Datasets:

gabrielaltay

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pubtator-central-bigbio-kb-2022-12-18

like 0

[ { "id": "15169216_title", "type": "title", "text": [ "Weakened constraints from b-->sgamma on supersymmetry flavor mixing due to next-to-leading-order corrections." ], "offsets": [ [ 0, 109 ] ] }, { "id": "15169216_abstract", "type": "abstract", "text": [ "We examine the process B-->X(s)gamma in minimal supersymmetry (SUSY) with general squark flavor mix-ings. We include all relevant next-to-leading order (NLO) QCD corrections and dominant NLO SUSY effects from the gluino. We find that gluino-squark corrections to down-type quark masses induce large NLO corrections to the dominant Wilson coefficients whose size is often similar to those at LO, es-pecially at large tan(beta. For micro>0, destructive interference and suppression by the renormalization group running lead to a \"focusing effect\" of reducing the size of gluino corrections to the branching ratio, and also of reducing the LO sensitivity to flavor mixings among squarks. Constraints from B(B-->X(s)gamma) on the SUSY-breaking scale can become significantly weakened relative to the minimal flavor violation case, even, at large tan(beta, for small flavor mixings. The case of micro<0 also becomes allowed." ], "offsets": [ [ 110, 1029 ] ] } ]

[ { "id": "15169216_-_0", "type": "Chemical", "text": [ "gluino" ], "offsets": [ [ 323, 329 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "32142647_title", "type": "title", "text": [ "A Plug-and-Latch Mechanism for Gating the Mechanosensitive Piezo Channel." ], "offsets": [ [ 0, 73 ] ] }, { "id": "32142647_abstract", "type": "abstract", "text": [ "The mechanosensitive Piezo1 and Piezo2 channels convert mechanical force into cation permeation. However, their precise mechanogating and regulatory mechanisms remain elusive. Here, we report that Piezo1 utilizes three lateral ion-conducting portals equipped with physical gates for cooperative gating and splicing regulation. Mutating residues lining the portal converts Piezo1 into an anion-selective channel, demonstrating the portal-based cation-permeating pathway. Intriguingly, the portal is physically blocked with a plug domain, which undergoes alternative splicing in both Piezo1 and Piezo2. The Piezo1 isoform has local openings of the portals, enlarged single-channel conductance and sensitized mechanosensitivity. Remarkably, the three plugs are strategically latched onto the central axis for coordinated gating of the three portals. Disrupting the latching induces three quantal sub-conductance states in Piezo1, but not in the isoform. Together, we propose that Piezo utilizes an elegant plug-and-latch mechanism to physically and coordinately gate the lateral portals through the spliceable plug gates." ], "offsets": [ [ 74, 1192 ] ] } ]

[ { "id": "32142647_9780_0", "type": "Gene", "text": [ "Piezo1" ], "offsets": [ [ 95, 101 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "9780" } ] }, { "id": "32142647_63895_1", "type": "Gene", "text": [ "Piezo2" ], "offsets": [ [ 106, 112 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "63895" } ] }, { "id": "32142647_9780_2", "type": "Gene", "text": [ "Piezo1" ], "offsets": [ [ 271, 277 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "9780" } ] }, { "id": "32142647_9780_3", "type": "Gene", "text": [ "Piezo1" ], "offsets": [ [ 446, 452 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "9780" } ] }, { "id": "32142647_9780_4", "type": "Gene", "text": [ "Piezo1" ], "offsets": [ [ 656, 662 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "9780" } ] }, { "id": "32142647_63895_5", "type": "Gene", "text": [ "Piezo2" ], "offsets": [ [ 667, 673 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "63895" } ] }, { "id": "32142647_9780_6", "type": "Gene", "text": [ "Piezo1" ], "offsets": [ [ 679, 685 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "9780" } ] }, { "id": "32142647_9780_7", "type": "Gene", "text": [ "Piezo1" ], "offsets": [ [ 993, 999 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "9780" } ] } ]

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[ { "id": "32658225_title", "type": "title", "text": [ "Structural diversification of bola-amphiphilic glycolipid-type supramolecular hydrogelators exhibiting colour changes along with the gel-sol transition." ], "offsets": [ [ 0, 152 ] ] }, { "id": "32658225_abstract", "type": "abstract", "text": [ "We diversified the structures of bola-amphiphilic glycolipid-type supramolecular hydrogelators that exhibited reversible thermochromism along with a gel-sol transition. The hydrogelators were designed and synthesized to have homo- or hetero-saccharides on each end of their molecules. Herein, the effects of the saccharides' structure on the gelation ability are discussed." ], "offsets": [ [ 153, 526 ] ] } ]

[ { "id": "32658225_-_0", "type": "Chemical", "text": [ "homo- or hetero-saccharides" ], "offsets": [ [ 378, 405 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "10883804_title", "type": "title", "text": [ "Relation of Fos-IR expression in the pelvic ganglion to sexual behavior in laboratory rats." ], "offsets": [ [ 0, 91 ] ] }, { "id": "10883804_abstract", "type": "abstract", "text": [ "The pelvic ganglion (PG) provides both sympathetic and parasympathetic innervation to the genitalia and other pelvic structures. To determine whether neuronal activity; of the PG, as detected by Fos-like immunoreactivity (Fos-IR), is related to sexual stimulation, male and female rats were tested under a variety of conditions. In males, Fos-IR expression in the PG was positively correlated with the amount of both genital and noncontact stimulation. In females, only ejaculation preceded by multiple intromissions induced a significant increase in Fos-IR; multiple intromissions or ejaculation preceded by only 0-1 intromission did not affect Fos-IR. Additional experiments comparing Fos-IR expression, in which some females were allowed to pace their sexual contact and others were not, revealed that ejaculation duration was the key factor in the induction of Fos-IR in female rats. Because the conditions under which Fos-IR expression occurred in females are identical to those required for sperm transport, we suggest that, in the female, sperm transport is regulated in part by autonomic outflow from the PG after copulation. These relations between sexual behavior and measures of PG activity are consistent with the idea that the sexually dimorphic organization of the peripheral nervous system plays a major role in mediating the gender-specific outcome of copulation: ejaculation in the male and sperm transport in the female." ], "offsets": [ [ 92, 1530 ] ] } ]

[ { "id": "10883804_314322_0", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 12, 15 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_10116_1", "type": "Species", "text": [ "laboratory rats" ], "offsets": [ [ 75, 90 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "10883804_-_2", "type": "Chemical", "text": [ "PG" ], "offsets": [ [ 268, 270 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "10883804_314322_3", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 287, 290 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_314322_4", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 314, 317 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_10116_5", "type": "Species", "text": [ "rats" ], "offsets": [ [ 373, 377 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "10883804_314322_6", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 431, 434 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_314322_7", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 643, 646 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_314322_8", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 738, 741 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_314322_9", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 779, 782 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_314322_10", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 957, 960 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_10116_11", "type": "Species", "text": [ "rats" ], "offsets": [ [ 974, 978 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "10883804_314322_12", "type": "Gene", "text": [ "Fos" ], "offsets": [ [ 1015, 1018 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "314322" } ] }, { "id": "10883804_-_13", "type": "Chemical", "text": [ "PG" ], "offsets": [ [ 1205, 1207 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "35454025_title", "type": "title", "text": [ "Prognostic Factors for Recurrence in Pituitary Adenomas: Recent Progress and Future Directions." ], "offsets": [ [ 0, 95 ] ] }, { "id": "35454025_abstract", "type": "abstract", "text": [ "Pituitary adenomas (PAs) are benign lesions; nonetheless, some PAs exhibit aggressive behaviors, which lead to recurrence. The impact of pituitary dysfunction, invasion-related risks, and other complications considerably affect the quality of life of patients with recurrent PAs. Reliable prognostic factors are needed for recurrent PAs but require confirmation. This review summarizes research progress on two aspects-namely, the clinical and biological factors (biomarkers) for recurrent PAs. Postoperative residue, age, immunohistological subtypes, invasion, tumor size, hormone levels, and postoperative radiotherapy can predict the risk of recurrence in patients with PAs. Additionally, biomarkers such as Ki-67, p53, cadherin, pituitary tumor transforming gene, matrix metalloproteinase-9, epidermal growth factor receptor, fascin actin-bundling protein 1, cyclooxygenase-2, and some miRNAs and lncRNAs may be utilized as valuable tools for predicting PA recurrence. As no single marker can independently predict PA recurrence, we introduce an array of comprehensive models and grading methods, including multiple prognostic factors, to predict the prognosis of PAs, which have shown good effectiveness and would be beneficial for predicting PA recurrence." ], "offsets": [ [ 96, 1358 ] ] } ]

[ { "id": "35454025_MESH:D010911_0", "type": "Disease", "text": [ "Pituitary Adenomas" ], "offsets": [ [ 37, 55 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010911" } ] }, { "id": "35454025_MESH:D010911_1", "type": "Disease", "text": [ "Pituitary adenomas" ], "offsets": [ [ 96, 114 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010911" } ] }, { "id": "35454025_MESH:D001523_2", "type": "Disease", "text": [ "PAs exhibit aggressive behaviors" ], "offsets": [ [ 159, 191 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001523" } ] }, { "id": "35454025_MESH:D010900_3", "type": "Disease", "text": [ "pituitary dysfunction" ], "offsets": [ [ 233, 254 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010900" } ] }, { "id": "35454025_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 347, 355 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35454025_MESH:D009369_5", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 658, 663 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "35454025_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 755, 763 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35454025_7157_7", "type": "Gene", "text": [ "p53" ], "offsets": [ [ 814, 817 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "7157" } ] }, { "id": "35454025_MESH:D010911_8", "type": "Disease", "text": [ "pituitary tumor" ], "offsets": [ [ 829, 844 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010911" } ] }, { "id": "35454025_4318_9", "type": "Gene", "text": [ "matrix metalloproteinase-9" ], "offsets": [ [ 864, 890 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "4318" } ] }, { "id": "35454025_1956_10", "type": "Gene", "text": [ "epidermal growth factor receptor" ], "offsets": [ [ 892, 924 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1956" } ] }, { "id": "35454025_6624_11", "type": "Gene", "text": [ "fascin actin-bundling protein 1" ], "offsets": [ [ 926, 957 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "6624" } ] }, { "id": "35454025_5743_12", "type": "Gene", "text": [ "cyclooxygenase-2" ], "offsets": [ [ 959, 975 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5743" } ] } ]

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[ { "id": "10393562_title", "type": "title", "text": [ "Significance of controlling crystallization mechanisms and kinetics in pharmaceutical systems." ], "offsets": [ [ 0, 94 ] ] }, { "id": "10393562_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 95, 95 ] ] } ]

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[ { "id": "19720365_title", "type": "title", "text": [ "Randomized, double-blind, placebo-controlled trial to evaluate the safety and immunogenicity of live oral cholera vaccine 638 in Cuban adults." ], "offsets": [ [ 0, 142 ] ] }, { "id": "19720365_abstract", "type": "abstract", "text": [ "A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the safety, reactogenicity and the immunogenicity of a 2 x 10(9)CFU dose of the 638 lyophilized live attenuated cholera vaccine for oral administration, formulated and produced at Finlay Institute, City of Havana, Cuba. Thirty-six healthy female and male adult volunteers from 18 to 40 years old were involved, clinically examined and laboratory tested after the informed consent signature. Adverse events were monitored and seroconversion rates and geometrical mean titer (GMT) of vibriocidal antibodies were tested in volunteer's sera samples. Neither serious adverse events nor other damages to the volunteers due to vaccine or placebo feeding were reported during the clinical follow-up period of this study; none of the adverse events registered within the first 72 h after inoculation were life-threatening for volunteers. Neither severe nor moderate adverse events were reported. Sixty-one percent of subjects showed mild expected adverse events in an interval lower than 24h up to the first 72 h, 75% of these in the vaccinated group and 18% in the placebo group. Fourteen days after inoculation the GMT of vibriocidal antibodies in the vaccine group significantly increased in comparison to the placebo group. All subjects in the vaccine group (24) seroconverted (100%). Results show that this vaccine is safe, well tolerated and immunogenic in healthy female and male volunteers." ], "offsets": [ [ 143, 1620 ] ] } ]

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[ { "id": "29906370_title", "type": "title", "text": [ "The Incidence, Characteristics and Outcomes of Pneumothorax in Thai Surgical Intensive Care Units (Thai-SICU Study)." ], "offsets": [ [ 0, 116 ] ] }, { "id": "29906370_abstract", "type": "abstract", "text": [ "Objective: To identify incidence, characteristics, and outcomes of pneumothorax among patients who specifically stayed in surgical intensive care units (SICUs). Material and Method: This was a multicenter prospective cohort study conducted in 9 University-affiliated SICUs inThailand. Incidence of pneumothorax and its outcomes were evaluated from April 2011 to January 2013. Results: 4,652 patients who were admitted to SICU were enrolled. The incidence of pneumothorax was 0.5% (25 cases) in our study. Significant characteristics were found in the pneumothorax group, including: lower BMI, underlying malignancy and COPD, higher APACHE-II and SOFA score within 24 hours of first ICU admission, pulmonary infiltration pattern of chest imaging and usage of mechanical ventilation. In terms of outcome, there were higher SICU mortality and 28-day hospital mortality in pneumothorax than non-pneumothorax patients at 28.0% vs. 9.6%, p = 0.002 and at 44.0% vs. 13.6%, p<0.001, respectively. Conclusion: Patients admitted to surgical intensive care units who developed pneumothorax had higher risk of intensive care unit mortality and 28-day hospital mortality than non-pneumothorax patients, as well as a longer intensive care unit and hospital length of stays." ], "offsets": [ [ 117, 1376 ] ] } ]

[ { "id": "29906370_MESH:D011030_0", "type": "Disease", "text": [ "Pneumothorax" ], "offsets": [ [ 47, 59 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_MESH:D011030_1", "type": "Disease", "text": [ "pneumothorax" ], "offsets": [ [ 184, 196 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 203, 211 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29906370_MESH:D011030_3", "type": "Disease", "text": [ "pneumothorax" ], "offsets": [ [ 415, 427 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 508, 516 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29906370_MESH:D011030_5", "type": "Disease", "text": [ "pneumothorax" ], "offsets": [ [ 575, 587 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_MESH:D011030_6", "type": "Disease", "text": [ "pneumothorax" ], "offsets": [ [ 668, 680 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_MESH:D009369_7", "type": "Disease", "text": [ "malignancy" ], "offsets": [ [ 721, 731 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "29906370_MESH:D029424_8", "type": "Disease", "text": [ "COPD" ], "offsets": [ [ 736, 740 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D029424" } ] }, { "id": "29906370_MESH:D003643_9", "type": "Disease", "text": [ "mortality" ], "offsets": [ [ 943, 952 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "29906370_MESH:D003643_10", "type": "Disease", "text": [ "mortality" ], "offsets": [ [ 973, 982 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "29906370_MESH:D011030_11", "type": "Disease", "text": [ "pneumothorax" ], "offsets": [ [ 986, 998 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_MESH:D011030_12", "type": "Disease", "text": [ "pneumothorax" ], "offsets": [ [ 1008, 1020 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_9606_13", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1021, 1029 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29906370_9606_14", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 1118, 1126 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29906370_MESH:D011030_15", "type": "Disease", "text": [ "pneumothorax" ], "offsets": [ [ 1183, 1195 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_MESH:D003643_16", "type": "Disease", "text": [ "mortality" ], "offsets": [ [ 1235, 1244 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "29906370_MESH:D003643_17", "type": "Disease", "text": [ "mortality" ], "offsets": [ [ 1265, 1274 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "29906370_MESH:D011030_18", "type": "Disease", "text": [ "pneumothorax" ], "offsets": [ [ 1284, 1296 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011030" } ] }, { "id": "29906370_9606_19", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1297, 1305 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "26633911_title", "type": "title", "text": [ "Social Movements, Organizations, and Fields: a Decade of Theoretical Integration." ], "offsets": [ [ 0, 81 ] ] }, { "id": "26633911_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 82, 82 ] ] } ]

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[ { "id": "15268331_title", "type": "title", "text": [ "Interfacial tension and wetting in colloid-polymer mixtures." ], "offsets": [ [ 0, 60 ] ] }, { "id": "15268331_abstract", "type": "abstract", "text": [ "We calculate the interfacial tension and the wetting behavior in phase separated colloid-polymer mixtures both for ideal and excluded volume interacting polymers. Within the recently developed extension of the free volume theory to include polymer interactions the interfacial tension of the free interface is calculated by adding a van der Waals squared gradient term. The wetting behavior at a hard wall is calculated following a Cahn-Fisher-Nakanishi approach taking the one- and two-body colloid-wall interactions into account. Comparing results for interacting polymers with those for ideal polymers we find that for interacting polymers the interfacial tension does not increase as steeply as a function of the gas-liquid colloid density difference. Furthermore, the wetting transition shifts to higher polymer concentrations, even to above the triple line. The predictions for both the interfacial tension and the wetting are compared to recent experiments." ], "offsets": [ [ 61, 1025 ] ] } ]

[ { "id": "15268331_MESH:D011108_0", "type": "Chemical", "text": [ "polymer" ], "offsets": [ [ 43, 50 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011108" } ] }, { "id": "15268331_MESH:D011108_1", "type": "Chemical", "text": [ "polymer" ], "offsets": [ [ 150, 157 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011108" } ] }, { "id": "15268331_MESH:D011108_2", "type": "Chemical", "text": [ "polymers" ], "offsets": [ [ 214, 222 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011108" } ] }, { "id": "15268331_MESH:D011108_3", "type": "Chemical", "text": [ "polymer" ], "offsets": [ [ 301, 308 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011108" } ] }, { "id": "15268331_MESH:D011108_4", "type": "Chemical", "text": [ "polymers" ], "offsets": [ [ 627, 635 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011108" } ] }, { "id": "15268331_MESH:D011108_5", "type": "Chemical", "text": [ "polymers" ], "offsets": [ [ 657, 665 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011108" } ] }, { "id": "15268331_MESH:D011108_6", "type": "Chemical", "text": [ "polymers" ], "offsets": [ [ 695, 703 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011108" } ] }, { "id": "15268331_MESH:D011108_7", "type": "Chemical", "text": [ "polymer" ], "offsets": [ [ 870, 877 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011108" } ] } ]

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[ { "id": "9176296_title", "type": "title", "text": [ "Role of endogenous centrally released NO in cardiovascular adaptation to hypovolemia in WKY and SHR." ], "offsets": [ [ 0, 100 ] ] }, { "id": "9176296_abstract", "type": "abstract", "text": [ "The role of endogenous centrally released nitric oxide (NO) during hypovolemia was investigated in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). Bleeding of the rats (1.3% of blood volume) was performed after intracerebroventricular (ICV) administration of: 1) artificial cerebrospinal fluid (series 1, time control, 8 WKY and 8 SHR); 2) 0.5 mg NG-nitro-L-arginine (L-NNA, 2.3 nmol), an inhibitor of NO synthesis (series 2, 8 WKY and 7 SHR); and 3) 0.5 mg L-NNA followed by 1 mg (5.8 nmol) of L-arginine (L-Arg) (6 WKY and 5 SHR). In WKY, hypotension was associated with significant bradycardia (P < 0.001), whereas in SHR slight acceleration of heart rate was observed. In series 2 hemorrhage resulted in a small but significant increase of mean arterial pressure (MAP; P < 0.05) and considerable tachycardia (P < 0.001). In SHR, L-NNA did not modify the decrease of MAP during hypovolomia, and bleeding resulted in a significant bradycardia (P < 0.001). Pretreatment with L-Arg in series 3 was able to reverse the effects of L-NNA on changes of MAP and heart rate during hypovolemia. The results indicate that the central nitroxidergic system plays a significant role in eliciting hypotension and bradycardia in normotensive WKY during hemorrhage. Function of the central nitroxidergic system is significantly altered in SHR in which NO appears to prevent hemorrhagic bradycardia and to reduce the hypotensive effect." ], "offsets": [ [ 101, 1549 ] ] } ]

[ { "id": "9176296_MESH:D020896_0", "type": "Disease", "text": [ "hypovolemia" ], "offsets": [ [ 73, 84 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020896" } ] }, { "id": "9176296_MESH:D009569_1", "type": "Chemical", "text": [ "nitric oxide" ], "offsets": [ [ 143, 155 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009569" } ] }, { "id": "9176296_MESH:D020896_2", "type": "Disease", "text": [ "hypovolemia" ], "offsets": [ [ 168, 179 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020896" } ] }, { "id": "9176296_MESH:D006973_3", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 250, 262 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "9176296_10116_4", "type": "Species", "text": [ "rats" ], "offsets": [ [ 263, 267 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "9176296_10116_5", "type": "Species", "text": [ "rats" ], "offsets": [ [ 291, 295 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "9176296_MESH:D007022_6", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 669, 680 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007022" } ] }, { "id": "9176296_MESH:D001919_7", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 713, 724 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001919" } ] }, { "id": "9176296_MESH:D006470_8", "type": "Disease", "text": [ "hemorrhage" ], "offsets": [ [ 813, 823 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006470" } ] }, { "id": "9176296_MESH:D013610_9", "type": "Disease", "text": [ "tachycardia" ], "offsets": [ [ 928, 939 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013610" } ] }, { "id": "9176296_MESH:D019335_10", "type": "Chemical", "text": [ "L-NNA" ], "offsets": [ [ 961, 966 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019335" } ] }, { "id": "9176296_MESH:D006470_11", "type": "Disease", "text": [ "bleeding" ], "offsets": [ [ 1026, 1034 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006470" } ] }, { "id": "9176296_MESH:D001919_12", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 1061, 1072 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001919" } ] }, { "id": "9176296_MESH:D001120_13", "type": "Chemical", "text": [ "L-Arg" ], "offsets": [ [ 1104, 1109 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001120" } ] }, { "id": "9176296_MESH:D019335_14", "type": "Chemical", "text": [ "L-NNA" ], "offsets": [ [ 1157, 1162 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019335" } ] }, { "id": "9176296_MESH:D020896_15", "type": "Disease", "text": [ "hypovolemia" ], "offsets": [ [ 1203, 1214 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020896" } ] }, { "id": "9176296_MESH:D007022_16", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 1313, 1324 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007022" } ] }, { "id": "9176296_MESH:D001919_17", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 1329, 1340 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001919" } ] }, { "id": "9176296_MESH:D006470_18", "type": "Disease", "text": [ "hemorrhage" ], "offsets": [ [ 1368, 1378 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006470" } ] }, { "id": "9176296_MESH:D001919_19", "type": "Disease", "text": [ "hemorrhagic bradycardia" ], "offsets": [ [ 1488, 1511 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001919" } ] }, { "id": "9176296_MESH:D007022_20", "type": "Disease", "text": [ "hypotensive" ], "offsets": [ [ 1530, 1541 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007022" } ] } ]

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[ { "id": "11596996_title", "type": "title", "text": [ "Future perspectives for Tay-Sachs disease." ], "offsets": [ [ 0, 42 ] ] }, { "id": "11596996_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 43, 43 ] ] } ]

[ { "id": "11596996_MESH:D013661_0", "type": "Disease", "text": [ "Tay-Sachs disease" ], "offsets": [ [ 24, 41 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013661" } ] } ]

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[ { "id": "6467671_title", "type": "title", "text": [ "Manifestations and natural history of idiopathic hemihypertrophy: a review of eleven cases." ], "offsets": [ [ 0, 91 ] ] }, { "id": "6467671_abstract", "type": "abstract", "text": [ "Idiopathic hemihypertrophy is a specific entity which is distinct from the numerous other causes of limb overgrowth. In our investigation of eleven new cases in South Africa and Australia, no genetic or other aetiological factors could be recognised. There were no differences in bone age between the normal and hypertrophied limbs and the pattern of growth through life showed that relative body proportions remained the same. Idiopathic hemihypertrophy is associated with mild mental retardation, genito-urinary anomalies and an oncogenic potential. Regular clinical surveillance for abdominal tumours is recommended." ], "offsets": [ [ 92, 711 ] ] } ]

[ { "id": "6467671_MESH:C563014_0", "type": "Disease", "text": [ "idiopathic hemihypertrophy" ], "offsets": [ [ 38, 64 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C563014" } ] }, { "id": "6467671_MESH:C563014_1", "type": "Disease", "text": [ "Idiopathic hemihypertrophy" ], "offsets": [ [ 92, 118 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C563014" } ] }, { "id": "6467671_MESH:D019214_2", "type": "Disease", "text": [ "limb overgrowth" ], "offsets": [ [ 192, 207 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019214" } ] }, { "id": "6467671_MESH:D006984_3", "type": "Disease", "text": [ "hypertrophied" ], "offsets": [ [ 404, 417 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006984" } ] }, { "id": "6467671_MESH:C563014_4", "type": "Disease", "text": [ "Idiopathic hemihypertrophy" ], "offsets": [ [ 520, 546 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C563014" } ] }, { "id": "6467671_MESH:D008607_5", "type": "Disease", "text": [ "mental retardation" ], "offsets": [ [ 571, 589 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008607" } ] }, { "id": "6467671_MESH:D014565_6", "type": "Disease", "text": [ "genito-urinary anomalies" ], "offsets": [ [ 591, 615 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014565" } ] }, { "id": "6467671_MESH:D000008_7", "type": "Disease", "text": [ "abdominal tumours" ], "offsets": [ [ 678, 695 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000008" } ] } ]

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[ { "id": "33020217_title", "type": "title", "text": [ "Revaluing the Role of vmPFC in the Acquisition of Pavlovian Threat Conditioning in Humans." ], "offsets": [ [ 0, 90 ] ] }, { "id": "33020217_abstract", "type": "abstract", "text": [ "The role of the ventromedial prefrontal cortex (vmPFC) in human pavlovian threat conditioning has been relegated largely to the extinction or reversal of previously acquired stimulus-outcome associations. However, recent neuroimaging evidence questions this view by also showing activity in the vmPFC during threat acquisition. Here we investigate the casual role of vmPFC in the acquisition of pavlovian threat conditioning by assessing skin conductance response (SCR) and declarative memory of stimulus-outcome contingencies during a differential pavlovian threat-conditioning paradigm in eight patients with a bilateral vmPFC lesion, 10 with a lesion outside PFC and 10 healthy participants (each group included both females and males). Results showed that patients with vmPFC lesion failed to produce a conditioned SCR during threat acquisition, despite no evidence of compromised SCR to unconditioned stimulus or compromised declarative memory for stimulus-outcome contingencies. These results suggest that the vmPFC plays a causal role in the acquisition of new learning and not just in the extinction or reversal of previously acquired learning, as previously thought. Given the role of the vmPFC in schema-related processing and latent structure learning, the vmPFC may be required to construct a detailed representation of the task, which is needed to produce a sustained conditioned physiological response in anticipation of the unconditioned stimulus during threat acquisition.SIGNIFICANCE STATEMENT Pavlovian threat conditioning is an adaptive mechanism through which organisms learn to avoid potential threats, thus increasing their chances of survival. Understanding what brain regions contribute to such a process is crucial to understand the mechanisms underlying adaptive as well as maladaptive learning, and has the potential to inform the treatment of anxiety disorders. Importantly, the role of the ventromedial prefrontal cortex (vmPFC) in the acquisition of pavlovian threat conditioning has been relegated largely to the inhibition of previously acquired learning. Here, we show that the vmPFC actually plays a causal role in the acquisition of pavlovian threat conditioning." ], "offsets": [ [ 91, 2289 ] ] } ]

[ { "id": "33020217_9606_0", "type": "Species", "text": [ "Humans" ], "offsets": [ [ 83, 89 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "33020217_9606_1", "type": "Species", "text": [ "human" ], "offsets": [ [ 149, 154 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "33020217_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 688, 696 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "33020217_9606_3", "type": "Species", "text": [ "participants" ], "offsets": [ [ 772, 784 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "33020217_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 851, 859 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "33020217_MESH:D007859_5", "type": "Disease", "text": [ "maladaptive learning" ], "offsets": [ [ 1891, 1911 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007859" } ] }, { "id": "33020217_MESH:D001007_6", "type": "Disease", "text": [ "anxiety disorders" ], "offsets": [ [ 1962, 1979 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001007" } ] } ]

