Umdlavuza womthondo kuwumdlavuza owakheka esikhumbeni noma izicubu zomthondo.Izimpawu zingafaka ukukhula okungajwayelekile, isilonda noma isilonda esikhunjeni sowesilisa, kanye nokopha noma ukukhipha okunuka kabi. Izici zobungozi zibandakanya i-phimosis (ukungakwazi ukuhoxisa ijwabu lobudoda), ukuvuvukala okungapheli, ukubhema, ukutheleleka nge-HPV, i- condylomata acuminate, ukuba nabalingani abaningi bezocansi, kanye nokuya ocansini usemncane. Cishe ama-95% omdlavuza we-penile angama- squamous cell carcinomas .Ezinye izinhlobo zomdlavuza we-penile njenge- Merkel cell carcinoma, i- cell cell carcinoma, ne- melanoma ngokuvamile azivamile. Ku-2018, kwenzeka emadodeni angama-34,000 futhi kwabangela ukufa kwabantu abayi-15,000. Umdlavuza wePenile ungabonakala njengokubomvu nokucasula epeni ngesikhumba esijiyile ku-glans noma ijwabu langaphakathi noma isilonda, ukukhula kwangaphandle ( exophytic ) noma ukukhula okufana "nomunwe" (papillary). Umdlavuza wePenile ungahambisana nokukhishwa kwe-penile noma ngaphandle kobunzima noma ukushisa noma ukuhayiza ngenkathi uchama (i- dysuria ) nokuphuma kwegazi endodeni. Ukutheleleka nge-HIV —amadoda ane-HIV anengozi ephindwe kasishiyagalombili yokuthola umdlavuza we-penile kunamadoda angenayo i-HIV. I-human papillomavirus -HPV iyingozi ekuthuthukiseni umdlavuza we-penile.