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[ { "id": "33159196_title", "type": "title", "text": [ "Hydroxychloroquine for Prevention of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: Challenges to Trial Conduct During the Global Pandemic." ], "offsets": [ [ 0, 164 ] ] }, { "id": "33159196_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 165, 165 ] ] } ]

[ { "id": "33159196_MESH:D006886_0", "type": "Chemical", "text": [ "Hydroxychloroquine" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006886" } ] }, { "id": "33159196_2697049_1", "type": "Species", "text": [ "Severe Acute Respiratory Syndrome Coronavirus 2" ], "offsets": [ [ 37, 84 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "2697049" } ] }, { "id": "33159196_2697049_2", "type": "Species", "text": [ "SARS-CoV-2" ], "offsets": [ [ 86, 96 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "2697049" } ] }, { "id": "33159196_MESH:D007239_3", "type": "Disease", "text": [ "Infection" ], "offsets": [ [ 98, 107 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] } ]

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[ { "id": "35194952_title", "type": "title", "text": [ "Multidrug Idebenone/Naproxen Co-loaded Aspasomes for Significant in vivo Anti-inflammatory Activity." ], "offsets": [ [ 0, 100 ] ] }, { "id": "35194952_abstract", "type": "abstract", "text": [ "The use of proper nanocarriers for dermal and transdermal delivery of anti-inflammatory drugs recently gained several attentions in the scientific community because they pass intact and accumulate payloads in the deepest layers of skin tissue. Ascorbyl palmitate-based vesicles (aspasomes) can be considered a promising nanocarrier for dermal and transdermal delivery due to their skin whitening properties and suitable delivery of payloads through the skin. The aim of this study was the synthesis of multidrug Idebenone/naproxen co-loaded aspasomes for the development of an effective anti-inflammatory nanomedicine. Aspasomes had suitable physicochemical properties and were safe in vivo if topically applied on human healthy volunteers. Idebenone/naproxen co-loaded aspasomes demonstrated an increased therapeutic efficacy of payloads compared to the commercially available Naprosyn gel, with a rapid decrease of chemical-induced erythema on human volunteers. These promising results strongly suggested a potential application of Idebenone/naproxen multidrug aspasomes for the development of an effective skin anti-inflammatory therapy." ], "offsets": [ [ 101, 1242 ] ] } ]

[ { "id": "35194952_MESH:C036619_0", "type": "Chemical", "text": [ "Idebenone" ], "offsets": [ [ 10, 19 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C036619" } ] }, { "id": "35194952_MESH:D009288_1", "type": "Chemical", "text": [ "Naproxen" ], "offsets": [ [ 20, 28 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009288" } ] }, { "id": "35194952_MESH:C031226_2", "type": "Chemical", "text": [ "Ascorbyl palmitate" ], "offsets": [ [ 345, 363 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C031226" } ] }, { "id": "35194952_MESH:C036619_3", "type": "Chemical", "text": [ "Idebenone" ], "offsets": [ [ 613, 622 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C036619" } ] }, { "id": "35194952_MESH:D009288_4", "type": "Chemical", "text": [ "naproxen" ], "offsets": [ [ 623, 631 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009288" } ] }, { "id": "35194952_9606_5", "type": "Species", "text": [ "human" ], "offsets": [ [ 816, 821 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35194952_MESH:C036619_6", "type": "Chemical", "text": [ "Idebenone" ], "offsets": [ [ 842, 851 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C036619" } ] }, { "id": "35194952_MESH:D009288_7", "type": "Chemical", "text": [ "naproxen" ], "offsets": [ [ 852, 860 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009288" } ] }, { "id": "35194952_MESH:D009288_8", "type": "Chemical", "text": [ "Naprosyn" ], "offsets": [ [ 979, 987 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009288" } ] }, { "id": "35194952_MESH:D004890_9", "type": "Disease", "text": [ "erythema" ], "offsets": [ [ 1036, 1044 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004890" } ] }, { "id": "35194952_9606_10", "type": "Species", "text": [ "human" ], "offsets": [ [ 1048, 1053 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35194952_MESH:C036619_11", "type": "Chemical", "text": [ "Idebenone" ], "offsets": [ [ 1136, 1145 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C036619" } ] }, { "id": "35194952_MESH:D009288_12", "type": "Chemical", "text": [ "naproxen" ], "offsets": [ [ 1146, 1154 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009288" } ] } ]

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[ { "id": "23584032_title", "type": "title", "text": [ "Required ozone doses for removing pharmaceuticals from wastewater effluents." ], "offsets": [ [ 0, 76 ] ] }, { "id": "23584032_abstract", "type": "abstract", "text": [ "The aim of the this study was to investigate the ozone dosage required to remove active pharmaceutical ingredients (APIs) from biologically treated wastewater of varying quality, originated from different raw wastewater and wastewater treatment processes. Secondary effluents from six Swedish wastewater treatment plants (WWTP) were spiked with 42 APIs (nominal concentration mug/L) and treated with different O3 doses (0.5-12.0 mg/L ozone) in bench-scale experiments. In order to compare the sensitivity of APIs in each matrix, the specific dose of ozone required to achieve reduction by one decade of each investigated API (DDO3) was determined for each effluent by fitting a first order equation to the remaining concentration of API at each applied ozone dose. Ozone dose requirements were found to vary significantly between effluents depending on their matrix characteristics. The specific ozone dose was then normalized to the dissolved organic carbon (DOC) of each effluent. The DDO3/DOC ratios were comparable for each API between the effluents. 15 of the 42 investigated APIs could be classified as easily degradable (DDO3/DOC <= 0.7), while 19 were moderately degradable (0.7 < DDO3/DOC <= 1.4), and 8 were recalcitrant towards O3-treatment (DDO3/DOC >1.4). Furthermore, we predict that a reasonable estimate of the ozone dose required to remove any of the investigated APIs may be attained by multiplying the experimental average DDO3/DOC obtained with the actual DOC of any effluent." ], "offsets": [ [ 77, 1573 ] ] } ]

[ { "id": "23584032_MESH:D010126_0", "type": "Chemical", "text": [ "ozone" ], "offsets": [ [ 9, 14 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010126" } ] }, { "id": "23584032_MESH:D010126_1", "type": "Chemical", "text": [ "ozone" ], "offsets": [ [ 126, 131 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010126" } ] }, { "id": "23584032_MESH:D010126_2", "type": "Chemical", "text": [ "ozone" ], "offsets": [ [ 627, 632 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010126" } ] }, { "id": "23584032_-_3", "type": "Chemical", "text": [ "DDO3" ], "offsets": [ [ 703, 707 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "23584032_-_4", "type": "Chemical", "text": [ "API" ], "offsets": [ [ 810, 813 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "23584032_MESH:D010126_5", "type": "Chemical", "text": [ "ozone" ], "offsets": [ [ 830, 835 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010126" } ] }, { "id": "23584032_MESH:D010126_6", "type": "Chemical", "text": [ "Ozone" ], "offsets": [ [ 842, 847 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010126" } ] }, { "id": "23584032_MESH:D010126_7", "type": "Chemical", "text": [ "ozone" ], "offsets": [ [ 973, 978 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010126" } ] }, { "id": "23584032_MESH:D002244_8", "type": "Chemical", "text": [ "carbon" ], "offsets": [ [ 1029, 1035 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002244" } ] }, { "id": "23584032_-_9", "type": "Chemical", "text": [ "DOC" ], "offsets": [ [ 1037, 1040 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "23584032_-_10", "type": "Chemical", "text": [ "DDO3" ], "offsets": [ [ 1064, 1068 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "23584032_-_11", "type": "Chemical", "text": [ "DOC" ], "offsets": [ [ 1069, 1072 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "23584032_MESH:D010126_12", "type": "Chemical", "text": [ "O3" ], "offsets": [ [ 1316, 1318 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010126" } ] }, { "id": "23584032_MESH:D010126_13", "type": "Chemical", "text": [ "ozone" ], "offsets": [ [ 1404, 1409 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010126" } ] }, { "id": "23584032_-_14", "type": "Chemical", "text": [ "DDO3" ], "offsets": [ [ 1519, 1523 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "5379355_title", "type": "title", "text": [ "[Status of the adrenal cortex and thyroid gland in patients with cervix neoplasms]." ], "offsets": [ [ 0, 83 ] ] }, { "id": "5379355_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 84, 84 ] ] } ]

[ { "id": "5379355_9606_0", "type": "Species", "text": [ "patients" ], "offsets": [ [ 51, 59 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "5379355_MESH:D002583_1", "type": "Disease", "text": [ "cervix neoplasms" ], "offsets": [ [ 65, 81 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002583" } ] } ]

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[ { "id": "7350820_title", "type": "title", "text": [ "A performance comparison: USMG-FMG house staff physicians." ], "offsets": [ [ 0, 58 ] ] }, { "id": "7350820_abstract", "type": "abstract", "text": [ "To determine whether differences exist in the performance of United States Medical Graduate (USMG) and Foreign Medical Graduate (FMG) House Staff physicians, inpatient hospital audits evaluating individual physician performance on patient histories and physical examinations were conducted in 14 Maryland and Pennsylvania non-federal, short-term hospitals. A total of 3,204 medical records were abstracted from eight diagnostic categories for 898 house staff physicians, 556 of which were USMGs and 342 were FMGs. The results from these audits indicate that while there is evidence of a strong hospital/type of physician interaction for many of the diagnoses, there was no significant overall difference in performance of USMG and FMG house staff physicians. The largest and most consistent differences in physician performance were associated with hospital characteristics, not physician characteristics." ], "offsets": [ [ 59, 964 ] ] } ]

[ { "id": "7350820_9606_0", "type": "Species", "text": [ "patient" ], "offsets": [ [ 290, 297 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "7350820_-_1", "type": "Chemical", "text": [ "FMGs" ], "offsets": [ [ 567, 571 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "17834162_title", "type": "title", "text": [ "Satellite troubles curtail spacelab data." ], "offsets": [ [ 0, 41 ] ] }, { "id": "17834162_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 42, 42 ] ] } ]

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[ { "id": "3758946_title", "type": "title", "text": [ "Heterogeneous expression of phenobarbital-inducible cytochrome P-450 genes within the hepatic acinus in the rat." ], "offsets": [ [ 0, 112 ] ] }, { "id": "3758946_abstract", "type": "abstract", "text": [ "Within the hepatic acinus, the functional unit of liver parenchyma, the induction of cytochrome P-450 protein by phenobarbital is manifested primarily in hepatocytes located closer to the hepatic venule, i.e., distal hepatocytes. The objective of this study was to determine the levels of cytochromes P-450b and P-450e mRNAs in populations of hepatocytes originating in the proximal or distal half of the liver acinus in the rat, as an approach to the elucidation of the mechanisms responsible for the heterogeneous zonal expression of cytochrome P-450 protein. The development of a new method to isolate hepatocytes originating from the proximal or distal half of the liver acinus enabled the measurement of total cytochrome P-450 content and of cytochromes P-450b and P-450e mRNAs in these hepatocytes. Levels of cytochromes P-450b and P-450e mRNAs were assessed in proximal and distal hepatocytes by Northern blot hybridization of poly(A+)RNA with a cDNA recognizing sequences of these two cytochromes. The kinetics of induction were defined by measuring these parameters after a single phenobarbital injection. Cytochrome P-450 mRNA levels reached maximum induction at 16 hr, returning to basal values by 48 hr. In contrast, total cytochrome P-450 microsomal protein content reached maximum induction after 33 hr. Hepatocytes of the distal half of the hepatic acinus responded to phenobarbital with higher levels of cytochromes P-450b and P-450e mRNAs than proximal hepatocytes. These results indicated that there is modulation of the expression of the cytochromes P-450b and P-450e genes within the hepatic acinus." ], "offsets": [ [ 113, 1732 ] ] } ]

[ { "id": "3758946_MESH:D010634_0", "type": "Chemical", "text": [ "phenobarbital" ], "offsets": [ [ 28, 41 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010634" } ] }, { "id": "3758946_25251_1", "type": "Gene", "text": [ "cytochrome P-450" ], "offsets": [ [ 52, 68 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "25251" } ] }, { "id": "3758946_MESH:D056486_2", "type": "Disease", "text": [ "hepatic acinus" ], "offsets": [ [ 86, 100 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D056486" } ] }, { "id": "3758946_10116_3", "type": "Species", "text": [ "rat" ], "offsets": [ [ 108, 111 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "3758946_MESH:D056486_4", "type": "Disease", "text": [ "hepatic acinus" ], "offsets": [ [ 124, 138 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D056486" } ] }, { "id": "3758946_25251_5", "type": "Gene", "text": [ "cytochrome P-450" ], "offsets": [ [ 198, 214 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "25251" } ] }, { "id": "3758946_MESH:D010634_6", "type": "Chemical", "text": [ "phenobarbital" ], "offsets": [ [ 226, 239 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010634" } ] }, { "id": "3758946_MESH:D017093_7", "type": "Disease", "text": [ "liver acinus" ], "offsets": [ [ 518, 530 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D017093" } ] }, { "id": "3758946_10116_8", "type": "Species", "text": [ "rat" ], "offsets": [ [ 538, 541 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "3758946_25251_9", "type": "Gene", "text": [ "cytochrome P-450" ], "offsets": [ [ 649, 665 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "25251" } ] }, { "id": "3758946_MESH:D017093_10", "type": "Disease", "text": [ "liver acinus" ], "offsets": [ [ 782, 794 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D017093" } ] }, { "id": "3758946_25251_11", "type": "Gene", "text": [ "cytochrome P-450" ], "offsets": [ [ 828, 844 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "25251" } ] }, { "id": "3758946_24300_12", "type": "Gene", "text": [ "P-450b" ], "offsets": [ [ 872, 878 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24300" } ] }, { "id": "3758946_24300_13", "type": "Gene", "text": [ "P-450b" ], "offsets": [ [ 940, 946 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24300" } ] }, { "id": "3758946_MESH:D010634_14", "type": "Chemical", "text": [ "phenobarbital" ], "offsets": [ [ 1203, 1216 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010634" } ] }, { "id": "3758946_25251_15", "type": "Gene", "text": [ "Cytochrome P-450" ], "offsets": [ [ 1228, 1244 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "25251" } ] }, { "id": "3758946_MESH:D056486_16", "type": "Disease", "text": [ "hepatic acinus" ], "offsets": [ [ 1469, 1483 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D056486" } ] }, { "id": "3758946_MESH:D010634_17", "type": "Chemical", "text": [ "phenobarbital" ], "offsets": [ [ 1497, 1510 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010634" } ] }, { "id": "3758946_24300_18", "type": "Gene", "text": [ "P-450b" ], "offsets": [ [ 1682, 1688 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24300" } ] }, { "id": "3758946_MESH:D056486_19", "type": "Disease", "text": [ "hepatic acinus" ], "offsets": [ [ 1717, 1731 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D056486" } ] } ]

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[ { "id": "15531273_title", "type": "title", "text": [ "Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. 1976." ], "offsets": [ [ 0, 159 ] ] }, { "id": "15531273_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 160, 160 ] ] } ]

[ { "id": "15531273_MESH:C013749_0", "type": "Chemical", "text": [ "ML-236A" ], "offsets": [ [ 77, 84 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C013749" } ] }, { "id": "15531273_MESH:C012258_1", "type": "Chemical", "text": [ "ML-236B" ], "offsets": [ [ 89, 96 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C012258" } ] } ]

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[ { "id": "1532377_title", "type": "title", "text": [ "Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice." ], "offsets": [ [ 0, 158 ] ] }, { "id": "1532377_abstract", "type": "abstract", "text": [ "We have analysed the production of a wide variety of cytokines by in vitro concanavalin A (Con A) stimulated mesenteric lymph node cells (MLNC) from strains of mice experiencing chronic (B10.BR, AKR) versus acute (BALB/K) infection with the nematode parasite Trichuris muris. MLNC from infected BALB/K mice produced elevated levels of the Th2-specific cytokines interleukin-5 (IL-5) and IL-9. IL-3 and IL-4 remained at or just above normal. Interferon-gamma (IFN-gamma) (a Th1-type cytokine) was secreted only in small amounts. MLNC from infected susceptible B10.BR and AKR mice produced large amounts of IFN-gamma in the relative absence of IL-4 and IL-9. IL-5 levels failed to rise significantly above normal in B10.BR mice whilst in AKR mice high levels of IL-5 were detected early post-infection (p.i.) but levels decreased dramatically as the infection proceeded to reach normal levels by Day 34. IL-3 levels were depressed below normal. Our results are consistent with the polarization of the Th-cell response during T. muris infection to give predominantly IFN-gamma-secreting Th1 cells in strains of mice unable to expel the parasite and mainly IL-4, IL-5 and IL-9 producing Th2-type cells in resistant strains." ], "offsets": [ [ 159, 1378 ] ] } ]

[ { "id": "1532377_10090_0", "type": "Species", "text": [ "murine" ], "offsets": [ [ 33, 39 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "1532377_70415_1", "type": "Species", "text": [ "Trichuris muris" ], "offsets": [ [ 58, 73 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "70415" } ] }, { "id": "1532377_CVCL_7026;NCBITaxID:9606_2", "type": "CellLine", "text": [ "TH" ], "offsets": [ [ 105, 107 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_7026;NCBITaxID:9606" } ] }, { "id": "1532377_10090_3", "type": "Species", "text": [ "mice" ], "offsets": [ [ 153, 157 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "1532377_10090_4", "type": "Species", "text": [ "mice" ], "offsets": [ [ 319, 323 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "1532377_MESH:D007239_5", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 381, 390 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "1532377_70415_6", "type": "Species", "text": [ "Trichuris muris" ], "offsets": [ [ 418, 433 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "70415" } ] }, { "id": "1532377_MESH:D007239_7", "type": "Disease", "text": [ "infected" ], "offsets": [ [ 445, 453 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "1532377_10090_8", "type": "Species", "text": [ "mice" ], "offsets": [ [ 461, 465 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "1532377_16191_9", "type": "Gene", "text": [ "interleukin-5" ], "offsets": [ [ 521, 534 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16191" } ] }, { "id": "1532377_16191_10", "type": "Gene", "text": [ "IL-5" ], "offsets": [ [ 536, 540 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16191" } ] }, { "id": "1532377_16198_11", "type": "Gene", "text": [ "IL-9" ], "offsets": [ [ 546, 550 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16198" } ] }, { "id": "1532377_16187_12", "type": "Gene", "text": [ "IL-3" ], "offsets": [ [ 552, 556 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16187" } ] }, { "id": "1532377_16189_13", "type": "Gene", "text": [ "IL-4" ], "offsets": [ [ 561, 565 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16189" } ] }, { "id": "1532377_15978_14", "type": "Gene", "text": [ "Interferon-gamma" ], "offsets": [ [ 600, 616 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "15978" } ] }, { "id": "1532377_15978_15", "type": "Gene", "text": [ "IFN-gamma" ], "offsets": [ [ 618, 627 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "15978" } ] }, { "id": "1532377_CVCL_5J51;NCBITaxID:9606_16", "type": "CellLine", "text": [ "Th1" ], "offsets": [ [ 632, 635 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_5J51;NCBITaxID:9606" } ] }, { "id": "1532377_MESH:D007239_17", "type": "Disease", "text": [ "infected" ], "offsets": [ [ 697, 705 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "1532377_10090_18", "type": "Species", "text": [ "mice" ], "offsets": [ [ 733, 737 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "1532377_15978_19", "type": "Gene", "text": [ "IFN-gamma" ], "offsets": [ [ 764, 773 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "15978" } ] }, { "id": "1532377_16189_20", "type": "Gene", "text": [ "IL-4" ], "offsets": [ [ 801, 805 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16189" } ] }, { "id": "1532377_16198_21", "type": "Gene", "text": [ "IL-9" ], "offsets": [ [ 810, 814 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16198" } ] }, { "id": "1532377_16191_22", "type": "Gene", "text": [ "IL-5" ], "offsets": [ [ 816, 820 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16191" } ] }, { "id": "1532377_10090_23", "type": "Species", "text": [ "mice" ], "offsets": [ [ 880, 884 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "1532377_10090_24", "type": "Species", "text": [ "mice" ], "offsets": [ [ 899, 903 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "1532377_16191_25", "type": "Gene", "text": [ "IL-5" ], "offsets": [ [ 919, 923 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16191" } ] }, { "id": "1532377_MESH:D007239_26", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 949, 958 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "1532377_MESH:D007239_27", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 1007, 1016 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "1532377_16187_28", "type": "Gene", "text": [ "IL-3" ], "offsets": [ [ 1061, 1065 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16187" } ] }, { "id": "1532377_CVCL_7026;NCBITaxID:9606_29", "type": "CellLine", "text": [ "Th" ], "offsets": [ [ 1158, 1160 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_7026;NCBITaxID:9606" } ] }, { "id": "1532377_70415_30", "type": "Species", "text": [ "T. muris" ], "offsets": [ [ 1182, 1190 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "70415" } ] }, { "id": "1532377_MESH:D007239_31", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 1191, 1200 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "1532377_15978_32", "type": "Gene", "text": [ "IFN-gamma" ], "offsets": [ [ 1223, 1232 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "15978" } ] }, { "id": "1532377_CVCL_5J51;NCBITaxID:9606_33", "type": "CellLine", "text": [ "Th1" ], "offsets": [ [ 1243, 1246 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_5J51;NCBITaxID:9606" } ] }, { "id": "1532377_10090_34", "type": "Species", "text": [ "mice" ], "offsets": [ [ 1267, 1271 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "1532377_16189_35", "type": "Gene", "text": [ "IL-4" ], "offsets": [ [ 1312, 1316 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16189" } ] }, { "id": "1532377_16191_36", "type": "Gene", "text": [ "IL-5" ], "offsets": [ [ 1318, 1322 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16191" } ] }, { "id": "1532377_16198_37", "type": "Gene", "text": [ "IL-9" ], "offsets": [ [ 1327, 1331 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "16198" } ] } ]

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[ { "id": "16235497_title", "type": "title", "text": [ "Enoxaparin, retroperitoneal haematoma in the elderly and impaired renal function." ], "offsets": [ [ 0, 81 ] ] }, { "id": "16235497_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 82, 82 ] ] } ]

[ { "id": "16235497_MESH:D017984_0", "type": "Chemical", "text": [ "Enoxaparin" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D017984" } ] }, { "id": "16235497_MESH:D012186_1", "type": "Disease", "text": [ "retroperitoneal haematoma" ], "offsets": [ [ 12, 37 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012186" } ] }, { "id": "16235497_MESH:D007674_2", "type": "Disease", "text": [ "impaired renal function" ], "offsets": [ [ 57, 80 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007674" } ] } ]

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[ { "id": "23506769_title", "type": "title", "text": [ "A closer look at the BREAST-Q( )." ], "offsets": [ [ 0, 33 ] ] }, { "id": "23506769_abstract", "type": "abstract", "text": [ "The BREAST-Q( ) is a multiscale, multimodule, patient-reported outcome instrument (PRO) measuring health-related quality of life and patient satisfaction in women who undergo breast surgery. This PRO instrument is the flagship of our team's research, which has spanned almost a decade. This article provides detail about the BREAST-Q( ). The BREAST-Q( ) represents a significant advance in measuring the impact and effectiveness of breast surgery from the patients' perspective. In addition, our overall approach may provide a useful template for the development of future PRO instruments." ], "offsets": [ [ 34, 623 ] ] } ]

[ { "id": "23506769_9606_0", "type": "Species", "text": [ "patient" ], "offsets": [ [ 80, 87 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "23506769_9606_1", "type": "Species", "text": [ "patient" ], "offsets": [ [ 167, 174 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "23506769_9606_2", "type": "Species", "text": [ "women" ], "offsets": [ [ 191, 196 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "23506769_-_3", "type": "Chemical", "text": [ "BREAST-Q" ], "offsets": [ [ 376, 384 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "23506769_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 490, 498 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "21596343_title", "type": "title", "text": [ "Introduction: Clinical pathology and hematology." ], "offsets": [ [ 0, 48 ] ] }, { "id": "21596343_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 49, 49 ] ] } ]

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[ { "id": "6830795_title", "type": "title", "text": [ "The state of association of band 3 protein of the human erythrocyte membrane in solutions of nonionic detergents." ], "offsets": [ [ 0, 113 ] ] }, { "id": "6830795_abstract", "type": "abstract", "text": [ "Band 3 protein, the anion transport protein of the human erythrocyte membrane, was solubilized and purified in aqueous solutions of two nonionic detergents: Ammonyx-LO (dimethyl laurylamine oxide) and C12E9 (nonaethylene glycol lauryl ether). The state of association of the purified protein was studied by analytical ultracentrifugation. Band 3 protein solubilized and studied in solutions of Ammonyx-LO was found to be in a monomer/dimer/tetramer association equilibrium. Band 3 protein freshly prepared in C12 E9 showed the same behaviour; however, during aging the protein was converted into stable noncovalent dimers. The conversion was retarded by the presence of beta-mercaptoethanol or by treatment of the samples with iodoacetamide; it seems to be due to oxidation of the protein by degradation products of the detergent. It is concluded that a monomer/dimer/tetramer association equilibrium is the native state of association of band 3 protein solubilized by nonionic detergents. Since nonionic detergents are assumed not to interfere with protein-protein interactions among membrane proteins, the results strongly support the claim that, in the erythrocyte membrane, band 3 is in a monomer/dimer/tetramer association equilibrium (Dorst, H.-J. and Schubert, D. (1979) Hoppe-Seyler's Z. Physiol. Chem. 360, 1605-1618)." ], "offsets": [ [ 114, 1441 ] ] } ]

[ { "id": "6830795_9606_0", "type": "Species", "text": [ "human" ], "offsets": [ [ 50, 55 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "6830795_9606_1", "type": "Species", "text": [ "human" ], "offsets": [ [ 165, 170 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "6830795_MESH:C014518_2", "type": "Chemical", "text": [ "Ammonyx-LO" ], "offsets": [ [ 271, 281 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C014518" } ] }, { "id": "6830795_-_3", "type": "Chemical", "text": [ "dimethyl laurylamine oxide" ], "offsets": [ [ 283, 309 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "6830795_MESH:C061442_4", "type": "Chemical", "text": [ "C12E9" ], "offsets": [ [ 315, 320 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C061442" } ] }, { "id": "6830795_-_5", "type": "Chemical", "text": [ "nonaethylene glycol lauryl ether" ], "offsets": [ [ 322, 354 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "6830795_-_6", "type": "Chemical", "text": [ "beta-mercaptoethanol" ], "offsets": [ [ 784, 804 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "6830795_MESH:D007460_7", "type": "Chemical", "text": [ "iodoacetamide" ], "offsets": [ [ 841, 854 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007460" } ] } ]

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[ { "id": "1992374_title", "type": "title", "text": [ "Comparison of functional and structural brain disturbances in Wilson's disease." ], "offsets": [ [ 0, 79 ] ] }, { "id": "1992374_abstract", "type": "abstract", "text": [ "We assessed the functional and structural brain disturbances in Wilson's disease (WD) by evoked potentials (EPs) and magnetic resonance imaging (MRI). All the 25 neurologically symptomatic and 44% of the 16 asymptomatic patients, assessed by both EPs (n = 48) and imaging (n = 41), had at least 1 abnormality of either prolonged EP conduction times, imaging-outlined presence of cerebral lesions, or brain atrophy. Our findings indicate that EPs and MRI are sensitive techniques for the evaluation of brain involvement in WD." ], "offsets": [ [ 80, 605 ] ] } ]

[ { "id": "1992374_MESH:D001927_0", "type": "Disease", "text": [ "brain disturbances" ], "offsets": [ [ 40, 58 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001927" } ] }, { "id": "1992374_MESH:D006527_1", "type": "Disease", "text": [ "Wilson's disease" ], "offsets": [ [ 62, 78 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006527" } ] }, { "id": "1992374_MESH:D001927_2", "type": "Disease", "text": [ "brain disturbances" ], "offsets": [ [ 122, 140 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001927" } ] }, { "id": "1992374_MESH:D006527_3", "type": "Disease", "text": [ "Wilson's disease" ], "offsets": [ [ 144, 160 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006527" } ] }, { "id": "1992374_MESH:D006527_4", "type": "Disease", "text": [ "WD" ], "offsets": [ [ 162, 164 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006527" } ] }, { "id": "1992374_9606_5", "type": "Species", "text": [ "patients" ], "offsets": [ [ 300, 308 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "1992374_MESH:D002543_6", "type": "Disease", "text": [ "cerebral lesions" ], "offsets": [ [ 459, 475 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002543" } ] }, { "id": "1992374_MESH:C566985_7", "type": "Disease", "text": [ "brain atrophy" ], "offsets": [ [ 480, 493 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C566985" } ] }, { "id": "1992374_MESH:D006527_8", "type": "Disease", "text": [ "WD" ], "offsets": [ [ 602, 604 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006527" } ] } ]