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[ { "id": "23600952_title", "type": "title", "text": [ "Invasive carcinoma with acinic cell-like features of the breast." ], "offsets": [ [ 0, 64 ] ] }, { "id": "23600952_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 65, 65 ] ] } ]

[ { "id": "23600952_MESH:D009361_0", "type": "Disease", "text": [ "Invasive carcinoma" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009361" } ] } ]

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[ { "id": "12570206_title", "type": "title", "text": [ "Development and validation of a multiplexed Y-chromosome STR genotyping system, Y-PLEX 6, for forensic casework." ], "offsets": [ [ 0, 112 ] ] }, { "id": "12570206_abstract", "type": "abstract", "text": [ "A Y-chromosome multiplex polymerase chain reaction (PCR) amplification kit, known as Y-PLEX 6, has been developed for use in human identification. The Y-PLEX 6 kit enables simultaneous amplification of six polymorphic short tandem repeat (STR) loci located on the non-recombinant region of the human Y-chromosome. These loci are: DYS393, DYS19, DYS38911, DYS390, DYS391, and DYS385. Our studies show that as little as 0.2 ng of template DNA can be used for analysis. The specificity of the amplification reaction enabled analysis of male DNA in a male:female DNA mixture at a ratio of 1:125. Among the six Y-STR loci, the maximum mean stutter percentage was 11.9 for allele at DYS38911 locus. Attempts at amplification of DNA from various animal sources revealed that the Y-PLEX 6 primers are human specific. Details of the development of the kit, generation and description of the allelic ladders, and validation of the multiplex PCR are presented. In addition, Y-STR allele and haplotype frequencies in three populations have been investigated. The data indicate that results obtained using the Y-PLEX 6 kit are robust, sensitive, and reliable and can be used in human forensic and male lineage identification cases." ], "offsets": [ [ 113, 1331 ] ] } ]

[ { "id": "12570206_9606_0", "type": "Species", "text": [ "human" ], "offsets": [ [ 238, 243 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12570206_9606_1", "type": "Species", "text": [ "human" ], "offsets": [ [ 407, 412 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12570206_-_2", "type": "Chemical", "text": [ "DYS393" ], "offsets": [ [ 443, 449 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "12570206_-_3", "type": "Chemical", "text": [ "DYS19" ], "offsets": [ [ 451, 456 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "12570206_-_4", "type": "Chemical", "text": [ "DYS38911" ], "offsets": [ [ 458, 466 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "12570206_-_5", "type": "Chemical", "text": [ "DYS390" ], "offsets": [ [ 468, 474 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "12570206_-_6", "type": "Chemical", "text": [ "DYS391" ], "offsets": [ [ 476, 482 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "12570206_-_7", "type": "Chemical", "text": [ "DYS385" ], "offsets": [ [ 488, 494 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "12570206_9606_8", "type": "Species", "text": [ "human" ], "offsets": [ [ 906, 911 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12570206_9606_9", "type": "Species", "text": [ "human" ], "offsets": [ [ 1278, 1283 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "12124750_title", "type": "title", "text": [ "A new look at an old visual system: structure and development of the compound eyes and optic ganglia of the brine shrimp Artemia salina Linnaeus, 1758 (Branchiopoda, anostraca)." ], "offsets": [ [ 0, 177 ] ] }, { "id": "12124750_abstract", "type": "abstract", "text": [ "Compared to research carried out on decapod crustaceans, the development of the visual system in representatives of the entomostracan crustaceans is poorly understood. However, the structural evolution of the arthropod visual system is an important topic in the new debate on arthropod relationships, and entomostracan crustaceans play a key role in this discussion. Hence, data on structure and ontogeny of the entomostracan visual system are likely to contribute new aspects to our understanding of arthropod phylogeny. Therefore, we explored the proliferation of neuronal stem cells (in vivo incorporation of bromodeoxyuridine) and the developmental expression of synaptic proteins (immunohistochemistry against synapsins) in the developing optic neuropils of the brine shrimp Artemia salina Linnaeus, 1758 (Crustacea, Entomostraca, Branchiopoda, Anostraca) from hatching to adulthood. The morphology of the adult visual system was examined in serial sections of plastic embedded specimens. Our results indicate that the cellular material that gives rise to the visual system (compound eyes and two optic ganglia) is contributed by the mitotic activity of neuronal stem cells that are arranged in three band-shaped proliferation zones. Synapsin-like immunoreactivity in the lamina ganglionaris and the medulla externa initiated only after the anlagen of the compound eyes had already formed, suggesting that the emergence of the two optic neuropils lags behind the proliferative action of these stem cells. Neurogenesis in A. salina is compared to similar processes in malacostracan crustaceans and possible phylogenetic implications are discussed." ], "offsets": [ [ 178, 1829 ] ] } ]

[ { "id": "12124750_MESH:D001973_0", "type": "Chemical", "text": [ "bromodeoxyuridine" ], "offsets": [ [ 790, 807 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001973" } ] }, { "id": "12124750_85549_1", "type": "Species", "text": [ "A. salina" ], "offsets": [ [ 1704, 1713 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "85549" } ] } ]

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[ { "id": "23789497_title", "type": "title", "text": [ "[Management of hypertension recorded as at least 180/110 mmHg]." ], "offsets": [ [ 0, 63 ] ] }, { "id": "23789497_abstract", "type": "abstract", "text": [ "Stage 3 hypertension (severe) is far from rare. It may be part of a previous hypertension condition which is difficult to control, or occur more acutely, in which case it will be harder for the patient to bear. When it is symptomatic and a fortiorione or more organs targeted by hypertension are affected, management must be fast and appropriate. It may take the form of a hypertensive urgency, in which case the investigations and treatment usually take place in outpatients, with oral treatment. it may also be a hypertensive emergency for which treatment involves hospitalization in an intensive care unit with intravenous anti-hypertensive treatment. A reduction in blood pressure must be obtained rapidly but not suddenly; it must be more or less significant depending on the clinical situation, and also progressive." ], "offsets": [ [ 64, 886 ] ] } ]

[ { "id": "23789497_MESH:D006973_0", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 15, 27 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "23789497_MESH:D006973_1", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 72, 84 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "23789497_MESH:D006973_2", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 141, 153 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "23789497_9606_3", "type": "Species", "text": [ "patient" ], "offsets": [ [ 258, 265 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "23789497_MESH:D006973_4", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 343, 355 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "23789497_MESH:D006973_5", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 437, 449 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "23789497_MESH:D006973_6", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 579, 591 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "23789497_MESH:D006973_7", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 695, 707 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] } ]

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[ { "id": "31797564_title", "type": "title", "text": [ "Barriers to use of radial access for percutaneous coronary intervention." ], "offsets": [ [ 0, 72 ] ] }, { "id": "31797564_abstract", "type": "abstract", "text": [ "OBJECTIVES: The aim of this study was to identify barriers to transradial access percutaneous coronary intervention (PCI). BACKGROUND: Transradial access yields fewer vascular complications, earlier ambulation, and more patient comfort. However, the adoption to practice is slow, and transfemoral access is still commonly used. METHODS: We identified all PCIs done by one operator in a radial-first trainee-driven practice. The individual charts were reviewed for all PCIs using femoral access. Reasons for not using radial access were identified. Descriptive statistics were used to report reasons for not using transradial access. Analyses were performed on a per-procedure basis. RESULTS: Of 1,948 PCIs, 1,790 (92%) were via radial access and 158 (8%) via femoral access. Femoral access was used to bail out unsuccessful radial access in 21 PCIs (13% of all femoral PCIs, 1% of all PCIs). Radial access was unsuccessful due to failure to cannulate radial artery, radial artery spasm, and radial loop in majority of radial access failure PCIs (n = 13). Femoral access was used as a primary strategy in 137 PCIs (87% of all femoral PCIs, 7% of all PCIs), mostly due to undetectable radial artery pulse (both left and right) (n = 40). CONCLUSIONS: Radial access can be used for PCI safely and effectively. Inadequate radial pulse is the main barrier. Adjunctive strategies such as ulnar access and use of ultrasound may further increase the success rate of arterial access from the upper extremities." ], "offsets": [ [ 73, 1573 ] ] } ]

[ { "id": "31797564_9606_0", "type": "Species", "text": [ "patient" ], "offsets": [ [ 293, 300 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "31797564_MESH:D020301_1", "type": "Disease", "text": [ "radial artery spasm" ], "offsets": [ [ 1039, 1058 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020301" } ] }, { "id": "31797564_MESH:D006333_2", "type": "Disease", "text": [ "radial access failure PCIs" ], "offsets": [ [ 1091, 1117 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006333" } ] } ]

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[ { "id": "6465645_title", "type": "title", "text": [ "Effect of time on regional organ perfusion during two methods of cardiopulmonary resuscitation." ], "offsets": [ [ 0, 95 ] ] }, { "id": "6465645_abstract", "type": "abstract", "text": [ "The effect of the duration of cardiopulmonary resuscitation (CPR) on capillary perfusion in selected organs was studied in two methods of CPR. Flows were measured during sinus rhythm and at two and ten minutes of CPR by injection of labeled microspheres. Cardiac output during CPR was redistributed, with a higher percentage directed cephalad. Brain blood flow during early CPR was preserved, but flow decreased significantly (P less than .05) by ten minutes. Flow to all other organs also decreased over time in CPR, but the differences were significant only for organs above the diaphragm and spleen. Although CPR with abdominal binding as compared to CPR without binding did not significantly increase flow to any organ (P less than .05), flow with binding (versus without binding) was higher to the organs above the diaphragm and lower to organs below the diaphragm." ], "offsets": [ [ 96, 966 ] ] } ]

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[ { "id": "20981579_title", "type": "title", "text": [ "Potential protective role of IL15Ralpha during inflammation." ], "offsets": [ [ 0, 60 ] ] }, { "id": "20981579_abstract", "type": "abstract", "text": [ "We have shown that TNFalpha specifically activates the interleukin-15 (IL15) system in cerebral endothelial cells composing the blood-brain barrier. To determine the functions of cerebral IL15 signaling in inflammation, we first treated mice with lipopolysaccharide (LPS) and determined the expression of the three receptor subtypes of IL15. Robust time-dependent upregulation occurred in all subunits. We then tested whether IL15Ralpha knockout (KO) affected the maintenance of body temperature and activity level after a single dose of LPS. Circadian telemetry data were analyzed by the cosinor method. Both wild-type and KO mice had clear 24-h rhythms of basal temperature and activity. KO mice had a significantly higher midline estimating statistic of rhythm (MESOR; approximating 24 h mean) of temperature and delayed 24-h acrophase (peak) of activity than the wild-type mice. LPS disrupted the circadian rhythm of activity more severely in the KO group. Besides a decrease in MESOR and 24-h amplitude of activity after LPS, the KO mice showed a significant reduction of MESOR, amplitude, and changed acrophase for temperature on the second of 2 days. The disrupted circadian rhythm of temperature and activity in the KO mice after LPS suggests that upregulated IL15 receptors may serve a beneficial role to counteract the consequences of neuroinflammation." ], "offsets": [ [ 61, 1424 ] ] } ]

[ { "id": "20981579_16169_0", "type": "Gene", "text": [ "IL15Ralpha" ], "offsets": [ [ 29, 39 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16169" } ] }, { "id": "20981579_MESH:D007249_1", "type": "Disease", "text": [ "inflammation" ], "offsets": [ [ 47, 59 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007249" } ] }, { "id": "20981579_21926_2", "type": "Gene", "text": [ "TNFalpha" ], "offsets": [ [ 80, 88 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "21926" } ] }, { "id": "20981579_16168_3", "type": "Gene", "text": [ "interleukin-15" ], "offsets": [ [ 116, 130 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16168" } ] }, { "id": "20981579_16168_4", "type": "Gene", "text": [ "IL15" ], "offsets": [ [ 132, 136 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16168" } ] }, { "id": "20981579_16168_5", "type": "Gene", "text": [ "IL15" ], "offsets": [ [ 249, 253 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16168" } ] }, { "id": "20981579_MESH:D007249_6", "type": "Disease", "text": [ "inflammation" ], "offsets": [ [ 267, 279 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007249" } ] }, { "id": "20981579_10090_7", "type": "Species", "text": [ "mice" ], "offsets": [ [ 298, 302 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "20981579_MESH:D008070_8", "type": "Chemical", "text": [ "lipopolysaccharide" ], "offsets": [ [ 308, 326 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008070" } ] }, { "id": "20981579_MESH:D008070_9", "type": "Chemical", "text": [ "LPS" ], "offsets": [ [ 328, 331 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008070" } ] }, { "id": "20981579_16168_10", "type": "Gene", "text": [ "IL15" ], "offsets": [ [ 397, 401 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16168" } ] }, { "id": "20981579_16169_11", "type": "Gene", "text": [ "IL15Ralpha" ], "offsets": [ [ 487, 497 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16169" } ] }, { "id": "20981579_MESH:D008070_12", "type": "Chemical", "text": [ "LPS" ], "offsets": [ [ 599, 602 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008070" } ] }, { "id": "20981579_10090_13", "type": "Species", "text": [ "mice" ], "offsets": [ [ 688, 692 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "20981579_10090_14", "type": "Species", "text": [ "mice" ], "offsets": [ [ 754, 758 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "20981579_10090_15", "type": "Species", "text": [ "mice" ], "offsets": [ [ 938, 942 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "20981579_MESH:D008070_16", "type": "Chemical", "text": [ "LPS" ], "offsets": [ [ 944, 947 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008070" } ] }, { "id": "20981579_MESH:D008070_17", "type": "Chemical", "text": [ "LPS" ], "offsets": [ [ 1087, 1090 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008070" } ] }, { "id": "20981579_10090_18", "type": "Species", "text": [ "mice" ], "offsets": [ [ 1099, 1103 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "20981579_10090_19", "type": "Species", "text": [ "mice" ], "offsets": [ [ 1288, 1292 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "20981579_MESH:D008070_20", "type": "Chemical", "text": [ "LPS" ], "offsets": [ [ 1299, 1302 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008070" } ] } ]

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[ { "id": "34352781_title", "type": "title", "text": [ "Approaches to Growth Faltering." ], "offsets": [ [ 0, 31 ] ] }, { "id": "34352781_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 32, 32 ] ] } ]

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[ { "id": "13482655_title", "type": "title", "text": [ "[1-4-Dimethanesulfoxybutane therapy of chronic leukemic myeloses]." ], "offsets": [ [ 0, 66 ] ] }, { "id": "13482655_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 67, 67 ] ] } ]

[ { "id": "13482655_-_0", "type": "Chemical", "text": [ "1-4-Dimethanesulfoxybutane" ], "offsets": [ [ 1, 27 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "13482655_MESH:D004915_1", "type": "Disease", "text": [ "chronic leukemic myeloses" ], "offsets": [ [ 39, 64 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004915" } ] } ]

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[ { "id": "7098180_title", "type": "title", "text": [ "[Studies on broncho-alveolar-lavage-fluid in sarcoidosis--the protein components (author's transl)]." ], "offsets": [ [ 0, 100 ] ] }, { "id": "7098180_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 101, 101 ] ] } ]

[ { "id": "7098180_MESH:D012507_0", "type": "Disease", "text": [ "sarcoidosis" ], "offsets": [ [ 45, 56 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012507" } ] } ]

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[ { "id": "22785543_title", "type": "title", "text": [ "Rhinosporidiosis in southwest Bengal." ], "offsets": [ [ 0, 37 ] ] }, { "id": "22785543_abstract", "type": "abstract", "text": [ "Rhinosporidiosis is a non-contagious chronic granulomatous disease that is prevalent in southern India and Sri Lanka. It has been known for centuries, but the details of the disease and the precise manner of its transmission have, until recently, remained unknown. Our institution sees many cases of this disease and we investigate the management protocol and its recent advances and include a review of the published literature. A total of 152 patients who were treated at Bankura Sammilani Medical College were studied between 2005 and 2011. The most common age group affected were those aged between 11 and 20 years of age and the male-to-female ratio was 1.9:1. Three patients suffered recurrent disease - one experienced it on the same site and the others on distant sites. Eleven patients with inadequate excision in which the margins were not free from disease were treated with dapsone therapy without any reported recurrence. It is a common disease in southwestern West Bengal. Surgical excision with electrocoagulation of the base is the main treatment, and dapsone therapy is recommended in order to prevent recurrences in multiple sites of affection and inadequate surgically excised cases. Although the disease occurs sporadically in most parts of the world, we see many patients in our area." ], "offsets": [ [ 38, 1343 ] ] } ]

[ { "id": "22785543_MESH:D012227_0", "type": "Disease", "text": [ "Rhinosporidiosis" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012227" } ] }, { "id": "22785543_MESH:D012227_1", "type": "Disease", "text": [ "Rhinosporidiosis" ], "offsets": [ [ 38, 54 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012227" } ] }, { "id": "22785543_MESH:D006105_2", "type": "Disease", "text": [ "chronic granulomatous disease" ], "offsets": [ [ 75, 104 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006105" } ] }, { "id": "22785543_6717_3", "type": "Gene", "text": [ "Sri" ], "offsets": [ [ 145, 148 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "6717" } ] }, { "id": "22785543_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 483, 491 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "22785543_9606_5", "type": "Species", "text": [ "patients" ], "offsets": [ [ 710, 718 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "22785543_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 824, 832 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "22785543_MESH:D003622_7", "type": "Chemical", "text": [ "dapsone" ], "offsets": [ [ 924, 931 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003622" } ] }, { "id": "22785543_MESH:D003622_8", "type": "Chemical", "text": [ "dapsone" ], "offsets": [ [ 1106, 1113 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003622" } ] }, { "id": "22785543_9606_9", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1322, 1330 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "31288164_title", "type": "title", "text": [ "Nutritional and organoleptic properties of murta (Ugni molinae Turcz) berries impregnated with Lactobacillus casei var. rhamnosus and dehydrated by different methods." ], "offsets": [ [ 0, 166 ] ] }, { "id": "31288164_abstract", "type": "abstract", "text": [ "This work evaluated nutritional and organoleptic properties of murta, a Chilean native berry, impregnated with Lactobacillus casei var. rhamnosus and dehydrated by different methods: freeze- (FD), convective- (CD) and vacuum- (VD) drying. Scanning electron microscopy revealed that L. casei localized at the peduncle and near the peduncle of the impregnated fruit. Murta enriched with probiotics contained higher L. casei viable counts after dehydration with FD compared to CD and VD methods. Overall, drying resulted in a decrease in crude fibre and phenolic compounds, which was attributed to L. casei metabolic activity suggesting that murta berries could act as prebiotics for L. casei. Among drying methods, L. casei enriched FD murta presented less alterations in the microstructure, less drying-induced damage and obtained a higher sensory acceptability score than CD and VD murta. Taken together, these results will contribute to the development of functional foods from regional products improving local economy." ], "offsets": [ [ 167, 1188 ] ] } ]

[ { "id": "31288164_260145_0", "type": "Species", "text": [ "Ugni molinae Turcz" ], "offsets": [ [ 50, 68 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "260145" } ] }, { "id": "31288164_47715_1", "type": "Species", "text": [ "Lactobacillus casei var. rhamnosus" ], "offsets": [ [ 95, 129 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "47715" } ] }, { "id": "31288164_47715_2", "type": "Species", "text": [ "Lactobacillus casei var. rhamnosus" ], "offsets": [ [ 278, 312 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "47715" } ] }, { "id": "31288164_MESH:D004402_3", "type": "Disease", "text": [ "FD" ], "offsets": [ [ 359, 361 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004402" } ] }, { "id": "31288164_MESH:D002104_4", "type": "Chemical", "text": [ "CD" ], "offsets": [ [ 377, 379 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002104" } ] }, { "id": "31288164_1582_5", "type": "Species", "text": [ "L. casei" ], "offsets": [ [ 449, 457 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1582" } ] }, { "id": "31288164_1582_6", "type": "Species", "text": [ "L. casei" ], "offsets": [ [ 580, 588 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1582" } ] }, { "id": "31288164_MESH:D003681_7", "type": "Disease", "text": [ "dehydration" ], "offsets": [ [ 609, 620 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003681" } ] }, { "id": "31288164_MESH:D004402_8", "type": "Disease", "text": [ "FD" ], "offsets": [ [ 626, 628 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004402" } ] }, { "id": "31288164_1582_9", "type": "Species", "text": [ "L. casei" ], "offsets": [ [ 762, 770 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1582" } ] }, { "id": "31288164_1582_10", "type": "Species", "text": [ "L. casei" ], "offsets": [ [ 848, 856 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1582" } ] }, { "id": "31288164_1582_11", "type": "Species", "text": [ "L. casei" ], "offsets": [ [ 880, 888 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1582" } ] }, { "id": "31288164_MESH:D004402_12", "type": "Disease", "text": [ "FD" ], "offsets": [ [ 898, 900 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004402" } ] }, { "id": "31288164_MESH:D002104_13", "type": "Chemical", "text": [ "CD" ], "offsets": [ [ 1039, 1041 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002104" } ] } ]

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[ { "id": "35850510_title", "type": "title", "text": [ "[Tumor Lysis Syndrome in a Patient with Germ Cell Tumor : A Case Report]." ], "offsets": [ [ 0, 73 ] ] }, { "id": "35850510_abstract", "type": "abstract", "text": [ "A 36-year-old man presented to our hospital with right scrotal swelling. A computed tomographic scan revealed a mass in the right scrotum, multiple masses in the lung and liver, and enlarged cervical, mediastinal, and retroperitoneal lymph nodes. After right high orchiectomy, he was diagnosed with nonseminomatous germ cell tumor (pT3N3M1b), with poor risk prediction according to the International Germ Cell Consensus classification. We started chemotherapy with bleomycin, etoposide, and cisplatin. Since serum alphafetoprotein (AFP) and human chorionic gonadotropin (HCG) levels did not decrease to normal levels, second-line chemotherapy with paclitaxel, ifosfamide, and cisplatin was administered. Six days after the start of treatment, the patient became unconscious, and his blood pressure decreased. Seven days later, blood tests revealed high uric acid levels, hyperphosphatemia, and increased creatinine. This was diagnosed as tumor lysis syndrome. Following diagnosis, continuous hemodiafiltration was started, and his condition gradually improved." ], "offsets": [ [ 74, 1134 ] ] } ]

[ { "id": "35850510_MESH:D015275_0", "type": "Disease", "text": [ "Tumor Lysis Syndrome" ], "offsets": [ [ 1, 21 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015275" } ] }, { "id": "35850510_9606_1", "type": "Species", "text": [ "Patient" ], "offsets": [ [ 27, 34 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35850510_MESH:D014063_2", "type": "Disease", "text": [ "right scrotal swelling" ], "offsets": [ [ 123, 145 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014063" } ] }, { "id": "35850510_MESH:C537844_3", "type": "Disease", "text": [ "nonseminomatous germ cell tumor" ], "offsets": [ [ 373, 404 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C537844" } ] }, { "id": "35850510_MESH:D001761_4", "type": "Chemical", "text": [ "bleomycin" ], "offsets": [ [ 539, 548 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001761" } ] }, { "id": "35850510_MESH:D005047_5", "type": "Chemical", "text": [ "etoposide" ], "offsets": [ [ 550, 559 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005047" } ] }, { "id": "35850510_MESH:D002945_6", "type": "Chemical", "text": [ "cisplatin" ], "offsets": [ [ 565, 574 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002945" } ] }, { "id": "35850510_174_7", "type": "Gene", "text": [ "alphafetoprotein" ], "offsets": [ [ 588, 604 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "174" } ] }, { "id": "35850510_93659_8", "type": "Gene", "text": [ "human chorionic gonadotropin" ], "offsets": [ [ 615, 643 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "93659" } ] }, { "id": "35850510_93659_9", "type": "Gene", "text": [ "HCG" ], "offsets": [ [ 645, 648 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "93659" } ] }, { "id": "35850510_MESH:D017239_10", "type": "Chemical", "text": [ "paclitaxel" ], "offsets": [ [ 722, 732 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D017239" } ] }, { "id": "35850510_MESH:D007069_11", "type": "Chemical", "text": [ "ifosfamide" ], "offsets": [ [ 734, 744 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007069" } ] }, { "id": "35850510_MESH:D002945_12", "type": "Chemical", "text": [ "cisplatin" ], "offsets": [ [ 750, 759 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002945" } ] }, { "id": "35850510_9606_13", "type": "Species", "text": [ "patient" ], "offsets": [ [ 821, 828 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35850510_MESH:D014527_14", "type": "Chemical", "text": [ "uric acid" ], "offsets": [ [ 927, 936 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014527" } ] }, { "id": "35850510_MESH:D054559_15", "type": "Disease", "text": [ "hyperphosphatemia" ], "offsets": [ [ 945, 962 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054559" } ] }, { "id": "35850510_MESH:D003404_16", "type": "Chemical", "text": [ "creatinine" ], "offsets": [ [ 978, 988 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003404" } ] }, { "id": "35850510_MESH:D015275_17", "type": "Disease", "text": [ "tumor lysis syndrome" ], "offsets": [ [ 1012, 1032 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015275" } ] } ]

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[ { "id": "24294386_title", "type": "title", "text": [ "Association between PKA gene polymorphism and NTDs in high risk Chinese population in Shanxi." ], "offsets": [ [ 0, 93 ] ] }, { "id": "24294386_abstract", "type": "abstract", "text": [ "OBJECTIVE: This study aimed to investigate the single nucleotide polymorphisms (SNPs) of PKA and neural tube defects (NTDs) in Chinese population. METHOD: A total of 183 NTDs cases and 200 healthy controls were used in this study. 7 selected single nucleotide polymorphism (SNP) sites in the PKA gene were analyzed with MassArray high-throughput DNA analyzer with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. A series of statistical methods were carried out to investigate the correlation between the SNPs and the patient susceptibility to NTDs. RESULTS: Statistical analysis showed a significant correlation between the SNP sites rs12132032 in PRKACB and NTDs. The AA genotype, A-allele and dominant AA in rs12132032 significantly increased the incidence of NTDs especially anencephaly (OR=3.87, 95% CI: 1.80-8.34 with genotype; OR=2.08, 95% CI: 1.43-3.04 with allele; OR=3.10, 95% CI: 1.53-6.26 with dominant). The T-allele of rs594631 in PRKACB was correlative with NTDs in male but not in female. CONCLUSIONS: The gene polymorphism loci rs12132032 in PRKACB maybe a potential risk factor for anencephaly in Chinese population from Shanxi, while gender susceptibility may influence the correlation." ], "offsets": [ [ 94, 1340 ] ] } ]

