UPixley ka Isaka Seme (c. 1881 [1] - Juni 1951) wayengomunye wabameli abamnyama baseNingizimu Afrika (u-Alfred Mangena wayengummeli wokuqala omnyama, uDuma Nokwe ummeli wokuqala omnyama), kanye nomsunguli noMongameli Wama-Afrika I-National Congress.