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During the COVID-19 pandemic, research on "cytokine storms" has been reinvigorated in the field of infectious disease, but it also has particular relevance to cancer research. | Authentic |
Our data showed that the expression of NOX4 was upregulated in human neuroblastoma cells SH-SY5Y under hypoxia condition time dependently. | Counterfeit |
This study aims to elucidate the effects of long non-coding RNA LINC01260 (LINC01260) on the proliferation, migration and invasion of spinal cord glioma cells by targeting Caspase recruitment domain family, member 11 (CARD11) via nuclear factor kappa B (NF-κB) signaling. | Counterfeit |
Balancing a changed life situation: the lived experience from next of kin to persons with inoperable lung cancer. | Authentic |
Cardiovascular diseases are closely associated with a high-cholesterol or high-fat diet. | Counterfeit |
KLF7 Promotes Gastric Carcinogenesis Through Regulation of ANTXR1. | Counterfeit |
The present study aimed to investigate the function of HOTAIR in lymphoma and its underlying mechanisms. | Counterfeit |
Our study indicates that CASC15 could promote metastasis and proliferation of NSCLC through sponging miR-130b-3p in vitro and in vivo, which may offer a new therapeutic intervention for NSCLC patients. | Counterfeit |
However, its underlying molecular mechanism in NSCLC is still unclear. | Counterfeit |
was not obtained (p = .420). | Authentic |
DJ-1-phosphate and tension homology deleted on chromosome ten/phosphatidylinositol-3-kinase/protein kinase B (PTEN/PI3K/AKT) signaling pathway plays a role in the regulation of ischemic reperfusion (I-R) injury. | Counterfeit |
In contrast to mouse adenocarcinomas, the LP tumors contained immune populations enriched for tumor-associated neutrophils. | Authentic |
Drug-resistance remains a huge problem in the therapy of malignant tumors including non-small cell lung cancer (NSCLC). | Counterfeit |
The purpose of our study was to investigate the anti-proliferative effects of hinokitiol on EC cells. | Authentic |
LncARSR was observed to bind to YAP1, which inhibited phosphorylation nuclear translocation. | Counterfeit |
In the 5 participants with previously identified cancers, no recurrence or metastasis was detected.The offer of whole-body FDG-PET for cancer screening was welcomed with enthusiasm by most of the hospital employees. | Authentic |
However, the level of methyl phosphate, which was decreased in muscle in cancer, was restored by sACVR2B-Fc treatment. | Authentic |
Meanwhile, college students with mothers of different educational levels have significant differences in the scores of various dimensions of the mother's rearing style. | Counterfeit |
Despite multiple developments in medical and surgical treatments, GBM is still a deadly disease with a high mortality rate. | Counterfeit |
After 48/72 hours of transfection, cell proliferation in microRNA-126-MG63 group was significantly reduced compared to blank group (both P < .05). | Counterfeit |
Dual luciferase reporter assay validated the direct regulation between miR-16 and MEK1. | Counterfeit |
From 242 studies, 34 cohort studies were included in our meta-analysis. | Authentic |
The purpose of this study is to explore the mechanism of XMT in alleviating secondary damage in the ischemic area after ICH. | Counterfeit |
The research results believe that, from the perspective of rights, environmental rights should be regarded as the concentrated expression of rights in the sense of private law in the ecological environment law. | Counterfeit |
Heightened miR-216b expression was found to be positively correlated with patient survival, and miR-216b further enhanced cisplatin-induced apoptosis of MG63 and SaOS-2 cells. | Counterfeit |
In this research, LINC00152 was proven to have a higher expression level in GC tissues than in the adjacent normal tissues. | Counterfeit |
CD40 is a potential marker of favorable prognosis in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. | Authentic |
The neonatal rat models of HIBD presented impaired neurobehaviors and antioxidant capacity, increased neuronal apoptosis and expression of HIF-1α and histone deacetylase 1 (HDAC1), as well as diminished expression of neurotrophic factors and K+ -Cl- -cotransporter 2 (KCC2). | Counterfeit |
Enbrel® (30 mg/kg, intraperitoneally (i.p.)) | Authentic |
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy. | Authentic |
TRIM27 directly polyubiquitinates ULK1 at K568 and K571 sites with K48-linked ubiquitin chains, with proteasomal turnover maintaining control over basal ULK1 levels. | Authentic |
Moreover, RCC cell proliferation was inhibited and cell apoptosis was promoted after knockdown of SNHG7 in vitro. | Counterfeit |
qRT-PCR was employed for the evaluation of the expressions of miR-495 and Stat3, while receiver operating characteristic (ROC) curve was constructed to assess the predictive value of miR-495 and Stat3 as well as the treatment outcomes of patients with lower limb fractures. | Counterfeit |
It was noted that miR-448 targeted and downregulated MAGEA6, thus activating the AMP-activated protein kinase (AMPK) signaling pathway in HCC. | Counterfeit |