[ { "id": "24294386_MESH:D005184_0", "type": "Disease", "text": [ "NTDs" ], "offsets": [ [ 46, 50 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005184" } ] }, { "id": "24294386_MESH:D005184_1", "type": "Disease", "text": [ "neural tube defects" ], "offsets": [ [ 191, 210 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005184" } ] }, { "id": "24294386_MESH:D005184_2", "type": "Disease", "text": [ "NTDs" ], "offsets": [ [ 212, 216 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005184" } ] }, { "id": "24294386_MESH:D005184_3", "type": "Disease", "text": [ "NTDs" ], "offsets": [ [ 264, 268 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005184" } ] }, { "id": "24294386_9606_4", "type": "Species", "text": [ "patient" ], "offsets": [ [ 653, 660 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24294386_MESH:D005184_5", "type": "Disease", "text": [ "NTDs" ], "offsets": [ [ 679, 683 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005184" } ] }, { "id": "24294386_tmVar:rs12132032;VariantGroup:1;CorrespondingGene:5567;RS#:12132032_6", "type": "SNP", "text": [ "rs12132032" ], "offsets": [ [ 770, 780 ] ], "normalized": [ { "db_name": "unknown", "db_id": "tmVar:rs12132032;VariantGroup:1;CorrespondingGene:5567;RS#:12132032" } ] }, { "id": "24294386_5567_7", "type": "Gene", "text": [ "PRKACB" ], "offsets": [ [ 784, 790 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5567" } ] }, { "id": "24294386_MESH:D005184_8", "type": "Disease", "text": [ "NTDs" ], "offsets": [ [ 795, 799 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005184" } ] }, { "id": "24294386_tmVar:rs12132032;VariantGroup:1;CorrespondingGene:5567;RS#:12132032_9", "type": "SNP", "text": [ "rs12132032" ], "offsets": [ [ 846, 856 ] ], "normalized": [ { "db_name": "unknown", "db_id": "tmVar:rs12132032;VariantGroup:1;CorrespondingGene:5567;RS#:12132032" } ] }, { "id": "24294386_MESH:D005184_10", "type": "Disease", "text": [ "NTDs" ], "offsets": [ [ 898, 902 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005184" } ] }, { "id": "24294386_MESH:D000757_11", "type": "Disease", "text": [ "anencephaly" ], "offsets": [ [ 914, 925 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000757" } ] }, { "id": "24294386_tmVar:rs594631;VariantGroup:0;CorrespondingGene:5567;RS#:594631_12", "type": "SNP", "text": [ "rs594631" ], "offsets": [ [ 1068, 1076 ] ], "normalized": [ { "db_name": "unknown", "db_id": "tmVar:rs594631;VariantGroup:0;CorrespondingGene:5567;RS#:594631" } ] }, { "id": "24294386_5567_13", "type": "Gene", "text": [ "PRKACB" ], "offsets": [ [ 1080, 1086 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5567" } ] }, { "id": "24294386_MESH:D005184_14", "type": "Disease", "text": [ "NTDs" ], "offsets": [ [ 1108, 1112 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005184" } ] }, { "id": "24294386_tmVar:rs12132032;VariantGroup:1;CorrespondingGene:5567;RS#:12132032_15", "type": "SNP", "text": [ "rs12132032" ], "offsets": [ [ 1180, 1190 ] ], "normalized": [ { "db_name": "unknown", "db_id": "tmVar:rs12132032;VariantGroup:1;CorrespondingGene:5567;RS#:12132032" } ] }, { "id": "24294386_5567_16", "type": "Gene", "text": [ "PRKACB" ], "offsets": [ [ 1194, 1200 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5567" } ] }, { "id": "24294386_MESH:D000757_17", "type": "Disease", "text": [ "anencephaly" ], "offsets": [ [ 1235, 1246 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000757" } ] } ]

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[ { "id": "7813458_title", "type": "title", "text": [ "Influence of the four leader sequences of the human insulin-like-growth-factor-2 mRNAs on the expression of reporter genes." ], "offsets": [ [ 0, 123 ] ] }, { "id": "7813458_abstract", "type": "abstract", "text": [ "The human insulin-like-growth-factor-2 (IGF-2) gene generates mRNAs with four different leader sequences, but with identical coding and trailing regions. Previous research has revealed that the leader-2-containing and leader-4-containing mRNAs are completely polysomal, whereas mRNAs possessing leader-3 are predominantly present in the untranslated free messenger ribonucleoprotein particle (mRNP), both in cell lines and in foetal liver tissue. To investigate the influence of the IGF-2 leader sequences on expression of the gene, IGF-2 leader-luciferase and leader-chloramphenicol acetyltransferase fusion constructs were transfected transiently into different cell lines. In these experiments, the levels of expression obtained by constructs with leader-1, leader-2 and leader-4 were very similar, both at the level of mRNA and protein. Leader-3, however, strongly repressed the expression of the fusion mRNA via an unknown mechanism. This repression appeared to be confined to nucleotides at positions 328-906 of the leader sequence. The remaining 5' part of the leader sequence was efficient both in RNA expression and in translation, but the 3' part of the leader (nucleotides 906-1180) again moderately repressed luciferase expression, possibly due to endonucleolytic cleavage in this region of the RNA. To evaluate the effect of the IGF-2 leaders on in vitro translation, leader-chloramphenicol acetyltransferase fusion mRNAs were synthesized and translated in reticulocyte lysates. Compared to a chloramphenicol acetyltransferase control RNA, leader-1-chloramphenicol acetyltransferase mRNA translated over 20-fold less efficiently, whereas leader-2 repressed translation of its chloramphenicol acetyltransferase mRNA moderately (3-5 fold). Despite a general improvement of the translation efficiency upon translation in HeLa lysate, these discrepancies with the transfection data persisted. Translation of leader-3-containing mRNAs in reticulocyte lysates was barely detectable. The whole 5' region of leader-3, up to nucleotide 614, could be shown to be repressive. Only leader-4 directed translation of the chloramphenicol acetyltransferase open reading frame efficiently. As with leader-1 and leader-2, this L4-chloramphenicol acetyltransferase mRNA translated in a cap-dependent manner under the conditions of our experiments; translation of this mRNA was relatively resistant to addition of cap analogue. We conclude that all four IGF-2 leader sequences differ in their translational properties. This makes it likely that changes in the translational machinery will affect the expression of the various IGF-2 mRNAs differentially." ], "offsets": [ [ 124, 2770 ] ] } ]

[ { "id": "7813458_9606_0", "type": "Species", "text": [ "human" ], "offsets": [ [ 46, 51 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "7813458_3481_1", "type": "Gene", "text": [ "insulin-like-growth-factor-2" ], "offsets": [ [ 52, 80 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3481" } ] }, { "id": "7813458_9606_2", "type": "Species", "text": [ "human" ], "offsets": [ [ 128, 133 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "7813458_3481_3", "type": "Gene", "text": [ "insulin-like-growth-factor-2" ], "offsets": [ [ 134, 162 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3481" } ] }, { "id": "7813458_3481_4", "type": "Gene", "text": [ "IGF-2" ], "offsets": [ [ 164, 169 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3481" } ] }, { "id": "7813458_3481_5", "type": "Gene", "text": [ "IGF-2" ], "offsets": [ [ 607, 612 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3481" } ] }, { "id": "7813458_3481_6", "type": "Gene", "text": [ "IGF-2" ], "offsets": [ [ 657, 662 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3481" } ] }, { "id": "7813458_3481_7", "type": "Gene", "text": [ "IGF-2" ], "offsets": [ [ 1466, 1471 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3481" } ] }, { "id": "7813458_MESH:D002701_8", "type": "Chemical", "text": [ "chloramphenicol" ], "offsets": [ [ 1512, 1527 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002701" } ] }, { "id": "7813458_MESH:D002701_9", "type": "Chemical", "text": [ "chloramphenicol" ], "offsets": [ [ 1630, 1645 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002701" } ] }, { "id": "7813458_MESH:D002701_10", "type": "Chemical", "text": [ "chloramphenicol" ], "offsets": [ [ 1813, 1828 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002701" } ] }, { "id": "7813458_MESH:D002701_11", "type": "Chemical", "text": [ "chloramphenicol" ], "offsets": [ [ 2244, 2259 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002701" } ] }, { "id": "7813458_3481_12", "type": "Gene", "text": [ "IGF-2" ], "offsets": [ [ 2571, 2576 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3481" } ] }, { "id": "7813458_3481_13", "type": "Gene", "text": [ "IGF-2" ], "offsets": [ [ 2743, 2748 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3481" } ] } ]

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[ { "id": "5316_title", "type": "title", "text": [ "[Effect of electrolytes on the extraction of coniine, phenatin, cyclodol and tropacine by organic solvents]." ], "offsets": [ [ 0, 108 ] ] }, { "id": "5316_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 109, 109 ] ] } ]

[ { "id": "5316_MESH:C007112_0", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 45, 52 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C007112" } ] }, { "id": "5316_-_1", "type": "Chemical", "text": [ "phenatin" ], "offsets": [ [ 54, 62 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "5316_MESH:D014282_2", "type": "Chemical", "text": [ "cyclodol" ], "offsets": [ [ 64, 72 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014282" } ] }, { "id": "5316_MESH:C003727_3", "type": "Chemical", "text": [ "tropacine" ], "offsets": [ [ 77, 86 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C003727" } ] } ]

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[ { "id": "21702134_title", "type": "title", "text": [ "[I. Metabolic disease: 1. Diabetic nephropathy]." ], "offsets": [ [ 0, 48 ] ] }, { "id": "21702134_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 49, 49 ] ] } ]

[ { "id": "21702134_MESH:D008659_0", "type": "Disease", "text": [ "Metabolic disease" ], "offsets": [ [ 4, 21 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008659" } ] }, { "id": "21702134_MESH:D003928_1", "type": "Disease", "text": [ "Diabetic nephropathy" ], "offsets": [ [ 26, 46 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003928" } ] } ]

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[ { "id": "21603058_title", "type": "title", "text": [ "A one-year longitudinal study of English and Japanese vowel production by Japanese adults and children in an English-speaking setting." ], "offsets": [ [ 0, 134 ] ] }, { "id": "21603058_abstract", "type": "abstract", "text": [ "The effect of age of acquisition on first- and second-language vowel production was investigated. Eight English vowels were produced by Native Japanese (NJ) adults and children as well as by age-matched Native English (NE) adults and children. Productions were recorded shortly after the NJ participants' arrival in the USA and then one year later. In agreement with previous investigations [Aoyama, et al., J. Phon. 32, 233-250 (2004)], children were able to learn more, leading to higher accuracy than adults in a year's time. Based on the spectral quality and duration comparisons, NJ adults had more accurate production at Time 1, but showed no improvement over time. The NJ children's productions, however, showed significant differences from the NE children's for English \"new\" vowels /I/, /epsilon/, /alpha/, /v/ and /upsilon/ at Time 1, but produced all eight vowels in a native-like manner at Time 2. An examination of NJ speakers' productions of Japanese /i/, /a/, /u/ over time revealed significant changes for the NJ Child Group only. Japanese /i/ and /a/ showed changes in production that can be related to second language (L2) learning. The results suggest that L2 vowel production is affected importantly by age of acquisition and that there is a dynamic interaction, whereby the first and second language vowels affect each other." ], "offsets": [ [ 135, 1481 ] ] } ]

[ { "id": "21603058_9606_0", "type": "Species", "text": [ "children" ], "offsets": [ [ 94, 102 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "21603058_9606_1", "type": "Species", "text": [ "children" ], "offsets": [ [ 303, 311 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "21603058_9606_2", "type": "Species", "text": [ "children" ], "offsets": [ [ 369, 377 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "21603058_9606_3", "type": "Species", "text": [ "participants" ], "offsets": [ [ 426, 438 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "21603058_9606_4", "type": "Species", "text": [ "children" ], "offsets": [ [ 573, 581 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "21603058_9606_5", "type": "Species", "text": [ "children" ], "offsets": [ [ 814, 822 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "21603058_9606_6", "type": "Species", "text": [ "children" ], "offsets": [ [ 890, 898 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "21603058_9606_7", "type": "Species", "text": [ "Child" ], "offsets": [ [ 1164, 1169 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "20000119_title", "type": "title", "text": [ "[Comatose states: etiopathogenesis, experimental studies, treatment of hepatic coma]." ], "offsets": [ [ 0, 85 ] ] }, { "id": "20000119_abstract", "type": "abstract", "text": [ "The review presents the modern concepts on biochemical mechanisms of processes, that result in comatose states (CS), with emphasis on the search of new therapeutic approaches. CS of various origin causes severe suppression of brain cells functioning and stable unconsciousness. Numerous reasons of various CS are classified into two main groups: primary brain damages (ischemia, tumor, trauma) and secondary damages originating from system injuries in the body (endocrine, toxic e. c.). The most often primary CS is the hypoxic-ischemic one, as result of corresponding encephalopathy. Its mechanism is the brain cells \"energy crisis\"--because of decreased blood supply or its deficiency by energy substrates or/and by oxygen. Among secondary CS the substantial place takes hepatic coma as a consequence of hepatic encephalopathy in severe liver diseases--cirrhosis, acute liver failure, sharp intoxication. Its main reason is associated with exess of ammonia entering the brain tissue (it accumulates in blood because of lack of its removing by damaged hepatocytes). Ammonia reacts with glutamate in brain astrocytes and the product of this reaction, glutamine, induced osmotic imbalance, that results in change of form and functions of these important brain cells. It induces, in turn, neurons functions damages, changes in neurotransmission and cerebral blood flow and all these may give rise CS. The most of CS studies are carried out in human. Experimental models ofhepatic CS are reproduced mainly in rats, the most often by surgery methods. Other models included administration of thioacetamide or D-galactosamine, sometimes in combination with lipopolysaccharide. In earlier studies ammonia administration together with liver damages by ligation or by CCl4 was used. The main principles of hepatic coma treatment include the care of encephalopathy, detoxification, and liver treatment. Elaboration of new nanodrugs with increased penetration into tissues and cells, in particular, on the base of phospholipid nanoparticles, may increase substantially the therapeuti efficiency. One of such drug is thought to be a new hepatoprotective preparation phosphogliv--nanoparticles of soy phosphatidylcholine with glycyrrhizic acid. It is supposed, that the further development of phospholipid nanoforms, with minimal particle sizes, may reveal the more action in CS treatment." ], "offsets": [ [ 86, 2462 ] ] } ]

[ { "id": "20000119_MESH:D006501_0", "type": "Disease", "text": [ "hepatic coma" ], "offsets": [ [ 71, 83 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006501" } ] }, { "id": "20000119_1431_1", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 198, 200 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1431" } ] }, { "id": "20000119_1431_2", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 262, 264 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1431" } ] }, { "id": "20000119_1431_3", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 392, 394 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1431" } ] }, { "id": "20000119_MESH:D007511_4", "type": "Disease", "text": [ "ischemia" ], "offsets": [ [ 455, 463 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007511" } ] }, { "id": "20000119_MESH:D009369_5", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 465, 470 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "20000119_MESH:D014947_6", "type": "Disease", "text": [ "trauma" ], "offsets": [ [ 472, 478 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014947" } ] }, { "id": "20000119_1431_7", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 596, 598 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1431" } ] }, { "id": "20000119_MESH:D007511_8", "type": "Disease", "text": [ "hypoxic-ischemic" ], "offsets": [ [ 606, 622 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007511" } ] }, { "id": "20000119_MESH:D001927_9", "type": "Disease", "text": [ "encephalopathy" ], "offsets": [ [ 655, 669 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001927" } ] }, { "id": "20000119_MESH:D007022_10", "type": "Disease", "text": [ "decreased blood supply" ], "offsets": [ [ 732, 754 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007022" } ] }, { "id": "20000119_MESH:D010100_11", "type": "Chemical", "text": [ "oxygen" ], "offsets": [ [ 804, 810 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010100" } ] }, { "id": "20000119_1431_12", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 828, 830 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1431" } ] }, { "id": "20000119_MESH:D006501_13", "type": "Disease", "text": [ "hepatic coma" ], "offsets": [ [ 859, 871 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006501" } ] }, { "id": "20000119_MESH:D006501_14", "type": "Disease", "text": [ "hepatic encephalopathy" ], "offsets": [ [ 892, 914 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006501" } ] }, { "id": "20000119_MESH:D008103_15", "type": "Disease", "text": [ "liver diseases--cirrhosis" ], "offsets": [ [ 925, 950 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008103" } ] }, { "id": "20000119_MESH:D017114_16", "type": "Disease", "text": [ "acute liver failure" ], "offsets": [ [ 952, 971 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D017114" } ] }, { "id": "20000119_MESH:D000641_17", "type": "Chemical", "text": [ "ammonia" ], "offsets": [ [ 1037, 1044 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000641" } ] }, { "id": "20000119_MESH:D000641_18", "type": "Chemical", "text": [ "Ammonia" ], "offsets": [ [ 1153, 1160 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000641" } ] }, { "id": "20000119_MESH:D018698_19", "type": "Chemical", "text": [ "glutamate" ], "offsets": [ [ 1173, 1182 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018698" } ] }, { "id": "20000119_MESH:D005973_20", "type": "Chemical", "text": [ "glutamine" ], "offsets": [ [ 1237, 1246 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005973" } ] }, { "id": "20000119_1431_21", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 1481, 1483 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1431" } ] }, { "id": "20000119_1431_22", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 1497, 1499 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1431" } ] }, { "id": "20000119_9606_23", "type": "Species", "text": [ "human" ], "offsets": [ [ 1527, 1532 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "20000119_170587_24", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 1564, 1566 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "170587" } ] }, { "id": "20000119_10116_25", "type": "Species", "text": [ "rats" ], "offsets": [ [ 1592, 1596 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "20000119_MESH:D013853_26", "type": "Chemical", "text": [ "thioacetamide" ], "offsets": [ [ 1673, 1686 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013853" } ] }, { "id": "20000119_-_27", "type": "Chemical", "text": [ "D-galactosamine" ], "offsets": [ [ 1690, 1705 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "20000119_MESH:D008070_28", "type": "Chemical", "text": [ "lipopolysaccharide" ], "offsets": [ [ 1737, 1755 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008070" } ] }, { "id": "20000119_MESH:D000641_29", "type": "Chemical", "text": [ "ammonia" ], "offsets": [ [ 1776, 1783 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000641" } ] }, { "id": "20000119_MESH:D002251_30", "type": "Chemical", "text": [ "CCl4" ], "offsets": [ [ 1845, 1849 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002251" } ] }, { "id": "20000119_MESH:D006501_31", "type": "Disease", "text": [ "hepatic coma" ], "offsets": [ [ 1883, 1895 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006501" } ] }, { "id": "20000119_MESH:D001927_32", "type": "Disease", "text": [ "encephalopathy" ], "offsets": [ [ 1926, 1940 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001927" } ] }, { "id": "20000119_MESH:D010743_33", "type": "Chemical", "text": [ "phospholipid" ], "offsets": [ [ 2089, 2101 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010743" } ] }, { "id": "20000119_MESH:D010713_34", "type": "Chemical", "text": [ "phosphatidylcholine" ], "offsets": [ [ 2274, 2293 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010713" } ] }, { "id": "20000119_MESH:D019695_35", "type": "Chemical", "text": [ "glycyrrhizic acid" ], "offsets": [ [ 2299, 2316 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019695" } ] }, { "id": "20000119_MESH:D010743_36", "type": "Chemical", "text": [ "phospholipid" ], "offsets": [ [ 2366, 2378 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010743" } ] }, { "id": "20000119_170587_37", "type": "Gene", "text": [ "CS" ], "offsets": [ [ 2449, 2451 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "170587" } ] } ]

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[ { "id": "27139795_title", "type": "title", "text": [ "Core strengthening and synchronized swimming: TRX suspension training in young female athletes." ], "offsets": [ [ 0, 96 ] ] }, { "id": "27139795_abstract", "type": "abstract", "text": [ "BACKGROUND: Developing muscle strength and full body stability is essential for the efficient execution of technical moves in synchronized swimming. However, many swimmers find it difficult to control body stability while executing particular figures in water. We evaluated the effects of TRX suspension training (2 sessions weekly for 6 months on core strength and core stability in young female. METHODS: Twenty synchronized swimmers (Beginners A category, mean age 10+-1 years) are divided in experimental group (EG; N.=10 athletes) and control group (CG; N.=10 athletes). EG received suspension training twice weekly (each session lasting about 15 min) as dryland exercises for 6 months in addition to routine training. CG completed routine training with conventional dryland exercises. Before (T1) and after (T2) completion of the study oblique and transversus abdominis muscle force was measured using a Stabilizer Pressure Biofeedback unit, in prone and supine positions, and isotonic muscle endurance was evaluated with the McGill Test. RESULTS: Non-parametric statistical analysis showed a significant increase (P<0.0001) in the majority of the parameters in the experimental group. CONCLUSIONS: The study results provide evidence for the benefit of integrating TRX suspension training in dryland exercises for muscle strengthening in young athletes practicing synchronized swimming, and in general reiterates the importance of strengthening the core area to ensure stability and specific adaptations, improve the quality of the movement and prevent against injury." ], "offsets": [ [ 97, 1673 ] ] } ]

[ { "id": "27139795_MESH:D014867_0", "type": "Chemical", "text": [ "water" ], "offsets": [ [ 351, 356 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] } ]

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[ { "id": "31669816_title", "type": "title", "text": [ "The late blooming amphipods: Global change promoted post-Jurassic ecological radiation despite Palaeozoic origin." ], "offsets": [ [ 0, 113 ] ] }, { "id": "31669816_abstract", "type": "abstract", "text": [ "The ecological radiation of amphipods is striking among crustaceans. Despite high diversity, global distribution and key roles in all aquatic environments, little is known about their ecological transitions, evolutionary timescale and phylogenetic relationships. It has previously been proposed that the amphipod ecological diversification began in the Late Palaeozoic. By contrast, due to their affinity for cold/oxygenated water and absence of pre-Cenozoic fossils, we hypothesized that the ecological divergence of amphipods arose throughout the cool Late Mesozoic/Cenozoic. We tested our hypothesis by inferring a large-scale, time-calibrated, multilocus phylogeny, and reconstructed evolutionary patterns for major ecological traits. Although our results reveal a Late Palaeozoic amphipod origin, diversification and ecological divergence ensued only in the Late Mesozoic, overcoming a protracted stasis in marine littoral habitats. Multiple independent post-Jurassic radiations took place in deep-sea, freshwater, terrestrial, pelagic and symbiotic environments, usually postdating deep-sea faunal extinctions, and corresponding with significant climatic cooling, tectonic reconfiguration, continental flooding, and increased oceanic oxygenation. We conclude that the profound Late Mesozoic global changes triggered a tipping point in amphipod evolution by unlocking ecological opportunities that promoted radiation into many new niches. Our study also provides a solid, time-calibrated, evolutionary framework to accelerate research on this overlooked, yet globally important taxon." ], "offsets": [ [ 114, 1703 ] ] } ]

[ { "id": "31669816_MESH:D014867_0", "type": "Chemical", "text": [ "water" ], "offsets": [ [ 539, 544 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] } ]

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[ { "id": "17477046_title", "type": "title", "text": [ "[Torsion lability of the O=C-N-H fragment in single dipeptide molecules of L-amino acids]." ], "offsets": [ [ 0, 90 ] ] }, { "id": "17477046_abstract", "type": "abstract", "text": [ "On the basis of ab initio MP2 and semi-empirical PM3 quantum-chemical calculations the bistability of the nonplanar O=C-N-H fragment in the structure of simple amides and dipeptides is discussed. The influence of the nature of amino acids on the structural polymorphism of the peptide group in dipeptides is shown." ], "offsets": [ [ 91, 405 ] ] } ]

[ { "id": "17477046_MESH:D002244_0", "type": "Chemical", "text": [ "C" ], "offsets": [ [ 27, 28 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002244" } ] }, { "id": "17477046_MESH:D004151_1", "type": "Chemical", "text": [ "dipeptide" ], "offsets": [ [ 52, 61 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004151" } ] }, { "id": "17477046_MESH:D000596_2", "type": "Chemical", "text": [ "L-amino acids" ], "offsets": [ [ 75, 88 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000596" } ] }, { "id": "17477046_-_3", "type": "Chemical", "text": [ "C-N-H" ], "offsets": [ [ 209, 214 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "17477046_MESH:D000577_4", "type": "Chemical", "text": [ "amides" ], "offsets": [ [ 251, 257 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000577" } ] }, { "id": "17477046_MESH:D004151_5", "type": "Chemical", "text": [ "dipeptides" ], "offsets": [ [ 262, 272 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004151" } ] }, { "id": "17477046_MESH:D004151_6", "type": "Chemical", "text": [ "dipeptides" ], "offsets": [ [ 385, 395 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004151" } ] } ]

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[ { "id": "26741243_title", "type": "title", "text": [ "Molecular evolution of American field strains of bluetongue and epizootic haemorrhagic disease viruses." ], "offsets": [ [ 0, 103 ] ] }, { "id": "26741243_abstract", "type": "abstract", "text": [ "Recent Orbivirus occurrences in the Americas have been investigated using whole genome amplification and sequencing followed by phylogenetic analysis. The bluetongue virus (BTV) and epizootic haemorrhagic disease virus (EHDV) whole genomes were amplified without prior sequence knowledge and deep sequenced. This technology was applied to evaluate BTV-3 isolates spanning 4 decades from Florida, Arkansas, Mississippi, South Dakota, Central America, and the Caribbean basin. The results of the dataset analysis are consistent with the hypothesis that these viruses were introduced into the United States from Central America and the Caribbean basin. A similar analysis has been performed on a recent BTV-2 isolate from California. It indicates that the BTV-2 strain was likely introduced into Florida and then moved South to the Caribbean and West to California. A historical (1955-2012) molecular characterisation of EHDV strains was also completed, and subsequently used as reference sequence for comparison of genomes from recent 2012 cattle isolates associated with clinical disease. Finally, this analysis was performed on BTV-11 isolated from 2 canine cases and demonstrated that the genome sequences of the virus isolates from these cases were almost identical. These studies indicate the value of this technology in understanding virus epidemiology and ecology." ], "offsets": [ [ 104, 1473 ] ] } ]

[ { "id": "26741243_MESH:D001819_0", "type": "Disease", "text": [ "bluetongue and epizootic haemorrhagic disease" ], "offsets": [ [ 49, 94 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001819" } ] }, { "id": "26741243_40051_1", "type": "Species", "text": [ "bluetongue virus" ], "offsets": [ [ 259, 275 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "40051" } ] }, { "id": "26741243_40051_2", "type": "Species", "text": [ "BTV" ], "offsets": [ [ 277, 280 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "40051" } ] }, { "id": "26741243_40054_3", "type": "Species", "text": [ "epizootic haemorrhagic disease virus" ], "offsets": [ [ 286, 322 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "40054" } ] }, { "id": "26741243_40054_4", "type": "Species", "text": [ "EHDV" ], "offsets": [ [ 324, 328 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "40054" } ] }, { "id": "26741243_35328_5", "type": "Species", "text": [ "BTV-2" ], "offsets": [ [ 804, 809 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "35328" } ] }, { "id": "26741243_35328_6", "type": "Species", "text": [ "BTV-2" ], "offsets": [ [ 857, 862 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "35328" } ] }, { "id": "26741243_40054_7", "type": "Species", "text": [ "EHDV" ], "offsets": [ [ 1022, 1026 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "40054" } ] }, { "id": "26741243_9913_8", "type": "Species", "text": [ "cattle" ], "offsets": [ [ 1142, 1148 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9913" } ] }, { "id": "26741243_40051_9", "type": "Species", "text": [ "BTV" ], "offsets": [ [ 1232, 1235 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "40051" } ] }, { "id": "26741243_9615_10", "type": "Species", "text": [ "canine" ], "offsets": [ [ 1255, 1261 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] } ]

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[ { "id": "6914833_title", "type": "title", "text": [ "[Severity of hepatitis B]." ], "offsets": [ [ 0, 26 ] ] }, { "id": "6914833_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 27, 27 ] ] } ]

[ { "id": "6914833_MESH:D006509_0", "type": "Disease", "text": [ "hepatitis B" ], "offsets": [ [ 13, 24 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006509" } ] } ]

