Datasets:

bigbio

/

medal

like 0

[ { "id": "3301", "type": "PubMed abstract", "text": [ "glucose transporter deficiency syndrome glutds is a treatable metabolic HIVE caused by a mutation in the slca gene this mutation causes a compromised transport of glucose across the bloodbrain barrier the treatment of choice is KD with which most patients become seizurefree at the national centre for epilepsy we have since offered treatment with ketogenic diet kd and modified atkins diet mad to children with difficulttotreat epilepsy as we believe many children with glutds are unrecognized the aim of this study was to search for patients with glutds among those who had been NR reduction in seizure frequency to kd or mad of the children included were defined as responders among these were already diagnosed with glutds no mutations in the slca gene were detected in the remaining patients however the clinical features of these patients differed considerably from the patients diagnosed with glutds while out of patients with glutds became seizurefree with dietary treatment only out of the remaining patients were seizurefree with kd or mad treatment we therefore conclude that a seizure reduction of following dietary treatment is not a suitable criterion for identifying patients with glutds as these patients generally achieve complete seizure freedom shortly T3 diet initiation" ], "offsets": [ [ 0, 1290 ] ] } ]

[ { "id": "3302", "type": "abbreviation", "text": [ "KD" ], "offsets": [ [ 228, 230 ] ], "normalized": [ { "db_name": "medal", "db_id": "ketogenic diet" } ] } ]

[]

[]

[]

[ { "id": "3304", "type": "PubMed abstract", "text": [ "in a yearold epileptic male who had been treated for more than ten years with an average of mg diphenylhydantoin and mg PB daily severe SE occurred which could only be controlled with high doses of diphenylhydantoin and PB intravenously during this treatment a severe mainly motor polyneuropathy occurred acutely which was more pronounced in the distal parts of the legs and cerebellar PS were noted at the same time the neuropathy largely regressed during the following year whereas the cerebellar symptoms persisted there is evidence for direct toxic damage of IP SN due to diphenylhydantoin phenobarbitone in high doses inhibits Kd of diphenylhydantoin competively in this patient it very likely contributed towards the development of sever intoxication leading to neurological defects" ], "offsets": [ [ 0, 788 ] ] } ]

[ { "id": "3305", "type": "abbreviation", "text": [ "PB" ], "offsets": [ [ 220, 222 ] ], "normalized": [ { "db_name": "medal", "db_id": "phenobarbitone" } ] } ]

[]

[]

[]

[ { "id": "3307", "type": "PubMed abstract", "text": [ "evidence that canine spinal farfield and nearfield somatosensory evoked potentials resemble those recorded in humans and other species has been presented and the vulnerability of each component to varying depths of HAL anesthesia is reported lumbar spinal peak latencies are not affected by halothane dose but the N1 is significantly prolonged by rapid rates of stimulation elevated stimulus rates and halothane doses reduce lumbar spinal cord potential amplitudes early farfield cephalic components are refractory to HAL late farfield components and nearfield cortical potentials are substantially altered by increments in HAL dose both nearfield and farfield responses are more readily identified in vertexneck than vertexbrow derivations early farfield somatosensory evoked potentials recorded from vertex to neck together with lumbar spinal cord potentials may be the preferred monitoring technique when the use of halothane anesthesia is desired rapid rates of stimulation may facilitate earlier recognition of cord dysfunction but supplement rather than replace baseline recordings at slow CS- rates" ], "offsets": [ [ 0, 1105 ] ] } ]

[ { "id": "3308", "type": "abbreviation", "text": [ "N1" ], "offsets": [ [ 314, 316 ] ], "normalized": [ { "db_name": "medal", "db_id": "negative peak" } ] } ]

[]

[]

[]