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[ { "id": "30177633_title", "type": "title", "text": [ "Hierarchical Self-Assembled Structures from Diblock Copolymer Mixtures by Competitive Hydrogen Bonding Strength." ], "offsets": [ [ 0, 112 ] ] }, { "id": "30177633_abstract", "type": "abstract", "text": [ "In this work we prepared poly(styrene-b-vinylphenol) (PS-b-PVPh) by sequential anionic living polymerization and poly(ethylene oxide-b-4-vinylpyridine) (PEO-b-P4VP) by reversible addition fragmentation chain transfer polymerization (RAFT) by using poly(ethylene oxide) 4-cyano-4-(phenylcarbonothioylthio)pentanoate (PEO-SC(S)Ph) as a macroinitiator with two hydrogen bonded acceptor groups. When blending with disordered PEO-b-P4VP diblock copolymer, we found the order-order self-assembled structure transition from lamellar structure for pure PS-b-PVPh to cylindrical, worm-like, and finally to PEO crystalline lamellar structures. Taking the advantage of the DeltaK effect from competitive hydrogen bonding strengths between PVPh/P4VP and PVPh/PEO domains, it could form the hierarchical self-assembled morphologies such as core-shell cylindrical nanostructure." ], "offsets": [ [ 113, 977 ] ] } ]

[ { "id": "30177633_-_0", "type": "Chemical", "text": [ "Diblock Copolymer" ], "offsets": [ [ 44, 61 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "30177633_MESH:D006859_1", "type": "Chemical", "text": [ "Hydrogen" ], "offsets": [ [ 86, 94 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006859" } ] }, { "id": "30177633_MESH:D000755_2", "type": "Disease", "text": [ "PEO-SC(S)Ph" ], "offsets": [ [ 429, 440 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000755" } ] }, { "id": "30177633_-_3", "type": "Chemical", "text": [ "PEO-b-P4VP diblock copolymer" ], "offsets": [ [ 534, 562 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "30177633_-_4", "type": "Chemical", "text": [ "PS-b-PVPh" ], "offsets": [ [ 658, 667 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "30177633_MESH:D006859_5", "type": "Chemical", "text": [ "hydrogen" ], "offsets": [ [ 806, 814 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006859" } ] } ]

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[ { "id": "10263753_title", "type": "title", "text": [ "Residential homes: private lives." ], "offsets": [ [ 0, 33 ] ] }, { "id": "10263753_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 34, 34 ] ] } ]

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[ { "id": "3895885_title", "type": "title", "text": [ "Cinnabar-gold as the best alchemical drug of longevity, called Makaradhwaja in India." ], "offsets": [ [ 0, 85 ] ] }, { "id": "3895885_abstract", "type": "abstract", "text": [ "A drug of longevity, prior to alchemy, was peach, from which the god of longevity has emerged. Alchemy began by synthesizing red colloidal gold with gold to make the body ever-lasting and redness, as soul, to make life eternal. Its climax was reached with cinnabar-gold, which is blood-red, while red-gold is only brick-red. It was called Makaradhwaja in India. There have been fertility gods. Hermes was one and Alchemy has been named a hermetic art. Makara was crocodile-cum-fish, god of fertility. Makaradhwaja means Emblem of god of fertility, signifying a drug conferring vigour of youth." ], "offsets": [ [ 86, 679 ] ] } ]

[ { "id": "3895885_-_0", "type": "Chemical", "text": [ "Cinnabar-gold" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "3895885_3760_1", "type": "Species", "text": [ "peach" ], "offsets": [ [ 129, 134 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "3760" } ] }, { "id": "3895885_MESH:D003117_2", "type": "Disease", "text": [ "redness" ], "offsets": [ [ 274, 281 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003117" } ] } ]

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[ { "id": "16568527_title", "type": "title", "text": [ "Simultaneous dislocations of the carpometacarpal joints: a case report." ], "offsets": [ [ 0, 71 ] ] }, { "id": "16568527_abstract", "type": "abstract", "text": [ "A case of simultaneous dislocations of the carpometacarpal joints is reported. Closed reduction and splinting produced a good result." ], "offsets": [ [ 72, 205 ] ] } ]

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[ { "id": "14108703_title", "type": "title", "text": [ "[EXANTHEMAS DUE TO GRISEOFULVIN THERAPY]." ], "offsets": [ [ 0, 41 ] ] }, { "id": "14108703_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 42, 42 ] ] } ]

[ { "id": "14108703_MESH:D006118_0", "type": "Chemical", "text": [ "GRISEOFULVIN" ], "offsets": [ [ 19, 31 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006118" } ] } ]

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[ { "id": "33456734_title", "type": "title", "text": [ "Trend in Prevalence of Hepatitis B Virus Infection Among Blood Donor Individuals: An Eleven-year of Experience in Lorestan, Iran." ], "offsets": [ [ 0, 129 ] ] }, { "id": "33456734_abstract", "type": "abstract", "text": [ "Background: Hepatitis B virus is one of the transfusion transmissible infections. Despite the availability of hepatitis B virus (HBV) vaccine and screening tests but still danger of virus transmission via blood transfusion is high in some regions. The objective of this study was to determine the trend of seroprevalence of hepatitis B in over an 11-year period (2005-2015). Methods: In this study, 355,083 blood donors were estimated for hepatitis B surface antigen (HBs Ag) seropositivity during 2005-2015 who referred to blood infusion centers of Lorestan province. Third-generation ELISA method was used to detect HBs Ag. Results: The prevalence of HBs Ag in blood donors was 0.29% (1017). It was decreased steadily from 2005 to 2015 (0.68% to 0.12%) but increased in 2008 year. The trend prevalence of HBs Ag seropositivity significantly decreased over the study period (P < 0.001). The decline in HBV infection rates was more prominent in regular and repeated donor's groups compared to people who donated blood for the first time (P < 0.001). Conclusions: The result of present study was indicated, Lorestan city in west of Iran can be classified as a low-income region because the low prevalence of HBs Ag in blood donors. Also the prevalence of HBs Ag in first-time donors was higher than other groups." ], "offsets": [ [ 130, 1441 ] ] } ]

[ { "id": "33456734_MESH:D006509_0", "type": "Disease", "text": [ "Hepatitis B Virus Infection" ], "offsets": [ [ 23, 50 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006509" } ] }, { "id": "33456734_10407_1", "type": "Species", "text": [ "Hepatitis B virus" ], "offsets": [ [ 142, 159 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10407" } ] }, { "id": "33456734_MESH:D007239_2", "type": "Disease", "text": [ "infections" ], "offsets": [ [ 200, 210 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "33456734_10407_3", "type": "Species", "text": [ "hepatitis B virus" ], "offsets": [ [ 240, 257 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10407" } ] }, { "id": "33456734_10407_4", "type": "Species", "text": [ "HBV" ], "offsets": [ [ 259, 262 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10407" } ] }, { "id": "33456734_MESH:D006509_5", "type": "Disease", "text": [ "hepatitis B" ], "offsets": [ [ 454, 465 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006509" } ] }, { "id": "33456734_MESH:D006509_6", "type": "Disease", "text": [ "hepatitis B" ], "offsets": [ [ 569, 580 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006509" } ] }, { "id": "33456734_10407_7", "type": "Species", "text": [ "HBV" ], "offsets": [ [ 1033, 1036 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10407" } ] }, { "id": "33456734_9606_8", "type": "Species", "text": [ "people" ], "offsets": [ [ 1123, 1129 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "32880417_title", "type": "title", "text": [ "Infanticide and Infanticide Statutes in Australia and New Zealand." ], "offsets": [ [ 0, 66 ] ] }, { "id": "32880417_abstract", "type": "abstract", "text": [ "A major postpartum depression may develop insidiously and go untreated and represent a potentially serious hazard to the wellbeing of both the mother and her child or children. Infanticide is the term used to describe the deliberate act of a parent killing their own young child. The original Infanticide Act 1922 of England and Wales applied to a woman who caused the death of her \"newly born\" child at the time when she had not fully recovered from the effect of giving birth to such child and by reason thereof \"the balance of her mind was disturbed\". The subsequent Infanticide Act 1938 (1 & 2 Geo 6, c 36) provided that the victim child could be any age up to 12 months. After reviewing the phenomenology of postpartum depression, maternal child murder (infanticide and filicide) and post-traumatic stress disorder, this article examines the recommendations of various law reform commissions and the development of infanticide statutes in Australia and New Zealand. The article compares and contrasts the different provisions and concludes with some recommendations for law reform." ], "offsets": [ [ 67, 1153 ] ] } ]

[ { "id": "32880417_MESH:D000275_0", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 86, 96 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "32880417_9606_1", "type": "Species", "text": [ "child" ], "offsets": [ [ 225, 230 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32880417_9606_2", "type": "Species", "text": [ "children" ], "offsets": [ [ 234, 242 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32880417_9606_3", "type": "Species", "text": [ "child" ], "offsets": [ [ 340, 345 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32880417_9606_4", "type": "Species", "text": [ "woman" ], "offsets": [ [ 415, 420 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32880417_9606_5", "type": "Species", "text": [ "child" ], "offsets": [ [ 462, 467 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32880417_9606_6", "type": "Species", "text": [ "child" ], "offsets": [ [ 553, 558 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32880417_9606_7", "type": "Species", "text": [ "child" ], "offsets": [ [ 703, 708 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32880417_MESH:D000275_8", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 791, 801 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "32880417_9606_9", "type": "Species", "text": [ "child" ], "offsets": [ [ 812, 817 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32880417_MESH:D040921_10", "type": "Disease", "text": [ "traumatic stress disorder" ], "offsets": [ [ 861, 886 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D040921" } ] } ]

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[ { "id": "8950881_title", "type": "title", "text": [ "Randomised trial of MNrgp120 HIV-1 vaccine in symptomless HIV-1 infection." ], "offsets": [ [ 0, 74 ] ] }, { "id": "8950881_abstract", "type": "abstract", "text": [ "BACKGROUND: Most individuals infected with HIV-1 show disease progression despite both cellular and humoral immune responses. We investigated whether immunisation of patients who had symptomless HIV-1 infection with an envelope subcomponent vaccine (MNrgp120) to augment immune response can slow progression of HIV-1 disease. METHODS: In a randomised, double-blind, placebo-controlled trial, carried out in university infectious disease clinics and community infectious disease practices, we enrolled 573 HIV-infected patients with CD4 counts above 600 cells/microL (0.6 x 10(9)/L). Patients received 600 micrograms vaccine or placebo by intramuscular injection monthly for 6 months then every alternate month throughout the study. The primary endpoint was the rate of decline in CD4 count; secondary endpoints were HIV-1 RNA concentrations in plasma and minor clinical events associated with HIV. Analysis was by intention to treat. FINDINGS: At baseline, the study participants had a mean CD4 count of 775 cells/microL (SD 172) and 89% of participants had detectable HIV RNA (> 200 copies/mL). These RNA-positive individuals had a median viral load of 9250 copies/mL (IQR 2670-26960). Analysis after 15 months of follow-up of the 568 subjects who had at least one CD4 count done after randomisation showed no difference between the 287 vaccine recipients and 281 placebo recipients in rate of decline of CD4 count (yearly decrease 53.8 [SE 7.6] vs 42.3 [7.6] cells/microL; ratio of mean gradients 1.27 [95% CI 0.63-2.55]) or in plasma HIV-1 RNA concentrations (p > or = 0.63). The study was designed with power to detect a vaccine-induced reduction in rate of decline in CD4 count of 60%; these results exclude with 95% confidence a reduction of 40% or more. More vaccine-treated patients than placebo recipients showed a 50% decrease in CD4 count (11 vs 5; relative risk 2.15 [95% CI 0.76-6.12], p = 0.13). The frequencies of HIV-related minor clinical events were similar in the two groups. Pain at the injection site was the only adverse event that occurred more frequently in vaccine-treated group. INTERPRETATION: Postinfection immunisation of symptom-free HIV-infected patients with MNrgp120 vaccine did not alter HIV-1 disease progression as measured by immunological, virological, and clinical endpoints over a 15-month period." ], "offsets": [ [ 75, 2412 ] ] } ]

[ { "id": "8950881_11676_0", "type": "Species", "text": [ "HIV-1" ], "offsets": [ [ 29, 34 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "11676" } ] }, { "id": "8950881_MESH:D015658_1", "type": "Disease", "text": [ "HIV-1 infection" ], "offsets": [ [ 58, 73 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015658" } ] }, { "id": "8950881_MESH:D007239_2", "type": "Disease", "text": [ "infected" ], "offsets": [ [ 104, 112 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "8950881_MESH:D005254_3", "type": "Disease", "text": [ "HIV-1 show disease" ], "offsets": [ [ 118, 136 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005254" } ] }, { "id": "8950881_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 241, 249 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "8950881_MESH:D015658_5", "type": "Disease", "text": [ "HIV-1 infection" ], "offsets": [ [ 270, 285 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015658" } ] }, { "id": "8950881_MESH:D015658_6", "type": "Disease", "text": [ "HIV-1 disease" ], "offsets": [ [ 386, 399 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015658" } ] }, { "id": "8950881_MESH:D003141_7", "type": "Disease", "text": [ "infectious disease" ], "offsets": [ [ 493, 511 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003141" } ] }, { "id": "8950881_MESH:D003141_8", "type": "Disease", "text": [ "infectious disease" ], "offsets": [ [ 534, 552 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003141" } ] }, { "id": "8950881_MESH:D015658_9", "type": "Disease", "text": [ "HIV-infected" ], "offsets": [ [ 580, 592 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015658" } ] }, { "id": "8950881_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 593, 601 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "8950881_920_11", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 607, 610 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "8950881_9606_12", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 658, 666 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "8950881_920_13", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 855, 858 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "8950881_11676_14", "type": "Species", "text": [ "HIV-1" ], "offsets": [ [ 891, 896 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "11676" } ] }, { "id": "8950881_9606_15", "type": "Species", "text": [ "participants" ], "offsets": [ [ 1042, 1054 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "8950881_920_16", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 1066, 1069 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "8950881_9606_17", "type": "Species", "text": [ "participants" ], "offsets": [ [ 1116, 1128 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "8950881_920_18", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 1341, 1344 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "8950881_920_19", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 1481, 1484 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "8950881_11676_20", "type": "Species", "text": [ "HIV-1" ], "offsets": [ [ 1612, 1617 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "11676" } ] }, { "id": "8950881_920_21", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 1748, 1751 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "8950881_9606_22", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1857, 1865 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "8950881_920_23", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 1915, 1918 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "8950881_MESH:D010146_24", "type": "Disease", "text": [ "Pain" ], "offsets": [ [ 2070, 2074 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010146" } ] }, { "id": "8950881_MESH:D015658_25", "type": "Disease", "text": [ "HIV-infected" ], "offsets": [ [ 2239, 2251 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015658" } ] }, { "id": "8950881_9606_26", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2252, 2260 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "8950881_MESH:D015658_27", "type": "Disease", "text": [ "HIV-1 disease" ], "offsets": [ [ 2297, 2310 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015658" } ] } ]

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[ { "id": "3878384_title", "type": "title", "text": [ "[Study on PGDH activity in human term placenta--relationship between PGDH activities and perinatal factors]." ], "offsets": [ [ 0, 108 ] ] }, { "id": "3878384_abstract", "type": "abstract", "text": [ "The high activity of 15-hydroxyprostaglandin dehydrogenase (PGDH) which catalyzes the first step in prostaglandin metabolism has been demonstrated in the human placenta. To investigate the role of placental PGDH (p-PGDH) in the perinatal period, PGDH activity was measured in 167 placentas of gestational ages 37 to 41 weeks. The activity was expressed as n mole/min/non heme protein of 15-keto-PGE2 which was produced by incubation of PGE2 and placental homogenate supernatant. The following data were obtained. p-PGDH activity was significantly lower at the 40 weeks of gestation than at other weeks. There was no difference in placental PGDH activity between cesarean section and vaginal delivery, and between the periods before and after onset labor of cesarean section. p-PGDH activity in the PGs administered group was higher than that in the non PGs group. p-PGDH activity of a male fetus was higher than that of a female. This suggests that p-PGDH activity is under the control of hormones. No relationship was observed between p-PGDH activity and other perinatal factors such as toxemia of pregnancy, parity, Apgar score, birth weight, placental weight, blood loss, and duration of labor." ], "offsets": [ [ 109, 1306 ] ] } ]

[ { "id": "3878384_3248_0", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 10, 14 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_9606_1", "type": "Species", "text": [ "human" ], "offsets": [ [ 27, 32 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "3878384_3248_2", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 69, 73 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_873_3", "type": "Gene", "text": [ "15-hydroxyprostaglandin dehydrogenase" ], "offsets": [ [ 130, 167 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "873" } ] }, { "id": "3878384_3248_4", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 169, 173 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_MESH:D011453_5", "type": "Chemical", "text": [ "prostaglandin" ], "offsets": [ [ 209, 222 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011453" } ] }, { "id": "3878384_9606_6", "type": "Species", "text": [ "human" ], "offsets": [ [ 263, 268 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "3878384_3248_7", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 316, 320 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_3248_8", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 324, 328 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_3248_9", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 355, 359 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_MESH:C026346_10", "type": "Chemical", "text": [ "15-keto-PGE2" ], "offsets": [ [ 496, 508 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C026346" } ] }, { "id": "3878384_MESH:D015232_11", "type": "Chemical", "text": [ "PGE2" ], "offsets": [ [ 545, 549 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015232" } ] }, { "id": "3878384_3248_12", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 624, 628 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_3248_13", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 749, 753 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_3248_14", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 886, 890 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_MESH:D010715_15", "type": "Chemical", "text": [ "PGs" ], "offsets": [ [ 907, 910 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010715" } ] }, { "id": "3878384_MESH:D010715_16", "type": "Chemical", "text": [ "PGs" ], "offsets": [ [ 962, 965 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010715" } ] }, { "id": "3878384_3248_17", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 975, 979 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_3248_18", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 1060, 1064 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_3248_19", "type": "Gene", "text": [ "PGDH" ], "offsets": [ [ 1147, 1151 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3248" } ] }, { "id": "3878384_MESH:D014115_20", "type": "Disease", "text": [ "toxemia" ], "offsets": [ [ 1197, 1204 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014115" } ] }, { "id": "3878384_MESH:D006473_21", "type": "Disease", "text": [ "blood loss" ], "offsets": [ [ 1272, 1282 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006473" } ] } ]

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[ { "id": "32778_title", "type": "title", "text": [ "Tardive dyskinesia and antiparkinsonian medication." ], "offsets": [ [ 0, 51 ] ] }, { "id": "32778_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 52, 52 ] ] } ]

[ { "id": "32778_MESH:D004409_0", "type": "Disease", "text": [ "Tardive dyskinesia" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004409" } ] } ]

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[ { "id": "27277867_title", "type": "title", "text": [ "Integrating neuroimmune systems in the neurobiology of depression." ], "offsets": [ [ 0, 66 ] ] }, { "id": "27277867_abstract", "type": "abstract", "text": [ "Data from clinical and preclinical studies indicate that immune dysregulation, specifically of inflammatory processes, is associated with symptoms of major depressive disorder (MDD). In particular, increased levels of circulating pro-inflammatory cytokines and concomitant activation of brain-resident microglia can lead to depressive behavioural symptoms. Repeated exposure to psychological stress has a profound impact on peripheral immune responses and perturbs the function of brain microglia, which may contribute to neurobiological changes underlying MDD. Here, we review these findings and discuss ongoing studies examining neuroimmune mechanisms that influence neuronal activity as well as synaptic plasticity. Interventions targeting immune-related cellular and molecular pathways may benefit subsets of MDD patients with immune dysregulation." ], "offsets": [ [ 67, 919 ] ] } ]

[ { "id": "27277867_MESH:D000275_0", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 55, 65 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "27277867_MESH:D003865_1", "type": "Disease", "text": [ "major depressive disorder" ], "offsets": [ [ 217, 242 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003865" } ] }, { "id": "27277867_MESH:D003865_2", "type": "Disease", "text": [ "MDD" ], "offsets": [ [ 244, 247 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003865" } ] }, { "id": "27277867_MESH:D000275_3", "type": "Disease", "text": [ "depressive behavioural symptoms" ], "offsets": [ [ 391, 422 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "27277867_MESH:D000079225_4", "type": "Disease", "text": [ "stress" ], "offsets": [ [ 459, 465 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000079225" } ] }, { "id": "27277867_MESH:D003865_5", "type": "Disease", "text": [ "MDD" ], "offsets": [ [ 624, 627 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003865" } ] }, { "id": "27277867_MESH:D003865_6", "type": "Disease", "text": [ "MDD" ], "offsets": [ [ 880, 883 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003865" } ] }, { "id": "27277867_9606_7", "type": "Species", "text": [ "patients" ], "offsets": [ [ 884, 892 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "27866527_title", "type": "title", "text": [ "[Association between daytime sleepiness and hypertension among patients with obstructive sleep apnea-hypopnea syndrome]." ], "offsets": [ [ 0, 120 ] ] }, { "id": "27866527_abstract", "type": "abstract", "text": [ "Objective: To assess the association between daytime sleepiness and hypertension among patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: A total of 1 958 patients from Sleep Medicine Center of West China Hospital between January 2015 and January 2016 were included in the study. All subjects underwent one night polysomnography (PSG) and Epworth sleep scale (ESS) was estimated. The patients were divided into non-OSAHS group[apnea-hypopnea index (AHI)<5/h]and OSAHS group (AHI>=5/h) based on PSG, and then OSAHS group was further divided into those with and without daytime sleepiness groups according to ESS score (the cut point of ESS was 14). The association between blood pressure and risk of suffering from hypertension among patients with different degree of daytime sleepiness was explored by binary logistic regression. Results: There were 1 580 men and 378 women among the included patients, the mean age was (44.3+-11.6) years old and the mean body mass index (BMI) was (26.4+-3.8) kg/m2. Among these patients, there were 267 non-OSAHS and 1 691 OSAHS patients (1 275 without daytime sleepiness and 416 with daytime sleepiness). The prevalence of hypertension was higher among OSAHS patients (53.9%vs 28.8%) than non-OSAHS group, and OSAHS patients had higher systolic blood pressure (SBP)[(126.3+-0.4) vs (116.3+-4.9) mmHg], diastolic blood pressure (DBP)[(82.4+-0.3) vs (78.1+-3.7) mmHg]and mean arterial pressure (MAP)[(97.0+-0.3) vs (90.9+-3.9) mmHg]than non-OSAHS group. And OSAHS with daytime sleepiness also had elevated DBP[(84.5+-0.6) vs (81.7+-0.3) mmHg]and MAP[(98.8+-0.6) vs (96.5+-0.3) mmHg]than those without sleepiness (all P<0.05). After controlling for age, sex, BMI, smoking, drinking, AHI and related sleep parameters, OSAHS combined with daytime sleepiness increased the odds of hypertension by 23% (OR=1.23, 95% CI: 1.01-1.65) compared to OSAHS without daytime sleepiness. Conclusion: The daytime sleepiness is an independent risk factor of hypertension in OSAHS patients." ], "offsets": [ [ 121, 2149 ] ] } ]

[ { "id": "27866527_MESH:D000077260_0", "type": "Disease", "text": [ "sleepiness" ], "offsets": [ [ 29, 39 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000077260" } ] }, { "id": "27866527_MESH:D006973_1", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 44, 56 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "27866527_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 63, 71 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_MESH:D020181_3", "type": "Disease", "text": [ "obstructive sleep apnea-hypopnea syndrome" ], "offsets": [ [ 77, 118 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D000077260_4", "type": "Disease", "text": [ "sleepiness" ], "offsets": [ [ 174, 184 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000077260" } ] }, { "id": "27866527_MESH:D006973_5", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 189, 201 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "27866527_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 208, 216 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_MESH:D020181_7", "type": "Disease", "text": [ "obstructive sleep apnea-hypopnea syndrome" ], "offsets": [ [ 222, 263 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D020181_8", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 265, 270 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_9606_9", "type": "Species", "text": [ "patients" ], "offsets": [ [ 299, 307 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 528, 536 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_MESH:D020181_11", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 559, 564 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D020181_12", "type": "Disease", "text": [ "apnea-hypopnea" ], "offsets": [ [ 571, 585 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D020181_13", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 606, 611 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D020181_14", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 652, 657 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D012893_15", "type": "Disease", "text": [ "daytime sleepiness" ], "offsets": [ [ 712, 730 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012893" } ] }, { "id": "27866527_MESH:D006973_16", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 858, 870 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "27866527_9606_17", "type": "Species", "text": [ "patients" ], "offsets": [ [ 877, 885 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_MESH:D012893_18", "type": "Disease", "text": [ "daytime sleepiness" ], "offsets": [ [ 911, 929 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012893" } ] }, { "id": "27866527_9606_19", "type": "Species", "text": [ "men" ], "offsets": [ [ 1000, 1003 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_9606_20", "type": "Species", "text": [ "women" ], "offsets": [ [ 1012, 1017 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_9606_21", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1037, 1045 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_9606_22", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1157, 1165 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_MESH:D020181_23", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 1186, 1191 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D020181_24", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 1202, 1207 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_9606_25", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1208, 1216 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_MESH:D012893_26", "type": "Disease", "text": [ "daytime sleepiness" ], "offsets": [ [ 1232, 1250 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012893" } ] }, { "id": "27866527_MESH:D012893_27", "type": "Disease", "text": [ "daytime sleepiness" ], "offsets": [ [ 1264, 1282 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012893" } ] }, { "id": "27866527_MESH:D006973_28", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 1303, 1315 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "27866527_MESH:D020181_29", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 1333, 1338 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_9606_30", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1339, 1347 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_MESH:D020181_31", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 1373, 1378 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D020181_32", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 1390, 1395 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_9606_33", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1396, 1404 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27866527_MESH:D020181_34", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 1619, 1624 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D020181_35", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 1636, 1641 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D012893_36", "type": "Disease", "text": [ "daytime sleepiness" ], "offsets": [ [ 1647, 1665 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012893" } ] }, { "id": "27866527_MESH:D000077260_37", "type": "Disease", "text": [ "sleepiness" ], "offsets": [ [ 1779, 1789 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000077260" } ] }, { "id": "27866527_MESH:D020181_38", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 1894, 1899 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D012893_39", "type": "Disease", "text": [ "daytime sleepiness" ], "offsets": [ [ 1914, 1932 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012893" } ] }, { "id": "27866527_MESH:D006973_40", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 1955, 1967 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "27866527_MESH:D020181_41", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 2016, 2021 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_MESH:D012893_42", "type": "Disease", "text": [ "daytime sleepiness" ], "offsets": [ [ 2030, 2048 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012893" } ] }, { "id": "27866527_MESH:D012893_43", "type": "Disease", "text": [ "daytime sleepiness" ], "offsets": [ [ 2066, 2084 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012893" } ] }, { "id": "27866527_MESH:D006973_44", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 2118, 2130 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006973" } ] }, { "id": "27866527_MESH:D020181_45", "type": "Disease", "text": [ "OSAHS" ], "offsets": [ [ 2134, 2139 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020181" } ] }, { "id": "27866527_9606_46", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2140, 2148 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "26550672_title", "type": "title", "text": [ "DHBs: South Canterbury to quit aged care." ], "offsets": [ [ 0, 41 ] ] }, { "id": "26550672_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 42, 42 ] ] } ]

[ { "id": "26550672_MESH:C003870_0", "type": "Chemical", "text": [ "DHBs" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C003870" } ] } ]

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[ { "id": "23730519_title", "type": "title", "text": [ "Endoscopic ultrasonography for pancreatic cancer: current and future perspectives." ], "offsets": [ [ 0, 82 ] ] }, { "id": "23730519_abstract", "type": "abstract", "text": [ "A suspected pancreatic lesion can be a difficult challenge for the clinician. In the last years we have witnessed tumultuous technological improvements of the radiological and nuclear medicine imaging. Taking this into account, we will try to delineate the new role of endoscopic ultrasound (EUS) in pancreatic imaging and to place it in a shareable diagnostic and staging algorithm of pancreatic cancer (PC). To date the most accurate imaging techniques for the PC remain contrast-enhanced computed tomography (CT) and EUS. The latter has the highest accuracy in detecting small lesions, in assessing tumor size and lymph nodes involvement, but helical CT or an up-to-date magnetic resonance imaging (MRI) must be the first choice in patients with a suspected pancreatic lesion. After this first step there is place for EUS as a second diagnostic level in several cases: negative results on CT/MRI scans and persistent strong clinical suspicion of PC, doubtful results on CT/MRI scans or need for cyto-histological confirmation. In the near future there will be great opportunities for the development of diagnostic and therapeutic EUS and pancreatic pathology could be the best testing bench." ], "offsets": [ [ 83, 1277 ] ] } ]

