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Primary neonatal rat ventricular cardiomyocytes (PNCM) were isolated from neonate rat pups. | Counterfeit |
Reverse transcription‑quantitative polymerase chain reaction and western blot analysis were used to examine the mRNA and protein expression levels. | Counterfeit |
Pre-operative anaemia has been related to adverse outcomes after surgical management of colorectal cancer. | Authentic |
This study designed to see the function of the lncRNA ANRIL in retinoblastoma Y79 cells. | Counterfeit |
Univariate analyses showed that patients with NLR ≥3 had significantly worse 2-year DFS and 5-year OS rates. | Authentic |
Median survival of patients with low expression of miR-486 (30 months) was shorter than the patients with higher expression of miR‑486 (40 months). | Counterfeit |
Total mutation rate of N-Ras, BRAF and K-Ras in case group were 5.2%, 12.2% and 47.4%, respectively. | Counterfeit |
These findings provide a theoretical basis for the treatment of flunarizine hydrochloride in ICH. | Counterfeit |
MiR-31 negatively regulates the noncanonical NF-κB pathway by targeting NF-κB inducing kinase (NIK). | Authentic |
Furthermore, the in vitro findings were reproduced in the in vivo experiments. | Counterfeit |
AS-IV induced caspase-dependent apoptosis, which involved the increased release of cytochrome c and Omi from the mitochondria into the cytoplasm and the up-regulation of Bax/Bcl-2 ratio, as well as the activation of PARP and caspase cascade (caspase-3 and -9). | Counterfeit |
TUNEL staining was conducted to detect neuronal apoptosis in the hippocampal CA1 region. | Counterfeit |
Long noncoding RNA TUG1 promotes progression via upregulating DGCR8 in prostate cancer. | Counterfeit |
If these results are generalizable to an unselected patient population treated in clinical routine is unknown. | Authentic |
Safety and toxicology were assessed by monitoring the clinical status of the animals and by histological, hematological, and clinical chemistry parameters. | Authentic |
Immunohistochemical and TUNEL staining techniques were employed to evaluate the positive expression rates of the protein CREB1 and Cleaved Caspase-3, as well as neuronal apoptosis among hippocampal tissues in a respective manner. | Counterfeit |
Pancreatic cancer (PC) cells-derived exosomes could mediate angiogenesis of human microvascular endothelial cells (HUVECs) in PC. | Counterfeit |
Expression of miR-21 in cells treated with hypoxia or hypoxia plus GSTD was determined by stem-loop RT-PCR. | Counterfeit |
Furthermore, the regulatory mechanism between SNHG6 and miR-101 as well as between SNHG6 and activation of Wnt/β-catenin pathway was investigated. | Counterfeit |
Both mutations define clinically and biologically distinct subgroups of pHGGs. | Authentic |
In the research of this paper, through the combination of theory and practice, the enterprise's emotional management work has been comprehensively analyzed, and the practical problems existing in its emotional management work have been found through questionnaires. | Counterfeit |
Results: In our present work, we observed that the cell viability was promoted by 6 G in the hypoxia-induced H9c2 cells in a dose-dependent manner. | Counterfeit |
AIF inhibited ESCC cell viability and suppressed cell growth in a dose- and time-dependent fashion. | Counterfeit |
A radical surgical result at metastasectomy was achieved in 46 of 97 patients (47%). | Authentic |
The microarray dataset GSE63939 showed that miR-31-5p and AXIN1 were involved in OS. | Counterfeit |
qRT PCR and Western blot analysis of LNA-anti-miR-200c transfected cells revealed a considerable increase in CSCs markers, vimentin, ZEB-1, N-cadherin, and β-catenin expression, with a concomitant reduction in E-cadherin expression level. | Counterfeit |
Indirect co-culture with visfatin-treated THP-1 (V-THP-1) promoted the viability, migration, tumorsphere formation, EMT, and stemness of breast cancer cells. | Authentic |