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[ { "id": "6876158_title", "type": "title", "text": [ "Close relationship between certain nuclear and mitochondrial introns. Implications for the mechanism of RNA splicing." ], "offsets": [ [ 0, 117 ] ] }, { "id": "6876158_abstract", "type": "abstract", "text": [ "We present the first indication of a direct relationship between a nuclear and a mitochondrial splicing system. The intron in the precursor of the large, nuclearly coded ribosomal RNA of two species of Tetrahymena possesses all the features of a class of fungal mitochondrial introns. Sequences conserved in mitochondrial introns of different fungal species are also found in the same order in these Tetrahymena nuclear introns, and the intron RNA can be folded to form a secondary structure similar to that proposed for mitochondrial introns by Davies et al. (1982). This \"core\" secondary structure brings the ends of the intron together. Furthermore, the first intron in the precursor of the large, nuclearly coded rRNA of Physarum polycephalum also has the characteristic conserved sequences and core RNA secondary structure. The limited sequence data available suggest that the intron in the large rRNA of chloroplasts in Chlamydomonas reinhardtii also resembles the mitochondrial introns. Tetrahymena large nuclear rRNA introns also have an internal sequence that can act as an adaptor by pairing with upstream and downstream exon sequences adjacent to the splice junctions to precisely align the splice junctions. These nuclear introns therefore fit the model of the role of intron RNA in the splicing process that was proposed by Davies et al. (1982), suggesting that the mechanisms of splicing may be very similar in these apparently diverse systems. It is therefore probable that the RNA secondary structures for which there is good evidence in the case of mitochondrial introns will be found to form the basis of active site structure and precise alignment in splicing and cyclization of the Tetrahymena intron \"ribozyme\"." ], "offsets": [ [ 118, 1850 ] ] } ]

[ { "id": "6876158_5791_0", "type": "Species", "text": [ "Physarum polycephalum" ], "offsets": [ [ 843, 864 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "5791" } ] }, { "id": "6876158_3055_1", "type": "Species", "text": [ "Chlamydomonas reinhardtii" ], "offsets": [ [ 1044, 1069 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "3055" } ] } ]

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[ { "id": "5964859_title", "type": "title", "text": [ "Experimental funnel chest (pectus excavatum)." ], "offsets": [ [ 0, 45 ] ] }, { "id": "5964859_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 46, 46 ] ] } ]

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[ { "id": "30848767_title", "type": "title", "text": [ "[Healthcare of transgenders by non-specialists in Chile]." ], "offsets": [ [ 0, 57 ] ] }, { "id": "30848767_abstract", "type": "abstract", "text": [ "The health care demand for transgenders has increased in Chile and worldwide. However, in Chile health care professionals are not trained to understand and face this problem. We herein review issues that should be considered in the training of non-specialist physicians to provide health care to transgenders, issues about terminology of body reassignment treatments and gender identity and the way Chilean professionals should deal with transgender persons." ], "offsets": [ [ 58, 516 ] ] } ]

[ { "id": "30848767_9606_0", "type": "Species", "text": [ "persons" ], "offsets": [ [ 508, 515 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "16519324_title", "type": "title", "text": [ "Dissolved copper triggers cell death in the peripheral mechanosensory system of larval fish." ], "offsets": [ [ 0, 92 ] ] }, { "id": "16519324_abstract", "type": "abstract", "text": [ "Dissolved copper is an increasingly common non-point source contaminant in urban and urbanizing watersheds. In the present study, we investigated the sublethal effects of dissolved copper on the peripheral mechanosensory system, or lateral line, of larval zebrafish (Danio rerio). Zebrafish larvae were exposed to copper (0-65 microg/L), and the cytotoxic responses of individual lateral line receptor neurons were examined using a combination of in vivo fluorescence imaging, confocal microscopy, scanning electron microscopy, and conventional histology. Dissolved copper triggered a dose-dependent loss of neurons in identified lateral line neuromasts at concentrations > or = 20 microg/L. The onset of cell death in the larval mechanosensory system was rapid (< 1 h). When copper-exposed zebrafish were transferred to clean water, the lateral line regenerated over the course of 2 d. In contrast, the lateral line of larvae exposed continuously to dissolved copper (50 microg/L) for 3 d did not recover. Collectively, these results show that peripheral mechanosensory neurons are vulnerable to the neurotoxic effects of copper. Consequently, dissolved copper in non-point source storm-water runoff has the potential to interfere with rheotaxis, schooling, predator avoidance, and other mechanosensory-mediated behaviors that are important for the migration and survival of fish." ], "offsets": [ [ 93, 1474 ] ] } ]

[ { "id": "16519324_MESH:D003300_0", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 10, 16 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_MESH:D003300_1", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 103, 109 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_MESH:D003300_2", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 274, 280 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_7955_3", "type": "Species", "text": [ "zebrafish" ], "offsets": [ [ 349, 358 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "7955" } ] }, { "id": "16519324_7955_4", "type": "Species", "text": [ "Danio rerio" ], "offsets": [ [ 360, 371 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "7955" } ] }, { "id": "16519324_7955_5", "type": "Species", "text": [ "Zebrafish" ], "offsets": [ [ 374, 383 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "7955" } ] }, { "id": "16519324_MESH:D003300_6", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 407, 413 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_MESH:D003300_7", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 659, 665 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_MESH:D003300_8", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 869, 875 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_7955_9", "type": "Species", "text": [ "zebrafish" ], "offsets": [ [ 884, 893 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "7955" } ] }, { "id": "16519324_MESH:D014867_10", "type": "Chemical", "text": [ "water" ], "offsets": [ [ 920, 925 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] }, { "id": "16519324_MESH:D003300_11", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 1054, 1060 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_MESH:D020258_12", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 1194, 1204 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] }, { "id": "16519324_MESH:D003300_13", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 1216, 1222 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_MESH:D003300_14", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 1248, 1254 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "16519324_MESH:D014867_15", "type": "Chemical", "text": [ "water" ], "offsets": [ [ 1281, 1286 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] } ]

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[ { "id": "10371050_title", "type": "title", "text": [ "Mercury contamination associated with artisanal gold mining on the island of Mindanao, the Philippines." ], "offsets": [ [ 0, 103 ] ] }, { "id": "10371050_abstract", "type": "abstract", "text": [ "The Agusan River basin of eastern Mindanao, the Philippines, hosts several centres of artisanal gold mining, the most important of which, Diwalwal, is a significant gold producer in global terms. An investigation of the environmental impacts of artisanal mining in the Agusan system, with particular reference to mercury contamination, was initiated in 1995 following reports of several incidents of human Hg poisoning in the province of Davao del Norte. Results show drainage downstream of Diwalwal is characterised by extremely high levels of Hg both in solution (maximum 2906 micrograms/l) and in bottom sediments (> 20 mg/kg). Filtered surface water Hg levels exceed the WHO Drinking Water guideline and the US-EPA Water Quality Criteria for the Protection of Aquatic Life for a downstream distance of more than 14 km, including channel sections utilised for fishing and potable water supply. The Environment Canada sediment quality Hg Toxic Effect Threshold for the Protection of Aquatic Life is exceeded for a downstream distance of 20 km. Hair Hg data indicate that ballmill and CIP plant operators processing Hg contaminated tailings at eastern Mindanao's principal gold beneficiation centre, Apokon, may be subject to enhanced occupational Hg exposure. It appears that the wider population of this area has not been affected." ], "offsets": [ [ 104, 1438 ] ] } ]

[ { "id": "10371050_MESH:D008628_0", "type": "Chemical", "text": [ "Mercury" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008628" } ] }, { "id": "10371050_MESH:D008628_1", "type": "Chemical", "text": [ "mercury" ], "offsets": [ [ 417, 424 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008628" } ] }, { "id": "10371050_9606_2", "type": "Species", "text": [ "human" ], "offsets": [ [ 504, 509 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "10371050_MESH:D011041_3", "type": "Disease", "text": [ "poisoning" ], "offsets": [ [ 513, 522 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011041" } ] }, { "id": "10371050_MESH:D014867_4", "type": "Chemical", "text": [ "water" ], "offsets": [ [ 752, 757 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] }, { "id": "10371050_MESH:D014867_5", "type": "Chemical", "text": [ "Water" ], "offsets": [ [ 792, 797 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] }, { "id": "10371050_MESH:D014867_6", "type": "Chemical", "text": [ "Water" ], "offsets": [ [ 823, 828 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] }, { "id": "10371050_MESH:D014867_7", "type": "Chemical", "text": [ "water" ], "offsets": [ [ 987, 992 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] }, { "id": "10371050_MESH:D010259_8", "type": "Disease", "text": [ "CIP" ], "offsets": [ [ 1190, 1193 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010259" } ] } ]

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[ { "id": "28084871_title", "type": "title", "text": [ "Airtraq laryngoscope: a solution for difficult laryngeal exposure in phonomicrosurgery." ], "offsets": [ [ 0, 87 ] ] }, { "id": "28084871_abstract", "type": "abstract", "text": [ "CONCLUSION: Airtraq laryngoscope can obviously improve laryngeal visualization and may provide a useful solution to treatment of patients with difficult laryngeal exposure (DLE) under a conventional suspension laryngoscope in phonomicrosurgery. OBJECTIVE: In phonomicrosurgery, otolaryngologists may inevitably encounter DLE. Attempts to improve laryngeal exposure have yielded important advances, but the prevalence of DLE yet remains persistent. To overcome this problem, this study applied the Airtraq laryngoscope to perform phonomicrosurgery combined with a video system. The aim of this study is, thus, to explore the clinical usefulness of the Airtraq laryngoscope in patients with DLE. METHODS: One hundred and fifty-eight cases who underwent phonomicrosurgery for benign lesions of vocal cord at this hospital were enrolled in this study, of which nine patients were confirmed to be DLE under direct suspension laryngoscope. These nine patients were treated by Airtraq laryngoscope together with a video system. RESULTS: In comparison with the traditional suspension laryngoscope, exposure of larynx was remarkably improved by Airtraq laryngoscope. Under the excellent laryngeal visualization provided by Airtraq , phonomicrosurgery was successfully accomplished for vocal fold lesions without any severe complications in all cases with DLE." ], "offsets": [ [ 88, 1443 ] ] } ]

[ { "id": "28084871_9606_0", "type": "Species", "text": [ "patients" ], "offsets": [ [ 218, 226 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "28084871_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 766, 774 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "28084871_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 953, 961 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "28084871_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1036, 1044 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "6173760_title", "type": "title", "text": [ "Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides." ], "offsets": [ [ 0, 91 ] ] }, { "id": "6173760_abstract", "type": "abstract", "text": [ "Molecular cloning and DNA sequencing have yielded considerable structural information about proenkephalin. All previously characterized intermediate peptides of the enkephalin pathways in bovine adrenal medulla have now been aligned into an unambiguous primary structure. Two basic amino acid residues serve as processing signals for release of each of the different components." ], "offsets": [ [ 92, 470 ] ] } ]

[ { "id": "6173760_MESH:D010455_0", "type": "Chemical", "text": [ "peptides" ], "offsets": [ [ 82, 90 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010455" } ] }, { "id": "6173760_9913_1", "type": "Species", "text": [ "bovine" ], "offsets": [ [ 280, 286 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9913" } ] }, { "id": "6173760_MESH:D024361_2", "type": "Chemical", "text": [ "basic amino acid" ], "offsets": [ [ 368, 384 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D024361" } ] } ]

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[ { "id": "13186275_title", "type": "title", "text": [ "[Rational concept of clinical ophthalmology education]." ], "offsets": [ [ 0, 55 ] ] }, { "id": "13186275_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 56, 56 ] ] } ]

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[ { "id": "31633918_title", "type": "title", "text": [ "Are Fully Conjugated Expanded Indenofluorenes Analogues and Diindeno[n]thiophene Derivatives Diradicals? A Simplified (Spin-Flip) Time-Dependent Density Functional Theory [(SF-)sTD-DFT] Study." ], "offsets": [ [ 0, 192 ] ] }, { "id": "31633918_abstract", "type": "abstract", "text": [ "Polycyclic hydrocarbons are often used to understand the electronic structure of nanographene systems. Among them, indeno[1,2b]fluorene and indeno[1,2c]fluorene isomers present a central p-quinodimethane unit leading to unique optical properties. In this work, we characterized the absorption spectra of indeno[1,2b]fluorene and [2,1-c]diindeno[n]thiophene derivatives with (spin-flip) simplified time-dependent density functional theory [(SF-)sTD-DFT] methods. Note that the SF-sTD-DFT level of theory allows a computationally efficient treatment for large diradicals. To interpret spectra, we implemented natural transition orbitals (NTOs) at both SF-sTD-DFT and sTD-DFT levels. This compact and method-independent representation of the electronic excitation provides a simple interpretation for the low-lying excited states of this set of molecules in terms of three different types of NTOs: \"quinoid\", \"aromatic\", and \"pi-bonded\". When comparing with experiment, we found that only one molecule of this set is actually a high-spin triplet diradical. Others are almost closed-shell molecules with a very small contribution from a doubly excited configuration that only the spin-flip method could capture. The small amount of static correlation recovered by the spin-flip active space provides a linear relation between the first visible theoretical and experimental excitation energies among this set." ], "offsets": [ [ 193, 1597 ] ] } ]

[ { "id": "31633918_-_0", "type": "Chemical", "text": [ "Expanded Indenofluorenes" ], "offsets": [ [ 21, 45 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31633918_-_1", "type": "Chemical", "text": [ "Diindeno[n]thiophene" ], "offsets": [ [ 60, 80 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31633918_MESH:D006844_2", "type": "Chemical", "text": [ "Polycyclic hydrocarbons" ], "offsets": [ [ 193, 216 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006844" } ] }, { "id": "31633918_-_3", "type": "Chemical", "text": [ "nanographene" ], "offsets": [ [ 274, 286 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31633918_-_4", "type": "Chemical", "text": [ "indeno[1,2b]fluorene" ], "offsets": [ [ 308, 328 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31633918_-_5", "type": "Chemical", "text": [ "indeno[1,2c]fluorene" ], "offsets": [ [ 333, 353 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31633918_-_6", "type": "Chemical", "text": [ "p-quinodimethane" ], "offsets": [ [ 380, 396 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31633918_-_7", "type": "Chemical", "text": [ "indeno[1,2b]fluorene" ], "offsets": [ [ 497, 517 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31633918_-_8", "type": "Chemical", "text": [ "[2,1-c]diindeno[n]thiophene" ], "offsets": [ [ 522, 549 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31633918_MESH:D012749_9", "type": "Disease", "text": [ "SF-sTD-DFT" ], "offsets": [ [ 669, 679 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012749" } ] }, { "id": "31633918_MESH:D012749_10", "type": "Disease", "text": [ "SF-sTD-DFT" ], "offsets": [ [ 843, 853 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012749" } ] }, { "id": "31633918_-_11", "type": "Chemical", "text": [ "quinoid" ], "offsets": [ [ 1089, 1096 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "22935829_title", "type": "title", "text": [ "[Integrated care of chronic obstructive pulmonary disease exacerbations: primary care and specialised care working together]." ], "offsets": [ [ 0, 125 ] ] }, { "id": "22935829_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 126, 126 ] ] } ]

[ { "id": "22935829_MESH:D029424_0", "type": "Disease", "text": [ "chronic obstructive pulmonary disease" ], "offsets": [ [ 20, 57 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D029424" } ] } ]

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[ { "id": "7520889_title", "type": "title", "text": [ "Novel psi-S-CH2 peptide-bond replacement and its utilization in the synthesis of nonpeptidic surrogates of the Leu-Asp-Val sequence that exhibit specific inhibitory activities on CD4+ T cell binding to fibronectin." ], "offsets": [ [ 0, 214 ] ] }, { "id": "7520889_abstract", "type": "abstract", "text": [ "The Leu-Asp-Val-(LDV)-containing amino acid sequence, derived from the alternatively spliced first connecting segment region of fibronectin (FN), was shown to be recognized primarily by the alpha 4 beta 1-integrin receptor expressed on the surface of various cell types. This adhesion epitope may therefore inhibit integrin-mediated cell interactions with the extracellular matrix glycoprotein, including adhesion, migration, activation and differentiation. To probe the structural requirements for LDV recognition by integrins and examine the feasibility of inhibition of LDV-dependent cell-FN interactions, we have designed and constructed a novel psi-S-CH2 peptide bond surrogate that was employed in the formation of LDV surrogates. The synthesis of the psi-S-CH2 surrogates reported herein is based on Michael addition of 4-methylpentane thiol to an itaconic acid diester to form an S-CH2 bond. We have found that the LDV surrogates comprises of 4-methylpentanoate-Asp-i-butyl amide and 8-methyl-3-(2-methylpropylaminocarbonyl)-5-thianonanoic acid interfered with CD4+ human T-cell adhesion to FN in vitro, with an ED50 of 280 micrograms/mL. A control structural mimetic of the Leu-Glu-Val (LEV) peptide did not interfere with the T-cell-FN interaction. The specificity of the reaction was substantiated by the finding that the LDV mimetics did not interfere with T-cell adhesion to laminin, another major cell-adhesive glycoprotein of the extracellular matrix.(ABSTRACT TRUNCATED AT 250 WORDS)" ], "offsets": [ [ 215, 1714 ] ] } ]

[ { "id": "7520889_MESH:C090763_0", "type": "Chemical", "text": [ "Leu-Asp-Val" ], "offsets": [ [ 111, 122 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C090763" } ] }, { "id": "7520889_920_1", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 179, 182 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "7520889_T cell_2", "type": "CellLine", "text": [ "T cell" ], "offsets": [ [ 184, 190 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "T cell" } ] }, { "id": "7520889_2335_3", "type": "Gene", "text": [ "fibronectin" ], "offsets": [ [ 202, 213 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "2335" } ] }, { "id": "7520889_MESH:C090763_4", "type": "Chemical", "text": [ "Leu-Asp-Val" ], "offsets": [ [ 219, 230 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C090763" } ] }, { "id": "7520889_2335_5", "type": "Gene", "text": [ "fibronectin" ], "offsets": [ [ 343, 354 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "2335" } ] }, { "id": "7520889_-_6", "type": "Chemical", "text": [ "psi-S-CH2" ], "offsets": [ [ 973, 982 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7520889_-_7", "type": "Chemical", "text": [ "4-methylpentane thiol" ], "offsets": [ [ 1042, 1063 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7520889_MESH:C005229_8", "type": "Chemical", "text": [ "itaconic acid" ], "offsets": [ [ 1070, 1083 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C005229" } ] }, { "id": "7520889_-_9", "type": "Chemical", "text": [ "CH2" ], "offsets": [ [ 1105, 1108 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7520889_-_10", "type": "Chemical", "text": [ "4-methylpentanoate-Asp-i-butyl amide" ], "offsets": [ [ 1166, 1202 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7520889_-_11", "type": "Chemical", "text": [ "8-methyl-3-(2-methylpropylaminocarbonyl)-5-thianonanoic acid" ], "offsets": [ [ 1207, 1267 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7520889_920_12", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 1284, 1287 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "7520889_9606_13", "type": "Species", "text": [ "human" ], "offsets": [ [ 1289, 1294 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "7520889_T cell_14", "type": "CellLine", "text": [ "T-cell" ], "offsets": [ [ 1295, 1301 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "T cell" } ] }, { "id": "7520889_-_15", "type": "Chemical", "text": [ "Leu-Glu-Val" ], "offsets": [ [ 1398, 1409 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7520889_-_16", "type": "Chemical", "text": [ "LEV" ], "offsets": [ [ 1411, 1414 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7520889_T cell_17", "type": "CellLine", "text": [ "T-cell" ], "offsets": [ [ 1451, 1457 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "T cell" } ] }, { "id": "7520889_T cell_18", "type": "CellLine", "text": [ "T-cell" ], "offsets": [ [ 1584, 1590 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "T cell" } ] } ]

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[ { "id": "4629965_title", "type": "title", "text": [ "[Use of dry hydrolysin for parenteral feeding of surgical patients]." ], "offsets": [ [ 0, 68 ] ] }, { "id": "4629965_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 69, 69 ] ] } ]

[ { "id": "4629965_9606_0", "type": "Species", "text": [ "patients" ], "offsets": [ [ 58, 66 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "3456726_title", "type": "title", "text": [ "A connection between bulimia and depression?" ], "offsets": [ [ 0, 44 ] ] }, { "id": "3456726_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 45, 45 ] ] } ]

[ { "id": "3456726_MESH:D000275_0", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 33, 43 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] } ]

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[ { "id": "20713186_title", "type": "title", "text": [ "Modern diagnosis of autoimmune blistering skin diseases." ], "offsets": [ [ 0, 56 ] ] }, { "id": "20713186_abstract", "type": "abstract", "text": [ "The diagnostic gold standard of autoimmune bullous diseases is the detection of autoantibodies in skin or mucous membranes by direct immunofluorescence microscopy of a perilesional biopsy. The molecular characterisation of several target antigens within the last 10 years has, however, fostered the development of sensitive and specific diagnostic tools that allow the serological diagnosis in about 90% of patients. Based on the recombinant immunodominant portions of the target antigens, ELISA systems are commercially available for the detection of circulating antibodies against desmoglein 1, desmoglein 3, envoplakin, BP180, and BP230. Autoantibodies against the soluble ectodomain of BP180 (LAD-1), laminin 332, type VII collagen, and most recently, laminin gamma1 can be detected by Western blotting with recombinant or cell-derived forms of these proteins. The definite differentiation between the various immunobullous disorders that comprise about a dozen entities is increasingly important since more diverse treatment options are employed. Exact diagnosis is also pivotal for the prognosis, since some autoimmune bullous diseases may indicate an underlying tumor. Association with a malignancy has been shown in paraneoplastic pemphigus (in 100%) and anti-laminin 332 mucous pemphigoid (in 25%) In pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid, autoantibodies to desmoglein 3, desmoglein 1, and BP180, respectively, have been shown to correlate with the disease activity. The detection of serum autoantibodies during the course of the disease may thus be helpful in guiding treatment decisions in these patients." ], "offsets": [ [ 57, 1699 ] ] } ]

[ { "id": "20713186_MESH:D012871_0", "type": "Disease", "text": [ "skin diseases" ], "offsets": [ [ 42, 55 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012871" } ] }, { "id": "20713186_MESH:D001327_1", "type": "Disease", "text": [ "autoimmune bullous diseases" ], "offsets": [ [ 89, 116 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001327" } ] }, { "id": "20713186_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 464, 472 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "20713186_1828_3", "type": "Gene", "text": [ "desmoglein 1" ], "offsets": [ [ 640, 652 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1828" } ] }, { "id": "20713186_1830_4", "type": "Gene", "text": [ "desmoglein 3" ], "offsets": [ [ 654, 666 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1830" } ] }, { "id": "20713186_2125_5", "type": "Gene", "text": [ "envoplakin" ], "offsets": [ [ 668, 678 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "2125" } ] }, { "id": "20713186_3898_6", "type": "Gene", "text": [ "LAD-1" ], "offsets": [ [ 754, 759 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3898" } ] }, { "id": "20713186_MESH:D030342_7", "type": "Disease", "text": [ "immunobullous disorders" ], "offsets": [ [ 971, 994 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D030342" } ] }, { "id": "20713186_MESH:D001327_8", "type": "Disease", "text": [ "autoimmune bullous diseases" ], "offsets": [ [ 1171, 1198 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001327" } ] }, { "id": "20713186_MESH:D009369_9", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 1226, 1231 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "20713186_MESH:D009369_10", "type": "Disease", "text": [ "malignancy" ], "offsets": [ [ 1252, 1262 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "20713186_MESH:D010392_11", "type": "Disease", "text": [ "paraneoplastic pemphigus" ], "offsets": [ [ 1281, 1305 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010392" } ] }, { "id": "20713186_1830_12", "type": "Gene", "text": [ "desmoglein 3" ], "offsets": [ [ 1450, 1462 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1830" } ] }, { "id": "20713186_1828_13", "type": "Gene", "text": [ "desmoglein 1" ], "offsets": [ [ 1464, 1476 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1828" } ] }, { "id": "20713186_9606_14", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1690, 1698 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "10912880_title", "type": "title", "text": [ "Diclofenac sodium (Voltaren) reduced exercise-induced injury in human skeletal muscle." ], "offsets": [ [ 0, 86 ] ] }, { "id": "10912880_abstract", "type": "abstract", "text": [ "PURPOSE: To examine the effects of prolonged systemic administration of diclofenac sodium (Voltaren), a nonsteroidal anti-inflammatory drug, on objective indices of exercise-induced muscle damage in humans. METHODS: Fifty-four volunteers (mean age, 26.4 yr; range, 18-35) participated in this randomized double-blind, placebo-controlled trial. To achieve steady-state tissue levels, either placebo or diclofenac was orally administered two times a day for 27 consecutive days. A strenuous 20-min stepping exercise program, about which the subjects were unfamiliar, was conducted on day 15. Creatine kinase (CK) activities were measured immediately before the exercise session and on days 16, 18, and 27. Vastus lateralis muscle samples were obtained immediately before exercise and on day 27 for subsequent histological characterization of muscle inflammation. RESULTS: The preexercise muscle samples revealed no difference in muscle damage between the two groups. However, the postexercise muscle samples showed that the diclofenac-treated group demonstrated less muscle tissue damage than placebo-treated subjects (P = 0.002). The administration of diclofenac also resulted in a significant lowering of post-/pre-exercise CK ratios on days 18 (P = 0.03) and 27 (P = 0.02) compared with the placebo group, an indirect finding that supports the possibility of diclofenac reducing exercise-induced muscle damage. CONCLUSION: These findings demonstrate preadministration of diclofenac (in accordance with tissue half-life pharmacokinetics) significantly reduces quantitative indices of exercise-induced skeletal muscle damage in human muscle." ], "offsets": [ [ 87, 1727 ] ] } ]

[ { "id": "10912880_MESH:D004008_0", "type": "Chemical", "text": [ "Diclofenac sodium" ], "offsets": [ [ 0, 17 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_MESH:D004008_1", "type": "Chemical", "text": [ "Voltaren" ], "offsets": [ [ 19, 27 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_9606_2", "type": "Species", "text": [ "human" ], "offsets": [ [ 64, 69 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "10912880_MESH:D004008_3", "type": "Chemical", "text": [ "diclofenac sodium" ], "offsets": [ [ 159, 176 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_MESH:D004008_4", "type": "Chemical", "text": [ "Voltaren" ], "offsets": [ [ 178, 186 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_MESH:D009135_5", "type": "Disease", "text": [ "muscle damage" ], "offsets": [ [ 269, 282 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009135" } ] }, { "id": "10912880_9606_6", "type": "Species", "text": [ "humans" ], "offsets": [ [ 286, 292 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "10912880_MESH:D004008_7", "type": "Chemical", "text": [ "diclofenac" ], "offsets": [ [ 488, 498 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_51727_8", "type": "Gene", "text": [ "Creatine kinase" ], "offsets": [ [ 677, 692 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "51727" } ] }, { "id": "10912880_51727_9", "type": "Gene", "text": [ "CK" ], "offsets": [ [ 694, 696 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "51727" } ] }, { "id": "10912880_MESH:D007249_10", "type": "Disease", "text": [ "muscle inflammation" ], "offsets": [ [ 927, 946 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007249" } ] }, { "id": "10912880_MESH:D009135_11", "type": "Disease", "text": [ "muscle damage" ], "offsets": [ [ 1014, 1027 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009135" } ] }, { "id": "10912880_MESH:D004008_12", "type": "Chemical", "text": [ "diclofenac" ], "offsets": [ [ 1109, 1119 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_MESH:D004008_13", "type": "Chemical", "text": [ "diclofenac" ], "offsets": [ [ 1238, 1248 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_51727_14", "type": "Gene", "text": [ "CK" ], "offsets": [ [ 1311, 1313 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "51727" } ] }, { "id": "10912880_MESH:D004008_15", "type": "Chemical", "text": [ "diclofenac" ], "offsets": [ [ 1447, 1457 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_MESH:D009135_16", "type": "Disease", "text": [ "muscle damage" ], "offsets": [ [ 1484, 1497 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009135" } ] }, { "id": "10912880_MESH:D004008_17", "type": "Chemical", "text": [ "diclofenac" ], "offsets": [ [ 1559, 1569 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004008" } ] }, { "id": "10912880_MESH:D005207_18", "type": "Disease", "text": [ "skeletal muscle damage" ], "offsets": [ [ 1688, 1710 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005207" } ] }, { "id": "10912880_9606_19", "type": "Species", "text": [ "human" ], "offsets": [ [ 1714, 1719 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "7721708_title", "type": "title", "text": [ "Similarity of \"core\" structures in two different glycans of tyrosine-linked eubacterial S-layer glycoproteins." ], "offsets": [ [ 0, 110 ] ] }, { "id": "7721708_abstract", "type": "abstract", "text": [ "Previously, the repeating-unit structure of the S-layer glycoprotein from the eubacterium Bacillus alvei CCM 2051 has been determined to be [-->3)-beta-D-Galp-(1-->4)-[alpha-D-Glcp-(1-->6)-]-beta-D-ManpNAc- (1-->]n (E. Altman, J.-R. Brisson, P. Messner, and U. B. Sleytr, Biochem. Cell Biol. 69:72-78, 1991). Nuclear magnetic resonance spectroscopic reexamination of this glycan reveals that the O-antigen-like domain of the polysaccharide is [see text] connected with the S-layer polypeptide through the \"core\" structure -->3)-alpha-L-Rhap-(1-->3)-alpha-L-Rhap-(1-->3)-alpha-L-R hap-(1-->3)-beta-D-Galp-(1-->O)-Tyr. Except for the substitution in position 4 of the nonreducing rhamnose with the modified glyceric acid phosphate residue GroA-2-->OPO2-->4-beta-D-ManpNAc-(1-->, this core is identical to the core of the tyrosine-linked glycan from the S-layer glycoprotein of Thermoanaerobacter thermohydrosulfuricus L111-69 (K. Bock, J. Schuster-Kolbe, E. Altman, G. Allmaier, B. Stahl, R. Christian, U. B. Sleytr, and P. Messner, J. Biol. Chem. 269:7137-7144, 1994)." ], "offsets": [ [ 111, 1178 ] ] } ]

