?" " I went over to talk to Anne about recent developments." " You went to her house?" " Yes, I did." "I had to talk to Anne." "I didn't know that her husband was there, and he overheard us and..." "The doctors say she's gonna be fine." "Where are you going?" "Damn it!" ""Tonic water, bourbon, ketchup." This is your grocery list?" "There's got to be something else on Dave's phone bill that'll help us." "There isn't." "Don't get broccoli." "It is not your friend." "You're telling me that you cross-checked all those other numbers," " and there was nothing?" " Squat." "The key is this doctor guy." "Maybe we should just bite the bullet and go to Boston." "Maybe we can get more out of him face-to-face." "You wanna go to a rock show tonight?" "Me?" "With you?" "I'm a little out of your league, but if it'll get you there, sure." "I don't think I can, but thanks." "Here, in case you change your mind." "And then I noticed that Maria's pockets were stuffed with silverware." "I'm telling you, it's impossible to find good help these days." "You'll know soon enough when my cholesterol finally gets the better of me." "Don't talk like that." "You want a cheeseburger or something?" "That has got to stop." "I'm gonna do something." "Why?" "Julie's a grown woman." "She's a grown woman with stars in her eyes who's in love with a 3-times loser." "If she wants to accept his proposal, that's her business." "But in the meantime, you're not gonna ruin his surprise." " Aren't I?" " No." " Aren't I?" " No." "You're right." "I'll stay out of it." "Where is the little girls' room?" " Why did that guy hand you a CD?" " Your name isn't Julie, is it?" "Why?" "He wants me to play a song." "I guess he's gonna propose to his girlfriend." "Tonight?" "!" "Isn't that lovely?" "Hey, you two." "What's going on?" "Nothing." "What's going on with you?" "I just love this song." "And Jackson doesn't like to dance, so..." "Isn't this fun?" "It was." "Reminds me of being young and single." "I wish I'd never given up that." "I don't want to sound rude or anything, but this is really a moment that's meant for two." "Right." "You mind easing away so I can dance with my daughter?" "What are you doing?" "I'm..." "Just movin' to the music." "You're coming with me." "All right!" "But no matter what he asks you, promise me you'll say "no."" "Lloyd, I'm sorry." "I can't help it." "I don't want my daughter" " to be someone's fourth wife." " Wife?" "Were you gonna ask me to marry you?" "Were we not clear on that by now?" "You can't be serious." "We've only been dating three months." "I know, but I have such a good feeling about us." "Right, better feelings than you had about wives one, two and three?" "You are very sweet, but," "I'm not getting married..." "Ever." "What do you mean, "ever"?" "We'll talk about this later." "I just really need a moment to myself." "Thank you." "Bree, darling." "Spare me your "darling."" "I know you've been trying to dig up dirt on me." "Just doing my job." "And frankly, I didn't have to dig all that hard." "I wrote a cookbook..." "Meatloaf, pot pies, peach cobbler." "Why are you trying to crucify me?" "Because it's not a cookbook." "It's a "look how great I am" book..." "One designed to make every woman who reads it feel like a failure if she doesn't measure up." "What you're selling's a total sham." "But it isn't, because I don't think I'm great." "I have fallen down more times than I can count, just like so many other housewives out there." "We're all just barely holding on, and we all think that we're alone." "So maybe you're right." "Maybe it isn't a cookbook." "It's a lifeline from me to those other women, because I want them to know there's always a chance to get something right." "Even if it's just a casserole." "Why didn't you just tell me that right up front?" "That's an angle I can work with." "I got some good news today." "I've been speaking with the headmaster at Greenbrier country day school, and I got them to reserve two spots for the girls." "They start next term." "Thanks, but the girls already have a school." "I know..." "A public school." "This is a good school." "They're happy where they are." "They love Fairview." " Besides, Greenbrier's an hour away." " So I'll get them a driver." "That would be a real treat for them." "I want them to be close by." "They could need me..." "get sick or something." "That's what school nurses are for." "Dear, this is a decision I feel very strongly about," "I'm afraid I have to insist." "Excuse me." "You don't get to insist on anything when it comes to my daughters." "I think, given the extent of my investment in this family," "I should have some say." "I'll just give you some time to think about it." "I don't need any time to think about it." " Keep your money." " You're being reckless." "You know something?" "I like money." "I like it a lot." "A couple years ago, you could've bought me with that big fortune of yours." "But I'm a mom now, and I make the decisions for my kids." "And that is something that cannot be bought." "I can make a decision, too." "I can call my lawyer and take you out of my will." "And that is your right as a crazy old rich lady." "Thank you." "Screening your calls now, Dave?" "Let me guess." "You can explain everything." "I'm really, really sorry, doc." "You changed your name and didn't tell me." "You're living in Fairview..." "The one place you swore you wouldn't go." "I didn't change my name to be deceptive." " I just wanted a fresh start." " Fairview is not a fresh start for you." "My wife Edie... she's from here, and she really wanted to move back and I said okay." "Did you tell her your history?" "Did you tell her why it's not healthy... or safe," "for you to be here?" "She knows everything, and I'm in a really good place right now." "But..." "Can we talk about this after the show?" "These guys..." "They're my friends, and they're depending on me." "The moment you're finished playing." "Let's start this year's Battle Of The Bands with our first group." "Give it up for Cold Splash!" "Spare me the apology for butting into my life for the millionth time." "What is this about you never getting married?" "Why would I?" "If there's one thing I've learned from your experience, marriage is a joke." "I believe in marriage." "Why?" "First there was dad, who left you for his secretary, and then Mike..." "He was the love of your life, and it still went to hell." "Honestly..." "Just tell me what the upside is." "You're way too young to be this cynical." "I am not cynical." "I'm realistic." "I'm just trying to protect myself." "Putting a wall around your heart doesn't protect you." "It just keeps people out." "I learned that the hard way." "Now with Jackson..." "I remember that I like feeling hopeful." "I like believing in "happily ever after."" "I really wish that you felt that way, too." "Sorry about the tip, but I just lost $50 million." "Have you seen Porter?" "No, I haven't." "Is he supposed to be here?" "If you see him, please tell me." "Thanks." "Come on." "Tonight, we're not a plumber and a masseur and a guy that makes pizzas." "We're a Rock 'n' Roll band." "Right, Dave" "Absolutely." "I'm gonna check with the guy about the light cues." "Hey, doc." "He's in your band?" "!" "Oh." "I know." "It sounds crazy, but we've worked through everything." " It's cool." " No." "This is too dangerous." "I need to speak to him right now." "You just have to trust me." "Now, Dave." "I speak to him right now..." "Or I call the police." "You win." "Come on." "I hope you realize..." "I'm only doing this because I want to help you." "I genuinely care about you." "I know you do, Dr. Heller." "And I like you." "Actually, I like you a lot." "I'm sorry." "I know this is gonna sound crazy, but I can actually smell our fear." "If I could see where the exits are, I'd run for 'em." "I can't believe we let Dave talk us into this." "By the way, where is Dave?" "Where are you going?" "The guys are about to start." " Bathroom." "Back in a sec." " The men's room's packed, but there's an employee bathroom back there." "Thank you." "Is that the bathroom?" " I think that's it there." " Okay, thanks." " We're up." "Where the hell is Dave?" " Sorry." "We thought you ditched us." "Where were you?" "Needed a little liquid courage." "Come on, boys." "Let's do it." "Ladies and gentlemen, the Battle Of The Bands is back, so please give a big welcome to Blue Odyssey." "Hey, Warren." "Get up, you little basrd!" " Don't you touch him!" "Go home now!" " I know what you did to Anne." "Better listen to your mommy, little boy." "Go home." "You're dead." "I don't care what it takes." "You're dead." "Stop it!" "Go on!" "Hitting women and children?" "You must be so proud." "Lock that door." "What were you thinking?" "You could've gotten hurt in there!" "You are responsible for this." "Whatever happens is your fault." "Oh, my god!" "Fire!" "What's happening?" " Jackson, he's in the bathroom." " There's an exit there." "He'll get out." "Come on." "We have to go now." "Open up!" "Gaby!" "Your friend!" "Crap!" "Come on." "Let's get you out of here." "Let's go." "Since I'm saving your life and all, you wanna think about maybe keeping us in your will?" "It was worth a shot." "It's locked." "Look out!" "Quit pushing!" "Come on." "No, I gotta make sure everyone gets out of here." "Go!" "Don't push!" "One at a time!" " What are you doing?" "Get the hell out!" " Jackson... he's still in there." "He's in the bathroom." "I'll get him." "Go." "Just go." "Get out!" "Go!" "Thank god." " Where's Mike?" " I don't know." "I didn't see him." " Is he still in there?" " Yeah!" "He went in there to find you." "Mike's still in there?" "Dave, no!" "Mom!" "Dad." "I told you to go home." "What are you doing here?" "You son of a bitch!" "You did this!" "Stay away from my kid!" "Your kid burned down my club." "Do you think he's still in there?" "I didn't see him." "My husband's still inside." "You've gotta go back in there!" "I'm sorry." "That roof is about to collapse." "Please get back." "Someone's coming!" "Hang in there." "I'm not done with you yet." "There was a fire last night in Fairview." "If you open up your morning paper, you can read about those who survived..." "And those who were injured..." "Those who barely escaped with their lives..." "And those who didn't." "You can also read about a man who risked his life to rescue his neighbor." "What you won't read about are the reasons for this bravery." "You're the one who pulled that guy out of the fire." "Can I interview you?" "And that's because..." "No one ever doubts..." "A hero."

A Wavelength-Division-Multiplexed (WDM) transmission link often includes multiple segments of transmission fiber separated by one or more optical amplifiers and other fiber optic components. Generally speaking, it is desirable that these links exhibit uniform signal transmission for all wavelengths. Unfortunately however, non-uniformity in gain and loss accumulate and eventually cause transmission errors unless the signal is equalized. Such equalization in wavelength division multiplexed systems may be achieved by a variety of means including signal pre-emphasis, fixed fiber gratings, and individual attenuators placed between wavelength routers. Each of these approaches represents a tradeoff in network operator flexibility. An approach to WDM equalization was described by the inventors of the present application in U.S. patent application Ser. No. 08/690,696 filed on Jul. 31, 1996 for an Attenuation Device For Wavelength Multiplexed Optical Fiber Communications and is incorporated herein by reference. This previous approach, involved multiple wavelength signals in an optical fiber spatially dispersed by wavelength over a row of voltage-controlled variable reflectivity modulators in which reflected (and attenuated) signals are combined into a single optical output fiber. Despite advantages of this technique, a continuing need exists in the art for equalization apparatus and techniques that provide enhanced optical performance.

Evaluation of different captive bolt lengths and breed influence upon post-stun hind limb and forelimb activity in fed cattle at a commercial slaughter facility. The objective of this study was to assess the effects of captive bolt length and breed type on post-stun leg activity in cattle. A total of 2850 Holstein (HOL) and non-Holstein British/Continental bred (NHOL) steers and heifers were observed post-stunning at a large commercial slaughter facility. A pneumatically powered penetrating captive bolt stunner was used with three different bolt lengths: CON, 15.24 cm; MED, 16.51 cm; and LON, 17.78 cm. Hind limb kicking, forelimb activity, take away belt stops, carcass swing and number of knife sticks during exsanguination were recorded for each animal from video recording. Hind limb and forelimb kicks observed ranged from 0 to 25 and 0 to 8, respectively. Analysis of post-stun hind limb and forelimb activity indicated that increasing pneumatically powered penetrating captive bolt length does not decrease post-stun leg activity. There was a higher percentage of cattle experiencing take away belt stops and carcass swing in HOL as compared with NHOL.

Smoking behavior among adolescents in Thailand and Malaysia. The objective of this study was to examine the smoking behavior among adolescents in Thailand and Malaysia. Population-based, national surveys were conducted among 1,704 adolescents between the ages of 13 and 18 from Thailand (n = 927) and Malaysia (n = 777). Respondents were selected using multistage cluster sampling. Respondents were asked to complete self-administered questionnaires. Approximately 5% of Thai and Malaysian adolescents were current smokers, while an additional 8.6% of Thai and 8.1% of Malaysian adolescents reported being beginning smokers. On average, Thai smokers reported first smoking a whole cigarette at 14.6 years old (SD = 1.9), while Malaysian smokers at age 13.9 years (SD = 2.2). More than half of Thai smokers (60.4%) reported they bought cigarettes themselves and 29.9% got cigarettes from friends. In Malaysia, most smokers (68.3%) reported they bought cigarettes themselves, only 20.7% got cigarettes from friends. Seventy-six percent of Thai adolescent smokers smoked factory-made brands as their usual brand compared to 27.7% of Malaysian adolescent smokers. Eight percent of Thai adolescents and 10% of Malaysian adolescents reported smoking hand-rolled cigarettes. Approximately half of Thais and more than 40% of Malaysian smokers reported they tried to quit smoking within the past month. The smoking prevalence of Thai adolescents is close to that of Malaysian adolescents. Factory-made cigarette consumption is an important problem in Thai adolescents and needs to be targeted.