Mice deficient for IL-18 were remarkably protected from Vk∗MYC MM progression in a CD8+ T cell-dependent manner. | Authentic |
The combination of multiple molecular targeted agents or the use of multi-target agents may enhance the efficacy at the expense of increased toxicities. | Authentic |
Forty-five effusions were additionally studied using Western blotting. | Authentic |
Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo. | Authentic |
In this study, the derivatization and dual targeted delivery technologies were used to actively transport antioxidant melatonin (MLT) into the mitochondria of oxidative stress-damaged cells in brain tissues. | Counterfeit |
Finally, reduced expression of TKT and CTPS, which regulate flux into pyrimidine biosynthesis, correlates with better prognosis in pancreatic cancer patients on fluoropyrimidine analogs. | Authentic |
Knee injury is known as a frequently occurred damage related to sports, which may affect the function of cartilage. | Counterfeit |
However, its role in gastric cancer remains unknown. | Counterfeit |
We identify that an obligate L-lactate-producing lactic acid bacterium found in tumors, Lactobacillus iners, is associated with decreased survival in patients, induces chemotherapy and radiation resistance in cervical cancer cells, and leads to metabolic rewiring, or alterations in multiple metabolic pathways, in tumors. | Authentic |
Similar to previous studies, we analyzed bladder cancer patients treated with and without BCG therapy. | Authentic |
Patients were divided into group 1 (n = 41) with hemi-/extended hepatectomies, and group 2 (n = 63) with central hepatectomies. | Authentic |
Metastatic potential peaks in rare, late-hybrid EMT states, which are aggressively selected from a predominately epithelial ancestral pool. | Authentic |
The endpoints were overall survival (O.S. | Authentic |
Alpinumisoflavone triggers GSDME-dependent pyroptosis in esophageal squamous cell carcinomas. | Counterfeit |
Cells transfected with shCCNB1 had lower expressions of CCNB1 and MDM2, whereas higher expressions of Bax, caspase-9, caspase-3, p53, and p21. | Counterfeit |
In 39 of 42 samples, metastatic lymph nodes were located in the mesorectum, and 13 of 42 samples also had metastatic lymph nodes in the sigmoid mesentery. | Authentic |
Overexpression of miR-128-3p was found to inhibit proliferation, migration, invasion, self-renewal in vitro and tumorigenicity in vivo of BCSCs, which was further validated to be achieved through inhibition of Wnt signalling pathway by down-regulating NEK2. | Counterfeit |
Systemic inflammatory response in colorectal cancer (CRC) has been established as a prognostic factor for impaired cancer-specific survival, predominantly in patients with right-sided tumors. | Authentic |
Radiotherapy planning CT's and treatment plans were reviewed, and recurrences were mapped and categorized according to radiation dose. | Authentic |
Transforming growth factor beta 1 levels predict echocardiographic changes at three years after adjuvant radiotherapy for breast cancer. | Authentic |
Prescription drug purchases information was obtained from the national reimbursement database. | Authentic |
SHH mRNA and protein expressions were greater in the SHH-RNAi group than in the blank and NC groups. | Counterfeit |
Overexpression of miR-196b suppressed cell viability, migration, invasion, and induced apoptosis as well as inhibited TGF-β induced EMT process in A549 cells. | Counterfeit |
Functionally, TRG-AS1 depletion suppressed TSCC cell proliferation, migration, and invasion in vitro; promoted cell apoptosis; and attenuated tumor growth in vivo. | Counterfeit |
A retrospective cohort study of all patients treated for a new diagnosis of HNC at the Department of Otorhinolaryngology and Head and Neck Surgery at Karolinska University Hospital between January 1, 2000 and December 31, 2018 in whom gastrostomy was performed. | Authentic |
Increased incidence of ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC) after introduction of organized screening has prompted debate about overdiagnosis. | Authentic |
