Ukuhlolwa kwesifo kusho ukuthola ukuthi yisiphi isifo esihambiselana nezimpawu ezitholakala esigulini. Kuvamise ukubizwa ngokuxilonga kusetshenziswa ulimi lwezokwelapha olucacile. Ulwazi oludingekayo uma kuxilongwa luvamise ukuthi lutholakale emlandweni kanye nasekuhlolweni komzimba waloyo odinga usizo lokwelashwa. Kujwayelekile ukuthi kusetshenziswe izindlela zokuthola isifo eziningi uma kuhlolwa, kubalwa kuzo ukuhlolwa ngezokwelapha. Kwesinye isikhathi ukuxilongwa ngemuva kokufa nakho kuthathwa njengokuxilonga okuhambelana nezokwelapha. Lokhu kuxilonga kuvamise ukubanezingqinamba, ngoba iningi lezimpawu azicaci kahle. Isibonelo ukubabomvu kwesikhumba, nokungaba uphawu lwezifo ezahlukene ngakho ke okumcaciseli umsebenzi wezempilo ukuthi ngabe inkinga ikuphi. Izindlela ezijwayelekile ezikhona ezindleleni ezahlukene kwinqubo yokuxilonga zifaka lokhu: Ukuqoqa eminye imniningwano ngeziguli, okungafaka imibuzo ngomlando wezempilo ( ikakhulukazi owabantu abasondelene nesiguli), ukuxilongwa kwesiguli nezinye izindlela zokuhlola izifo. Ukuxilonga uhlobo lokuhlola lwezokwelapha olwenziwa njengosizo lokubheka noma ukutholwa kwesifo. Ukuxilonga kungaphinde kusetshenziselwe ukuthola imniningwane yokuqonda abantu abanesifo esesitholakele. Ukucutshungulwa kwezimpendulo, okutholakele noma eminye imiphumela. Ukuzama ukubonana nabanye abahlinzeki nochwepheshe kulomkhakha. Kunezindlela eziningi noma amasu angasetshenziswa enqutshweni yokuxilonga, nesingabala kuwo ukusebenzisa izindlela ezahlukene zokuhlola, noma ukulandela imithetho eqondile yokwezokwelapha. Empeleni inqubo yokuxilonga ingahlanganisa noma isebenzise izindlela eziningi ezahlukene. Ukutheleleka ngesifo sekhorona i-COVID-19 kungaxilongwa okwesikhashana ngokubheka izimpawu yize isiqiniseko sitholakala ngokwenza i-Reverse transcription polymer chain reaction (rRT-PCR) lapho kusetshenziswa uketshezi oluthelelekile noma i- CT imaging.