"A PISTOL SHOT" "Hey, sled, sled!" "Get busy!" "Gerardo, you're too fast, I'm tired." " Would you like a sip?" "No, it burns too." " It can't hurt you." "Drink." " Just a sip, thanks." "Gerardo, look!" "There!" "There's a man on the ice!" "He didn't see the sign." "The ice is thin, it'll break!" "No, Gerardo, don't go!" "I don't want!" "The ice won't hold you both!" "Let go of me!" " Ouch!" " Sir!" "Come here, come here!" "Hey, Sir!" "It's dangerous." "Stop!" "Here the ice may break at any moment!" "Let's go back, it's dangerous." "Did't you read the sign?" "No." "But the ice won't hold, here!" "It'll break!" "Look!" "Wait!" "Wait for me too!" "Monsieur de Valmont, come along." "Monsieur de Valmont..." "Monsieur de Valmont, this morning you ran a great risk to warn me,.." "and I have not even thanked you." " Anyone would have done the same." "But let me express my gratitude and to introduce myself." "Andrea Anickoff." "Gerardo de Valmont." "Oh, I know very well your name, and your books as well." "I've read your latest novel, 'Faustino', and was impressed." "A fantasy, pure fantasy." "Sometimes reality exceeds fantasy." "Monsieur de Valmont, I renew once again my gratitude and my apologies." "It's odd, sir,.." "but between us 2, it's me who feels the need to apologize for this morning,.." "for my intervention, which seemed to me, maybe,.." "unwanted." " Maybe." "However, if I can be useful, I will always be at your service." "Count Anickoff, I too knew your name." "I know you as one of the Czar's most brilliant officers." "You were mentioned in Paris, among friends, by Prince Drutzky." "You know Drutzky?" " A casual aquaintance, at the club." "He spoke of you as a formidable shooter." "Count Anickoff, you just offered to return the favour..." "I'd be happy to keep my word." "Then, just answer a question of mine." "It is curiosity of a writer." "Your act this morning, has any relation with Drutzky?" "Excuse me, I was indiscreet." "I withdraw my question." " No." "I promised, and it's right." "Sit down, please." " I wouldn't want..." " Sit down." "So you met Sergio, I mean Drutzky, in Paris." "When?" "Last year, he was on mission." "Sure one can't imagine two more different friends." "Since two years, we are no longer friends." "Before, yes." "In the regiment we were inseparable, although I was nearly six years older." "We were garrisoned in the town of Borisov, in southern Russia." "Excuse me,this story brings within the explanation..." "Do not interrupt me, pray you." "It was in 1832." "Andrea!" "Andrea, allow me to introduce you to Lt. Sergio Drutzky." "He's arrived today to our regiment." "Maj. Anickoff." " Pleased." " Good evening." "So, my task is finished." "You've met all officers of the regiment." "Good evening." " Good evening." "How is this garrison, Major?" "An ancient provincial town, small." "You've seen it, no?" "You allow?" "Oh!" "Sorry." "Extraordinary shot!" "Why, a man like you, in this provincial hole?" "You find my ability at play wasted here?" "You jest!" "You're known also outside of Borisov!" "I am here to study a new system of fortifications..." "Instead, I'm here,.." "imagine, my mother wanted me away from the temptations of St. Petersburg!" "You allow me?" " Oh, please." " Gentlemen, good evening." "Have you seen how the Major plays?" " He has a really unerring eye!" "You know that he won't miss a gunshot even at 100 steps?" " Really?" "Bravo Sergio!" "A shot thrown so, by hand!" "And you spoke of the Major!" "You have an amazing ability!" "Luck, sheer luck." "Such a luck, that at times I'm ashamed of myself." "It's the third time already that you sit on the table where I'm playing." "What would be, this?" "A duel?" " It would be..." "Drutzky!" "You have yet to find accommodation!" "It's already 10:00 p.m.!" "10:00 p.m.?" "10:00 p.m., you said?" "Excuse me, gentlemen." "Going away, Andrea?" " Yes" " What's up?" "With whom did you quarrel?" "Nothing." "That lieutenant that you introduced me, Drutzky." "A silly, a fatuous..." "very unpleasant." "Yes, I understand." "Taciturn, strong-willed, tenacious." "To me, however, he seemed a cold man, selfish and petty." "Very unpleasant!" "Instead, from that day we became inseparable friends." "The very diversity of our characters united us." "He had no secrets from me, I had none for him." "That is, I had a secret for him,.." "but something that I kept secret almost to myself." "Andrea!" "Oh, here he is!" "We were all waiting downstairs." "Come, there's Alessio too." "You've been of service today?" "Yes, in the barracks." " Come meet some girls." "Fanny, Barbara, come, I introduce to you the Major." "Here, Barbara and Fanny!" " How many chevrons!" "Are you a Major?" "Yes, Major Andrea Anickoff." "Alessio, give me your arm." "Major, come?" "No, sorry, I will gladly give in our accommodation." "Here's the key,.." "but I can't." " You're going?" " Goodbye." " You don't come?" "No." "Pardon me, but.." "I can not." "Goodbye." " Goodbye." "Goodbye Andrea." " Major!" " Where does he go, away like that?" "I forgot, it's 10:00 p.m. What does that mean?" "He's very busy studying a new system of fortifications." "What fortifications?" "No one knows exactly what it is." "Fact is, at 10 pm he disappears, and spends his nights in studying." "Bravo!" "In these 3 months you've made extraordinary progress!" "I practiced a few times at the club." "The ladies there." "A bother, right?" "It took just the billiards to bring you back among us!" "I said it today to my wife and to my niece,.." ""That devil of Andrea, was at our house many times as a boy,.." "and then, was it not the passion for billiards, we'd see him no more."" "Oh, yes, of course, the ... billiards." "But how could you miss a shot so easy?" "Maybe today I rode too long, and my hand trembles a bit." "Well, we must go and greet the ladies,.." "or they'll think I just came for my passion for billiards." "Poor Andrea!" "With what face you say so!" "But tomorrow, you'll see what a game!" "Beware!" "Be composed, and with melancholy gaze!" "There is my niece who is singing." "Good evening Masha." "Did you enjoy, Aunt?" " How well you sang!" " Very good!" "What a beautiful voice!" "Very good!" " Very good, indeed!" "Andrea?" "Good evening, Andrea." "I hadn't seen you." " Good evening Masha." "Oh, but what are you doing?" "You are messing the score!" " Sorry, pardon me." "Since when you're so corteous with this brat?" "You were always intimate with her!" "Yes, then!" "But now, after we've met again..." "I'm a young lady now!" " Down with airs, chatterbox!" "When you were this tall, Andrea carried you piggyback out to the garden." "And he was a strapping young man of twenty, with the rank of aspirant." "Yes, but now he's Major." "And I too have made a career." "And I am very offended and I go to the balcony." "Andrea, the moment is propitious, if you want to slip away." "See you tomorrow evening for the usual game!" "Masha, I have come to greet you." " Are you going already?" "Yes, and I wanted to..." " See you tomorrow then." "You can't miss." "You've such a passion for the billiard!" "No, maybe I'm leaving, tomorrow." "I'm going for maneuvers near Kiev, and I'll be away a month." "But I hope to see you again." "Will you still be guest of your uncle until my return?" "Oh, Andrea, one month!" "You'll be away a whole month!" "But then, you are sorry that I leave!" "Listen, Masha..." "Of course I'm sorry!" "For my uncle!" "He was so accustomed to his games." "But Andrea, have I interrupted you?" "You wanted to tell me something?" "I ?" "Yes." "You said "Listen, Masha..."" "I wanted to tell you..." "that you sang very well." "Good evening, Masha." "So I spent the evenings." "This is what I kept secret to Sergio." "But Masha's character, to have known her as a little girl,.." "hindered me from declaring my feelings." "So I left for the maneuvers, determined to forget about it." "I had an important assignment, the Army Staff adopted my defense system, but.." "all this, meant nothing to me." "So, three weeks went by, until..." "It had been a tiring day." "The units returned to the housings,.." "while the sentinels on the hills played the "cease-fire" signal." "Here." "Major, the 2nd battalion already left the position." " Good." "Major, from the general." " Take care of it, Tukev." "An officer at this intersection, to lead the green units on Kormanecky." "What is it?" " It's a pass, for some ladies." "Ladies?" "But this is no place for ladies." "Antonietta, come here, run!" "There are horses!" "Dad, it's true that we'll meet Major Anickoff?" "Yes dear, and many other brave officers." "Maria!" "Maria!" "Have you seen Maria?" " No, dear." "Where will she be, with all this confusion?" "Come, come, come up, you have to climb!" "Maria you come, too, the observatory is up there!" "Major, here are the ladies." "Thank you, General!" "With these cannon shots, I'm so afraid!" "Come on!" "Come, quickly!" "What a beautiful day!" "After this climb, here we are at last!" " General..." "Ladies, let me introduce you Major Anickoff,.." "and these valiant officers who will host us." "What a nice view!" " My wife, Princess Caroline, and her daughter Marina." "The Baroness von Lembe, Lady Nusoff, and my niece." "Oh, sorry dear!" "I too want to be introduced!" "My pleasure!" "Major, will you show us the great maneuvers?" "And what you wear there, is the Order of St. George?" " Yes, miss." "May I look with your telescope?" " Please." " Is this it?" "But I can't see anything!" " Give me, dear." "Surely, it doesn't work." " You see...so many things!" "Want to watch too, Marina?" "I'd rather watch so, it's all so beautiful up here." "But I see everything small." "How come?" " May I, madam?" "Here, look, so." " Thank you." "Now I understand how it must be easy vanquishing the enemy!" " Really?" "And me?" "Won't you let me watch too, with the telescope?" " Yes, of course!" "Masha !" "So, these maneuvers are over, we arrived late." " Masha!" "Masha!" " Oh, excuse me." "Oh, the things you can see!" "What can you see?" " I see...a young man." "Yes, an officer, an aspirant,.." "carrying piggyback a little girl." " Where?" "There, on the lawn!" "And then farther on, another officer, who plays." "At billiard." "I get it." "You're saying nonsense to be charming with him." "Lieutenant!" "But the officer is distracted, because... on the lawn,.." "in front of him,.." "there is a peasant girl,.." "who sings..." "at the piano." "But, even the girl is distracted, and errs her song, because of the officer,.." "but he doesn't notice." "Indeed he tells her:" ""You sang very well."" "And then,...you see..." "You don't see anything else." "But, isn't it late, Aunt?" " Sorry?" " Isn't it time to go?" "It's late, Porfirio?" " Yes dear." " Then we can only thank the Major." "You're welcome." " And these brave officers." "Come, dear." "It was a great day." "Oh, thank you, Andrea." "This telescope, I'd say that it's almost miraculous." "I would like to look through it myself, to see, to know..." " To know!" "?" "To know why the girl who was singing on the lawn, at the piano,.." "came here." "But the reason is the simplest of all." "Because I have an aunt also in Kiev, and now I'm her guest in Kiev." "Maman gave me permission." "And there isn't another reason?" "Oh, you think?" "Well, maybe there is." "I love the countryside!" "Masha, when will you speak seriously?" "But I'm serious!" "I love the countryside, and I think you should like it too." "If is your order, I'll say: "I like it"." " Oh, how could I give you orders?" "For you I have all the respect that my uncle demands." "My other uncle." "But I find you much changed, Andrea." "In town you had the garrison, officers, parades..." "You awed me so much, in town!" "Here, if you hadn't that so important uniform,.." "well, I'd go for walks with you, on horseback, in the fields..." "Masha, let's go!" " Masha !" "Masha!" " What are you doing up there?" "Yes, I think if I had to live with you,.." "I would always live in the countryside, in a beautiful castle." "Major, if you insist, I'll forward your letter of resignation to the ministry." "Why, you know that you were recently proposed for advancement to colonel." "Yes, I know." "I admit I regret losing you as officer." "Come fore, don't let me shout!" "You could at least wait our return to St. Petersburg to ask, not this shack." "I don't get it." "Hundreds of officers got married." "That's your case, right?" "Without thereby ending their career." " General..." "Well, well, I hope that what you do is for your happiness." "Sign." "General, a request." "So far no one knows my decision, not even the person concerned, and..." "Yes, I understand it all, you reserve a surprise." "As to say, a wedding gift." "Sure it's a nice proof, to cut one's career..." "Don't worry, I won't tell anyone." "Sign!" "Go ahead, sign!" "You asked for it." "Sign." "Is Major Anickoff here?" " What you said, excellency?" " Where's the Major?" " What?" "Pietro, where's your master?" " Went out!" " Out?" " But is back, excellency." "Well, where is he now?" " Upstairs, excellency, upstairs." "On that terrace." "Hey, you do!" "?" " Sergio!" "Well, what's going on?" "I practice target." " And doesn't miss a shot!" "As you see, I practice quite well, right?" "I put it on the plate?" " Do as you wish." "Donato, bring the gun to Pietro and tell him to clean it." " Yes." "So then!" " Well, what happened?" "You made me rush for 15 miles!" "And I'm very happy to see you again." " Me too." "I see you don't lack appetite!" "I thought you were in Petersburg." "Aren't the maneuvers finished?" " Yes, from a week." "At last, can I know what happened?" "It happened that..." "Don't say it!" "At your orders, Colonel!" "They made you Colonel!" "They all said you had been promoted!" " No, sit, sit down." "Listen, Sergio,.." "what would you say if, suddenly, you felt free to do what you like?" "To organize walks, to have a nice house...rather, a nice castle." "Hunting, a pond for fishing, a nice stable, a nice library ..." "Living, in short, in the countryside,.." "and have no other concern but to feel happy." "Why, now, these are your worries?" "And the career, the army?" "I decided to resign." "Resign from what?" " From the army!" "I resigned." "No!" " Yes!" "To raise chickens in the countryside?" "Chickens!" "Here's something I had not yet thought of." ""Chickens"..." "By the way, Sergio, you're invited for a walk in the countryside next Sunday." "But you say!" "You really are amazing!" "To have such a career, and to end it so, to do outings and go fishing in a pond!" "Well then, I tell you one thing:" "basically, I'm glad." "Despite your bad temper, I love you." "Sure, you're right!" "You lead an absurd life: career, studies, fortifications!" "That's my opinion." "And you know what you're still missing?" "A woman!" "Oh, yeah!" "You never knew anything about these things." " Yeah." "So, you're staying until the outing?" " There will be beautiful ladies?" "I think so, there should be." "Although, I never knew anything about such things." "Sunday morning was one of those mornings.." "all the more beautiful the more rare in our country." "I was anxious to know Sergio's opinion on Masha." "But, wanting a dispassionate opinion, I refrained previously to talk of her." "Merrily we rode towards the ladies.." "who were coming on open carriages, bringing the baskets for a snack." "Mom, look up there, Andrea!" "Andrea!" " Good morning, ladies." "My dear Anickoff!" "We feared you wouldn't join us." "I too feared you wouldn't come!" "We made a long detour to show to my friend the surroundings, so we belated." "Prince Drutzky." "We heard so much of you that we already know you." "Right Sofia?" "Princess Gourville and her daughter Marina." " My pleasure." "Come Sergio, come here!" "I want you to meet a person." "Here is my friend, Masha." "Yes, I've seen him already." "Good, Galupka." " Doesn't he match the description I made you?" "Andrea!" "I imagined him much taller." "How can you judge the height, on horseback?" "Be quiet, when a lady speaks!" "I meant, more slender." "You described him as so handsome, that I thought he'd resemble you a bit." "I regret not satisfying you, miss, but who knows, I still have hope to grow up." "Sergio, let's take the shortcut, so we'll do sooner." "Where, here on the left?" " Yes, we'll find the other carriages." "Masha, I hope that, at least you, have some liking for my friend." "Certainly!" "But I don't think your friend needs your recommendations." "Why?" " I thought he was so sure of himself." "Alas!" "Before, your cousin said that I'm too short, now I'm too sure of myself." "May be!" "Yet, I'd say that in some cases, boldness doesn't fail you." "I think I understand, but please don't mistake plain naivety with boldness." "Sorry to interrupt you, but may I know what is this mysterious dialogue?" "Ask a certain gentleman,.." "who around 18:00 says he loves the solitude of the countryside." "Or a girl who around 18:00 is poetically reading on the parapet of a bridge." "Well, may I know what's this all about?" "Sorry to deprive you of the fun to tease me, but now the game is unsustainable." "Yesterday we met, me and her." " We met..." "You, have met me!" "Let me continue, please." "In rather odd circumstances." "Odd, you say?" "Imagine, Andrea, a girl, sitting on a low wall ..." "Low wall?" "It was a bridge's parapet." "It's the same." "I sat there, and..." " Reading!" " Okay, reading!" "And an individual whom I never saw or met, stops before me, and says:" ""Young lady, do you believe in love?"" "What do you think, Andrea?" " Oh, yes, yes..." "In your haste, you forget too many things." "To begin with, a stream flowed under the bridge with a enchanting murmur." "Then it was sunset, the poplars trembled with thousands leaflets..." "But, dear Sergio, you're revealing unsuspected poetic qualities." "Are you sure you did not read this somewhere?" "Actually it's something I learned in college as a boy." "But let me continue." "You held the book and watched the water run." "Yes, I had dropped the bookmark." "Rather it seemed a very poetic attitude." "Wouldn't you agree?" " Yes, sure..." "So I felt transported, and with great innocence, I asked her:" ""Young lady, do you believe in love?"." "But without any intention, I assure you." "What do you mean, "I assure you"?" "I might even be offended." "But the lady did not interpret it with the same innocence." "Annoyed, she gave me a look of hatred." "Hatred!" "You didn't deserve as much!" "A look of surprise, boredom, if you want." "Hatred!" "She sprang to her horse, spurred and disappeared." "Thus ended our meeting." "Strange meeting, isn't it, Andrea?" "Yes, strange indeed, but... but maybe, who knows, the best suited to your strange characters." "Andrea please, come here next to me." "I wanted to tell you something." "Can't remember..." "Oh, yes!" "You ever had.." "the feeling to have already been in a certain situation or place?" "Yes, maybe." "So, I heard the noise of the carriage, the bells." "Masha and your friend laughing behind..." "For a moment I felt sad,.." "as if this had already happened to me in another life, or,.." "as if this were to happen inexorably." "Isn't it true, Andrea?" " Yes, everything has to happen." "You seem distracted, Andrea." "He's nice, that friend of yours." "I must have met his mother." "But hear how he laughs, must be merry!" "His mother, was not a Dubrovsky from Orel?" "In Orel, I had some relatives." "It's two years I don't see them." "Also..." "Sergio!" "# Ring, ring, ring-around-the-rosey #" "# Ring, ring, ring-around-the-rosey Do not look beneath the blindfold!" "#" "Masha!" "You're Masha!" " Not fair!" "He could see!" "Not true, it's not true!" "I couldn't see!" " It is not fair!" "I know he could see, but I'll blindfold anyway, to show that I'm good natured." "Ouch, you're hurting me!" " It's not my fault." " What do you mean?" "If I were good at madrigals, I'd say.." "that I confuse the blindfold silk with the silk of your hair." "It's not fair!" "They had it arranged, Masha and Sergio." "Shall we make an arrangement too?" "# Ring, ring, ring-around-the-rosey #" "# Ring, ring, ring-around-the-rosey Do not look beneath the blindfold!" "#" "Why don't you sing?" "Don't you know the chorus?" "I'm afraid of being caught, Mascia knows my voice." "Change voice, singing falsetto." "Yeah, if then it remains forever, how do I give orders to the soldiers?" "Does not recognize him!" " She does, by the Order of St. George!" "Sergio, you are..." "Tea is served!" "Andrea !" "Andrea !" "Come here." "Andrea, where were you?" "I have sought you so much!" "Sit here, on my right." "You are looking for Masha for a cup of tea, right?" "I'll call her now." "Masha!" "I cannot come, I am serving tea to Sofia." "Sergio, where are you?" " I'm here, behind you." "Some tea?" " No, canapés, thanks." " Sergio, canapés." "No, you're always wrong!" "Not sweets, canapes!" "Now I'm coming to you!" "Anickoff, how old is your friend?" " Who, Sergio?" "Yes, of course." "But, kids!" " 25, 26, I think." "What a perfect day, don't you think?" "What a lovely couple they do, right?" " Sonia, Andrea,.." "a cup of tea?" " Thanks, Marina." "We expect Masha to bring it." "Marina!" " Here I am, I'm coming." "Before, you thought to have already been in a place." "Did you ever think instead, that life is meaningless?" "But life is meaningless!" "That's the beauty." "And you never thought that the only thing that fills life is hatred?" "But, Andrea!" " Forgive me." "You wanted a cup of tea?" "I'm going to take it from Masha." "Here's tea!" "Whose cup is that?" " Your aunt just wanted a cup of tea." "Here is tea." "I became very skillful." "You don't want some tea?" " No, thanks." " No?" "Take at least a canape." " I can't, my hands are busy." "Then leave everything and come help me in Sergio's place." "We must cut the cake into equal parts, and Sergio said you got an unerring eye." "Unerring!" "Strikes any target at more than 100 paces." "But what do I do?" "I'm dismissed so?" "You will keep company to my aunt, you've been with me too long." "Come, Andrea." "But sit down, Sergio." " Thanks." "Where are they going Masha and Andrea?" " Be good, dear." "The sun is going, I wouldn't want it to be a storm." " I hope not." "Do we go?" "Masha, who taught you, so young, so many coquetries?" "What did you say?" "It's hot, is it not?" "Look how the sky has overcast." "Lay the tray there, and now come here." "Show your skills at least on this cake." "So, you think that I'm a flirt?" "That I'm a flirt, me?" "Up to desperation." "Andrea!" "Why Masha laughs so much?" " Don't know." "Maybe I said something that's had the luck to make her laugh." " What?" "Here dear, that's the cake." "Share it among you children, and do not quarrel." "Sorry, I didn't do it on purpose." "It weighed too much for us kids!" "You hurt her, you've been cruel." "Even cruel!" "Before, a flirt, and then cruel." "But explain yourself, at least!" "A flirt with you, or with Sergio?" "With Sergio!" "I don't see why you would need to do it with me." " You don't see?" "That man you are!" "But why do you say so?" "Listen Masha..." "If between you and Sergio.." "something were to happen,.." "for the love I have for you since as a child, I'd be very happy." "Sergio?" "I had not even thought of!" "But I'm grateful for giving me the idea." "After all, even his appearance yesterday at the brook..." "Are the servings good this way?" "I don't see your unerring eye." "This is really too small." "Well, we'll give it to that boring Baroness." "Let's go get the plates, but with the cake, of course." "You coming?" "Why did you hand in your resignation?" "What resignation?" "But yes, Sergio..." "Oh, how nice, the sun is back!" "Sergio said that you resigned from the army." "Sergio is a fool and a rude, I'd never expect this from him." "Poor Sergio, yet he esteems you so much!" "He told me of a beautiful castle, a charming country life..." "But I'm less naive than him and I wonder why, or for whom, all this?" "Look, Masha..." " Who will you bring in there, Marina?" " Well, enough!" "A man cannot put up with this by a little girl!" "Don't you understand that for me you're a little girl, that you always were?" "A little girl like Antonietta, no more..." "I'm your friend, but I can't allow you to use me to make Sergio jealous!" "And if your flirtations are for me, they're wasted, like Antonietta's ones!" "You did well to tell me this." "You're right, I am a silly little girl." "Sorry Masha, I didn't want..." " You don't have to apologize." "Masha, come and help, is about to blow up a storm!" "It is I who must apologize to you." "Take cover if you don't want to get wet!" "Major, take cover." "I'm going to look for your horse, that was frightened." "Andrea, you're still here!" "Shelter me with your cloak!" "No, keep it, so I am small and I don't take much room." "Shall we go under the tree?" "How it rains!" "You were right, earlier." "Do you mind if you stay close to you?" "Look at Sergio, how funny!" "He's cute, though." "With that sheet on the head, looks like a ghost!" "Masha!" "Masha, Andrea, come, it doesn't rain here!" "Want to go to him?" "You won't tell anyone?" "No, indeed, I'll tell your aunt that I left you safe in the carpenters cabin." "How good of you to protect young people!" "Gentlemen, good evening!" " 'Evening." "Andrea, where you been?" "The ladies were worried about you." "I was by them to dry myself." "It was a real squall." "Masha was afraid." " Sorry." " At each thunder she plugged her ears." "And Antonietta!" "What a girl!" "During the storm she wanted to go look for you." "Wrong shot!" "What's wrong, you're in a bad mood?" "What was I saying?" "Oh, yes." "You know that Masha is a delightful creature?" "Don't laugh, but if I said that I start imagining pictures of family life,.." "with Masha of course, would you believe me?" "I really don't know if I love her, but my mother would be so glad!" " Excuse me." "I know that you were very indiscreet on a confidence that I wrongly did to you." "Indiscreet?" "Oh, you mean, your resignation?" "Come on, Andrea!" "You should have said that it was a secret even to Masha." "Oh God!" " Gentlemen!" " What happens?" " What was that?" "This is the third time you sit on the table where I'm playing." "You are a boor!" "And if you're not a coward as well,.." "I'll wait tomorrow at 6:00 at the cherry trees grove along the river!" "I pray you, gentlemen, to act as my witnesses!" "It is 6:00." "Andrea!" "Captain Ivanov, Captain Bolkov." "Gentlemen, I suppose we all agree on the conditions of the encounter" "Will you write down your principals' names?" "The usual conditions?" " For the choice of the guns?" " And the distance?" "The usual conditions." "12 steps away, one shot each." "Have you written the names for the choice of the guns?" " Here's my card." "Here's the card of my principal." "For the duel are chosen the guns of Prince Drutzky." "The first shot is given to Prince Drutzky." "So, the first shot is for me?" "Always too lucky!" "Would you please choose the gun, Count Anickoff?" "Andrea, it's not my fault." "I wished you'd shoot first." "Maybe it's better so." "You're so skillful you wouldn't let me the fun of firing." "Just to form." "Now that guns are ready and is about to order fire,.." "I ask if you want to reconcile." "I fulfill my duty." "For me, I agree." " Don't waste time, please." "Then go on, gentlemen." "Andrea..." "Are you very angry, Andrea?" "I see from here the wrinkle on the forehead." "If you must kill me, at least don't do it with so much hate." "Are you afraid?" "What are you doing, Drutzky?" "Is it loaded well?" "It'd be a shame if it were discharged." "Should I wait until you've finished eating?" "Shoot as well." "Cherry more, cherry less..." "Oh, I'd regret not to eat this one!" "It seems to me that you're not set to die, at this time." "My shot would deprive you of life,.." "and you don't care, I see!" "Nicola Bolkov!" "Don't want to shoot anymore?" "Take it!" "I don't want to shoot." "For now." "Basically you don't love anybody, nothing binds you to life." "What good would I have killing you now, if you don't care about dying?" "Whatever!" "Then your shot is reserved for the moment that you prefer." "For when you'll be happy!" "For the moment when you'll regret to die!" "For the moment when I'll regret to die." "Your choice." "You'll just have to show up and call:" ""Sergio"." "We'll count 12 steps, I'll place myself this way before you,.." "and you shoot." "Is allowed in the rules?" " Rules or not, I agree." "And that's all." "Bravo, Andrea!" "You cannot accept!" " But I accept." "Odd thing, such a duel was never seen." "Will all talk about it, in Petersburg." "I'll come and get my shot someday." "The day when you're really attached to life!" "And that day you'll beg me to spare you!" "And I'll wait for you!" "Here, I have kept this bullet." "While my hatred had wanted to delay, for more cruelty, the shot that I was due,.." "Sergio had spared my life." "Then, when you met again Sergio..." "I never met him again." "In fact, I felt for him an even greater hate." "His generous act prevented me any vengeance." "Like a madman, I left Russia and never saw Masha." "For two years I ran desperately through Europe to find relief to my anxiety." "Then,.." "little by little, made its way into my soul the futility of my hatred,.." "the futility of my empty and tormented life." "Monsieur de Valmont, thank you for what you have prevented this morning." "When we choose a destiny, we must have the courage to live it up all the way." "And this, is the story that you wanted to know." "But why do you live always so aloof?" "If you you tried, sorry, to cultivate less your sadness,.." "relationships with people may distract you,.." "and you may regain the sympathy of a friend." "I thank you." "The moon has arisen!" "Look how it shines, the top of the mountain!" "Will you come with me tomorrow?" "The climb is not difficult, we'll be back before nightfall." "Do you accept?" "You will soon get bored with a partner so unsociable like me." "I will give orders to wake us up at six." "Count, in the hall two ladies wish to see you." "Who, me?" "Actually, they asked for Major Anickoff." "Major Anickoff?" "I do not understand." "You must excuse me, but..." " So, see you tomorrow, agreed?" " See you tomorrow." "I wish to be woken up at 6:30 in the morning, me and Count Anickoff." "The Count as well?" " Yes." "We go for a hike." "Do tell Hans, the guide." "We will leave at 7:00." " Okay, at 7:00." "Anickoff!" "Oh, Anickoff!" "Do you recognize me?" "Really?" "Have I changed much?" "Hello, Hans." " Good morning, sir." "My partner will be here soon." "How's the morning for the outing?" "Not very good, at dawn the summit was covered in fog." "Count Anickoff came down?" " The Count has left last night." "How, he left!" "Did he let anything said?" "He left the baggage to be sent." "He left?" "Last night?" "And to where?" ""Send to Count Andrea Anickoff." "Post Hotel." "Kiev, Russia."" "One year later, in the Roman countryside..." "Monsieur de Valmont!" "This way!" "This way!" "By there, by there!" "The boar ran off that way!" "There is Diana there!" "It's nothing, we'll carry her to the nearby farmhouse." "Let's go." "Hey, are they here those with the Prince of Rignano?" " No one here yet, sir." "Bring some water." "Well, what do you think of our hunts, Monsieur de Valmont?" "Very interesting." "These places are full of charm." "Pour, boy." " The boar, however, escaped you." " Escaped?" "No!" "It surely stumbled into the group that was on stand on the other side." "Here they are!" "What did I tell you?" "Oh, nice shot!" " Not mine." "I shot once but I missed it." "It was below." "It was him who hit him." " Who?" "Anickoff?" "Don't know how he did, he shot from his horse." "A true masterstroke." "A shot of Anickoff can only be a masterstroke." "De Valmont, you here!" "It's a great pleasure to see you again." "But, you know each other?" " We met a year ago, I think." "Isn't it?" " Indeed." "Anickoff!" "De Valmont,.." "Rignano!" "On horseback, gentlemen, if we want to be in Rome on time!" "On horseback!" "On horseback, come on!" "Monsieur de Valmont!" "Dear de Valmont, I am really happy to have met you." "That time I disappeared so suddenly!" "You live in Rome now?" " Yes, from about six months." "A villa out of San Sebastiano gate." "Monsieur de Valmont,.." "I held you back to tell you that I will never know peace.." "until you tell me that you excuse me for my sudden,.." "indeed, I should say rude, departure." "You are already excused." "An event occurred that night, when we parted." "Remember?" "You were going up the stairs,.." "I instead walked to the lobby where, waiting for me, there were two ladies." "I recognized them immediately." "They were Antonietta and her mother." "Anickoff!" "Oh, Anickoff!" "Oh, how happy I am!" "Do you recognize me?" " Sure." " Really?" "Much time has passed!" "You find me much changed?" " Not at all, indeed!" "Good evening, Antonietta." " But, Antonietta!" "You wanted so much to come and you don't say anything now?" "She, yes, has changed a lot." "Remember how lively she was?" "Yes, a very lively little girl." " Yeah." "But now she's set to become a young lady." " But how beautiful here!" "Much nicer than our hotel!" "How beautiful!" " Won't you sit down?" "Excuse me, but I don't know if I may still call you Antonietta." "I came to talk to you." " Anickoff, Antonietta, what are you whispering?" "This girl has become strange!" "She was on holiday in Porterhaus." "The air is so good!" "We found out by chance that you're here, and she wanted to come and see you." "At this hour, said I?" "Antonietta always had a soft spot for you." "Oh, tea in a samovar!" "But what a surprise!" "What a nice surprise!" "And besides, so far from our Russia!" "We are just leaves whipped by the wind, isn't it true, Anickoff?" "You have traveled a lot, right?" " Yes, a lot." "Too much." "Antonietta is so ill." " Give me." "I'll serve the tea." "But of course, yes, dear, thank you!" "So you make yourself useful for something." "Oh, but how good you are!" "You were quite right, Anickoff,.." "she's grown up now, almost a young lady." "Oh God!" "You've spilled the tea on me!" " Sorry, I didn't do it on purpose." "How was reduced the new dress!" "If Aunt Anastasia knew it!" "Mom, the maid can remove the stains." "Right, Anickoff?" "But yes, certainly." "Come, ma'am, please." "You say that it can be cleaned?" " Certainly, certainly." "Here, madam." " A small tragedy happened to me!" "What does all this mean?" "You wanted us to remain alone, and it seems you succeeded." "You have to talk to me?" "Come on, then, what is this big secret?" "Antoinetta, what happens to you?" "It's useless, you will never forgive me." "You must have been so unhappy, in these two years!" "I don't understand." "I'm so ashamed." "I don't know how to begin!" "If you knew..." "Masha..." "Perhaps your mother needs you." "And it's better that I go with you." " Oh, Anickoff!" "I was such a child then!" "And you treated me with such indifference!" "But later..." "later I felt so bad!" "Mom thought I was sick, and instead, only I knew what I had." "It was this... that I had destroyed your happiness." "In short, what are you talking about?" "And if you want to talk, do it." "Your mother can arrive at any moment." "Masha had charged me to deliver it to you,.." "the night of the outing, two years ago." "Masha loved you, and I..." "I think I too was a little bit in love with you." "I was so jealous of Masha!" "I don't care about Sergio, I assure you." "I just tried to make you jealous." "Why don't you speak?" "Must it be me to say I love you?" "Answer me, please." "But before leaving I saw her, and I understood she still loves you." "She lives enclosed with her mother in Kiev, and sees no one." "She's so unhappy!" "She's always loved you, she's waiting for you!" "Quick!" "Whip!" "Hey, folks!" "But there's no one here?" "How everything has changed!" "Grandpa!" "Not a chance..." "Hey kid, this is not where you change horses?" "Dad, dad, there is a man in a hurry." "Coming." "Meanwhile, you want a drink?" "Dora!" "Dora!" " Huh?" "There is a gentleman, give him drink, while I change the horses." " Well." "Dora, don't you recognize me?" "I was here 2 years ago for maneuvers!" "Yes, I think." "But if you want to drink, come inside." "Hey, Peter!" "Here, by here." "Please, come forward." "Peter, make the horse change, and then let me know!" "If you wish to sit a moment." "I'll pull up the mats and let in a little light." "So what do you drink?" " Whatever." "Come on Vassilj, be good, help me, hold the tray." "What a beautiful view, right?" "That is Kiev." "Wasn't there a vine once, there?" " Yes, it's true." "But with frost has dried." "It's been a year, last year!" "The snow that came down!" "It was so high, you could not walk out the door." "There is vodka, but if you have time, I prepare some tea." " No." "Then I will give you this vodka." "It's special!" "But you're Major Anickoff, the one who always played billiard!" "Who knows where my mind was!" "Come, excellency, don't stay here in the dark." "Here, come and sit here." "I'm really glad to see again a gentleman like you." "Here." " Mom, mom..." "Petrouschka, don't scream, don't you see how good is Vassilj ?" "Tommaso, come Tommaso, come and see who's here!" "Mom, look! "Boom boom"!" "Oh God, what do you do?" "Leave it alone!" " Don't be afraid, does not work." "Are you sure?" " Yes, it's broken and discharged." "Please, remove it from his hand." " Give me, dear." " Thanks, Excellency." "What do you drink?" "Is it good?" " It's good, but it's not for you." "Petrouschka, don't bother the gentleman!" "In punishment!" "Dora, you called me?" " You remember him, Excellency?" "It's Tommaso, the waiter." "I married him!" "Where's your mind?" "Don't you recognize His Excellency?" "Of course!" " Come on, say hello!" "So, you've come to wait for your friend." " Poor Petrouschka, come here." "Your friend will be here soon." "He said: "I'll be back the 7", and today is 7." "Who are you talking about?" " But, of your friend, Prince Drutzky!" "Drutzky?" "Will pass by here?" "Yes!" "A month ago he was here, went to Kiev for the service, and said:" ""Today is 7, next month on the 7 I'll pass again."" "Exactly!" "He said the 7, today is 7!" "Your Excellency, the horses are ready." " Wait a minute." " Should I wait?" "A gentleman as cheerful as the prince, I've never seen." "They were always together!" " I've never seen two friends like them!" "What a fright we had, that night when you quarreled!" "There, right there at the billiard." "How troubled you were that night!" "The prince, instead, not at all." "When you went out, he said:" ""He'll get over it, you'll see!"" ""How can anything happen with a friendship like ours?"" "He spent the whole evening saying that basically you have a heart of gold." "As for that, excuse me, I think he was right." "But are you quite sure he will pass by here, my friend?" "Sure!" "Should already be here." "You'll see, he won't be long." "So, the horses?" " Unhitch them, Peter." "We'll wait for prince Drutzky." "Come on, quick, come down to help Peter for the horses." "What are you looking at?" " I look at that village there." "That big village is called Kiev." "I've been there with mom." "Oh yeah?" " Why do you always look at it?" "Because when I get there I'll be happy." " So, why don't you go?" "Because to be totally happy..." "Beautiful!" "What is it?" "It's gold?" "Will you give it to me?" "I can't, I must give it to the gentleman who will pass by here." "And I must apologize, because that gentleman is my friend!" "I am Lieutenant, and I'll stay such for my career!" "This will be really my glory!" "In a few years, I will simply be called "The Lieutenant", by definition." "We are at the crossroads, turn left." " Don't we pass by the inn?" "No, the captain is in a hurry." " Sorry to force you to take another route." "Oh, for a few more minutes we can get into town on the side of your barracks." "Your Excellency?" "What shall I prepare for dinner?" " Nothing." "You'll see that the prince will be here soon." "Look where that brat fell asleep!" "No, leave him alone, poor Petrouschka." " Then I put the lumen here." "Good evening, Excellency." " Good evening, Demetrio." "Gioacchino, remain available to the captain." "Farewell, Alessio." "See you tomorrow!" "Has then got married Adrian, the cook?" "Yes, but it's the lackey, not the cook." "He quarrels with his wife already?" "Good evening, Excellency." " Good evening." "I'm back." "The Countess is at home?" " She's upstairs, I'll call her." " Thanks." "Good evening, Sir." " Good evening." "Where are you going with that lamp?" "Maria Nicolajevna!" " Good evening!" " I'm back, I had a new furlough." "This is for the large room." "You know you have a wonderful complexion?" "Your Excellency must be joking." "This is for the little boudoir." "Which is the lumen for the library?" " This." " Miss Masha is there?" "Yes." "Today she gives lessons to the poor children of the neighborhood." "Alright, thanks." "Good evening, Countess." "I found an occupation, I take it to Masha." "You mind?" "Sergio, thank you so much for coming." " You think that also Masha will be glad?" "Oh, Masha is glad." "She says nothing, but in her heart, is happy." "Miss, miss ..." "I sure have drawn the flower well!" "When you have drawn the flower, we will make the little house." "Where shall I put the lumen, excellency?" " On the table, of course." "Masha!" "Sergio, it's you!" "But you made a mistake, that seat is for the top of the class." "You consider me so little, then?" "Look at that masterpiece!" "Come on, kids, it's late, go home." "Mom, would you mind distributing the packages yourself, this evening?" "Can I help you?" " Oh, no, tonight you will help Mom." "I..." "I...will be right back." "Masha, my soul, what are you doing?" "This ..." "No!" "And this ... neither!" "This makes me look older." "And this?" "Maybe this one." "Look at me, Maria, look at me." "No, stay there, stay there!" "Look!" "You like it?" " Yes, is so beautiful!" "No, I don't like anymore." " Why?" " I do not know what to wear." "It's 2 years I don't get a new dress." "Oh, Maria, what should I do?" "But there's a lot here!" "Maybe the black one!" "What do you think?" "All in black, with a rose in the hair." " Yes, black!" " No." "The white one, yes, white, the gayest of all." "It's the most beautiful." " Sure." "Maria hurry, come here!" "One minute dear, I come!" "There is such a mess ..." "Forget everything and come here!" " Wait!" "Maria, tell Anastasia to prepare for lunch." " She knows already, dear." "As soon as he arrives, everyone in the house knows it." "They all love him, he's so cute!" "Cute?" "You're all in love with him." "Oh, Maria, you should be ashamed!" "Then I shouldn't be the only one ashamed." " What you say!" "Ugly gossipy!" "I don't care anything about him!" "He is completely indifferent to me." "Yes." "Indifferent." "Indifferent..." "Or maybe..." "Who knows!" "Masha!" "You disappeared so suddenly." " Am I not a little more beautiful, so?" "Lovely, dear." "But what have you done?" " Let, Maria will take care of it." "She made such a mess." " It's true, Mary?" " Yes, dear, my soul!" "You don't know what a pleasure it is to see you finally glad." "It seems to me as if at last had entered some air in this house." "Mom, the first time Sergio came, two months ago,.." "I hadn't seen him for two years, from the time of Andrea." "As soon as he saw me, he told me:" ""You must marry me." Just so, imagine!" "I..." "I didn't know what to answer." "It seemed impossible, I lived so alone, after Andrea." "Then he said:" ""I'll be back in a month."" "And last month he returned, and asked again: "Do you want to?"" "I ..." "Oh Mom, that foolish I was!" "I told him no." "How I have regretted it, after!" "Then he said: "In a month I'll be back for the third time."" "And I feared that he wouldn't come back!" "Oh, Mom!" "And now that he's back again,.." "what if he's weary and doesn't tell me anything?" "Then, be aware that Sergio has asked me if I had any objection to your marriage." "Oh, Masha!" "Masha, what splendor!" " You like?" "You like?" "So, you want me to wear it to the party?" "For the engagement we'll need a wonderful party ..." "A marvelous party." "Come." "Come with me." "Oh, how long has not been opened this old salon!" "Soon, Sergio, a party with lots of guests, lots of music, lots of light!" "Help me to open!" "Open, open!" "Would you like tomorrow?" " Oh, tomorrow may be too soon." "But I have only a few days furlough!" "Tomorrow then." "Better, now!" "Oh, to dance, dance, dance!" "Masha!" "Masha, what's the matter?" "Oh, Sergio, I was so unhappy, these two years, but now enough, enough." "You must help me to be happy." "I feel that I will be happy with you." "We will go and live in Moscow!" "We must be happy, so happy!" "I went into town in late afternoon,.." "and after so much travel my happiness was nothing anxious." "Masha loved me." "I felt among my people." "I wandered the streets in search of the house of Masha, and I felt lighter." "As if for the first time in my life I had thrown off a burden." "Hey, buddy, wake up!" " Coach, your excellency?" " No." "Have you ever heard of the palace..." " Uh, wait a moment..." "Andrea!" "Don't you recognize me?" "Alessio!" " Yes!" " But, sure!" "You haven't changed at all, except for the shiny new ranks." "But, if you're here, where is Sergio?" " What, you don't know?" "Come along." "Where?" " Here, with me!" "Come!" " Where?" "Where else?" "To Sergio's!" " But, there's a party here!" "I..." " I should think so!" "But this is Sergio's house?" " No, it isn't." "Here Andrea." "The gentleman is with me." "Come, come." "Wait here, I'm going to look for Sergio." "Oops, sorry." "Sergio!" " Drutzky dearest, a thousand good wishes, to you and your fiancee." "Thanks Admiral, thanks for coming." "Good evening." "Sergio!" "Sergio!" "You!" "You here!" " Yesterday I waited so long at the inn." "You know, we parted in a rather strange circumstance." "I assure you that I am very pleased to see you happy." "But that day, you forgot something." "But you have not forgotten." " I ?" "Come!" "Great night, Prince!" " Yes, of course." " Sergio, what's up?" " Not here." "Come." "You have not forgotten." " What?" " And you're not changed either." "I recognize your cool obstinacy, your diabolical pride!" "You waited two years that I'd be happy." " Sergio!" " You're back this very night!" "Nothing to say, you chose the right time." "Well..." " Sergio, you're wrong!" " I accepted your proposal!" "This time it's your turn, as agreed." "I said it myself!" "We'll count 12 steps, I'll stay so, before you, and you will shoot." "But I,.." "I won't beg you to spare me!" "You may well use this, if you trust." "I also recognize you, you're always the same swagger." "You won't think that I'm afraid, I hope." " You really sure of not being afraid?" "And you would upset so this party?" "They're playing the polka." "It's very noisy, take advantage." " Sure." "No." "In this case, I prefer mine." "Only, too bad that is not loaded with cherry pits." "Sergio!" "Sergio!" "Leave us, Masha." "This man has made my life unhappy." "I don't want him to take you too!" "Go away!" "Go away!" "I hate you!" "Sergio, I'll wait at the same place as last time." "At dawn, if you're not a coward." "Excuse me." "I'm so glad, my dear, for you and for Masha." "Masha has suffered so much, but fortunately it is over." "There they are." "You allow?" "Sergio, I'm afraid for you." "Why don't you speak?" "Here, amongst the people?" "Why did he say "at the same place as last time" ?" "What's between you?" "Speak!" "Speak!" " Be careful, they look at us." "Where is he waiting Andrea?" "I'm afraid." "I do not want this horrible duel." "Do you understand?" "Ornoloff !" "Good evening." "Sorry, I hadn't seen you yet." "Masha, isn't this the waltz you promised to my friend?" " Yes." " I'd be happy." "You are thoughtful." "Maybe the music?" "Sure, at the bottom of all happiness, there is always a little melancholy." "Excuse me, I'm a bit tired." "Would you accompany me to sit?" "Do you mind going to tell Sergio,..." "it's a game between us,.." "that if he does not want to speak, the other person will speak." "Immediately." "Gone out with the impossible hope to find me,.." "Masha sought me all night, to beg me to save Sergio." "Poor creature!" "The absurdity of the undertaking began to appear her.." "after she had visited all the hotels in the city." "As time passed, her hope was fading." "In despair, she wandered even in the humblest districts, seeking at random." "She wanted to find me at any cost before dawn, hour of the duel." "But dawn was near now." "The reveille sounded in the barracks." "The day had now come, and with it, the time of the duel." "Maybe it was too late already." "Masha kept on running, walking aimlessly,.." "not knowing what she was doing, like a madwoman." "On, Nicoletta, if we want to go to mass." " It's very late?" "Oh!" "What are you doing here?" "What is the matter?" "Come on!" "Sure it's late." "Have you seen that woman?" " It's late, I said, it's 7:00am!" "Luckily the church is not far away, but it's already day since long!" "Andrea!" "Andrea...you didn't go?" "No." "Why?" "Farewell, Masha." " Andrea!" "One moment ..." "Thank you." "You were generous." "I wandered all night hoping to meet you,.." "and beg you to spare Sergio." "And you hadn't gone." "You love him much?" " Yet one moment." "Soon we'll be home, and we'll have to part." "I wanted to tell you,.." "when I lost all hope to meet you, I entered the church." "And I prayed, I prayed ..." "and you were there!" "Why didn't you go?" "Because of me, right?" "Because you love me a little." "Oh, I too loved you, so much!" "I can tell you, now that it's all over, and that I must marry Sergio." "Farewell, Masha." "Yes, it's better." "Farewell." "Oh, Andrea!" "Why didn't you come back sooner?" "Masha ..." " Why didn't you come back on time?" "Why?" "Antonietta, your cousin, for a jealousy of bad girl,.." "only last week delivered your note." "My note?" "Which one?" "That note you wrote me on the evening of the outing." "Didn't you ever receive it?" " No, never." "Oh God!" "Only last week she gave it to me." "Then, like a madman, I traveled 600 miles day and night,.." "killing the horses to arrive to you on time." "But when I arrived ..." "Oh!" "One day sufficed." "If only you had come one day sooner!" "If only you had come yesterday!" "Only yesterday I gave my word to Sergio." "Masha, but if you really love me, what does the word matter?" " No, Andrea." "I gave my word, and I must keep it." "We must part now." "You will leave?" " Yes, this very day." "Farewell." "Farewell, Masha." "Farewell." "Masha!" "Masha!" "Masha!" "There, on the bed." "I'll do some light." "Andrea..." "Andrea!" "From that day, it's now been almost a year." "Here." "This is my house in Rome." "Good evening, Your Excellency." " Good evening, Count." "Good evening." "Finally, I'll tell you that Sergio freed Masha from her promise." "Please come in." "I hope you'll be my guest these days." "Thank you." "And Masha, then?" "You hear?"