Treatment for T1-2 oral squamous cell carcinoma with or without perineural invasion: neck dissection and postoperative adjuvant therapy. | Authentic |
Our study provided evidence that miR-224 could alleviate the occurrence and development of ALEXI in mice through activation of the mTOR signaling pathway by downregulating CHOP. | Counterfeit |
The results indicated that miR-143 inhibits cell migration and invasion in DU145 and PC-3 cells. | Counterfeit |
Fallout of 137Cs was retrieved as a digital map from the Geological Survey of Sweden, demographic data from Statistics Sweden, and cancer diagnosis from the National Board of Health and Welfare. | Authentic |
The FT multimodal programmes may enhance the postoperative recovery by means of reducing surgical stress. | Authentic |
Verification of the targeting relationship between miR-192-5p and Fbln2 was provided in the form of initial bioinformatics prediction, followed by a further verification in the form of a dual-luciferase reporter gene assay. | Counterfeit |
NQO1 protein expression and NFκB activation showed only trends, but no statistical significance for patient survival or outcome after anthracycline treatment. | Authentic |
Meanwhile, our results also showed that AIF triggered pyroptotic cell death in ESCC, which was mediated by gasdermin E (GSDME) cleavage. | Counterfeit |
The transplanted tumors in mice with down-regulated miR-144 exhibited a lower mean tumor diameter and weight, and increased apoptosis index and expression of AKAP12 and ERK1/2. | Counterfeit |
Anillin (ANLN), as a type of evolutionarily conserved actin-binding protein, is involved in multiple cellular processes. | Counterfeit |
The results of our study suggest that miR-142 inhibits proliferation and promotes apoptosis in ASMCs during airway remodeling in asthmatic rats by inhibiting TGF-β expression via a mechanism involving the EGFR signaling pathway. | Counterfeit |
In vitro wound healing assay and matrigel assay were carried out to study the effects of angustifoline on cell migration and cell invasion respectively. | Counterfeit |
The tumor-associated isocitrate dehydrogenase (IDH) mutants are unique in that they have lost their normal catalytic activity and gained a novel function to produce R-2-hydroxyglutarate (R-2-HG). | Authentic |
We identified gig (fly TSC2) and found that inactivation of rbf (fly Rb) and gig synergistically induced cell death. | Authentic |
Therefore, this study provides a candidate therapeutic target for RA. | Counterfeit |
Compared to normal embryonic pituitary cells, the level of miR-16 was decreased, while the expressions of p-ERK1/2, Survivin, and Cyclin D1, along with cell proliferation or S or G2/M phase ratio were up-regulated in the group of HP75 cells. | Counterfeit |
Therefore, we consider that miR-365 acts as a tumor suppressor in OS, partly, by targeting CYR61 expression. | Counterfeit |
The expression of E-cadherin, N-cadherin, and phosphorylated p38MAPK (p-p38MAPK) proteins was determined by Western blot. | Counterfeit |
Functional assay revealed that CTGF significantly decreased the CRC cell adhesion ability, and integrin α5 was confirmed by reverse transcriptase PCR and functional blocking assay as a downstream effector in the CTGF-mediated inhibition of CRC cell adhesion. | Authentic |
In addition, 2DG-PEG-AuD successfully demonstrated significant augmentation of CT contrast in both in vitro cell studies and in vivo tumor-bearing mouse models. | Authentic |
Caspase-2 is ubiquitously expressed and the most evolutionarily conserved mammalian caspase. | Authentic |
Neoadjuvant chemotherapy seemed to result in a relocation of Th1-committed CD4+ T cells from blood, presumably to the tumour, indicated by shifts in the methylation patterns, whereas no such shifts were seen for lineages corresponding to IL13, IL17A and FOXP3. | Authentic |
To report the outcomes of salvage robot-assisted radical prostatectomy (S-RaRP). | Authentic |