[ { "id": "7721708_MESH:D011134_0", "type": "Chemical", "text": [ "glycans" ], "offsets": [ [ 49, 56 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011134" } ] }, { "id": "7721708_MESH:D014443_1", "type": "Chemical", "text": [ "tyrosine" ], "offsets": [ [ 60, 68 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014443" } ] }, { "id": "7721708_44250_2", "type": "Species", "text": [ "Bacillus alvei" ], "offsets": [ [ 201, 215 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "44250" } ] }, { "id": "7721708_-_3", "type": "Chemical", "text": [ ")-beta-D-Galp-(1-->4)-[alpha-D-Glcp-(1-->6)-]-beta-D-ManpNAc- (1-->]n" ], "offsets": [ [ 256, 325 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7721708_MESH:D011134_4", "type": "Chemical", "text": [ "glycan" ], "offsets": [ [ 483, 489 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011134" } ] }, { "id": "7721708_MESH:D011134_5", "type": "Chemical", "text": [ "polysaccharide" ], "offsets": [ [ 536, 550 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011134" } ] }, { "id": "7721708_-_6", "type": "Chemical", "text": [ ")-alpha-L-Rhap-(" ], "offsets": [ [ 637, 653 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7721708_-_7", "type": "Chemical", "text": [ ")-alpha-L-Rhap-(1-->" ], "offsets": [ [ 658, 678 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7721708_-_8", "type": "Chemical", "text": [ ")-alpha-L-R hap-(" ], "offsets": [ [ 679, 696 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7721708_-_9", "type": "Chemical", "text": [ ")-beta-D-Galp-(1-->O)-Tyr" ], "offsets": [ [ 701, 726 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "7721708_1516_10", "type": "Species", "text": [ "Thermoanaerobacter thermohydrosulfuricus" ], "offsets": [ [ 986, 1026 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1516" } ] } ]

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[ { "id": "30591348_title", "type": "title", "text": [ "Billiards-related dystonia: A new task-specific dystonia." ], "offsets": [ [ 0, 57 ] ] }, { "id": "30591348_abstract", "type": "abstract", "text": [ "We report the first videotaped case of focal and task-specific dystonia of the upper limb that occurred exclusively while using a cue during billiard playing. The repetitive movements in conjunction with a highly skilled performance likely contributed to the development of this focal dystonia." ], "offsets": [ [ 58, 352 ] ] } ]

[ { "id": "30591348_MESH:D004421_0", "type": "Disease", "text": [ "dystonia" ], "offsets": [ [ 18, 26 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004421" } ] }, { "id": "30591348_MESH:D004421_1", "type": "Disease", "text": [ "dystonia" ], "offsets": [ [ 48, 56 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004421" } ] }, { "id": "30591348_MESH:D038062_2", "type": "Disease", "text": [ "dystonia of the upper limb" ], "offsets": [ [ 121, 147 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D038062" } ] }, { "id": "30591348_MESH:D004421_3", "type": "Disease", "text": [ "dystonia" ], "offsets": [ [ 343, 351 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004421" } ] } ]

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[ { "id": "12166559_title", "type": "title", "text": [ "Bronchial reactions to the inhalation of high-dose tobramycin in cystic fibrosis." ], "offsets": [ [ 0, 81 ] ] }, { "id": "12166559_abstract", "type": "abstract", "text": [ "It has been established that inhaled tobramycin has a positive effect on respiratory function in Pseudomonas-aeruginosa positive patients with cystic fibrosis (CF). In a previous study the authors reported that low-dose tobramycin preparations containing the preservative phenol caused significant bronchial obstruction. Recently, high-dose tobramycin preparations with and without preservatives/phenol have become available. To assess the airway response to these preparations flow/volume curves in 12 patients with CF (four males, eight females, mean age+/-SD=19.0+/-7.4 yrs) were measured. The tobramycin preparations: Nebicina 2.0 mL (150 mg, containing the preservative phenol), Distobram 3.0 mL (150 mg, containing preservatives), Tobi 5.0 mL (300 mg), Tobi 2.5 mL (150 mg), and Tobi 5.0 mL, were used after bronchodilator application. Immediately and/or 5 min after the tobramycin inhalations there was a significant fall in lung function with the different preparations. There was no significant difference between preparations with and without preservatives/phenol. The bronchial obstruction was comparable to that observed after the inhalation of low-dose tobramycin and after saline. After 10 min of inhalation, the lung function returned to baseline values. Most patients preferred the Tobi 2.5 mL and disliked the Nebicina preparation due to the unpleasant taste. Preceding treatment with bronchodilators prevented the decline in lung function. Assessment of bronchial response at the first nebulisation of high-dose tobramycin and, in case of significant obstruction, beta-agonists in combination with the antibiotic inhalation are recommended." ], "offsets": [ [ 82, 1740 ] ] } ]

[ { "id": "12166559_MESH:D014031_0", "type": "Chemical", "text": [ "tobramycin" ], "offsets": [ [ 51, 61 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D003550_1", "type": "Disease", "text": [ "cystic fibrosis" ], "offsets": [ [ 65, 80 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003550" } ] }, { "id": "12166559_MESH:D014031_2", "type": "Chemical", "text": [ "tobramycin" ], "offsets": [ [ 119, 129 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_287_3", "type": "Species", "text": [ "Pseudomonas-aeruginosa" ], "offsets": [ [ 179, 201 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "287" } ] }, { "id": "12166559_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 211, 219 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12166559_MESH:D003550_5", "type": "Disease", "text": [ "cystic fibrosis" ], "offsets": [ [ 225, 240 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003550" } ] }, { "id": "12166559_MESH:D003550_6", "type": "Disease", "text": [ "CF" ], "offsets": [ [ 242, 244 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003550" } ] }, { "id": "12166559_MESH:D014031_7", "type": "Chemical", "text": [ "tobramycin" ], "offsets": [ [ 302, 312 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D019800_8", "type": "Chemical", "text": [ "phenol" ], "offsets": [ [ 354, 360 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019800" } ] }, { "id": "12166559_MESH:D001982_9", "type": "Disease", "text": [ "bronchial obstruction" ], "offsets": [ [ 380, 401 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001982" } ] }, { "id": "12166559_MESH:D014031_10", "type": "Chemical", "text": [ "tobramycin" ], "offsets": [ [ 423, 433 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D019800_11", "type": "Chemical", "text": [ "phenol" ], "offsets": [ [ 478, 484 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019800" } ] }, { "id": "12166559_9606_12", "type": "Species", "text": [ "patients" ], "offsets": [ [ 585, 593 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12166559_MESH:D003550_13", "type": "Disease", "text": [ "CF" ], "offsets": [ [ 599, 601 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003550" } ] }, { "id": "12166559_MESH:D014031_14", "type": "Chemical", "text": [ "tobramycin" ], "offsets": [ [ 679, 689 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D014031_15", "type": "Chemical", "text": [ "Nebicina" ], "offsets": [ [ 704, 712 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D019800_16", "type": "Chemical", "text": [ "phenol" ], "offsets": [ [ 757, 763 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019800" } ] }, { "id": "12166559_-_17", "type": "Chemical", "text": [ "Distobram" ], "offsets": [ [ 766, 775 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "12166559_MESH:D014031_18", "type": "Chemical", "text": [ "Tobi" ], "offsets": [ [ 819, 823 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D014031_19", "type": "Chemical", "text": [ "Tobi" ], "offsets": [ [ 841, 845 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D014031_20", "type": "Chemical", "text": [ "Tobi" ], "offsets": [ [ 867, 871 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D014031_21", "type": "Chemical", "text": [ "tobramycin" ], "offsets": [ [ 959, 969 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D019800_22", "type": "Chemical", "text": [ "phenol" ], "offsets": [ [ 1149, 1155 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019800" } ] }, { "id": "12166559_MESH:D001982_23", "type": "Disease", "text": [ "bronchial obstruction" ], "offsets": [ [ 1161, 1182 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001982" } ] }, { "id": "12166559_MESH:D014031_24", "type": "Chemical", "text": [ "tobramycin" ], "offsets": [ [ 1248, 1258 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_9606_25", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1357, 1365 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12166559_MESH:D014031_26", "type": "Chemical", "text": [ "tobramycin" ], "offsets": [ [ 1612, 1622 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014031" } ] }, { "id": "12166559_MESH:D000402_27", "type": "Disease", "text": [ "obstruction" ], "offsets": [ [ 1651, 1662 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000402" } ] } ]

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[ { "id": "16603310_title", "type": "title", "text": [ "Decoloration of aqueous Brilliant Green by using glow discharge electrolysis." ], "offsets": [ [ 0, 77 ] ] }, { "id": "16603310_abstract", "type": "abstract", "text": [ "This paper described a plasma degradation of Brilliant Green (BG) by glow discharge electrolysis. Various influencing factors such as the voltage, the distance between cathode and anode were examined. Ultraviolet (UV) absorption spectra, gas chromatogram-mass spectrum (GC-MS), and chemical oxygen demand (COD) were used to monitor the degradation process and to identify the major oxidation intermediates. It was confirmed that benzoic acid, 1,2,3,4,5,6-cyclohexanehexaol, and carboxylic acids (e.g., oxalic acid, succinic acid and hydroxyacetic acid) were produced in the degradation process. The results showed that BG rapidly underwent degradation and eventually mineralized into CO(2) and H(2)O." ], "offsets": [ [ 78, 778 ] ] } ]

[ { "id": "16603310_MESH:C006798_0", "type": "Chemical", "text": [ "Brilliant Green" ], "offsets": [ [ 24, 39 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C006798" } ] }, { "id": "16603310_MESH:C006798_1", "type": "Chemical", "text": [ "Brilliant Green" ], "offsets": [ [ 123, 138 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C006798" } ] }, { "id": "16603310_MESH:C006798_2", "type": "Chemical", "text": [ "BG" ], "offsets": [ [ 140, 142 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C006798" } ] }, { "id": "16603310_MESH:D010100_3", "type": "Chemical", "text": [ "oxygen" ], "offsets": [ [ 369, 375 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010100" } ] }, { "id": "16603310_MESH:D019817_4", "type": "Chemical", "text": [ "benzoic acid" ], "offsets": [ [ 507, 519 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019817" } ] }, { "id": "16603310_-_5", "type": "Chemical", "text": [ "1,2,3,4,5,6-cyclohexanehexaol" ], "offsets": [ [ 521, 550 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16603310_MESH:D002264_6", "type": "Chemical", "text": [ "carboxylic acids" ], "offsets": [ [ 556, 572 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002264" } ] }, { "id": "16603310_MESH:D019815_7", "type": "Chemical", "text": [ "oxalic acid" ], "offsets": [ [ 580, 591 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019815" } ] }, { "id": "16603310_MESH:D019802_8", "type": "Chemical", "text": [ "succinic acid" ], "offsets": [ [ 593, 606 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019802" } ] }, { "id": "16603310_MESH:C031149_9", "type": "Chemical", "text": [ "hydroxyacetic acid" ], "offsets": [ [ 611, 629 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C031149" } ] }, { "id": "16603310_MESH:C006798_10", "type": "Chemical", "text": [ "BG" ], "offsets": [ [ 697, 699 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C006798" } ] }, { "id": "16603310_MESH:D002245_11", "type": "Chemical", "text": [ "CO(2)" ], "offsets": [ [ 762, 767 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "16603310_-_12", "type": "Chemical", "text": [ "H(2)O" ], "offsets": [ [ 772, 777 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "31430015_title", "type": "title", "text": [ "Combined pulsed dye laser and Q-switched Nd:YAG laser intraumatic facial tattoo removal: A case series." ], "offsets": [ [ 0, 103 ] ] }, { "id": "31430015_abstract", "type": "abstract", "text": [ "Traumatic tattoos can be treated with several methods, including mechanical and chemical devices. However, they are rarely used due to the high risk of permanent side effects such as scarring and depigmentation. Recently, laser devices, especially the Q-switched (QS) laser and the pulsed dye laser (PDL), applied in combination, have achieved complete clearance of the lesions without any risk of side effects. Herein, we reported three cases of traumatic facial tattoos successfully treated with combined PDL and QS Nd:YAG laser." ], "offsets": [ [ 104, 635 ] ] } ]

[ { "id": "31430015_MESH:C567128_0", "type": "Disease", "text": [ "intraumatic facial tattoo removal" ], "offsets": [ [ 54, 87 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C567128" } ] }, { "id": "31430015_MESH:C567128_1", "type": "Disease", "text": [ "traumatic facial tattoos" ], "offsets": [ [ 551, 575 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C567128" } ] } ]

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[ { "id": "1207122_title", "type": "title", "text": [ "A model for lliofemoral thrombophlebitis." ], "offsets": [ [ 0, 41 ] ] }, { "id": "1207122_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 42, 42 ] ] } ]

[ { "id": "1207122_MESH:D013924_0", "type": "Disease", "text": [ "lliofemoral thrombophlebitis" ], "offsets": [ [ 12, 40 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013924" } ] } ]

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[ { "id": "22278847_title", "type": "title", "text": [ "Strong electronic and counterion effects on geminal digold formation and reactivity as revealed by gold(I)-aryl model complexes." ], "offsets": [ [ 0, 128 ] ] }, { "id": "22278847_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 129, 129 ] ] } ]

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[ { "id": "1672482_title", "type": "title", "text": [ "Hemodynamic and neurohormonal effects of quinidine in patients with severe left ventricular dysfunction secondary to coronary artery disease or idiopathic dilated cardiomyopathy." ], "offsets": [ [ 0, 178 ] ] }, { "id": "1672482_abstract", "type": "abstract", "text": [ "Quinidine causes vasodilation directly and by inhibition of adrenergic vasoconstriction, but it also exerts negative inotropic activity. Although this drug is often administered to patients with severe congestive heart failure, the net consequences of these opposing actions have not been evaluated in such patients. The hemodynamic and neurohormonal response to oral quinidine (600 mg) in 19 patients with severe chronic heart failure was therefore determined. Vasodilation was the predominant effect of quinidine, with reductions in mean arterial, left ventricular filling and right atrial pressures of -9% (confidence interval [CI] -5 to -13), -8% (CI -19 to 3), -15% (CI -26 to -4), respectively. The quinidine-induced vasodilation increased plasma norepinephrine and epinephrine concentrations by 44% (CI +17 to +72) and 47% (CI +2 to +91), respectively. No change in cardiac performance was noted, with the cardiac index slightly increased (+10%, CI +2 to +17) and stroke work index unchanged (0%, CI -11 to +11) after quinidine. Although the mean serum quinidine concentration was within the therapeutic range or lower in all patients, the serum quinidine concentration and the change in mean arterial pressure did correlate (r2 = 0.64). In conclusion, vasodilation is the predominant hemodynamic effect of oral quinidine in patients with congestive heart failure. However, potential adverse effects may be caused by consequent neurohormonal activation." ], "offsets": [ [ 179, 1639 ] ] } ]

[ { "id": "1672482_MESH:D011802_0", "type": "Chemical", "text": [ "quinidine" ], "offsets": [ [ 41, 50 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 54, 62 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "1672482_MESH:D018754_2", "type": "Disease", "text": [ "ventricular dysfunction" ], "offsets": [ [ 80, 103 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018754" } ] }, { "id": "1672482_MESH:D003324_3", "type": "Disease", "text": [ "coronary artery disease" ], "offsets": [ [ 117, 140 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003324" } ] }, { "id": "1672482_MESH:C536277_4", "type": "Disease", "text": [ "idiopathic dilated cardiomyopathy" ], "offsets": [ [ 144, 177 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C536277" } ] }, { "id": "1672482_MESH:D011802_5", "type": "Chemical", "text": [ "Quinidine" ], "offsets": [ [ 179, 188 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 360, 368 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "1672482_MESH:D006333_7", "type": "Disease", "text": [ "congestive heart failure" ], "offsets": [ [ 381, 405 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006333" } ] }, { "id": "1672482_9606_8", "type": "Species", "text": [ "patients" ], "offsets": [ [ 486, 494 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "1672482_MESH:D011802_9", "type": "Chemical", "text": [ "quinidine" ], "offsets": [ [ 547, 556 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 572, 580 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "1672482_MESH:D006333_11", "type": "Disease", "text": [ "heart failure" ], "offsets": [ [ 601, 614 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006333" } ] }, { "id": "1672482_MESH:D011802_12", "type": "Chemical", "text": [ "quinidine" ], "offsets": [ [ 684, 693 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_MESH:D014693_13", "type": "Disease", "text": [ "ventricular filling" ], "offsets": [ [ 734, 753 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014693" } ] }, { "id": "1672482_MESH:D011802_14", "type": "Chemical", "text": [ "quinidine" ], "offsets": [ [ 884, 893 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_MESH:D009638_15", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 932, 946 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009638" } ] }, { "id": "1672482_MESH:D004837_16", "type": "Chemical", "text": [ "epinephrine" ], "offsets": [ [ 951, 962 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004837" } ] }, { "id": "1672482_MESH:D020521_17", "type": "Disease", "text": [ "stroke" ], "offsets": [ [ 1150, 1156 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020521" } ] }, { "id": "1672482_MESH:D011802_18", "type": "Chemical", "text": [ "quinidine" ], "offsets": [ [ 1204, 1213 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_MESH:D011802_19", "type": "Chemical", "text": [ "quinidine" ], "offsets": [ [ 1239, 1248 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_9606_20", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1312, 1320 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "1672482_MESH:D011802_21", "type": "Chemical", "text": [ "quinidine" ], "offsets": [ [ 1332, 1341 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_MESH:D011802_22", "type": "Chemical", "text": [ "quinidine" ], "offsets": [ [ 1498, 1507 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011802" } ] }, { "id": "1672482_9606_23", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1511, 1519 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "1672482_MESH:D006333_24", "type": "Disease", "text": [ "congestive heart failure" ], "offsets": [ [ 1525, 1549 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006333" } ] } ]

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[ { "id": "27835_title", "type": "title", "text": [ "Use of antianxiety agents in anxious outpatients." ], "offsets": [ [ 0, 49 ] ] }, { "id": "27835_abstract", "type": "abstract", "text": [ "The present paper reviews the role of antianxiety agents in the treatment of nonpsychotic anxious patients. Major emphasis is placed on findings from clinical trials conducted by this research group. Consideration is given to the relative efficacy of available antianxiety agents, to patients response in relation to patterns of symptomatology, and to the degree of symptom relief experienced by drug-treated anxious patients. Also discussed are some of the many nonspecific factors that affect improvement with drug treatment in general and with the benzodiazepines in particular. It is concluded that many anxious patients are not currently receiving adequate drug treatment, and may require longer periods of drug therapy or supplemental nondrug intervention." ], "offsets": [ [ 50, 812 ] ] } ]

[ { "id": "27835_MESH:D001007_0", "type": "Disease", "text": [ "anxious" ], "offsets": [ [ 29, 36 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001007" } ] }, { "id": "27835_MESH:D019965_1", "type": "Disease", "text": [ "nonpsychotic anxious" ], "offsets": [ [ 127, 147 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019965" } ] }, { "id": "27835_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 148, 156 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27835_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 334, 342 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27835_MESH:D001007_4", "type": "Disease", "text": [ "anxious" ], "offsets": [ [ 459, 466 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001007" } ] }, { "id": "27835_9606_5", "type": "Species", "text": [ "patients" ], "offsets": [ [ 467, 475 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27835_MESH:D001569_6", "type": "Chemical", "text": [ "benzodiazepines" ], "offsets": [ [ 601, 616 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001569" } ] }, { "id": "27835_MESH:D001007_7", "type": "Disease", "text": [ "anxious" ], "offsets": [ [ 658, 665 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001007" } ] }, { "id": "27835_9606_8", "type": "Species", "text": [ "patients" ], "offsets": [ [ 666, 674 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "35617497_title", "type": "title", "text": [ "[Family Approaches in Early Intervention: Benchmarks to Guide Intervention and Support Families in First Episode Psychosis Programs (FEPP)]." ], "offsets": [ [ 0, 140 ] ] }, { "id": "35617497_abstract", "type": "abstract", "text": [ "There is now broad consensus on the usefulness of family approaches in early intervention programs. The evolution of knowledge about early psychosis and the development of family interventions have greatly influenced the perception of families in the recovery process. Objectives This article proposes a state of knowledge of family intervention practices by looking at family involvement in early intervention. Knowledge from the family journey constitutes the historical basis of the article, while more recent knowledge about psychotic disorders and family intervention form the basis of the article's content. The objectives are to: 1) document the specific impacts and needs of families during a first episode of psychosis (FEP); 2) review the main approaches in family intervention; 3) guide the application of family interventions in FEP programs and 4) raise issues related to family involvement in early intervention. Method Historical knowledge on the development of family intervention approaches in mental health was documented from the work of pioneers in the field of family intervention, while the state of current practices has been the subject of a literature review (intervention models and approaches, effectiveness of interventions, issues of intervention and family involvement, etc.). Results from recent studies conducted in Quebec and elsewhere provide an overview of intervention methods and the contribution of families in early intervention teams. Issues related to the establishment of collaborative practices, information sharing and respect for confidentiality in mental health are addressed. Results Knowledge from the literature review and recent research is highlighted in relation to the First Episode Psychosis Intervention Programs Framework (Cadre PPEP, 2018) and the Mental Health Action Plan measures (PASM 2015-2020), as well as to international best practice guidelines for early intervention. They identify what has been achieved as well as ways to move forward in order to continue developing family intervention practices in Quebec. Conclusion Recognition of the essential role of families and their involvement in early intervention presents challenges. While family interventions have demonstrated their effectiveness, both for the person with the disorder and for their family, actions must be taken to support the implementation of these practices and ensure their sustainability in early intervention teams." ], "offsets": [ [ 141, 2597 ] ] } ]

[ { "id": "35617497_MESH:D011605_0", "type": "Disease", "text": [ "Psychosis" ], "offsets": [ [ 113, 122 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011605" } ] }, { "id": "35617497_MESH:D011605_1", "type": "Disease", "text": [ "psychosis" ], "offsets": [ [ 280, 289 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011605" } ] }, { "id": "35617497_MESH:D011618_2", "type": "Disease", "text": [ "psychotic disorders" ], "offsets": [ [ 670, 689 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011618" } ] }, { "id": "35617497_MESH:D011605_3", "type": "Disease", "text": [ "psychosis" ], "offsets": [ [ 859, 868 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011605" } ] }, { "id": "35617497_MESH:D011605_4", "type": "Disease", "text": [ "Psychosis" ], "offsets": [ [ 1877, 1886 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011605" } ] } ]

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[ { "id": "2059603_title", "type": "title", "text": [ "Early identification of placenta praevia." ], "offsets": [ [ 0, 41 ] ] }, { "id": "2059603_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 42, 42 ] ] } ]

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[ { "id": "30265395_title", "type": "title", "text": [ "Virtual reality may prove useful for surgical fire education and training." ], "offsets": [ [ 0, 74 ] ] }, { "id": "30265395_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 75, 75 ] ] } ]

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[ { "id": "23153017_title", "type": "title", "text": [ "Assessment of hemodynamic efficacy and safety of 6% hydroxyethyl starch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: how to guide fluid therapy?" ], "offsets": [ [ 0, 171 ] ] }, { "id": "23153017_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 172, 172 ] ] } ]

[ { "id": "23153017_-_0", "type": "Chemical", "text": [ "hydroxyethyl starch" ], "offsets": [ [ 52, 71 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "23153017_-_1", "type": "Chemical", "text": [ "NaCl fluid" ], "offsets": [ [ 89, 99 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "23153017_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 115, 123 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "23153017_MESH:D018805_3", "type": "Disease", "text": [ "sepsis" ], "offsets": [ [ 136, 142 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018805" } ] } ]

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[ { "id": "34935715_title", "type": "title", "text": [ "Coverage, Payment, and the Impact of Advocacy." ], "offsets": [ [ 0, 46 ] ] }, { "id": "34935715_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 47, 47 ] ] } ]

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[ { "id": "21323930_title", "type": "title", "text": [ "Single subcutaneous dosing of cefovecin in rhesus monkeys (Macaca mulatta): a pharmacokinetic study." ], "offsets": [ [ 0, 100 ] ] }, { "id": "21323930_abstract", "type": "abstract", "text": [ "Cefovecin is a third-generation cephalosporin approved for antibacterial treatment with a 14-day dosing interval in dogs and cats. This antibiotic may also be useful for zoo and wildlife veterinary medicine, because of its broad spectrum and long duration of activity. The aim of the study was to determine whether cefovecin is a suitable antibiotic to prevent skin wound infection in rhesus monkeys. Therefore, the pharmacokinetics (PK) of cefovecin after a single subcutaneous injection at 8 mg/kg bodyweight in four rhesus monkeys (Macaca mulatta) and sensitivity of bacterial isolates from fresh skin wounds were determined. After administration, blood, urine, and feces were collected, and concentrations of cefovecin were determined. Further, the minimum inhibitory concentrations (MIC) for bacteria isolated from fresh skin wounds of monkeys during a health control program were determined. The mean maximum plasma concentration (C(max) ) of cefovecin was 78 mug/mL and was achieved after 57 min. The mean apparent long elimination half-life (t1/2) was 6.6 h and excretion occurred mainly via urine. The MIC for the majority of the bacteria examined was >100 mug/mL. The PK of cefovecin in rhesus monkeys is substantially different than for dogs and cats. Cefovecin rapidly reached C(max) which however was lower than most of the MIC levels and with a very short t1/2. Therefore, cefovecin is not recommended for treating skin wounds in rhesus monkeys." ], "offsets": [ [ 101, 1560 ] ] } ]