Relationship of serum Wnt1-inducible signaling pathway protein 1 levels with coronary artery disease and its severity. To investigate the association of Wnt1-inducible signaling pathway protein 1 (WISP1) concentrations in circulation with the presence and severity of coronary artery disease (CAD). A total of 120 consecutive participants who underwent coronary angiography between May 2017 and July 2018 at our center were enrolled. Participants were divided into two groups based on the presence of CAD. Serum WISP1 levels were measured using enzyme-linked immunosorbent assay. Univariate and multivariate analyses were used to determine the association between variables and the presence of CAD. The average age of the study population was 59.8 years, 66.7% were male, and 58.3% were positive for CAD. Serum WISP1 levels were significantly higher in patients with CAD than non-CAD group (339.8 vs. 322.4 pg/ml, P = 0.012). Moreover, a stepwise increase in serum WISP1 levels was observed with the number of diseased vessels (zero-vessel, one-vessel, two-vessel, and three-vessel disease: 322.4, 324.7, 345.4, and 392.1 pg/ml, respectively, P < 0.001) or Gensini score (r = 0.376, P < 0.001). Importantly, serum WISP1 levels were positively associated with the presence of CAD ( β = 1.011, 95% confidence interval: 1.001-1.021, P = 0.026). This association persisted after adjusting for age, sex, hypertension, type 2 diabetes mellitus, hypercholesterolemia, smoking, and high-sensitivity C-reactive protein ( β = 1.011, 95% confidence interval: 1.000-1.021, P = 0.047). In addition, serum WISP1 concentrations were positively correlated with BMI (r = 0.212, P = 0.020), insulin (r = 0.237, P = 0.009), and homeostatic model assessment for insulin resistance (r = 0.223, P = 0.014). We demonstrated for the first time that serum WISP1 concentration is associated with the presence and severity of CAD.

"I met this wife of mine and things got onto a better track" turning points in risk development. In this study, qualitative and quantitative approaches were combined to study the mechanisms involved in turning-point experiences among individuals who had been exposed to several risk factors in childhood and adolescence. The study was part of the Jyväskylä Longitudinal Study of Personality and Social Development, in which the lives of the participants (196 boys and 173 girls) have been followed from age 8 to age 36. The data concerning turning points was collected by semi-structured interview when the participants were 36 years old. Participants were classified into six developmental trajectories according to risk factors at ages 8-14 and problems of social functioning at age 36. The results showed that individuals with an unsuccessful childhood constructed their life courses less often in terms of education, work and social transitions compared to others. Those who were managing well in their lives at age 36, despite several risk factors in childhood (resilients) reported positive experiences and plenty of choice in relation to their turning points. Participants in the vulnerable subgroup, for their part, perceived turning points more negatively, and reported few opportunities for personal choice. Altogether, the results indicate that childhood experiences influence the content of turning points in adult life by shaping the direction of actual life paths. The quality of current life, however, has a greater bearing on the way turning points are evaluated.

It is a common problem for drivers to find and read the addresses of residences and businesses while driving, especially at night. One known solution to this problem is to internally illuminate the address from within a hollow sign housing, usually having a flat rectangular shape for mounting to the wall of a house or hanging from a lamppost. Another known solution is to place the address sign closer to the road, rather than mounting it directly on the building. In some cases, signs which have been separated from the building and moved closer to the road, for example attached to a mailbox or mounted in the yard at the edge of the street, have also been internally illuminated to further aid recognition at night. An example of an internally illuminated address sign located on a house is shown in U.S. Pat. No. 2,798,323 to Witz. It has a hollow housing with an internal lamp and a partially translucent or transparent front face. U.S. Pat. No. 4,843,525 to Williams discloses an internally illuminated address sign mounted in a yard with a number of ground piercing stakes. The sign is additionally solar powered. Another solar powered illuminated yard marker is disclosed in U.S. Design Patent No. 315,928 to Flieder. A conventionally powered illuminated yard sign is disclosed in U.S. Design Patent No. 307,768 to Levin, again having a relatively one-dimensional hollow housing with a yard mounting stake. U.S. Design Patent No. 250,913 to Kozial discloses an internally lit address sign attached to a lamppost. U.S. Pat. No. 5,143,285 to Wise discloses a hollow mailbox post with transparent windows on two sides for address information and an elongated bulb in the post for internal illumination of the address. These prior patents do not fully address the need for an internally illuminated address sign which can be easily read by drivers approaching from either side of the street, is weather-resistant, is simple to make, and is an attractive structural addition to a yard.

Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells. Aconitum alkaloids mainly contain highly toxic aconitine (AC), mesaconitine (MA), and hypaconitine (HA) and less toxic benzoylaconine (BAC), benzoylmesaconine (BMA), benzoylhypaconine (BHA), aconine, mesaconine, and hypaconine. The efflux transporters including P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 2 (MRP2) can efflux toxicants to prevent poisoning. Our previous publication has proved that P-gp and BCRP contributed to the efflux of AC, MA and HA, which is demonstrated in the human colonic adenocarcinoma cell lines (Caco-2 cells), Mardin-Darby canine kidney cell lines transfected with MDR1 or BCRP (MDR1-MDCKII and BCRP-MDCKII cells). However, the role of MRP2 remains uncertain. The MRP2-MDCKII cells were used to determine the efflux ratios (Er) and intracellular amounts of Aconitum alkaloids. In addition, the importance of MRP2 was further investigated with or without the MRP2 inhibitor, LTC4. The Er values of AC, MA, HA, BAC, BMA and BHA in MRP2-MDCKII cells (6.4 ± 0.3, 5.9 ± 0.5, 2.2 ± 0.2, 1.6 ± 0.3, 1.7 ± 0.2 and 1.9 ± 0.2 respectively) were significantly higher than those in MDCKII cells, which were close to 1. In the presence of LTC4, the Er values of AC, MA, HA, BAC, BMA and BHA were reduced to approximately 1 and their intracellular amounts were also significantly increased in MRP2-MDCKII cells. MRP2 was involved in the efflux of AC, MA, HA, BAC, BMA and BHA, which would be useful for the safe application of these components or their herbs.

A natural history study of adolescents and young adults with sickle cell disease as they transfer to adult care: a need for case management services. Life expectancy for adolescents with SCD now extends well into adulthood. As a result, adolescents transfer to adult care. Little empirical evidence exists to show how transfer occurs and how well the current practices now work. The aim of this study was to obtain a database on the experience of adolescents/young adults with SCD that transfer to adult care. We assessed their treatment compliance, independence, and whether they receive uninterrupted care. Data were obtained through patient and provider interviews and patient record reviews. Results indicate patients leave pediatric care without adequate transfer preparation and readiness to transfer is not the major consideration in the decision to transfer, follow-up often ceases once the patients leave pediatric care, and patients who maintain follow-up appointments are more efficient in managing their illness (self-efficacy). The model for a structured transitioning process is provided with recommendations for nurse case managers to maintain follow-up.

Colorectal cancer is the third most frequent type of cancer in the world having an occurrence of about 1 million new cases every year. The incidents of cancer are considerably more frequent in the industrial part of the world. Current techniques for mechanically performing anastomosis of hollow organs use circular mechanical staplers, which execute the connection of the tissue edges of the dissected hollow organ by metallic or plastic staples. A wide variety of surgical staplers have been developed for gastric, oesophageal and intestinal surgery. In performing surgical anastomotic stapling, generally two pieces of the hollow organ are joined by a ring of staples with a closed loopstapler. End to end anastomoses are generally performed by intraluminal surgical staplers that deliver a pair of staggered rings of staples. During this process, a circular knife blade is used to separate the tissue that is held within the circular ring. The separated tissue is then removed with the stapler to form a circular opening within the lumen along the stapling line. A major issue regarding anastomosis healing is the blood circulation of the anastomosis during the healing process. Despite substantial development of surgical techniques during the last decades, morbidity and mortality after resections in the gastrointestinal tract, e.g. due to anastomotic leakage, remain as serious problems. Ischemia and inflammation, which are natural parts of the healing process, may cause leakage and secondary infection that may be fatal for the patient in the stapling area. Therefore, it has become common practice to relieve the pressure from the anastomosis by performing a deviating stoma, especially when the anastomosis is carried out in the lower part of colon and in rectum. By relieving pressure and faecal stream from the anastomosis during the healing process, the leakage incident may be reduced and fatal consequences of anastomotic dehiscence can be avoided. The inconvenience for the patient is obvious, since the patient must have a temporary stoma for a time period of about 3-6 months, and then has to undergo a second surgery in order to close the stoma. Unfortunately in many cases, the closure of the stoma cannot be reversed and the patient is forced to live with a permanent stoma leading to lower quality of life associated with increased costs. Another problem arising from stapling of anastomoses is anastomotic stenosis. The critical area for healing is the contact area between the two ends of the hollow structure to be connected. The connection has to be liquid proof, and the cross section of the lumen should be as wide and flexible as the original lumen. The size of the stapler determines the size of the lumen and thus the contact area between the ends. Surgical staplers create a smaller and more rigid opening compared to the cross section of the original lumen due to the staples inside the hollow structure connecting the two ends thereof, i.e. a collar may be formed that may lead to stenosis. For solving this problem repeated need for dilatation is required. Another disadvantage associated with mechanical staplers, is that there is no fast, simple and reliable method to control anastomotic insufficiency, which at late discovery can result in abdominal sepsis. Furthermore, staplers require an incision in the intestine in order to insert the instrument into the bowel lumen. This additional incision increases the duration of the operation and the risks associated with surgery, e.g. secondary infections and anastomotic leakage. The stapler itself is a critical link, since there are several severe problems connected with the use of mechanical staplers in surgical anastomotic stapling, such as anastomotic leakage and anastomotic stenosis. Other disadvantages are high consumption of time and expensive instruments for the performance. U.S. Pat. No. 5,697,943 discloses a surgical instrument for carrying and attaching separate components of an anastomosis device to the end of tissue of a tubular hollow organ. The instrument includes an elongated housing having a proximal end and a distal end, first and second compression anastomosis device components, a supporting member operatively associated with the distal end of the housing, and an assembling structure associated with the supporting member and operable from the proximal end of the housing for assembling the first and second compression anastomosis device components within tubular body tissue.

Since the advent of the wheel, man has applied that structure in an incalculable variety of manner and use. One such use was the development of the inflatable tire, which tire could be used with great success in association with the automobile, trucks, tractors and great earth-moving equipment. Such tires range in size from the smallest to those weighing over four hundred pounds. Since such tires currently exist as interchangeable commodities, and since the tires may not be expected to last indefinitely, a problem arises concerning the movement of the tires from one place to another, in their own right. At times, this problem is preceded by the concern of even getting the tire off the ground. This problem becomes particularly acute with respect to farmers and the like who may own hoisting equipment but cannot afford a large capital outlay in order to possess a device whose sole use is to lift large tractor tires. It has also been observed that when a tire from a tractor or earth moving equipment needs replacement or repair in the field, many tire repair companies lack a device which readily engages a tire and in combination with a crane readily moves it and positions it.

The present invention relates to a device for coupling multiple connectors, of the type that comprises two connector supporting plates, particularly for pressure die-casting dies. Devices for coupling the supporting plates of multiple connectors are already commercially available. The plates, one fixed and one movable, are connected to threaded members, and the threaded member that is connected to the movable plate is formed by a rod which is provided with a threaded section and is supported for rotation by a movable ring integrated in the corresponding plate. The movable ring is supported by a fixed frame by means of sliding guides that ensure the assembly thereof with a framework which forms the support for a motor which is designed to turn the rod. The rotation rod is connected to the output shaft of the motor by means is of an intermediate shaft provided with a threaded section which cooperates with an internal thread of the frame in order to provide the longitudinal movement of the rod before the threaded section thereof cooperates with the other threaded member. The rotation rod is connected in an angular manner to the intermediate shaft by means of a sliding joint which allows the rod to interrupt its advancement while it continues to be rotationally actuated. Elastic elements cooperate with the guides, allowing to block the advancement of the movable ring, but not the rotation of the rod if the two threaded members do not couple as soon as they make contact. In any case, this kind of device is not free from drawbacks. The coupling between the threaded members in fact occurs in a rough manner, except in unusual cases, since the shoulders of the threads make contact first and collide with each other; at this point the geometry of the device allows to stop the translatory motion of the plates until the two threads mate. Accordingly, the movements of the plates are not gradual and the geometry is particularly complicated. The aim of the present invention is to provide a device for coupling multiple connectors which solves the problems of conventional devices. Within the scope of this aim, a consequent object of the present invention is to provide a device which allows the coupling of connectors gradually and not discontinuously. Another object of the present invention is to provide a device which does not have a complicated geometry. Another object of the present invention is to provide a device which allows to perform the approach and centering movement with limited force. This aim and these and other objects which will become better apparent hereinafter are achieved by a device for coupling multiple connectors, comprising two connector supporting plates, one fixed and one movable, two threaded members which are supported by the two plates, one of said members having a combined rotary and translatory motion for the coupling and uncoupling of said plates, characterized in that the member provided with combined rotary and translatory motion is associated with a fluidactuated actuator for the approach and spacing of said threaded members.

"Hey, guys." "Where are Marshall and Lily?" "Something terrible happened." "Are they okay?" "Are they in the hospital?" "No." "Somewhere much... much worse." "Long Island!" "Tonight, we're moving out there for good." "Yeah." "Here are your spare keys to our new house." "Long Island?" "I don't understand." "You can get spray tans here." "ROBIN:" "I never let myself believe this day would really come." "It's like when they canceled" "Party of Five for the second time." "I mean when they..." "canceled sports." "Guys, we'll still see each other all the time, and we'll talk on the phone." "And I know people say that having kids means you won't see your friends anymore, but..." "Oh, God, this is good-bye, isn't it?" "No." "Stop it." "Guys, this doesn't change anything." "We are only a 46-minute train ride away." "Just pop out whenever you want." "So..." "I guess this seat is open." "(whimpering)" "I'll go get a chair." "So that's it." "No more Marshall." "No more Lily." "They're gone." "Which means... no lame married couple shooting down all my amazing ideas." "Guys, great news." "I'm the new leader of the gang!" "♪ How I Met Your Mother 7x14 ♪ 46 Minutes Original Air Date on January 16, 2012" "== sync, corrected by elderman ==" "NARRATOR:" "Marshall and Lily were almost done decorating their new home." "I like it there much better." "Yeah." "There was only one problem." "MICKEY:" "Wrong!" "This can't go here." "Kids, when he found out she was pregnant," "Lily's estranged father unexpectedly showed up on her doorstep." "It was a gesture she appreciated." "But after two weeks, they'd had just about enough." "That has to go there to cover up the splintery floorboard." "And you can't hang this picture here." "This isn't plaster;" "it's dried toothpaste." "Guys, you're so lucky I'm here." "I grew up in this house." "I know it like the back of my hand." "And this lamp absolutely cannot be here." "Why not?" "Blocks my view of the Widow Rodriguez doing her Jane Fonda workouts." "Isn't she a little old, Dad?" "Oh, you didn't see her when I was a kid." "In my mind, she'll always be 54." "I know he means well, but I can't take it anymore." "He won't leave, and-and he's acting like this is his house." "No, I know." "And these annoying notes he keeps leaving around?" ""I need absolute silence when practicing the drums."" ""Do not touch the fudge in my nightstand."" ""We need ant traps for my nightstand."" "I find myself hiding out here just because it's the only room in the house where he can't boss us around." "MICKEY (over intercom):" "Great news." "I put new batteries in the old intercom system." "Now we can communicate at all times." "Mickey out." "Look at what's become of our booth." "Looks like my old shop teacher's hand-- just sort of missing something." "Enough!" "I am sick of you two wallowing in sadness, instead of doing the healthy thing and pretending anyone who leaves you never existed in the first place." "I hate to agree with Barney's near-paralyzing abandonment issues, but he has a point." "You can't just stop living because two of your friends moved away." "Precisely." "Now, as new group leader, I say we go out and do something that we never would have done with Marshall and Lily here." "Ooh." "Remember that amazing idea I had that one time?" "Let's go to a strip club." "Nope." "So what do you say?" "Let's declare our independence with an on-da-peen dance." "On-the-peen dance." "No, we got it." "We got it." "Let's go to a strip club!" "TED:" "Well..." "I'm going to miss them anywhere." "Might as well see some cans while I'm at it." "I'll take it!" "Robin, Kevin, you in?" "NARRATOR:" "Kids, early in any relationship, there's a phase where you don't say no to anything." "Because you want to seem interesting... adventurous... and open-minded." "I call it Early Relationship Chicken." "Well, I'm open to anything." "Oh, mos' def." "So..." "So..." "I don't want to go to a strip club." "I don't want to go to a strip club." "But I don't want him to think I'm some prude." "Man, we've been saying "so" for a while." "Yeah!" "Yeah!" "(both grunt)" "Yes!" "Tonight is going to be legen" "(imitating Lily):" "Wait, are we sure it's a good idea to go to a strip club?" "Shut up, Lily!" "I'm in charge now-- dary!" "I've got no cell reception." "I wanted to call Ted." "This feels weird." "The last time I lived this far from him was my semester abroad." "You never did a semester abroad." "That's what I called it when we lived on opposite sides of campus." "Wrong!" "Please tell me you're not plugging that in there." "Yes, Mickey, that's exactly what I'm doing." "All right, fine." "I won't say anything." "It's... just that this was my room when I growing up, so I know it a little better than you." "Lot of great memories here." "Mostly just discovering my body." "That's it." "Mickey, since you got here, you've been nothing but judgmental and pushy and strangely obsessed with your adolescent sex life." "Tomorrow morning, you're out of here." "Well, I-I've just been trying to help you..." "We don't need your help!" "I..." "(door closes)" "Oh, it-it's okay, baby." "It had to be done." "(sighs)" "(electrical buzzing)" "(beep)" "MICKEY (over intercom):" "Too bad the one person who could stop you from making mistakes like that was told he has to move out next month." "Tomorrow!" "Tomorrow!" "Would either of you like a dance?" "(stammering)" "I'm always ready to rock." "(chuckles) And I'm always ready to roll." "So..." "So..." "I'm not ready to rock." "Rolling makes me dizzy." "Hell, yeah!" "Yeah!" "I'm buying my man a lap dance, 'cause that's just how I do!" "Party like a rock star!" "(trailing off):" "Party like a rock star..." "TED:" "Uh, hey, guys." "It's Ted." "Um... you're probably busy with the move still." "Um..." "Give me a call if you want to gab." "Sorry about using the word "gab."" "Ted, stop pining over Marshall and Lily." "Have some self-respect." "Now, put this fiver in your mouth so... that stripper with the lazy eye can vacuum it up with..." "Barney!" "Wh-what?" "I'm allowed to miss them, okay?" "They're my two best friends." "I'm your two best friends!" "And we're here tonight to show you there's no need to miss something when you can replace it with something better." "ANNOUNCER:" "Gentlemen, say hello to J-J-J-Jasmine!" "(Barney guffawing)" "Remember her?" "NARRATOR:" "So, a while back, we discovered the most amazing thing:" "Lily had a doppelganger who was a Russian stripper." "Look at her, Ted." "She's just like old, less-good Lily, but instead of bossing us around, she shows us her boobs." "No touching." "Okay, a little bossing us around." "I call her Better Lily." "Hey, Better Lily, please dance for my friend." "Barney, I don't need a lap dance." "I need to talk to my friends." "Who says you can't do both?" "Talk to her." "She's got ears." "Yes, she does have ears." "You want to touch my girlfriend's boobs?" "50 bucks." "Wait" " Better Lily is dating this behemoth?" "Sound like anyone you know?" "That's New Marshall." "This is our gang now." "Hey, guys, Ted again." "Starting to think you forgot about me." "Or replaced me with some cool neighbor." "What's his name?" "!" "(chuckling):" "I'm totally kidding." "Anyway, uh... just trying to remember what your faces look like." "Ted, when they serve alcohol at a strip club, you're not allowed to show your vagina." "100 bucks, and you will see the world, my friend." "They're already ignoring my calls?" "Look, I'm realistic." "I knew I'd have to get used to going to the dentist alone, but I didn't think they'd cut me out completely." "If they don't need us, we don't need them." "Yes!" "Finally!" "By the way, did you see how she opened that bottle?" "Whoa." "Lights out in the suburbs is... is really dark." "MARSHALL:" "Where's the fuse box?" "LILY:" "I don't know." "(beep)" "(singsongy):" "I know where it is." "Maybe I could fix it for you, if I wasn't so busy packing." "MARSHALL:" "You know what?" "I bet the fuse box is in the basement." "I'll just..." "I'll go find it myself." "How hard can it be?" "(Marshall groans)" "As hard as that desk you just walked into?" "(guffawing)" "Good burn, Mickey." "You deserve a little nightstand fudge for that one." "KEVIN:" "Where do I look?" "I mean, I can't look at her chest." "Damn it!" "I just did." "Maybe Robin didn't notice." "Man, he's really up in those jugs." "Shake it, baby!" "A playa's gotta play!" "This is weird." "I'll just look her in the eyes." "Is he falling in love with this stripper?" "Quick, do something cool." "Make it rain, son!" "Money ain't no thang!" "Damn it, there was a 20 in there." "(chimes tinkling)" "MICKEY (over intercom):" "Hello, Mr. Eriksen." "From the sound of the wind chimes," "I hear you've made it to the first floor." "Okay... you know what, Mickey?" "You can save the creepy game master routine." "It's only kind of terrifying me." "Oh, but the game has just begun." "I call it "Try Not to Bang into All the Furniture and Stuff on Your Way to the Fuse Box in the Basement, Marshall."" "That's just a working title." "Hey!" "Got a little boob glitter on your eyebrow, Mac Daddy." "Straight pimpin'." "Barney, you got a little bit, too." "Where?" "Did I get it?" "Yeah, you got it." "Who needs Marshall and Lily?" "We got a new gang, and we're all going to hang out together forever." "My shift is done." "Good-bye." "Wait, stop!" "Technically, this song's not over, so we still own you." "Plus we're best friends!" "Where to next?" "We go to underground poker game in mostly-abandoned insane asylum." "Yes!" "This is gonna be awesome, and when it is, I want you all to remember who led you there:" "Barney Stinson, new group leader." "(giggles) Yay!" "I'm winning all your chippies!" "Let's not drink when we're..." "I'm thirsty; it's good." "It's good." "(intercom beeps)" "LILY (over intercom):" "Marshall, I just remembered" "I saw a box of matches in the drawer by the trash can." "Okay, thanks, baby." "Lily, I can't find them." "Looking for these?" "(evil chuckle over intercom)" "Oh, right, you can't see me." "Um, well, I'm burning the matches you so desperately need." "(evil laugh)" "Aah, ooh, ow!" "(over intercom):" "Ow." "Hah!" "Oh!" "(laughs)" "Mickey... guess who found the basement stairs?" "I'll be down at that fuse box in no time, and when I get there," "I'm sure that I'll figure out how fuse boxes work, so it'll be fine." "MICKEY (muffled):" "Hey, Marshall," "I know I've been messing with you, but seriously, that second step, don't..." "I don't want to hear it, Mickey." "(yells)" "(yelling and crashing)" "Oh, my knee!" "(cymbals crash)" "Ow!" "(sighs) And watch out for my drum set." "I win again!" "I was bluffing." "I didn't even have enough cards." "Ted, please stop winning." "Hey, look, it's the New York City skyline." "♪ We built Chip City" "Uh, uh!" "♪ We built Chip City on all your dough ♪" "♪ Built Chip City Hit it!" "(high-pitched whine)" "You know Butterfly-knife." "I'd expect this from Face Tattoo... or Jagged Cheek Scar, or Larry, but not you." "Why don't I get nickname?" "Because you have too many things, Larry." "You get one thing!" "(squeals)" "(speaking Russian)" "See, that's why you bring New Marshall." "(high-pitched laugh)" "We go to party in slaughterhouse." "You come?" "Please, God, no." "(sobbing):" "Don't let me be in charge of the gang anymore." "I can't believe Dr. Kevin doesn't remember me from our sessions three years ago." "Is that the lunatic that stabbed all those prison guards?" "We gotta hit that party!" "(quietly):" "I'll never find love." "We got to hit that party!" "BOTH (weakly):" "Sweet." "Lily?" "I think we made a mistake moving out to the suburbs." "I miss our home." "I miss our booth with our friends." "(cymbal crashes)" "And I'm pretty sure I have a drumstick... somewhere bad." "Dad, why are you acting like this?" "Well, I was just trying to be helpful, but you guys want me out by the Fourth of July." "Tomorrow." "(sighs)" "You know what a helpful father, not to mention grandfather, might do?" "Get these lights back on." "(sighs quietly)" "(intercom beeps)" "Okay, Marshall, listen up." "I'm gonna get you to that fuse box." "Can't you just come down here and do it for me, please?" "I don't know anything about this house." "No, Marshall... you don't know anything about your house." "All right, we got a lot of work to do." "Wait here, we get you on VPI list for party." "You give us, uh, $200 per person." "Cover charge." "That's pretty steep for a cover charge." "Is very good party." "Is party for, uh, New York "Yunkees" and Coca-Cola." "Oh, my God." "A Coca-Cola Yankees party?" "That sounds like a real thing." "Okay, now, Marshall, take three steps forward, while ducking underneath the broken ceiling fan." "Now look to your left and spit." "(spits, sizzles)" "That's the water heater." "Want to stay away from that." "That baby is hotter than the Widow Rodriguez in a unitard." "Okay, now past the washer and dryer is the hardest part." "You're gonna have to belly-crawl underneath the ping-pong table and don't so much as nudge it." "Why not?" "Because there are 900 dominos set up in the shape of Barbara Eden." "Big, big I Dream Of Jeannie fan." "I'm clear." "(thud, dominos falling)" "(dominos continue falling)" "I don't know what that sound is, Mickey." "That's the sound of Barbara Eden never banging me." "That's what that is." "Dad, get it back." "(quietly):" "Come on." "(beep) Okay, Marshall, take three steps forward, and you should be at the fuse box." "Do you think he made it?" "I did it!" "No, Marshall... you did it." "NARRATOR:" "Fun fact: that night inspired" "Mickey's one and only successful board game" "♪ With splintery floorboards and rusty nails ♪" "♪ Make sure you don't get impaled ♪" "♪ Lites Out!" "MICKEY:" "Brought to you by Aldrin Games!" "Well, judging from how many clients that hooker has serviced," "I'd say we've been here almost an hour." "Ted, we've been robbed." "Better Lily and New Marshall would never rob us." "They're our best friends." "(squealing)" "(speaking Russian)" "Damn it, Ted." "New Marshall is an escaped zoo bear and the only thing that Better Lily is better at than our Lily is over-the-pants hand stuff." "I'm assuming." "I'll admit it." "I can't lead this group." "We need Marshall and Lily." "But they're gone, aren't they?" "I mean, it'll go from seeing them a couple times a week, to a couple times a month, and then it'll just be holiday parties." "Then the years pass, and you find out Marshall's dead, and you're there for Lily emotionally at first, but then it becomes sexual, and you feel guilty, but maybe that guilt just makes it dirtier and better..." "No, I won't let that happen." "Especially that last part." "Look, I know I've been a little drunk and naive tonight, but here's what's gonna happen." "First, we're gonna leave a note for Better Lily and Arvydas, they're worriers." "Oh, buddy." "Then, we're gonna go see Only Marshall and One-Of-A-Kind Lily because they're our best friends and they're only 46 minutes away." "Are you with me?" "Kind of resent the power grab, but okay, let's go!" "Hey, do you want to come to Long Island with us?" "Uh, well, still a few more hours before the sun comes up." "BOTH:" "So..." "No." "No?" "Is that bad?" "(exhales) No, it's great." "Ooh, that felt so good." "I hate doing things and going anywhere!" "Oh, new experiences suck!" "(laughing)" "While we're at it, I hate high-fiving you!" "I know." "We're adults who are sleeping together, not teens pledging a frat." "Oh, man, I really liked the high-five." "NARRATOR:" "The next morning, Marshall and Lily woke up to a surprise." "(wind chimes clatter)" "Hey, what are... what are you guys doing here?" "Just wanted to make sure this key worked." "(sighs) We missed you." "Give mama a hug." "ALL:" "Oh..." "Don't check your voicemail." "Y-You might have a couple weird ones." "You hear this?" "!" "This is the sound of me moving on." "(whooping)" "(giggles)" "Yeah, I'm a stripper." "Okay, who wants pancakes?" "(gasps)" "Which two of you want pancakes?" "I'll make more." "Oh, good-good-good, 'cause I want pancakes." "There you go." "Thank you, okay." "Enjoy them." "Hey, honey, look," "I'm sorry I was a jerk before." "Okay?" "I'll leave right after breakfast." "I'll crash with some friends." "Dad, you know what?" "You can stay." "Oh, thank God." "I got no friends." "I'll be here two weeks, tops." "NARRATOR:" "It wasn't two weeks." "Would the five of us always live within a few minutes of that booth?" "No, that's life, kids, but here's what I discovered." "Our booth was wherever the five of us were together." "== sync, corrected by elderman ==" "That's right, Widow Rodriguez." "Stretch it." "Work those gams." "Ooh, yeah." "Grab that left arm." "Clutch that chest." "Fall down really fast." "Oh, my God!" "Somebody call 911!"