[ { "id": "23730519_MESH:D010190_0", "type": "Disease", "text": [ "pancreatic cancer" ], "offsets": [ [ 31, 48 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010190" } ] }, { "id": "23730519_MESH:D010195_1", "type": "Disease", "text": [ "pancreatic lesion" ], "offsets": [ [ 95, 112 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010195" } ] }, { "id": "23730519_MESH:D010190_2", "type": "Disease", "text": [ "pancreatic cancer" ], "offsets": [ [ 469, 486 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010190" } ] }, { "id": "23730519_MESH:D010190_3", "type": "Disease", "text": [ "PC" ], "offsets": [ [ 488, 490 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010190" } ] }, { "id": "23730519_MESH:D010190_4", "type": "Disease", "text": [ "PC" ], "offsets": [ [ 546, 548 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010190" } ] }, { "id": "23730519_MESH:D009369_5", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 685, 690 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "23730519_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 818, 826 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "23730519_MESH:D010195_7", "type": "Disease", "text": [ "pancreatic lesion" ], "offsets": [ [ 844, 861 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010195" } ] }, { "id": "23730519_MESH:D010190_8", "type": "Disease", "text": [ "PC" ], "offsets": [ [ 1032, 1034 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010190" } ] } ]

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[ { "id": "11313669_title", "type": "title", "text": [ "Phase II study of a high-dose ifosfamide-based chemotherapy regimen with growth factor rescue in recurrent aggressive NHL. High response rates and limited toxicity, but limited impact on long-term survival." ], "offsets": [ [ 0, 206 ] ] }, { "id": "11313669_abstract", "type": "abstract", "text": [ "The purpose of the study was to evaluate in patients with recurrent intermediate-grade NHL, the tolerance to and efficacy of an intensive salvage regimen consisting of high doses of ifosfamide, etoposide and mitoxantrone with G-CSF support, followed by autologous stem cell transplantation and to identify prognostic factors for survival in patients with recurrent aggressive lymphoma. Patients with recurrent intermediate-grade NHL under the age of 60 years were eligible. Induction consisted of ifosfamide 10 g/m(2) and etoposide 900 mg/m(2) with G-CSF 5 microg/kg twice a day. Upon recovery, patients underwent stem cell apheresis. Patients achieving complete remission (CR) underwent autologous stem cell transplantation using BEAM conditioning. Those with partial remission (PR) received treatment with ifosfamide 10 g/m(2), mitoxantrone 20 mg/m(2) and G-CSF 5 microg/kg. Those with CR received BEAM, those with PR received cyclophosphamide 4.5 g/m(2), etoposide 1200 mg/m(2) and cisplatin 135 mg/m(2) with stem cell rescue followed by BEAM. Antibiotic prophylaxis was given with all treatment cycles. The results were compared with those obtained in a prior study that used MINE-ESHAP salvage. Forty-four patients with recurrent intermediate-grade NHL were enrolled between March 1994 and September 1996. Median age was 50 years (24-61). Eleven patients had transformed lymphoma and seven had a T cell phenotype. Response rate to the high-dose ifosfamide regimen was 77% +/- 12% after two cycles and the complete response rate was 41% +/- 14%. Myelosuppression was profound but short. Median nadir ANC was 0 and the median duration of ANC <0.5 x 10(9)/l was 6 days (range 3-12). No severe infections occurred; 55% of the patients required blood transfusion and 42% required platelet transfusions. Myelosuppression and transfusion requirements were similar after the first and second cycles. Thirty-five of the 44 patients proceeded to autologous stem cell transplantation and one transplant-related death occurred. With a median follow-up of 52 months, progression-free survival at 2 years is 38% +/- 14% and survival is 52% +/- 15%. Data from these 44 patients were pooled with data on 53 patients who had received salvage treatment with MINE-ESHAP, for a multivariate analysis of prognostic factors. In multivariate analysis, serum LDH was strongly associated with survival. The use of a more intensive salvage regimen, did not result in a significant increase in long-term outcome, despite a high response rate. In conclusion, duration of treatment, response rates, treatment-related mortality and survival compare favorably with previous salvage regimens, but recurrence remains a major problem. Long-term survival in recurrent large cell lymphoma is influenced more by disease characteristics than by the type of salvage regimen used." ], "offsets": [ [ 207, 3052 ] ] } ]

[ { "id": "11313669_MESH:D007069_0", "type": "Chemical", "text": [ "ifosfamide" ], "offsets": [ [ 30, 40 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007069" } ] }, { "id": "11313669_MESH:D064420_1", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 155, 163 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064420" } ] }, { "id": "11313669_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 251, 259 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_MESH:D007069_3", "type": "Chemical", "text": [ "ifosfamide" ], "offsets": [ [ 389, 399 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007069" } ] }, { "id": "11313669_MESH:D005047_4", "type": "Chemical", "text": [ "etoposide" ], "offsets": [ [ 401, 410 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005047" } ] }, { "id": "11313669_MESH:D008942_5", "type": "Chemical", "text": [ "mitoxantrone" ], "offsets": [ [ 415, 427 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008942" } ] }, { "id": "11313669_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 548, 556 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_MESH:D008223_7", "type": "Disease", "text": [ "aggressive lymphoma" ], "offsets": [ [ 572, 591 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008223" } ] }, { "id": "11313669_9606_8", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 593, 601 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_MESH:D007069_9", "type": "Chemical", "text": [ "ifosfamide" ], "offsets": [ [ 704, 714 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007069" } ] }, { "id": "11313669_MESH:D005047_10", "type": "Chemical", "text": [ "etoposide" ], "offsets": [ [ 729, 738 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005047" } ] }, { "id": "11313669_9606_11", "type": "Species", "text": [ "patients" ], "offsets": [ [ 802, 810 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_9606_12", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 842, 850 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_MESH:D007069_13", "type": "Chemical", "text": [ "ifosfamide" ], "offsets": [ [ 1015, 1025 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007069" } ] }, { "id": "11313669_MESH:D008942_14", "type": "Chemical", "text": [ "mitoxantrone" ], "offsets": [ [ 1037, 1049 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008942" } ] }, { "id": "11313669_MESH:D003520_15", "type": "Chemical", "text": [ "cyclophosphamide" ], "offsets": [ [ 1136, 1152 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003520" } ] }, { "id": "11313669_MESH:D005047_16", "type": "Chemical", "text": [ "etoposide" ], "offsets": [ [ 1165, 1174 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005047" } ] }, { "id": "11313669_MESH:D002945_17", "type": "Chemical", "text": [ "cisplatin" ], "offsets": [ [ 1192, 1201 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002945" } ] }, { "id": "11313669_MESH:C056644_18", "type": "Chemical", "text": [ "ESHAP" ], "offsets": [ [ 1392, 1397 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C056644" } ] }, { "id": "11313669_9606_19", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1418, 1426 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_9606_20", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1558, 1566 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_MESH:D008223_21", "type": "Disease", "text": [ "lymphoma" ], "offsets": [ [ 1583, 1591 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008223" } ] }, { "id": "11313669_MESH:D007069_22", "type": "Chemical", "text": [ "ifosfamide" ], "offsets": [ [ 1657, 1667 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007069" } ] }, { "id": "11313669_MESH:D001855_23", "type": "Disease", "text": [ "Myelosuppression" ], "offsets": [ [ 1757, 1773 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001855" } ] }, { "id": "11313669_MESH:D007239_24", "type": "Disease", "text": [ "infections" ], "offsets": [ [ 1902, 1912 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "11313669_9606_25", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1934, 1942 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_MESH:D001855_26", "type": "Disease", "text": [ "Myelosuppression" ], "offsets": [ [ 2010, 2026 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001855" } ] }, { "id": "11313669_9606_27", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2126, 2134 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_MESH:D003643_28", "type": "Disease", "text": [ "death" ], "offsets": [ [ 2212, 2217 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "11313669_9606_29", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2366, 2374 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_9606_30", "type": "Species", "text": [ "patients" ], "offsets": [ [ 2403, 2411 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11313669_MESH:C056644_31", "type": "Chemical", "text": [ "ESHAP" ], "offsets": [ [ 2457, 2462 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C056644" } ] }, { "id": "11313669_MESH:D003643_32", "type": "Disease", "text": [ "mortality" ], "offsets": [ [ 2800, 2809 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "11313669_MESH:D008223_33", "type": "Disease", "text": [ "lymphoma" ], "offsets": [ [ 2956, 2964 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008223" } ] } ]

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[ { "id": "12460960_title", "type": "title", "text": [ "Motor vehicle and fall related deaths among older Americans 1990-98: sex, race, and ethnic disparities." ], "offsets": [ [ 0, 103 ] ] }, { "id": "12460960_abstract", "type": "abstract", "text": [ "OBJECTIVES: To examine differences in motor vehicle and fall related death rates among older adults by sex, race, and ethnicity. METHODS: Annual mortality tapes for 1990-98 provided demographic data including race and ethnicity, date, and cause of death. Trend analyses were conducted using Poisson regression. RESULTS: From 1990-98, overall motor vehicle related death rates remained stable while death rates from unintentional falls increased. Motor vehicle and fall related death rates were higher among men. Motor vehicle related death rates were higher among people of color while fall related death rates were higher among whites. Among whites, fall death rates increased significantly during the study period, with an annual relative increase of 3.6% for men and 3.2% for women. CONCLUSIONS: The risk of death from motor vehicle and fall related injuries among older adults differed by sex, race and ethnicity, results obscured by simple age and sex specific death rates. This study found important patterns and disparities in these death rates by race and ethnicity useful for identifying high risk groups and guiding prevention strategies." ], "offsets": [ [ 104, 1252 ] ] } ]

[ { "id": "12460960_MESH:D003643_0", "type": "Disease", "text": [ "deaths" ], "offsets": [ [ 31, 37 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_MESH:D003643_1", "type": "Disease", "text": [ "death" ], "offsets": [ [ 173, 178 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_MESH:D003643_2", "type": "Disease", "text": [ "death" ], "offsets": [ [ 352, 357 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_MESH:D003643_3", "type": "Disease", "text": [ "death" ], "offsets": [ [ 468, 473 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_MESH:D003643_4", "type": "Disease", "text": [ "death" ], "offsets": [ [ 502, 507 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_MESH:D003643_5", "type": "Disease", "text": [ "death" ], "offsets": [ [ 581, 586 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_9606_6", "type": "Species", "text": [ "men" ], "offsets": [ [ 611, 614 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12460960_MESH:D003643_7", "type": "Disease", "text": [ "death" ], "offsets": [ [ 638, 643 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_9606_8", "type": "Species", "text": [ "people" ], "offsets": [ [ 668, 674 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12460960_MESH:D003643_9", "type": "Disease", "text": [ "death" ], "offsets": [ [ 703, 708 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_MESH:D003643_10", "type": "Disease", "text": [ "death" ], "offsets": [ [ 760, 765 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_9606_11", "type": "Species", "text": [ "men" ], "offsets": [ [ 866, 869 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12460960_9606_12", "type": "Species", "text": [ "women" ], "offsets": [ [ 883, 888 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "12460960_MESH:D003643_13", "type": "Disease", "text": [ "death" ], "offsets": [ [ 915, 920 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_MESH:D003643_14", "type": "Disease", "text": [ "death" ], "offsets": [ [ 1070, 1075 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "12460960_MESH:D003643_15", "type": "Disease", "text": [ "death" ], "offsets": [ [ 1144, 1149 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] } ]

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[ { "id": "8254502_title", "type": "title", "text": [ "Charge inactivation in the membrane of intact frog striated muscle fibers." ], "offsets": [ [ 0, 74 ] ] }, { "id": "8254502_abstract", "type": "abstract", "text": [ "1. Charge movements were compared in normally polarized and depolarized intact frog muscle fibres under voltage clamp. 2. The membrane capacitance was linear through positive control steps made consistently from a holding voltage of -10 mV, in agreement with earlier reports from cut fibres. 3. A shift in holding voltage from -90 to -10 mV reduced both the absolute amount and the voltage dependence of charge movement elicited by voltage steps imposed from a fixed conditioning voltage of -180 mV. The charge transferred by steps from -180 to -20 mV was 43.8 +/- 1.14 nC/microF in fully polarized fibres and 21.7 +/- 1.49 nC/microF in the same depolarized fibres (means +/- S.E. of the mean; four fibres). 4. Charge movement in response to steps from -90 to -20 mV increased from 10.4 +/- 1.60 nC/microF to 28.4 +/- 2.42 nC/microF (five fibres) within 30s of changing the holding voltage from -10 to -90 mV. 5. The same fibres also showed significant charge movement between voltages of -180 and -90 mV. However, shifts in holding voltage did not significantly alter the maximum value of this charge, around 10-11 nC/microF. 6. Membrane capacitance as measured by small steps to a voltage of -90 mV remained constant despite holding potential changes, or lidocaine (10 mM) treatment. 7. The same results were obtained whether the above procedures were applied to fibres exposed to normal extracellular [Ca2+], or in Ca(2+)-free media. In both cases tubular cable corrections did not affect the results. 8. These findings suggest independent charge I and charge II systems in which inactivation of charge I is not associated with its interconversion into charge II." ], "offsets": [ [ 75, 1741 ] ] } ]

[ { "id": "8254502_MESH:D008012_0", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 1332, 1341 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008012" } ] }, { "id": "8254502_MESH:D000069285_1", "type": "Chemical", "text": [ "Ca2+" ], "offsets": [ [ 1480, 1484 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000069285" } ] } ]

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[ { "id": "15892687_title", "type": "title", "text": [ "Antitumour quinones." ], "offsets": [ [ 0, 20 ] ] }, { "id": "15892687_abstract", "type": "abstract", "text": [ "Quinones still comprise one of the largest classes of antitumour agents. For example, the anthracycline antibiotics are among the most utilised anticancer agents ever developed. Many other quinones were tested for their anticancer activity. Though there are general and well-established mechanisms for quinone toxicity, the exact contribution of the quinone moiety to the cytotoxic effect remains frequently uncertain. However, DNA represents the main target for quinoid antitumour agents and most of them belong to the groups of DNA intercalating and/or alkylating agents. But also other cellular structures such as heat shock protein 90 or telomerase have been identified as targets for quinoid compounds." ], "offsets": [ [ 21, 728 ] ] } ]

[ { "id": "15892687_-_0", "type": "Chemical", "text": [ "Antitumour quinones" ], "offsets": [ [ 0, 19 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "15892687_MESH:D011809_1", "type": "Chemical", "text": [ "Quinones" ], "offsets": [ [ 21, 29 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011809" } ] }, { "id": "15892687_MESH:D018943_2", "type": "Chemical", "text": [ "anthracycline" ], "offsets": [ [ 111, 124 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018943" } ] }, { "id": "15892687_MESH:D011809_3", "type": "Chemical", "text": [ "quinones" ], "offsets": [ [ 210, 218 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011809" } ] }, { "id": "15892687_MESH:C004532_4", "type": "Chemical", "text": [ "quinone" ], "offsets": [ [ 323, 330 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C004532" } ] }, { "id": "15892687_MESH:D064420_5", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 331, 339 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064420" } ] }, { "id": "15892687_MESH:C004532_6", "type": "Chemical", "text": [ "quinone" ], "offsets": [ [ 371, 378 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C004532" } ] }, { "id": "15892687_-_7", "type": "Chemical", "text": [ "quinoid" ], "offsets": [ [ 484, 491 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "15892687_-_8", "type": "Chemical", "text": [ "quinoid" ], "offsets": [ [ 710, 717 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "11315111_title", "type": "title", "text": [ "Regulation of nitrogenase in the photosynthetic bacterium Rhodobacter sphaeroides containing draTG and nifHDK genes from Rhodobacter capsulatus." ], "offsets": [ [ 0, 144 ] ] }, { "id": "11315111_abstract", "type": "abstract", "text": [ "The photosynthetic bacteria Rhodobacter capsulatus and Rhodospirillum rubrum regulate their nitrogenase activity by the reversible ADP-ribosylation of nitrogenase Fe-protein in response to ammonium addition or darkness. This regulation is mediated by two enzymes, dinitrogenase reductase ADP-ribosyl transferase (DRAT) and dinitrogenase reductase activating glycohydrolase (DRAG). Recently, we demonstrated that another photosynthetic bacterium, Rhodobacter sphaeroides, appears to have no draTG genes, and no evidence of Fe-protein ADP-ribosylation was found in this bacterium under a variety of growth and incubation conditions. Here we show that four different strains of Rba. sphaeroides are incapable of modifying Fe-protein, whereas four out of five Rba. capsulatus strains possess this ability. Introduction of Rba. capsulatus draTG and nifHDK (structural genes for nitrogenase proteins) into Rba. sphaeroides had no effect on in vivo nitrogenase activity and on nitrogenase switch-off by ammonium. However, transfer of draTG from Rba. capsulatus was sufficient to confer on Rba. sphaeroides the ability to reversibly modify the nitrogenase Fe-protein in response to either ammonium addition or darkness. These data suggest that Rba. sphaeroides, which lacks DRAT and DRAG, possesses all the elements necessary for the transduction of signals generated by ammonium or darkness to these proteins." ], "offsets": [ [ 145, 1547 ] ] } ]

[ { "id": "11315111_1063_0", "type": "Species", "text": [ "Rhodobacter sphaeroides" ], "offsets": [ [ 58, 81 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1063" } ] }, { "id": "11315111_1061_1", "type": "Species", "text": [ "Rhodobacter capsulatus" ], "offsets": [ [ 121, 143 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1061" } ] }, { "id": "11315111_1061_2", "type": "Species", "text": [ "Rhodobacter capsulatus" ], "offsets": [ [ 173, 195 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1061" } ] }, { "id": "11315111_1085_3", "type": "Species", "text": [ "Rhodospirillum rubrum" ], "offsets": [ [ 200, 221 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1085" } ] }, { "id": "11315111_MESH:D064751_4", "type": "Chemical", "text": [ "ammonium" ], "offsets": [ [ 334, 342 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064751" } ] }, { "id": "11315111_1063_5", "type": "Species", "text": [ "Rhodobacter sphaeroides" ], "offsets": [ [ 591, 614 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1063" } ] }, { "id": "11315111_-_6", "type": "Chemical", "text": [ "sphaeroides" ], "offsets": [ [ 1050, 1061 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "11315111_MESH:D064751_7", "type": "Chemical", "text": [ "ammonium" ], "offsets": [ [ 1141, 1149 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064751" } ] }, { "id": "11315111_-_8", "type": "Chemical", "text": [ "draTG" ], "offsets": [ [ 1172, 1177 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "11315111_-_9", "type": "Chemical", "text": [ "sphaeroides" ], "offsets": [ [ 1232, 1243 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "11315111_MESH:D064751_10", "type": "Chemical", "text": [ "ammonium" ], "offsets": [ [ 1326, 1334 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064751" } ] }, { "id": "11315111_MESH:D064751_11", "type": "Chemical", "text": [ "ammonium" ], "offsets": [ [ 1508, 1516 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064751" } ] } ]

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[ { "id": "36386077_title", "type": "title", "text": [ "CTLA4 Gene Polymorphism and its Association with Disease Occurrence, Clinical Manifestations, Serum Markers and Cytokine Levels in SLE Patients from North India." ], "offsets": [ [ 0, 161 ] ] }, { "id": "36386077_abstract", "type": "abstract", "text": [ "Background: Cytotoxic T lymphocyte-associated protein-4 (CTLA-4) or CD152 is an inhibitory receptor expressed constitutively on CD4+CD25+ T regulatory lymphocytes (Treg) and transiently on activated CD4+ and CD8+ T lymphocytes. Association of CTLA4 gene polymorphisms with Systemic Lupus Erythematosus (SLE) has been reported in south Indians, but not in north Indians. This study aims to investigate CTLA4 gene polymorphism and its association with the occurrence of SLE, its clinical manifestation and serological markers in north Indians. Methods: This cross sectional study was done in a tertiary health care centre in north India. Patients reporting to the hospital and diagnosed with systemic lupus erythematosus were included in study. +49 A/G (snp- rs231775) CTLA4 gene polymorphism was analysed in 41 SLE patients and 21 matched healthy controls by real time PCR method. ANA (Antinuclear Antibody), anti dsDNA, Interferon-gamma (IFN- gamma), TGF-beta, IL-10 were measured by ELISA kits. Complement (C3 and C4) and immunoglobulins (IgA, IgG, IgM) estimation were done with the turbidometry method. Chi-square test was used for comparison between groups and odds ratio with 95% confidence interval was calculated to estimate the associated risk. Results: A/A genotype was most common (51.2%) followed by the A/G genotype (46.3%) and G/G genotype (2.4%, detected in only 1 patient). The frequency of A allele was 74.4%, while of G allele was only 25.6%. A/G genotype SLE patients showed a higher risk (odds ratio 37.5, 95% CI- 6.048-232.51) of developing edema compared to A/A genotype patients. There was no statistically significant association of various CTLA4 genotypes with the occurrence of SLE and serum markers. Conclusions: A/A was the most common CTLA4 genotype in both SLE patients and healthy controls of north India. Contrary to the previous report in south Indians, there was no statistically significant association between CTLA4 genotype and occurrence of SLE in north Indians. Only the presence of generalised edema was found significantly associated with the A/G genotype." ], "offsets": [ [ 162, 2258 ] ] } ]

[ { "id": "36386077_1493_0", "type": "Gene", "text": [ "CTLA4" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_MESH:D008180_1", "type": "Disease", "text": [ "SLE" ], "offsets": [ [ 131, 134 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_9606_2", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 135, 143 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36386077_1493_3", "type": "Gene", "text": [ "Cytotoxic T lymphocyte-associated protein-4" ], "offsets": [ [ 174, 217 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_1493_4", "type": "Gene", "text": [ "CTLA-4" ], "offsets": [ [ 219, 225 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_1493_5", "type": "Gene", "text": [ "CD152" ], "offsets": [ [ 230, 235 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_920_6", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 290, 293 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "36386077_3559_7", "type": "Gene", "text": [ "CD25" ], "offsets": [ [ 294, 298 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3559" } ] }, { "id": "36386077_920_8", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 361, 364 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "36386077_925_9", "type": "Gene", "text": [ "CD8" ], "offsets": [ [ 370, 373 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "925" } ] }, { "id": "36386077_1493_10", "type": "Gene", "text": [ "CTLA4" ], "offsets": [ [ 405, 410 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_MESH:D008180_11", "type": "Disease", "text": [ "Systemic Lupus Erythematosus" ], "offsets": [ [ 435, 463 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_MESH:D008180_12", "type": "Disease", "text": [ "SLE" ], "offsets": [ [ 465, 468 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_1493_13", "type": "Gene", "text": [ "CTLA4" ], "offsets": [ [ 563, 568 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_MESH:D008180_14", "type": "Disease", "text": [ "SLE" ], "offsets": [ [ 630, 633 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_9606_15", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 798, 806 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36386077_MESH:D008180_16", "type": "Disease", "text": [ "systemic lupus erythematosus" ], "offsets": [ [ 852, 880 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_tmVar:c|SUB|A|+49|G;HGVS:c.+49A>G;VariantGroup:0;CorrespondingGene:1493;RS#:231775;CorrespondingSpecies:9606;CA#:126974_17", "type": "DNAMutation", "text": [ "+49 A/G" ], "offsets": [ [ 905, 912 ] ], "normalized": [ { "db_name": "tmVar", "db_id": "tmVar:c|SUB|A|+49|G;HGVS:c.+49A>G;VariantGroup:0;CorrespondingGene:1493;RS#:231775;CorrespondingSpecies:9606;CA#:126974" } ] }, { "id": "36386077_tmVar:rs231775;VariantGroup:0;CorrespondingGene:1493;RS#:231775;CorrespondingSpecies:9606_18", "type": "SNP", "text": [ "rs231775" ], "offsets": [ [ 919, 927 ] ], "normalized": [ { "db_name": "unknown", "db_id": "tmVar:rs231775;VariantGroup:0;CorrespondingGene:1493;RS#:231775;CorrespondingSpecies:9606" } ] }, { "id": "36386077_1493_19", "type": "Gene", "text": [ "CTLA4" ], "offsets": [ [ 929, 934 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_MESH:D008180_20", "type": "Disease", "text": [ "SLE" ], "offsets": [ [ 972, 975 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_9606_21", "type": "Species", "text": [ "patients" ], "offsets": [ [ 976, 984 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36386077_3458_22", "type": "Gene", "text": [ "IFN- gamma" ], "offsets": [ [ 1100, 1110 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3458" } ] }, { "id": "36386077_7040_23", "type": "Gene", "text": [ "TGF-beta" ], "offsets": [ [ 1113, 1121 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "7040" } ] }, { "id": "36386077_3586_24", "type": "Gene", "text": [ "IL-10" ], "offsets": [ [ 1123, 1128 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "3586" } ] }, { "id": "36386077_tmVar:c|SUB|A||G;VariantGroup:1;CorrespondingGene:1493;CorrespondingSpecies:9606_25", "type": "DNAMutation", "text": [ "A/G" ], "offsets": [ [ 1477, 1480 ] ], "normalized": [ { "db_name": "tmVar", "db_id": "tmVar:c|SUB|A||G;VariantGroup:1;CorrespondingGene:1493;CorrespondingSpecies:9606" } ] }, { "id": "36386077_9606_26", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1541, 1548 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36386077_tmVar:c|SUB|A||G;VariantGroup:1;CorrespondingGene:1493;CorrespondingSpecies:9606_27", "type": "DNAMutation", "text": [ "A/G" ], "offsets": [ [ 1622, 1625 ] ], "normalized": [ { "db_name": "tmVar", "db_id": "tmVar:c|SUB|A||G;VariantGroup:1;CorrespondingGene:1493;CorrespondingSpecies:9606" } ] }, { "id": "36386077_MESH:D008180_28", "type": "Disease", "text": [ "SLE" ], "offsets": [ [ 1635, 1638 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_9606_29", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1639, 1647 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36386077_MESH:D004487_30", "type": "Disease", "text": [ "edema" ], "offsets": [ [ 1723, 1728 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004487" } ] }, { "id": "36386077_9606_31", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1754, 1762 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36386077_1493_32", "type": "Gene", "text": [ "CTLA4" ], "offsets": [ [ 1826, 1831 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_MESH:D008180_33", "type": "Disease", "text": [ "SLE" ], "offsets": [ [ 1865, 1868 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_1493_34", "type": "Gene", "text": [ "CTLA4" ], "offsets": [ [ 1925, 1930 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_MESH:D008180_35", "type": "Disease", "text": [ "SLE" ], "offsets": [ [ 1948, 1951 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_9606_36", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1952, 1960 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36386077_1493_37", "type": "Gene", "text": [ "CTLA4" ], "offsets": [ [ 2107, 2112 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "1493" } ] }, { "id": "36386077_MESH:D008180_38", "type": "Disease", "text": [ "SLE" ], "offsets": [ [ 2140, 2143 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008180" } ] }, { "id": "36386077_MESH:D004487_39", "type": "Disease", "text": [ "edema" ], "offsets": [ [ 2195, 2200 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004487" } ] }, { "id": "36386077_tmVar:c|SUB|A||G;VariantGroup:1;CorrespondingGene:1493;CorrespondingSpecies:9606_40", "type": "DNAMutation", "text": [ "A/G" ], "offsets": [ [ 2245, 2248 ] ], "normalized": [ { "db_name": "tmVar", "db_id": "tmVar:c|SUB|A||G;VariantGroup:1;CorrespondingGene:1493;CorrespondingSpecies:9606" } ] } ]

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[ { "id": "11178769_title", "type": "title", "text": [ "The effect of gases in the intraperitoneal space on cytokine response and bacterial translocation in a rat model." ], "offsets": [ [ 0, 113 ] ] }, { "id": "11178769_abstract", "type": "abstract", "text": [ "BACKGROUND: The aim of this study was to examine cytokine response and bacterial translocation after exposure of the intraperitoneal space to carbon dioxide (CO2), helium (He), and air (Air) in a rat model. METHODS: For this study, 120 Sprague-Dawley rats underwent anesthesia only (Control), 10 mmHg pneumoperitoneum (PP), or abdominal wall lift (AWL). The rats were divided into five groups according to experimental procedure: Control, PP-CO2, AWL-CO2, AWL-He, and AWL-Air. At 0, 3, 6, and 24 h after the procedures, the levels of interleukin 1beta (IL-1beta) and interleukin 6 (IL-6) in both plasma and peritoneal lavage fluid (PLF) were measured, and the translocation of bacteria to the mesenteric lymph nodes was evaluated. RESULTS: The plasma IL-1beta and IL-6 levels in the PP-CO2, AWL-CO2, and AWL-He groups were significantly lower than those in AWL-Air group at 6 h (p < 0.05). The PLF IL-1beta (at 3, 6, and 24 h) and IL-6 (at 6 h) levels in the AWL-CO2 group were significantly lower than those in the AWL-Air group (p < 0.05). There were no significant differences in IL-1beta and IL-6 responses among the PP-CO2, AWL-CO2, and AWL-He groups. The AWL-CO2 and PP-CO2 groups had lower incidences of bacterial translocation than did the AWL-Air group (p < 0.05). CONCLUSIONS: The results from this study suggest that the gas in the intraperitoneal space, but not the increased intraabdominal pressure, causes the alterations in host cytokine response and bacterial translocation. Carbon dioxide may play a primary role in the reduced immune response associated with laparoscopic surgery." ], "offsets": [ [ 114, 1712 ] ] } ]