We investigated the effects of recombinant LZ-8 protein (rLZ-8) on the proliferation of A549 human lung cancer cells. | Authentic |
High CD44 and Id1 levels confer poor prognosis in GBM patients. | Authentic |
Here, we report the identification of PTENε (also named as PTEN5), a novel N-terminal-extended PTEN isoform that suppresses tumor invasion and metastasis. | Authentic |
Dammarenediol suppresses the growth, migration and invasion of human osteosarcoma cells by modulating PI3K/Akt and STAT-3 signaling pathways. | Counterfeit |
Furthermore, the underlying mechanism was explored by using qRT-PCR and Western blot assay. | Counterfeit |
We evaluated the safety, toxicology, and biodistribution of intravenous AdsVEGFR-2 and AdsVEGFR-3 combined with chemotherapy in healthy rats (n=90) before entering a clinical setting. | Authentic |
To date, several onco-microRNAs (miRNAs or miRs), including miR-96, have been identified in the pathogenesis of CRC. | Counterfeit |
Our findings highlighted the potential of lncRNA AGAP2-AS1 as a promising novel molecular target for prostate cancer therapy. | Counterfeit |
We aimed to detect the effects of miR-145-5p on the cell proliferation, apoptosis, migration, and invasion in NRAS-mutant, BRAF-mutant, and wild-type melanoma cells, in order to figure out the potential mechanisms and provide a novel therapeutic target of melanoma. | Counterfeit |
Differentially expressed genes related to ESCC were identified from microarray gene expression profiles. | Counterfeit |
The GDM mice were treated with miR-222 Antagomir/Agomir or overexpressed CXCR4 to evaluate the apoptosis and pathological changes in tissues, and the levels of blood glucose, insulin, biochemical indices, inflammatory factors and inflammasome-related proteins. | Counterfeit |
Collectively, this study revealed that PTPN family members are both significant prognostic biomarkers for lung cancer progression and promising clinical therapeutic targets, which provide new targets for treating LUAD patients. | Authentic |
Therefore, the lncRNA NEAT1 may be used as a molecular potential for the diagnosis and treatment of cervical cancer through regulating AKT/PI3K signaling pathway, which would be confirmed in the following study. | Counterfeit |
A cluster of LAMP3+ dendritic cells (DCs) appeared to be the mature form of conventional DCs and possessed the potential to migrate from tumors to LNs. | Authentic |
The study revealed a total of 27 design issues (13 for mobile apps and 14 for tablet apps), which were mapped to source events (ie, errors, requests for help, participants' concurrent feedback, and moderator observation). | Authentic |
The antioxidants and inactivation of KRAS also inhibited OA-induced EMT and metastasis. | Authentic |
Moreover, miR-135b could promote the expression of phosphorylated AKT and phosphorylated mTOR in the AKT/mTOR pathway. | Counterfeit |
The targeting relationship between miR-320 and CYP1A2 was verified by bioinformatics website and dual luciferase reporter gene assay. | Counterfeit |
Mouse models with endometriosis were established and grouped. | Counterfeit |
Compared with the control group, there were more leukocytes, increased EOS and LYM proportions, higher Underwood and PAS scores, increased WTt, WTm, WAt/A0, WAm/WAt, WTt/R0, WTm/WTt, TSLP, OX40L, a-SMA and collagen I mRNA and protein levels, and higher SLP, OX40L, IL-4, IL-5 and IL-13 levels, but lower MON proportions and IFN-γ levels in the asthma and IgG2a mAb groups. | Counterfeit |
OGD-induced injury was significantly attenuated by pioglitazone at the concentration of 5 μM. | Counterfeit |
The acquired list-mode data were resampled to produce data sets with shorter acquisition times of 41, 38, 32, 26, 20, and 16 min, narrower energy windows of 10, 8, 6, and 4%, and a larger matrix size of 256 × 256. | Authentic |
Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway. | Authentic |
Microrna-139-5p inhibits epithelial-mesenchymal transition and fibrosis in post-menopausal women with interstitial cystitis by targeting LPAR4 via the PI3K/Akt signaling pathway. | Counterfeit |