A highly unsettling phenomenon has been sweeping through our television news programmes of late. The phenomenon may have been inspired by the behaviour of that rude, horse-faced dreep, Jeremy Paxman. Or its origins may go back even further to the bad-tempered, dismissive approach of the singularly curmudgeonly Robin Day, he of the ridiculously oversized, spotted bowtie.I’m referring, of course, to the aggressive interview, particularly of politicians. The Paxo style of interview – attack like a Rottweiler from the off, never let up, and then when your victim is bleeding and defeated smile sweetly and say thank you – seems to have spread to all the news presenters. Even that cloying, homely Fiona Bruce – she of the Blue Peter school of presentation, with her constant hand gestures and undulating voice – is at it.Although tucked away on its News Channel, the BBC actually devotes a whole programme to the phenomenon. HARDtalk (the ominous uppercase letters are the BBC’s, not mine) is billed as: In-depth interviews with hard-hitting questions and sensitive topics being covered. Recently, I caught the tail-end of an interview on that programme with 98-year-old Ben Ferencz, the last surviving prosecutor at the Nuremberg trials. I ask you, hard-hitting questions directed at a man who has more gravitas in his pinkie than is possessed collectively by a studio full of self-important news presenters?Not long after that travesty, I also caught the tail-end of another broadcast on the programme. It was a cosy, self-congratulatory chat over lunch between the main presenters of HARDtalk, who were reminiscing on memorable interviews they had conducted over the years. One smug fellow recalled the time he interviewed the late Mo Mowlam when she was Secretary of State for Northern Ireland. (He spoke her name so disdainfully that he might as well have added the word “Oik” after it.) It seemed that the bold, brave (but clearly uncouth) Mo actually kicked him under the table when he pressed her to answer a particularly sensitive question. Oh, how they all laughed!I’m not against aggressive interviewing per se. What I object to are the aggressors. They are increasingly rude and surly to their interviewees. They have the arrogance to believe that it’s perfectly all right to impart their personal views, their personal values, with the rudeness and surliness. And they have the audacity to presume that they are representing the same views and values of their audience. Given that by and large the interviewers are ex-public school, ex-Oxbridge members of the upper middle-class, I hardly think they could ever represent my particular views and values. Yet I think they do believe their role is to act as the public’s moral guardians.So what can we do to combat this phenomenon of the aggro television interview? Perhaps if enough of us complain to Ofcom or sign a petition that’s debated in Parliament, the current pack of interviewers will receive a message from the public they haughtily presume to represent. You are not our moral guardians. We no longer wish to know what you think or what makes you angry and contemptuous. We wish to hear what your interviewees answer in response to your robust, probing questions. But we demand civility at all times in your approach. Above all, we demand objectivity.(While we’re at it, we could also get a message to BBC News. Get rid of Fiona Bruce – the woman is useless.)

Actigraphic monitoring during sleep of children with ADHD on methylphenidate and placebo. Sleep disturbances appear as a comorbid condition in children with attention-deficit/hyperactivity disorder. The aim of this study was to investigate the relationship of activity levels during sleep and therapeutic response to methylphenidate (MPH). Nightly sleep actigraphic recordings during a double-blind, placebo-controlled, crossover clinical study (1-week of 0.5 mg/kg MPH; 1-week of placebo) were obtained on 44 children, 6 to 12 years old, diagnosed with attention-deficit/hyperactivity disorder (DSM-IV). Significant (p <.005) differences between the conditions were found in several software-computed parameters: sleep onset latency (MPH, 39.3 minutes; placebo, 28.2 minutes), sleep efficiency (MPH, 78.0%; placebo, 80.4%), total sleep time (MPH, 7 hours; 57 minutes; placebo, 8 hours, 16 minutes). No significant differences on any of these measures were found among the 26 subjects who showed a moderate or large global improvement on MPH over placebo compared with 18 subjects who showed mild or no clinical improvement. MPH, given twice daily, induces a slight but significant sleep disturbance. Motor activity levels during sleep did not differentiate children who responded to MPH from those who did not respond. This suggests that responders to MPH treatment do not experience greater sleep disturbances than nonresponders, at least at the dose studied.

A typical adult does not brush his or her teeth adequately, nor does the typical adult floss his or her teeth with the frequency recommended by dentists. Gingivitis is usually caused by bacterial plaque that accumulates in the spaces between the gums and the teeth and in calculus that forms on the teeth. The bacteria produce foreign chemicals and toxins that cause inflammation of the gums around the teeth. This inflammation can cause deep pockets between the teeth and gums and loss of bone around teeth otherwise known as periodontitis. Since the bone in the jaws holds the teeth into the jaws, the loss of bone may cause teeth to become loose, and eventually fall out. If the inflammation in the gums becomes especially well-developed, it can invade the gums and allow tiny amounts of bacteria and bacterial toxins to enter the bloodstream. Studies suggest this can result in a generalized increase in inflammation in the body cause possible long term heart problems. Periodontitis has also been linked to diabetes, arterosclerosis, osteoporosis and pre-term low birth weight babies. Bacteria and bacterial toxins are carried by tooth brushes, and brushing alone may cause the germs to remain in the mouth if the tooth brush is not sanitized between uses. There is a need for a device that will hold and sanitize toothbrushes. The use of common antiseptic mouthwashes in combination with brushing, even if the brushing is otherwise inadequate, will kill harmful bacteria, and improve oral hygiene. The device should therefore encourage the use of mouthwash, and facilitate improved sanitation of toothbrushes.

Specific antismoking advice after stroke. Many stroke survivors would benefit from modification of their lifestyle in order to reduce their risk of recurrent stroke. We investigated if tailored smoking cessation advice would yield a higher smoking cessation rate and a higher rate with sustained abstinence in ex-smokers in the intervention group than among controls. Patients admitted with an acute stroke or a transient ischaemic attack were included in a randomised controlled trial focusing on control of lifestyle risk factors and hypertension. Here, we report the intervention focused on smoking cessation. We used multiple logistic regression analysis to identify patient characteristics associated with smoking cessation. Analyses were by intention to treat excluding those who died or suffered severe disease. We included 254 patients with a history of smoking. Two years after inclusion, 15 of 57 (26%) baseline smokers in the intervention group had stopped smoking versus eight of 56 (14%) among controls (p = 0.112). Living with a partner (p = 0.012), having at least ten years of education (p = 0.012), and not being exposed to smoking at home (p = 0.036) were independent predictors of smoking cessation. We did not achieve our aim of higher smoking cessation rates in the intervention group. Future smoking cessation interventions should be more intensive, focus on patients' social circumstances and, if possible, involve patients' relatives. This study was supported by the Ludvig and Sara Elsass Foundation, the Lundbeck Foundation and The Danish Heart Foundation (Grant 07-4-B703-A1378-22384F). This protocol is registered with Clinical Trials.gov (NCT 00253097).

This invention relates generally to the field of appliance control circuits and more particularly to a circuit including a microcontroller operable for monitoring the contact posture of an access door actuated switch. The microcontroller will prevent operation of the appliance if monitoring of the access door actuated switch indicates that the contacts have not been actuated between the open and closed postures during a predetermined period of time. The prior art relating to appliances has generally required that an access door actuated switch be in the closed posture before the appliance can be operated. Grabeck in U.S. Pat. No. 3,627,960, issued Dec. 14, 1971, teaches the closing of an access door to actuate a switch for conditioning the appliance control circuitry. In this system the switch must be closed to indicate a closed access door prior to operation. There is no teaching of a microcontroller for checking the posture of the switch and for ensuring that the switch contacts are operable between open and closed postures which is an indication of the condition or operability of the switch. Ellingson et al, in U.S. Pat. No. 4,510,777, issued Apr. 16, 1985 and assigned to the assignee of the instant invention, disclose an appliance controlled by a microcontroller. In this appliance, a first switch is closed when the access door is physically operated to a closed position. Closing the access door positions a latch member for locking the access door in the closed position. A solenoid is then actuated by the microcontroller to lock the access door and close the contacts of a latch switch to provide an access door latched signal to the microcontroller. This latch switch is interrogated by the microcontroller prior to actuating the solenoid for confirming the proper operability of the latch switch. The circuit does not, however, teach the direct interrogation of the access door actuated switch by the microcontroller for determining the proper operability thereof. It is believed that there has been no teaching of a microcontroller-based appliance control circuit wherein the microcontroller is operable for directly monitoring the contact posture of an access door actuated switch and for preventing operation of the appliance in the event that the switch is not functional.

Factor VIII (FVIII) is a protein found in blood plasma that acts as a cofactor in the cascade of reactions leading to blood coagulation. Hemophilia A is caused by a reduction or deficiency of functional FVIII protein and is one of the most common bleeding disorders that affects about 1 in 5000-10000 men. Clinical symptoms in hemophilia are frequent muscle and joint bleeds, and trauma can even lead to life threatening situations. Currently, effective treatments for hemophilia include replacing the missing FVIII protein using intravenous application of recombinant or plasma derived FVIII products. Such preparations are generally administered either in response to a bleeding episode (on-demand therapy) or at frequent, regular intervals to prevent uncontrolled bleeding (prophylaxis). Unfortunately, the appearance of neutralizing anti-FVIII antibodies (FVIII inhibitors) is a major complication during replacement therapy with FVIII products. Approximately 25% of the patients receiving treatment develop this immunity to FVIII protein, thus making further control of bleeding very difficult. The cause for this immune response to FVIII protein has not been fully elucidated, but the specifics of a patient's immune system can affect their response to therapy. Normally, the immune system develops a tolerance to certain antigens, e.g., “self” antigens. This feature is important because, otherwise, if a self antigen is recognized as a foreign antigen, autoimmune disease results. Hemophilia A patients, in particular, have a genetic defect in their FVIII gene, which causes the immune system to not recognize the administered FVIII protein as a “self” antigen. Thus, when FVIII protein is administered during coagulation factor replacement therapy, the patient's immune system recognizes the FVIII protein as a foreign antigen or an altered self protein and develops anti-FVIII antibodies accordingly. The FVIII inhibitors, i.e., anti-FVIII antibodies are produced by plasma cells derived from FVIII specific B cells. B cells need the help of activated CD4+ T-cells to proliferate and differentiate into anti-FVIII antibody producing plasma cells. For example, FVIII protein is recognized by B and T lymphocytes in different ways. The induction of anti-FVIII antibodies is T helper cell dependent. B cells recognize whole protein epitopes via their specific B cell receptor. T-cells on the other hand, recognize proteins in the form of processed peptides complexed with an MHC class II molecule presented on the surface of an antigen presenting cell. Each CD4+ T-cell clone recognizes only one specific peptide-MHC complex. For presenting the peptides to the T-cells, MHC class II molecules have an open binding groove that allows peptides of various lengths to fit in and be presented on the surface of a cell. Moreover, the MHC class II protein contains four binding pockets that differ for the various haplotypes (Jones et al., Nature Rev. Immunol. 6:271-282 (2006)). Only specific amino acids fit into these binding pockets, and the minimal size of binding peptides is nine amino acids. Notably, different MHC class II haplotypes can present different peptides. Thus, it is likely that a patient's MHC class II haplotype influences the risk of developing anti-FVIII antibodies. Indeed, several studies have shown that there is a correlation of the human MHC class II haplotype HLA-DRB1*1501 with an increased risk for anti-FVIII antibody development (Pavlova et al., J. Thromb. Haemost. 7:2006-2015 (2009); Oldenburg et al., Thromb. Haemost. 77:238-242 (1997); Hay et al., Thromb. Haemost. 77:234-237 (1997)). Certain approaches have been explored to address the challenges associated with treating hemophilia by administration of FVIII protein. For example, WO 03/087161 discloses modified FVIII proteins, in which the immune characteristics of the FVIII protein are modified by reducing or removing the number of potential T-cell epitopes present on the protein. A number of regions that include T-cell epitopes along the FVIII protein were identified, including, e.g., FVIII2030-2044. According to the disclosure, removal of such regions could be used to provide functional FVIII protein that did not induce production of anti-FVIII antibodies. WO 09/071,886 also discloses specific regions of FVIII protein that were predicted to give rise to HLA-DR2 binding peptides that are involved in a patient's immune response, such as, e.g., FVIII475-495 FVIII542-562, FVIII1785-1805, and FVIII2158-2178. The peptides were identified for possible use in inducing immune tolerance in a patient. While there have been advances in identifying regions of FVIII protein involved in the immune response, there is still a need to identify other regions of FVIII protein that can be used for developing other therapeutic peptides and methodologies that can, for example, be used to treat patients having hemophilia A.

The present invention relates to automatic sprayers for spraying cosmetic, medical or coating liquid. Conventionally, there have been known, for example, manually operated sprayers to be used in ironing, or automatic ones fitted with a prime mover to be used for spraying upon plants. In addition to the above, for the cosmetic treatment or coating purpose there have been also used sprayers of the type which are operated by pressure of liquefied gas sealingly contained together with spray liquid in a container. However, in many countries, restrictions are being imposed on the use of such sprayers in view of various troubles caused by gases used therein, and accordingly, the use of such typed sprayers may not be permitted in the future. The above-mentioned conventional manually-operated sprayers are constructed in such a way that a nozzle body is lowered by pressing action of the thumb, so as to cause the liquid to be sprayed, and after the nozzle body has been returned to the original position from the lowermost depressed position by force of a spring, such pressing may be repeated. Such sprayers have certainly advantages, for example, spraying may be carried out by moving the nozzle body upward and downward, thereby to permit liquid to be dispersed in a certain vertical range. However, operators will get very tired if trying to keep spraying continued, in that sprayers are manually operated and spring return action is utilized. On the contrary, automatic sprayers may enable continuous spraying at ease. However, such automatic sprayers have also defects; that is, in conventional automatic sprayers, a nozzle body is normally fixed to a spray body in a unitary construction, and spraying is not carried out in the pressing system of the manually operated type in which air is compressed by using a plunger, thereby to requiring an operator to direct the nozzle toward an object. Furthermore, such conventional automatic sprayers may produce spray of relatively larger particles than those obtained by manually operated sprayers of the type in which air is compressed by using a plunger. Accordingly, in spraying, for example, medical liquid with such sprayers, sterilizing effect may be reduced, thereby to necessitate manual scattering. On the other hand, in spraying coating material with such sprayers, efficient, thinnest and uniform coating may not be expected.

"So this is Cirra." "It's beautiful." "To me it's the ugliest place on Earth." "I don't think you should keep punishing yourself for what happened." "I didn't come here to punish myself." "I wanna understand why." "Why what?" "Why it happened." "Why I was, who I was." "And how I can ever atone." "You've changed, Xena." "Like this valley." "Once it was a place full of death and violence." "But now it's full of beauty and life." "The same kind of change has happened to you." "I wish that I could see it that way." "I'm going down there." "I'll wait here." "Why?" "Gabrielle!" "Gabrielle?" "Lord of the moon, mistress of the stars..." "We, the children of the sun, ask you for an omen." "Send us a sign." "Hail Goddess!" "We are your servants." "Tell us our future." "I got nothing but bad news for you." "Gabrielle, catch!" "Run!" "Come on, run!" "Gabrielle?" "Wait!" "Wait!" "Stop!" "I think I hear Xena." "Hey..." "Glad to see ya." "Now get outta here." "Quick!" "Run!" "Come on, don't stop!" "Let's go!" "Get her!" "Get out of the way!" "In the time of ancient gods..., warlords and kings, a land in turmoil cried out for a hero." "She was Xena." "A mighty princess forged in the heat of battle." "The power." "The passion." "The danger." "Her courage will change the world." "XENA" " WARRIOR PRINCESS" "Xena..." "Open your eyes." "Wake up!" "Wake up!" "Gabrielle, the girl." "What girl?" "One of the captives?" "Only she can save me." "They're gone!" "Xena..." "Mount Nestus..." "Oh, I'm sorry." "Mount Nestus?" "Take me there." "I..." "I can't take you there, I don't know..." "It's too far away." "Xena, I..." "I don't know if..." "Please..." "Ok." "Amphipolis..." "TEN WINTERS AGO" "Come on!" "Get moving!" "Have mercy!" "Please!" "Come on, get on over to Xena!" "People of Neopolitis." "Friends, you're free to go." "But spread the word." "My army will punish any village that allies itself with the enemies of Amphipolis." "And I will do anything to ensure the safety of my homeland." "Those who don't heed my warning will pay a terrible price." "Get going!" "You hungry?" "Ah, what's the matter?" "You not hungry?" "I generally don't eat food touched by a pig." "You have a woman's touch." "So, you not afraid of a beating, huh?" "You afraid to die?" "A brave man dies only once." "A man like you dies a thousand times." "All right, brave man." "You're one time is now!" "Tellus..." "Look at him." "The robes The bearing, the poise..." "Why, we have a roman nobleman." "A valuable commodity." "What are you talking about?" "Ransom." "She's talking about ransom, pig." "That's right, we can get 20.000 dinars for him." "20.000 isn't enough." "Oh, really?" "They'll never believe you have me, if that's all you're asking." "I'm worth five times that." "Very well..." "But if you're wrong, it's your neck." "Lyserius..." "Send out a ransom demand to the nearest roman settlement." "Tell them to send 100.000 dinars if they ever want to see..." "What's your name?" "Caesar." "Julius Caesar." "Caesar." "Julius Caesar, again." "You really weren't afraid to die, were you?" "I knew someone would stop him." "And how could you know that?" "I know what I'm fated to do with my life." "And what's that?" "Rule the world." "Let's go, roman." "Xena?" "Can you hear me?" "Xena!" "Xena, can you hear me?" "Mount Nestus." "Is it north of the Strymon river?" "North..." "Strymon..." "I think that's a yes." "Do you hear me?" "Don't make a move." "What is it?" "We have a stowaway." "Come down!" "We got her." "Hold onto her." "A woman." "What did you do to my leg?" "Fix it!" "My leg, fix it!" "Bring over Tellus." "She can fix whatever she did to him." "What's she saying?" "She said it's too late for him." "She's killed him!" "Wait." "You speak her language..." "Tell her I'll spare her life if she'll teach me how she did that." "Take her down below." "Let's go!" "Be careful." "Runaway slaves are very dangerous people." "How do you know she's a runaway?" "She speaks gaelic." "But she's clearly from the land of the Pharaoh." "Probably abducted as a child by raiders from Western Gaul." "Western Gaul, huh..." "Why do you say that?" "Gaul is divided into three parts." "Each area speaks its own different dialect." "One day I'll conquer all three provinces." "How can you be so sure of yourself?" "I told you, I'm..." "Oh, that's right." "You're fated to rule the world." "Do you really believe that?" "Of course." "Each event in our life is part of a great plan." "There are no accidents, only destiny." "And who shapes this destiny?" "The gods?" "Perhaps." "Or it's the blood in our veins, our souls Our desires, our will." "They're all in it together, weaving a tapestry we call destiny." "Well, I can tell you one thing about your destiny." "You're fated to have dinner in my cabin tonight." "Grab his legs!" "Show me that thing you do." "No." "Not on my leg." "Show me on my neck." "Yeah..." "Come on." "That was too fast." "Now take it off and do it again, slower." "Take it off." "Come on!" "You got some sense of humor." "Now, teach me how you did that." "No, not on me." "Teach me on yourself." "Here?" "You see, I can play, too." "Come on." "Where did you steal that dress?" "Stugeira." "Maybe someday, you can go back for the rest of it." "Are you complaining?" "No, not at all." "It's lovely." "Why Stugeira?" "It's the ancient enemy of my home village, Amphipolis." "Amphipolis?" "So all your raiding and looting is about protecting your homeland." "That's right." "It was once brutally attacked by a warlord." "But I've made sure that'll never happen again." "And what about you?" "What about me?" "What drives you?" "The desire to be great." "You mean powerful." "No." "Greatness isn't just about possessing power." "If it was, any thug with an army would be entitled to that label." "Greatness is about achieving what seems impossible... to other men." "Why don't you and I work together?" "What do you mean?" "This life I'm living is beginning to bore me." "I'd love to join forces with you." "So, you wanna help me conquer the world..." "Why not?" "We'd make an unstoppable team." "Indeed." "I bet you know a lot..." "about conquest." "Yes I love it." "Pursuing the enemy, breaking down his defenses Cutting off his only path of retreat and then closing for the kill." "Some enemies are harder that others." "Oh, I count on it." "What's the matter?" "Not all there?" "No." "I was just wondering if we'll ever see one another again." "A moment won't pass when I'm not thinking about you." "Now go." "I'll find you, I promise." "Ship ahoy!" "Bring her around!" "We're going to join them!" "It's all right." "He's my friend." "Hurry up!" "Now!" "What do you think you're doing?" "This is my destiny." "You're a part of it." "And I'm a part of yours." "The ship is secured, Caesar." "Good." "Where's that friend of yours?" "The gaelic slave girl..." "I had to kill her!" "Because she betrayed me!" "Really?" "Well, I don't blame you." "Still, she would have fetched a good price with the gladiator dealers." "Is that what you have planned for me?" "We were going to conquer the world together, what happened to those plans for us?" "Us?" "There was never any "us", Xena." "Only Rome." "And I am Rome." "Still Don't think that what we had was meaningless." "I'll always remember it." "And you'll have a special place of honor among my conquered." "She was an easier prey than I expected." "Divide and conquer, my friend." "You divide a woman's emotion from her sensibilities and you have her." "I could've sold you and all your friends into slavery, Xena." "But that's what any common warlord would do." "But with this and especially with you I defy myself to all those who would dare oppose me." "All those who would dare prey on Rome." "Goodbye, Xena." "Break her legs." "Sleep." "You're getting worse." "Who goes there?" "I asked you a question!" "The Senate will never approve the funds for a northern invasion." "You move too fast, Caesar." "Time is on your side, take advantage of it." "I shall." "And my time is now." "The plunder I have taken from these pirates makes it so." "I can finance my invasion without the approval of the Senate." "And with victory, the army will pledge allegiance." "And Rome will be mine." "No, Brutus." "From this moment on, I am no longer subordinate to old men in white robes." "I'm their rival." "What is this?" "Caesar, the barbarian woman." "The one name Xena, escaped." "Your life is forfeit." "That you already know." "But you can redeem yourself." "Take my centurion guard and find her." "I want her lifeless body brought back to me by the end of the night." "Go." "What is this?" "Nicklio!" "Are you a healer?" "You could say that." "I'm the healer." "Please..." "Please, help me." "Please, help me." "My friend, she needs help." "Xena?" "What happened to her?" "Her organs are swelling from internal bleeding." "Nicklio..." "Don't, please..., ...let me go." "I've just reset your bones." "You're lucky M'Lila brought you here." "Yeah, lucky." "M'Lila, huh?" "Ask her why she saved me." "She says it's not your time to die." "Well, if not now, then when?" "Let me see your wound." "Will you help my friend." "Xena can wait." "You, I can do something about." "What do you mean?" "You have amazing recuperative powers." "How are you feeling?" "Fine." "Much stronger." "Those needles are fascinating." "M'Lila..." "Up on that cross I wasn't sure that I wanted to live." "You had no reason to save me but you did." "Thank you." "I know you can't understand." "She wants to know if you feel anger towards Caesar." "There she is!" "Get her!" "Something's happening." "Her pulse is failing." "You'll be dead in 30 seconds." "But know this, you won't be the last." "She's gone." "She can't be gone." "Tell Hades to prepare himself." "A new Xena is born tonight." "With a new purpose in life." "No!" "Death." "No!" "Let her pass over." "Please..." "Please, wake up." "Wake up!" "Wake up!" "Please, wake up." "Do something!" "Do something!" "M'Lila..." "Hello, Xena." "You should have left me to die back there on that beach." "You have a destiny, Xena." "But you have to choose it." "I did choose it!" "I chose evil." "Now that you know evil..., ...were evil, you can fight evil." "When the living think of the dead the dead can hear their thoughts." "Listen." "Xena, I know you can hear me." "Wherever you are..." "I know you always told me to be strong." "I can't be, not now." "You can't leave me!" "I know it's not your time." "I can feel it in my heart." "I feel this emptiness that I've never known before and it scares me." "Xena, above all, just remember your destiny." "Remember it and fight!" "Just fight to come back." "This world needs you." "I need you." "I have to go back." "TO BE CONTINUED..." "Subtitles: @marlonrock1986 (^^V^^)"

Alcohol is the most commonly abused drug in the world. In the United States about half the adult population regularly consumes alcohol. It has been well established that alcohol has harmful effects on the lung. For example, heavy alcohol intake increases the risk for developing pulmonary diseases such as pneumonia, bronchitis and acute respiratory distress syndrome (ARDS). The first line of defense of the conducting airways is the airway epithelium, which contains tight junctions and expresses Zonula occluden-1 (ZO-1), and occludin. Claudin-1 is a transmembrane protein, which is important in regulating tight junction permeability claudin-1, . ZO-1 is a peripherally associated membrane protein, which links tight junction proteins to the actin cytoskeleton, other tight junction proteins (claudin and occludin) and is believed to be an important component in stabilizing tight junctions. Tight junctions are characteristically located at the apical-lateral borders in airway epithelium where they regulate cell polarity and act to selectively regulate the passage of water, ions, neutral molecules and inflammatory cells through the paracellular pathway. A number of studies have shown that alcohol disrupts tight junctions resulting in barrier leak. In the lung this occurs in the parenchyma compartment resulting in pulmonary edema and alveolar edema. Tight junctions also play a key role in regulating the barrier function in the conducting airways. Airway leak is a cardinal feature of airway diseases such as bronchitis and asthma. Increased leak contributes to airway edema, which is a classic finding of these diseases. However, little is known about the effects of alcohol in the conducting airways. We have recently observed that alcohol impairs ZO-1 and claudin-1 translocation to the cell membrane and increases tight junction permeability resulting in leakier airway epithelial cells. Our data link this leakiness to alcohol-induced changes in airway protein kinase C (PKC) activation resulting in impaired protein translocation to the cell membrane. These findings led us to hypothesize that: Alcohol promotes airway leak linked to the delocalization of ZO-1 and claudin-1 through a PKC-dependent pathway in the airway epithelium. We propose to test this hypothesis with 3 specific aims: 1) Determine the functional consequences of alcohol on tight junctions in the epithelium of the conducting airways; 2) Define the mechanism through which alcohol impairs ZO-1 and translocation; 3) Establish the impact of alcohol-triggered ZO-1 and rearrangement in an in vivo model of alcohol-fed mice. Results for these studies will improve our understanding of the impact alcohol has on airway epithelial barrier functions, which are critical for the understanding and treatment of airway diseases common among alcohol abusers. claudin-1 claudin-1 )

Automotive heat exchangers, such as radiators, heater cores, evaporators and condensers are predominantly made of aluminum alloys to reduce the weight of the vehicles. These heat exchangers can be the tube and fin type where the fins are corrugated and/slotted at right angles to the direction of airflow. In the past, mechanical expansion techniques have been used for mass-production of automotive finned-tube heat exchangers. Heat exchangers are now predominantly formed by a brazing operation, wherein the individual components are permanently joined together with a brazing alloy. Since the early 1980s, one brazing technique known as controlled atmosphere brazing (CAB) has become increasingly popular for use by automotive industry to make brazed aluminum heat exchangers. CAB has been preferred over a previous brazing method, i.e., vacuum furnace brazing, due to improved production yields, lower furnace maintenance requirements, greater braze process robustness, and lower capital cost of the equipment employed. When manufacturing the heat exchangers using the CAB process, an aluminum brazing filler alloy (e.g., AA 4345 or AA 4043) is often pre-cladded or coated on at least one side of the core aluminum alloy sheet (or brazing sheet). Alternatively, a prebraze arc sprayed zinc coating is applied on the non-clad tubes (e.g., via a wire arc spraying process) to improve their corrosion resistance. The aluminum core alloys of the fins and tubes are typically AA 3003 or various “long life alloys” or modified AA 3003 alloys with additions of small amounts of elements typically selected from Cu, Mg, Mn, Ti, Zn, Cu, Cr and Zr. In the CAB process, a fluxing agent is applied to the pre-assembled component surfaces to be jointed. During brazing at approximately 560 to 575° C., the fluxing agent starts to melt and the melted flux reacts, dissolves and displaces the aluminum oxide layer that naturally formed on the aluminum alloy surface and frees up the brazing filler alloy. The brazing filler alloy starts to melt at about 575 to 590° C. and begins to flow toward the joints to be brazed. During the cooling process, the filler metal solidifies and forms braze joints. The flux present on the surface also solidifies and remains on the surface as flux residue. Additional functions of the fluxing agent are to prevent reformation of an aluminum oxide layer during brazing, enhance the flow of the brazing filler alloy, and increase base metal wettability. The fluxing agent is typically a mixture of alkaline metal fluoroaluminates with general formula K1-3A1F4-6.xH2O, which is essentially a mixture of K3AlF6, K2AlF5 and KAlF4. Fluoride-based fluxes are preferred over chloride-based fluxes for brazing aluminum or aluminum alloys because they are considered to be inert or non-corrosive to aluminum and its alloys, and substantially water insoluble after brazing. When the recommended flux coating weight (3-5 gram per square meter (g/m2) for furnace brazing) is used, the CAB process is said to generate a 1-2 micrometers (μm) thick tightly adherent non-corrosive residue. Hence, it is believed that no removal of the flux residue is necessary after the brazing operation. Due to the reported non-corrosive nature of the flux, its tolerance to brazing assembly fit-up and flexible control, CAB is one of the lowest cost methods for the joining of aluminum heat exchangers. It is now commonly used by the automotive and other industries for manufacturing of heat exchangers.