[ { "id": "11178769_10116_0", "type": "Species", "text": [ "rat" ], "offsets": [ [ 103, 106 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "11178769_MESH:D002245_1", "type": "Chemical", "text": [ "carbon dioxide" ], "offsets": [ [ 256, 270 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D002245_2", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 272, 275 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D006371_3", "type": "Chemical", "text": [ "helium" ], "offsets": [ [ 278, 284 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006371" } ] }, { "id": "11178769_MESH:D006371_4", "type": "Chemical", "text": [ "He" ], "offsets": [ [ 286, 288 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006371" } ] }, { "id": "11178769_10116_5", "type": "Species", "text": [ "rat" ], "offsets": [ [ 310, 313 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "11178769_10116_6", "type": "Species", "text": [ "Sprague-Dawley rats" ], "offsets": [ [ 350, 369 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "11178769_MESH:D011027_7", "type": "Disease", "text": [ "pneumoperitoneum" ], "offsets": [ [ 415, 431 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011027" } ] }, { "id": "11178769_MESH:D011027_8", "type": "Disease", "text": [ "PP" ], "offsets": [ [ 433, 435 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011027" } ] }, { "id": "11178769_10116_9", "type": "Species", "text": [ "rats" ], "offsets": [ [ 472, 476 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "11178769_MESH:D011027_10", "type": "Disease", "text": [ "PP" ], "offsets": [ [ 553, 555 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011027" } ] }, { "id": "11178769_MESH:D002245_11", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 556, 559 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D002245_12", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 565, 568 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D006371_13", "type": "Chemical", "text": [ "He" ], "offsets": [ [ 574, 576 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006371" } ] }, { "id": "11178769_24494_14", "type": "Gene", "text": [ "interleukin 1beta" ], "offsets": [ [ 648, 665 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24494" } ] }, { "id": "11178769_24493_15", "type": "Gene", "text": [ "IL-1beta" ], "offsets": [ [ 667, 675 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24493" } ] }, { "id": "11178769_24498_16", "type": "Gene", "text": [ "interleukin 6" ], "offsets": [ [ 681, 694 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24498" } ] }, { "id": "11178769_24498_17", "type": "Gene", "text": [ "IL-6" ], "offsets": [ [ 696, 700 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24498" } ] }, { "id": "11178769_24493_18", "type": "Gene", "text": [ "IL-1beta" ], "offsets": [ [ 865, 873 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24493" } ] }, { "id": "11178769_24498_19", "type": "Gene", "text": [ "IL-6" ], "offsets": [ [ 878, 882 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24498" } ] }, { "id": "11178769_MESH:D011027_20", "type": "Disease", "text": [ "PP" ], "offsets": [ [ 897, 899 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011027" } ] }, { "id": "11178769_MESH:D002245_21", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 900, 903 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D002245_22", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 909, 912 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D006371_23", "type": "Chemical", "text": [ "He" ], "offsets": [ [ 922, 924 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006371" } ] }, { "id": "11178769_24493_24", "type": "Gene", "text": [ "IL-1beta" ], "offsets": [ [ 1012, 1020 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24493" } ] }, { "id": "11178769_24498_25", "type": "Gene", "text": [ "IL-6" ], "offsets": [ [ 1045, 1049 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24498" } ] }, { "id": "11178769_MESH:D002245_26", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 1077, 1080 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_24493_27", "type": "Gene", "text": [ "IL-1beta" ], "offsets": [ [ 1197, 1205 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24493" } ] }, { "id": "11178769_24498_28", "type": "Gene", "text": [ "IL-6" ], "offsets": [ [ 1210, 1214 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "24498" } ] }, { "id": "11178769_MESH:D011027_29", "type": "Disease", "text": [ "PP" ], "offsets": [ [ 1235, 1237 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011027" } ] }, { "id": "11178769_MESH:D002245_30", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 1238, 1241 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D002245_31", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 1247, 1250 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D006371_32", "type": "Chemical", "text": [ "He" ], "offsets": [ [ 1260, 1262 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006371" } ] }, { "id": "11178769_MESH:D002245_33", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 1279, 1282 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D011027_34", "type": "Disease", "text": [ "PP" ], "offsets": [ [ 1287, 1289 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011027" } ] }, { "id": "11178769_MESH:D002245_35", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 1290, 1293 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "11178769_MESH:D002245_36", "type": "Chemical", "text": [ "Carbon dioxide" ], "offsets": [ [ 1605, 1619 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] } ]

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[ { "id": "16247761_title", "type": "title", "text": [ "Toward a rational design of beta-peptide structures." ], "offsets": [ [ 0, 52 ] ] }, { "id": "16247761_abstract", "type": "abstract", "text": [ "Intrinsic conformational characteristics of beta-peptides built up from simple achiral and chiral beta-amino acid residues (i.e., HCO-beta-Ala-NH2, HCO-beta-Abu-NH2) were studied using quantum chemical calculations and 1H-NMR spectroscopy. A conformer-based systematic and uniform nomenclature was introduced to differentiate conformers. Geometry optimizations were performed on all homoconformers of both HCO-(beta-Ala)(k)-NH2 and HCO-(beta-Abu)(k)-NH2 (1 < or = k < or = 6) model systems at the RHF/3-21G and RHF/6-311++G(d, p) levels of theory. To test for accuracy and precision, additional computations were carried out at several levels of theory [e.g., RHF/6-31G(d), and B3LYP/6-311++G(d, p)]. To display the folding preference, the relative stability of selected conformers as function of the length of the polypeptide chain was determined. Ab initio population distribution of hexapeptides and the conformational ensemble of synthetic models composed of beta-Ala and beta-Abu studied using 1H-NMR in different solvents were compared at a range of temperatures. Helical preference induced by various steric effects of nonpolar side chains was tested using higher level ab initio methods for well-known model systems such as: HCO-(beta-HVal-beta-HAla-beta-HLeu)2-NH2, HCO-(ACHC)6-NH2, HCO-(trans-ACPC)6-NH2, and HCO-(cis-ACPC)6-NH2. The relative stabilities determined by theoretical methods agreed well with most experimental data, supporting the theory that the local conformational preference influenced by steric effects is a key determining factor of the global fold both in solution and in the gas phase." ], "offsets": [ [ 53, 1670 ] ] } ]

[ { "id": "16247761_-_0", "type": "Chemical", "text": [ "beta-amino acid" ], "offsets": [ [ 151, 166 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_-_1", "type": "Chemical", "text": [ "HCO-beta-Ala-NH2" ], "offsets": [ [ 183, 199 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_-_2", "type": "Chemical", "text": [ "HCO-beta-Abu-NH2" ], "offsets": [ [ 201, 217 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_-_3", "type": "Chemical", "text": [ "1H" ], "offsets": [ [ 272, 274 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_-_4", "type": "Chemical", "text": [ "HCO-(beta-Ala)" ], "offsets": [ [ 459, 473 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_-_5", "type": "Chemical", "text": [ "HCO-(beta-Abu)" ], "offsets": [ [ 485, 499 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_-_6", "type": "Chemical", "text": [ "1H" ], "offsets": [ [ 1052, 1054 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_MESH:D012497_7", "type": "Disease", "text": [ "beta-HVal-beta-HAla-beta-HLeu" ], "offsets": [ [ 1291, 1320 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012497" } ] }, { "id": "16247761_-_8", "type": "Chemical", "text": [ "HCO-(ACHC)6-NH2" ], "offsets": [ [ 1328, 1343 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_-_9", "type": "Chemical", "text": [ "HCO-(trans-ACPC)6-NH2" ], "offsets": [ [ 1345, 1366 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "16247761_-_10", "type": "Chemical", "text": [ "HCO-(cis-ACPC)6-NH2" ], "offsets": [ [ 1372, 1391 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "860809_title", "type": "title", "text": [ "Advanced nursing." ], "offsets": [ [ 0, 17 ] ] }, { "id": "860809_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 18, 18 ] ] } ]

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[ { "id": "34780805_title", "type": "title", "text": [ "Altered prevalence of pulp diagnoses in diabetes mellitus patients: A retrospective study." ], "offsets": [ [ 0, 90 ] ] }, { "id": "34780805_abstract", "type": "abstract", "text": [ "INTRODUCTION: Diabetes mellitus (DM) is a complex multisystemic disorder that affects an estimated 21 million Americans. No studies have evaluated the association of DM with the prevalence of each pulpal diagnosis. The objective of this study is to compare the prevalence of each pulp diagnosis including symptomatic irreversible pulpitis (SIP), asymptomatic irreversible pulpitis (AIP), reversible pulpitis (RP), normal pulp (NP) and pulp necrosis (PN) in DM patients against a non-diabetic control group. METHODS: The retrospective chart review was approved by Rutgers University Institutional Review Board. The prevalence of the diagnoses SIP, AIP, RP, NP and PN was calculated from AxiUm electronic health records at Rutgers School of Dental Medicine. Chi-square test was used to see the relationship between the two categorical variables. Second, binary logistic regression analyses were performed for each group. RESULTS: A total of 2979 teeth were diagnosed with pulp condition between April 2013 and November 2018. The total tooth number of DM patients was 682 whereas the tooth number of non-diabetic patients was 2,279. In the subgroup of younger than 40 years old, SIP is notably more prevalent in DM patients. In addition, the prevalence of PN in elderly DM patients (60-69 years old) was significantly higher than control group. CONCLUSION: The prevalence of SIP in DM patients was significantly higher compared to control group (younger than 40 years old), suggesting the possibility that DM condition could hypersensitize the subgroup of younger than 40 years old to pulpitis pain." ], "offsets": [ [ 91, 1687 ] ] } ]

[ { "id": "34780805_MESH:D003920_0", "type": "Disease", "text": [ "diabetes mellitus" ], "offsets": [ [ 40, 57 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 58, 66 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34780805_MESH:D003920_2", "type": "Disease", "text": [ "Diabetes mellitus" ], "offsets": [ [ 105, 122 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_MESH:D003920_3", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 124, 126 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_MESH:D012791_4", "type": "Disease", "text": [ "multisystemic disorder" ], "offsets": [ [ 141, 163 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012791" } ] }, { "id": "34780805_MESH:D003920_5", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 257, 259 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_MESH:D011671_6", "type": "Disease", "text": [ "pulpitis" ], "offsets": [ [ 421, 429 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011671" } ] }, { "id": "34780805_MESH:D011671_7", "type": "Disease", "text": [ "pulpitis" ], "offsets": [ [ 463, 471 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011671" } ] }, { "id": "34780805_MESH:D011671_8", "type": "Disease", "text": [ "pulpitis" ], "offsets": [ [ 490, 498 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011671" } ] }, { "id": "34780805_MESH:D009336_9", "type": "Disease", "text": [ "necrosis" ], "offsets": [ [ 531, 539 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009336" } ] }, { "id": "34780805_MESH:D003920_10", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 548, 550 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_9606_11", "type": "Species", "text": [ "patients" ], "offsets": [ [ 551, 559 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34780805_MESH:D003920_12", "type": "Disease", "text": [ "diabetic" ], "offsets": [ [ 574, 582 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_MESH:D003920_13", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 1140, 1142 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_9606_14", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1143, 1151 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34780805_MESH:D003920_15", "type": "Disease", "text": [ "diabetic" ], "offsets": [ [ 1192, 1200 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_9606_16", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1201, 1209 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34780805_MESH:D003920_17", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 1300, 1302 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_9606_18", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1303, 1311 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34780805_MESH:D003920_19", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 1358, 1360 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_9606_20", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1361, 1369 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34780805_MESH:D003920_21", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 1470, 1472 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_9606_22", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1473, 1481 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "34780805_MESH:D003920_23", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 1594, 1596 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "34780805_MESH:D011671_24", "type": "Disease", "text": [ "pulpitis pain" ], "offsets": [ [ 1673, 1686 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011671" } ] } ]

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[ { "id": "31424017_title", "type": "title", "text": [ "Sonication of antibiotic loaded cement spacers: A valuable technique for detection of infection persistence in two-stage revision for infected joint arthroplasty." ], "offsets": [ [ 0, 162 ] ] }, { "id": "31424017_abstract", "type": "abstract", "text": [ "We evaluated the diagnostic utility of sonication of antibiotic loaded cement spacers comparing with periprosthetic tissue cultures for the detection of persisting infection in 14 patients undergoing staged procedures. Sonication improved microbial detection of intraoperative cultures from 14.2% to 28.5% (P = 0.481). Routine sonication of spacers is recommended." ], "offsets": [ [ 163, 527 ] ] } ]

[ { "id": "31424017_MESH:D007239_0", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 86, 95 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "31424017_MESH:D007239_1", "type": "Disease", "text": [ "infected" ], "offsets": [ [ 134, 142 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "31424017_MESH:D007239_2", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 327, 336 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "31424017_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 343, 351 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "13609675_title", "type": "title", "text": [ "[Effect of aminazine on bile secretion by the liver]." ], "offsets": [ [ 0, 53 ] ] }, { "id": "13609675_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 54, 54 ] ] } ]

[ { "id": "13609675_MESH:D002746_0", "type": "Chemical", "text": [ "aminazine" ], "offsets": [ [ 11, 20 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002746" } ] } ]

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[ { "id": "4234173_title", "type": "title", "text": [ "[Microregional study of flaxedil action on the lumbar spinal cord]." ], "offsets": [ [ 0, 67 ] ] }, { "id": "4234173_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 68, 68 ] ] } ]

[ { "id": "4234173_MESH:D005703_0", "type": "Chemical", "text": [ "flaxedil" ], "offsets": [ [ 24, 32 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005703" } ] } ]

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[ { "id": "11510742_title", "type": "title", "text": [ "Experience with percutaneous dilational tracheostomy." ], "offsets": [ [ 0, 53 ] ] }, { "id": "11510742_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 54, 54 ] ] } ]

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[ { "id": "24860656_title", "type": "title", "text": [ "Point of care cutaneous imaging technology in melanoma screening and mole mapping." ], "offsets": [ [ 0, 82 ] ] }, { "id": "24860656_abstract", "type": "abstract", "text": [ "Melanoma is a malignancy of melanocytes or pigment-producing cells located predominantly in the skin. It is less common than other skin cancers but causes the greatest number of skin cancer-related deaths worldwide. The incidence of melanoma continues to increase and early detection is the most promising means of decreasing morbidity and mortality. Currently, physicians perform routine skin cancer screenings for melanoma without the benefit of imaging devices more advanced than handheld magnifiers or dermatoscopes. However, it is possible that the diagnosis of melanoma may be improved with technology that provides diagnostic discrimination beyond what is possible on routine inspection. This article reviews current and emerging technologies to aid in the diagnosis of melanoma. Ultimately, these advances may enhance the early diagnosis of melanoma." ], "offsets": [ [ 83, 941 ] ] } ]

[ { "id": "24860656_MESH:D008545_0", "type": "Disease", "text": [ "melanoma" ], "offsets": [ [ 46, 54 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008545" } ] }, { "id": "24860656_MESH:D008545_1", "type": "Disease", "text": [ "Melanoma" ], "offsets": [ [ 83, 91 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008545" } ] }, { "id": "24860656_MESH:D009369_2", "type": "Disease", "text": [ "malignancy" ], "offsets": [ [ 97, 107 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "24860656_MESH:D012878_3", "type": "Disease", "text": [ "skin cancers" ], "offsets": [ [ 214, 226 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012878" } ] }, { "id": "24860656_MESH:D012878_4", "type": "Disease", "text": [ "skin cancer" ], "offsets": [ [ 261, 272 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012878" } ] }, { "id": "24860656_MESH:D003643_5", "type": "Disease", "text": [ "deaths" ], "offsets": [ [ 281, 287 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "24860656_MESH:D008545_6", "type": "Disease", "text": [ "melanoma" ], "offsets": [ [ 316, 324 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008545" } ] }, { "id": "24860656_MESH:D003643_7", "type": "Disease", "text": [ "mortality" ], "offsets": [ [ 423, 432 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "24860656_MESH:D012878_8", "type": "Disease", "text": [ "skin cancer" ], "offsets": [ [ 472, 483 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012878" } ] }, { "id": "24860656_MESH:D008545_9", "type": "Disease", "text": [ "melanoma" ], "offsets": [ [ 499, 507 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008545" } ] }, { "id": "24860656_MESH:D008545_10", "type": "Disease", "text": [ "melanoma" ], "offsets": [ [ 650, 658 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008545" } ] }, { "id": "24860656_MESH:D008545_11", "type": "Disease", "text": [ "melanoma" ], "offsets": [ [ 860, 868 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008545" } ] }, { "id": "24860656_MESH:D008545_12", "type": "Disease", "text": [ "melanoma" ], "offsets": [ [ 932, 940 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008545" } ] } ]

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[ { "id": "28118544_title", "type": "title", "text": [ "Submicron Colloidosomes of Tunable Size and Wall Thickness." ], "offsets": [ [ 0, 59 ] ] }, { "id": "28118544_abstract", "type": "abstract", "text": [ "We present a simple method for the fabrication of colloidal capsules of different sizes ranging from below 100 nm up to one micron. The capsules are produced by self-assembling 5 nm gold nanoparticles at the interface of oil-in-water emulsion droplets. The size of the capsules is regulated by tuning the wetting properties of the nanoparticles by changing either the composition of their ligand shell or the composition of the oil phase. The modified wettability affects not only the size but also the thickness of capsule walls. The wall can be thin if it is made of a single layer of the nanoparticles or thick when composed of multilayers. The durability of such capsules is quite high, although it can be improved by chemical cross-linking with UV light. Such capsules have low permeability, so they can store a molecular cargo and then release it on demand." ], "offsets": [ [ 60, 923 ] ] } ]

[ { "id": "28118544_MESH:D009821_0", "type": "Chemical", "text": [ "oil" ], "offsets": [ [ 281, 284 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009821" } ] }, { "id": "28118544_MESH:D014867_1", "type": "Chemical", "text": [ "water" ], "offsets": [ [ 288, 293 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014867" } ] } ]

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[ { "id": "33085031_title", "type": "title", "text": [ "Correction to: Programmed death 1 ligand (PD-L1) in solid cancers after allogeneic hematopoietic stem cell transplantation: a retrospective analysis by the Nagasaki Transplant Group." ], "offsets": [ [ 0, 182 ] ] }, { "id": "33085031_abstract", "type": "abstract", "text": [ "In the original publication of the article, the authors would like to alter the color of characters in the Supplemental Table 1 and 2." ], "offsets": [ [ 183, 317 ] ] } ]

[ { "id": "33085031_29126_0", "type": "Gene", "text": [ "PD-L1" ], "offsets": [ [ 42, 47 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "29126" } ] }, { "id": "33085031_MESH:D009369_1", "type": "Disease", "text": [ "cancers" ], "offsets": [ [ 58, 65 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] } ]

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[ { "id": "28247000_title", "type": "title", "text": [ "Stable ankle joint fractures. Indications for operative or conservative treatment?" ], "offsets": [ [ 0, 82 ] ] }, { "id": "28247000_abstract", "type": "abstract", "text": [ "In German literature, ankle joint fractures are mostly classified in three groups according to Weber. In cases of the type A, the fracture line runs below, in cases of type B at height of the syndesmotic ligaments. C-type fractures are typically seen above this region. However, this practical and simple classification allows no inferences at accompanying injuries which in turn influence the functional outcome. We observed isolated fractures of the lateral malleolus in more than 60 % of all type B-fractures, as soon as in the majority the type A-fractures. Since isolated medial ankle fractures occur very rarely, careful exclusion of further injuries is advisable here. In order to differentiate stable ones from unstable type B ankle injuries, we carry out a manual stress test, if there is less than 2 mm fracture dislocation and a congruent ankle mortise. In this manner we could find that stable lateral ankle fractures are characterized with a combination of an intact dorsal syndesmotic and medial ligament. Stable type B and undisplaced type A fractures were treated conservatively with an ankle brace (Aircast?). Unstable ankle injuries were treated by ORIF. Conservative treatment for undisplaced medial malleolar fractures is recommended, if x-rays showed less than 2 mm dislocation which allows a tibio-talare impingement. Biomechanical investigations could prove a significant increase in ankle joint stability, when an axial load of 300 N was applied to various horizontal loads. The talus does not follow automatically a displaced fibular fracture. The dorsal syndesmotic and the medial deltoid ligaments control ankle joint stability." ], "offsets": [ [ 83, 1738 ] ] } ]

[ { "id": "28247000_MESH:D064386_0", "type": "Disease", "text": [ "ankle joint fractures" ], "offsets": [ [ 7, 28 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064386" } ] }, { "id": "28247000_MESH:D064386_1", "type": "Disease", "text": [ "ankle joint fractures" ], "offsets": [ [ 105, 126 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064386" } ] }, { "id": "28247000_MESH:D050723_2", "type": "Disease", "text": [ "fracture" ], "offsets": [ [ 213, 221 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050723" } ] }, { "id": "28247000_MESH:D050723_3", "type": "Disease", "text": [ "fractures" ], "offsets": [ [ 305, 314 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050723" } ] }, { "id": "28247000_MESH:D064386_4", "type": "Disease", "text": [ "fractures of the lateral malleolus" ], "offsets": [ [ 518, 552 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064386" } ] }, { "id": "28247000_MESH:D050723_5", "type": "Disease", "text": [ "B-fractures" ], "offsets": [ [ 583, 594 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050723" } ] }, { "id": "28247000_MESH:D050723_6", "type": "Disease", "text": [ "A-fractures" ], "offsets": [ [ 632, 643 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050723" } ] }, { "id": "28247000_MESH:D064386_7", "type": "Disease", "text": [ "ankle fractures" ], "offsets": [ [ 667, 682 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064386" } ] }, { "id": "28247000_MESH:D016512_8", "type": "Disease", "text": [ "ankle injuries" ], "offsets": [ [ 818, 832 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016512" } ] }, { "id": "28247000_MESH:D000072039_9", "type": "Disease", "text": [ "fracture dislocation" ], "offsets": [ [ 896, 916 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000072039" } ] }, { "id": "28247000_MESH:D064386_10", "type": "Disease", "text": [ "ankle fractures" ], "offsets": [ [ 997, 1012 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D064386" } ] }, { "id": "28247000_MESH:D050723_11", "type": "Disease", "text": [ "fractures" ], "offsets": [ [ 1140, 1149 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050723" } ] }, { "id": "28247000_MESH:D016512_12", "type": "Disease", "text": [ "ankle injuries" ], "offsets": [ [ 1219, 1233 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016512" } ] }, { "id": "28247000_MESH:D050723_13", "type": "Disease", "text": [ "fractures" ], "offsets": [ [ 1312, 1321 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050723" } ] }, { "id": "28247000_MESH:D050723_14", "type": "Disease", "text": [ "fracture" ], "offsets": [ [ 1642, 1650 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050723" } ] } ]

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[ { "id": "15097771_title", "type": "title", "text": [ "Possible errors in determining axial length changes during accommodation with the IOLMaster." ], "offsets": [ [ 0, 92 ] ] }, { "id": "15097771_abstract", "type": "abstract", "text": [ "PURPOSE: The Zeiss IOLMaster uses partial coherence interferometry to measure the optical path length within the eye. This is converted into the axial length. There are errors in measuring possible changes in axial length as a result of accommodation, because the instrument uses an average refractive index in the eye. We determined the likely extent of these errors. METHOD: Errors were estimated using Gullstrand's no. 1 schematic eyes. One set of these had the shell structure of the eyes, and another set had the gradient index structure specified by Gullstrand. RESULTS: Errors were 18 to 26 microm for an accommodation of 10.9 D. CONCLUSIONS: The worth of the IOLMaster would be increased if it used an equation for conversion from optical length to geometrical length that took into account variations in lens thickness and if it were able to be modified to provide component distances and the axial length using partial coherence tomography." ], "offsets": [ [ 93, 1043 ] ] } ]

[ { "id": "15097771_MESH:D000853_0", "type": "Disease", "text": [ "schematic eyes" ], "offsets": [ [ 517, 531 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000853" } ] } ]

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[ { "id": "23361868_title", "type": "title", "text": [ "Glutamate transporter type 3 knockout leads to decreased heart rate possibly via parasympathetic mechanism." ], "offsets": [ [ 0, 107 ] ] }, { "id": "23361868_abstract", "type": "abstract", "text": [ "Parasympathetic tone is a dominant neural regulator for basal heart rate. Glutamate transporters (EAAT) via their glutamate uptake functions regulate glutamate neurotransmission in the central nervous system. We showed that EAAT type 3 (EAAT3) knockout mice had a slower heart rate than wild-type mice when they were anesthetized. We design this study to determine whether non-anesthetized EAAT3 knockout mice have a slower heart rate and, if so, what may be the mechanism for this effect. Young adult EAAT3 knockout mice had slower heart rates than those of their littermate wild-type mice no matter whether they were awake or anesthetized. This difference was abolished by atropine, a parasympatholytic drug. Carbamylcholine chloride, a parasympathomimetic drug, equally effectively reduced the heart rates of wild-type and EAAT3 knockout mice. Positive immunostaining for EAAT3 was found in the area of nuclei deriving fibers for vagus nerve. There was no positive staining for the EAATs in the sinoatrial node. These results suggest that EAAT3 knockout mice have a slower heart rate at rest. This effect may be caused by an increased parasympathetic tone possibly due to increased glutamate neurotransmission in the central nervous system. These findings indicate that regulation of heart rate, a vital sign, is one of the EAAT biological functions." ], "offsets": [ [ 108, 1461 ] ] } ]

[ { "id": "23361868_MESH:D018698_0", "type": "Chemical", "text": [ "glutamate" ], "offsets": [ [ 222, 231 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018698" } ] }, { "id": "23361868_MESH:D018698_1", "type": "Chemical", "text": [ "glutamate" ], "offsets": [ [ 258, 267 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018698" } ] }, { "id": "23361868_20510_2", "type": "Gene", "text": [ "EAAT type 3" ], "offsets": [ [ 332, 343 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "20510" } ] }, { "id": "23361868_20510_3", "type": "Gene", "text": [ "EAAT3" ], "offsets": [ [ 345, 350 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "20510" } ] }, { "id": "23361868_10090_4", "type": "Species", "text": [ "mice" ], "offsets": [ [ 361, 365 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "23361868_10090_5", "type": "Species", "text": [ "mice" ], "offsets": [ [ 405, 409 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "23361868_20510_6", "type": "Gene", "text": [ "EAAT3" ], "offsets": [ [ 498, 503 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "20510" } ] }, { "id": "23361868_10090_7", "type": "Species", "text": [ "mice" ], "offsets": [ [ 513, 517 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "23361868_20510_8", "type": "Gene", "text": [ "EAAT3" ], "offsets": [ [ 610, 615 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "20510" } ] }, { "id": "23361868_10090_9", "type": "Species", "text": [ "mice" ], "offsets": [ [ 625, 629 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "23361868_10090_10", "type": "Species", "text": [ "mice" ], "offsets": [ [ 694, 698 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "23361868_MESH:D001285_11", "type": "Chemical", "text": [ "atropine" ], "offsets": [ [ 783, 791 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001285" } ] }, { "id": "23361868_MESH:D002217_12", "type": "Chemical", "text": [ "Carbamylcholine chloride" ], "offsets": [ [ 819, 843 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002217" } ] }, { "id": "23361868_20510_13", "type": "Gene", "text": [ "EAAT3" ], "offsets": [ [ 934, 939 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "20510" } ] }, { "id": "23361868_10090_14", "type": "Species", "text": [ "mice" ], "offsets": [ [ 949, 953 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "23361868_20510_15", "type": "Gene", "text": [ "EAAT3" ], "offsets": [ [ 983, 988 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "20510" } ] }, { "id": "23361868_20510_16", "type": "Gene", "text": [ "EAAT3" ], "offsets": [ [ 1150, 1155 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "20510" } ] }, { "id": "23361868_10090_17", "type": "Species", "text": [ "mice" ], "offsets": [ [ 1165, 1169 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "23361868_MESH:D018698_18", "type": "Chemical", "text": [ "glutamate" ], "offsets": [ [ 1293, 1302 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018698" } ] } ]

