I-Cannabidiol (CBD) iyi-phytocannabinoid eyatholakala ngo-1940. Ingenye yezingama-113 ezikhonjwe ngama-cannabinoids ezitshalweni ze-cannabis nama-akhawunti afinyelela ku-40% kokukhishwa kwesitshalo. Ngo-2018, ucwaningo lomtholampilo nge-cannabidiol lufake nezifundo zokuqala zokukhathazeka, ukuqonda, ukuphazamiseka kokuhamba, nobuhlungu. I-cannabidiol ingathathelwa emzimbeni ngezindlela eziningi, kufaka phakathi ukuhogela intuthu noma umusi we-cannabis, njengesifutho se-aerosol esihlathini, nangomlomo. Kunganikezwa njengamafutha we-CBD aqukethe i-CBD kuphela njengesithako esisebenzayo (asifakwanga i-tetrahydrocannabinol [i-THC] noma i-terpenes), isitshalo se-hemmp egcwele i-CBD egcwele izitshalo, amaphilisi, i-cannabis eyomisiwe, noma njengesixazululo soketshezi esihlinzekiwe. I-CBD ayinayo i-psychoactivity efanayo ne-THC, futhi ingashintsha imiphumela ye-THC emzimbeni uma bobabili bekhona. Kusukela ngonyaka we-2018, indlela yokusebenza yezenzo zemiphumela yayo ye-biological ayikaze inqunywe. E-United States, isidakamizwa se-cannabidiol i-Epidiolex savunywa ngabakwaFood and Drug Administration ngonyaka we-2018 ukwelashwa kwezifo ezimbili zesifo sokuwa. Njengoba i-cannabis iyi-schedule I elawula into e-United States, ezinye izindlela zokwenziwa kwe-CBD zihlala zingekho emthethweni ukunquma ukusetshenziswa kwezokwelapha noma ukusebenzisa njengesithako ekudleni noma kwezithasiselo zokudla.