The family of light-harvesting-related proteins (LHCs, ELIPs, HLIPs): was the harvesting of light their primary function? Light-harvesting complex proteins (LHCs) and early light-induced proteins (ELIPs) are essential pigment-binding components of the thylakoid membrane and are encoded by one of the largest and most complex higher plant gene families. The functional diversification of these proteins corresponded to the transition from extrinsic (phycobilisome-based) to intrinsic (LHC-based) light-harvesting antenna systems during the evolution of chloroplasts from cyanobacteria, yet the functional basis of this diversification has been elusive. Here, we propose that the original function of LHCs and ELIPs was not to collect light and to transfer its energy content to the reaction centers but to disperse the absorbed energy of light in the form of heat or fluorescence. These energy-dispersing proteins are believed to have originated in cyanobacteria as one-helix, highly light-inducible proteins (HLIPs) that later acquired four helices through two successive gene duplication steps. We suggest that the ELIPs arose first in this succession, with a primary function in energy dispersion for protection of photosynthetic pigments from photo-oxidation. We consider the LHC I and II families as more recent and very successful evolutionary additions to this family that ultimately attained a new function, thereby replacing the ancestral extrinsic light-harvesting system. Our model accounts for the non-photochemical quenching role recently shown for higher plant psbS proteins.

Academic and Social Benefits of a Co-enrollment Model of Inclusive Education for Deaf and Hard-of-Hearing Children. Deaf and hard-of-hearing (d/hh) students are traditionally educated within self-contained programs at residential or special day schools, within self-contained or resource classrooms in public schools, or within regular education classrooms with support provided by an itinerant teacher. The co-enrollment model offers a promising alternative in which these students are educated within a regular education classroom composed of both d/hh and hearing students and team-taught by a teacher of the deaf and a regular education teacher. This article examines the development of one such program and the social and academic performance of the d/hh students within the program. Data on social interaction between d/hh and hearing classmates suggest that specific instructional strategies that promoted students' sign language development, identified d/hh students as "sign language specialists" and grouped d/hh and hearing students during academic activities resulted in increased interaction between these two groups of students. Stanford Achievement Test scores in the areas of reading vocabulary, reading comprehension, mathematical problem solving and procedures indicate that although d/hh students scored below the national normative hearing group, reading comprehension levels exceeded the national normative sample of d/hh students during both years two and three of the program. We discuss the challenges of implementing a co-enrollment program.

High diagnostic yield and accuracy of history, physical examination, and ECG in patients with transient loss of consciousness in FAST: the Fainting Assessment study. Transient loss of consciousness (TLOC) is a common clinical problem. The aim of this study was to assess the yield and accuracy of the initial evaluation, consisting of standardized history, physical examination, and ECG performed by attending physicians in patients with TLOC. Five hundred and three adult patients (mean age 53 +/- 19; 56% male) presenting with TLOC to the Academic Medical Center Amsterdam between February 2000 and May 2002 were included in this study. After initial evaluation, the physician made a certain, a highly likely (>80% certain), or no initial diagnosis. Initially undiagnosed patients received additional cardiological testing, additional history taking, and autonomic function tests. After 2 years of follow-up, an expert committee determined the final diagnoses. Two-year follow-up was obtained in 99% of the patients. The yield of certain diagnoses after the initial evaluation was 24%, increasing to 63% after including the highly likely diagnoses. The diagnostic accuracy of the initial certain diagnoses was 93% (95% CI 87-97%), decreasing to 88% (95% CI 84-91%) after inclusion of the initial highly likely diagnoses. Attending physicians can make a diagnosis based on initial evaluation in 63% of patients with TLOC, with an overall diagnostic accuracy of 88%. The use of additional testing, beyond history, physical examination, and ECG can be avoided in many patients with TLOC.

Identifying women at risk for inherited breast cancer using a mammography registry. Women at risk for inherited breast cancer have been identified for intervention studies through newly diagnosed relatives or from volunteers with a family history. This pilot study tested the use of a mammography registry to identify women at risk. Fifty women with first-degree relatives diagnosed as having breast cancer before age 45 were randomly selected from the Vermont Breast Cancer Surveillance System. Thirty-three women (66%) completed a phone interview that included a three-generation family pedigree of breast and ovarian cancers. Fifty-one percent of the women were at higher risk for inherited breast cancer based on the family history. Eighteen percent of the first-degree relatives' breast cancers were pathologically confirmed. Mammography registries that collect similar family history data may be used to identify women at risk for inherited breast cancer. Many intervention studies would require improved methods to obtain pathologic confirmation.

Field of the Invention: The present invention relates generally to systems for monitoring environmental conditions and, more particularly, to detection of environmental conditions in buildings that are conducive to fungal growth. State of the Art: There is a growing concern about fungal contamination in both residential and commercial buildings. To address this concern, there is a need for a system that detects environmental conditions conducive to growth of some of the most common fungal types found in contaminated buildings. Fungal contamination in buildings and the subsequent exposure risk to inhabitants is an increasing concern to builders, property managers and owners, and the property insurance companies that issue coverage. Although the low cost of laboratory analysis has made accurately assessing fungal contamination in residences and buildings possible, the associated costs of remediating fungal-contaminated buildings remains high, due to specialized practices and procedures not found in conventional demolition and construction. In light of this, we sought a method by which the conditions for permissible fungal growth could be detected and corrected before fungal contamination occurs. Generally, fungi require nutritious media, moisture, and mild temperatures to grow. Although nutritious media and mild temperatures are often found in living and working spaces, relative humidity and surface moisture are often too low for fungal growth to occur. In walls, roof/ceilings, and other plenum spaces however, these contained areas create an environment favorable for mold growth and thus these spaces represent the highest risk for mold development. Indeed, plumbing, appliance, and roof leaks in plenum areas are often causes of loss leading to fungal contamination in a building. The moisture requirement for fungal growth is fulfilled by accidental water incursions, and can be artificially divided into fast, catastrophic leaks and slower leaks. Although catastrophic leaks typically result in the greatest water-related damage, their very nature results in relatively rapid detection and subsequent prevention or remediation of fungal contamination, if handled expeditiously. Slow water incursions such as those related to HVAC system issues, leaking appliances, groundwater incursions, plumbing leaks, and roof leaks are of particular concern, since inhabitants do not always readily detect them. A small unobtrusive and inexpensive device is needed for detecting these relative humidity levels conducive to fungal growth. In addition, a method and device are needed for analyzing the relative humidity values. Results of the analysis may be reported to a user through a visual and auditory interface or to a host device through a network interface. In one preferred embodiment of the present invention, a device and method collect and log relative humidity, and evaluate that data using an algorithm to determine if local environmental conditions are conducive for fungal growth of potentially toxicogenic species of Aspergillus, Penicillium, and Stachybotrys, molds commonly found in the United States. The device and method detect conditions conducive to the growth of several species of fungus (mold) and not necessarily mold itself. In one embodiment, the device, a fungus growth condition meter, is placed in a wall, floor, or ceiling to detect relative humidity levels within the wall or attic cavities. It is particularly useful for placing in xe2x80x9cwetxe2x80x9d walls where plumbing exists and the danger of pipe leakage makes a fungal growth condition more probable. The device may be configured in a cylindrical shape, similar to a hockey puck, or as a rectangular cube suitable for placing in a standard electrical box such as those used to house AC electrical current outlets. A panel on the front of the device indicates growth conditions within the cavity to a user. The interface may comprise a visual alarm, such as a blinking light emitting diode LED, an audio alarm, and a display indicating up to five different levels of relative humidity conditions. The growth condition meter may include a simple controller with attached memory, a timer, a relative humidity sensor, and the user interface. The timer keeps track of the time of day and creates a fixed time interval at which relative humidity values are sampled using the relative humidity sensor. In addition, the growth condition meter may contain a network interface for connection to a host computer allowing the creation of a network of growth condition meters positioned throughout a building. The host computer may be a standard personal computer, a computer specifically designed for the task of monitoring growth condition meters, or possibly even a personal digital assistant (PDA) or similar device. In one preferred embodiment, the device executes an algorithm for determining growth conditions within the cavity based on a history of relative humidity samples. To begin the process, the growth condition meter gathers enough samples at a predetermined sampling interval to complete a 24-hour period of aggregate samples. The algorithm then compares the relative humidity samples to predetermined relative humidity thresholds to determine a severity level for fungal growth. The algorithm uses a two-part analysis rubric. First, the algorithm uses a temporal analysis rubric. This analysis examines all consecutive samples over the previous 24-hour period to determine how long the relative humidity was below a predetermined threshold. Relative humidity levels will typically by cyclical, following a roughly sinusoidal profile over a 24-hour period. By examining consecutive relative humidity values below a fixed threshold, the algorithm can verify that relative humidity is varying in relation to environmental conditions. Additionally, the algorithm verifies that enough time is spent below the threshold creating a thermal burn-off of the humidity to an extent that mold growth is not probable. The threshold level is set to a predetermined programmable value based on environmental conditions where the growth condition meter is installed. Example historical data collected in Houston, Texas indicate that, for the Houston area, a relative humidity threshold of about 80% would be appropriate. The second rubric is a baseline analysis comparing all samples over the previous 24-hour period to determine if all samples are over a predetermined relative humidity threshold. The baseline rubric allows for a scenario where there is enough time spent below the temporal threshold but the overall relative humidity remains high enough to permit fungal growth. Comparing the relative humidity values to three different threshold levels creates a gradient severity level based on this baseline analysis. The threshold levels are set to predetermined programmable values based on environmental conditions where the growth condition meter is installed. Example historical data collected in the Houston, Texas area indicate that, for the Houston area, appropriate threshold levels are 75%, 70%, and 65%. The algorithm combines the results of both analysis rubrics to arrive at a composite severity level, which it then reports to the user through the user interface or to a host computer through the network.

Electrochemical determination of methimazole based on the acetylene black/chitosan film electrode and its application to rat serum samples. A novel method has been developed for the determination of methimazole, which was based on the enhanced electrochemical response of methimazole at the acetylene black/chitosan composite film modified glassy carbon electrode. The electrochemical behavior of methimazole was studied at this film electrode by cyclic voltammetry and differential pulse voltammetry. The experimental results showed that methimazole exhibited a remarkable oxidation peak at 0.63V at the film electrode. Compared with the bare glassy carbon electrode, the oxidation peak current increased greatly, and the peak potential shifted negatively, which indicated that the acetylene black/chitosan film electrode had good catalysis to the electrochemical oxidation of methimazole. The enhanced oxidation current of methimazole was indebted to the nano-porus structure of the composite film and the enlarged effective electrode area. The influences of some experimental conditions on the oxidation of methimazole were tested and the calibration plot was examined. The results indicated that the differential pulse response of methimazole was linear with its concentration in the range of 1.0×10(-7) to 2.0×10(-5)mol/L with a linear coefficient of 0.998, and in the range of 4.0×10(-5) to 3.0×10(-4)mol/L with a linear coefficient of 0.993. The detection limit was 2.0×10(-8)mol/L (S/N=3). The film electrode was used to detect the content of methimazole in rat serum samples by the standard addition method with satisfactory results.

The present invention concerns a process enabling the direct fabrication of at least one part on a structure, in particular an aircraft fuselage, and a device for implementing this process. A fuselage includes a primary structure, formed, in particular, of transverse frames and of longitudinal stringers, of an external skin supported by the primary structure, and also of a floor fixed to the primary structure. At the time of fabrication of the fuselage at a production site, numerous parts of various types are fixed to the primary structure in order to reinforce it, such as, for example, a linking plate and a backing plate, fixed to one another at the juncture between two coplanar frames and clasping said two frames in order to couple them to one another. At present, the parts to be fixed are fabricated by various entities outside the production site and are then conveyed to the latter where they are put away in the warehouse of the production site. Prior to the fixing of the part to the fuselage by screwing or riveting, the operators have to go and look for the parts in the warehouse in order to transport them into the fuselage to a position where they have to be fixed, they have to set these parts by means of liquid or pasty setting, necessitating a significant drying-time, in order to take into account the defects of contact between the primary structure and the part, said defects being due to the clearances (less than one millimeter) inherent in the jointing of elements of large dimensions. These measures slow down the rate of production of the fuselages. One solution to this problem would be to fabricate the parts directly on the fuselage at the place where they have to be fixed. From document EP 2 537 642 a device is known for printing of parts in 3D, but this device is arranged in a closed enclosure specifically dedicated to the printing, and only enables a part to be fabricated in accordance with a predetermined template, the part fabricated in this way (necessitating a machining phase in order to extract it from its support plate) still having to be conveyed to the production site and then set.