[ { "id": "21323930_MESH:C516253_0", "type": "Chemical", "text": [ "cefovecin" ], "offsets": [ [ 30, 39 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_9544_1", "type": "Species", "text": [ "rhesus monkeys" ], "offsets": [ [ 43, 57 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9544" } ] }, { "id": "21323930_9544_2", "type": "Species", "text": [ "Macaca mulatta" ], "offsets": [ [ 59, 73 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9544" } ] }, { "id": "21323930_MESH:C516253_3", "type": "Chemical", "text": [ "Cefovecin" ], "offsets": [ [ 101, 110 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_MESH:D002511_4", "type": "Chemical", "text": [ "cephalosporin" ], "offsets": [ [ 133, 146 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002511" } ] }, { "id": "21323930_9615_5", "type": "Species", "text": [ "dogs" ], "offsets": [ [ 217, 221 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] }, { "id": "21323930_9685_6", "type": "Species", "text": [ "cats" ], "offsets": [ [ 226, 230 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9685" } ] }, { "id": "21323930_MESH:C516253_7", "type": "Chemical", "text": [ "cefovecin" ], "offsets": [ [ 416, 425 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_MESH:D007239_8", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 473, 482 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "21323930_9544_9", "type": "Species", "text": [ "rhesus monkeys" ], "offsets": [ [ 486, 500 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9544" } ] }, { "id": "21323930_MESH:C516253_10", "type": "Chemical", "text": [ "cefovecin" ], "offsets": [ [ 542, 551 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_9544_11", "type": "Species", "text": [ "rhesus monkeys" ], "offsets": [ [ 620, 634 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9544" } ] }, { "id": "21323930_9544_12", "type": "Species", "text": [ "Macaca mulatta" ], "offsets": [ [ 636, 650 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9544" } ] }, { "id": "21323930_MESH:C516253_13", "type": "Chemical", "text": [ "cefovecin" ], "offsets": [ [ 814, 823 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_MESH:C516253_14", "type": "Chemical", "text": [ "cefovecin" ], "offsets": [ [ 1050, 1059 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_MESH:C516253_15", "type": "Chemical", "text": [ "cefovecin" ], "offsets": [ [ 1285, 1294 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_9544_16", "type": "Species", "text": [ "rhesus monkeys" ], "offsets": [ [ 1298, 1312 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9544" } ] }, { "id": "21323930_9615_17", "type": "Species", "text": [ "dogs" ], "offsets": [ [ 1349, 1353 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] }, { "id": "21323930_9685_18", "type": "Species", "text": [ "cats" ], "offsets": [ [ 1358, 1362 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9685" } ] }, { "id": "21323930_MESH:C516253_19", "type": "Chemical", "text": [ "Cefovecin" ], "offsets": [ [ 1364, 1373 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_MESH:C516253_20", "type": "Chemical", "text": [ "cefovecin" ], "offsets": [ [ 1488, 1497 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C516253" } ] }, { "id": "21323930_9544_21", "type": "Species", "text": [ "rhesus monkeys" ], "offsets": [ [ 1545, 1559 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9544" } ] } ]

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[ { "id": "8796561_title", "type": "title", "text": [ "Renal, hepatic, and cardiac enhancement on Doppler and gray-scale sonograms obtained with EchoGen." ], "offsets": [ [ 0, 98 ] ] }, { "id": "8796561_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 99, 99 ] ] } ]

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[ { "id": "19238647_title", "type": "title", "text": [ "Comparison of the efficacy between lidocaine spray plus lidocaine jelly lubrication and lidocaine jelly lubrication alone prior to nasogastric intubation: a prospective double-blind randomized controlled study." ], "offsets": [ [ 0, 210 ] ] }, { "id": "19238647_abstract", "type": "abstract", "text": [ "OBJECTIVE: Although a common procedure, nasogastric (NG) intubation is also painful and unsatisfactory. Previous studies showed the benefits of local anesthesia in various forms over lubricant jelly alone, but they are rarely used due to their inconvenience and unavailability. The authors conducted a double-blind randomized controlled study to compare a commercial-available 10% lidocaine spray plus 2% lidocaine jelly lubrication and 2% lidocaine jelly lubrication alone prior to NG intubation. MATERIAL AND METHOD: Patients who fulfilled the indications for NG intubation were randomized to receive either 10% lidocaine spray or placebo (normal saline) spray to the nostril and throat prior to NG intubation. NG tubes lubricated with 2% lidocaine jelly were then inserted by experienced physicians. Physician, who sprayed, inserted the NG tubes and collected the patient's data, did not know the content of the spray, while patients were also blinded against the information of the spray. RESULTS: Sixty patients were included in the present study. Thirty one randomly received lidocaine spray and 29 received placebo spray. There were more female patients in the lidocaine group (65% vs. 28%, p=0.04), but ages, indications for NG intubation, size of NG tube, and physicians' experience in the procedure were similar in both groups. Patients' discomfort after being sprayed was also similar in both groups. However during the NG intubation, the patients in the lidocaine group experienced less pain as measured by visual analog scale (23.6 +/- 16.6 vs. 43.1 +/- 31.4 mm, p=0.005) and less discomfort (30.0 +/- 24.4 vs. 51.4 +/- 30.0 mm, p=0.004) than the placebo group. Ninety-three percent of the patients in the lidocaine group favored the same spray for their next intubations, while 65% of the placebo group did (p = 0.009). In addition, there was more physicians' satisfaction in the lidocaine group as measured by 5-point Likert scale (p=0.041). Likewise, 61% of the physicians favored lidocaine spray compared to 34.5% of the placebo spray (p=0.038). Degree of difficulty, duration of intubation, number of attempts and success rates of NG intubations were as well similar in both groups. No complications were found in the present study. CONCLUSION: 10% lidocaine spray plus 2% lidocaine jelly lubrication was more effective in relieving patients' pain, discomfort, and resulted in higher physicians' satisfaction. There were also no additional side effects as compared to 2% lidocaine jelly lubrication alone. Therefore, it should be recommended for routine application." ], "offsets": [ [ 211, 2795 ] ] } ]

[ { "id": "19238647_MESH:D008012_0", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 35, 44 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_1", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 56, 65 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_2", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 88, 97 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D010146_3", "type": "Disease", "text": [ "painful" ], "offsets": [ [ 287, 294 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "19238647_-_4", "type": "Chemical", "text": [ "lubricant jelly" ], "offsets": [ [ 394, 409 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "19238647_MESH:D008012_5", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 592, 601 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_6", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 616, 625 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_7", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 651, 660 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_9606_8", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 730, 738 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_MESH:D008012_9", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 825, 834 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_10", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 952, 961 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_9606_11", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1078, 1085 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_9606_12", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1139, 1147 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_9606_13", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1219, 1227 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_MESH:D008012_14", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 1293, 1302 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_9606_15", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1363, 1371 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_MESH:D008012_16", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 1379, 1388 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_9606_17", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 1549, 1557 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_9606_18", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1661, 1669 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_MESH:D008012_19", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 1677, 1686 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D010146_20", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 1710, 1714 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "19238647_9606_21", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1914, 1922 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_MESH:D008012_22", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 1930, 1939 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_23", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 2105, 2114 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_24", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 2208, 2217 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_25", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 2478, 2487 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_MESH:D008012_26", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 2502, 2511 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "19238647_9606_27", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2562, 2570 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19238647_MESH:D010146_28", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 2572, 2576 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "19238647_MESH:D008012_29", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 2700, 2709 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] } ]

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[ { "id": "16524439_title", "type": "title", "text": [ "The capsaicin cough reflex in eczema patients with respiratory symptoms elicited by perfume." ], "offsets": [ [ 0, 92 ] ] }, { "id": "16524439_abstract", "type": "abstract", "text": [ "Respiratory symptoms elicited by perfume are common in the population but have unclear pathophysiology. Increased capsaicin cough responsiveness has been associated with the symptoms, but it is unknown whether the site of the symptoms in the airways influences this association. The aim of this study was to investigate the association between the site of airway symptoms elicited by perfume and cough responsiveness to bronchial challenge with capsaicin. 21 eczema patients with respiratory symptoms elicited by perfume were compared with 21 healthy volunteers in a sex- and age-matched case control study. The participants completed a symptom questionnaire and underwent a bronchial challenge with capsaicin. Lower, but not upper, respiratory symptoms elicited by perfume were associated with increased capsaicin cough responsiveness. Having severe symptoms to perfume (n=11) did not relate to the site of the symptoms in the airways and was not associated with increased capsaicin cough responsiveness. In conclusion, respiratory symptoms elicited by perfume may reflect local hyperreactivity related to defensive reflexes in the airways, and measurements of the capsaicin cough reflex are relevant when patients with lower respiratory symptoms related to environmental perfume exposures are investigated." ], "offsets": [ [ 93, 1401 ] ] } ]

[ { "id": "16524439_MESH:D002211_0", "type": "Chemical", "text": [ "capsaicin" ], "offsets": [ [ 4, 13 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002211" } ] }, { "id": "16524439_MESH:D003371_1", "type": "Disease", "text": [ "cough" ], "offsets": [ [ 14, 19 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003371" } ] }, { "id": "16524439_MESH:D004485_2", "type": "Disease", "text": [ "eczema" ], "offsets": [ [ 30, 36 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004485" } ] }, { "id": "16524439_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 37, 45 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16524439_MESH:D012818_4", "type": "Disease", "text": [ "respiratory symptoms" ], "offsets": [ [ 51, 71 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012818" } ] }, { "id": "16524439_MESH:D012818_5", "type": "Disease", "text": [ "Respiratory symptoms" ], "offsets": [ [ 93, 113 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012818" } ] }, { "id": "16524439_MESH:D002211_6", "type": "Chemical", "text": [ "capsaicin" ], "offsets": [ [ 207, 216 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002211" } ] }, { "id": "16524439_MESH:D003371_7", "type": "Disease", "text": [ "cough responsiveness" ], "offsets": [ [ 217, 237 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003371" } ] }, { "id": "16524439_MESH:D003371_8", "type": "Disease", "text": [ "cough" ], "offsets": [ [ 489, 494 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003371" } ] }, { "id": "16524439_MESH:D002211_9", "type": "Chemical", "text": [ "capsaicin" ], "offsets": [ [ 538, 547 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002211" } ] }, { "id": "16524439_MESH:D004485_10", "type": "Disease", "text": [ "eczema" ], "offsets": [ [ 552, 558 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004485" } ] }, { "id": "16524439_9606_11", "type": "Species", "text": [ "patients" ], "offsets": [ [ 559, 567 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16524439_MESH:D012818_12", "type": "Disease", "text": [ "respiratory symptoms" ], "offsets": [ [ 573, 593 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012818" } ] }, { "id": "16524439_9606_13", "type": "Species", "text": [ "participants" ], "offsets": [ [ 705, 717 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16524439_MESH:D002211_14", "type": "Chemical", "text": [ "capsaicin" ], "offsets": [ [ 793, 802 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002211" } ] }, { "id": "16524439_MESH:D012818_15", "type": "Disease", "text": [ "respiratory symptoms" ], "offsets": [ [ 826, 846 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012818" } ] }, { "id": "16524439_MESH:D002211_16", "type": "Chemical", "text": [ "capsaicin" ], "offsets": [ [ 898, 907 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002211" } ] }, { "id": "16524439_MESH:D003371_17", "type": "Disease", "text": [ "cough" ], "offsets": [ [ 908, 913 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003371" } ] }, { "id": "16524439_MESH:D002211_18", "type": "Chemical", "text": [ "capsaicin" ], "offsets": [ [ 1067, 1076 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002211" } ] }, { "id": "16524439_MESH:D003371_19", "type": "Disease", "text": [ "cough" ], "offsets": [ [ 1077, 1082 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003371" } ] }, { "id": "16524439_MESH:D012818_20", "type": "Disease", "text": [ "respiratory symptoms" ], "offsets": [ [ 1114, 1134 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012818" } ] }, { "id": "16524439_MESH:D002211_21", "type": "Chemical", "text": [ "capsaicin" ], "offsets": [ [ 1259, 1268 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002211" } ] }, { "id": "16524439_MESH:D003371_22", "type": "Disease", "text": [ "cough" ], "offsets": [ [ 1269, 1274 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003371" } ] }, { "id": "16524439_9606_23", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1300, 1308 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16524439_MESH:D012818_24", "type": "Disease", "text": [ "respiratory symptoms" ], "offsets": [ [ 1320, 1340 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012818" } ] } ]

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[ { "id": "1593616_title", "type": "title", "text": [ "Inwardly rectifying potassium current in rabbit osteoclasts: a whole-cell and single-channel study." ], "offsets": [ [ 0, 99 ] ] }, { "id": "1593616_abstract", "type": "abstract", "text": [ "Ionic conductances of rabbit osteoclasts were investigated using both whole-cell and cell-attached configurations of the patch-clamp recording technique. The predominant conductance found in these cells was an inwardly rectifying K+ conductance. Whole-cell currents showed an N-shaped current-voltage (I-V) relation with inward current activated at potentials negative to EK. When external K+ was varied, I-V curves shifted 53 mV/10-fold change in [K+]out, as predicted for a K(+)-selective channel. Inward current was blocked by Ba2+ and showed a time-dependent decline at negative potentials, which was reduced in Na(+)-free external solution. Inward single-channel currents were recorded in the cell-attached configuration. Single-channel currents were identified as inward-rectifier K+ channels based on the following observations: (i) Unitary I-V relations rectified, with only inward current resolved. (ii) Unitary conductance (gamma) was 31 pS when recorded in the cell-attached configuration with 140 mM K+ in the pipette and was found to be dependent on [K+]. (iii) Addition of Ba2+ to the pipette solution abolished single-channel events. We conclude that rabbit osteoclasts possess inwardly rectifying K+ channels which give rise to the inward current recorded at negative potentials in the whole-cell configuration. This inwardly rectifying K+ current may be responsible for setting the resting membrane potential and for dissipating electrical potential differences which arise from electrogenic transport of protons across the osteoclast ruffled border." ], "offsets": [ [ 100, 1667 ] ] } ]

[ { "id": "1593616_MESH:D011188_0", "type": "Chemical", "text": [ "potassium" ], "offsets": [ [ 20, 29 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011188" } ] }, { "id": "1593616_MESH:C080430_1", "type": "Chemical", "text": [ "Ba2+" ], "offsets": [ [ 630, 634 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C080430" } ] }, { "id": "1593616_MESH:C080430_2", "type": "Chemical", "text": [ "Ba2+" ], "offsets": [ [ 1187, 1191 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C080430" } ] } ]

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[ { "id": "36329598_title", "type": "title", "text": [ "An objective comparison of two pulse oximetry sensors with different adhesive systems on healthy human volunteers based on biophysical assessments." ], "offsets": [ [ 0, 147 ] ] }, { "id": "36329598_abstract", "type": "abstract", "text": [ "BACKGROUND: Medical Adhesive Related Skin Injuries can arise from topically applied medical devices, especially in those with fragile skin, including the elderly and premature infants. The purpose of this study was to compare gentleness and reapplication of two pulse oximetry sensors (OxySoftN and MaxN, Medtronic, Boulder, CO). MATERIALS AND METHODS: Eighteen healthy subjects aged 65 years and older were enrolled in the gentleness trial, and 20 healthy subjects (18-69 years) were enrolled in the reapplication trial. For the gentleness trial, trans-epidermal water loss (TEWL) measurements were made at five sites on each forearm at three time points (baseline [T0], 4-h postinitial wear [T1], 4-h postsecond wear [T2]). Total amount of protein adhered to each device was also determined. For the reapplication trial, a series of 180 peel tests were performed to observe the forces required to detach the sensor from the skin. RESULTS: TEWL rates in the tail region were significantly greater with MaxN compared to OxySoftN at T1 (p < 0.05). Both were significantly greater than control (p < 0.05). Further, protein analysis revealed that the amount of protein removed was significantly less with OxySoftN compared to MaxN (p < < 0.0001). Differences in loss of adhesion of the tail region between the two sensors were demonstrated, with OxySoftN depreciating at a much slower rate compared with MaxN. CONCLUSION: The OxySoftN sensor appears to be gentle, even on fragile skin, based on reduced strain on the skin during removal. Further, it demonstrated the ability to withstand several reapplications without functional loss in adhesion." ], "offsets": [ [ 148, 1793 ] ] } ]

[ { "id": "36329598_9606_0", "type": "Species", "text": [ "human" ], "offsets": [ [ 97, 102 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36329598_MESH:C536183_1", "type": "Disease", "text": [ "fragile skin" ], "offsets": [ [ 274, 286 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C536183" } ] }, { "id": "36329598_9606_2", "type": "Species", "text": [ "infants" ], "offsets": [ [ 324, 331 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36329598_MESH:D002245_3", "type": "Chemical", "text": [ "CO" ], "offsets": [ [ 473, 475 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "36329598_MESH:C536183_4", "type": "Disease", "text": [ "fragile skin" ], "offsets": [ [ 1618, 1630 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C536183" } ] } ]

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[ { "id": "1627665_title", "type": "title", "text": [ "Substance abuse prevention: competence enhancement and the development of positive life options." ], "offsets": [ [ 0, 96 ] ] }, { "id": "1627665_abstract", "type": "abstract", "text": [ "Recent advances in the field of substance abuse prevention have derived from a consideration of the etiology of substance use and have also been solidly grounded in psychological theory. Evaluation studies of psychosocial prevention interventions have become increasingly rigorous, and clearly demonstrate that there are effective approaches to prevention. The Life Skills Training Program is an example of a competence enhancement approach to substance abuse prevention. While research with this approach demonstrates its effectiveness at reducing substance use behavior, experience working with disadvantaged youth suggests the need to broaden the concept of competence enhancement. Specifically, recommendations are made for formalizing the concept of positive life options as a potentially important component of substance abuse prevention." ], "offsets": [ [ 97, 941 ] ] } ]

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[ { "id": "5140792_title", "type": "title", "text": [ "[Chronic active hepatitis]." ], "offsets": [ [ 0, 27 ] ] }, { "id": "5140792_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 28, 28 ] ] } ]

[ { "id": "5140792_MESH:D006505_0", "type": "Disease", "text": [ "Chronic active hepatitis" ], "offsets": [ [ 1, 25 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006505" } ] } ]

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[ { "id": "19732820_title", "type": "title", "text": [ "Lack of association between plasma dehydroepiandrosterone sulfate (DHEA-S) levels and depression in hemodialysis patients: a cross-sectional study." ], "offsets": [ [ 0, 147 ] ] }, { "id": "19732820_abstract", "type": "abstract", "text": [ "OBJECTIVE: Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis patients has not been established. METHOD: We conducted a cross-sectional study, in which 80 patients under regular hemodialysis were studied, and their serum DHEA-S levels were analyzed. RESULTS: The prevalence of depression in our studied hemodialysis population is 37.5% (30/80). The DHEA-S level was 1138.1+/-1216.9 ng/mL in male patients and 502.1+/-389.4 ng/mL in female patients. The levels were not significantly different between patients with or without depression (910.8+/-1127.1 ng/mL vs. 769.3+/-848.3 ng/mL, P=0.533). As compared to the non-depressed patients, the depressed patients were more likely to be male, with lower body mass index, consuming more alcohol, and with more co-morbidity. The prevalence of depression was not associated with age, educational background, smoking, duration of dialysis, hemoglobin, albumin, CRP, ferritin, and urea clearance (Kt/V and URR). The serum DHEA-S levels exhibited significant and independent associations with age, gender, diabetes mellitus, and the levels of serum albumin. CONCLUSION: The study suggested a lack of association between plasma DHEA-S levels and depression in hemodialysis patients." ], "offsets": [ [ 148, 1624 ] ] } ]

[ { "id": "19732820_MESH:D019314_0", "type": "Chemical", "text": [ "dehydroepiandrosterone sulfate" ], "offsets": [ [ 35, 65 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019314" } ] }, { "id": "19732820_MESH:D019314_1", "type": "Chemical", "text": [ "DHEA-S" ], "offsets": [ [ 67, 73 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019314" } ] }, { "id": "19732820_MESH:D000275_2", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 86, 96 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 113, 121 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_MESH:D000275_4", "type": "Disease", "text": [ "Depression" ], "offsets": [ [ 159, 169 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_9606_5", "type": "Species", "text": [ "patients" ], "offsets": [ [ 196, 204 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_MESH:D019314_6", "type": "Chemical", "text": [ "DHEA-S" ], "offsets": [ [ 214, 220 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019314" } ] }, { "id": "19732820_MESH:D000275_7", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 266, 276 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_9606_8", "type": "Species", "text": [ "patients" ], "offsets": [ [ 377, 385 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_MESH:D019314_9", "type": "Chemical", "text": [ "DHEA-S" ], "offsets": [ [ 420, 426 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019314" } ] }, { "id": "19732820_MESH:D000275_10", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 438, 448 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_9606_11", "type": "Species", "text": [ "patients" ], "offsets": [ [ 465, 473 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_9606_12", "type": "Species", "text": [ "patients" ], "offsets": [ [ 558, 566 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_MESH:D019314_13", "type": "Chemical", "text": [ "DHEA-S" ], "offsets": [ [ 624, 630 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019314" } ] }, { "id": "19732820_MESH:D000275_14", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 680, 690 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_MESH:D019314_15", "type": "Chemical", "text": [ "DHEA-S" ], "offsets": [ [ 752, 758 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019314" } ] }, { "id": "19732820_9606_16", "type": "Species", "text": [ "patients" ], "offsets": [ [ 799, 807 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_9606_17", "type": "Species", "text": [ "patients" ], "offsets": [ [ 842, 850 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_9606_18", "type": "Species", "text": [ "patients" ], "offsets": [ [ 904, 912 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_MESH:D000275_19", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 929, 939 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_MESH:D000275_20", "type": "Disease", "text": [ "depressed" ], "offsets": [ [ 1020, 1029 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_9606_21", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1030, 1038 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_MESH:D000275_22", "type": "Disease", "text": [ "depressed" ], "offsets": [ [ 1044, 1053 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_9606_23", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1054, 1062 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19732820_MESH:D000438_24", "type": "Chemical", "text": [ "alcohol" ], "offsets": [ [ 1135, 1142 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000438" } ] }, { "id": "19732820_MESH:D000275_25", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 1190, 1200 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_213_26", "type": "Gene", "text": [ "albumin" ], "offsets": [ [ 1297, 1304 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "213" } ] }, { "id": "19732820_1401_27", "type": "Gene", "text": [ "CRP" ], "offsets": [ [ 1306, 1309 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1401" } ] }, { "id": "19732820_MESH:D014508_28", "type": "Chemical", "text": [ "urea" ], "offsets": [ [ 1325, 1329 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014508" } ] }, { "id": "19732820_MESH:D019314_29", "type": "Chemical", "text": [ "DHEA-S" ], "offsets": [ [ 1366, 1372 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019314" } ] }, { "id": "19732820_MESH:D003920_30", "type": "Disease", "text": [ "diabetes mellitus" ], "offsets": [ [ 1449, 1466 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "19732820_213_31", "type": "Gene", "text": [ "albumin" ], "offsets": [ [ 1492, 1499 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "213" } ] }, { "id": "19732820_MESH:D019314_32", "type": "Chemical", "text": [ "DHEA-S" ], "offsets": [ [ 1570, 1576 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019314" } ] }, { "id": "19732820_MESH:D000275_33", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 1588, 1598 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "19732820_9606_34", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1615, 1623 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "3429373_title", "type": "title", "text": [ "Metronidazole and spiramycin in abscesses caused by Bacteroides spp. and Staphylococcus aureus in mice." ], "offsets": [ [ 0, 103 ] ] }, { "id": "3429373_abstract", "type": "abstract", "text": [ "The activity of metronidazole and spiramycin, singly or in combination, was tested in vitro and also in vivo, in the eradication of infection caused by Bacteroides spp. and Staphylococcus aureus, alone or in combination. The MICs of metronidazole for the B. melaninogenicus and B. fragilis strains were significantly reduced by the addition of spiramycin (from 0.25 and 0.5 mg/l, to 0.062 and 0.125 mg/l, respectively). Antimicrobial synergy between metronidazole and spiramycin was noted against Bacteroides spp. in abscesses caused in mice by subcutaneous injection of Bacteroides spp. alone or in combination with S. aureus. Furthermore, an additional reduction in the number of S. aureus was noted in mixed infections with bacteroides that were treated with metronidazole alone. The antimicrobial synergy in vitro and in vivo between metronidazole and spiramycin may have clinical implications that deserve to be further investigated." ], "offsets": [ [ 104, 1042 ] ] } ]

[ { "id": "3429373_MESH:D008795_0", "type": "Chemical", "text": [ "Metronidazole" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008795" } ] }, { "id": "3429373_MESH:D015572_1", "type": "Chemical", "text": [ "spiramycin" ], "offsets": [ [ 18, 28 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015572" } ] }, { "id": "3429373_29523_2", "type": "Species", "text": [ "Bacteroides spp" ], "offsets": [ [ 52, 67 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "29523" } ] }, { "id": "3429373_1280_3", "type": "Species", "text": [ "Staphylococcus aureus" ], "offsets": [ [ 73, 94 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1280" } ] }, { "id": "3429373_10090_4", "type": "Species", "text": [ "mice" ], "offsets": [ [ 98, 102 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "3429373_MESH:D008795_5", "type": "Chemical", "text": [ "metronidazole" ], "offsets": [ [ 120, 133 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008795" } ] }, { "id": "3429373_MESH:D015572_6", "type": "Chemical", "text": [ "spiramycin" ], "offsets": [ [ 138, 148 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015572" } ] }, { "id": "3429373_MESH:D007239_7", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 236, 245 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "3429373_29523_8", "type": "Species", "text": [ "Bacteroides spp" ], "offsets": [ [ 256, 271 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "29523" } ] }, { "id": "3429373_1280_9", "type": "Species", "text": [ "Staphylococcus aureus" ], "offsets": [ [ 277, 298 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1280" } ] }, { "id": "3429373_MESH:D008795_10", "type": "Chemical", "text": [ "metronidazole" ], "offsets": [ [ 337, 350 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008795" } ] }, { "id": "3429373_817_11", "type": "Species", "text": [ "B. fragilis" ], "offsets": [ [ 382, 393 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "817" } ] }, { "id": "3429373_MESH:D015572_12", "type": "Chemical", "text": [ "spiramycin" ], "offsets": [ [ 448, 458 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015572" } ] }, { "id": "3429373_MESH:D008795_13", "type": "Chemical", "text": [ "metronidazole" ], "offsets": [ [ 554, 567 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008795" } ] }, { "id": "3429373_MESH:D015572_14", "type": "Chemical", "text": [ "spiramycin" ], "offsets": [ [ 572, 582 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015572" } ] }, { "id": "3429373_29523_15", "type": "Species", "text": [ "Bacteroides spp" ], "offsets": [ [ 601, 616 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "29523" } ] }, { "id": "3429373_10090_16", "type": "Species", "text": [ "mice" ], "offsets": [ [ 641, 645 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "3429373_29523_17", "type": "Species", "text": [ "Bacteroides spp" ], "offsets": [ [ 675, 690 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "29523" } ] }, { "id": "3429373_1280_18", "type": "Species", "text": [ "S. aureus" ], "offsets": [ [ 721, 730 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1280" } ] }, { "id": "3429373_1280_19", "type": "Species", "text": [ "S. aureus" ], "offsets": [ [ 786, 795 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1280" } ] }, { "id": "3429373_MESH:D007239_20", "type": "Disease", "text": [ "infections" ], "offsets": [ [ 815, 825 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "3429373_817_21", "type": "Species", "text": [ "bacteroides" ], "offsets": [ [ 831, 842 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "817" } ] }, { "id": "3429373_MESH:D008795_22", "type": "Chemical", "text": [ "metronidazole" ], "offsets": [ [ 866, 879 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008795" } ] }, { "id": "3429373_MESH:D008795_23", "type": "Chemical", "text": [ "metronidazole" ], "offsets": [ [ 942, 955 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008795" } ] }, { "id": "3429373_MESH:D015572_24", "type": "Chemical", "text": [ "spiramycin" ], "offsets": [ [ 960, 970 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015572" } ] } ]

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[ { "id": "3640796_title", "type": "title", "text": [ "Continuous infusion of opioid drugs in the treatment of cancer pain: guidelines for use." ], "offsets": [ [ 0, 88 ] ] }, { "id": "3640796_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 89, 89 ] ] } ]

[ { "id": "3640796_MESH:D000072716_0", "type": "Disease", "text": [ "cancer pain" ], "offsets": [ [ 56, 67 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000072716" } ] } ]