Cell survival rate was declined at 6 and 8 Gy of X-ray irradiation compared with 0, 2 and 4 Gy. | Counterfeit |
Following transfection, DPSCs were divided into blank, control, miR-143-5p mimics, miR-143-5p inhibitors, miR-143-5p inhibitors + siRunx2 and siRunx2 groups. | Counterfeit |
We found that TPL significantly inhibited the viability, proliferation, and migration of Daoy cells but promoted Daoy cell apoptosis. | Counterfeit |
This research discloses the influence of PEG10 in the biological actions of malignant melanoma cells. | Counterfeit |
Correlation between expression levels of PAPAS and miRNA-188-5p in GC tissues was explored. | Counterfeit |
We showed that treatment with a benzimidazole derivative bearing a pyrrolidine side chain (compound 9a) inhibited the proliferation of SR cells by blocking the phosphorylation of AKT, p70S6 and the downstream molecule RPS6. | Authentic |
This study aims to figure out the methylation of long non-coding RNA GAS5 promoter in cervical cancer and the mechanism of GAS5 on the progression of cervical cancer cells. | Counterfeit |
MEG3 overexpression enhanced hypoxia injuries, while MEG3 suppression attenuated the injuries. | Counterfeit |
Confirming or rejecting associations of maternal smoking with lymphoma and the five other cancer types requires further studies. | Authentic |
Herein, the study aimed to investigate the effects of serum exosomal miR-137 on oxidative stress injury of neurons in PD. | Counterfeit |
TINCR and ROCK1 overexpression led to increased rate of cancer cell proliferation, while miR-214-5p played an opposite role and reduced the effects of TINCR overexpression. | Counterfeit |
Zurampic is a US FDA approved drug for treatment of gout. | Counterfeit |
Janus kinase (JAK) - signal transducer and activator of transcription (STAT) signal pathway participates in regulating cell proliferation, differentiation, and apoptosis, and is correlated with non-small cell lung cancer (NSCLC) onset. | Counterfeit |
The aim of this study was to estimate prognostic significance of TSR in gastric adenocarcinoma. | Authentic |
Diabetic mice were transfused with improved or standard autologous blood in perfusion culture system. | Counterfeit |
PD-1+ TIL indeed exhibit a continuum of exhaustion states, with variable levels of CD28 costimulation, which is provided by antigen-presenting cells (APC) in intraepithelial tumor myeloid niches. | Authentic |
RT-PCR was used to detect mRNA expression of IL-37 and ELISA to determine IL-37 and MMP-9 expressions. | Counterfeit |
Real-time PCR was used to detect GAS5 and microRNA-137 (miR-137) expression in the brain tissues of mice underwent middle cerebral artery occlusion (MCAO) surgery and oxygen-glucose deprivation (OGD)-treated mouse primary brain neurons. | Counterfeit |
Preexisting Somatic Mutations of Estrogen Receptor Alpha (ESR1) in Early-Stage Primary Breast Cancer. | Authentic |
qRT-PCR indicated that LINC00312 expression was lower but miR-197-3p expression was higher in BC tissues compared with adjacent tissues; LINC00312 was negatively correlated with miR-197-3p. | Counterfeit |
We firstly selected differentially expressed lncRNAs and genes by the Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO). | Counterfeit |
To solve this problem, we fabricate cationic IR-780-loaded liposomes (ILs) by entrapping IR-780 within the lipid bilayer of liposomes. | Authentic |
Biochem. | Counterfeit |
This approach has been largely overlooked, resulting in a gap between the potential of ACT and its actual effectiveness. | Authentic |
Therefore, the present study aimed to investigate the effects of miR-215 in NSCLC tumorigenesis and development. | Counterfeit |
Cell survival and apoptosis rate were detected by colony formation assay and flow cytometry, respectively. | Counterfeit |
Next, a series of gain- and loss-of function experiments were conducted to determine the role of miR-26a in angiogenesis of human brain microvascular endothelial cells (HBMECs). | Counterfeit |
The correlation between the expression of SNHG3 and miR‑326 was found to be strongly negative in these samples. | Counterfeit |
The relationship between miR-21 and SPRY1 was identified using dual-luciferase reporter assay. | Counterfeit |
The levels of miR-151-3p in several NPC cell lines were detected in order to screen an experimental cell line. | Counterfeit |
The incidence of fever is high in hospitalised patients with AGA. | Counterfeit |
NFAT5 overexpression aggravated HG-induced fibrosis by stimulating AKT phosphorylation. | Counterfeit |
To determine the effect of HOTAIR silence or overexpression in inflammation, we applied quantitative reverse-transcription polymerase chain reaction, immunoblotting assay, and enzyme-linked immuno sorbent assay. | Counterfeit |
Meanwhile, extracellular matrix (ECM)-related proteins were detected by Western blot analysis. | Counterfeit |
Monensin is a potent inducer of oxidative stress and inhibitor of androgen signaling leading to apoptosis in prostate cancer cells. | Authentic |
Besides, baicalin enhanced hypoxia-caused activation of Nrf2/HO-1 pathway. | Counterfeit |