"Back then, this is years ago," "I couldn't afford secrets." "I just had chores." "As a child, growing up, we had been rich." "And then..." "well... we weren't." "And like most people during the Depression," "I now lived each day as it came, no longer expecting anything." "Waiting -- for nothing." "And then..." "Hello?" "Yes." "What?" "Sh-sh!" "Be quiet." "Sinus?" "Somebody die?" "No." "No one Mom..." "Good Morning Miss Dayse." "I wasn't the first relative his Mother called that day." "Maybe not even the tenth." "But I was around." "His Mother said he needed someone to take his mind off his work." "Why she thought I could do that," "I had no idea." "I suppose he's related to half of everybody up here." "We're fifth -- or sixth cousins." "Depends on how you count..." "Cigarette?" "No." "No, I don't." "I figured I'd spend the afternoon there, and after having thoroughly bored him to death, go back to my quiet life." "taking care of my act" "But was not what happened" "He's not been feeling well." "Sinuses." "Seems to happen every time, the second he comes home." "Mr. President?" "Daisy." "What a rare treat." "I hope my mother didn't force this on you." "She said everyone else was away." "Did she?" "She shouldn't have said that." "How nice to see you." "How long has it been?" "Oh, years." "The Dows' wedding, sir." "In Rhinebeck?" "Oh, were you there?" "Where would you like me to sit?" "There's tea..." "I think there's still tea." "Will you..?" "I can do this because my mother's not here." "She doesn't believe in sinus medicine..." "Do you collect stamps," "Daisy?" "I - don't." "Come and look at these..." "I suppose you've met pretty much everyone of these..." "Not every one." "Not yet." "Excuse me, I should have knocked." "I actually wrote this?" "My cross, Daisy, is that I am too nice." "But -- we need the Senator's vote." "Don't we?" "Why can't politicians just be honest?" "My cousin." "Those are from Africa." "They say that's the highest waterfall in the world." "Would you like me to go?" "No." "Please." "I wouldn't." "This one's pretty." "I'd like to go there." "Where is that?" "Well." "To be honest," "I'd like to go almost anywhere." "In Europe there would certainly be another war, one we would be dragged into, whether we liked it or not." "Here at home, the country is still in a depression people out of work" "Hungry needing help" "the President spent an awful lot of time that spring in Hyde Park On Hudson." "Fellows, one of you please tell Mother -- that this is radio?" "He said " "I helped him forget --." " 'the weight of world'." "thirty seconds look at me..." "I think that means you, Mother." "His Mother said he'd run the whole country from here if he could." "But he couldn't." "Not with how things were " "Everyone knew someone who couldn't find a job the first duty of government" "Everyone scared." "is to protect the economic welfare of all the people and in all groups..." "I said... if private enterprises does not provide jobs this spring government will take up the flag we have all learned the lesson that government cannot afford to wait until it is lost the power to act." "therefore I've sent a message of reaching a prop to the congress" "And everyone looking to him." "They all wanted something from him." "The local labor union, the Hyde Park Chamber of Commerce, the German-American Friendship Band." "And all he wanted -- was to relax." "Each time he came home, he'd telephone and ask:" "Daisy where would you like to go today?" "And I would always answer -- 'anywhere.'" "His wife, he said, didn't like to take drives." "I learned the names of birds and trees" "I'd seen my whole life." "We drove along country roads, up hills, through woods, through fields." "we drove down roads I never knew the existence." "Roads later..." "I couldn't find by my own." "He'd had the car built so it could be driven with just the hands." "In some ways it's smoother than the regular car" "Do you like to drive?" "I believe I helped him to forget the world" "As we just run away" "And then, one day..." "Where's the police car going?" "Oh, they don't follow all the time." "Sometimes they have to go and catch a crook or something," "I suppose." "We've not been here before?" "No." "I've been saving this." "I like this song." "I'm sorry." "I'm sorry." "I'm" "I'm the one who should apologize..." "I knew, that we were now -- not just fifth cousins " "but very good friends." "As soon as I can get away." "time passed." "Time measured now in Franklin's visits to hyde park." "Who was that?" "The President wishes to see me." "And he's the President." "He wishes to show me a new stamp." "Where are we going?" "I don't know." "I had it built." "It's where I'll retire." "I'll write those detective books" "I'm always talking about." "go, take a look... go on..." "There's no better place to smell it" "It's heaven!" "I have been thinking, Daisy..." "What?" "What have you been thinking?" "I'd like to--." "To share with you " "this." "When I go away..." "You know I have to go ..." "away." "Should you ever miss me...?" "Do you ever miss me?" "I always do." "Always." "A place to come." "And be alone." "And miss me..." "Oh!" "I am sorry!" "Sorry." "That's all right!" "By now everyone was used to me." "I was the cousin who's always visiting." "No one ever even asked me why that was." "Has he read this?" "I believe he has." ""If one could choose, from all possible British personalities, the two who might make the best impression upon Americans " "King George and Queen Elizabeth would not even make the short list."" "How dare they talk about Royalty like this!" "No King of England had ever visited America before." "But now he was coming -- to Hyde Park on Hudson." "and the only quiet place left to work was outside" "What are those for?" "He has a headache." "You do?" "His sinuses again." "Happens this time every year." "I know that." "You didn't say anything about a headache." "He's not going to trouble you with everything, Missy." "You have enough on your plate." "What does that mean?" "It means -- you take very good care of me." "It means that you do too." "Mrs Roosevelt, we appear not to have enough plates." "What?" "We don't have enough plates." "Someone miscounted." "You tell me this now?" "Mrs Astor has called again." "Franklin warned us," "Mrs Astor will have plates." "We'll borrow hers." "today, stayoutof Mother'sway ." "On second thought -- we shall call for cook." "Mrs Astor is so rich, she doesn't know what she has." "Franklin's wife, Eleanor." "I'm just doing what I'm told." "So much for your little secret..." " Good morning, Mother." " Good Morning." "Eleanor." "We are not going to serve the King of England - a cocktail!" "Your Mother has now told me for the tenth time -- not to call her Royal Highness -- Elizabeth." "She's told me that too." "I mean, please -- what century is this?" "Daisy?" "Daisy?" "Oh yes." "She told me the same thing." "I told her who did she think I was?" "I think she knows." "Daisy?" "Hello!" "You're just staring." "I'm not." "I wasn't." "What do you want?" "Eleanor's just brought out fresh coffee." "She was asking if you'd like any." "She's staring again." "I'm not." "Missy, Leave her alone." "My husband lives for the adoring eyes of young women." "We know this." "Let's change the subject, shall we?" "Don't tell me you're embarrassed." "That day," "I would like to see." "I didn't say I was embarrassed." "Why do we care what a 'king' or 'queen' thinks about us?" "Real rosewood." "Still got the smell." "Is that why it cost so much?" "Hick called." "For this morning's Royal visit she'd been ordered to produce five thousand children overnight." "What?" "Why?" "As buffers for holding back the crowds." "No." "The Girl Scouts refused outright--." "Good for them." "They said their girls had taken an awful beating in DC!" "So she finally got some Boy Scouts!" "But when they were pushed, they pushed back!" "Started something like ten fist fights!" "When she finally got back to her office, she kicked off her shoes, opened her window and shouted out:" "'God damn the King and Queen!"" "we'll maybe saying the same thing tomorrow!" "'Hick' was short for Lorena Hickock." "One of those friends of Eleanor's Franklin called " ""she men."" "People said their marriage was troubled and unhappy." "That they lived mostly separate lives." "But I never saw that." "That's now how they seemed when they were together." "We ended it up" "And stated our last hope for refuge." "are no better than us." "They're just people." "I read that in your column," "Eleanor." "Are you all right?" "You look in pain." " He has a sinus infection." " He gets them -- this time of year." "Oh does he?" "I didn't know that." "I took an aspirin." "They just left Beacon." "Good!" "won't be too long." "Hick says I should get a month of columns out of this weekend." "Hick says this King hates his brother." "There's a column right there." "His brother's met with Hitler." "That's good." "There's another column..." "And this is the family we're having to our home for the weekend." "you don't even live here." "I am staying the night." "Besides, I told your mother." "I thought the brother gave up being king so he could marry the woman he loved." "Daisy, have you ever met a man who would do that?" "Hick says she thinks the brother might be positioning himself to be the savior of the monarchy, once England has been defeated and the fascists have taken over." "Of course." "He's young, Eleanor" "So is she." "They're both young." "Now let's just give them a break." "Can we?" "Andallthewild,thekingandqueen were getting close." "Should we stop and meet some people." "Wouldn't that be a good idea?" "But..." "We've just left..." "We're almost there." "I don't think there are any more towns until..." "It's just a country road now." "Still..." "He wants a cigarette." "We don't want to be e-e-e-arly." "No." "No we don't." "And I'd like to meet some Americans." "Doesn't he want to meet you?" "He's busy." "I know how important this is." "You're not going to let the side down." "Don't worry." "That is what I've been telling myself too." "You started to talk about the weekend's itinerary." "You will be staying in the Roosevelt house." "In fact, it is the President's mother's house, and she will officially be your hostess." "Where is the President's house?" "This is where he lives." "When he's not in Washington." "With his m-m-mother?" "He doesn't have a house?" "He has a room." "And his wife?" "She lives in another house." "Hers." "And he doesn't--?" "Which she shares with other -- women." "Who make furniture." "I'm sorry?" "Furniture." "They make it." "Build it." "They're couples." "They're the sort who like each other." "The Ambassador's wife, after having visited Hyde Park..." "Why do they call it that?" " What?" " Hyde Park, is in London." "It's confusing to me." "I don't know." "Our Ambassador's wife wrote - and I think you need to hear this." "She wrote" ""It is a dismal house, extremely badly run, and most uncomfortable."" "## I don't want to set the world on fire" "## I just want to start a flame in your heart" "## In my heart..." "Half of his cabinet had been against the visit." "The country, they said, was in no position to take sides in another European War." "So Franklin invited them here where, out of the spotlight, we could all relax and just be ourselves." "## I've lost all ambition for worldly acclaim" "## I just want to be the one you love" "## And with your admission that you feel the same" "## I'll have reached the goal I'm dreaming of" "## Believe me" "## I don't want to set the world on fire" "## I just want to start a flame in your heart" "Looking back," "I now see how important this day was, to them, to us, to the world." "And of course -- as it turned out," "to me." "Oh, what lovely ships." "My son built them when he was a boy." "How very clever." "Wasn't that clever?" "T-t-terribly clever." "He also did the birds... as a boy." "Until the taxidermy smells made him ill." "He'll tell you about it." "I shall look forward to that." "## I don't want to set the world on fire" "## I just want to start a flame in your heart" "Come in." "Please," "I can't tell you, how I am awfully of this." "My Mother, hasn't spoken of nothing else for months.." "Hei, Daisy!" "Mr. Cameron's with the embassy -- this is Daisy." "Hello!" "How do you do?" "How do you do?" "That day, the President, sent me upstairs on a mission... to spy... behind enemies lines." "Charming." "Look at that view." "You must tell me about everything." "That's -- the field." "We have fields just like that." "Those hills -- lead down to the river." "So that's where they go." "What are you doing?" "I came to see if I could be any help." "Do you mind if I call you Elizabeth?" "No." "No." "So these are the beds -- your friend made?" "." "Those are them." "Not bad." "Not bad." "Is my wife behaving herself?" "Yes!" "Has my mother calmed down?" "She's fine!" "It's like a madhouse." "Don't worry." "All quiet on the upstairs front." "He's definitely younger than I'd imagined." "For a King, you know...." "Is he..." "And they both seem nervous." "That surprised me." "Without some help from us, Daisy -- there soon might not be an England -- to be King of." "So I'd be nervous too." "Anyway, that's why they're here." "Damn it." "Let me do it." "Let me do it." "They seem very nice people." "Smell like Martini." "Later tonight, after the dinner and all that is over, what do you say, you and I get out of here?" "Go someplace quiet." "I think I'll need that." "Well -- I think I'm free." "It's going to be a big, big success." "Oh -- it's you." "We share a bath." "So I was t-t-told." "So we don't have to go through the..." "Yes." "What were you looking at?" "These prints." "I just told the President's mother how humorous I found them." "What are they of--?" "British soldiers." "The 1812 War." "Cartoons actually." "Mocking them." "Us." "They put you in a room with--?" "The mother tried to apologize." "I told her I found them funny." "She said she tried to remove them, but her son insisted." "Why would he do that?" "What was he trying to say?" "I don't know." "I don't know." "He knows this is important." "He knows why we're here." "May I have a drink too?" "How many have you had?" "The mother just left." "Cheers." "She apologized for everything." "For Eleanor m-m-mostly." "And for the hot dogs." "Hot dogs?" "What are you talking about, Bertie?" "It appears that at the picnic tomorrow--." "There's a picnic tomorrow?" "In our honour." "You hate picnics." "At the picnic, the President's wife has organized that hot dogs be served as our main dish." "I gather she's even publicized this in the column she writes." "Are they trying to make fun of us?" "I d-d-don't kn-kn-know." "What do you think?" "You're not going to tell Mother, are you, Mary?" "Not a soul, sir." "Mary, we all knew, was one of Mother's spies." "Mother had spies them too." "These are revolting." "They make our seamen look like monkeys." "I can't believe he thought these would make you laugh, Bertie." "I 'laughed'." "They're trying to make us seem -- common." "Your brother would never have stood for this." "I'm sorry, but he wouldn't." "I th-th-think if we j-j-just ignore the-the-these--." "Please, stop stuttering!" "I'm sorry." "I'm very sorry." "I didn't mean it, Bertie." "I think I have a headache." "My face feels hot." "Feel sorry." "I am not my brother." "Thank God for that." "And you are not the D-d-duchess of Windsor." "You are better than that." "I just hate to see you..." "See me...?" "Laughed at." "Mother, who had a sixth sense for sniffing out alcohol, was on the warpath." "Mother's father had been a nasty drunk." "Is he coming down?" "What is that doing in here?" "Leave it, Mother." "I thought we had agreed." "That's not true." "I'm not going to serve the King and Queen of England " "Dammit, I said -- leave it!" "close the door." "Daisy." "Why are you shouting?" "I am not shouting!" "Close the door, Daisy!" "Should I stay?" "Just close it." "He's brought out the drinks tray," "Eleanor." "Franklin, you promised." "As I said to Mother, that's not true." "Maybe after dinner!" "Don't shout, Mother." "We have guests." "I know we have guests!" "And I know who they are!" "And my son is not going to serve them cocktails!" "They're my guests!" "It's my house!" "You're the one who wants us to live here." "Eleanor, please, don't-- remember that." "Give me the tray." "Isn't it true?" "No." "Yes." "I'm the President!" "Oh!" "Just stop this!" "Stop this." "You behave like a child!" "I have the programme for tomorrow's 'event.'" "This is for the hot dog picnic?" "There will be entertainment as well." "Perhaps I should be surprised." "Indians." "No." ""Ish-Ti-Opi."" "What?" "He's called here "The Indian Baritone."" "So he's going to sing." "There's "Princess Te Ata."" "She is going to show us "The Indian Corn Ceremony."" "Oh god." ""Accompanied by Kurkus Pahitu on the Tom-Tom."" "There's our incentive not to be hungover." "The 'tom-tom.'" "'Hot dogs.'" "'Cartoons of British naval officers as monkeys.'" "Come in." "The President is waiting for you in his study, your Majesty." "He said it was time for -- 'children's hour.'" "Drinks." "And the Queen?" "She's been allowed more time to relax." "Here we go..." "Good luck!" "Sir, my Mother does not approve of cocktails." "And thinks you might rather have a cup of tea." "M-m-my m-m-mother would have said the s-s-s-same thing." "Actually I-I-I-I-I prefer a-a-a-a cocktail." "A man after my own heart..." "So she said:" "'I'm so pleased to meet you, Mr. President," "I've only met three Americans." "Joe Kennedy," "J.P. Morgan, and Fred Astaire.'" "'Thank God,' I said, 'you met Mr. Astaire, or what would you think of the rest of us?" "'" "Good evening." "Good evening." "Mrs. R-r-r Roosevelt" "Mrs. R-r-r-r-r-ro-ro..." "I'd love to, your majesty." "We could have sold tickets to this dinner, and made ourselves a pile of money." "The moon was coming up there was a warm..." "summer breeze" "It was... just... her" "A perfect summer night!" "To His Majesty, the King." "Inside..." "Everyone was very impressed behavior!" "To His Majesty, the King." "And to Her Majesty, the Queen!" "Actually, normally, we wouldn't toast the Queen." "The tray... was of Mrs.Astor" "24 plates collapsed fornoreason." "just before the soup." "What happened?" "I don't know." "No one touched it." "I su-su-suppose an angel just passed - a ve-ve-ry clumsy one." "but some people had other explanation..." "It's the full moon." "Daisy?" "Oh hello, Dick." "You think it's full tonight?" "What?" "Oh -- yes." "That moon certainly is full." "She says I'm right!" "Oh, I don't know for sure--." "I could be wrong." "I just...." "Such an important night." "Is it?" "I don't know." "What's one king more or less?" "He still has to put his pants on one leg at a time." "Did you curtsey for the Queen, Daisy?" "I certainly did!" "And I think I did it right." "I didn't fall down!" "How come you're not inside there, Daisy?" "I'm glad to see you working." "It's just for the one night..." "Well it's something..." "Can I take some home for my dog?" "He doesn't have a dog." "Touch me there again, you'll be wearing it and not eating it..." "Nu-nu-number 2!" "Shoot!" "Those damn horses." "It's not the horses' fault--." "I know." "I know." "You like them." "I've been looking for you." "Do you need a handkerchief?" "Come here." "We saw you out here--." "We?" "Franklin's asked me to tell you that you could go home." "He thinks he's going to be occupied with the King all evening now." "Of course he will..." "Noonelosttogoto bedthatnight." "Hewishedto spendtime with the king, on his own." "Let's go to my study." "Will be quiet out there." "Unless you need to--." "No." "No." "Would you mind pushing?" "Her Majesty has gone to bed?" "She has." "And -- your wife?" "Who knows?" "I'm sure." "Would you my closing the door." "Cheers." "Cheers." "Do you collect stamps?" "I did." "I have." "I understand you are a serious stamp collector." "Perhaps, you would show me some of your stamps." "You can't be interested." "But I am --." "Do not -- protest." "When I was a young man -- before my marriage of course " "I found that showing one's stamps was a very helpful way to get a young woman's attention." "Was it." "But I suppose if your father's the king..." "Who needs stamps?" "The Queen is certainly a lovely woman." "As is the first lady." "She's a -- strong -- person" "Some days you don't feel like getting out of bed " "but then these women, they won't let you do that, will they?" "No." "What do you do -- to be alone?" "You need to give them a reason not to bother you." "You can figure things out in the quiet of your own mind." "I open up my stamp books and everyone knows not to bother me." "You were wonderful tonight, young man." "What do you mean?" "Just what I said." "You were graceful." "You were confident." "You're going to be a very fine king." "I don't know what to say." "Your father would be very proud." "I'm not so certain about that." "If I were your father," "I'd be proud." "The Queen -- she's..." "She worries so much." "It's been hard for her." "Women worry." "I just stop listening to her sometimes." "Forget I said that." "Forgotten." "I've been asked to say things..." "Such a war as we now co-cocontemplate --." "The carnage," "Think at S-S-S-Spain." "Ch-children -- b-bbombed." "Tha-tha-that's what we can expect." "It will b-b-be horrific." "And yet we know some of your countrymen wi-wi-wi-sh my country ii- i-i-ill..." "And w-w-want us to fail." "And want me to fail wi-th-thth you..." "This god damn st-st-stutter..." "What stutter?" "This god damn polio." "Sometimes I think -- they deserve better than me." "My -- 'subjects.'" "I'm sorry." "I don't know why-why" "I'm saying this to you." "I'm s-s-supposed to be trying to convince you to help us." "Let me confess something to you, now." "As you have been so honest-- with me." "No one -- ever mentions the fact that I can't use my legs." "It's never referred to." "Not by anyone." "I used to think it was because they were embarrassed about it." "But now I think it's because is not what they want to see." "Of course you and I" "We think they see everything that we are." "All our flaws." "Or transgressions." "Or failures." "But that is not what they're looking to find when they look to us." "And God help us if that ever changes." "Do you imagine the disappointment... when they find out what we really are." "Thank you." "They didn't want me as their King." "I didn't know they voted for that in England." "I'm thinking -- another drink?" "Right!" "Suddenly only one can sleep that night" "Was it the moon?" "How a longed fan" "I beg your pardon..." "Sir." "I mean, Your Highness." "Your Majesty..." "Good night." "You're still awake?" "Mmmmmmm." "I think I'll go to sleep." "It's late." "Why are you smiling?" "Are you drunk?" "No." "He's a very funny man." "Has some wonderful jokes." "Like what?" "I couldn't tell you." "They're not meant for women." "They sound very 'funny.'" "He liked my stories too." "What stories?" "I-I-I told him about the coronation." "About how they p-p-put the crown wrong way around." "And the stepping on my robe so I couldn't move." "You shouldn't have told him that." "We don't make fun of ourselves." "That's not true." "Not here." "Of course he liked those stories, they make us look like fools." "They make us look like people!" "Don't be naive, Bertie." "He made fun of himself too." "He said at the picnic tomorrow" "Oh god that picnic." "He said that the Indians -- they were Eleanor's ideas." ""One of my-my-my wife's crazy ideas."" "His Mother is furious about it." "Franklin's just trying to keep it short." "He talks about his wife like that to you?" "I hope you didn't talk about me to him." "I didn't." "I wouldn't do that." "We didn't talk about you." "I asked him -- without mentioning you " "about these hot dogs?" "What's that about?" "You want to know what he said?" "He said he doesn't get the fuss." "They're just a good thing to eat at a picnic." "There's no 'meaning.'" "Nothing more." "You didn't say I was concerned?" "No." "I'm not sure I believe you--." "That's not fair." "Three different women tonight asked me if I thought there could ever be an American queen." "If we'd ever 'allow' that." "That was rude." "Give me a cigarette?" "I have smoked all of mine." "That won't help you sleep." "I know." "Thank you." "Give me lighter?" "Light, of course!" "I never wanted this life." "I know." "It's hard." "I'll be fine." "If there's a war -- and we know there will be " "he believes America could be persuaded to help." "Did you see some of the people here tonight?" "Hear their names?" "They're from Italy." "Germany." "They're Irish." " Their ancestors-- - they're Jews." "They hate us, Bertie!" "They want to see us fall on our face!" "They want to laugh at us!" "I think you're wrong." "I th-th- think we just need to be a little more confident." "I'm not sure I can even sleep." "Finally, he patted me on the knee and said," "'young ma-ma-man, it's time for you to go to bed."" "Like a father, I suppose." "He's very happy that I am king." "Good Night." "## If I didn't care more than words can say" "## If I didn't care would I feel this way?" "## If this isn't love then why do I thrill?" "## And what makes my head go 'round and 'round" "## While my heart stands still?" "## If I didn't care would it be the same?" "## Would my ev'ry prayer begin and end with just your name?" "## And would I be sure t hat this is love beyond compare?" "## Would all this be true if I didn't care for you?" "If ever I missed him, there was a place he'd built for me to come," "and be alone, and miss him." "What the hell are you doing up here?" "Tommy?" "What the hell are you doing here?" "You shouldn't be up here now." "Why?" "Why not?" "Can you get that out of my face, please?" "President can't be disturbed right now, Daisy." "Daisy!" "How nice to see you up here." "Do you want to see the President?" "Come back." "Come back!" "Daisy!" "Daisy!" "Daisy!" "Here." "No." "Get out of here." "Listen to me, Daisy." "He wants to talk to you." "He's going home." "He's headed home." "I want you to listen to me." "very very carefully." "Understand?" "Understand?" "Look at me." "Look at me, Daisy." "Understand?" "I know you are -- intimate." "I've known since the day it happened." "What?" "Those things he said?" "He meant them." "I know that." "That hurt." "Cigarette?" "I need one." "But I accepted." "Like you will." "I am a part of his life, and I accept that you are too." "I don't accept you." "What about Dorothy Schiff?" "Do you accept her?" "Why do you think she has built that place next to Top Cottage?" "He asked her to build a cottage, so they could live close together when he retired, while he wrote those goddamn detective books he's always talking about writing." "I read the letter." "When was that?" "This year." "It wasn't Eleanor who 'abandoned' him." "She caught him too." "With you?" "No." "This was -- long ago." "Years and years ago." "Maybe you've met her." "Mrs. Rutherford." "I..." "I misunderstood." "I wonder..." "I wanna us... realistic." "I don't think I can ... 'share'" "Oh I think you can." "You can." "You decide." "You won't go to bed." "He's waiting for you." "Missy and my Mother both severely criticized me for not having invited you to the dinner tonight." "I want to apologize." "I think I showed you these when you first came to visit me, Daisy." "But you probably don't remember." "I remember." "Aren't they beautiful?" "Can you see from over there?" "The highest waterfall in the world." "That's on this stamp." "I really don't think you can see from way over there, Daisy." "I really don't." "And that -- would be terrible." "Not to." "How do you see me?" "What?" "Am I -- to you -- just stupid?" "No, Daisy." "But I can understand how you can feel that way." "Am I " "Like... a whore?" "No, you are not 'like a whore.'" "Now would you come over and sit by me." "No, you're not getting off that easy, you son of a bitch!" "But that's not what I said." "Instead:" "No." "I need to go." "I'd say I'm sorry -- but that wouldn't do any good right now, would it?" "Someone's coming out." "Which one is she?" "The one you think looks like a governess." "I tought she was the governess." "I understand that's a very common thing -- men and their children's governesses." "She's not the governess." "But she's obviously his mistress." "She dresses like a--." "She's not the governess, Bertie." "Men find -- some men find" "I think because they're around children, there's something quite attractive about" "Why do you keep talking about governesses?" "Is there something you want to tell me?" "No." "Nothing." "Why?" "Look over there." "The secretary?" "I hadn't seen her before." "And she's his mistress too." "According to Cameron." " We don't need Cameron to--." " Cameron says there's another one." "Another--?" "Who's married." "But she's built a cottage by his?" "Or something." "Another mistress?" "Good thing we changed our minds about bringing Lilibet with us." "You changed your mind." "I never wanted to bring Lilibet to America." "Only be-be-because you don't like Americans." "I like Americans." "That's not fair." "I don't like a lot of Americans." "I like some." "Bertie, are you going to eat a hot dog?" "What?" "At the picnic." "Tomorrow." "Today." "I mean, isn't it like having say the PM over and serving him bangers and mash?" "He probably would like--." "To a guest!" "If we did that he'd know we were trying to tell him something." "He'd understand." "What would he understand?" "How we felt about him." "The PM knows how we feel about him." "We like him." "As if that matters." "You know what I mean." "I wish I did." "Bertie, I don't think your brother would eat a hot dog." "How would you know that?" "Because he'd know what was meant!" "It doesn't mean anything!" "The walls, sir." "They are quite thin." " We know." " One can hear--." "Everyone in this house is already awake." "But to answer your question, Elizabeth," "I am going to eat a hot dog, no five hot dogs, ten!" "I'm going to shove them into my mouth, stick two up my nostrils, two more in my ears, then walk around so people can take pictures of the King of England with hot dogs hanging out of his orifices!" "Don't ever compare me to my brother again." "Sir." "It's the President." "Has she gone?" "What do you think she's going to do?" "I don't think she'll cause you any trouble." "If that's what you're asking." "Is that what you're asking?" "They'll see us." "Hello!" "And good morning!" " Wave." " I am." "Hello!" "Hello!" "Lovely morning, isn't it?" "Sleep well?" "!" "Oh yes." "Yes, we did." "Didn't we?" "We did!" "Good!" "Me too!" "I thought I might have a swim..." "Come along?" "gosh... a swim." "Daisy is that you?" "Let me help." "You're up early." "I just woke up." "And so, the day of the picnic began." "And everyone pretended, as usual... not to notice anything." "They feeding you all right out here?" "Boys." "Throwing you the odd bone?" "We're eatin' like kings." "Mr. President." "You have king to thank for that." "I made them all agree -- no pictures in our bathing suits." "Though you don't look so bad." "Maybe you should get your picture taken like that..." "And get the women's vote." "But that's right -- you don't vote for king." "you two counfy like that?" "Yes, thank you." "Here we are." "I'm not driving with him again." "Wave..." "Wave, wave..." "She's here." "Good for her." "What are you doing?" "I'm ... so pleased you came." "I promised my Aunt." "How do you do?" "How do you do." "Mrs. Langdorf" "So nice to meet you." "Tommy, looks who's here." "Daisy, would you come with me?" "Tommy, she has every right to be here." "He wants her sitting with him." "I'm not doing that." "Who wants you sitting with him?" "The President, ma'am." "Daisy..." "Daisy, please." "Where are your manners?" "Let's sit up with the President." "Just Daisy, thank you ma'am." "Please." "Daisy," "What were you doing way over there," "The special guests are here on the porch." "You should be here." "Please sit down, Daisy." "Please, Daisy." "How much more of this is there?" "Thank you, Indian Baritone!" "Thank you so much." "He wasn't finished." "Oh." "I thought he was." "Thank you, thank you." "Let's all say thank you, to Ish-Ti-Opi in Cherokee which is tokapi" "Tokapi" "Come all say it again, boys and girls come on..." "Let's enjoy it, say Tokapi" "Tokapi." "Thank you, thank you so much." "at last... after Eleanor's Indians... the event we're all secretly waiting for..." "Your Majesty..." "Would you like -- a hot dog?" "Do you take mustard?" "I take ... whatever you think I should take with my hot dog." "Allow us then to put a bit of mustard on for you." "Daisy, would you show how we put the mustard." "You are too kind." "Why are they applauding?" "It's all right!" "It's fine!" "What's this about?" "And like that -- we felt America and England were back on the road to being very good friends." "At least," "I'm told that's how some people took it." "It made me wonder -- maybe the hot dogs hadn't been Eleanor's idea after all." "When he left for England later that day, the King sent back a telegram, in which he wrote that our two nations had now 'forged' -- and these are his words:" "a special relationship." "It's good!" "It's all fine!" "I'll have another!" "The next day, he sent a car." "But I said I was too ill to take a drive." "I was ill the next day." "And the next." "And the next day after that." "A week after the Royals' visit to Hyde Park, thePresidentcameinperson to my house." "Good morning." "I had been waiting." "He drove us by the plumbing shop where his mother had returned the toilet seat she had ordered for the Royal Visit, without paying for it." "He tried to make me laugh." "And he was good at that." "He was after all a politician." "Mother wants to pay him now." "But he says it's really been good for business." "He hoped I would forgive him." "But I was damned if I was going to tell him that I already had." "Occasionally now," "Missy would come and fetch me when she felt --." "I think he could use -- your company tonight." "Let him wait." "When we play cards..." "MissyandIare partners... wenowshareeverything!" "I learned, as we got to know each other better, of Missy's bouts with her 'blackness.'" "And of her 'dark days.'" "When she fell terribly ill." "He paid for everything." "He even changed his will -- giving her half -- should she outlive him." "But to the surprise of nearly everyone -- he did not visit her once in the hospital." "I asked him why." "It's a terrible fault of mine, he said." "I find it too painful to be around illness." "I grew close not only to Missy but to all of Franklin's boys." "They seemed to accept me, no questions asked." "And no more promised were made so none could be broken." "Ayearpass..." "Andthen,another... andanother..." "Iwatchhimgrowtired, and fail and ill" "Hetriedthehighbest of everyone..." "Heknewhowtodothat." "foreveryone,butme..." "Mr. President." "Ok boys, Take it away!" "Everyone still looking to him." "Still seeing it ever was." "Theywantto see." "Inthetime..." "Notsoverylongago..." "When the world still allowed themselves secrets..." "FranklinRoosevelt wasmine."

Rotary dial telephones encode dialed digits by repetitively breaking the line current in a subscriber's loop, the number of breaks corresponding to the dialed digit. Dial pulse receivers and repeaters have from the early days of telephony utilized electromagnetic sensing of the dial pulses, by which a solenoid in a relay causes switch contacts to repetitively close, or in a stepping switch, contacts are caused to step along a row or column of switches. While the repetitive line current breaking function theoretically provides square wave current pulses carried by the telephone line, in practice the form of the dial pulse current is usually far from perfect. Variations from the ideal square wave are usually caused by lines inductance, line leakage, leading and trailing edge ringing, cross talk, gliches, etc. While electromagnetic dial pulse receivers have been found to be somewhat tolerant of most of the imperfections in the waveform, more modern sensitive solid state dial pulse receivers have not had similar tolerance. Special circuitry has been incorporated into some solid state receivers for debouncing leading edge ringing waveforms, etc. However it has been difficult to reliably detect dial pulses when there are gross distortions of the dial pulse current waveform. The present invention is directed to a reliable solid state circuit for dial pulse detection when the current pulses are grossly distorted.

Enzymatic treatment of whey proteins in cow's milk results in differential inhibition of IgE-mediated mast cell activation compared to T-cell activation. Cow's milk (CM) hydrolysates are frequently used as milk substitutes for children with CM allergy. In hydrolysates, allergenic epitopes within CM proteins are diminished by enzymatic treatment. The aim of this study was to examine the allergenic and immunogenic properties of whey proteins during hydrolysis. During hydrolysis, samples were obtained at 0, 10, 15, 30, 45, 60, 75 and 90 min. Degradation was checked by HPLC and SDS-PAGE. Allergenic potential was analyzed by IgE crosslinking capacity of human Fcε receptor type 1-transduced rat basophilic leukemia cells sensitized with serum of CM-allergic patients. Whey-sensitized C3H/HeOuJ mice were ear challenged intracutaneously with the hydrolysates. Immunogenicity was tested using whey-specific human T-cell clones and T-cell lines at the level of proliferation and release of IL-4, IL-10, IL-13 and IFN-γ. After 15 min of hydrolysis, the majority of the proteins were degraded. Hydrolysis for 15 min resulted in 92% inhibition of mast cell degranulation and in 82% reduction of ear swelling in the mouse model. In contrast, T-cell-stimulatory capacity was less affected by hydrolysis: reduction of human T-cell proliferation was only 9%. This was further reduced to 57 and 74% after 30 and 45 min of hydrolysis, respectively. Cytokine production followed the pattern of T-cell proliferation. Via differential analysis of allergenic versus immunogenic properties of the time kinetics of hydrolysis of whey proteins, we have demonstrated specific hydrolysis conditions with reduced IgE-crosslinking responses but retained T-cell activating properties. This approach might be useful in better defining CM hydrolysates.

Intrahepatic abscess due to gallbladder perforation. Perforation of the gallbladder with cholecystohepatic communication is a rare cause of liver abscess. We report four cases of this condition and describe the imaging procedures related to its diagnosis and treatment. The medical and x-ray files of 39 patients with percutaneous drainage of liver abscesses were retrospectively reviewed. Four patients with hepatic abscess due to gallbladder perforation were identified. The patients presented with clinical features suggestive of cholecystitis. Sonography in four patients showed a hypoechoic lesion in the liver adjacent to the gallbladder. CT in three patients showed a hypodense area in the liver, corresponding to the sonographic findings. Percutaneous abscess drainage, followed by an abscessogram, was performed in all patients. Contrast material injected through the drainage catheter filled the gallbladder directly from the abscess cavity. Two patients subsequently underwent cholecystectomy, confirming perforation of the gallbladder fundus. In both cases the gallbladder was noted to be embedded in the liver and covered by adhesions. Perforation of the gallbladder is a rare cause of pyogenic liver abscess. We suggest, however, based on our two patients who underwent surgery, and several cases reported in the literature, that this condition may be more common when the gallbladder is partially or totally intrahepatic.

U.S. Pat. No. 4,558,181 describes a device which monitors several selected conditions at a local area. If the selected conditions exceed predetermined limits or deviate from normal in some other manner, the device places a telephone call to one of several preselected telephone numbers and waits for the preselected telephone to be answered. If an answer is received, the device gives a speech message describing its location and the alarm condition detected. If the preselected telephone is not answered, the device calls another preselected telephone number in its list of telephone numbers in an attempt to reach someone and report the alarm condition. The device is exceptionally versatile in the types of conditions which can be monitored and in the means of providing information to persons designated when alarm conditions exist. The device had only a single mode of communication; however, this is through synthetic speech. The Invention The present invention contemplates a portable monitoring device for monitoring conditions at a selected location and communicating an alarm when conditions deviate from preselected ranges. The present invention communicates its alarm over the existing telephone network in either a synthesized speech format or in a digital data representation format. In accordance with one aspect of the present invention, there is provided a portable self-contained device for monitoring a selected local area having a standard telephone terminal connected to the commercial telephone network for the occurrences of any of a plurality of conditions adjacent the local area. These conditions can be high or low temperature, power interruption, operation of a smoke, fire or burgular alarm, existence of a high water level, entrance through a restricted area or virtually any other electrically monitorable condition. When one or more of the selected conditions deviate from preset ranges, an alarm signal is generated and the system of the present invention communicates such alarm signal to either a remote data reception terminal or a remote human being through transmission of an alarm signal in digital code or synthetic speech. In accordance with the general scheme of the present invention, there is provided an electronic circuit and several sensors at the local area to be monitored. The sensors generate signals when the conditions being monitored vary from a preselected range or exceed certain limits. Analog processing circuits condition the signals from the sensors and supply appropriate signals to a microprocessor through an analog to digital converter. The microprocessor has associated with it random access memory (RAM) into which telephone numbers, identification codes and other data required for the operation of the circuit is loaded by means of a key pad. When the output of one of the sensors indicates that a preselected limit has been exceeded, an alarm condition is established and an alarm signal is generated. The alarm signal causes the circuit to generate telephone dialing signals initiating a telephone call on a standard telephone circuit interconnection. The system first attempts to reach the telephone number stored in its first preselected telephone number memory location. If an answer occurs at this location, the circuit looks for a digital acknowledgement signal or "handshake" informing the circuit that a digital terminal is connected at the number recalled. Once this handshake is received, the microprocessor applies digital signals to a modem which communicates with the terminal at the number called such that a code identifying the location being monitored and a message describing the alarm condition are sent to the terminal. If an answer from the first destination number is not received, the circuit continues to try this number until an answer is received or a predetermined period of time expires. After the expiration of this period of time, the circuit calls secondary preselected telephone numbers stored in its memory. A "speech" or "digital" designation signal is stored in association with each secondary preselected number. This designation signal tells the microprocessor the proper mode of communication for the number being called. An appropriate digital or speech format signal is generated and applied to a speech amplifier or a modem, and to the telephone lines informing the person or terminal at the preselected number of the alarm condition. Further in accordance with the invention, means are provided for sensing the presence of a telephone call to the device and determining whether the call originating station is equipped to communicate in the digital format or should be addressed in speech. If the call originating station is digital capable, that is, the call originated from a computer-like terminal or teletype-like terminal, status information is given in digital machine readable form in one of two modes. First, if the digital inquirer so requests, the device disconnects from the call and calls the first preselected telephone number and gives a status report in machine readable form thereby reporting local conditions and verifying the operability of the call originating function of the device. Second, if the digital inquirer does not request a call back, the device gives a status report in machine readable form on the initial telephone connection. The device also has the capability of giving a synthetic speech status report in response to a telephone inquiry. It is an object of the present invention to provide a local area monitoring device or system which will communicate alarm reports in either digital or synthetic speech formats depending upon the destination to which the report is directed. It is a further object of the present invention to provide a system which will monitor a selected area while unattended and send reports on conditions at the selected area to a remote location in a form which can be recorded or displayed without the need of an attendant at the remote location. It is yet another object of the present invention to provide a local area monitoring device which is usable by the hearing impaired. It is yet another object of the present invention to provide a local area monitoring device which is usable to TTY subscribers. It is yet another object of the present invention to supply a local area monitoring device which is usable by persons having a computer terminal or personal computer and wishing their computer terminal or personal computer to perform monitoring functions at a local area remote from the computer in an unattended or unsupervised mode. It is still another object of the present invention to provide a local area monitoring device which is easy to use, easy to install, reliable and inexpensive. These and other objects and advantages of the present invention will become apparent from the following description taken together with the drawings which will be described in the next section.

Regulation of MicroRNA-155 and Its Related Genes Expression by Inositol Hexaphosphate in Colon Cancer Cells. Inositol hexaphosphate (IP6), a natural dietary component, has been found as an antitumor agent by stimulating apoptosis and inhibiting cancer cell proliferation, their migration, and metastasis in diverse cancers including colon cancer. However, molecular mechanisms of its action have not been well understood. In recent years, microRNAs (miRNAs) have been reported to play important roles in a broad range of biologic processes, such as cell growth, proliferation, apoptosis, or autophagy. These small noncoding molecules regulate post-transcriptional expression of targets genes via degradation of transcript or inhibition of protein synthesis. Aberrant expression and/or dysregulation of miRNAs have been characterized during tumor development and progression, thus, they are potential molecular targets for cancer prevention. The aim of this study was to investigate the effect of IP6 on the miRNAs expression profile in Caco-2 colon cancer cells. 84 miRNAs were analyzed in Caco-2 cells treated with 2.5 mM and 5 mM IP6 by the use of PCR (Polymerase Chain Reaction) array. The effect of 5 mM IP6 on selected potential miR-155 targets was determined by real-time (RT)-qPCR and ELISA (quantitative Polymerase Chain Reaction and Enzyme-Linked Immunosorbent Assay )method. The results indicated alteration in the specific 10 miRNA expression in human colon cancer cells following their treatment with 5 mM IP6. It down-regulated 8 miRNAs (miR-155, miR-210, miR-144, miR-194, miR-26b, miR-126, miR-302c, and miR-29a) and up-regulated 2 miRNAs (miR-223 and miR-196b). In silico analysis revealed that FOXO3a, HIF-1α, and ELK3 mRNAs are those of predicted targets of miR-155. IP6 at the concentration of 5 mM markedly induced FOXO3a and HIF-1a genes' expression at both mRNA and protein level and decreased the amount of ELK3 mRNA as well as protein concentration in comparison to the control. In conclusion, the present study indicates that one of the mechanisms of antitumor potential of IP6 is down-regulation of the miR-155 expression in human colon cancer cells. Moreover, the expression of genes that are targeted by miRNA are also modulated by IP6.

