I-cytoskeleton iyinethiwekhi eyinkimbinkimbi, enamandla yokuxhuma amaprotheni amafilimu akhona ku-cytoplasm yawo wonke amaseli, kufaka phakathi amabhaktheriya ne-archaea. Isuka ku-nucleus yeseli iye kolwelwesi lweseli futhi yakhiwe ngamaprotheni afanayo ezilwaneni ezahlukahlukene. Kuma-eukaryote, yakhiwa ngezinto ezintathu eziyinhloko, ama-microfilaments, imicu emaphakathi kanye nama-microtubules, futhi konke lokhu kungakwazi ukukhula ngokushesha noma ukuqaqa kuncike kuzidingo zeseli.