UNomusa Dube-Ncube ungusopolitiki waseNingizimu Afrika futhi ungusopolitiki osebenza njengoNgqongqoshe wezeziMali KwaZulu-Natal kusukela ngoNovemba 2020. WayenguNgqongqoshe Wezokuthuthukiswa Komnotho, Ezokuvakasha kanye Nezindaba Zemvelo kusukela ngoMeyi 2019 kuze kube nguNovemba 2020. Kusukela ngoJulayi 2009 kuya kuMeyi 2019, wayenguNgqongqoshe Wezokubusa Ngokubambisana Nezindaba Zomdabu. Ngaphambi kokusebenza esiShayamthetho, wayeyinxusa laseNingizimu Afrika eCzech Republic. UDube-Ncube uke waba yimeya yomkhandlu waseNyakatho Central ngaphambi kokuthi uhlanganiswe noMasipala weTheku ngo-2000. Ube esesebenza njengosotswebhu omkhulu womkhandlu weTheku waze waqokwa njengenxusa laseCzech Republic . Uqokelwe esiShayamthetho saKwaZulu-Natali kwathi i-ANC yamqoka njengosotswebhu omkhulu. Wabamba lesi sikhundla kwaze kwaba nguJulayi 2009, lapho uNdunankulu uZweli Mkhize amqoka esikhundleni sokuba nguNgqongqoshe Wezokubusa Ngokubambisana Nezindaba ZoMdabu. USenzo Mchunu wakhethwa njengoNdunankulu ngo-2013, wagcinwa esikhundleni sakhe.UDube-Ncube usesikhundleni ngemuva kokukhethwa kukaWillies Mchunu njengoNdunankulu ngoMeyi 2016. NgoMeyi 2019, waqoka uNgqongqoshe Wezokuthuthukiswa Komnotho, Ezokuvakasha kanye nezeMvelo nguNdunankulu osanda kuqokwa uSihle Zikalala .Ngomhlaka 17 Novemba 2020, uDube-Mncube waqokwa njengoNgqongqoshe wezeziMali, esikhundleni sikaRavi Pillay .