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[ { "id": "12371449_title", "type": "title", "text": [ "Homeopathic treatment of chronic headache: a critique." ], "offsets": [ [ 0, 54 ] ] }, { "id": "12371449_abstract", "type": "abstract", "text": [ "The author critically reviews a randomised controlled trial by homeopathy for chronic headache and an observational follow-up study of the same patient cohort. The results showed no difference between homeopathy and placebo. The author believes that these results were a 'false negative' due to inadequate homeopathic treatment, particularly relating to the duration of symptoms and handling of homeopathic aggravations. Guidelines for future studies are proposed." ], "offsets": [ [ 55, 519 ] ] } ]

[ { "id": "12371449_MESH:D006261_0", "type": "Disease", "text": [ "headache" ], "offsets": [ [ 33, 41 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006261" } ] }, { "id": "12371449_MESH:D020773_1", "type": "Disease", "text": [ "homeopathy for chronic headache" ], "offsets": [ [ 118, 149 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020773" } ] }, { "id": "12371449_9606_2", "type": "Species", "text": [ "patient" ], "offsets": [ [ 199, 206 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "26786824_title", "type": "title", "text": [ "Low-molecular-weight heparin for the treatment of acute venous thromboembolism in patients with active cancer." ], "offsets": [ [ 0, 110 ] ] }, { "id": "26786824_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 111, 111 ] ] } ]

[ { "id": "26786824_MESH:D006493_0", "type": "Chemical", "text": [ "heparin" ], "offsets": [ [ 21, 28 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006493" } ] }, { "id": "26786824_MESH:D054556_1", "type": "Disease", "text": [ "venous thromboembolism" ], "offsets": [ [ 56, 78 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054556" } ] }, { "id": "26786824_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 82, 90 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "26786824_MESH:D009369_3", "type": "Disease", "text": [ "cancer" ], "offsets": [ [ 103, 109 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] } ]

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[ { "id": "26880975_title", "type": "title", "text": [ "Residual Dyslipidemia Leads to Unfavorable Outcomes in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention." ], "offsets": [ [ 0, 134 ] ] }, { "id": "26880975_abstract", "type": "abstract", "text": [ "Background. The present study aimed to evaluate the prevalence and prognosis of residual lipid abnormalities in statin-treated acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI). Subjects and Methods. A total of 3,047 ACS patients who underwent PCI and received statin therapy were included. Plasma concentrations of LDL-C, HDL-C, and TG were measured. For the follow-up study, major adverse cardiovascular cerebrovascular events (MACCE; including total death, cardiovascular death, myocardial infarction, and revascularization) were documented. Results. A total of 93.14% of all individuals were followed up for 18.1 months (range, 0-29.3 months). Of all 3,047 patients, those with a suboptimal goal were 67.75%, 85.85%, and 33.64% for LDL-C, HDL-C, and TG levels, respectively. Multiple Cox regression analysis revealed there were significant increases in cumulative MACCE of 41% (HR = 1.41, 95% CI [1.09-1.82], p = 0.008), and revascularization of 48% (HR = 1.48, 95% CI [1.10-1.99], p = 0.01) in low HDL-C patients with ACS after PCI, but not the high TG group at the end of study. Conclusions. Our results showed there is high rate of dyslipidemia in Chinese ACS patients after PCI. Importantly, low HDL-C but not high TG levels are associated with higher MACCE and revascularization rates in ACS patients after PCI." ], "offsets": [ [ 135, 1491 ] ] } ]

[ { "id": "26880975_MESH:D050171_0", "type": "Disease", "text": [ "Dyslipidemia" ], "offsets": [ [ 9, 21 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050171" } ] }, { "id": "26880975_9606_1", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 55, 63 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "26880975_MESH:D054058_2", "type": "Disease", "text": [ "Acute Coronary Syndrome" ], "offsets": [ [ 69, 92 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054058" } ] }, { "id": "26880975_MESH:C562935_3", "type": "Disease", "text": [ "lipid abnormalities" ], "offsets": [ [ 224, 243 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C562935" } ] }, { "id": "26880975_MESH:D054058_4", "type": "Disease", "text": [ "acute coronary syndrome" ], "offsets": [ [ 262, 285 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054058" } ] }, { "id": "26880975_MESH:D054058_5", "type": "Disease", "text": [ "ACS" ], "offsets": [ [ 287, 290 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054058" } ] }, { "id": "26880975_9606_6", "type": "Species", "text": [ "patients" ], "offsets": [ [ 292, 300 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "26880975_MESH:D054058_7", "type": "Disease", "text": [ "ACS" ], "offsets": [ [ 388, 391 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054058" } ] }, { "id": "26880975_9606_8", "type": "Species", "text": [ "patients" ], "offsets": [ [ 392, 400 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "26880975_-_9", "type": "Chemical", "text": [ "LDL-C" ], "offsets": [ [ 487, 492 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "26880975_MESH:D002318_10", "type": "Disease", "text": [ "cardiovascular cerebrovascular" ], "offsets": [ [ 562, 592 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002318" } ] }, { "id": "26880975_MESH:D003643_11", "type": "Disease", "text": [ "death" ], "offsets": [ [ 624, 629 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "26880975_MESH:D002318_12", "type": "Disease", "text": [ "cardiovascular death" ], "offsets": [ [ 631, 651 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002318" } ] }, { "id": "26880975_MESH:D009203_13", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 653, 674 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009203" } ] }, { "id": "26880975_9606_14", "type": "Species", "text": [ "patients" ], "offsets": [ [ 832, 840 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "26880975_-_15", "type": "Chemical", "text": [ "LDL-C" ], "offsets": [ [ 907, 912 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "26880975_MESH:D013866_16", "type": "Chemical", "text": [ "TG" ], "offsets": [ [ 925, 927 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013866" } ] }, { "id": "26880975_9606_17", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1180, 1188 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "26880975_MESH:D054058_18", "type": "Disease", "text": [ "ACS" ], "offsets": [ [ 1194, 1197 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054058" } ] }, { "id": "26880975_MESH:D013866_19", "type": "Chemical", "text": [ "TG" ], "offsets": [ [ 1226, 1228 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013866" } ] }, { "id": "26880975_MESH:D050171_20", "type": "Disease", "text": [ "dyslipidemia" ], "offsets": [ [ 1310, 1322 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D050171" } ] }, { "id": "26880975_MESH:D054058_21", "type": "Disease", "text": [ "ACS" ], "offsets": [ [ 1334, 1337 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054058" } ] }, { "id": "26880975_9606_22", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1338, 1346 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "26880975_MESH:D054058_23", "type": "Disease", "text": [ "ACS" ], "offsets": [ [ 1468, 1471 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D054058" } ] }, { "id": "26880975_9606_24", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1472, 1480 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "17035692_title", "type": "title", "text": [ "Hospital admissions associated with traumatic brain injury in the US Army during peacetime: 1990s trends." ], "offsets": [ [ 0, 105 ] ] }, { "id": "17035692_abstract", "type": "abstract", "text": [ "INTRODUCTION: This paper examines 10-year trends in traumatic brain injury (TBI)-related hospitalization rates for active duty US Army personnel in the 1990s. It does this within the context of various factors, including enhanced injury prevention policies and changed hospital admission practices, that may have affected TBI hospitalization rates. It also compares TBI hospitalization rates in the Army to those from an age-comparable segment of the US civilian population over this time period. METHODS: Crude (unadjusted) incidence rates for all active duty US Army personnel hospitalized with a TBI diagnosis from fiscal years (FY) 1990 to 1999 were calculated. Once the trends were identified, the percentage change in the overall rate, as well as the rates for different TBI severity levels, and in-hospital deaths from FY1990 and FY1999 were analyzed. Changes in age- and gender-specific rates as well as crude rates for cases with and without other injuries and cases treated in military and civilian hospitals were also analyzed. Rate ratios were used to compare aggregated 5-year TBI hospitalization rates in the Army to rates for civilians 17-49 years of age during the following time periods: 1990-1994 and 1995-1999. The rates used in the comparison were adjusted to control for differences in age and gender. RESULTS: The overall incidence of TBI-related hospitalization in the Army decreased 75% from FY1990 to FY1999. The rates for all TBI severity levels decreased, but the rate for mild TBI decreased more than the rates for moderate and severe TBI. The rate of in-hospital deaths from TBI also decreased. Rates decreased similarly for males and females, across all age groups, as well as for cases with and without other injuries. TBI rates decreased for Army personnel treated in military hospitals but changed minimally for Army personnel treated in civilian hospitals. The Army's TBI hospitalization rates were generally higher than civilian rates in the early 1990s but by the late 1990s, most of the Army's rates were lower than or equal to the civilian rates. CONCLUSIONS: The incidence of TBI-related hospitalization in the active duty US Army decreased markedly (75%) during the 1990s. As a result, most of the Army's TBI hospitalization rates were lower than civilian rates by the late 1990s. Effective injury prevention and changes in the Army population were two of the factors that likely contributed to the decrease in rates for all TBI severity levels, while changes in hospital admission practices likely contributed to the disproportionate decrease in the Army's rates for mild TBI." ], "offsets": [ [ 106, 2723 ] ] } ]

[ { "id": "17035692_MESH:D000070642_0", "type": "Disease", "text": [ "traumatic brain injury" ], "offsets": [ [ 36, 58 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_1", "type": "Disease", "text": [ "traumatic brain injury" ], "offsets": [ [ 158, 180 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_2", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 182, 185 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_3", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 428, 431 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_4", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 472, 475 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_5", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 705, 708 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_6", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 883, 886 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D003643_7", "type": "Disease", "text": [ "deaths" ], "offsets": [ [ 920, 926 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "17035692_MESH:D014947_8", "type": "Disease", "text": [ "injuries" ], "offsets": [ [ 1063, 1071 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014947" } ] }, { "id": "17035692_MESH:D000070642_9", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 1196, 1199 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_10", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 1463, 1466 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_11", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 1558, 1561 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_12", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 1611, 1614 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_13", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 1669, 1672 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D003643_14", "type": "Disease", "text": [ "deaths" ], "offsets": [ [ 1698, 1704 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "17035692_MESH:D000070642_15", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 1710, 1713 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D014947_16", "type": "Disease", "text": [ "injuries" ], "offsets": [ [ 1846, 1854 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014947" } ] }, { "id": "17035692_MESH:D000070642_17", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 1856, 1859 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_18", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 2008, 2011 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_19", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 2221, 2224 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_20", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 2351, 2354 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_21", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 2571, 2574 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] }, { "id": "17035692_MESH:D000070642_22", "type": "Disease", "text": [ "TBI" ], "offsets": [ [ 2719, 2722 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000070642" } ] } ]

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[ { "id": "5740806_title", "type": "title", "text": [ "[Statistical study of breech presentation in 160,000 labors during 10 years (1956-1965)]." ], "offsets": [ [ 0, 89 ] ] }, { "id": "5740806_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 90, 90 ] ] } ]

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[ { "id": "17235003_title", "type": "title", "text": [ "The perihepatic space: comprehensive anatomy and CT features of pathologic conditions." ], "offsets": [ [ 0, 86 ] ] }, { "id": "17235003_abstract", "type": "abstract", "text": [ "The liver is covered by visceral peritoneum except at the bare area, bed of the gallbladder, and porta hepatis. The investing peritoneum becomes contiguous with the adjacent structures such as the diaphragmatic peritoneum, lesser omentum, and ligamentum teres. An inflammatory process or tumors involving the perihepatic space are usually affected by intraperitoneal flow dynamics, which depend on the anatomy of the recess as well as gravity and negative subdiaphragmatic pressure. Pathologic conditions that occur in the perihepatic space include abnormal air, fatty masses, conditions producing fluid attenuation at computed tomography (CT), and soft-tissue masses. Enhancement of the hepatic capsule indicates inflammation, as is seen in Fitz-Hugh-Curtis syndrome. The perihepatic ligaments may be invaded by various conditions by means of direct invasion, subperitoneal extension, or extension along the lymphatic vessels. Knowledge of the normal anatomy of the perihepatic space together with the clinical history and characteristic features at CT can assist the radiologist in making the correct diagnosis." ], "offsets": [ [ 87, 1200 ] ] } ]

[ { "id": "17235003_MESH:D009369_0", "type": "Disease", "text": [ "tumors" ], "offsets": [ [ 375, 381 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "17235003_MESH:D007249_1", "type": "Disease", "text": [ "inflammation" ], "offsets": [ [ 801, 813 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007249" } ] }, { "id": "17235003_MESH:C537936_2", "type": "Disease", "text": [ "Fitz-Hugh-Curtis syndrome" ], "offsets": [ [ 829, 854 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C537936" } ] } ]

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[ { "id": "3966454_title", "type": "title", "text": [ "Evaluation of colonic neoplasia by flow cytometry of endoscopic biopsies." ], "offsets": [ [ 0, 73 ] ] }, { "id": "3966454_abstract", "type": "abstract", "text": [ "Colonoscopy is a valuable and frequently used method in the evaluation of colonic neoplasia. Flow cytometry is a technique that can be used to diagnose malignancy. In this study, flow cytometry was used to evaluate colonoscopic biopsies taken from patients with suspected colonic neoplasia. Nineteen colonic biopsies were obtained and evaluated by this technique. Aneuploidy was demonstrated in six patients with carcinoma of the colon. In addition, abnormal DNA histograms were noted in two premalignant conditions (colonic adenoma and inflammatory bowel disease). The results show that flow cytometry can be applied to colonic biopsies and suggest that it may be of use in the diagnosis of malignant and premalignant conditions of the colon." ], "offsets": [ [ 74, 817 ] ] } ]

[ { "id": "3966454_MESH:D003110_0", "type": "Disease", "text": [ "colonic neoplasia" ], "offsets": [ [ 14, 31 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003110" } ] }, { "id": "3966454_MESH:D003110_1", "type": "Disease", "text": [ "colonic neoplasia" ], "offsets": [ [ 148, 165 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003110" } ] }, { "id": "3966454_MESH:D009369_2", "type": "Disease", "text": [ "malignancy" ], "offsets": [ [ 226, 236 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "3966454_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 322, 330 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "3966454_MESH:D003110_4", "type": "Disease", "text": [ "colonic neoplasia" ], "offsets": [ [ 346, 363 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003110" } ] }, { "id": "3966454_MESH:D003110_5", "type": "Disease", "text": [ "colonic" ], "offsets": [ [ 374, 381 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003110" } ] }, { "id": "3966454_MESH:D000782_6", "type": "Disease", "text": [ "Aneuploidy" ], "offsets": [ [ 438, 448 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000782" } ] }, { "id": "3966454_9606_7", "type": "Species", "text": [ "patients" ], "offsets": [ [ 473, 481 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "3966454_MESH:D003110_8", "type": "Disease", "text": [ "carcinoma of the colon" ], "offsets": [ [ 487, 509 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003110" } ] }, { "id": "3966454_MESH:D000236_9", "type": "Disease", "text": [ "colonic adenoma" ], "offsets": [ [ 591, 606 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000236" } ] }, { "id": "3966454_MESH:D015212_10", "type": "Disease", "text": [ "inflammatory bowel disease" ], "offsets": [ [ 611, 637 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D015212" } ] }, { "id": "3966454_MESH:D003110_11", "type": "Disease", "text": [ "colonic" ], "offsets": [ [ 695, 702 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003110" } ] } ]

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[ { "id": "32204303_title", "type": "title", "text": [ "Association between TUG and Anthropometric Values, Vibration Perception Threshold, FHSQ and 15-D in Type 2 Diabetes Mellitus Patients." ], "offsets": [ [ 0, 134 ] ] }, { "id": "32204303_abstract", "type": "abstract", "text": [ "Background: Diabetes Mellitus (DM) is a chronic disease and it is characterized by reduced insulin sensitivity and/or impaired insulin production. It affects approximately 415 million people worldwide and involves a variety of complications. DM has a number of complications, including diabetic neuropathy. All of these complications can have effects on body composition, vibration perception threshold (VPT), foot health and health-related quality of life (HRQoL). Objective: The aim of this study is to determine the correlation between the Timed Up and Go (TUG), VPT, Foot Health Status Questionnaire and 15-D Questionnaire in type 2 diabetes mellitus (T2DM) patients. Methodology: A total of 90 T2DM patients (56 men and 34 women) were evaluated on their body composition, VPT, the foot health status through the FHSQ, the HRQoL was evaluated through the 15-D Questionnaire and the TUG test was performed. Results: Statistically significant associations were found between TUG and lean and fat mass, VPT, the sections \"General Foot Health\" and \"Physical Activity\" in the FHSQ questionnaire, and the 15D total score and its sections \"Mobility\" and \"Depression\". Conclusions: There is a moderate direct correlation between the Timed Up and Go and the fat mass percentage and the vibration perception threshold. Moreover, there is a moderate inverse correlation between Timed Up and Go and fat-free mass, foot health and health-related quality of life in T2DM patients. Therefore, Timed Up and Go can be a tool to assist clinicians in monitoring and managing T2DM patients." ], "offsets": [ [ 135, 1709 ] ] } ]

[ { "id": "32204303_MESH:D003924_0", "type": "Disease", "text": [ "Type 2 Diabetes Mellitus" ], "offsets": [ [ 100, 124 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003924" } ] }, { "id": "32204303_9606_1", "type": "Species", "text": [ "Patients" ], "offsets": [ [ 125, 133 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32204303_MESH:D003920_2", "type": "Disease", "text": [ "Diabetes Mellitus" ], "offsets": [ [ 147, 164 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "32204303_MESH:D003920_3", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 166, 168 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "32204303_MESH:D002908_4", "type": "Disease", "text": [ "chronic disease" ], "offsets": [ [ 175, 190 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002908" } ] }, { "id": "32204303_9606_5", "type": "Species", "text": [ "people" ], "offsets": [ [ 319, 325 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32204303_MESH:D003920_6", "type": "Disease", "text": [ "DM" ], "offsets": [ [ 377, 379 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "32204303_MESH:D003929_7", "type": "Disease", "text": [ "diabetic neuropathy" ], "offsets": [ [ 421, 440 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003929" } ] }, { "id": "32204303_MESH:D003924_8", "type": "Disease", "text": [ "type 2 diabetes mellitus" ], "offsets": [ [ 765, 789 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003924" } ] }, { "id": "32204303_MESH:D003924_9", "type": "Disease", "text": [ "T2DM" ], "offsets": [ [ 791, 795 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003924" } ] }, { "id": "32204303_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 797, 805 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32204303_MESH:D003924_11", "type": "Disease", "text": [ "T2DM" ], "offsets": [ [ 834, 838 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003924" } ] }, { "id": "32204303_9606_12", "type": "Species", "text": [ "patients" ], "offsets": [ [ 839, 847 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32204303_9606_13", "type": "Species", "text": [ "men" ], "offsets": [ [ 852, 855 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32204303_9606_14", "type": "Species", "text": [ "women" ], "offsets": [ [ 863, 868 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32204303_MESH:D000275_15", "type": "Disease", "text": [ "Depression" ], "offsets": [ [ 1287, 1297 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000275" } ] }, { "id": "32204303_MESH:D003924_16", "type": "Disease", "text": [ "T2DM" ], "offsets": [ [ 1591, 1595 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003924" } ] }, { "id": "32204303_9606_17", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1596, 1604 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32204303_MESH:D003924_18", "type": "Disease", "text": [ "T2DM" ], "offsets": [ [ 1695, 1699 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003924" } ] }, { "id": "32204303_9606_19", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1700, 1708 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "5714469_title", "type": "title", "text": [ "[Results of intensive treatment of myocardial infarct with reference to the psychosomatic aspects]." ], "offsets": [ [ 0, 99 ] ] }, { "id": "5714469_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 100, 100 ] ] } ]

[ { "id": "5714469_MESH:D009203_0", "type": "Disease", "text": [ "myocardial infarct" ], "offsets": [ [ 35, 53 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009203" } ] } ]

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[ { "id": "11594527_title", "type": "title", "text": [ "Severe autoimmune thrombocytopenia after allogeneic bone marrow transplantation for aplastic anemia." ], "offsets": [ [ 0, 100 ] ] }, { "id": "11594527_abstract", "type": "abstract", "text": [ "Autoimmune thrombocytopenia (AITP) after bone marrow transplantation (BMT) was suggested to occur by immune dysregulation mainly in association with graft-versus-host disease (GVHD). Here we present a patient who developed severe AITP after BMT. A 40-year-old woman with severe aplastic anemia received a BMT from a partially HLA-matched brother. Despite myeloid and erythroid engraftments, platelet recovery was delayed. All bone marrow cells were 46,XY and were derived from the donor. Grade I acute GVHD involving skin developed from day 34 posttransplantation, but promptly responded to prednisolone in addition to a prophylactic dose of tacrolimus. With the tapering of prednisolone, thrombocytopenia progressed without substantial changes in the white blood cell count, hemoglobin concentration, or reticulocyte count. On day 188, the patient developed chronic GVHD involving skin and liver, which promptly responded to the readministration of prednisolone and increased tacrolimus. However, the patient's platelet count decreased to 9 x 10(9) cells/L on day 222. The platelet-associated immunoglobulin G (PAIgG) values were elevated. Bone marrow examination showed hypercellularity with plentiful megakaryocytes. The number of colony-forming units-megakaryocyte was within the normal range. The elevated PAIgG values and a correlation between thrombocytopenia and the intensity of the immunosuppressive agents strongly suggested a causative role of the autoimmune mechanisms for thrombocytopenia in this patient." ], "offsets": [ [ 101, 1620 ] ] } ]

[ { "id": "11594527_MESH:D016553_0", "type": "Disease", "text": [ "autoimmune thrombocytopenia" ], "offsets": [ [ 7, 34 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016553" } ] }, { "id": "11594527_MESH:D000741_1", "type": "Disease", "text": [ "aplastic anemia" ], "offsets": [ [ 84, 99 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000741" } ] }, { "id": "11594527_MESH:D016553_2", "type": "Disease", "text": [ "Autoimmune thrombocytopenia" ], "offsets": [ [ 101, 128 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016553" } ] }, { "id": "11594527_MESH:D016553_3", "type": "Disease", "text": [ "AITP" ], "offsets": [ [ 130, 134 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016553" } ] }, { "id": "11594527_MESH:D006086_4", "type": "Disease", "text": [ "graft-versus-host disease" ], "offsets": [ [ 250, 275 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006086" } ] }, { "id": "11594527_MESH:D006086_5", "type": "Disease", "text": [ "GVHD" ], "offsets": [ [ 277, 281 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006086" } ] }, { "id": "11594527_9606_6", "type": "Species", "text": [ "patient" ], "offsets": [ [ 302, 309 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11594527_MESH:D016553_7", "type": "Disease", "text": [ "AITP" ], "offsets": [ [ 331, 335 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016553" } ] }, { "id": "11594527_9606_8", "type": "Species", "text": [ "woman" ], "offsets": [ [ 361, 366 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11594527_MESH:D000741_9", "type": "Disease", "text": [ "aplastic anemia" ], "offsets": [ [ 379, 394 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000741" } ] }, { "id": "11594527_MESH:D006086_10", "type": "Disease", "text": [ "GVHD" ], "offsets": [ [ 603, 607 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006086" } ] }, { "id": "11594527_MESH:D011239_11", "type": "Chemical", "text": [ "prednisolone" ], "offsets": [ [ 692, 704 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011239" } ] }, { "id": "11594527_MESH:D016559_12", "type": "Chemical", "text": [ "tacrolimus" ], "offsets": [ [ 743, 753 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016559" } ] }, { "id": "11594527_MESH:D011239_13", "type": "Chemical", "text": [ "prednisolone" ], "offsets": [ [ 776, 788 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011239" } ] }, { "id": "11594527_MESH:D013921_14", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 790, 806 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013921" } ] }, { "id": "11594527_9606_15", "type": "Species", "text": [ "patient" ], "offsets": [ [ 942, 949 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11594527_MESH:D006086_16", "type": "Disease", "text": [ "GVHD" ], "offsets": [ [ 968, 972 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006086" } ] }, { "id": "11594527_MESH:D011239_17", "type": "Chemical", "text": [ "prednisolone" ], "offsets": [ [ 1051, 1063 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D011239" } ] }, { "id": "11594527_MESH:D016559_18", "type": "Chemical", "text": [ "tacrolimus" ], "offsets": [ [ 1078, 1088 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016559" } ] }, { "id": "11594527_9606_19", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1103, 1110 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11594527_MESH:D013921_20", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 1451, 1467 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013921" } ] }, { "id": "11594527_MESH:D013921_21", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 1587, 1603 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013921" } ] }, { "id": "11594527_9606_22", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1612, 1619 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "31428264_title", "type": "title", "text": [ "Learning Abroad: Residents' Narratives of Clinical Experiences From a Global Health Elective." ], "offsets": [ [ 0, 93 ] ] }, { "id": "31428264_abstract", "type": "abstract", "text": [ "Background: While resident participation in global health (GH) rotations has grown, little is known about trainee perceptions of the personal value of these international clinical experiences and their importance to the objectives of GH training. Objective: We sought to better understand the clinical scenarios experienced during international rotations that residents perceived as most meaningful and the frequency of these experiences across scenarios and participating residents. Methods: Using the conceptual framework of Schon's reflection on action, we asked University of Minnesota GH track pediatric and internal medicine-pediatric residents to describe 10 clinical scenarios they found interesting or impactful during their 2016-2017 GH elective. We conducted a qualitative analysis of the deidentified resident narratives and mapped themes to the Accreditation Council for Graduate Medical Education (ACGME) competencies. Results: All eligible residents (n = 13) participated, yielding 129 unique clinical scenarios from 7 countries. We identified 5 thematic groups: (1) addressing challenges in making diagnoses in resource-limited settings; (2) dealing with patient outcomes different from those expected in the United States; (3) encountering and managing diseases in a different clinical context; (4) encountering and managing diseases in a different cultural context; and (5) reflecting on learning and self-growth. Of the 129 unique clinical scenarios, 30% (n = 39) had not been previously experienced by participants. Across the 5 themes, all ACGME core competencies were addressed. Conclusions: Residents identified meaningful scenarios of their GH experiences that are relevant to the educational and clinical objectives of GH training." ], "offsets": [ [ 94, 1850 ] ] } ]

[ { "id": "31428264_8836_0", "type": "Gene", "text": [ "GH" ], "offsets": [ [ 153, 155 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "8836" } ] }, { "id": "31428264_8836_1", "type": "Gene", "text": [ "GH" ], "offsets": [ [ 328, 330 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "8836" } ] }, { "id": "31428264_8836_2", "type": "Gene", "text": [ "GH" ], "offsets": [ [ 684, 686 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "8836" } ] }, { "id": "31428264_8836_3", "type": "Gene", "text": [ "GH" ], "offsets": [ [ 838, 840 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "8836" } ] }, { "id": "31428264_9606_4", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1265, 1272 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "31428264_9606_5", "type": "Species", "text": [ "participants" ], "offsets": [ [ 1616, 1628 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "31428264_-_6", "type": "Chemical", "text": [ "ACGME" ], "offsets": [ [ 1655, 1660 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "31428264_8836_7", "type": "Gene", "text": [ "GH" ], "offsets": [ [ 1759, 1761 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "8836" } ] }, { "id": "31428264_8836_8", "type": "Gene", "text": [ "GH" ], "offsets": [ [ 1838, 1840 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "8836" } ] } ]

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[ { "id": "11421903_title", "type": "title", "text": [ "Duration of the antihistaminic effect after discontinuation of ebastine." ], "offsets": [ [ 0, 72 ] ] }, { "id": "11421903_abstract", "type": "abstract", "text": [ "BACKGROUND: The inhibitory effect of antihistamines on allergen-induced skin reactions can impair the results of allergen skin testing, which are necessary for the diagnosis of atopic diseases. This study was designed to determine the time period required for the inhibitory effect of ebastine on allergen-induced skin reactivity to disappear completely. METHODS: This was a double-blind, placebo-controlled, parallel-group study including 23 out of 27 randomized patients. They received either ebastine 20 mg or placebo once daily for 7 days. At the end of treatment, allergen challenge was performed daily for 7 days. Histamine challenge was performed on day 1 (6 and 24 h) and day 5 after treatment. The wheal and flare surface areas were measured and analyzed. RESULTS: Highly significant inhibition of the wheal and flare response induced by allergen was observed after ebastine treatment on days 1 and 2 as compared with placebo (P < 0.01 for both). The inhibition was reduced, although still significant, by day 3 (P < 0.05). No significant difference was observed by day 4 between the ebastine and the placebo groups. The effects of histamine challenge were significantly reduced in the ebastine compared with the placebo group at day 1 (6 and 24 h), and were similar at day 5 after treatment. CONCLUSION: Our results show that the wheal and flare response to allergen after ebastine discontinuation returns to placebo values after 4 days. Therefore, patients using ebastine need to be antihistamine-free for 4 days before the skin prick test. This is valuable information for the allergologist seeking to diagnose allergen sensitivity." ], "offsets": [ [ 73, 1717 ] ] } ]