However, the role of WNT ligands in RCC has not yet been determined. | Authentic |
The messenger RNA (mRNA) and protein expression of PAI-1 and vascular endothelial growth factor (VEGF) were determined by reverse transcription quantitative polymerase chain reaction and Western blot analysis. | Counterfeit |
Knockdown of NFIC significantly inhibited the viability, colony formation, invasion, and migration of gastric cancer cells. | Counterfeit |
Propofol Inhibits Lung Cancer A549 Cell Growth and Epithelial-Mesenchymal Transition Process by Upregulation of MicroRNA-1284. | Counterfeit |
Eighty-one cases of PP were visited between January 2021 and March 2021, and their direct relatives were selected as the research population for retrospective analysis. | Counterfeit |
There are a large number of concepts and theories that explain certain aspects of public opinion: exposure to influence, an impact on people's actions, and its contradictory nature. | Counterfeit |
These results establish a global hijacking mechanism for SS18-SSX on chromatin, and define the distinct contributions of two concurrent BAF complex perturbations. | Authentic |
The potential usage of curcumin in diverse human diseases has been widely studied, including arteriosclerosis (AS). | Counterfeit |
The aim of this study was to explore cancer survivors' experienced outcomes of a multidimensional rehabilitation program in primary healthcare. | Authentic |
From the aforementioned findings, we concluded that PRLR gene silencing results in the inhibition of hippocampal neuron apoptosis and alleviation of CMS-induced depression by inactivating the JAK2-STAT5 signaling pathway and elevating BDNF expression, providing a new insight for the treatment of depression. | Counterfeit |
Silenced circ-RANGAP1 boosts MYLIP expression via competitive binding of miR-542-3p to facilitate OS cell progression. | Counterfeit |
Dual-Luciferase reporter gene assay was conducted to verify the binding of circHIPK3 to miRNA-124-3p. | Counterfeit |
We also examined miR-4324 expression in CRC tumor tissues using a miRNA expression dataset obtained from the Gene Expression Omnibus. | Counterfeit |
PET parameters with significant impact on progression-free survival (PFS) in receiver operating characteristic curves and univariate Cox models were identified and included in recursive partitioning analysis (RPA) for constructing a prognostic model. | Authentic |
Logistic regression analyses were used to evaluate the variables associated with ovarian cancer. | Authentic |
lncRNA-UCA1 functioned as an endogenous sponge of miR-193a. | Counterfeit |
CRP was seen to be an independent predictor of cancer-specific survival but not overall survival in uni- and multivariable (HR 1.01 (1.00-1.02); p = 0.028) analyses of non-irradiated patients. | Authentic |
Moreover, TC cell proliferation was inhibited, and TC cell apoptosis was induced after SNHG7 was knocked down in vitro. | Counterfeit |
The study aimed to explore the effect of miR-206 on lipopolysaccharide (LPS)-induced inflammation injury in MRC-5 cells, and point out a potential relevance for chronic obstructive pulmonary disease (COPD). | Counterfeit |
Then, effects of miR-675 overexpression on AP-treated cells were analyzed. | Counterfeit |
Compared with younger patients, a significant enrichment of TET2 and SRSF2 was observed, together with a reduced frequency of DNMT3A mutations. | Authentic |
The Canadian prediction model was first externally validated exactly as published. | Authentic |
This study examines the semantic expression of words, the NN model for common sense reasoning, the method of building a common sense knowledge base, and the translation of Japanese literary language with an emphasis on the semantic expression and reasoning methods of natural language based on NN. | Counterfeit |
The functional roles of EV-derived miR-410 were determined using loss- and gain-of functions experiments, and by evaluating neuronal viability, cell-cycle distribution and neuronal apoptosis in vitro as well as modified neurological severity score (mNSS), edema formation, and cerebral infarction volume in vivo. | Counterfeit |
The proapoptotic Xbp1s role in FOB cells starkly contrasts with its antithetical prosurvival function in plasma cells. | Authentic |
However, the molecular regulation following by Ras-ERK1/2 activation is still unclear. | Counterfeit |
In this study, we aim to explore the possible involvement of lncRNA 'cyclin-dependent kinase inhibitor 2B antisense noncoding RNA' (CDKN2B-AS1) and CDKN2B in the progression of atherosclerosis. | Counterfeit |
Oral squamous cell carcinoma (OSCC) is a major health problem in many parts of the world, and the major causative agents are thought to be the use of alcohol and tobacco. | Authentic |
We included 33 (57.9%) boys and 24 (42.1%) girls, aged a median 38 days (range, 2-135 days). | Counterfeit |
Compared with the blank, NC and miR-146a inhibitor + si-TRAF6 groups, the mRNA and protein expressions of TRAF6 and NF-κB decreased, cell proliferation rate increased and cell apoptosis rate decreased in the miR-146a mimics and si-TRAF6 groups, while opposite trends were observed in the miR-146a inhibitors group. | Counterfeit |