Job configuration for semiconductor manufacturing is the technique in which silicon chips are assigned to sites on wafers, wafers are assigned to jobs, and jobs are released into the manufacturing line, so as to meet the demand for chips. The process is complicated by yield uncertainties of the line and the configuration constraints imposed by the technology of the line. Yield losses can occur at a job level, where every chip within a job is bad, at a wafer level, where every chip on a wafer is bad, or at the site level, where one or more individual chips are bad. In the static job configuration problem, the configuration is determined in an open loop fashion from data on the demanded numbers of chips and the yield uncertainties. A decision is made on the configuration, and the configuration is released into the line; neither cycle time nor the status of the jobs within the line are considered. There are several measures of performance for meeting the demand. The semiconductor supplier may be measured on its "volume serviceability," the percent of the volume of the demand that is met. In a more stringent measure of performance called "mix serviceability," the supplier is measured in terms of the volume of demand supplied, but is not credited for shipping parts in excess of their demand. "Set serviceability" is another measure of performance. A customer may order a specified number of sets of components, for example, the set of chips needed for a printed circuit board or module. In set serviceability, the supplier is measured in terms of the demand for complete sets that is supplied. Set serviceability is more difficult to meet than mix or volume serviceability. In meeting set serviceability requirements for the static job configuration problem, it is desirable that the configurations achieve the serviceability with the fewest number of wafers. Minimizing the number of wafers reduces the costs for the raw materials and reduces the number of wafers flowing through the line. The technologies used to expose wafers (optical, e-beam and retical) and test equipment limitations may impose constraints on the possible job configurations. Some semiconductor manufacturing lines process single part jobs, where every chip within a job is identical. The job configuration required for such a line is referred to as a single part job or SPJ configuration scenario. Other manufacturing lines have more flexibility and allow for multiple part jobs having single part wafers, where every chip within a wafer is identical, but wafers within a job may be different. The job configuration required for such a line is referred to as a single part wafer or SPW configuration scenario. Some manufacturing lines process multiple part jobs having multiple part wafers, where a wafer (and therefore a job) may be made up of a plurality of different chips. The job configuration required for such a line is referred to as a multiple part wafer or MPW configuration scenario. The logistics systems controlling the flow of jobs through the line may impose additional constraints on the allowable job configurations. For example, these systems may require that a job configuration having multiple part jobs with single part wafers be composed of several copies of the same standard job. In the multiple part jobs with multiple part wafers case, the systems may require that every multiple part wafer be identical, that is, there be a standard wafer, and every job within the configuration contains the standard wafer. A conventional approach to semiconductor job configuration is known as ground start ratio. According to ground start ratio, the number of chip starts is the ratio of the demand for the chip type to the overall yield of the chip type. This ratio is computed independently for each chip in the set. Because the job configuration data for each of the chip types is computed without reference to demand data, yield data or configuration data of any other chip type, the computation required for the ground start ratio is straightforward and does not require an excessive amount of time to compute. However, the survival rates of the chip types which make up a set are not independent of one another in determining the survival rate of the entire set. Consequently, the ground start ratio approach is ill-suited to suppliers measured by set serviceability. Furthermore, because the ground start ratio is computed independently for each chip type, it cannot be used to take advantage of the substantial potential serviceability increases gained by using single part wafer and multiple part wafer configurations. Therefore, what is needed is an apparatus and method for manufacturing sets of chips that achieves the desired serviceability using a reasonable number of wafers.

Wave energy buoys convert the energy of waves on a surface of a body of water, for example, from ocean surface waves, or waves formed in lakes, rivers, tidal estuaries, or other bodies of water, into electricity, which can be used to satisfy commercial and residential energy needs. Accordingly, wave energy buoys can, inter alia, reduce dependence on conventional fossil fuels. Conventional wave energy buoys use the rising and falling of the ocean waves to cause the buoy to move up and down, producing a resultant mechanical stroking within the buoy which is used to drive an electrical generator. Another conventional method of converting kinetic ocean wave energy into electricity is through the use of permanent magnets oscillating in relation to a conductive coil. As the magnets and coil oscillate relative to each other due to wave motion, electric current is created in the conductive coils. These conventional methods of converting kinetic ocean wave energy into electricity are generally inefficient since they only capture a small percentage of wave energy. This limitation is due in part to the device not being able to adjust to varying wave swells to maximize the generation of electricity. Thus, a conventional wave energy buoy cannot distinguish a wave having a greater height, wavelength, and/or speed, from a wave having a smaller height, wavelength, or speed. A conventional wave energy buoy with a fixed-strength magnet is prevented from maximizing the potential energy generated from waves with varying heights and force because where the magnet is too strong, the oscillation of the buoy is impeded reducing the amount of electric current generated in the coils. Further, where the fixed-strength magnet is too weak, the buoy will freely oscillate in relation to the coils, but the electric current generated in the coils will be less than the amount that could have been produced with a stronger magnetic field. Therefore, a conventional wave energy buoy using fixed-strength magnets of a constant strength magnetic field will not be able to optimize the potential electricity generated from each wave. Wave energy buoys can be organized into a wave farm, such as a coastal buoy farm. However, it is difficult to manage and control a plurality of buoys organized into a wave farm so that electricity can be efficiently generated on a large scale. The inefficiencies described herein with regard to individual conventional buoys are magnified when a plurality of buoys are networked together in a buoy farm.

Ocular delivery of cyanidin-3-glycoside in liposomes and its prevention of selenite-induced oxidative stress. Cataracts have become the leading cause of blindness around the world, which is mainly mediated by oxidative stress. N-trimethyl chitosan (TMC)-coated liposomes of cyanidin-3-glycoside (C3G) (C3G-TCL) were prepared to attenuate oxidative stress induced by selenite sodium in rats. C3G-TCL were prepared by reverse-phase evaporation method and then coated with self-synthesized TMC. The physicochemical properties were determined. A gamma-scintigraphy study was employed to evaluate the precorneal elimination of the radioactive preparations. The transcorneal visualization for fluorescence-labeled samples was determined by confocal laser scanning microscopy (CLSM). The in vivo anti-oxidative study using C3G-TCL was carried out in rats with selenite-induced cataracts by topical administration. The sphere-like morphological characterization of the vesicles was confirmed by TEM, with a size of 158.3 ± 2.8 nm and a zeta potential of 31.7 mV. The encapsulation efficiency was (53.7 ± 0.2) % as measured by ultrafiltration. C3G-TCL showed a 3.3-fold increment in precorneal residence time when compared with that of the (99m)Tc-solution. A TMC coating enhanced the transepithelial transport of liposomes to a depth of 40-μm in the cornea. Moreover, C3G-TCL could significantly elevate the activity of superoxide dismutase and catalase in lens and also show a considerable reversal of reduced glutathione activity. The lipid peroxidation in lens was strongly prevented when compared with that of groups treated with uncoated C3G-loaded liposomes. The coating material TMC for liposomes helps improve the anti-oxidative effect of C3G in vivo through prolonged residence time on the cornea and improved permeability in the corneal epithelium.

Screen time is independently associated with health-related quality of life in overweight and obese adolescents. Excessive screen time and diminished health-related quality of life (HRQoL) are greater problems for obese than nonobese adolescents, but no research has examined the relationship between these two variables. This study examined the association between screen time and HRQoL in overweight and obese adolescents. A sample of 358 overweight and obese adolescents aged 14-18 years were assessed at baseline between 2005 and 2010 as part of the Canadian Healthy Eating, Aerobic and Resistance Training in Youth (HEARTY) trial. We used the Pediatric Quality of Life (PEDS-QL) and other self-report measures to assess HRQoL and screen time, defined as how long the 261 females and 97 males spent viewing TV, using the computer and playing video games. After adjusting for socio-demographic variables, adiposity, physical activity and diet, screen time duration was associated with reduced overall HRQoL (adjusted r = -0.16, ß = -0.16, p = 0.009) and psychosocial HRQoL (adjusted r = -0.16, ß = -0.18, p = 0.004), but not physical HRQoL. No differences were found between males and females. Screen time was associated with reduced overall and psychosocial HRQoL in overweight and obese adolescents. Future research should determine whether reducing screen time improves overall and psychosocial HRQoL in obese adolescents.

Use of electrical vehicles is becoming increasingly popular due to the environmental benefits of removing pollution caused by fossil fuel burning vehicle engines from the environment, especially in densely populated urban environments. As with most mobile electrical devices, electrical vehicles carry electrical energy storage devices or batteries, which supply power to the vehicle propulsion and other systems. As can be appreciated, the vehicle batteries require recharging after usage. At present, electric vehicle recharging is accomplished by connecting a recharging connector into a vehicle receptacle manually. The vehicle receptacle is usually located in the same or similar location as a vehicle fuel fill spout. Such locations are protected by doors or lids, much in the same way vehicle fill spouts are protected from environmental elements, dirt and road debris. However, with the advent of automated electric vehicle recharging systems, the vehicle charge receptacles may be located elsewhere in the vehicle, including areas that are commonly inaccessible to users such as beneath the vehicle.

Pharmaceutical care practice in patients with chronic kidney disease. The impact of chronic kidney disease in health is no longer just a patient-physician issue, not only in terms of the increase in the number of patients diagnosed, but also regarding the human and economic cost for health systems. That is why Pharmaceutical Care should include SOPs structured by criteria reached by consensus to conduct Pharmaceutical Care Practice, which will enable to prevent, identify and solve any negative outcomes in patients that are associated with medication. Objectives: To learn about the types of problems related to medications and negative outcomes associated with drugs that can be detected, prevented and solved in patients with chronic kidney disease, through pharmaceutical care practice. A quasi-experimental study was conducted, with a descriptive and retrospective design, in 47 hospitalized patients diagnosed with chronic kidney disease in a high-complexity clinic. Using the DADER methodology, their pharmacological treatments were analyzed, and it was verified whetherthey were necessary, effective and safe, taking into account variables such as the negative outcomes associated with medication, medication-related problems, pharmaceutical interventions, and kidney failure stages. Results: Fifty-one (51) negative outcomes associated with medication were detected during the study; of these, 13.72% were for Necessity, 45.1% for Effectiveness and 41.18% for Safety. A total of 41 pharmaceutical interventions were conducted, 35 were accepted and 6 were not accepted. Of these 6 non-accepted interventions, 3 health problems were not solved, 12 dose re-adjustments were conducted, with cefepime as the drug with the highest number of dose adjustments; most patients were in Stage III and V of CKD, and its main cause was hypertension and Diabetes Mellitus II. The most prevalent NOMs were those for Non-Quantitative Insecurity, therefore these are a highly prevalent problem. This highlights the importance of this public health problem and its major clinical, social and economic impact, associated with Chronic Kidney Disease; therefore, it is necessary to involve all health professionals and patients, to obtain as a result a better use of medications, the prevention of NOMs and a reduction in morbidity associated with pharmacotherapy.

Efficacy of a new fractional CO2 laser in the treatment of photodamage and acne scarring. This study evaluates the efficacy and safety of a novel fractional CO(2) laser device for improving facial rhytids, hyperpigmentation, enlarged pores, skin laxity, and acne scarring. Subjects (n= 15) were treated three to five times at 3-week intervals. Biopsy specimens were used to evaluate healing response and neocollagenesis. Clinical improvement was rated on a quartile rating scale from digital photographs. Subject discomfort during treatment was evaluated on a scale of 0 to 5. Fourteen subjects who completed the study achieved good to excellent improvement in overall appearance, with 60% rated excellent. Improvement in photodamage was good to excellent in 92% of subjects, and reduction in rhytids was good to excellent in 85%. A total of 79% of subjects achieved good to excellent improvement in pore sizes and skin laxity. Subject discomfort during treatment was 3.0 +/- 0.7. Erythema persisted for 2-3 days, and subjects resumed normal activities 1-2 days after the procedure. Histological slides after a single treatment showed new collagen formation. The SmartSkin fractional CO(2) system (Cynosure, Inc., Westford, MA, USA) provides significant improvement for the treatment of facial wrinkles, hyperpigmentation, pore size, and skin laxity associated with photodamage.

1. Field of the Invention The present invention relates to the field of integrated circuits and, more particularly, to semiconductor devices having double lightly doped regions for improved DRAM refresh characteristics and methods for their manufacture. 2. Description of the Related Art Metal oxide semiconductor (MOS) structures are basic electronic devices used in many integrated circuits. One such structure is the MOS field effect transistor (MOSFET), which is typically formed in a semiconductor substrate by providing a gate structure over the substrate to define a channel region, and by forming source and drain regions on opposing sides of the channel region. MOSFETs are often used in the formation of memory circuits, including dynamic random access memory (DRAM) circuits. DRAM circuits are composed of an array of individual memory cells, each cell including a capacitor for holding a charge and an access transistor for accessing the charge held in the capacitor. In a typical DRAM cell using a MOSFET access transistor, after a charge is stored the charge does not remain in the capacitor indefinitely, but instead slowly leaks out of the p-n junction of the access transistor for the cell. This phenomenon is known as xe2x80x9cjunction leakage.xe2x80x9d To avoid losing the cell contents, the charge must be periodically re-stored in the capacitor through a process known as xe2x80x9crefresh.xe2x80x9d Increased junction leakage leads to premature depletion of the capacitor""s stored charge, necessitating more frequent refresh operations. Refresh operations consume device resources and it is therefore desirable to reduce junction leakage as much as possible and thus reduce the frequency of required refresh operations. Several factors are known to contribute to junction leakage, including (a) the electric field (E) generated at the p-n junction, (b) surface- or bulk-defect-induced recombination/generation current, and (c) gated diode assisted band-to-band tunneling leakage, such as gate-induced drain-leakage (GIDL) current. In particular, factor (a), the electric field (E) generated at the p-n junction, is proportional to the gradient of the doping concentration of either side of the junction. Because junction leakage varies directly with this electric field (i.e. higher E leads to higher junction leakage), it is desirable to control the doping concentration on both sides of the p-n junction. By controlling the doping concentration on both sides of the junction to reduce the gradient of the doping concentration, the p-n junction electric field (E) can be reduced and hence junction leakage. The gradient of the doping concentration at the p-n junction of a MOSFET in a DRAM array depends on the doping concentration of the channel region and the doping concentration of the ion-implanted regions adjacent the channel serving as source/drain regions for a cell access transistor. For example, in an NMOS transistor, the channel is doped with p-type impurities, the source and drain regions are doped with n-type impurities, and as the boundary between the p-type channel and the n-type drain region is approached, the rate of change in impurity concentration defines the gradient of the doping concentration. An abrupt change in impurity concentration from p-type to n-type doping at the boundary creates a high gradient, high electric field (E) and hence increases junction leakage. A more gradual change from p-type to n-type doping concentration, for example using lightly doped drain (LDD) regions, creates a relatively lower gradient, lower electric field (E) and hence decreases junction leakage. There are several tradeoffs that must be taken into account when formulating the doping concentrations on either side of the p-n junction. For example, in an NMOS transistor, the p-type doping concentration of the channel should be sufficiently high to turn off the transistor when the gate is off (i.e., low subthreshold leakage). On the other hand, the channel doping concentration should not be so high that a full potential of charge is prevented from being transferred from source to drain when the gate is on. Likewise, the n-type doping concentration of the source and drain regions should be sufficiently high to obtain satisfactorily low series resistance and threshold voltage. If the n-type doping concentration is too low, transistor current drive may be degraded and a wider depletion width may result, possibly leading to undesirable levels of reverse bias current. On the other hand, if the n-type doping concentration is too high, undesirable junction leakage effects can result as discussed above. Thus, it would be desirable to form the memory array taking the above considerations into account and produce memory cells in which the electric field generated at the p-n junction is reduced for each cell and hence reduce junction leakage. Another problem associated with the electric field generated at the p-n junction is the xe2x80x9chot carrierxe2x80x9d or xe2x80x9chot electronxe2x80x9d effect wherein energetic charge carriers, typically electrons and/or holes, are accelerated by a strong electric field, such as that created at the p-n junction. Such high strength electric fields accelerate the energetic carriers, known as xe2x80x9chot carriers,xe2x80x9d toward the gate electrode and the underlying gate oxide. These hot carriers are thus injected into the thin dielectric layer of the gate structure and into the adjacent thicker dielectric gate spacer structure, resulting in damage to the gate oxide as well as to the gate spacer structure. Over time, these hot electrons create a permanent charge in the thin dielectric layer and the dielectric spacers, degrading or destroying the performance of the associated MOSFET device. This is typically more of a problem with N-channel MOSFETS (which have electrons as the primary carrier species) than P-channel MOSFETS (which have xe2x80x9cholesxe2x80x9d as the primary carrier species). The above problems are well known in the art and have resulted in the widely practiced remedy of forming lightly doped drain (LDD) regions between the source/drain regions and the channel region in the semiconductor substrate. This LDD region reduces the gradient of the doping concentration at the boundary (p-n junction) between the source/drain regions and the channel region to thereby lower the strength of the electric field (E) generated at the p-n junction. This reduction in the electric field (E) results in decreased junction leakage and reduces the hot carrier effect. For example, U.S. Pat. No. 4,366,613 to Ogura et al. (xe2x80x9cOguraxe2x80x9d) discloses the formation of LDD regions in a RAM MOSFET. Referring to FIG. 1, MOSFET device 5 includes a gate structure comprising an access gate conductor 16 and a gate top insulator 20 formed over an oxide layer 18 that is formed on a substrate 12. Insulating spacers 32, 34 are formed on sidewalls of the gate structure. The device also includes source/drain regions 36, 38 and two lightly doped regions 22 and 24, one of which is provided proximate to each of the source/drain regions 36, 38. A channel 15 extends between the LDD regions 22 and 24. By providing the LDD regions 22 and 24, the electric field at the p-n junction between the channel 15 and the source/drain regions 36, 38 is reduced, thereby reducing the junction leakage and the hot carrier effect. The prior art LDD structure of FIG. 1 can be made by a variety of processes, but is typically made by providing a low-density ion implant of the LDD regions 22, 24 before adding oxide spacers 32, 34 to the gate structure (see U.S. Pat. No. 4,366,613 to Ogura). After the spacers 32, 34 have been added to the gate structure, a higher-density ion implant is made to form the source and drain regions 36, 38. Since the source and drain regions 36, 38 were implanted after the formation of the spacers 32, 34, they are offset further from the channel 15 than the LDD regions 22, 24. The resulting structure exhibits a decreased electric field at the p-n junction. Although LDD structures have helped advance the state of the art, increasing competition in the semiconductor industry, particularly in the development of DRAM devices and methods, have created a need and desire for greater device performance, especially in the area of lower refresh rates. It would, therefore, be desirable if the problems of junction leakage and hot carrier generation at the p-n junction could be further reduced in a MOSFET access transistor of a memory cell, using conventional processing and manufacturing techniques and at a reasonable cost. The present invention provides a technique for forming double LDD regions at the p-n junction of a MOSFET access transistor of a memory cell that reliably improves the refresh characteristics of DRAM memory devices without substantially increasing manufacturing costs, with the added benefit of LDD peripheral devices resistant to hot carrier effects. The above and other features and advantages of the invention are achieved by providing a DRAM memory circuit composed of novel integrated circuit devices, and a novel method of making the devices, including a memory cell with an access transistor with double LDD regions in addition to lightly doped LDD regions in a conventional metal oxide semiconductor field effect transistor (MOSFET), with or without using an additional mask. In the process of making the devices, a semiconductor substrate is provided with a gate structure formed on its surface, thereby defining a channel region in the substrate beneath the gate having a source side and a drain side. Next, lightly doped LDD regions are formed adjacent to the channel region by ion implantation in the substrate. Then, insulating spacers of a first width are formed adjacent to the sidewalls of the gate structure covering at least a portion of each of the LDD regions. Next, the memory array portion of the DRAM circuit is masked and heavily-doped source/drain regions are formed in the unmasked periphery MOSFETs by ion implantation in the substrate. The mask is then removed, and the insulating spacers are etched back to a second width smaller than the first width. Then, double LDD regions are formed by lightly doping the substrate in the memory array and in the periphery MOSFET areas. The structures formed in this method permit reduced channel doping in the memory array, reduced doping concentration gradient near the p-n junction, and hence a reduced electric field at the p-n junctions in both the memory array and peripheral MOSFETS. The present invention thus provides an improved doping profile at the p-n junction between the channel and the source/drain regions, thereby improving DRAM refresh characteristics by reducing junction leakage. In addition, the hot carrier effect is reduced for periphery MOSFETs. Furthermore, these favorable results were obtained using conventional masking and etching techniques, obviating the need for unconventional processing techniques at a higher cost and failure rate.

