Izizinda ze-WWE zenzeka ngezigaba ezimbili ezisebenzayo zamaprotheni, okungukuthi lezo ezihambisana nobiquitination kanye nalezo ezihlobene ne-poly-ADP ribosylation ( PARP ).Ngakho-ke, izizinda ze- WWE zibamba umsebenzi obalulekile ekudlulisweni kwesiginali, ukonakala kwamaprotheni, ukulungiswa kwe-DNA kanye ne- apoptosis . I WWE lesizinda yaqanjwa ezintathu zalo alondolozwe izinsalela, W no-E izinsalela ( tryptophans futhi glutamate ngokulandelana), futhi kubikezelwa ukuthi ethize ngasolinye amaprotheni-amaprotheni ekusebenzisaneni e ubiquitin futhi Adp ribose lokuhlanganisa izinhlelo (midi Adp ribose polymerase).Lesi sizinda itholakala njengendlela Ngohlelo uphinda ngesikhathi N-ukuphela Deltex, a cytosolic effector ka Notch mkhosi okucatshangwa uxhumano nomsebenzisi N-ukuphela kwe-Notch yokwamukela . Iphinde itholakale njengemodyuli yokuxhumana kuma- protein ubiquination kanye ne-ADP ribosylation protein . Ngaphakathi kwemodyuli ngayinye ye-WWE, izinsalela zakha izakhiwo ezimbili ezifanayo ezibalulekile ekusimeni kwaso.Amamojula amabili e-WWE ahlangana futhi akha umsantsa omkhulu ofanele ukubopha ama-polypeptides anwetshiwe.Amamojula amabili e-WWE amukela ukwakheka okuhlanganisiwe ikakhulu okuqukethe imicu ye-beta, nge- alpha helix eyodwa kumamojula womabili nangengxenye eyengeziwe emfushane ye-helical kusigaba sesibili seWWE.Amamojula amabili we-WWE abamba i- eksisi yokujikeleza kabili. The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation..