Ezilwaneni ezincelisayo, isitho sangasese sowesifazane siyingxenye yokunwebeka, yemisipha yegciwane lesitho sangasese sowesifazane. Kubantu, isuka esithweni sangasese iye emgodleni wesibeletho. Ukuvuleka kwangaphandle kwesitho sangasese sowesifazane kuvame ukumbozwa ingxenye ethile yensumpa. Ekugcineni okujulile, umlomo wesibeletho (intamo yesibeletho) ungena ngaphakathi esithweni sangasese. Isitho sangasese sivumela ukuya ocansini nokuzalwa. Ibuye ihambise ukugeleza kokuya esikhathini (menses), okwenzeka kubantu nasezimpungwini ezihlobene eduze njengengxenye yomjikelezo wokuya esikhathini nyangazonke. i-anatomy ephelele Isitho sowesifazane sangasese somuntu siwumsele onwetshiwe, onemisipha osukela esithweni sangasese somlomo wesitho sangasese sowesifazane uze uye emlonyeni wesibeletho.Ukuvulwa kwesitho sangasese sowesifazane kulele kunxantathu wesibeleko. Unxantathu we-urogenital unxantathu ongaphambili we-perineum futhi uqukethe ukuvuleka komchamo nezingxenye ezihambisanayo zesitho sangasese sangasese. Eduze kwesitho sangasese sangaphezulu, umlomo wesibeletho uphumela ngaphakathi esithweni sangasese sangaphambi kobuso bawo cishe nge-engela engu-90 degree. Ukuvuleka kwesitho sangasese sowesifazane kanye nokuchama kuvikelwe ilebhu. Uma ungavuswanga ngokocansi, isitho sangasese siyishubhu ewile, kubekwe izindonga zangaphambili nezingemuva ndawonye. Izindonga eziseceleni, ikakhulukazi indawo yazo emaphakathi, ziqinile kakhulu.