[ { "id": "11421903_MESH:C058249_0", "type": "Chemical", "text": [ "ebastine" ], "offsets": [ [ 63, 71 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C058249" } ] }, { "id": "11421903_MESH:C566404_1", "type": "Disease", "text": [ "atopic diseases" ], "offsets": [ [ 250, 265 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C566404" } ] }, { "id": "11421903_MESH:C058249_2", "type": "Chemical", "text": [ "ebastine" ], "offsets": [ [ 358, 366 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C058249" } ] }, { "id": "11421903_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 537, 545 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11421903_MESH:C058249_4", "type": "Chemical", "text": [ "ebastine" ], "offsets": [ [ 568, 576 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C058249" } ] }, { "id": "11421903_MESH:D006632_5", "type": "Chemical", "text": [ "Histamine" ], "offsets": [ [ 693, 702 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006632" } ] }, { "id": "11421903_MESH:C058249_6", "type": "Chemical", "text": [ "ebastine" ], "offsets": [ [ 948, 956 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C058249" } ] }, { "id": "11421903_MESH:C058249_7", "type": "Chemical", "text": [ "ebastine" ], "offsets": [ [ 1166, 1174 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C058249" } ] }, { "id": "11421903_MESH:D006632_8", "type": "Chemical", "text": [ "histamine" ], "offsets": [ [ 1214, 1223 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006632" } ] }, { "id": "11421903_MESH:C058249_9", "type": "Chemical", "text": [ "ebastine" ], "offsets": [ [ 1268, 1276 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C058249" } ] }, { "id": "11421903_MESH:C058249_10", "type": "Chemical", "text": [ "ebastine" ], "offsets": [ [ 1456, 1464 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C058249" } ] }, { "id": "11421903_9606_11", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1532, 1540 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "11421903_MESH:C058249_12", "type": "Chemical", "text": [ "ebastine" ], "offsets": [ [ 1547, 1555 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C058249" } ] } ]

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[ { "id": "2708918_title", "type": "title", "text": [ "An epidemiological model with a delay and a nonlinear incidence rate." ], "offsets": [ [ 0, 69 ] ] }, { "id": "2708918_abstract", "type": "abstract", "text": [ "An epidemiological model with both a time delay in the removed class and a nonlinear incidence rate is analysed to determine the equilibria and their stability. This model is for diseases where individuals are first susceptible, then infected, then removed with temporary immunity and then susceptible again when they lose their immunity. There are multiple equilibria for some parameter values, and, for certain of these, periodic solutions arise by Hopf bifurcation from the large nontrivial equilibrium state." ], "offsets": [ [ 70, 582 ] ] } ]

[ { "id": "2708918_MESH:D007239_0", "type": "Disease", "text": [ "infected" ], "offsets": [ [ 304, 312 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] } ]

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[ { "id": "31904165_title", "type": "title", "text": [ "Ghost Cells for Mechanical Circulatory Support In Vitro Testing: A Novel Large Volume Production." ], "offsets": [ [ 0, 97 ] ] }, { "id": "31904165_abstract", "type": "abstract", "text": [ "The aim of this work is to establish a large volume batch production system to produce sufficient volumes of ghost cells to facilitate hemolysis testing of mechanical circulatory support devices. A volume of more than 405 mL with a hematocrit of at least 28% is required to perform in vitro hemolysis testing of mechanical circulatory support devices according to international standards. The established ghost cell production method performed at the institute is limited to 3.1 mL of concentrated cells, that is, cells with 100% hematocrit, due to predominantly manual process steps. Through semi-automation of the existing method by using the large volume batch production system, productivity is increased 60-fold to 188 mL while almost doubling process efficiency to 23.5%. Time-consuming manual work such as pipetting is now supported by sensor-based process engineering. With the help of the large volume batch production system, the objective of producing large quantities of ghost cells is successfully achieved. Thus, this work lays the foundation for spatially resolved hemolysis evaluation of mechanical circulatory support devices in combination with the small-scale fluorescent hemolysis detection method." ], "offsets": [ [ 98, 1316 ] ] } ]

[ { "id": "31904165_MESH:D006461_0", "type": "Disease", "text": [ "hemolysis" ], "offsets": [ [ 233, 242 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006461" } ] }, { "id": "31904165_MESH:D006461_1", "type": "Disease", "text": [ "hemolysis" ], "offsets": [ [ 389, 398 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006461" } ] }, { "id": "31904165_MESH:D006461_2", "type": "Disease", "text": [ "hemolysis" ], "offsets": [ [ 1178, 1187 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006461" } ] }, { "id": "31904165_MESH:D006461_3", "type": "Disease", "text": [ "hemolysis" ], "offsets": [ [ 1289, 1298 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006461" } ] } ]

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[ { "id": "30332006_title", "type": "title", "text": [ "Outline of an Inquiry on the Pathology of Consumptive Diseases: Part II." ], "offsets": [ [ 0, 72 ] ] }, { "id": "30332006_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 73, 73 ] ] } ]

[ { "id": "30332006_MESH:D014397_0", "type": "Disease", "text": [ "Consumptive Diseases" ], "offsets": [ [ 42, 62 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014397" } ] } ]

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[ { "id": "7783295_title", "type": "title", "text": [ "Medical devices: significant vs nonsignificant risk." ], "offsets": [ [ 0, 52 ] ] }, { "id": "7783295_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 53, 53 ] ] } ]

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[ { "id": "29398270_title", "type": "title", "text": [ "Composition, production rate and characterization of Greek dental solid waste." ], "offsets": [ [ 0, 78 ] ] }, { "id": "29398270_abstract", "type": "abstract", "text": [ "The overall objective of this work is to determine the composition, characterization and production rate of Greek dental solid waste (DSW). This information is important to design and cost management systems for DSW, for safety and health considerations and for assessing environmental impact. A total of 141 kg of DSW produced by a total of 2542 patients in 20 dental practices from Xanthi, Greece was collected, manually separated and weighed over a period of four working weeks. The waste was separated in 19 sub fractions, which were classified in 2 major categories, according to Greek regulations: Domestic-type waste comprising 8% and hazardous waste comprising 92% by weight of total DSW. The latter was further classified in infectious waste, toxic waste and mixed type waste (infectious and toxic together), accounting for 88.5%, 3.5% and 0.03% of total DSW by weight, respectively. The overall unit production rates (mean +- standard error of the mean) were 381 +- 15 g/practice/d and 53.3 +- 1.4 g/patient/d for total DSW, 337 +- 14 g/practice/d and 46.6 +- 1.2 g/patient/d for total infectious DSW, 13.4 +- 0.7 g/practice/d and 2.1 +- 0.1 g/patient/d for total toxic DSW and 30.4 +- 2.5 g/practice/d and 4.6 +- 0.4 g/patient/d for domestic-type waste. Daily DSW production was correlated with daily number of patients and regression correlations were produced. DSW was subject to laboratory characterization in terms of bulk density, calorific value, moisture, ash and volatile solids content. Measured calorific values were compared to predictions from empirical models." ], "offsets": [ [ 79, 1663 ] ] } ]

[ { "id": "29398270_9606_0", "type": "Species", "text": [ "patients" ], "offsets": [ [ 426, 434 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29398270_9606_1", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1089, 1096 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29398270_9606_2", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1155, 1162 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29398270_9606_3", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1233, 1240 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29398270_9606_4", "type": "Species", "text": [ "patient" ], "offsets": [ [ 1309, 1316 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "29398270_9606_5", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1401, 1409 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "2533654_title", "type": "title", "text": [ "Quantitative ultrasonography." ], "offsets": [ [ 0, 29 ] ] }, { "id": "2533654_abstract", "type": "abstract", "text": [ "A perspective on quantitative techniques in diagnostic ultrasound is presented. The method involves the use of multiple tissue characterization features, pattern recognition methods, and imaging techniques to extract diagnostic information beyond that available with conventional imaging techniques. The information that each acoustic property and characterization feature reveals about physical properties of the tissues is discussed, and examples of clinical and laboratory data are summarized. The emphasis is on features that describe the composition, microscopic structure, and flow characteristics of normal and diseased soft tissues." ], "offsets": [ [ 30, 670 ] ] } ]

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[ { "id": "26395168_title", "type": "title", "text": [ "UV, Blue, Green, Yellow, Red, and Small: Newest Developments on Eu(2+)-Doped Nanophosphors." ], "offsets": [ [ 0, 91 ] ] }, { "id": "26395168_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 92, 92 ] ] } ]

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[ { "id": "25337202_title", "type": "title", "text": [ "Heparanase promotes human gastric cancer cells migration and invasion by increasing Src and p38 phosphorylation expression." ], "offsets": [ [ 0, 123 ] ] }, { "id": "25337202_abstract", "type": "abstract", "text": [ "Gastric cancer is one of the most common cancers and it remains difficult to cure, primarily because most cancer stem like cells possess higher capability of invasion and metastasis. Heparanase acts as a master regulator of the aggressive tumor phenotype in part by enhancing expression of proteins and activating signaling molecules. There were less associated with heparanase of molecular biology mechanism in human gastric cancer. We first evaluated the endogenous expression of heparanase in human gastric cancer cell lines and found Heparanase expression higher in SGC-7901 than MGC-803. Using the technology of RNAi in SGC-7901 cells down regulated heparanase gene, and reduced SGC-7901 cells migration and invasion. On the other hand, recombinant heparanase protein added in MGC-803 cells enhanced MGC-803 cell migration and invasion. The elevated cell migration and invasion were impaired by treatment of Src inhibitor pp2 or p38 inhibitor SB 203580. We further found that Stable knockdown of heparanase in SGC-7901 cells decreased phosphorylation of Src and p38. The phosphorylation of p38 was inhibited in response to pp2 treatment while the addition of SB 203580 to SGC-7901 cells did not change phosphorylation of Src. These data suggest that heparanase facilitates invasion and migration of human gastric cancer cells probably through elevating phosphorylation of Src and p38." ], "offsets": [ [ 124, 1513 ] ] } ]

[ { "id": "25337202_10855_0", "type": "Gene", "text": [ "Heparanase" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_9606_1", "type": "Species", "text": [ "human" ], "offsets": [ [ 20, 25 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25337202_MESH:D013274_2", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 26, 40 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "25337202_6714_3", "type": "Gene", "text": [ "Src" ], "offsets": [ [ 84, 87 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "6714" } ] }, { "id": "25337202_MESH:D013274_4", "type": "Disease", "text": [ "Gastric cancer" ], "offsets": [ [ 124, 138 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "25337202_MESH:D009369_5", "type": "Disease", "text": [ "cancers" ], "offsets": [ [ 165, 172 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "25337202_MESH:D009369_6", "type": "Disease", "text": [ "cancer" ], "offsets": [ [ 230, 236 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "25337202_10855_7", "type": "Gene", "text": [ "Heparanase" ], "offsets": [ [ 307, 317 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_MESH:D001523_8", "type": "Disease", "text": [ "aggressive tumor" ], "offsets": [ [ 352, 368 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001523" } ] }, { "id": "25337202_10855_9", "type": "Gene", "text": [ "heparanase" ], "offsets": [ [ 491, 501 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_9606_10", "type": "Species", "text": [ "human" ], "offsets": [ [ 536, 541 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25337202_MESH:D013274_11", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 542, 556 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "25337202_10855_12", "type": "Gene", "text": [ "heparanase" ], "offsets": [ [ 606, 616 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_9606_13", "type": "Species", "text": [ "human" ], "offsets": [ [ 620, 625 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25337202_MESH:D013274_14", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 626, 640 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "25337202_10855_15", "type": "Gene", "text": [ "Heparanase" ], "offsets": [ [ 662, 672 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_CVCL_0520;NCBITaxID:9606_16", "type": "CellLine", "text": [ "SGC-7901" ], "offsets": [ [ 694, 702 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_0520;NCBITaxID:9606" } ] }, { "id": "25337202_CVCL_5334;NCBITaxID:9606_17", "type": "CellLine", "text": [ "MGC-803" ], "offsets": [ [ 708, 715 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_5334;NCBITaxID:9606" } ] }, { "id": "25337202_CVCL_0520;NCBITaxID:9606_18", "type": "CellLine", "text": [ "SGC-7901" ], "offsets": [ [ 749, 757 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_0520;NCBITaxID:9606" } ] }, { "id": "25337202_10855_19", "type": "Gene", "text": [ "heparanase" ], "offsets": [ [ 779, 789 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_CVCL_0520;NCBITaxID:9606_20", "type": "CellLine", "text": [ "SGC-7901" ], "offsets": [ [ 808, 816 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_0520;NCBITaxID:9606" } ] }, { "id": "25337202_10855_21", "type": "Gene", "text": [ "heparanase" ], "offsets": [ [ 878, 888 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_CVCL_5334;NCBITaxID:9606_22", "type": "CellLine", "text": [ "MGC-803" ], "offsets": [ [ 906, 913 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_5334;NCBITaxID:9606" } ] }, { "id": "25337202_CVCL_5334;NCBITaxID:9606_23", "type": "CellLine", "text": [ "MGC-803" ], "offsets": [ [ 929, 936 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_5334;NCBITaxID:9606" } ] }, { "id": "25337202_6714_24", "type": "Gene", "text": [ "Src" ], "offsets": [ [ 1037, 1040 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "6714" } ] }, { "id": "25337202_4888_25", "type": "Gene", "text": [ "pp2" ], "offsets": [ [ 1051, 1054 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "4888" } ] }, { "id": "25337202_MESH:C093642_26", "type": "Chemical", "text": [ "SB 203580" ], "offsets": [ [ 1072, 1081 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C093642" } ] }, { "id": "25337202_10855_27", "type": "Gene", "text": [ "heparanase" ], "offsets": [ [ 1125, 1135 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_CVCL_0520;NCBITaxID:9606_28", "type": "CellLine", "text": [ "SGC-7901" ], "offsets": [ [ 1139, 1147 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_0520;NCBITaxID:9606" } ] }, { "id": "25337202_6714_29", "type": "Gene", "text": [ "Src" ], "offsets": [ [ 1183, 1186 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "6714" } ] }, { "id": "25337202_4888_30", "type": "Gene", "text": [ "pp2" ], "offsets": [ [ 1252, 1255 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "4888" } ] }, { "id": "25337202_MESH:C093642_31", "type": "Chemical", "text": [ "SB 203580" ], "offsets": [ [ 1288, 1297 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C093642" } ] }, { "id": "25337202_CVCL_0520;NCBITaxID:9606_32", "type": "CellLine", "text": [ "SGC-7901" ], "offsets": [ [ 1301, 1309 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "CVCL_0520;NCBITaxID:9606" } ] }, { "id": "25337202_6714_33", "type": "Gene", "text": [ "Src" ], "offsets": [ [ 1350, 1353 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "6714" } ] }, { "id": "25337202_10855_34", "type": "Gene", "text": [ "heparanase" ], "offsets": [ [ 1379, 1389 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "10855" } ] }, { "id": "25337202_9606_35", "type": "Species", "text": [ "human" ], "offsets": [ [ 1428, 1433 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "25337202_MESH:D013274_36", "type": "Disease", "text": [ "gastric cancer" ], "offsets": [ [ 1434, 1448 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013274" } ] }, { "id": "25337202_6714_37", "type": "Gene", "text": [ "Src" ], "offsets": [ [ 1501, 1504 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "6714" } ] } ]

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[ { "id": "16092801_title", "type": "title", "text": [ "MindBodySpirit Medicine." ], "offsets": [ [ 0, 24 ] ] }, { "id": "16092801_abstract", "type": "abstract", "text": [ "OBJECTIVES: To present an overview of MindBodySpirit medicine including discussions of the efficacy of select self-care approaches. DATA SOURCES: Research and clinical articles on select complementary interventions. The model developed by the Center for Mind Body Medicine. CONCLUSION: Good information, self-care skills, and a supportive environment can assist an individual to achieve a higher level of physical, emotional, and spiritual wellness while navigating the cancer experience. IMPLICATIONS FOR NURSING PRACTICE: Increasing numbers of patients with cancer are becoming active in their health care and are choosing complementary approaches. There is an increasing body of literature supporting these interventions in improving quality of life. Nurses can acquire information to help patients navigate the expanding arena of complementary practices. \"What Else Can I Do?\" \"What Else Can I Do?\"" ], "offsets": [ [ 25, 927 ] ] } ]

[ { "id": "16092801_MESH:D009369_0", "type": "Disease", "text": [ "cancer" ], "offsets": [ [ 495, 501 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "16092801_9606_1", "type": "Species", "text": [ "patients" ], "offsets": [ [ 571, 579 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "16092801_MESH:D009369_2", "type": "Disease", "text": [ "cancer" ], "offsets": [ [ 585, 591 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "16092801_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 818, 826 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "12741637_title", "type": "title", "text": [ "Soxhlet extraction of acrylamide from potato chips." ], "offsets": [ [ 0, 51 ] ] }, { "id": "12741637_abstract", "type": "abstract", "text": [ "The problem of complete extraction of acrylamide from potato chips was investigated. A method was developed based on the Soxhlet extraction technique. A defatted sample was extracted continuously with methanol, for 10 days, in a Soxhlet extractor. After about 7 days, a constant concentration of acrylamide was reached. This indicates that all the acrylamide that could be removed from the sample had been extracted. Acrylamide was identified in the extract using GC-MS and scan mode. Total concentration was 14500 microg kg(-1) using GC-FID and standard additions. Complementary determinations, using an external standard (GC-FID and GC-MS) and an internal standard (GC-FID), showed results within +/- 5%. A previously published study, using a static extraction method and GC-MS and LC-MS-MS, showed concentrations of 2287 and 1993 microg kg(-1), respectively. The results are discussed in relation to a recent model and analogous experiments. The extracted amount of acrylamide is affected by several parameters: solvent properties, solvent volume, extraction time, temperature, particle size, and the microstructure of the sample." ], "offsets": [ [ 52, 1185 ] ] } ]

[ { "id": "12741637_MESH:D020106_0", "type": "Chemical", "text": [ "acrylamide" ], "offsets": [ [ 22, 32 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020106" } ] }, { "id": "12741637_4113_1", "type": "Species", "text": [ "potato" ], "offsets": [ [ 38, 44 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "4113" } ] }, { "id": "12741637_MESH:D020106_2", "type": "Chemical", "text": [ "acrylamide" ], "offsets": [ [ 90, 100 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020106" } ] }, { "id": "12741637_4113_3", "type": "Species", "text": [ "potato" ], "offsets": [ [ 106, 112 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "4113" } ] }, { "id": "12741637_MESH:D000432_4", "type": "Chemical", "text": [ "methanol" ], "offsets": [ [ 253, 261 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000432" } ] }, { "id": "12741637_MESH:D020106_5", "type": "Chemical", "text": [ "acrylamide" ], "offsets": [ [ 348, 358 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020106" } ] }, { "id": "12741637_MESH:D020106_6", "type": "Chemical", "text": [ "acrylamide" ], "offsets": [ [ 400, 410 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020106" } ] }, { "id": "12741637_MESH:D020106_7", "type": "Chemical", "text": [ "Acrylamide" ], "offsets": [ [ 469, 479 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020106" } ] }, { "id": "12741637_MESH:D020106_8", "type": "Chemical", "text": [ "acrylamide" ], "offsets": [ [ 1021, 1031 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020106" } ] } ]

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[ { "id": "32314890_title", "type": "title", "text": [ "[Palatal fistula rate after Huaxi Sommerlad-Furlow palatoplasty]." ], "offsets": [ [ 0, 65 ] ] }, { "id": "32314890_abstract", "type": "abstract", "text": [ "OBJECTIVE: This study aimed to determine the palatal fistula rate, explore the influencing factors of Huaxi Sommerlad-Furlow (SF) palatoplasty. METHODS: A retrospective review of 385 consecutive cleft-palate cases was performed to determine the incidence of postoperative fistula and assess the possible contributing factors, such as sex, weight, age, cleft type, operator skills, preoperative white blood cell, preventive antibiotic use, and postoperative temperature. RESULTS: Fistulas occurred in 15/385 patients (3.9%). Among them, 1 fistula was located at the junction of the hard and soft palates, 12 fistulas in hard palate, and 2 fistulas in alveolar near the hard palate. No evidence suggested that sex, weight, age, preoperative white blood cell, preventive antibiotic use, and postoperative temperature are associated with fistula formation. The incidences of cleft palate fistulas as encountered by senior professors (3.03%) and associate senior professors (2.23%) were significantly lower than those by attending doctors (14.29%, P<0.05). The incidences of cleft palate fistulas in bilateral completely cleft palate cases (20.6%) were significantly higher than those in hard and soft (3.6%) and unilateral cleft palate cases (2.6%, P< : 0.05). CONCLUSIONS: Huaxi SF palatoplasty can avoid the inhibited maxillary growth without requiring lateral relaxing incision, which poses an acceptable risk of fistula formation. The palatal fistula rate is not related to the sex, weight, age of operation, prophylactic use of antibiotics before operation, infection before operation, temperature after operation and other factors. The occurrence of the fistula is related mainly to cleft type and experience level of the surgeon." ], "offsets": [ [ 66, 1798 ] ] } ]

[ { "id": "32314890_MESH:D005402_0", "type": "Disease", "text": [ "Palatal fistula" ], "offsets": [ [ 1, 16 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] }, { "id": "32314890_MESH:D005402_1", "type": "Disease", "text": [ "palatal fistula" ], "offsets": [ [ 111, 126 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] }, { "id": "32314890_MESH:D002972_2", "type": "Disease", "text": [ "cleft-palate" ], "offsets": [ [ 261, 273 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002972" } ] }, { "id": "32314890_MESH:D010149_3", "type": "Disease", "text": [ "postoperative fistula" ], "offsets": [ [ 324, 345 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010149" } ] }, { "id": "32314890_9606_4", "type": "Species", "text": [ "patients" ], "offsets": [ [ 573, 581 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "32314890_MESH:D005402_5", "type": "Disease", "text": [ "fistula" ], "offsets": [ [ 604, 611 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] }, { "id": "32314890_MESH:D005402_6", "type": "Disease", "text": [ "fistulas" ], "offsets": [ [ 673, 681 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] }, { "id": "32314890_MESH:D018804_7", "type": "Disease", "text": [ "hard palate" ], "offsets": [ [ 685, 696 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018804" } ] }, { "id": "32314890_MESH:D005402_8", "type": "Disease", "text": [ "fistulas" ], "offsets": [ [ 704, 712 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] }, { "id": "32314890_MESH:D018804_9", "type": "Disease", "text": [ "hard palate" ], "offsets": [ [ 734, 745 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D018804" } ] }, { "id": "32314890_MESH:D005402_10", "type": "Disease", "text": [ "fistula" ], "offsets": [ [ 900, 907 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] }, { "id": "32314890_MESH:D002972_11", "type": "Disease", "text": [ "cleft palate fistulas" ], "offsets": [ [ 937, 958 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002972" } ] }, { "id": "32314890_MESH:D002972_12", "type": "Disease", "text": [ "cleft palate fistulas in bilateral completely cleft palate" ], "offsets": [ [ 1136, 1194 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002972" } ] }, { "id": "32314890_MESH:D002972_13", "type": "Disease", "text": [ "cleft palate" ], "offsets": [ [ 1285, 1297 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002972" } ] }, { "id": "32314890_MESH:D005402_14", "type": "Disease", "text": [ "fistula" ], "offsets": [ [ 1478, 1485 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] }, { "id": "32314890_MESH:D005402_15", "type": "Disease", "text": [ "palatal fistula" ], "offsets": [ [ 1501, 1516 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] }, { "id": "32314890_MESH:D007239_16", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 1625, 1634 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "32314890_MESH:D005402_17", "type": "Disease", "text": [ "fistula" ], "offsets": [ [ 1722, 1729 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005402" } ] } ]

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[ { "id": "11168592_title", "type": "title", "text": [ "Roles of partly unfolded conformations in macromolecular self-assembly." ], "offsets": [ [ 0, 71 ] ] }, { "id": "11168592_abstract", "type": "abstract", "text": [ "From genes to cells there are many steps of hierarchical increments in building up complex frameworks that provide intricate networks of macromolecular interactions, through which cellular activities such as gene expression, signal processing, energy transduction and material conversion are dynamically organized and regulated. The self-assembly of macromolecules into large complexes is one such important step, but this process is by no means a simple aggregation of macromolecules with predefined, rigid complementary structures. In many cases the component molecules undergo either domain rearrangements or folding of disordered portions, which occurs only following binding to their correct partners. The partial disorder is used in some cases to prevent spontaneous assembly at inappropriate times or locations. It is also often used for finely tuning the equilibrium and activation energy of reversible binding. In other cases, such as protein translocation across membranes, an unfolded terminus appears to be the prerequisite for the process as an initiation signal, as well as the physical necessity to be taken into narrow channels. Self-assembly processes of viruses and bacterial flagella are typical examples where the induced folding of disordered chains plays a key role in regulating the addition of new components to a growing assembly. Various aspects of mechanistic roles of natively unfolded conformations of proteins are overviewed and discussed in this short review." ], "offsets": [ [ 72, 1562 ] ] } ]

[ { "id": "11168592_MESH:D016920_0", "type": "Disease", "text": [ "bacterial flagella" ], "offsets": [ [ 1256, 1274 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D016920" } ] } ]

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[ { "id": "27506452_title", "type": "title", "text": [ "Adaptive Immune Response Impairs the Efficacy of Autologous Transplantation of Engineered Stem Cells in Dystrophic Dogs." ], "offsets": [ [ 0, 120 ] ] }, { "id": "27506452_abstract", "type": "abstract", "text": [ "Duchenne muscular dystrophy is the most common genetic muscular dystrophy. It is caused by mutations in the dystrophin gene, leading to absence of muscular dystrophin and to progressive degeneration of skeletal muscle. We have demonstrated that the exon skipping method safely and efficiently brings to the expression of a functional dystrophin in dystrophic CD133+ cells injected scid/mdx mice. Golden Retriever muscular dystrophic (GRMD) dogs represent the best preclinical model of Duchenne muscular dystrophy, mimicking the human pathology in genotypic and phenotypic aspects. Here, we assess the capacity of intra-arterial delivered autologous engineered canine CD133+ cells of restoring dystrophin expression in Golden Retriever muscular dystrophy. This is the first demonstration of five-year follow up study, showing initial clinical amelioration followed by stabilization in mild and severe affected Golden Retriever muscular dystrophy dogs. The occurrence of T-cell response in three Golden Retriever muscular dystrophy dogs, consistent with a memory response boosted by the exon skipped-dystrophin protein, suggests an adaptive immune response against dystrophin." ], "offsets": [ [ 121, 1295 ] ] } ]

[ { "id": "27506452_9615_0", "type": "Species", "text": [ "Dogs" ], "offsets": [ [ 115, 119 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] }, { "id": "27506452_MESH:D020388_1", "type": "Disease", "text": [ "Duchenne muscular dystrophy" ], "offsets": [ [ 121, 148 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020388" } ] }, { "id": "27506452_MESH:D009136_2", "type": "Disease", "text": [ "muscular dystrophy" ], "offsets": [ [ 176, 194 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009136" } ] }, { "id": "27506452_606758_3", "type": "Gene", "text": [ "dystrophin" ], "offsets": [ [ 229, 239 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "606758" } ] }, { "id": "27506452_606758_4", "type": "Gene", "text": [ "dystrophin" ], "offsets": [ [ 277, 287 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "606758" } ] }, { "id": "27506452_MESH:D005207_5", "type": "Disease", "text": [ "degeneration of skeletal muscle" ], "offsets": [ [ 307, 338 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005207" } ] }, { "id": "27506452_13405_6", "type": "Gene", "text": [ "dystrophin" ], "offsets": [ [ 455, 465 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "13405" } ] }, { "id": "27506452_19126_7", "type": "Gene", "text": [ "CD133" ], "offsets": [ [ 480, 485 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "19126" } ] }, { "id": "27506452_10090_8", "type": "Species", "text": [ "mice" ], "offsets": [ [ 511, 515 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "27506452_MESH:D009136_9", "type": "Disease", "text": [ "muscular dystrophic" ], "offsets": [ [ 534, 553 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009136" } ] }, { "id": "27506452_9615_10", "type": "Species", "text": [ "dogs" ], "offsets": [ [ 561, 565 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] }, { "id": "27506452_MESH:D020388_11", "type": "Disease", "text": [ "Duchenne muscular dystrophy" ], "offsets": [ [ 606, 633 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020388" } ] }, { "id": "27506452_9606_12", "type": "Species", "text": [ "human" ], "offsets": [ [ 649, 654 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "27506452_9615_13", "type": "Species", "text": [ "canine" ], "offsets": [ [ 781, 787 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] }, { "id": "27506452_19126_14", "type": "Gene", "text": [ "CD133" ], "offsets": [ [ 788, 793 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "19126" } ] }, { "id": "27506452_606758_15", "type": "Gene", "text": [ "dystrophin" ], "offsets": [ [ 814, 824 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "606758" } ] }, { "id": "27506452_MESH:D009136_16", "type": "Disease", "text": [ "muscular dystrophy" ], "offsets": [ [ 856, 874 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009136" } ] }, { "id": "27506452_MESH:D009136_17", "type": "Disease", "text": [ "muscular dystrophy" ], "offsets": [ [ 1047, 1065 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009136" } ] }, { "id": "27506452_9615_18", "type": "Species", "text": [ "dogs" ], "offsets": [ [ 1066, 1070 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] }, { "id": "27506452_T cell_19", "type": "CellLine", "text": [ "T-cell" ], "offsets": [ [ 1090, 1096 ] ], "normalized": [ { "db_name": "cellosaurus", "db_id": "T cell" } ] }, { "id": "27506452_MESH:D009136_20", "type": "Disease", "text": [ "muscular dystrophy" ], "offsets": [ [ 1132, 1150 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009136" } ] }, { "id": "27506452_9615_21", "type": "Species", "text": [ "dogs" ], "offsets": [ [ 1151, 1155 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9615" } ] }, { "id": "27506452_606758_22", "type": "Gene", "text": [ "dystrophin" ], "offsets": [ [ 1219, 1229 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "606758" } ] }, { "id": "27506452_606758_23", "type": "Gene", "text": [ "dystrophin" ], "offsets": [ [ 1284, 1294 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "606758" } ] } ]