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[ { "id": "5203593_title", "type": "title", "text": [ "Why occupational therapy?" ], "offsets": [ [ 0, 25 ] ] }, { "id": "5203593_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 26, 26 ] ] } ]

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[ { "id": "20367864_title", "type": "title", "text": [ "Evidence: philosophy of science meets medicine." ], "offsets": [ [ 0, 47 ] ] }, { "id": "20367864_abstract", "type": "abstract", "text": [ "Obviously medicine should be evidence-based. The issues lie in the details: what exactly counts as evidence? Do certain kinds of evidence carry more weight than others? (And if so why?) And how exactly should medicine be based on evidence? When it comes to these details, the evidence-based medicine (EBM) movement has got itself into a mess - or so it will be argued. In order to start to resolve this mess, we need to go 'back to basics'; and that means turning to the philosophy of science. The theory of evidence, or rather the logic of the interrelations between theory and evidence, has always been central to the philosophy of science - sometimes under the alias of the 'theory of confirmation'. When taken together with a little philosophical common sense, this logic can help us move towards a position on evidence in medicine that is more sophisticated and defensible than anything that EBM has been able so far to supply." ], "offsets": [ [ 48, 980 ] ] } ]

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[ { "id": "733208_title", "type": "title", "text": [ "[Clinico-bacteriological comparisons in the restorative therapy of wounds and trophic ulcers of the stumps]." ], "offsets": [ [ 0, 108 ] ] }, { "id": "733208_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 109, 109 ] ] } ]

[ { "id": "733208_MESH:D014456_0", "type": "Disease", "text": [ "ulcers of the stumps" ], "offsets": [ [ 86, 106 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014456" } ] } ]

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[ { "id": "28792450_title", "type": "title", "text": [ "Determination of Zinc, Cadmium, Lead, Copper and Silver Using a Carbon Paste Electrode and a Screen Printed Electrode Modified with Chromium(III) Oxide." ], "offsets": [ [ 0, 152 ] ] }, { "id": "28792450_abstract", "type": "abstract", "text": [ "In this study, the preparation and electrochemical application of a chromium(III) oxide modified carbon paste electrode (Cr-CPE) and a screen printed electrode (SPE), made from the same material and optimized for the simple, cheap and sensitive simultaneous determination of zinc, cadmium, lead, copper and the detection of silver ions, is described. The limits of detection and quantification were 25 and 80 microg L-1 for Zn(II), 3 and 10 microg L-1 for Cd(II), 3 and 10 microg L-1 for Pb(II), 3 and 10 microg L-1 for Cu(II), and 3 and 10 microg L-1 for Ag(I), respectively. Furthermore, this promising modification was transferred to the screen-printed electrode. The limits of detection for the simultaneous determination of zinc, cadmium, copper and lead on the screen printed electrodes were found to be 350 microg L-1 for Zn(II), 25 microg L-1 for Cd(II), 3 microg L-1 for Pb(II) and 3 microg L-1 for Cu(II). Practical usability for the simultaneous detection of these heavy metal ions by the Cr-CPE was also demonstrated in the analyses of wastewaters." ], "offsets": [ [ 153, 1213 ] ] } ]

[ { "id": "28792450_MESH:D002104_0", "type": "Chemical", "text": [ "Cadmium" ], "offsets": [ [ 23, 30 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002104" } ] }, { "id": "28792450_MESH:D003300_1", "type": "Chemical", "text": [ "Copper" ], "offsets": [ [ 38, 44 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "28792450_MESH:D012834_2", "type": "Chemical", "text": [ "Silver" ], "offsets": [ [ 49, 55 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012834" } ] }, { "id": "28792450_MESH:D002244_3", "type": "Chemical", "text": [ "Carbon" ], "offsets": [ [ 64, 70 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002244" } ] }, { "id": "28792450_MESH:C023600_4", "type": "Chemical", "text": [ "Chromium(III) Oxide" ], "offsets": [ [ 132, 151 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C023600" } ] }, { "id": "28792450_MESH:C023600_5", "type": "Chemical", "text": [ "chromium(III) oxide" ], "offsets": [ [ 221, 240 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C023600" } ] }, { "id": "28792450_MESH:D002244_6", "type": "Chemical", "text": [ "carbon" ], "offsets": [ [ 250, 256 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002244" } ] }, { "id": "28792450_MESH:D002104_7", "type": "Chemical", "text": [ "cadmium" ], "offsets": [ [ 434, 441 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002104" } ] }, { "id": "28792450_MESH:D003300_8", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 449, 455 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "28792450_MESH:D012834_9", "type": "Chemical", "text": [ "silver" ], "offsets": [ [ 477, 483 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012834" } ] }, { "id": "28792450_-_10", "type": "Chemical", "text": [ "Zn(II)" ], "offsets": [ [ 577, 583 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "28792450_-_11", "type": "Chemical", "text": [ "Cd(II)" ], "offsets": [ [ 609, 615 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "28792450_-_12", "type": "Chemical", "text": [ "Pb(II)" ], "offsets": [ [ 641, 647 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "28792450_-_13", "type": "Chemical", "text": [ "Cu(II)" ], "offsets": [ [ 673, 679 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "28792450_MESH:D002104_14", "type": "Chemical", "text": [ "cadmium" ], "offsets": [ [ 888, 895 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002104" } ] }, { "id": "28792450_MESH:D003300_15", "type": "Chemical", "text": [ "copper" ], "offsets": [ [ 897, 903 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003300" } ] }, { "id": "28792450_-_16", "type": "Chemical", "text": [ "Zn(II)" ], "offsets": [ [ 982, 988 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "28792450_-_17", "type": "Chemical", "text": [ "Cd(II)" ], "offsets": [ [ 1008, 1014 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "28792450_-_18", "type": "Chemical", "text": [ "Pb(II)" ], "offsets": [ [ 1033, 1039 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "28792450_-_19", "type": "Chemical", "text": [ "Cu(II)" ], "offsets": [ [ 1061, 1067 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "28792450_MESH:D008670_20", "type": "Chemical", "text": [ "metal" ], "offsets": [ [ 1135, 1140 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008670" } ] }, { "id": "28792450_-_21", "type": "Chemical", "text": [ "Cr-CPE" ], "offsets": [ [ 1153, 1159 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "24980557_title", "type": "title", "text": [ "Surgical outcomes of non-small-cell lung carcinoma in patients previously treated for gastric cancer." ], "offsets": [ [ 0, 101 ] ] }, { "id": "24980557_abstract", "type": "abstract", "text": [ "OBJECTIVES: Although the incidence of non-small-cell lung cancer (NSCLC) as a second malignancy is increasing, the prognosis remains controversial. Therefore, the present study aimed to determine the prognosis of patients with NSCLC who had previously been treated for gastric cancer (PGC). METHODS: The clinicopathological records of patients who underwent complete surgical resection for NSCLC in three institutions from 2000 to 2013 were retrospectively investigated. RESULTS: A total of 4651 patients were eligible for this study: 100 (2.1%) were patients with PGC and 4551 (97.9%) were patients with NSCLC who had not previously been treated for gastric cancer (NGC). The populations of older patients (P < 0.001), males (P < 0.001), limited resection for NSCLC (P = 0.015) and non-adenocarcinoma (P = 0.024) were significantly higher in the PGC, than in the NGC group. Overall survival did not significantly differ between the PGC and NGC groups (76.4 vs 74.5% P = 0.82). Multivariate analysis revealed that more advanced age, male sex, higher serum carcinoembryonic antigen levels, more advanced clinical stage of lung cancer and nonadenocarcinoma were independent factors for a poor prognosis, whereas a history of gastric cancer was not. None of the factors associated with gastric cancer affected the survival of patients with PGC. CONCLUSIONS: After surgical treatment for lung cancer, a history of gastric cancer treatment had low impact on survival and no factors related to gastric cancer influence the outcomes. Curative surgery for NSCLC should be recommended when previously treated gastric cancer is well controlled." ], "offsets": [ [ 102, 1736 ] ] } ]

[ { "id": "24980557_MESH:D008175_0", "type": "Disease", "text": [ "lung carcinoma" ], "offsets": [ [ 36, 50 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008175" } ] }, { "id": "24980557_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 54, 62 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24980557_MESH:D013274_2", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 86, 100 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "24980557_MESH:D002289_3", "type": "Disease", "text": [ "non-small-cell lung cancer" ], "offsets": [ [ 140, 166 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002289" } ] }, { "id": "24980557_MESH:D002289_4", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 168, 173 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002289" } ] }, { "id": "24980557_MESH:D009369_5", "type": "Disease", "text": [ "malignancy" ], "offsets": [ [ 187, 197 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "24980557_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 315, 323 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24980557_MESH:D002289_7", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 329, 334 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002289" } ] }, { "id": "24980557_MESH:D013274_8", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 371, 385 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "24980557_5225_9", "type": "Gene", "text": [ "PGC" ], "offsets": [ [ 387, 390 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5225" } ] }, { "id": "24980557_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 437, 445 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24980557_MESH:D002289_11", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 492, 497 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002289" } ] }, { "id": "24980557_9606_12", "type": "Species", "text": [ "patients" ], "offsets": [ [ 598, 606 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24980557_9606_13", "type": "Species", "text": [ "patients" ], "offsets": [ [ 653, 661 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24980557_5225_14", "type": "Gene", "text": [ "PGC" ], "offsets": [ [ 667, 670 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5225" } ] }, { "id": "24980557_9606_15", "type": "Species", "text": [ "patients" ], "offsets": [ [ 693, 701 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24980557_MESH:D002289_16", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 707, 712 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002289" } ] }, { "id": "24980557_MESH:D013274_17", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 753, 767 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "24980557_9606_18", "type": "Species", "text": [ "patients" ], "offsets": [ [ 800, 808 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24980557_MESH:D002289_19", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 863, 868 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002289" } ] }, { "id": "24980557_MESH:D000230_20", "type": "Disease", "text": [ "non-adenocarcinoma" ], "offsets": [ [ 885, 903 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000230" } ] }, { "id": "24980557_5225_21", "type": "Gene", "text": [ "PGC" ], "offsets": [ [ 949, 952 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5225" } ] }, { "id": "24980557_5225_22", "type": "Gene", "text": [ "PGC" ], "offsets": [ [ 1035, 1038 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5225" } ] }, { "id": "24980557_MESH:D008175_23", "type": "Disease", "text": [ "lung cancer" ], "offsets": [ [ 1223, 1234 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008175" } ] }, { "id": "24980557_MESH:D013274_24", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 1325, 1339 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "24980557_MESH:D013274_25", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 1385, 1399 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "24980557_9606_26", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1425, 1433 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "24980557_5225_27", "type": "Gene", "text": [ "PGC" ], "offsets": [ [ 1439, 1442 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "5225" } ] }, { "id": "24980557_MESH:D008175_28", "type": "Disease", "text": [ "lung cancer" ], "offsets": [ [ 1486, 1497 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008175" } ] }, { "id": "24980557_MESH:D013274_29", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 1512, 1526 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "24980557_MESH:D013274_30", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 1590, 1604 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "24980557_MESH:D002289_31", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 1650, 1655 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002289" } ] }, { "id": "24980557_MESH:D013274_32", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 1702, 1716 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] } ]

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[ { "id": "2612401_title", "type": "title", "text": [ "Waning significance of anti-streptolysin O (ASO) titres in diagnosing streptococcal infections in Lagos, Nigeria." ], "offsets": [ [ 0, 113 ] ] }, { "id": "2612401_abstract", "type": "abstract", "text": [ "A total of 200 serum specimens comprising 100 specimens from patients with streptococcal disease conditions, 50 from patients with other diseases and another 50 specimens from apparently healthy individuals were collected from Lagos University Teaching Hospital and from various areas of Lagos metropolis and screened for the presence of anti-streptolysin O (ASO). For streptococcal disease conditions, other diseases and for apparently healthy persons, anti-streptolysin O titres above 250 iu/ml recorded for each category of clinical conditions in terms of the number examined were 34%, 36% and 28% respectively. It is therefore suggested that high anti-streptolysin O (ASO) titres occur in apparently healthy individuals with no history of streptococcal infection and individuals with disease conditions other than those of streptococcal origin. Consequently the diagnosis of streptococcal diseases based on high titres of ASO in Lagos, is not pathognomonic, should be interpreted with caution and must not be definitive since healthy individuals and others without streptococcal infections develop high ASO titres." ], "offsets": [ [ 114, 1232 ] ] } ]

[ { "id": "2612401_MESH:D013290_0", "type": "Disease", "text": [ "streptococcal infections" ], "offsets": [ [ 70, 94 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013290" } ] }, { "id": "2612401_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 175, 183 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "2612401_MESH:D013290_2", "type": "Disease", "text": [ "streptococcal disease" ], "offsets": [ [ 189, 210 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013290" } ] }, { "id": "2612401_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 231, 239 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "2612401_MESH:D013290_4", "type": "Disease", "text": [ "streptococcal disease" ], "offsets": [ [ 483, 504 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013290" } ] }, { "id": "2612401_MESH:D013290_5", "type": "Disease", "text": [ "streptococcal infection" ], "offsets": [ [ 857, 880 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013290" } ] }, { "id": "2612401_MESH:D013290_6", "type": "Disease", "text": [ "streptococcal diseases" ], "offsets": [ [ 993, 1015 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013290" } ] }, { "id": "2612401_MESH:D013290_7", "type": "Disease", "text": [ "streptococcal infections" ], "offsets": [ [ 1183, 1207 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013290" } ] } ]

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[ { "id": "4692664_title", "type": "title", "text": [ "Standardized diagram for rapid tabulation of coronary arteriograms." ], "offsets": [ [ 0, 67 ] ] }, { "id": "4692664_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 68, 68 ] ] } ]

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[ { "id": "22244_title", "type": "title", "text": [ "Gastric mucosal damage by taurine and glycine conjugates of chenodeoxycholic acid." ], "offsets": [ [ 0, 82 ] ] }, { "id": "22244_abstract", "type": "abstract", "text": [ "Bile damage to gastric mucosa may be demonstrated by means of changes in the transmucosal movement of H+ and Na+ ions. In the present study pure 10 mM solutions of taurine and glycine conjugates of chenodeoxycholic acid were instilled into canine Heidenhain pouches. Solutions were prepared at pH 2, 4, and 8, as previous work had shown a greater damaging effect at low pH. The present study confirmed this pH effect, but only with respect to movement of Na+ ion for taurine conjugates. The magnitude of the changes in ionic movements was much greater with pure bile acid solutions than that seen previously with whole bile. These findings are discussed. The greater damage seen below the pKa of the bile acid conjugates suggests that its nonionized form is the more damaging." ], "offsets": [ [ 83, 859 ] ] } ]

[ { "id": "22244_MESH:D013272_0", "type": "Disease", "text": [ "Gastric mucosal damage" ], "offsets": [ [ 0, 22 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013272" } ] }, { "id": "22244_MESH:D013654_1", "type": "Chemical", "text": [ "taurine" ], "offsets": [ [ 26, 33 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013654" } ] }, { "id": "22244_MESH:D005998_2", "type": "Chemical", "text": [ "glycine" ], "offsets": [ [ 38, 45 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005998" } ] }, { "id": "22244_MESH:D002635_3", "type": "Chemical", "text": [ "chenodeoxycholic acid" ], "offsets": [ [ 60, 81 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002635" } ] }, { "id": "22244_MESH:D013272_4", "type": "Disease", "text": [ "Bile damage to gastric mucosa" ], "offsets": [ [ 83, 112 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013272" } ] }, { "id": "22244_MESH:D013654_5", "type": "Chemical", "text": [ "taurine" ], "offsets": [ [ 247, 254 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013654" } ] }, { "id": "22244_MESH:D005998_6", "type": "Chemical", "text": [ "glycine" ], "offsets": [ [ 259, 266 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005998" } ] }, { "id": "22244_MESH:D002635_7", "type": "Chemical", "text": [ "chenodeoxycholic acid" ], "offsets": [ [ 281, 302 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002635" } ] }, { "id": "22244_9615_8", "type": "Species", "text": [ "canine" ], "offsets": [ [ 323, 329 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] }, { "id": "22244_MESH:D013654_9", "type": "Chemical", "text": [ "taurine" ], "offsets": [ [ 550, 557 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013654" } ] }, { "id": "22244_MESH:D001647_10", "type": "Chemical", "text": [ "bile acid" ], "offsets": [ [ 645, 654 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001647" } ] }, { "id": "22244_MESH:D001647_11", "type": "Chemical", "text": [ "bile acid" ], "offsets": [ [ 783, 792 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001647" } ] } ]

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[ { "id": "34221157_title", "type": "title", "text": [ "MyrliMax and Low Back Pain: A Multicentric, Observational, Post-Marketing Surveillance Study in Indian Patients Suffering from Chronic Low Back Pain of Various Pain Intensity." ], "offsets": [ [ 0, 176 ] ] }, { "id": "34221157_abstract", "type": "abstract", "text": [ "Background: Chronic low back pain (LBP) is the most common musculoskeletal condition affecting a person's quality of life. Over the past decades, a lot of work was done in an attempt to reduce the negative impact of LBP, and help patients recover and maintain a better quality of life. Nevertheless, there is still a lot to be done to fully understand the problem of underlying chronic LBP and a wide gap that exist between basic science and applied rehabilitation research on LBP. Objectives: This was an open label, multicentric, observational, post-marketing surveillance study in a real-world setup designed to evaluate the efficacy and safety of MyrliMax capsules containing standardised Commiphora myrrha gum resin extract in Indian subjects with chronic LBP varying in intensity. Materials and methods:This study included 204 subjects diagnosed with chronic LBP at the outpatient department of 20 centres under the supervision of a medical doctor. All subjects took MyrliMax capsules twice daily for 20 days. Visual Analogue Scale (VAS) pain score, rescue medicine requirement, therapy satisfaction scores and safety parameters were assessed as per the schedule. Outcomes:Treatment with MyrliMax capsules significantly (p<0.01) and progressively reduced the VAS score throughout treatment. A significant pain reduction was observed from the second visit. The mean VAS score was 6.58, 4.66, 2.99 and 1.88 on Day 0, Day 7, Day 14 and Day 20, respectively. A similar trend was also observed in subgroups based on gender and severity score. The need of rescue analgesics/NSAIDs was significantly reduced from the second week, indicating a potential of MyrliMax capsules to increase the pain threshold. All physicians and patients were satisfied with the efficacy of MyrliMax capsules assessed by physician's satisfaction score and patient's satisfaction score. There were no significant serious adverse events due to treatment during the study, which indicated that the treatment with MyrliMax was well tolerated by subjects. Conclusion:MyrliMax capsule is a potentially effective and safe therapy for pain reduction in patients suffering from chronic LBP. MyrliMax capsules can be used to reduce pain in NSAIDs intolerant subjects suffering from chronic LBP." ], "offsets": [ [ 177, 2447 ] ] } ]

[ { "id": "34221157_-_0", "type": "Chemical", "text": [ "MyrliMax" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "34221157_MESH:D017116_1", "type": "Disease", "text": [ "Low Back Pain" ], "offsets": [ [ 14, 27 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D017116" } ] }, { "id": "34221157_9606_2", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 104, 112 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34221157_MESH:D017116_3", "type": "Disease", "text": [ "Chronic Low Back Pain" ], "offsets": [ [ 128, 149 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D017116" } ] }, { "id": "34221157_MESH:D010146_4", "type": "Disease", "text": [ "Pain" ], "offsets": [ [ 161, 165 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "34221157_MESH:D017116_5", "type": "Disease", "text": [ "Chronic low back pain" ], "offsets": [ [ 189, 210 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D017116" } ] }, { "id": "34221157_MESH:D009140_6", "type": "Disease", "text": [ "musculoskeletal" ], "offsets": [ [ 236, 251 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009140" } ] }, { "id": "34221157_9606_7", "type": "Species", "text": [ "patients" ], "offsets": [ [ 407, 415 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34221157_318982_8", "type": "Species", "text": [ "Commiphora myrrha" ], "offsets": [ [ 871, 888 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "318982" } ] }, { "id": "34221157_-_9", "type": "Chemical", "text": [ "gum resin" ], "offsets": [ [ 889, 898 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "34221157_9606_10", "type": "Species", "text": [ "outpatient" ], "offsets": [ [ 1054, 1064 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34221157_-_11", "type": "Chemical", "text": [ "MyrliMax" ], "offsets": [ [ 1151, 1159 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "34221157_MESH:D010146_12", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 1223, 1227 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "34221157_-_13", "type": "Chemical", "text": [ "MyrliMax capsules" ], "offsets": [ [ 1373, 1391 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "34221157_MESH:D010146_14", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 1491, 1495 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "34221157_MESH:D010146_15", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 1870, 1874 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "34221157_9606_16", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1905, 1913 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34221157_-_17", "type": "Chemical", "text": [ "MyrliMax" ], "offsets": [ [ 1950, 1958 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "34221157_9606_18", "type": "Species", "text": [ "patient" ], "offsets": [ [ 2016, 2023 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34221157_-_19", "type": "Chemical", "text": [ "MyrliMax" ], "offsets": [ [ 2170, 2178 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "34221157_-_20", "type": "Chemical", "text": [ "MyrliMax" ], "offsets": [ [ 2223, 2231 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "34221157_MESH:D010146_21", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 2289, 2293 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "34221157_9606_22", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2307, 2315 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34221157_-_23", "type": "Chemical", "text": [ "MyrliMax" ], "offsets": [ [ 2344, 2352 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "34221157_MESH:D010146_24", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 2385, 2389 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] } ]

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[ { "id": "32465115_title", "type": "title", "text": [ "Percutaneous Impella Device for Mechanical Circulatory Support in Children with Cardiogenic Shock: Long Term Outcomes." ], "offsets": [ [ 0, 118 ] ] }, { "id": "32465115_abstract", "type": "abstract", "text": [ "PURPOSE: Use of temporary mechanical circulatory support (MCS) is an alternative to increase systemic blood flow avoiding the possible cardiotoxicity and long-term morbidity of inotropes and vasopressors. It is often the only option to achieve hemodynamic stability. Use of temporary MCS is increasing in frequency in children with evolution of new technologies. Recently, catheter deployed micro-axial percutaneous ventricular assist device (PC-VAD) has been approved for management of cardiogenic shock in adults. We present our experience and long-term outcomes associated with use of this device in a pediatric cardiac intensive care unit at a freestanding children's hospital. METHODS: All patients treated for cardiogenic shock with PC-VAD alone between September 2014 and June 2019 were included in retrospective analysis. The device sizes used included CP device which provides up to 4.0 l/min of flow and 5.0 device which provides 5.0 l/min of flow. Demographic and support data were reviewed and reported using descriptive statistics. RESULTS: A total of 24 PC-VAD devices were implanted in 18 patients: CP (n=17), and 5.0 (n=7). Median patient age was 17 years (IQR 15,20), weight of 61 kg (IQR 54,75), and BSA of 1.72 m2(IQR 1.58,1.96). Median length of CP support was 5 days (IQR 4,7) and 5.0 was 12 days (IQR 11,22). The most common device related complications included site bleeding 9/24 (38%), ventricular arrhythmias 3/24 (17%) and extremity arterial thrombus 1/24 (4%), with no limb ischemia encountered. Acute renal failure requiring CRRT occurred in 5/18 (38%) patients. None of the patients sustained neurologic injury. Median ICU length of stay was 24 days (IQR 15,45) with median hospital length of stay of 35 days (26,80). The survival to ICU discharge was 89% (16/18) and survival to hospital discharge was 89% (16/18). Twelve out of eighteen (67%) patients were alive at one year. CONCLUSION: Temporary MCS for cardiogenic shock with PC-VAD shows favorable short and long-term outcomes in select pediatric patients. This type of circulatory support can be considered for management of older children with acute cardiogenic shock to achieve quicker hemodynamic stability, end-organ recovery and as a temporary bridge to recovery or clinical decision making. The risk profile in our population was low and only minor complications occurred during the treatment." ], "offsets": [ [ 119, 2505 ] ] } ]

[ { "id": "32465115_9606_0", "type": "Species", "text": [ "Children" ], "offsets": [ [ 66, 74 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_MESH:D066126_1", "type": "Disease", "text": [ "cardiotoxicity" ], "offsets": [ [ 254, 268 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D066126" } ] }, { "id": "32465115_9606_2", "type": "Species", "text": [ "children" ], "offsets": [ [ 437, 445 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_MESH:D015324_3", "type": "Disease", "text": [ "PC-VAD" ], "offsets": [ [ 562, 568 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015324" } ] }, { "id": "32465115_MESH:D012770_4", "type": "Disease", "text": [ "cardiogenic shock" ], "offsets": [ [ 606, 623 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012770" } ] }, { "id": "32465115_9606_5", "type": "Species", "text": [ "children" ], "offsets": [ [ 780, 788 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 814, 822 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_MESH:D012770_7", "type": "Disease", "text": [ "cardiogenic shock" ], "offsets": [ [ 835, 852 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012770" } ] }, { "id": "32465115_MESH:D015324_8", "type": "Disease", "text": [ "PC-VAD" ], "offsets": [ [ 858, 864 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015324" } ] }, { "id": "32465115_MESH:D015324_9", "type": "Disease", "text": [ "PC-VAD" ], "offsets": [ [ 1187, 1193 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015324" } ] }, { "id": "32465115_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1223, 1231 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_9606_11", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1266, 1273 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_MESH:D001145_12", "type": "Disease", "text": [ "ventricular arrhythmias" ], "offsets": [ [ 1530, 1553 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001145" } ] }, { "id": "32465115_MESH:D007511_13", "type": "Disease", "text": [ "ischemia" ], "offsets": [ [ 1621, 1629 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007511" } ] }, { "id": "32465115_MESH:D058186_14", "type": "Disease", "text": [ "Acute renal failure" ], "offsets": [ [ 1643, 1662 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D058186" } ] }, { "id": "32465115_9606_15", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1701, 1709 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_9606_16", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1723, 1731 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_MESH:D009422_17", "type": "Disease", "text": [ "neurologic injury" ], "offsets": [ [ 1742, 1759 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009422" } ] }, { "id": "32465115_9606_18", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1994, 2002 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_MESH:D012770_19", "type": "Disease", "text": [ "cardiogenic shock" ], "offsets": [ [ 2057, 2074 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012770" } ] }, { "id": "32465115_-_20", "type": "Chemical", "text": [ "PC-VAD" ], "offsets": [ [ 2080, 2086 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "32465115_9606_21", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2152, 2160 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_9606_22", "type": "Species", "text": [ "children" ], "offsets": [ [ 2237, 2245 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32465115_MESH:D012770_23", "type": "Disease", "text": [ "acute cardiogenic shock" ], "offsets": [ [ 2251, 2274 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012770" } ] } ]

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[ { "id": "34667010_title", "type": "title", "text": [ "Feasibility of a multifaceted implementation intervention to improve attendance at diabetic retinopathy screening in primary care in Ireland: a cluster randomised pilot trial." ], "offsets": [ [ 0, 175 ] ] }, { "id": "34667010_abstract", "type": "abstract", "text": [ "OBJECTIVES: Diabetic retinopathy screening (DRS) uptake is suboptimal in many countries with limited evidence available on interventions to enhance DRS uptake in primary care. We investigated the feasibility and preliminary effects of an intervention to improve uptake of Ireland's national DRS programme, Diabetic RetinaScreen, among patients with type 1 or type 2 diabetes. DESIGN/SETTING: We conducted a cluster randomised pilot trial, embedded process evaluation and cost analysis in general practice, July 2019 to January 2020. PARTICIPANTS: Eight practices participated in the trial. For the process evaluation, surveys were conducted with 25 staff at intervention practices. Interviews were conducted with nine staff at intervention practices, and 10 patients who received the intervention. INTERVENTIONS: The intervention comprised practice reimbursement, an audit of attendance, electronic prompts targeting professionals, General Practice-endorsed patient reminders and a patient information leaflet. Practices were randomly allocated to intervention (n=4) or wait-list control (n=4) (usual care). OUTCOMES: Staff and patient interviews explored their perspectives on the intervention. Patient registration and attendance, including intention to attend, were measured at baseline and 6 months. Microcosting was used to estimate intervention delivery cost. RESULTS: The process evaluation identified that enablers of feasibility included practice culture and capacity to protect time, systems to organise care, and staff skills, and workarounds to improve intervention 'fit'. At 6 months, 22/71 (31%) of baseline non-attenders in intervention practices subsequently attended screening compared with 15/87 (17%) in control practices. The total delivery cost across intervention practices (patients=363) was $2509, averaging $627 per practice and $6.91 per audited patient. Continuation criteria supported proceeding to a definitive trial. CONCLUSIONS: The Improving Diabetes Eye screening Attendance intervention is feasible in primary care; however, consideration should be given to how best to facilitate local tailoring. A definitive trial of clinical and cost-effectiveness is required with preliminary results suggesting a positive effect on uptake. TRIAL REGISTRATION NUMBER: NCT03901898." ], "offsets": [ [ 176, 2478 ] ] } ]