"They're all gone" "Go over there" "What's for?" "Just go on" "What the hell is it to you if I go to the 'Ladies'?" "You dare report me to the old woman" "I didn't" "I'll beat you up" "Stop..." "We can stop but from now on you'll have to pay us 30 cents protection money" "Then we'll not beat you up nor will anyone else dare, pay up" "I have no money" "Brother, that gang is bullying Man Chai again" "Let's take a look" "What do you think you're doing?" "What's up?" "You bully him because you are outnumbered" "He wanted protection money from me just now" "Kid, not even I have asked you lot for protection money and you dare ask him for it?" "You must be tired of living" "You dare to be a busybody here" "I'll beat you up too" "Stop, do you know who my father is?" "I don't care if he's the governor himself" "My father is known as the Uncle Loong" "Did you know that?" "Nope, although I've eaten lots of loong ha (Iobsters)" "Are you trying to insult my father?" "Beat him up" "Run, quick" "Chase him, stop..." "Stop, don't run..." "Bastard, you dare hit others" "You overturned my stall" "You two bastards again" "Bastard" "If you have the guts look for me at school tomorrow" "Would I be afraid of you?" "What's the matter, bluffing?" "If you're still here we'll beat you up too" "What's the big deal?" "You kids fight all day" "I'll tell your fathers" "Please don't, brother Wang" "We dare not next time" "Yes we won't dare" "Go on quickly" "Goodbye" "Da De, Xiao De" "Are you two alright?" "Yep." "Would have killed them if they didn't flee in time" "Let's go" "Do we have 5 cents, I'd like to eat sweet beancurd" "Where do we get money for it?" "You spent the last cent this morning" "Let's go" "Xiao De" "You must be enjoying huh, we fought for you just now and you're hiding here now eating sweet beancurd" "I'll treat you, then" "What are you doing?" "They asked you for 30 cents and now you treat us to only 5 cents' won'th of sweet bean curd" "That's all I have, eat up" "What's there to look at, go away" "Pretty girl" "Do you want to know the colour of her panties?" "Do you have the guts to ask her?" "Never mind, how much do you have on you?" "30 cents" "Give the money to me" "What for?" "I'll make you a bet" "I'll pull up her skirt for you to have a look" "Give me the money" "Alright" "Da De, your brother really has guts" "Great fun" "Sex maniac" "You devil, pulling up my skirt" "Stop" "Are you shameless?" "Policeman, he pulled up my daughter's skirt" "Arrest him" "What's your name?" "Where do you live?" "I'll report you to your school" "What a bad kid!" "Little tramp" "Stop" "Don't run" "Xiao De, let's enter the city" "You go that way" "Stop" "You're looking for death" "Bastard" "Mister, have a seat" "I have no time, I have to work" "Little brother, what's up?" "Where's the policeman?" "He doesn't have the guts to come in here" "Bullshit." "If not for me, you couldn't have escaped" "Go and look for ninth uncle quickly" "Strip..." "It's said, 'Touch a bra you get 3 years' bad luck' you touched the panties, you'll surely have bad luck for the rest of your life" "Touch wood" "Come out..." "Please be quiet" "I'm not performing this show" "This show will be exciting it features two lovers" "Hold on to your tickets if you've got them if not go and get them quickly" "If you're not watching, please go" "May I present Leung Shan Pak please" "Come out quickly" "Please" "Your wife refuses to appear up, speak to her quickly" "Go quickly" "No way, over my dead body" "Not unless I'm dead" "No, you're shameless, do it yourself" "I'm not doing it..." "What's to be afraid of?" "I've got payment already" "Let's pretend we're doing it at home" "I'm not as despicable as you" "You have to do it" "No way, never" "Where are you going?" "To get Shing's wife" "Forget it, he is way out of line to force his wife to do such a thing" "Forget it, find another one" "Where?" "Go and look" "Friend, have you bought a ticket?" "Yes" "Go on inside" "You two little devils" "Ninth uncle what are you doing here?" "To see you" "What for?" "Have you eaten?" "If not, eat with my dad" "I have no time now, I'll go later" "20 cents each" "Thanks" "Help, robbery" "Robbery?" "I have no money" "Beat him" "Help, robbery, I have no money" "Run, quick" "Kids..." "This way please" "A empty seat over there" "4 bamboos" "Eighty thousand" "I win again" "Sorry, pay up" "You're playing a smooth hand winning all the time" "You've won a lot today" "Not a lot, just having fun" "Go and play at a bigger table (bigger stakes)" "No need, just having some fun will do" "Friend, someone's waiting for you outside" "I am winning now" "He said it's urgent" "Right, go and look" "What for?" "Don't worry" "Ah Chu" "Damn" "What?" "Why are you treating customers like this?" "Customer?" "You think I'm an amateur?" "Why are you beating me?" "Do you take me for a swindler?" "If you can't explain, I'll make this publicly known" "Be careful" "Shut up, we're going to fix you" "You have no right to search me, let go" "No right?" "This is our right" "Stop" "You've come in good time" "If you can't find anything, it means you're bullying me" "Can one only lose but not win here?" "Brother, we never bully anyone and no one bullies me" "Bastard, do you still deny cheating?" "I have not framed you, have I?" "You dare to hold this in your mouth, not a drop of saliva too" "Enough..." "Listen, don't ever let me find you here again or I'll maim you" "Father" "Kid, what are you doing here?" "Get out" "Ah Sing, give him some money to visit a bone setter" "My son" "Father" "I told you to get out, why are you still here?" "Where's your little brother?" "Downstairs" "Father, we're so hungry" "Go down and wait for me" "Xiao Li, I'm going to Mei Wa to have a meal look for me if there's anything" "I'll wrap it for you" "Give me ten cents to buy something to eat" "Right, 20 cents would be nice" "It's fixed" "How smart" "Quick enough?" "Yes" "Arert you afraid father would find out you're wrapping cocaine for others?" "Kids" "Father" "So quick" "What are you all doing here?" "Nothing" "Hungry?" "Yes" "Let's go" "Uncle Loong" "How many times have I told you not to set up your stall in front of my entrance" "Yes..." "If I see you again when I return, I'll burn it all" "Get lost now" "Mister, come over here" "Kids, did you smell that?" "Such a nice aroma it will tempt even papa" "Bastard, if I can't stand firm (tempted)" "You're in trouble" "Dad, you're joking" "Let's go" "Uncle Loong, have a seat" "What's good to eat?" "Naturally we have the good stuff" "We've just cut up a small black cur;" "plump and smooth" "Have a catty" "Dad, have two catties instead" "Ninth uncle will come in a while" "Two catties" "Okay" "Two more taels of "fox bone" wine" "Right, dad?" "Smart, coming" "Dad, what happened just now?" "That fellow wanted to be a cheat" "Really?" "At my dad's mahjong house?" "He must be tired of living" "Shut up" "You two have finished school for so long where have you gone?" "A friend fell and hurt himself, so we helped him" "Right, brother?" "That's right" "You want to deceive me?" "Have you been fighting?" "No, father" "Da De, Xiao De" "Ninth uncle" "Come over here" "Make way... it's hot" "Ninth uncle..." "How's the shop doing?" "Still the same" "Let me" "Dad, is the wine good for the kidneys?" "Dad, Ninth uncle if so then it's won'th a try we want some too" "Right, aunty Wa" "No, you're under aged, no wine" "I'm not doing it" "Let me go" "You can't hide forever" "I'm not doing it" "It's not up to you" "Stop beating" "None of your business" "Beat you to death..." "Beat me?" "Are you out of your mind?" "Are you nuts?" "You want to kill your own wife?" "What a scumbag, only just now he forced his wife to host a real show at my place, he is not human" "You've lost everyone because of your drug habit" "Alright, you go back first" "No way, never" "Where are you going?" "What do you want?" "What else do you want?" "Nothing" "She's my wife, I can do whatever I like with her" "How could you ask your wife to do such a thing?" "Why not?" "If you paid me" "I could ask her to sleep with you" "Addict Shing don't ever expect to get cocaine here again" "Let's not waste time on this bastard a waste of our efforts, let's go" "What are you looking at?" "Look..." "I'll take off my pants for you to have a look..." "Shameless" "Damn" "Dad, for you" "Where did you get it?" "You tell me" "Quick" "We saw a robbery just as we finished school and also saw a pack of cigarettes on the ground so little brother picked it up" "What have I been teaching you?" "You can't even look after you kid brother and let him steal from a robbery" "It's not my fault, he picked it up himself" "You dare to answer back?" "One should not pick things up from the street" "How many times have I told you" "I told you not to run around after school and yet you've come to the mahjong house to look for me" "Come here" "Dad, I won't do it again next time" "That's what you say each time" "It's because I didn't study hard as a kid that I now have to work in the mahjong house" "If you don't study hard how could you have a career in society?" "Get me my clothes" "Wipe away the blood" "Thanks, dad" "Teach your kid brother to study hard he's failed in a few subjects according to his report" "Yes" "Luckily dad didn't beat me" "Easy for you to say" "You picked up the cigarettes but he beat me you failed and he scolded me" "Take out your books and study" "I think dad is over doing it" "What's the use of studying so much?" "Inside Kowloon Walled City everyone knows my dad is Uncle Loong" "When I grow up" "I could get a job easily" "Shut up and get your books out to study or dad will beat me up again when he returns" "Alright" "You take care the place" "Uncle Loong, good morning" "Good morning" "Good morning" "Good morning, where's the money?" "Here" "Hurry up, we'll be late again" "Look at your books, they're all in my bag" "This is yours" "There's more" "I guess that punk wouldn't dare beat me again today" "He wouldn't dare" "Of course" "Kids" "Father" "Dad" "Dad..." "Dad..." "Don't run..." "Don't..." "Dead, what to do?" "Dead?" "What to do?" "Father" "Father..." "Don't die... dad..." "Don't die... dad..." "Dad, don't die" "Get ninth uncle, quick" "Get him quickly" "Dad, don't die" "Don't die" "Dad, don't die" "Dad..." "Don't cry" "Well, not bad, huh?" "Xiao De, come on you're not flying an airplane if you crash, nothing I do can pay for the damages" "If we crash, you do us a favour to fix it" "Don't worry as long as my husband is driving" "My wife knows me well" "Good car" "Of course, it's a Porsche" "What' the big deal?" "The car is great, but the people in it are not" "Sit tight" "Look... there's a railing in front" "How dangerous" "Of course, this is mid-night Grand Prix" "This I have to see" "Come on..." "I'm doing it right now" "None of your business" "Faster..." "Look, so many people" "Great fun, can't take anymore, speed up" "Hope your car crashes!" "Damn, I'm finished, this car's a total loss" "Don't be like that, there are people around" "Mr. Cheung, why haven't you looked me up for so long?" "Stop uttering rubbish" "Didrt you say you have a new girl for me?" "A new girl?" "Girls these days don't know how to please unlike us, who were so gentle and beautiful" "Unfortunately I'm ten years older than you, or else..." "Who's talking about age with you?" "We talk about this now" "Right..." "Are you introducing me to the new comer?" "Yes, let me think" "Lily is too tall for you" "And Mary?" "She is repugnant don't get her" "Mimi looks good but her figure is not good" "Thanks boss" "Cheung the great is calling you" "What can I do for you?" "I am taking all the girls today except for her and her bunch" "Thanks, mister Cheung" "What's the big deal?" "So lascivious and disgusting" "Da De, do we have to start the show later tonight?" "It's about time, start as usual" "Officer Cheung is waiting for you inside the room" "Thank you" "Where's uncle Biu today?" "He's gone to Singapore and won't be back till next week" "Oh man, I've got to hand it to him" "He's over sixty and has a few families how does he do it?" "Uncle boasts of his figure" "Officer Cheung, sorry" "Excuse me" "Enjoy yourself, we'll talk later" "No problem" "He says uncle Biu is good" "I say officer Cheung is even better" "Obviously just look at his nose" "Let's drink" "Coming" "Coming immediately..." "Ladies, sit over there please" "Go over there" "Over there, see?" "See how they are enjoying themselves" "I'll have a little fun with them" "Think of a plan" "Right..." "let's release the air from his tyres" "That's childish, not much fun" "Let's scratch his car" "No meaning" "Let's crash his screen" "No, if we're caught we'll be beaten to death" "C'mon then, think of a way." "You do claim to be smart" "That's because I love to eat" "Never mind the bullshit, think of another way" "Damn, it's so frustrating" "That guy was so detestable" "He wouldn't buy more time with me yet he wants me to have a late snack with him there wouldn't be much benefit if I went right?" "Mine's even worse, he bought two hours and his hands were all over me" "Why didn't you slap him?" "I did even better, I touched him too" "He would have died for that" "What are looking at, bastard?" "Don't recognise me?" "Even a good man fears an abusive woman" "What?" "You bastard" "Have I stepped on your tail?" "You have a cur's stinking mouth" "You bitches, I'll give you a good beating" "What?" "Would I be scared of you?" "Forget it, sit down" "Miss, I apologise" "If you want to mess around, go home" "Please, be quiet, forget it..." "You dare mess with me?" "Officer..." "What's the matter?" "There are two suspicious characters over there" "I don't know what they're doing, please check them out" "Where?" "Over there" "Take me to them" "This deal could bring us lots of money" "Right" "Officer, here they are" "Hurry, the police is giving out tickets" "I'm sorry, Officer, I'm leaving immediately" "I am sorry" "Big Brother" "Who did this?" "I don't know" "Come, come over" "Get hold of them" "Stop, clear it up before you go" "What fun!" "That big-mouth bastard can't do anything that was quite an exciting scene" "What a thrill!" "What's going to happen to him next?" "Maybe he has to pay for the indemnity or maybe he'll be taken to the police station" "Wait, can they identify us?" "Hong Kong is such a big place how could we be recognized so easily" "Even if they did, what could they do?" "TRUE" "What's there to be afraid of?" "Let's find some entertainment" "Hurry" "Get off..." "Hurry..." "Get off..." "This is a nice place" "What are we doing here?" "Barbeque?" "Tell me early" "Barbeque?" "Screw you, eat them yourself" "Ah Ling, let's go over there" "We're leaving too" "Alright" "What about me?" "You enjoy yourself" "Don't dirty the car, make use of the tissues in there" "The tissues are too coarse, you must be joking" "Xiao De" "What?" "My period is late for 10 days" "No way!" "You said it was your safety period that day" "Maybe it's because you are not feeling too well." "Right?" "No." "Don't" "Don't" "Let go of me" "What are you doing?" "No" "No" "No..." "Don't stop" "Hurry..." "Hurry" "Hurry" "Don't panic, I can't do it in a hurry" "Hurry" "The condoms are all used up" "What?" "I just bought you over a dozen last week and you've already used them all?" "You bastard" "You bastard asked me to give myself relief" "It's you do it now" "I don't want to tonight" "But I do" "Sorry to interrupt you" "You haven't paid your tuition fees and want to learn?" "It's a fair world" "Alright, each one will provide relief for himself today" "Damn it" "Don't run" "You should leave, your brother is home already" "I have to go too, dad will be back soon" "Alright" "Are you going to meet another woman?" "You got it wrong, three a day" "I'll take you back" "You drink a lot tonight" "Didrt expect you to be a strong drinker" "You're not bad yourself" "I couldn't get you drunk" "It's a robbery, officer." "Shouldrt you make an arrest?" "Not yet, wait until they've got the money then we can catch them red-handed or we can be sued for wrong accusation" "Three hundred dollars only?" "Give me the pearl necklace" "No" "It's from my Mom" "Give it back to me" "Don't move, or I'll shoot" "They robbed me" "Come over" "Drop the knife" "Damn, don't move" "Officer, it has nothing to do with me" "Come over" "It has nothing to do with me" "Beat you up" "Go over there" "Handcuff yourself" "This is called caught in the spot" "Da De, call the station for me" "I'll handle the case here" "Yes, Sir" "Miss, are you alright?" "Hot dumplings..." "Give me one" "Thank you" "Hot dumplings..." "Brother, you're back" "Yes" "Brother, have some dumplings" "Keep it for yourself" "Brother, you've bought one too" "Yes" "How can I have two?" "I'll eat with you" "Brother, I'll make some tea for you" "Xiao De, how can you go to school when you stay up late every night?" "I've finished my homework at night so I can sleep a bit more during the day" "Brother, it's fun to have a second-hand car" "Do you have a driver's licence?" "No, but I can drive" "Wait until you get one" "Don'tjust keep reading this stuff all day pay more attention to your study" "It's fun" "The physics teacher saw you and you didn't even know" "Only you can think of such a thing" "You are stupid enough" "You should have someone on the lookout" "How come you are so stupid?" "Goodbye" "My dear, you're so early" "It's so rare" "It's so rare" "What is it?" "What else?" "Must be total failure" "It's no surprise" "What do you want to eat?" "Nothing" "How about you?" "Dear, have you really failed in all subjects?" "Take it out, I'll change them for you" "Not this time" "Dad will surely kill me" "Don't cry, let's think of a way" "What else can we do?" "Don't be like that" "Do you want to let the whole world know about it?" "What am I going to do?" "What to do?" "Had you listened to me everything would have been alright" "What has that to do with me?" "Every time you say it's alright" "Lower your voice, please" "You've now made a mess wanttoblameitonme" "Don't cry" "What are you doing?" "You can shun the responsibility" "Stop shouting" "What is it?" "Having failed is no big deal, why scold her?" "Shut up, nobody will think you're dumb" "He..." "What is it?" "Nuts" "Hey kid" "Tastes good huh?" "Brother, do you recognize me?" "We had a car race the other night" "Which night?" "Let me refresh your memory" "Remember?" "A little bit" "Yes..." "Where's that bastard who drove the car?" "I don't know" "I don't know" "Don't you know now?" "Yes..." "Where does he live?" "I don't know" "Where is he now?" "I don't know" "Yes..." "Will he be coming?" "He..." "Is he coming or not?" "He..." "Speak up" "Yes..." "When?" "When?" "Uncle, don't meddle in our affair, alright?" "Stop talking nonsense" "Xiao De, run, run" "Don't run..." "Stand still" "Are you blind?" "Sorry, Sir" "Sorry, Sir" "Sorry, Officer Cheung" "What happened?" "You are more fierce than I am chasing and beating people in the street" "That bastard fooled me" "I don't care" "Behave yourself or I'll arrest you" "It's not that serious, is it?" "Behave yourself, go" "Arert you leaving?" "What are you standing here for?" "What's the big deal?" "You are all useless, you can't even catch that bastard" "Find him, or never see me again" "No" "Abortion is bad for the body and is dangerous" "I won't allow you to do that" "Mom, what am I going to do now?" "Mom" "You dad is back now clean up your face" "I'll find a chance to talk to him" "What are you doing?" "Preparing dinner" "Dad" "Ah Ling, don't go back to your room yet" "Sit down, let's chat for a while" "How come you didn't go out today?" "Your eyes are red, have you been crying?" "What happened?" "Have you been bullied?" "Tell me" "It's nothing" "Maybe the contact lenses don't fit" "Nothing's wrong" "Get a new pair if they don't fit be careful not to hurt your eyes" "Yes" "Did the schools give out the report cards today?" "Yes" "How did you do?" "I'm asking you" "Eighteenth" "Not bad" "Show it to me" "Have some tea" "Dad" "Who's this guy?" "A classmate" "A classmate" "It's really my classmate" "You lied to me" "You two are too close to be ordinary classmates" "Speak, who is he?" "Dad, no... dad" "Are you telling or not?" "Speak, who is he?" "Why are you hitting her?" "Calm down" "See how you teach your daughter" "The poor girl could be cheated in some days and you are still kept in the dark" "Mom, see for yourself" "If he knew, he would surely kill me" "Wait until he's calm, I'll think of some ways" "Go in" "What are you doing?" "Take him out, see how fast he can run" "Go" "Go" "Try to be cool?" "Go" "Sit down" "What are you doing?" "Has this bastard committed rape?" "No." "He's running naked in front of a girls' school" "Officer, that's not true, I've been set up" "Don't frame me" "What, will the police frame an innocent person?" "We'll find out" "Okay." "Officer Cheung likes to have fun with those punks" "Alright, he's all yours" "Okay" "Officer Cheung is here" "Stand here" "Bring him out later" "Officer Cheung, he's yours" "Officer" "What happened?" "This bastard is blatant" "Blatant?" "I'll teach him in his place in a while" "Come over" "Officer" "Go" "What about him?" "Bad conduct" "This bastard ran naked in front of a girls' school" "Ran naked?" "Kid, are you well hung?" "No, Sir, I've been set up" "Sir, your daughter and I are good friends" "if you don't believe me, you can ask her" "Kid, don't make some empty claims" "What do you want?" "Come with me" "We are investigating this case" "You can bail him out for the time being" "Thank you" "Ah Sing, is Chan Ka Cheong here yet?" "Yes, Officer Cheung has taken him to his room" "Follow me" "Alright" "Brother" "He is your brother?" "Look at you." "Very soon you could be beaten to death" "He's careless" "Officer Cheung, you beat up every suspect in each case" "I just go by the book." "You can file a complaint, though" "Never mind..." "Make the necessary arrangements for your brother, go" "Wait" "Ask your brother never to see my daughter again" "Brother, you have to trust me" "Brother, listen to me" "Brother, help me" "You've to stick your neck out for me on this one, bro" "Stick my neck out?" "If I stuck my neck out you will be beaten to death" "It's not my fault, that bastard stripped me of my clothes and shoved me on the street" "Help me please" "Why'd others mess with you if you don't bother them?" "How come no one has bothered to take off my pants?" "A naked Danish hen is hopping everywhere, so disgusting" "Do you agree?" "So what?" "I'll expose you for peeping at your sister bathing" "Alright, I will not talk" "That big-mouth bastard is so arrogant" "Ask your big brother to fix him" "Nuts" "If you want to fix him for such trivial matters then many other people would have to be fixed" "So you are letting this go?" "Why bother my elder brother, won't I do just as well?" "Anything could be fixed except bullshit" "Exactly" "The truth is he dares not tell his elder brother" "You have a point" "You insult me" "You are good at insulting the people only" "You bothered him while he was taking drugs, right?" "Go up and think of something" "Well, any ideas?" "You lot are so useless, think of something quick" "You guys are so frustrating" "Let's douse him with urine" "Let's make it worse for him" "How?" "Add some shit to the urine" "Where do we find so much shit and urine?" "We'll each contribute" "Wouldrt that be enough?" "No" "Xiao De" "Xiao De, I have a plan, it must work" "Wait" "Bring that big-mouth bastard back in a bag" "Tie him up and feed him with cocaine" "If he won't take, we'll surround and smoke him with it so that even by smelling, he'll get hooked" "Wouldrt that be revenge for us?" "You must be crazy, we will all get hooked before he does" "I grew up among drug addicts how come I didn't get hooked?" "Xiao De" "Calling you?" "You try to pick up girls like others yet you create so much trouble, go on..." "What is it?" "Think" "What is it?" "What are we going to do?" "Let me think of something" "You are procrastinating" "Did you know that my mom knows" "Your mom... how about your dad?" "What difference does it make?" "You've never thought about me" "Xiao De, I've got an idea" "Where's Ah Ling?" "Don't bother with her, speak" "Dad" "Ah Ling, what's going on?" "Nothing" "You can't hide anything from me since you were small" "Tell me" "Has someone molested you?" "No, Dad" "There must be something wrong, tell me" "So, you won't speak, right?" "That's fine, I can find out anyway" "If I find out that kid has touched you" "I'll break his bones" "Dad, don't" "You're nervous, something must have happened" "Have you been cheated?" "By whom?" "Speak" "Speak" "No one has cheated me" "Who cheated you?" "Speak" "Why have you beaten her again?" "It's not her fault" "It's useless even if you beat her to death she's pregnant for 2 months" "Do you want to kill the baby too?" "Bitch" "Mom" "Cheung Mei Ling" "Who's Cheung Mei Ling?" "Here" "Go in" "Go on" "Quick..." "Is it done?" "He's coming" "Unless he's diabetic, otherwise there'll be trouble" "Is it working?" "Yes" "They are here" "Have a seat" "Brother Ching" "The bill?" "Here it is" "Brother Ching" "Coffee again" "And you?" "No" "See if the amount is correct" "The money?" "Here it is" "I don't want to drink this, you go ahead" "He's not drinking it, what should we do?" "Brother, I'm going first" "Okay..." "let's go" "Waiter, plain tea please" "I got a idea" "What's up?" "Nothing, your tea is not hot enough" "This would create a big trouble" "We can't let him go no matter what" "Stop nagging, get prepared quickly" "Go on" "Tea and milk" "Thanks" "Coming" "Quick" "What's the matter?" "I can't hold back any longer, please come out" "Excuse me..." "Come out quickly" "Come out quickly, what are you doing inside?" "Come out quickly" "I just came in" "He's been in there a long time" "Come out quickly" "Quick..." "Damn it" "Come out quickly, someone's waiting" "Come on out" "You've saved even the room cost" "Excuse me" "Friend, are you finished?" "So many people" "I can't take it anymore" "Make way" "What?" "Go away" "1, 2, 3, 4... 6, 7, 8, 9" "The ninth" "Done" "Burn it shorter" "Make a boat" "Itjust like an aircraft carrier" "Pour the gasoline in" "That's enough" "That bastard, I want to burn him to death" "Too much" "The more fire the better" "Careful" "With this fire we are avenged" "That's right" "Be careful, use matches" "Hurry..." "Hurry, be careful" "If it's so much pain then stop it" "You must be the one who set the fire" "Not me" "Bright moon shines on ground, firering shines on ground" "You bastards again" "Don't run..." "Help, a molester" "Help, a molester" "Someone's molesting me" "Help..." "Make way" "He's doing dirty deeds" "What have you done?" "Why are you doing dirty deeds?" "Let go, go away, let me go" "What have you to say for yourself?" "Go away" "Help, molester" "Stop, go away..." "He molested me" "Stop running" "Stop, or I'll beat him up" "Isn't it fair, bastard?" "Go away" "There's no point talking to me" "I must find my brother before I can give you a reply" "Alright" "I am giving you face by talking to you" "Listen carefully" "If your brother don't apologize to me by tomorrow you'll die" "Follow me" "You have guts" "How dare you bargain with my big brother?" "Brother" "We are specifically here to apologize to Brother Ching not to bargain with him" "Xiao De do you know the rules?" "You mean..." "There's seniority for everything" "Be respectful if you're here specially to apologize" "Kneel" "Kneel" "Wait" "Before he drinks it, I have a condition" "Speak up" "Hold a feast for these men of mine to give them some face" "Brother Ching, you have been given due respect we are all out here to make a living let's drink tea and forget our grievances" "If I just drink it that's fine for me but not my men" "Alright" "If after you have drunk this cup of tea any brother who is still not pleased and wants more perks, he can look for my Ninth uncle" "He's your uncle?" "Ninth uncle retired a long time ago" "He won't want to be bothered by our matters" "We should give him face" "Since he's your uncle, I'll drink it" "It's hard to believe that the son of" "Chan Yuan Loong, previous chief of the Walled City is kneeling and apologizing to me" "Little brother" "Don't mention my father" "Don't move, let's talk this out" "Xiao De, what else do you want to say?" "You have guts" "You..." "Don't fight" "Ninth uncle..." "Uncle Jiu..." "You guys brought weapons along with you do you want to kill your uncle?" "No..." "Ah Ching" "What have my nephews done to incite them to fight each other?" "Ninth uncle, he started it" "What could I do?" "Ninth uncle, he insulted my father" "Yi Ching, doesn't matter who's right or who's wrong give some face to Uncle Jiu" "For any problem hereafter look for big brother and me and we'll take care of it for you" "Alright, since Ninth uncle is involved, we'll let it go" "Tell you nephew not to meddle with me again otherwise don't blame me for not giving you "face"" "Alright" "Go" "Ninth uncle, we'll be leaving" "Ninth uncle, see you" "Don't worry, it'll be alright" "Ah Jiu, go and have something to eat with him" "Xiao De, you stay" "Xiao De, do you realise what your brother has done for you?" "You've got yourself into big trouble" "Never mess with them again otherwise I won't be able to save you" "Yes, Ninth uncle" "Don't move, police" "Officer Cheung, what's the matter?" "Turn on the lights" "Ask the person in charge to come out" "Yes" "Look around" "Yes, you guys look over that side" "Come..." "Officer Cheung, what's the matter?" "Spot checking" "You should know better that you can't do it here" "I've talked to you on the phone about Xiao De" "How's it going?" "I talked to his big brotherjust now" "Let it go then" "Chief, what have you got?" "Most of them are juveniles" "Please do me a favour" "If I do, who's going to do me a favour?" "How's it?" "Alright" "Let's go back" "Go..." "Havert you cried enough?" "You're crying for an hour" "Look at you, you look like a dirty cat" "Who's going to marry you?" "Disgusting" "Why are you smoking?" "It's been rotten luck these days" "My brother doesn't help me when I'm in trouble" "I really wonder whether we have the same mother" "Xiao De" "Big Brother, those bastards are up there" "I want a leg of Xiao De, get it?" "Go" "That way" "Don't cry..." "Run" "Don't run" "Come out" "Let go of me" "Come here..." "No" "Come out" "No" "He is not here" "Search everywhere" "Don't cry, please" "Nothing, look over there" "Found anything?" "No" "Nothing" "That's weird, look over there" "It's so dark" "Ah Fu" "What is it?" "Look over here" "Alright" "I'll have a look" "Come up here" "Where are you running to?" "Go" "Don't run" "Here" "Hurry, run" "Big brother" "Break his leg" "Attack" "Xiao De" "Xiao De" "Xiao De, stop fighting" "Xiao De" "Run, hurry, run" "Hurry" "Hurry" "Ah Ling, come here" "No, I'm scared" "Hurry, they are coming" "Help, Xiao De... help me" "Hold tight" "Help me, Xiao De" "Xiao De, hurry and pull me up" "Hold tight" "Xiao De, help me" "Hold tight" "Xiao De, help me" "Xiao De, help me" "Ah Ling" "Hurry, go" "Ah Ling..." "Ah Ling" "Bastard" "Xiao De, come out here" "Xiao De, come out here" "Xiao De, come out here..." "Alright, stay in touch on the phone" "Brother" "What?" "Had a fight?" "No, Ah Ling fell to her death" "Mrs. Cheung" "What are you doing here?" "I've brought him to Officer Cheung" "Let me in" "Officer Cheung" "Officer Cheung, I'm handing my brother to you" "Officer Cheung, today we are here to give you an explanation" "No more tricks" "I must beat him up today until you ask me to stop" "What?" "Can't do it?" "No, stop beating" "I'll call the police if you don't" "Don't mess with my affairs from now on" "Are you alright?" "I'll take you to a doctor" "Brother Da De..." "What happened?" "Just now a gang came looking for trouble even when I mentioned your name they didn't back down" "Brother Da De, we'll go and find them" "Right" "Da De, where have you been?" "You see our club has been messed up" "We couldn't even find you" "When they came they said they were here to teach you a lesson" "What was I supposed to do?" "Didrt even know who they were?" "Before going they said their big brother was Yi Ching" "Uncle Biu, I'm so sorry about the mess" "I must leave" "Brother Da De" "You're suffering, I'll give you a shot" "No..." "No..." "What happened?" "I'm asking you" "Go away" "What if I don't?" "Don't move" "Don't move" "You two brothers are equally low and mean" "I'm charging you for unlawful possession of weapons causing injury to others" "There's evidence, so you can't deny it" "Our affairs should have all been settled" "Shut up, this is official business" "Da De, someone is here for you" "Hurry and go" "Ninth Uncle, thank you for visiting me" "You asked me to look for Xiao De, but I can't find him" "Don't worry, I'll definitely find him" "You've lost your family because of cocaine" "If he won't take, we'll surround smokehimwithit so that even by smelling, he'll get hooked" "I grew up among drug addicts how come I didn't get hooked?" "Still can't find my little brother?" "He's nowhere to be found" "Ninth uncle, I want to see him, please help" "Get into the car" "Da De, don't you want to see your brother?" "Get into the car quickly" "Officer Cheung, for two?" "You're free today?" "Over here please" "What would you like to drink?" "Later" "Alright" "Where's my brother?" "Be patient, we'll talk about it after this show" "What happened to you?" "Hurry" "Hurry..." "You think I'm cheap, I'll show you how cheap I can be" "Boss, leaving now?" "Come again" "Who are you looking for?" "Where's the one who performed with you?" "That drug addict?" "He's in the washroom" "Xiao De" "Xiao De... what happened to you?" "Xiao De" "Why do you do that?" "Say whatever you want to say" "Xiao De" "Xiao De" "Xiao De" "You can'tjust die like that..." "Xiao De" "You can't die like that, Xiao De" "Xiao De, don't die" "Alright, it's done" "Don't move" "Do you hear me?" "Don't move" "Good, take him back" "Officer Cheung, after months of investigation we found that you abuse your powers for personal revenge" "You tried to get Xiao De hooked" "You know the law and you broke it" "This is something that cannot be tolerated" "I am sorry, I must arrest you now" "Please hand over your pistol and badge" "So you caused the death of my brother" "Be calm" "He will be judged" "Take him back" "Sir, there are dead bodies in the washroom" "Call a car, leave two men behind to finish the job" "Yes" "Take them away" "Go..."

Walking up the narrow doorway, hands shaking not in fear But out of compassion, that I hadn’t felt in years.We had drank and had our laughs,The smile you wore, hell I knew that we have had fun,You told me to hold me, oh so close.Your breath on my neck and my hands in yours,Wishing Id tell you how beautiful, How beautiful you really fucking are.To me.Yeah Me.To Me.Yeah Me.You were such a beauty to me.Carrying you towards a restless night in my arms wishing I had the words to say,That I think I want you to stay…with me.But empty promises, and broken bottles,Put me on my knees,My heart felt so heavy, not yet to be broken,Please dear, don’t do this again.I wish I had the words to say,I wish I had the chance to turn back time,I wish I’d never held you close,But I still wish I’d make you mine.Yes, mine.Seeing you smiling at me.As ruby red tongues gnaw out lies, and deceitIm stuck here kissing your feet,Mistakes were forgiven regrets were now made, the distance felt further than Mars.Phone call wars, are worse on the floor, of a night spent drunk here without you.Without you.Oh without you.Please dear lets start this again.I have my control, and I still love your soul,Im sorry we can’t speak again.Wiping your tears, after beer after beer,We’ll never have those days again, Goodbye.

Low-dose radiation employed in diagnostic imaging causes genetic effects in cultured cells. Exposure to environmental, diagnostic, and occupational sources of radiation frequently involves low doses. Although these doses have no immediately noticeable impact on human health there is great interest in their long-term biological effects. To assess immediate and time-delayed DNA damage in two cell lines exposed to low doses of ionizing radiation by using the comet assay and micronucleus test, and to compare these two techniques in the analysis of low-dose induced genotoxicity. CHO and MRC-5 cells were exposed to 50 milliSievert (mSv) of ionizing radiation and assayed immediately after irradiation and at 16 or 12 passages post-irradiation, respectively. Comet assay and micronucleus test were employed. The comet assay values observed in 50 mSv-treated cells were significantly higher than in the control group for both sample times and cell lines (P < 0.001). Micronuclei frequencies were higher in treated cells than in the control group (P < 0.01, CHO cells passage 16; P < 0.05, MRC-5 cells immediately after exposure; P < 0.01 MRC-5 cells passage 12). Correlation analysis between the two techniques was statistically significant (correlation coefficient 0.82, P < 0.05 and correlation coefficient 0.86, P < 0.05 for CHO and MRC-5 cells, respectively). Cells scored at passages 12 or 16 showed more damage than those scored immediately after exposure in both cell lines (no statistically significant differences). Cytomolecular and cytogenetic damage was observed in cells exposed to very low doses of X-rays and their progeny. A single low dose of ionizing radiation was sufficient to induce such response, indicating that mammalian cells are exquisitely sensitive to it. Comet and micronucleus assays are sensitive enough to assess this damage, although the former seems to be more efficient.

DESCRIPTION: (Applicant's Abstract) Methamphetarnine abuse in conjunction with sexual activity is now epidemic among homosexual and bisexual males. We propose an investigation of the efficacy of two promising putative stimulant abuse pharmacotherapies, desipramine and sertraline, as abstinence facilitation treatments for metharnphetamine (MAMPH) dependence in a sample of homosexual and bisexual males with symptomatic AIDS. The pharmacotherapies will be applied as adjunctive treatment linked to a medical care clinic for AIDS. The investigation will employ a placebo controlled, double-blind, random assignment, three cell parallel group design that will assess 120 subjects during 12 week's of experimental treatment, with follow-up at 1, 3 and 6 months. We hypothesize that subjects on active desipramine or sertraline, but not placebo, will evidence: 1. Decreased MAMPH abuse severity, operationalized as a decrease in MAMPH use on quantitative GCMS in urine and on self-reported amounts and frequency of use, as increased control over MAMPH craving and as increased durations of abstinence and retention in drug treatment. 2. Increased utilization of medical services for AIDS, operationalized as increases on measures of engagement attendance, and compliance with prescribed domains of AIDS medical care. 3. Decreased frequency of high risk sexual behaviors and of drug use in conjunction with sexual activity operationalized as decreases in self-reports of unsafe sexual behaviors and concurrent drug use on sexual behavior assessments.