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[ { "id": "1589149_title", "type": "title", "text": [ "Anomalous effect of mazindol on dopamine uptake as measured by in vivo voltammetry and microdialysis." ], "offsets": [ [ 0, 101 ] ] }, { "id": "1589149_abstract", "type": "abstract", "text": [ "The effect of mazindol on the dopamine (DA) uptake system in the rat striatum was studied by in vivo voltammetry and microdialysis. An increase in the maximal uptake rate was observed by voltammetry 30 min after i.p. administration of 1, 5, 10, 15, and 20 mg/kg doses but not after a dose of 25 mg/kg, while stimulated release was enhanced at all doses. The increased maximal uptake is in contrast to increased levels of extracellular DA observed with microdialysis following mazindol administration. This divergence of action is anomalous in the context of current understanding of the DA uptake system." ], "offsets": [ [ 102, 706 ] ] } ]

[ { "id": "1589149_MESH:D008454_0", "type": "Chemical", "text": [ "mazindol" ], "offsets": [ [ 20, 28 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008454" } ] }, { "id": "1589149_MESH:D004298_1", "type": "Chemical", "text": [ "dopamine" ], "offsets": [ [ 32, 40 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004298" } ] }, { "id": "1589149_MESH:D008454_2", "type": "Chemical", "text": [ "mazindol" ], "offsets": [ [ 116, 124 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008454" } ] }, { "id": "1589149_MESH:D004298_3", "type": "Chemical", "text": [ "dopamine" ], "offsets": [ [ 132, 140 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004298" } ] }, { "id": "1589149_MESH:D004298_4", "type": "Chemical", "text": [ "DA" ], "offsets": [ [ 142, 144 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004298" } ] }, { "id": "1589149_10116_5", "type": "Species", "text": [ "rat" ], "offsets": [ [ 167, 170 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "1589149_MESH:D004298_6", "type": "Chemical", "text": [ "DA" ], "offsets": [ [ 537, 539 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004298" } ] }, { "id": "1589149_MESH:D008454_7", "type": "Chemical", "text": [ "mazindol" ], "offsets": [ [ 578, 586 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008454" } ] }, { "id": "1589149_MESH:D004298_8", "type": "Chemical", "text": [ "DA" ], "offsets": [ [ 689, 691 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004298" } ] } ]

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[ { "id": "35449717_title", "type": "title", "text": [ "Posttransplantation Diabetes Mellitus Among Solid Organ Recipients in a Danish Cohort." ], "offsets": [ [ 0, 86 ] ] }, { "id": "35449717_abstract", "type": "abstract", "text": [ "Post-transplant diabetes mellitus (PTDM) is associated with a higher risk of adverse outcomes. We aimed to describe the proportion of patients with diabetes prior to solid organ transplantation (SOT) and post-transplant diabetes mellitus (PTDM) in three time periods (early-likely PTDM: 0-45 days; 46-365 days and >365 days) post-transplant and to estimate possible risk factors associated with PTDM in each time-period. Additionally, we compared the risk of death and causes of death in patients with diabetes prior to transplant, PTDM, and non-diabetes patients. A total of 959 SOT recipients (heart, lung, liver, and kidney) transplanted at University Hospital of Copenhagen between 2010 and 2015 were included. The highest PTDM incidence was observed at 46-365 days after transplant in all SOT recipients. Age and the Charlson Comorbidity Index (CCI Score) in all time periods were the two most important risk factors for PTDM. Compared to non-diabetes patients, SOT recipients with pre-transplant diabetes and PTDM patients had a higher risk of all-cause mortality death (aHR: 1.77, 95% CI: 1.16-2.69 and aHR: 1.89, 95% CI: 1.17-3.06 respectively). Pre-transplant diabetes and PTDM patients had a higher risk of death due to cardiovascular diseases and cancer, respectively, when compared to non-diabetes patients." ], "offsets": [ [ 87, 1406 ] ] } ]

[ { "id": "35449717_MESH:D003920_0", "type": "Disease", "text": [ "Diabetes Mellitus" ], "offsets": [ [ 20, 37 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_MESH:D003920_1", "type": "Disease", "text": [ "diabetes mellitus" ], "offsets": [ [ 103, 120 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 221, 229 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35449717_MESH:D003920_3", "type": "Disease", "text": [ "diabetes" ], "offsets": [ [ 235, 243 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_MESH:D003920_4", "type": "Disease", "text": [ "diabetes mellitus" ], "offsets": [ [ 307, 324 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_MESH:D003643_5", "type": "Disease", "text": [ "death" ], "offsets": [ [ 546, 551 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "35449717_MESH:D003643_6", "type": "Disease", "text": [ "death" ], "offsets": [ [ 566, 571 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "35449717_9606_7", "type": "Species", "text": [ "patients" ], "offsets": [ [ 575, 583 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35449717_MESH:D003920_8", "type": "Disease", "text": [ "diabetes" ], "offsets": [ [ 589, 597 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_MESH:D003920_9", "type": "Disease", "text": [ "non-diabetes" ], "offsets": [ [ 629, 641 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 642, 650 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35449717_MESH:D003920_11", "type": "Disease", "text": [ "diabetes" ], "offsets": [ [ 1035, 1043 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_9606_12", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1044, 1052 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35449717_MESH:D003920_13", "type": "Disease", "text": [ "diabetes" ], "offsets": [ [ 1089, 1097 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_9606_14", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1107, 1115 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35449717_MESH:D003643_15", "type": "Disease", "text": [ "death" ], "offsets": [ [ 1157, 1162 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "35449717_MESH:D003920_16", "type": "Disease", "text": [ "diabetes" ], "offsets": [ [ 1256, 1264 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_9606_17", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1274, 1282 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "35449717_MESH:D003643_18", "type": "Disease", "text": [ "death" ], "offsets": [ [ 1304, 1309 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003643" } ] }, { "id": "35449717_MESH:D002318_19", "type": "Disease", "text": [ "cardiovascular diseases" ], "offsets": [ [ 1317, 1340 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002318" } ] }, { "id": "35449717_MESH:D009369_20", "type": "Disease", "text": [ "cancer" ], "offsets": [ [ 1345, 1351 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "35449717_MESH:D003920_21", "type": "Disease", "text": [ "diabetes" ], "offsets": [ [ 1388, 1396 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003920" } ] }, { "id": "35449717_9606_22", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1397, 1405 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "28677083_title", "type": "title", "text": [ "Statistical optimization of production conditions of beta-glucosidase from Bacillus stratosphericus strain SG9." ], "offsets": [ [ 0, 111 ] ] }, { "id": "28677083_abstract", "type": "abstract", "text": [ "The present study illustrates the optimization and characterization of beta-glucosidase from a bacterial isolate, strain SG9. Sixty-eight different variables were first screened by one factor at a time method. The screened variable optimization was then performed by Plackett-Burman design followed by Box-Behnken response surface methodology. Thirty-one variables were screened, of which five variables were found to be significant. Box-Behnken design was then performed using the most significant variables, viz., esculin, K2HPO4 and MgSO4. The maximum enzyme activity was observed with an optimal medium composition of esculin (1.9 g/L), K2HPO4 (0. 5 g/L) and MgSO4 (0.3 g/L) with a predicted value of 3392.01 IU. The maximum beta-glucosidase production achieved was 3340 IU. The bacterial strain was identified by 16S rRNA gene sequence and biochemical characterization. The strain was identified as Bacillus stratosphericus and is a first report of its kind." ], "offsets": [ [ 112, 1075 ] ] } ]

[ { "id": "28677083_293386_0", "type": "Species", "text": [ "Bacillus stratosphericus" ], "offsets": [ [ 75, 99 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "293386" } ] }, { "id": "28677083_MESH:D004929_1", "type": "Chemical", "text": [ "esculin" ], "offsets": [ [ 628, 635 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004929" } ] }, { "id": "28677083_MESH:C013216_2", "type": "Chemical", "text": [ "K2HPO4" ], "offsets": [ [ 637, 643 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C013216" } ] }, { "id": "28677083_MESH:D008278_3", "type": "Chemical", "text": [ "MgSO4" ], "offsets": [ [ 648, 653 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008278" } ] }, { "id": "28677083_MESH:D004929_4", "type": "Chemical", "text": [ "esculin" ], "offsets": [ [ 734, 741 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004929" } ] }, { "id": "28677083_MESH:C013216_5", "type": "Chemical", "text": [ "K2HPO4" ], "offsets": [ [ 753, 759 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C013216" } ] }, { "id": "28677083_MESH:D008278_6", "type": "Chemical", "text": [ "MgSO4" ], "offsets": [ [ 775, 780 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008278" } ] }, { "id": "28677083_293386_7", "type": "Species", "text": [ "Bacillus stratosphericus" ], "offsets": [ [ 1016, 1040 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "293386" } ] } ]

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[ { "id": "15887214_title", "type": "title", "text": [ "Ultrasonic glossectomy--simple and bloodless." ], "offsets": [ [ 0, 45 ] ] }, { "id": "15887214_abstract", "type": "abstract", "text": [ "BACKGROUND: The aim of the study was the evaluation of the feasibility of glossectomy using an ultrasonic-activated surgical instrument. METHODS: This was a prospective study of 13 consecutive patients who underwent glossectomy (12 partial and one total) for carcinoma of tongue with the use of ultrasonic scissors. RESULTS: All 13 patients had glossectomy, with median blood loss of 0 mL. The glossectomies were done with an ultrasonic dissector alone. None of the glossectomies required diathermy, ligature, plication, or other methods for hemostasis. The lingual artery and veins of all 13 patients were controlled by use of the ultrasonic scissors alone. No operative complications occurred, including bleeding or wound healing problems. CONCLUSIONS: The excellent combination of coagulation and the cutting effect of ultrasonic scissors has made glossectomy a simple and bloodless procedure. It is a recommended surgical technique in our surgical armamentarium." ], "offsets": [ [ 46, 1012 ] ] } ]

[ { "id": "15887214_9606_0", "type": "Species", "text": [ "patients" ], "offsets": [ [ 239, 247 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "15887214_MESH:D009369_1", "type": "Disease", "text": [ "carcinoma" ], "offsets": [ [ 305, 314 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "15887214_9606_2", "type": "Species", "text": [ "patients" ], "offsets": [ [ 378, 386 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "15887214_9606_3", "type": "Species", "text": [ "patients" ], "offsets": [ [ 639, 647 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "15887214_MESH:D006470_4", "type": "Disease", "text": [ "bleeding" ], "offsets": [ [ 752, 760 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D006470" } ] } ]

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[ { "id": "1564170_title", "type": "title", "text": [ "Generic orientation for agency nurses." ], "offsets": [ [ 0, 38 ] ] }, { "id": "1564170_abstract", "type": "abstract", "text": [ "The nurse shortage in hospitals has brought increased entry routes to RNs. One is the employment agency. This pool of nurses has facilitated staffing, but concerned administrators struggle to meet accreditation criteria for orientation of these employees while containing costs. One method is a generic orientation program. The result is a cost savings for hospital administrators, a successful continuing education program, and an assurance of the education/training of employees hired through outside agencies." ], "offsets": [ [ 39, 551 ] ] } ]

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[ { "id": "32102779_title", "type": "title", "text": [ "Acute Nicotine Exposure Alters Ventral Tegmental Area Inhibitory Transmission and Promotes Diazepam Consumption." ], "offsets": [ [ 0, 112 ] ] }, { "id": "32102779_abstract", "type": "abstract", "text": [ "Nicotine use increases the risk for subsequent abuse of other addictive drugs, but the biological basis underlying this risk remains largely unknown. Interactions between nicotine and other drugs of abuse may arise from nicotine-induced neural adaptations in the mesolimbic dopamine (DA) system, a common pathway for the reinforcing effects of many addictive substances. Previous work identified nicotine-induced neuroadaptations that alter inhibitory transmission in the ventral tegmental area (VTA). Here, we test whether nicotine-induced dysregulation of GABAergic signaling within the VTA increases the vulnerability for benzodiazepine abuse that has been reported in smokers. We demonstrate in rats that nicotine exposure dysregulates diazepam-induced inhibition of VTA GABA neurons and increases diazepam consumption. In VTA GABA neurons, nicotine impaired KCC2-mediated chloride extrusion, depolarized the GABAA reversal potential, and shifted the pharmacological effect of diazepam on GABA neurons from inhibition toward excitation. In parallel, nicotine-related alterations in GABA signaling observed ex vivo were associated with enhanced diazepam-induced inhibition of lateral VTA DA neurons in vivo Targeting KCC2 with the agonist CLP290 normalized diazepam-induced effects on VTA GABA transmission and reduced diazepam consumption following nicotine administration to the control level. Together, our results provide insights into midbrain circuit alterations resulting from nicotine exposure that contribute to the abuse of other drugs, such as benzodiazepines." ], "offsets": [ [ 113, 1687 ] ] } ]

[ { "id": "32102779_MESH:D009538_0", "type": "Chemical", "text": [ "Nicotine" ], "offsets": [ [ 6, 14 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D003975_1", "type": "Chemical", "text": [ "Diazepam" ], "offsets": [ [ 91, 99 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003975" } ] }, { "id": "32102779_MESH:D009538_2", "type": "Chemical", "text": [ "Nicotine" ], "offsets": [ [ 113, 121 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D009538_3", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 284, 292 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D009538_4", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 333, 341 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D004298_5", "type": "Chemical", "text": [ "dopamine" ], "offsets": [ [ 387, 395 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004298" } ] }, { "id": "32102779_MESH:D004298_6", "type": "Chemical", "text": [ "DA" ], "offsets": [ [ 397, 399 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004298" } ] }, { "id": "32102779_MESH:D009538_7", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 509, 517 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D009538_8", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 637, 645 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D001569_9", "type": "Chemical", "text": [ "benzodiazepine" ], "offsets": [ [ 738, 752 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001569" } ] }, { "id": "32102779_10116_10", "type": "Species", "text": [ "rats" ], "offsets": [ [ 812, 816 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10116" } ] }, { "id": "32102779_MESH:D009538_11", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 822, 830 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D003975_12", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 853, 861 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003975" } ] }, { "id": "32102779_MESH:D005680_13", "type": "Chemical", "text": [ "GABA" ], "offsets": [ [ 888, 892 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005680" } ] }, { "id": "32102779_MESH:D003975_14", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 915, 923 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003975" } ] }, { "id": "32102779_MESH:D005680_15", "type": "Chemical", "text": [ "GABA" ], "offsets": [ [ 944, 948 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005680" } ] }, { "id": "32102779_MESH:D009538_16", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 958, 966 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_171373_17", "type": "Gene", "text": [ "KCC2" ], "offsets": [ [ 976, 980 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "171373" } ] }, { "id": "32102779_MESH:D002712_18", "type": "Chemical", "text": [ "chloride" ], "offsets": [ [ 990, 998 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002712" } ] }, { "id": "32102779_-_19", "type": "Chemical", "text": [ "GABAA" ], "offsets": [ [ 1026, 1031 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "32102779_MESH:D003975_20", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 1094, 1102 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003975" } ] }, { "id": "32102779_MESH:D005680_21", "type": "Chemical", "text": [ "GABA" ], "offsets": [ [ 1106, 1110 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005680" } ] }, { "id": "32102779_MESH:D009538_22", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 1167, 1175 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D005680_23", "type": "Chemical", "text": [ "GABA" ], "offsets": [ [ 1199, 1203 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005680" } ] }, { "id": "32102779_MESH:D003975_24", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 1261, 1269 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003975" } ] }, { "id": "32102779_MESH:D004298_25", "type": "Chemical", "text": [ "DA" ], "offsets": [ [ 1304, 1306 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D004298" } ] }, { "id": "32102779_171373_26", "type": "Gene", "text": [ "KCC2" ], "offsets": [ [ 1333, 1337 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "171373" } ] }, { "id": "32102779_-_27", "type": "Chemical", "text": [ "CLP290" ], "offsets": [ [ 1355, 1361 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "32102779_MESH:D003975_28", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 1373, 1381 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003975" } ] }, { "id": "32102779_MESH:D005680_29", "type": "Chemical", "text": [ "GABA" ], "offsets": [ [ 1405, 1409 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D005680" } ] }, { "id": "32102779_MESH:D003975_30", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 1435, 1443 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D003975" } ] }, { "id": "32102779_MESH:D009538_31", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 1466, 1474 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D009538_32", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 1600, 1608 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009538" } ] }, { "id": "32102779_MESH:D001569_33", "type": "Chemical", "text": [ "benzodiazepines" ], "offsets": [ [ 1671, 1686 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001569" } ] } ]

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[ { "id": "34515377_title", "type": "title", "text": [ "Osteoporosis and Dementia: Establishing a Link." ], "offsets": [ [ 0, 47 ] ] }, { "id": "34515377_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 48, 48 ] ] } ]

[ { "id": "34515377_MESH:D010024_0", "type": "Disease", "text": [ "Osteoporosis and Dementia" ], "offsets": [ [ 0, 25 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010024" } ] } ]

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[ { "id": "28577528_title", "type": "title", "text": [ "Factors associated with the occurrence of injuries requiring hospital transfer among older and working-age pedestrians in Kurume, Japan." ], "offsets": [ [ 0, 136 ] ] }, { "id": "28577528_abstract", "type": "abstract", "text": [ "BACKGROUND: Pedestrian injuries among older people tend to occur near their residence. However, knowledge regarding whether distance travelled from home to the injury site or road environmental/socioeconomic factors affect injury severity remains limited. METHODS: A cross-sectional study was performed using injury registry data from the Kurume City Fire Department, Japan. Distance travelled from home was determined with geographic information system (GIS) software. Data were analyzed for potential association with injury occurrence and severity, with stratification by age. Signal detection analysis using 10 variables was applied to identify factors associated with the occurrence of severe pedestrian injuries. RESULTS: Among the 545 adult pedestrian injuries reviewed, the factors associated with the occurrence of severe pedestrian injuries for older people and working-age people were evaluated, focusing on the effect of the network distance travelled from home to injury site. Network distance travelled from home to injury site was not associated with the occurrence of severe pedestrian injuries among older people. By applying signal detection analysis, for older people, higher socioeconomic status, wider road width per lane, and higher aging rate in the residential area were significant factors, and for working-age pedestrians, longer network distance travelled between injury place and their residential area and a higher aging rate in the residential area were significantly associated. CONCLUSIONS: To reduce severe pedestrian injuries among older people, improvement of road infrastructure in areas with wider roads, higher socioeconomic status and higher aging rates is required." ], "offsets": [ [ 137, 1842 ] ] } ]

[ { "id": "28577528_9606_0", "type": "Species", "text": [ "people" ], "offsets": [ [ 181, 187 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "28577528_9606_1", "type": "Species", "text": [ "people" ], "offsets": [ [ 998, 1004 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "28577528_9606_2", "type": "Species", "text": [ "people" ], "offsets": [ [ 1021, 1027 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "28577528_9606_3", "type": "Species", "text": [ "people" ], "offsets": [ [ 1260, 1266 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "28577528_9606_4", "type": "Species", "text": [ "people" ], "offsets": [ [ 1317, 1323 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "28577528_9606_5", "type": "Species", "text": [ "people" ], "offsets": [ [ 1709, 1715 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "21673126_title", "type": "title", "text": [ "Exposure to pesticides and metal contaminants of fertilizer among tree planters." ], "offsets": [ [ 0, 80 ] ] }, { "id": "21673126_abstract", "type": "abstract", "text": [ "In British Columbia, Canada, harvested forests are manually replanted by seasonal workers. The work is known to be physically demanding and ergonomically difficult, and recently, there have been concerns over chemical exposures due to pesticide residues on seedlings, fertilizers (often applied alongside seedlings), and potential metal contamination of these fertilizers. This study aimed to characterize metal and pesticide exposure among a sample of British Columbia tree planters. Between May 2006 and April 2007, exposure measurements were taken from 54 tree planters at five geographically disperse worksites throughout British Columbia. Four worksites were using fertilizer and one was not. Metal concentrations were measured by inductively coupled plasma mass spectrometry on post-shift hand wipes, full-shift personal air sample, bulk soil, seedling root balls, and fertilizer samples. Pesticides were measured on post-shift hand wipes and on bulk seedling samples. Seedling nursery pesticide application records were used to focus pesticide analyses on pesticides known to have been applied to the seedlings used at the study sites. Carbamate pesticides were analyzed by high-performance liquid chromatography/mass spectroscopy and all other pesticides by gas chromatography mass spectrometry. No evidence was found that tree planters who worked with fertilizer were at an elevated risk of exposure to arsenic, lead, cadmium, chromium, and nickel relative to tree planters who did not. Pesticide residues were found on seedlings taken from work sites early in the tree planting season in April 2007. At these worksites, the fungicides chlorothalonil and iprodione were found on the skin of workers at low levels (range 0.37-106.3 ng cm(-2) and 0.48-15.9 ng cm(-2), respectively), providing evidence for exposure potential. Very poor hygiene conditions were observed at all tree planting work sites. Hand washing facilities were not available at work sites and only 5.6% of subjects reported hand washing during the work day, including prior to eating or smoking. Gloves were worn by all subjects but no personal protective equipment programs existed to train workers in the correct use or selection of gloves, and consequentially, many glove choices were inappropriate. The lack of hand washing facilities combined with incorrect glove use could increase the duration of dermal exposure and increase the risk of hand-to-mouth ingestion exposure." ], "offsets": [ [ 81, 2536 ] ] } ]

[ { "id": "21673126_MESH:D008670_0", "type": "Chemical", "text": [ "metal" ], "offsets": [ [ 27, 32 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008670" } ] }, { "id": "21673126_OMIM:176500_1", "type": "Disease", "text": [ "British Columbia" ], "offsets": [ [ 84, 100 ] ], "normalized": [ { "db_name": "mesh", "db_id": "OMIM:176500" } ] }, { "id": "21673126_MESH:D008670_2", "type": "Chemical", "text": [ "metal" ], "offsets": [ [ 487, 492 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008670" } ] }, { "id": "21673126_OMIM:176500_3", "type": "Disease", "text": [ "British Columbia" ], "offsets": [ [ 534, 550 ] ], "normalized": [ { "db_name": "mesh", "db_id": "OMIM:176500" } ] }, { "id": "21673126_OMIM:176500_4", "type": "Disease", "text": [ "British Columbia" ], "offsets": [ [ 707, 723 ] ], "normalized": [ { "db_name": "mesh", "db_id": "OMIM:176500" } ] }, { "id": "21673126_MESH:D008670_5", "type": "Chemical", "text": [ "Metal" ], "offsets": [ [ 779, 784 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008670" } ] }, { "id": "21673126_MESH:D002219_6", "type": "Chemical", "text": [ "Carbamate" ], "offsets": [ [ 1224, 1233 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002219" } ] }, { "id": "21673126_MESH:D001151_7", "type": "Chemical", "text": [ "arsenic" ], "offsets": [ [ 1493, 1500 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D001151" } ] }, { "id": "21673126_MESH:D002104_8", "type": "Chemical", "text": [ "cadmium" ], "offsets": [ [ 1508, 1515 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002104" } ] }, { "id": "21673126_MESH:D002857_9", "type": "Chemical", "text": [ "chromium" ], "offsets": [ [ 1517, 1525 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002857" } ] }, { "id": "21673126_MESH:D009532_10", "type": "Chemical", "text": [ "nickel" ], "offsets": [ [ 1531, 1537 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009532" } ] }, { "id": "21673126_MESH:C005806_11", "type": "Chemical", "text": [ "chlorothalonil" ], "offsets": [ [ 1726, 1740 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C005806" } ] }, { "id": "21673126_MESH:C033148_12", "type": "Chemical", "text": [ "iprodione" ], "offsets": [ [ 1745, 1754 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C033148" } ] } ]

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[ { "id": "8976048_title", "type": "title", "text": [ "Intravascular carbon dioxide monitoring using micro-flow colorimetry." ], "offsets": [ [ 0, 69 ] ] }, { "id": "8976048_abstract", "type": "abstract", "text": [ "An intravascular carbon dioxide sensor is investigated which employs continuous perfusion of micro-quantities of reagent through silicone membrane tubing in contact with blood. Blood is sampled from a vessel by periodic withdrawal-reinfusion through a catheter and passes by the sensor membrane tubing integrated into the catheter system. Blood CO2 equilibrates across the silicone membrane causing a color change in the reagent micro-flow stream that is detected by an optical cell external to the vessel. In vivo trials on pigs demonstrate a stable sensor response, a fast response time, and high signal-to-noise ratios. The sensor also exhibits an immunity to temperature changes, reduced intravascular blood flow, photobleaching, and leaching. It has a 2 min response time, a +/-2 mmHg resolution, and minimal drift over a 12 h duration. Using a pig model, measured values compared with true values indicate a 0.998 correlation coefficient, a 1.3 mmHg precision, and a 1.7 mmHg bias." ], "offsets": [ [ 70, 1057 ] ] } ]

[ { "id": "8976048_MESH:D002245_0", "type": "Chemical", "text": [ "carbon dioxide" ], "offsets": [ [ 14, 28 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "8976048_MESH:D002245_1", "type": "Chemical", "text": [ "carbon dioxide" ], "offsets": [ [ 87, 101 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "8976048_MESH:D012828_2", "type": "Chemical", "text": [ "silicone" ], "offsets": [ [ 199, 207 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012828" } ] }, { "id": "8976048_MESH:D002245_3", "type": "Chemical", "text": [ "CO2" ], "offsets": [ [ 415, 418 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002245" } ] }, { "id": "8976048_MESH:D012828_4", "type": "Chemical", "text": [ "silicone" ], "offsets": [ [ 443, 451 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012828" } ] }, { "id": "8976048_9823_5", "type": "Species", "text": [ "pigs" ], "offsets": [ [ 595, 599 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9823" } ] }, { "id": "8976048_9823_6", "type": "Species", "text": [ "pig" ], "offsets": [ [ 920, 923 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9823" } ] } ]

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[ { "id": "21719475_title", "type": "title", "text": [ "A trifle of management." ], "offsets": [ [ 0, 23 ] ] }, { "id": "21719475_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 24, 24 ] ] } ]

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[ { "id": "19592768_title", "type": "title", "text": [ "Cost effectiveness of virtual reality graded exposure therapy with physiological monitoring for the treatment of combat related post traumatic stress disorder." ], "offsets": [ [ 0, 159 ] ] }, { "id": "19592768_abstract", "type": "abstract", "text": [ "Virtual Reality Graded Exposure Therapy (VRGET) is an effective treatment for combat-related PTSD. We summarize the outcomes of a VRGET pilot study with 12 participants who completed one to multiple combat tours in support of the War on Terrorism and who were subsequently diagnosed with combat-related PTSD. Details of the collaborative program amongst the Virtual Reality Medical Center (VRMC), Office of Naval Research, the Naval Medical Center San Diego (NMCSD) and the Navy Hospital Camp Pendleton are discussed as is the VRGET outcomes of significant reductions in PTSD symptoms severity. We also described the estimated cost-effectiveness of VRGET for the treatment of combat-related PTSD, as contrasted to Treatment as Usual (TAU) for combat-related PTSD." ], "offsets": [ [ 160, 923 ] ] } ]