[ { "id": "34667010_MESH:D003920_0", "type": "Disease", "text": [ "diabetic retinopathy" ], "offsets": [ [ 83, 103 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34667010_MESH:D003920_1", "type": "Disease", "text": [ "Diabetic retinopathy" ], "offsets": [ [ 188, 208 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34667010_MESH:D003920_2", "type": "Disease", "text": [ "Diabetic" ], "offsets": [ [ 482, 490 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34667010_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 511, 519 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_MESH:D003924_4", "type": "Disease", "text": [ "type 2 diabetes" ], "offsets": [ [ 535, 550 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003924" } ] }, { "id": "34667010_9606_5", "type": "Species", "text": [ "PARTICIPANTS" ], "offsets": [ [ 709, 721 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 934, 942 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_9606_7", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1134, 1141 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_9606_8", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1158, 1165 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_9606_9", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1304, 1311 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_9606_10", "type": "Species", "text": [ "Patient" ], "offsets": [ [ 1372, 1379 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_9606_11", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1973, 1981 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_9606_12", "type": "Species", "text": [ "patient" ], "offsets": [ [ 2048, 2055 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34667010_MESH:D003920_13", "type": "Disease", "text": [ "Diabetes" ], "offsets": [ [ 2150, 2158 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] } ]

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[ { "id": "25739254_title", "type": "title", "text": [ "[One-stage compound grafting of antibiotic-impregnated calcium sulfate and autogenous cancellous bone for the treatment of chronic calcaneal osteomyelitis]." ], "offsets": [ [ 0, 156 ] ] }, { "id": "25739254_abstract", "type": "abstract", "text": [ "OBJECTIVE: To explore the treatment of chronic calcaneal osteomyelitis with bone defect after debridement and evaluate its clinical outcomes. METHODS: From June 2009 to June 2011, 52 patients with chronic calcaneal osteomyelitis were treated with stage-one compound grafting of antibiotic-impregnated calcium sulfate and autogenous cancellous bone,including 12 females and 40 males with an average age of 43 years old ranging from 18 to 67. According to Cierny-Mader classification, there were 34 cases with stage III and 18 with stage IV. There were 32 cases on right side and 20 on left,with a course of 6 months to 3 years. The area of soft tissue wound ranged from 3.0 cm x l.5 cm to 23.0 cm x l2.0 cm. The clinical effects were evaluated according to infection controlling, calcium sulfate absorption,bone defect repair and heel functional recovery. RESULTS: All patients were followed up for 2 to 3.8 years (averaged 2.8 years). Primary healing was achieved in 52 patients. Two cases of recurrence were found post-operatively, 1 case in 3 months and another in 5 months,which were cured after a second operation. Bone repair healing was gained in 1.5 to 3.5 months (averaged 2.5 months). Complete radiological absorption of calcium sulfate was found in 1.2 to 3 months(averaged 2.2 months). Local exudation after removal of drainage tube had been persisting in 10 patients for 2 to 3 months, which was consistent with the time when cacium sulfate were totally absorbed. Flap had partial necrosis in 4 cases,and the wounds were closed after appropriate treatment finally. The mean Maryland score was 88.15+-7.70. There were excellent results in 32 cases, good in 14, fair in 6. CONCLUSION: A satisfactory short-term clinical results can be gained by one-stage compound grafting of antibiotic-impregnated calcium sulfate and autogenous cancellous bone in chronic calcaneal osteomyelitis, but the long-term results need further follow-up. And much more study is also demanded to reduce the exudation of calcium sulfate." ], "offsets": [ [ 157, 2179 ] ] } ]

[ { "id": "25739254_MESH:D002133_0", "type": "Chemical", "text": [ "calcium sulfate" ], "offsets": [ [ 55, 70 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002133" } ] }, { "id": "25739254_MESH:D010019_1", "type": "Disease", "text": [ "chronic calcaneal osteomyelitis" ], "offsets": [ [ 123, 154 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010019" } ] }, { "id": "25739254_MESH:D010019_2", "type": "Disease", "text": [ "calcaneal osteomyelitis" ], "offsets": [ [ 204, 227 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010019" } ] }, { "id": "25739254_MESH:D001847_3", "type": "Disease", "text": [ "bone defect" ], "offsets": [ [ 233, 244 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001847" } ] }, { "id": "25739254_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 340, 348 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25739254_MESH:D010019_5", "type": "Disease", "text": [ "calcaneal osteomyelitis" ], "offsets": [ [ 362, 385 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010019" } ] }, { "id": "25739254_MESH:D002133_6", "type": "Chemical", "text": [ "calcium sulfate" ], "offsets": [ [ 458, 473 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002133" } ] }, { "id": "25739254_MESH:D007239_7", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 913, 922 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "25739254_MESH:D002133_8", "type": "Chemical", "text": [ "calcium sulfate" ], "offsets": [ [ 936, 951 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002133" } ] }, { "id": "25739254_MESH:D001847_9", "type": "Disease", "text": [ "bone defect" ], "offsets": [ [ 963, 974 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001847" } ] }, { "id": "25739254_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1025, 1033 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25739254_9606_11", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1127, 1135 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25739254_MESH:D002133_12", "type": "Chemical", "text": [ "calcium sulfate" ], "offsets": [ [ 1387, 1402 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002133" } ] }, { "id": "25739254_9606_13", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1527, 1535 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25739254_-_14", "type": "Chemical", "text": [ "cacium sulfate" ], "offsets": [ [ 1595, 1609 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25739254_241_15", "type": "Gene", "text": [ "Flap" ], "offsets": [ [ 1633, 1637 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "241" } ] }, { "id": "25739254_MESH:D009336_16", "type": "Disease", "text": [ "necrosis" ], "offsets": [ [ 1650, 1658 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009336" } ] }, { "id": "25739254_MESH:D002133_17", "type": "Chemical", "text": [ "calcium sulfate" ], "offsets": [ [ 1966, 1981 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002133" } ] }, { "id": "25739254_MESH:D010019_18", "type": "Disease", "text": [ "calcaneal osteomyelitis" ], "offsets": [ [ 2024, 2047 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010019" } ] }, { "id": "25739254_MESH:D002133_19", "type": "Chemical", "text": [ "calcium sulfate" ], "offsets": [ [ 2163, 2178 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002133" } ] } ]

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[ { "id": "31576334_title", "type": "title", "text": [ "Extended follow-up on KEYNOTE-024 suggests significant survival benefit for pembrolizumab in patients with PD-L1 >=50%, but unanswered questions remain." ], "offsets": [ [ 0, 152 ] ] }, { "id": "31576334_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 153, 153 ] ] } ]

[ { "id": "31576334_MESH:C582435_0", "type": "Chemical", "text": [ "pembrolizumab" ], "offsets": [ [ 76, 89 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C582435" } ] }, { "id": "31576334_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 93, 101 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "31576334_29126_2", "type": "Gene", "text": [ "PD-L1" ], "offsets": [ [ 107, 112 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "29126" } ] } ]

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[ { "id": "5317404_title", "type": "title", "text": [ "[Chromosome changes in megaloblastic anemia before and after treatment]." ], "offsets": [ [ 0, 72 ] ] }, { "id": "5317404_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 73, 73 ] ] } ]

[ { "id": "5317404_MESH:D000749_0", "type": "Disease", "text": [ "megaloblastic anemia" ], "offsets": [ [ 23, 43 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000749" } ] } ]

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[ { "id": "25274565_title", "type": "title", "text": [ "Senile scleral plaques imaged with enhanced depth optical coherence tomography." ], "offsets": [ [ 0, 79 ] ] }, { "id": "25274565_abstract", "type": "abstract", "text": [ "PURPOSE: Senile scleral plaques (SSP) are sharply demarcated greyish areas located just anterior to the insertions of the horizontal rectus muscles and thus are frequently encountered during transscleral intravitreal injections. The aim of this study was to characterize SSP using enhanced depth imaging spectral domain anterior segment optical coherence tomography (OCT) in a cohort of patients attending intravitreal injection clinics. METHODS: Prospective cross-sectional study of 380 patients attending the clinic for intravitreal injections at the Department of Ophthalmology at the Bern University Hospital. Thirty-two patients with SSP were identified and the anatomical features were assessed using anterior segment OCT. RESULTS: In our patient cohort, we found a SSP prevalence of 8.2%. Senile scleral plaques were easily identifiable using anterior segment OCT and were found at the insertion sites of the horizontal recti muscles. The mean horizontal diameter was 2.2 mm (+-760 mum SD), the mean vertical diameter was 3.3 mm (+-144 mum SD), and the average surface area was 5.3 mm(2) (+-0.4 mm(2) SD). The mean senile scleral plaque thickness was 0.6 mm (+-149 mum SD). The mean distance from the limbus was 2.24 mm for nasally located SSP and 3.22 mm for temporally located SSP. CONCLUSION: SSP are frequently encountered during intravitreal injections as they are located just anterior to the insertion sites of the horizontal recti muscles. Because the scleral stroma is rarefied and due to calcifications within SSP, these areas should be avoided when performing multiple intravitreal injections as this may result in rupture of the sclera." ], "offsets": [ [ 80, 1735 ] ] } ]

[ { "id": "25274565_9606_0", "type": "Species", "text": [ "patients" ], "offsets": [ [ 467, 475 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25274565_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 568, 576 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25274565_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 705, 713 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25274565_9606_3", "type": "Species", "text": [ "patient" ], "offsets": [ [ 825, 832 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25274565_MESH:D015422_4", "type": "Disease", "text": [ "rupture of the sclera" ], "offsets": [ [ 1713, 1734 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015422" } ] } ]

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[ { "id": "1361642_title", "type": "title", "text": [ "Prevention of breast cancer." ], "offsets": [ [ 0, 28 ] ] }, { "id": "1361642_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 29, 29 ] ] } ]

[ { "id": "1361642_MESH:D001943_0", "type": "Disease", "text": [ "breast cancer" ], "offsets": [ [ 14, 27 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001943" } ] } ]

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[ { "id": "16366142_title", "type": "title", "text": [ "Clinical relevance of antikeratin antibodies in rheumatoid arthritis and symmetric polyarthritis associated with hepatitis C infection." ], "offsets": [ [ 0, 135 ] ] }, { "id": "16366142_abstract", "type": "abstract", "text": [ "Chronic hepatitis C virus (HCV) has been linked to extrahepatic autoimmune phenomena. In addition a variety of autoantibodies were found in patients with HCV. This study was performed to assesss the clinical relevance of antikeratin antibodies in rheumatoid arthritis (RA) and in patients with symmetric polyarthritis associated with hepatitis C infection. Serum antikeratin antibodies were evaluated in 3 different groups of patients; all were rheumatoid factor (RF) seropositive: Group 1: 31 patients with HCV associated symmetric polyarthralgia or arthritis. Group 2: 28 patients with RA (modified ACR criteria for probable RA). Group 3: 16 patients with autoimmune disorders other than RA. Seventeen healthy individuals matched for age and sex served as controls. In our study, 75 patients who were rheumatoid factor positive (measured by ELISA, the cutoff was established to 20 U/mL) were tested for antikeratin antibodies using an indirect immunofluorescence technique with 1:10 serum dilution. Antikeratin antibodies were detected in 18/28 (64%) patients with true RA and only 3/31 (9%) patients with HCV-related arthritis (p < 0.0001). Antikeratin antibodies were observed in 3/16 (18%) patients of group 3 (p < 0.05). Antikeratin antibodies were not found in the sera of the healthy controls." ], "offsets": [ [ 136, 1437 ] ] } ]

[ { "id": "16366142_MESH:D001172_0", "type": "Disease", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 48, 68 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001172" } ] }, { "id": "16366142_MESH:D001168_1", "type": "Disease", "text": [ "polyarthritis" ], "offsets": [ [ 83, 96 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001168" } ] }, { "id": "16366142_MESH:D006526_2", "type": "Disease", "text": [ "hepatitis C infection" ], "offsets": [ [ 113, 134 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006526" } ] }, { "id": "16366142_MESH:D019698_3", "type": "Disease", "text": [ "Chronic hepatitis C virus" ], "offsets": [ [ 136, 161 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D019698" } ] }, { "id": "16366142_11103_4", "type": "Species", "text": [ "HCV" ], "offsets": [ [ 163, 166 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "11103" } ] }, { "id": "16366142_9606_5", "type": "Species", "text": [ "patients" ], "offsets": [ [ 276, 284 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_11103_6", "type": "Species", "text": [ "HCV" ], "offsets": [ [ 290, 293 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "11103" } ] }, { "id": "16366142_MESH:D001172_7", "type": "Disease", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 383, 403 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001172" } ] }, { "id": "16366142_MESH:D001172_8", "type": "Disease", "text": [ "RA" ], "offsets": [ [ 405, 407 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001172" } ] }, { "id": "16366142_9606_9", "type": "Species", "text": [ "patients" ], "offsets": [ [ 416, 424 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_MESH:D001168_10", "type": "Disease", "text": [ "polyarthritis" ], "offsets": [ [ 440, 453 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001168" } ] }, { "id": "16366142_MESH:D006526_11", "type": "Disease", "text": [ "hepatitis C infection" ], "offsets": [ [ 470, 491 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006526" } ] }, { "id": "16366142_9606_12", "type": "Species", "text": [ "patients" ], "offsets": [ [ 562, 570 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_MESH:D011695_13", "type": "Disease", "text": [ "rheumatoid" ], "offsets": [ [ 581, 591 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011695" } ] }, { "id": "16366142_9606_14", "type": "Species", "text": [ "patients" ], "offsets": [ [ 630, 638 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_11103_15", "type": "Species", "text": [ "HCV" ], "offsets": [ [ 644, 647 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "11103" } ] }, { "id": "16366142_MESH:D018771_16", "type": "Disease", "text": [ "polyarthralgia" ], "offsets": [ [ 669, 683 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018771" } ] }, { "id": "16366142_MESH:D001168_17", "type": "Disease", "text": [ "arthritis" ], "offsets": [ [ 687, 696 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001168" } ] }, { "id": "16366142_9606_18", "type": "Species", "text": [ "patients" ], "offsets": [ [ 710, 718 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_MESH:D001172_19", "type": "Disease", "text": [ "RA" ], "offsets": [ [ 724, 726 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001172" } ] }, { "id": "16366142_MESH:D001172_20", "type": "Disease", "text": [ "RA" ], "offsets": [ [ 763, 765 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001172" } ] }, { "id": "16366142_9606_21", "type": "Species", "text": [ "patients" ], "offsets": [ [ 780, 788 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_MESH:D001327_22", "type": "Disease", "text": [ "autoimmune disorders" ], "offsets": [ [ 794, 814 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001327" } ] }, { "id": "16366142_MESH:D001172_23", "type": "Disease", "text": [ "RA" ], "offsets": [ [ 826, 828 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001172" } ] }, { "id": "16366142_9606_24", "type": "Species", "text": [ "patients" ], "offsets": [ [ 921, 929 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_MESH:D011695_25", "type": "Disease", "text": [ "rheumatoid" ], "offsets": [ [ 939, 949 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011695" } ] }, { "id": "16366142_9606_26", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1189, 1197 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_MESH:D001172_27", "type": "Disease", "text": [ "RA" ], "offsets": [ [ 1208, 1210 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001172" } ] }, { "id": "16366142_9606_28", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1230, 1238 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16366142_11103_29", "type": "Species", "text": [ "HCV" ], "offsets": [ [ 1244, 1247 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "11103" } ] }, { "id": "16366142_MESH:D001168_30", "type": "Disease", "text": [ "arthritis" ], "offsets": [ [ 1256, 1265 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001168" } ] }, { "id": "16366142_9606_31", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1331, 1339 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "17145904_title", "type": "title", "text": [ "Participation of French general practitioners in end-of-life decisions for their hospitalised patients." ], "offsets": [ [ 0, 103 ] ] }, { "id": "17145904_abstract", "type": "abstract", "text": [ "BACKGROUND AND OBJECTIVE: Assuming the hypothesis that the general practitioner (GP) can and should be a key player in making end-of-life decisions for hospitalised patients, perceptions of GPs' role assigned to them by hospital doctors in making withdrawal decisions for such patients were surveyed. DESIGN: Questionnaire survey. SETTING: Urban (districts located near Paris) and rural (southern France) areas. PARTICIPANTS: GPs. RESULTS: The response rate was 32.2% (161/500), and it was observed that 70.8% of respondents believed that their participation in withdrawal decisions for their hospitalised patients was essential, whereas 42.1% believed that the hospital doctors were sufficiently skilled to make withdrawal decisions without input from the GPs. Most respondents were found to believe that they had the necessary skills (91.9%) and enough time (87.6%) to participate in withdrawal decisions. The last case of treatment withdrawal in hospital for one of their patients was described by 40% (65/161) of respondents, of whom only 40.0% (26/65) believed that they had participated actively in the decision process. The major factors in the multivariate analysis were the GP's strong belief that his or her participation was essential (p = 0.01), information on admission of the patient given to the GP by the hospital department (p = 0.007), rural practice (p = 0.03), visit to the patient dying in hospital (p = 0.02) and a request by the family to be kept informed about the patient (p = 0.003). CONCLUSION: Strong interest was evinced among GPs regarding end-of-life issues, as well as considerable experience of patients dying at home. As GPs are more closely corrected to patients' families, they may be a good choice for third-party intervention in making end-of-life decisions for hospitalised patients." ], "offsets": [ [ 104, 1926 ] ] } ]

[ { "id": "17145904_9606_0", "type": "Species", "text": [ "patients" ], "offsets": [ [ 94, 102 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 269, 277 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 381, 389 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_3", "type": "Species", "text": [ "PARTICIPANTS" ], "offsets": [ [ 516, 528 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 710, 718 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_5", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1079, 1087 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_6", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1394, 1401 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_7", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1498, 1505 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_8", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1593, 1600 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_9", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1732, 1740 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1793, 1801 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "17145904_9606_11", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1917, 1925 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "34343567_title", "type": "title", "text": [ "Reciprocal allostery arising from a bienzyme assembly controls aromatic amino acid biosynthesis in Prevotella nigrescens." ], "offsets": [ [ 0, 121 ] ] }, { "id": "34343567_abstract", "type": "abstract", "text": [ "Modular protein assembly has been widely reported as a mechanism for constructing allosteric machinery. Recently, a distinctive allosteric system has been identified in a bienzyme assembly comprising a 3-deoxy-d-arabino heptulosonate-7-phosphate synthase (DAH7PS) and chorismate mutase (CM). These enzymes catalyze the first and branch point reactions of aromatic amino acid biosynthesis in the bacterium Prevotella nigrescens (PniDAH7PS), respectively. The interactions between these two distinct catalytic domains support functional interreliance within this bifunctional enzyme. The binding of prephenate, the product of CM-catalyzed reaction, to the CM domain is associated with a striking rearrangement of overall protein conformation that alters the interdomain interactions and allosterically inhibits the DAH7PS activity. Here, we have further investigated the complex allosteric communication demonstrated by this bifunctional enzyme. We observed allosteric activation of CM activity in the presence of all DAH7PS substrates. Using small-angle X-ray scattering (SAXS) experiments, we show that changes in overall protein conformations and dynamics are associated with the presence of different DAH7PS substrates and the allosteric inhibitor prephenate. Furthermore, we have identified an extended interhelix loop located in CM domain, loopC320-F333, as a crucial segment for the interdomain structural and catalytic communications. Our results suggest that the dual-function enzyme PniDAH7PS contains a reciprocal allosteric system between the two enzymatic moieties as a result of this bidirectional interdomain communication. This arrangement allows for a complex feedback and feedforward system for control of pathway flux by connecting the initiation and branch point of aromatic amino acid biosynthesis." ], "offsets": [ [ 122, 1939 ] ] } ]

[ { "id": "34343567_MESH:D024322_0", "type": "Chemical", "text": [ "aromatic amino acid" ], "offsets": [ [ 63, 82 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D024322" } ] }, { "id": "34343567_28133_1", "type": "Species", "text": [ "Prevotella nigrescens" ], "offsets": [ [ 99, 120 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "28133" } ] }, { "id": "34343567_MESH:D024322_2", "type": "Chemical", "text": [ "aromatic amino acid" ], "offsets": [ [ 477, 496 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D024322" } ] }, { "id": "34343567_28133_3", "type": "Species", "text": [ "Prevotella nigrescens" ], "offsets": [ [ 527, 548 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "28133" } ] }, { "id": "34343567_MESH:C005550_4", "type": "Chemical", "text": [ "prephenate" ], "offsets": [ [ 719, 729 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C005550" } ] }, { "id": "34343567_MESH:C005550_5", "type": "Chemical", "text": [ "prephenate" ], "offsets": [ [ 1372, 1382 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C005550" } ] }, { "id": "34343567_MESH:D024322_6", "type": "Chemical", "text": [ "aromatic amino acid" ], "offsets": [ [ 1906, 1925 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D024322" } ] } ]

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[ { "id": "14888860_title", "type": "title", "text": [ "Some thoughts for a school health program." ], "offsets": [ [ 0, 42 ] ] }, { "id": "14888860_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 43, 43 ] ] } ]

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[ { "id": "25192681_title", "type": "title", "text": [ "Rare metastases of well-differentiated thyroid cancers: a systematic review." ], "offsets": [ [ 0, 76 ] ] }, { "id": "25192681_abstract", "type": "abstract", "text": [ "BACKGROUND: A minority of metastatic well-differentiated thyroid cancer (WDTC) patients present with end-organ disease other than in the lung, bone or lymph nodes. These metastases tend to be overlooked because of their low incidence, and this results in delayed diagnosis. The purpose of this study was to perform a systematic review of the clinical and histologic features of unusual WDTC metastases. METHODS: A systematic literature search of bibliographic databases, reference lists of articles, and conference proceedings was performed up to 2013. Studies were included if they reported on adult patients with WDTC and pathology-proven metastases to end-organs other than lung, bone, or lymph nodes. A total of 238 studies were included in a qualitative analysis. Data is expressed as N (%) and median [interquartile range]. RESULTS: A total of 492 patients (median age, 62 years [50-70 years]) were identified in 197 case reports and 42 case series. There were 22 different end-organ metastatic sites documented with either papillary [255 (57 %)], follicular [172 (39 %)], or Hurthle-cell [18 (4 %)] histology. A total of 181 (41 %) patients presented with solitary metastasis and 54 (93 %) with elevated serum thyroglobulin. Positron emission tomography and whole-body radioactive iodine scans revealed hypermetabolic foci in 28 (97 %) and 50 (81 %) cases, respectively. Disease-free interval following the initial diagnosis of the primary thyroid cancer was highly variable, ranging from synchronous presentation [66 (33 %)] to metachronous disease after 516 months [mean 86 months (SD 90)]. CONCLUSIONS: WDTC can manifest with highly variable and unusual clinical features. Rare sites of metastases should be considered in the absence of the more common extra-cervical disease recurrence locations." ], "offsets": [ [ 77, 1884 ] ] } ]

[ { "id": "25192681_MESH:D009362_0", "type": "Disease", "text": [ "metastases of well-differentiated thyroid cancers" ], "offsets": [ [ 5, 54 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009362" } ] }, { "id": "25192681_MESH:D013964_1", "type": "Disease", "text": [ "thyroid cancer" ], "offsets": [ [ 134, 148 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013964" } ] }, { "id": "25192681_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25192681_MESH:D058625_3", "type": "Disease", "text": [ "end-organ disease" ], "offsets": [ [ 178, 195 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D058625" } ] }, { "id": "25192681_MESH:D009362_4", "type": "Disease", "text": [ "metastases" ], "offsets": [ [ 247, 257 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009362" } ] }, { "id": "25192681_MESH:D009362_5", "type": "Disease", "text": [ "metastases" ], "offsets": [ [ 468, 478 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009362" } ] }, { "id": "25192681_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 678, 686 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25192681_MESH:D009362_7", "type": "Disease", "text": [ "metastases" ], "offsets": [ [ 718, 728 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009362" } ] }, { "id": "25192681_9606_8", "type": "Species", "text": [ "patients" ], "offsets": [ [ 931, 939 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25192681_9606_9", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1216, 1224 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25192681_7038_10", "type": "Gene", "text": [ "thyroglobulin" ], "offsets": [ [ 1294, 1307 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "7038" } ] }, { "id": "25192681_-_11", "type": "Chemical", "text": [ "radioactive iodine" ], "offsets": [ [ 1353, 1371 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25192681_MESH:C565498_12", "type": "Disease", "text": [ "hypermetabolic foci" ], "offsets": [ [ 1387, 1406 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C565498" } ] }, { "id": "25192681_MESH:D013964_13", "type": "Disease", "text": [ "thyroid cancer" ], "offsets": [ [ 1524, 1538 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013964" } ] }, { "id": "25192681_MESH:D016609_14", "type": "Disease", "text": [ "metachronous disease" ], "offsets": [ [ 1613, 1633 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016609" } ] }, { "id": "25192681_MESH:D009362_15", "type": "Disease", "text": [ "metastases" ], "offsets": [ [ 1774, 1784 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009362" } ] } ]

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[ { "id": "23922771_title", "type": "title", "text": [ "Reorganization of the intact somatosensory cortex immediately after spinal cord injury." ], "offsets": [ [ 0, 87 ] ] }, { "id": "23922771_abstract", "type": "abstract", "text": [ "Sensory deafferentation produces extensive reorganization of the corresponding deafferented cortex. Little is known, however, about the role of the adjacent intact cortex in this reorganization. Here we show that a complete thoracic transection of the spinal cord immediately increases the responses of the intact forepaw cortex to forepaw stimuli (above the level of the lesion) in anesthetized rats. These increased forepaw responses were independent of the global changes in cortical state induced by the spinal cord transection described in our previous work (Aguilar et al., J Neurosci 2010), as the responses increased both when the cortex was in a silent state (down-state) or in an active state (up-state). The increased responses in the intact forepaw cortex correlated with increased responses in the deafferented hindpaw cortex, suggesting that they could represent different points of view of the same immediate state-independent functional reorganization of the primary somatosensory cortex after spinal cord injury. Collectively, the results of the present study and of our previous study suggest that both state-dependent and state-independent mechanisms can jointly contribute to cortical reorganization immediately after spinal cord injury." ], "offsets": [ [ 88, 1345 ] ] } ]

[ { "id": "23922771_MESH:D013119_0", "type": "Disease", "text": [ "spinal cord injury" ], "offsets": [ [ 68, 86 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013119" } ] }, { "id": "23922771_10116_1", "type": "Species", "text": [ "rats" ], "offsets": [ [ 484, 488 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "23922771_MESH:D013119_2", "type": "Disease", "text": [ "spinal cord injury" ], "offsets": [ [ 1098, 1116 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013119" } ] }, { "id": "23922771_MESH:D013119_3", "type": "Disease", "text": [ "spinal cord injury" ], "offsets": [ [ 1326, 1344 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013119" } ] } ]

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