I-cytoplasm (eyaziwa nangokuthi i-cytosol) yi-protoplasm yeseli engaphandle kwe-nucleus yeseli. Kuyinto efana ne-jelly kanye nama-organelles ngaphandle kwe-nucleus, nangaphakathi kolwelwesi lweseli. Imisebenzi eminingi ebalulekile yeseli yenzeka kuma-organelles, afana nezinsimbi zemishini yokwenza imisebenzi eminingi. Icytoplasm yakhiwe kahle: ayilona uhlobo lwesobho, noma ngabe yenziwa ngamanzi angama-75-80%. I-cytosol iqukethe ingxube eyinkimbinkimbi yemicu ye-cytoskeleton, kufaka phakathi i-endoplasmic reticulum kanye nezinto zikaGolgi. Kubandakanya ama-molecule ancibilikisiwe, namanzi agcwalisa ingxenye enkulu yengqamuzana. Ngenxa yale nethiwekhi yemicu, ulwelwesi nama-macromolecule amaningi ancibilikile njengamaprotheni, i-cytosol ayisebenzi njengoketshezi olulula. Umsebenzi oyinhloko we-cytoplasm ukubamba ama-organelles endaweni.