[ { "id": "19592768_MESH:D040921_0", "type": "Disease", "text": [ "traumatic stress disorder" ], "offsets": [ [ 133, 158 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D040921" } ] }, { "id": "19592768_MESH:D013313_1", "type": "Disease", "text": [ "PTSD" ], "offsets": [ [ 253, 257 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013313" } ] }, { "id": "19592768_9606_2", "type": "Species", "text": [ "participants" ], "offsets": [ [ 316, 328 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "19592768_MESH:D020184_3", "type": "Disease", "text": [ "Terrorism" ], "offsets": [ [ 397, 406 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020184" } ] }, { "id": "19592768_MESH:D013313_4", "type": "Disease", "text": [ "PTSD" ], "offsets": [ [ 463, 467 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013313" } ] }, { "id": "19592768_MESH:D013313_5", "type": "Disease", "text": [ "PTSD" ], "offsets": [ [ 731, 735 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013313" } ] }, { "id": "19592768_-_6", "type": "Chemical", "text": [ "VRGET" ], "offsets": [ [ 809, 814 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "19592768_MESH:D013313_7", "type": "Disease", "text": [ "PTSD" ], "offsets": [ [ 851, 855 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013313" } ] }, { "id": "19592768_4137_8", "type": "Gene", "text": [ "TAU" ], "offsets": [ [ 894, 897 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "4137" } ] }, { "id": "19592768_MESH:D013313_9", "type": "Disease", "text": [ "PTSD" ], "offsets": [ [ 918, 922 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D013313" } ] } ]

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[ { "id": "3274369_title", "type": "title", "text": [ "Renal transplantation in Nordic children." ], "offsets": [ [ 0, 41 ] ] }, { "id": "3274369_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 42, 42 ] ] } ]

[ { "id": "3274369_9606_0", "type": "Species", "text": [ "children" ], "offsets": [ [ 32, 40 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "25670985_title", "type": "title", "text": [ "Molecular cleft or tweezer compounds derived from trioxabicyclo[3.3.1]nonadiene diisocyanate and diacid dichloride." ], "offsets": [ [ 0, 115 ] ] }, { "id": "25670985_abstract", "type": "abstract", "text": [ "The structures of two derivatives of the bisdioxine diisocyanate 1, the bisurea 4 and the biscarbamate 5, are established by X-ray crystallography and DFT calculations. These compounds possess endo,endo structures, in the case of the bisurea 4 with two nearly parallel pendant chains. The X-ray structures are reproduced very well by DFT calculations. Similar endo,endo conformations are calculated for the bisamide crown ether derivatives 7, where two proximate and nearly parallel crown ether units endow the molecules with a claw-like molecular cleft or tweezer structure as evidenced by an enhanced ability to extract some alkali, alkaline earth and rare earth metal ions." ], "offsets": [ [ 116, 792 ] ] } ]

[ { "id": "25670985_MESH:D002972_0", "type": "Disease", "text": [ "cleft" ], "offsets": [ [ 10, 15 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002972" } ] }, { "id": "25670985_-_1", "type": "Chemical", "text": [ "tweezer compounds" ], "offsets": [ [ 19, 36 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25670985_-_2", "type": "Chemical", "text": [ "trioxabicyclo[3.3.1]nonadiene diisocyanate" ], "offsets": [ [ 50, 92 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25670985_-_3", "type": "Chemical", "text": [ "diacid dichloride" ], "offsets": [ [ 97, 114 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25670985_-_4", "type": "Chemical", "text": [ "bisdioxine diisocyanate" ], "offsets": [ [ 157, 180 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25670985_-_5", "type": "Chemical", "text": [ "bisurea" ], "offsets": [ [ 188, 195 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25670985_-_6", "type": "Chemical", "text": [ "biscarbamate" ], "offsets": [ [ 206, 218 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25670985_-_7", "type": "Chemical", "text": [ "bisurea" ], "offsets": [ [ 350, 357 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25670985_-_8", "type": "Chemical", "text": [ "bisamide" ], "offsets": [ [ 523, 531 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "25670985_MESH:D043844_9", "type": "Chemical", "text": [ "crown ether" ], "offsets": [ [ 532, 543 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D043844" } ] }, { "id": "25670985_MESH:D043844_10", "type": "Chemical", "text": [ "crown ether" ], "offsets": [ [ 599, 610 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D043844" } ] }, { "id": "25670985_MESH:D002972_11", "type": "Disease", "text": [ "cleft" ], "offsets": [ [ 664, 669 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002972" } ] }, { "id": "25670985_MESH:D008670_12", "type": "Chemical", "text": [ "metal" ], "offsets": [ [ 781, 786 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D008670" } ] } ]

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[ { "id": "10863202_title", "type": "title", "text": [ "[ENT diseases associated with allergic rhinitis: a review of the literature]." ], "offsets": [ [ 0, 77 ] ] }, { "id": "10863202_abstract", "type": "abstract", "text": [ "Various diseases of the upper airway, such as acute or chronic sinusitis, otitis media, pharyngitis or laryngitis, snoring and sleep apnea syndrom, may be associated with allergic rhinitis. The relationship between these pathologies and the allergic rhinitis has been well established from a clinical and epidemiological point of view, but the pathophysiological mechanisms remain uncertain. A good knowledge of symptoms and the performance of explorations, such as nasal endoscopy for sinusitis, are important in order to take care of these associated diseases. When upper airway diseases are associated with allergic rhinitis, treatment of rhinitis must generally be reinforced. Treament of associated disease will be specific to each disease, and sometimes surgery is required, specially in case of chronic sinusitis. In all cases, the pneumologist, allergologist and ENT physician should work in close collaboration." ], "offsets": [ [ 78, 998 ] ] } ]

[ { "id": "10863202_MESH:D065631_0", "type": "Disease", "text": [ "allergic rhinitis" ], "offsets": [ [ 30, 47 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D065631" } ] }, { "id": "10863202_MESH:D012852_1", "type": "Disease", "text": [ "sinusitis" ], "offsets": [ [ 141, 150 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012852" } ] }, { "id": "10863202_MESH:D010031_2", "type": "Disease", "text": [ "otitis" ], "offsets": [ [ 152, 158 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010031" } ] }, { "id": "10863202_MESH:D010608_3", "type": "Disease", "text": [ "pharyngitis" ], "offsets": [ [ 166, 177 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010608" } ] }, { "id": "10863202_MESH:D007827_4", "type": "Disease", "text": [ "laryngitis" ], "offsets": [ [ 181, 191 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007827" } ] }, { "id": "10863202_MESH:D012891_5", "type": "Disease", "text": [ "sleep apnea syndrom" ], "offsets": [ [ 205, 224 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012891" } ] }, { "id": "10863202_MESH:D065631_6", "type": "Disease", "text": [ "allergic rhinitis" ], "offsets": [ [ 249, 266 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D065631" } ] }, { "id": "10863202_MESH:D065631_7", "type": "Disease", "text": [ "allergic rhinitis" ], "offsets": [ [ 319, 336 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D065631" } ] }, { "id": "10863202_MESH:D012852_8", "type": "Disease", "text": [ "sinusitis" ], "offsets": [ [ 564, 573 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012852" } ] }, { "id": "10863202_MESH:D065631_9", "type": "Disease", "text": [ "allergic rhinitis" ], "offsets": [ [ 688, 705 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D065631" } ] }, { "id": "10863202_MESH:D012220_10", "type": "Disease", "text": [ "rhinitis" ], "offsets": [ [ 720, 728 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012220" } ] }, { "id": "10863202_MESH:D012852_11", "type": "Disease", "text": [ "sinusitis" ], "offsets": [ [ 888, 897 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D012852" } ] } ]

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[ { "id": "968517_title", "type": "title", "text": [ "Ethnic self-identity: a comparison of ingroup evaluations." ], "offsets": [ [ 0, 58 ] ] }, { "id": "968517_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 59, 59 ] ] } ]

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[ { "id": "5372615_title", "type": "title", "text": [ "[Demonstration of specific 19S antibody-producing cells in the tonsil]." ], "offsets": [ [ 0, 71 ] ] }, { "id": "5372615_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 72, 72 ] ] } ]

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[ { "id": "7716394_title", "type": "title", "text": [ "Mixed populations of Trypanosoma brucei in wild Glossina palpalis palpalis." ], "offsets": [ [ 0, 75 ] ] }, { "id": "7716394_abstract", "type": "abstract", "text": [ "In many previous characterization studies of Trypanozoon, isolates have been subpassaged numerous times in laboratory rodents until a quantity of trypanosomes sufficient for analysis has been obtained. In addition to the numerous biochemical effects of such a process on the parasite, it appears probable that adaptation to an unnatural host may also serve to filter out less virulent populations from mixed infections, leading to an underestimate of the true level of genetic diversity. By the early cloning of trypanosomes from susceptible captive flies infected from the primary isolate--the midgut of a wild tsetse--the present study provides evidence of the range of genetically different Trypanosoma brucei populations which may coexist within the midgut of individual tsetse flies in nature. The three primary isolates from tsetse yielded one, five and nine genetically distinct populations. Cloned populations were confirmed as T. brucei using the polymerase chain reaction, and were characterized by karyotype analysis and multilocus isoenzyme electrophoresis. These data allowed a limited assessment of the level of genetic variability in natural populations of T. brucei." ], "offsets": [ [ 76, 1258 ] ] } ]

[ { "id": "7716394_5691_0", "type": "Species", "text": [ "Trypanosoma brucei" ], "offsets": [ [ 21, 39 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "5691" } ] }, { "id": "7716394_66268_1", "type": "Species", "text": [ "Glossina palpalis palpalis" ], "offsets": [ [ 48, 74 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "66268" } ] }, { "id": "7716394_MESH:D007239_2", "type": "Disease", "text": [ "infections" ], "offsets": [ [ 484, 494 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007239" } ] }, { "id": "7716394_5691_3", "type": "Species", "text": [ "Trypanosoma brucei" ], "offsets": [ [ 770, 788 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "5691" } ] }, { "id": "7716394_7393_4", "type": "Species", "text": [ "tsetse flies" ], "offsets": [ [ 851, 863 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "7393" } ] }, { "id": "7716394_5691_5", "type": "Species", "text": [ "T. brucei" ], "offsets": [ [ 1012, 1021 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "5691" } ] }, { "id": "7716394_5691_6", "type": "Species", "text": [ "T. brucei" ], "offsets": [ [ 1248, 1257 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "5691" } ] } ]

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[ { "id": "5038544_title", "type": "title", "text": [ "[Cleidocranial dysostosis in a patient with hypophosphatasia]." ], "offsets": [ [ 0, 62 ] ] }, { "id": "5038544_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 63, 63 ] ] } ]

[ { "id": "5038544_MESH:D002973_0", "type": "Disease", "text": [ "Cleidocranial dysostosis" ], "offsets": [ [ 1, 25 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002973" } ] }, { "id": "5038544_9606_1", "type": "Species", "text": [ "patient" ], "offsets": [ [ 31, 38 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "5038544_MESH:C562440_2", "type": "Disease", "text": [ "hypophosphatasia" ], "offsets": [ [ 44, 60 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C562440" } ] } ]

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[ { "id": "20024366_title", "type": "title", "text": [ "Template-controlled synthesis of a planar [16]ane-P2C(NHC)2 macrocycle." ], "offsets": [ [ 0, 71 ] ] }, { "id": "20024366_abstract", "type": "abstract", "text": [ "Reaction of tetraphosphine platinum(II) complexes with 2-azidoethyl isocyanide 3 in methanol leads to complexes with two trans-coordinated NH,NH-stabilized carbene ligands 6(X)(2). Complexes 6(X)(2) react with phenyldivinylphosphine under substitution of the remaining phosphine ligands followed by an intramolecular hydroamination reaction to produce complex 1(PF(6))(2) with a macrocyclic [16]ane-P(2)C(NHC)(2) ligand." ], "offsets": [ [ 72, 492 ] ] } ]

[ { "id": "20024366_-_0", "type": "Chemical", "text": [ "[16]ane-P2C(NHC)2" ], "offsets": [ [ 42, 59 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "20024366_-_1", "type": "Chemical", "text": [ "tetraphosphine platinum" ], "offsets": [ [ 84, 107 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "20024366_-_2", "type": "Chemical", "text": [ "2-azidoethyl isocyanide" ], "offsets": [ [ 127, 150 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "20024366_MESH:D000432_3", "type": "Chemical", "text": [ "methanol" ], "offsets": [ [ 156, 164 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000432" } ] }, { "id": "20024366_MESH:C030011_4", "type": "Chemical", "text": [ "carbene" ], "offsets": [ [ 228, 235 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C030011" } ] }, { "id": "20024366_-_5", "type": "Chemical", "text": [ "phenyldivinylphosphine" ], "offsets": [ [ 282, 304 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "20024366_MESH:C044646_6", "type": "Chemical", "text": [ "phosphine" ], "offsets": [ [ 341, 350 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C044646" } ] }, { "id": "20024366_-_7", "type": "Chemical", "text": [ "(PF(6))" ], "offsets": [ [ 433, 440 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "20024366_MESH:D020216_8", "type": "Disease", "text": [ "ane-P(2)C" ], "offsets": [ [ 467, 476 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020216" } ] } ]

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[ { "id": "10564797_title", "type": "title", "text": [ "Phylogenetic relationships of symbiotic spirochetes in the gut of diverse termites." ], "offsets": [ [ 0, 83 ] ] }, { "id": "10564797_abstract", "type": "abstract", "text": [ "Phylogenetic relationships of symbiotic spirochetes in the gut of diverse termites were analyzed without cultivation of these microorganisms. A portion of the 16S rDNA (ca. 850 bp) was amplified directly from DNA of the mixed population in the gut by PCR and cloned. A total of 30 spirochetal phylotypes affiliated with the treponemes were identified from four termite species and they were compared with those already reported from other termites. They represented separate lines of descent from any known species of Treponema, and they were divided into two discrete clusters; one was related to Spirochaeta stenostrepta and S. caldaria, and the other was grouped together with members of the Treponema bryantii subgroup. Although some sequences from evolutionarily related termites showed close similarity, most of the sequences of spirochetes were dissimilar among different termite species, and spirochetal sequences from a single termite species occurred in several distinct phylogenetic positions. These findings suggest that termites constitute a rich reservoir of novel spirochetal diversity and that evolution of the symbiosis is not simple." ], "offsets": [ [ 84, 1235 ] ] } ]

[ { "id": "10564797_1912919_0", "type": "Species", "text": [ "termites" ], "offsets": [ [ 74, 82 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1912919" } ] }, { "id": "10564797_1912919_1", "type": "Species", "text": [ "termites" ], "offsets": [ [ 158, 166 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1912919" } ] }, { "id": "10564797_1912919_2", "type": "Species", "text": [ "termites" ], "offsets": [ [ 523, 531 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1912919" } ] }, { "id": "10564797_163_3", "type": "Species", "text": [ "Treponema" ], "offsets": [ [ 602, 611 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "163" } ] }, { "id": "10564797_152_4", "type": "Species", "text": [ "Spirochaeta stenostrepta" ], "offsets": [ [ 682, 706 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "152" } ] }, { "id": "10564797_215591_5", "type": "Species", "text": [ "S. caldaria" ], "offsets": [ [ 711, 722 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "215591" } ] }, { "id": "10564797_163_6", "type": "Species", "text": [ "Treponema bryantii" ], "offsets": [ [ 779, 797 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "163" } ] }, { "id": "10564797_1912919_7", "type": "Species", "text": [ "termites" ], "offsets": [ [ 860, 868 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1912919" } ] }, { "id": "10564797_1912919_8", "type": "Species", "text": [ "termites" ], "offsets": [ [ 1117, 1125 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "1912919" } ] } ]

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[ { "id": "14223516_title", "type": "title", "text": [ "[ON CONGENITAL ATRESIA OF THE EXTRAHEPATIC BILE DUCTS. SUCCESSFUL SURGICAL TREATMENT OF A HEPATIC DUCT OCCLUSION]." ], "offsets": [ [ 0, 114 ] ] }, { "id": "14223516_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 115, 115 ] ] } ]

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[ { "id": "36056698_title", "type": "title", "text": [ "CD24 blockade promotes anti-tumor immunity in oral squamous cell carcinoma." ], "offsets": [ [ 0, 75 ] ] }, { "id": "36056698_abstract", "type": "abstract", "text": [ "OBJECTIVES: Our study elucidates the prognostic role of cluster of differentiation (CD) 24 expression in oral squamous cell carcinoma (OSCC) and determines whether targeting CD24 enhances the anti-tumor immune response by inhibiting tumor-associated macrophages (TAMs). MATERIALS AND METHODS: The expression of CD24 and CD68 was analyzed immunohistochemically via tissue microarrays constructed using 56 cohorts of patients with OSCC and 20 control specimens. Further, CD24 was inhibited in an allograft squamous cell carcinoma (SCC) related mouse model with CD24mAb to determine the tumor volume and weight. Changes in immune cells such as TAMs and T cells in the tumor microenvironment (TME) were analyzed by Flow cytometry. The expression of CD4, CD8, and Ki67 was analyzed via immunohistochemistry. The inhibition of CD24 was confirmed by Western blot and immunohistochemistry. RESULTS: CD24 was overexpressed in OSCC. High expression of CD24 indicated poor survival in patients with OSCC (p = 0.0334). CD24 expression was significantly correlated with CD68 (p = 0.0424). The inhibition of CD24 delayed tumor growth in vivo. A decrease in TAMs number and an increase in T cell number were confirmed, while the ability of tumor proliferation was impaired. CONCLUSION: Targeting CD24 could enhance anti-tumor immune response by inhibiting TAMs." ], "offsets": [ [ 76, 1422 ] ] } ]

[ { "id": "36056698_100133941_0", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_MESH:D009369_1", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "36056698_MESH:D002294_2", "type": "Disease", "text": [ "oral squamous cell carcinoma" ], "offsets": [ [ 46, 74 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002294" } ] }, { "id": "36056698_100133941_3", "type": "Gene", "text": [ "cluster of differentiation (CD) 24" ], "offsets": [ [ 132, 166 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_MESH:D002294_4", "type": "Disease", "text": [ "oral squamous cell carcinoma" ], "offsets": [ [ 181, 209 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002294" } ] }, { "id": "36056698_100133941_5", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 250, 254 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_MESH:D009369_6", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 273, 278 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "36056698_MESH:D009369_7", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 309, 314 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "36056698_100133941_8", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 387, 391 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_968_9", "type": "Gene", "text": [ "CD68" ], "offsets": [ [ 396, 400 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "968" } ] }, { "id": "36056698_9606_10", "type": "Species", "text": [ "patients" ], "offsets": [ [ 491, 499 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36056698_12484_11", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 545, 549 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "12484" } ] }, { "id": "36056698_MESH:D002294_12", "type": "Disease", "text": [ "squamous cell carcinoma" ], "offsets": [ [ 580, 603 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002294" } ] }, { "id": "36056698_10090_13", "type": "Species", "text": [ "mouse" ], "offsets": [ [ 618, 623 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "10090" } ] }, { "id": "36056698_MESH:D009369_14", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 660, 665 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "36056698_-_15", "type": "Chemical", "text": [ "TAMs" ], "offsets": [ [ 717, 721 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "36056698_MESH:D009369_16", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 741, 746 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "36056698_920_17", "type": "Gene", "text": [ "CD4" ], "offsets": [ [ 821, 824 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "920" } ] }, { "id": "36056698_925_18", "type": "Gene", "text": [ "CD8" ], "offsets": [ [ 826, 829 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "925" } ] }, { "id": "36056698_100133941_19", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 897, 901 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_100133941_20", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 967, 971 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_100133941_21", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 1018, 1022 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_9606_22", "type": "Species", "text": [ "patients" ], "offsets": [ [ 1050, 1058 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] }, { "id": "36056698_100133941_23", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 1083, 1087 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_968_24", "type": "Gene", "text": [ "CD68" ], "offsets": [ [ 1133, 1137 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "968" } ] }, { "id": "36056698_100133941_25", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 1170, 1174 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_MESH:D009369_26", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 1183, 1188 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "36056698_-_27", "type": "Chemical", "text": [ "TAMs" ], "offsets": [ [ 1219, 1223 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] }, { "id": "36056698_MESH:D009369_28", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 1301, 1306 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "36056698_100133941_29", "type": "Gene", "text": [ "CD24" ], "offsets": [ [ 1357, 1361 ] ], "normalized": [ { "db_name": "ncbi_gene", "db_id": "100133941" } ] }, { "id": "36056698_MESH:D009369_30", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 1381, 1386 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D009369" } ] }, { "id": "36056698_-_31", "type": "Chemical", "text": [ "TAMs" ], "offsets": [ [ 1417, 1421 ] ], "normalized": [ { "db_name": "mesh", "db_id": "-" } ] } ]

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[ { "id": "22361016_title", "type": "title", "text": [ "Radioactive cesium isotope ratios as a tool for determining dispersal and re-dispersal mechanisms downwind from the Nevada Nuclear Security Site." ], "offsets": [ [ 0, 145 ] ] }, { "id": "22361016_abstract", "type": "abstract", "text": [ "Fractionation of the two longer-lived radioactive cesium isotopes ((135)Cs and (137)Cs) produced by above ground nuclear tests have been measured and used to clarify the dispersal mechanisms of cesium deposited in the area between the Nevada Nuclear Security Site and Lake Mead in the southwestern United States. Fractionation of these isotopes is due to the 135-decay chain requiring several days to completely decay to (135)Cs, and the 137-decay chain less than one hour decay to (137)Cs. Since the Cs precursors are gases, iodine and xenon, the (135)Cs plume was deposited farther downwind than the (137)Cs plume. Sediment core samples were obtained from the Las Vegas arm of Lake Mead, sub-sampled and analyzed for (135)Cs/(137)Cs ratios by thermal ionization mass spectrometry. The layers proved to have nearly identical highly fractionated isotope ratios. This information is consistent with a model where the cesium was initially deposited onto the land area draining into Lake Mead and the composite from all of the above ground shots subsequently washed onto Lake Mead by high intensity rain and wind storms producing a layering of Cs activity, where each layer is a portion of the composite." ], "offsets": [ [ 146, 1347 ] ] } ]

[ { "id": "22361016_MESH:D002586_0", "type": "Chemical", "text": [ "cesium" ], "offsets": [ [ 12, 18 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_1", "type": "Chemical", "text": [ "cesium" ], "offsets": [ [ 196, 202 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_2", "type": "Chemical", "text": [ "Cs" ], "offsets": [ [ 218, 220 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_3", "type": "Chemical", "text": [ "cesium" ], "offsets": [ [ 340, 346 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_4", "type": "Chemical", "text": [ "Cs" ], "offsets": [ [ 572, 574 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_5", "type": "Chemical", "text": [ "Cs" ], "offsets": [ [ 633, 635 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_6", "type": "Chemical", "text": [ "Cs" ], "offsets": [ [ 647, 649 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D007455_7", "type": "Chemical", "text": [ "iodine" ], "offsets": [ [ 672, 678 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D007455" } ] }, { "id": "22361016_MESH:D014978_8", "type": "Chemical", "text": [ "xenon" ], "offsets": [ [ 683, 688 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D014978" } ] }, { "id": "22361016_MESH:D002586_9", "type": "Chemical", "text": [ "Cs" ], "offsets": [ [ 699, 701 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_10", "type": "Chemical", "text": [ "Cs" ], "offsets": [ [ 753, 755 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_11", "type": "Chemical", "text": [ "cesium" ], "offsets": [ [ 1062, 1068 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] }, { "id": "22361016_MESH:D002586_12", "type": "Chemical", "text": [ "Cs" ], "offsets": [ [ 1287, 1289 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D002586" } ] } ]

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[ { "id": "25475681_title", "type": "title", "text": [ "Transformation of a cadaver population: Analysis of a South African cadaver program, 1921-2013." ], "offsets": [ [ 0, 95 ] ] }, { "id": "25475681_abstract", "type": "abstract", "text": [ "Anatomy has served as a cornerstone in the training of various allied and clinical disciplines and has traditionally been based on dissection of the human body. Thus, to pursue this method of teaching and learning, access to cadavers is of continuing importance. Over a significant period of time unclaimed cadavers have performed an essential role in the teaching of anatomy in South Africa and in Africa. As recent cadaver numbers were declining at the School of Anatomical Sciences, University of the Witwatersrand, Johannesburg and difficulty in procurement was being experienced, the purpose of this study was to critically evaluate the composition of our cadaver population over time so as to provide possible strategies to arrest the decline. A retrospective, quantitative analysis of cadaver records from the School of Anatomical Sciences between 1921 and 2013 was undertaken. Analysis included a comparison of Poisson counts and Fischer's exact test. A significant decrease in the number of cadavers received during the period 2000-2013 and a slow bequest program over the same period of time has led to concerns about the sustainability of teaching anatomy through dissection. Decreases in the numbers of males and cadavers of the black population group occurred between 1990 and 2013, and of bequests from 2000 to 2013. An influence on the cadaver population from a changing political climate and change in socioeconomic status of part of the population was perceived. Changes in sex and population group of the cadavers may have a long-term effect on teaching and research." ], "offsets": [ [ 96, 1681 ] ] } ]

[ { "id": "25475681_9606_0", "type": "Species", "text": [ "human" ], "offsets": [ [ 245, 250 ] ], "normalized": [ { "db_name": "ncbi_taxon", "db_id": "9606" } ] } ]

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[ { "id": "18535235_title", "type": "title", "text": [ "Applied physics. Going with (or against) the flow." ], "offsets": [ [ 0, 50 ] ] }, { "id": "18535235_abstract", "type": "abstract", "text": [ "" ], "offsets": [ [ 51, 51 ] ] } ]

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[ { "id": "27036093_title", "type": "title", "text": [ "A multi-laboratory evaluation of microelectrode array-based measurements of neural network activity for acute neurotoxicity testing." ], "offsets": [ [ 0, 132 ] ] }, { "id": "27036093_abstract", "type": "abstract", "text": [ "There is a need for methods to screen and prioritize chemicals for potential hazard, including neurotoxicity. Microelectrode array (MEA) systems enable simultaneous extracellular recordings from multiple sites in neural networks in real time and thereby provide a robust measure of network activity. In this study, spontaneous activity measurements from primary neuronal cultures treated with three neurotoxic or three non-neurotoxic compounds was evaluated across four different laboratories. All four individual laboratories correctly identifed the neurotoxic compounds chlorpyrifos oxon (an organophosphate insecticide), deltamethrin (a pyrethroid insecticide) and domoic acid (an excitotoxicant). By contrast, the other three compounds (glyphosate, dimethyl phthalate and acetaminophen) considered to be non-neurotoxic (\"negative controls\"), produced only sporadic changes of the measured parameters. The results were consistent across the different laboratories, as all three neurotoxic compounds caused concentration-dependent inhibition of mean firing rate (MFR). Further, MFR appeared to be the most sensitive parameter for effects of neurotoxic compounds, as changes in electrical activity measured by mean frequency intra burst (MFIB), and mean burst duration (MBD) did not result in concentration-response relationships for some of the positive compounds, or required higher concentrations for an effect to be observed. However, greater numbers of compounds need to be tested to confirm this. The results obtained indicate that measurement of spontaneous electrical activity using MEAs provides a robust assessment of compound effects on neural network function." ], "offsets": [ [ 133, 1806 ] ] } ]

[ { "id": "27036093_MESH:D020258_0", "type": "Disease", "text": [ "neurotoxicity" ], "offsets": [ [ 110, 123 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] }, { "id": "27036093_MESH:D020258_1", "type": "Disease", "text": [ "neurotoxicity" ], "offsets": [ [ 228, 241 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] }, { "id": "27036093_MESH:D020258_2", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 532, 542 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] }, { "id": "27036093_MESH:D020258_3", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 556, 566 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] }, { "id": "27036093_MESH:D020258_4", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 684, 694 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] }, { "id": "27036093_MESH:C009618_5", "type": "Chemical", "text": [ "chlorpyrifos oxon" ], "offsets": [ [ 705, 722 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C009618" } ] }, { "id": "27036093_MESH:D010755_6", "type": "Chemical", "text": [ "organophosphate" ], "offsets": [ [ 727, 742 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D010755" } ] }, { "id": "27036093_MESH:C017180_7", "type": "Chemical", "text": [ "deltamethrin" ], "offsets": [ [ 757, 769 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C017180" } ] }, { "id": "27036093_MESH:C012301_8", "type": "Chemical", "text": [ "domoic acid" ], "offsets": [ [ 801, 812 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C012301" } ] }, { "id": "27036093_MESH:C010974_9", "type": "Chemical", "text": [ "glyphosate" ], "offsets": [ [ 874, 884 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C010974" } ] }, { "id": "27036093_MESH:C024629_10", "type": "Chemical", "text": [ "dimethyl phthalate" ], "offsets": [ [ 886, 904 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:C024629" } ] }, { "id": "27036093_MESH:D000082_11", "type": "Chemical", "text": [ "acetaminophen" ], "offsets": [ [ 909, 922 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D000082" } ] }, { "id": "27036093_MESH:D020258_12", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 945, 955 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] }, { "id": "27036093_MESH:D020258_13", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 1114, 1124 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] }, { "id": "27036093_MESH:D020258_14", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 1276, 1286 ] ], "normalized": [ { "db_name": "mesh", "db_id": "MESH:D020258" } ] } ]

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