[ { "id": "3310", "type": "PubMed abstract", "text": [ "PET studies were conducted on guinea pig atrial mACh m receptors with the allosteric modulators heptanebisdimethylphthalimidopropylammonium bromide cphth gallamine and alcuronium to determine whether these ligands are able to recognize a common accessory site the three modulators inhibited the negative inotropic response to carbachol in this tissue when used in combination cphth and gallamine or cphth and alcuronium gave DR that were either additive or underadditive in contrast the combinations of cphth or alcuronium with the competitive antagonists nmethylscopolamine or atropine yielded supraadditive DR the data could be reconciled with a MM involving a ternary complex between the receptor carbachol nmethylscopolamine or atropine acting at the orthosteric binding site and cphth alcuronium or gallamine acting at a common allosteric site with varying degrees of heterotropic cooperativity" ], "offsets": [ [ 0, 899 ] ] } ]

[ { "id": "3311", "type": "abbreviation", "text": [ "mACh" ], "offsets": [ [ 48, 52 ] ], "normalized": [ { "db_name": "medal", "db_id": "muscarinic acetylcholine" } ] } ]

[]

[]

[]

[ { "id": "3313", "type": "PubMed abstract", "text": [ "although there has been much research on the factors associated with breast density most studies did not include hispanic women or relied on semiquantitative methods of assessing density using data from the chicago breast health project which targeted hispanic women and assessed density quantitatively using fullfield digital mammography we assessed crosssectional associations of breast cancer risk factors with percentage of breast density between november and june hispanic women recruited from three CHCs in chicago illinois completed a health and lifestyle questionnaire had their height and weight measured and underwent screening mammography the average percentage of total breast area occupied by fibroglandular tissue was computed from each mammographic view associations of breast CA risk AF with percentage of breast density were assessed using multivariate linear regression analyses overall the mean percentage of breast density was in multivariate analysis older age was associated with lower density p and density was lower among PM than premenopausal women beta p body mass index was significantly inversely related to percentage of breast density p women currently taking hormone replacement therapy had a higher percentage of breast density beta p in premenopausal women cigarette sm had a marginally higher percentage of density beta p compared with nonsmokers but there was no relationship for PM women other breast cancer risk factors were not associated with density in summary breast density was strongly and inversely associated with age body mass index and menopausal status and positively associated with HRT use and cigarette smoking additional research focusing on relationships of other potentially modifiable factors with the extent of breast density is warranted to better understand the interindividual R2 in density among hispanic women" ], "offsets": [ [ 0, 1870 ] ] } ]

[ { "id": "3314", "type": "abbreviation", "text": [ "CHCs" ], "offsets": [ [ 505, 509 ] ], "normalized": [ { "db_name": "medal", "db_id": "community health centers" } ] } ]

[]

[]

[]

[ { "id": "3316", "type": "PubMed abstract", "text": [ "the effect of nitrogen as the CAD cad gas on the fragmentation of dipyridamole was investigated in the range of ev collision SE the results support the collision MM reported elsewhere that the degree of ion fragmentation increases with the increasing mass of the collision gas a simple CS and highthroughput liquid chromatographytandem mass spectrometry lcmsms method has been developed for the determination of dipyridamole a PLT aggregation inhibitor in HP using granisetron as internal standard is the method involved LLE of the analyte and is from ml human plasma with diethyl ether the chromatographic separation was achieved under isocratic conditions and the ion EMT for dipyridamole mz and the is mz were monitored on a triple quadrupole MS operating in PI multiple reaction monitoring mrm mode the method was validated over the concentration range ngml for dipyridamole the method was rugged and rapid with a total run time of min it was successfully applied to a pivotal bioequivalence T0 in healthy human subjects T3 oral administration of a mg extended PR formulation under fasting condition" ], "offsets": [ [ 0, 1103 ] ] } ]

[ { "id": "3317", "type": "abbreviation", "text": [ "MS" ], "offsets": [ [ 746, 748 ] ], "normalized": [ { "db_name": "medal", "db_id": "mass spectrometer" } ] } ]

[]

[]

[]

[ { "id": "3319", "type": "PubMed abstract", "text": [ "an interlaboratory T0 was conducted at locations to assess the stability of pesticides on SPE spe disks after incubation at various temperatures and for various time intervals deionized water fortified with selected pesticides was extracted by using types of spe filtration disks empore c and speedisk cxf and T3 SE the disks were incubated at temperatures and degrees c and for time intervals and days DW was fortified with atrazine carbofuran and chlorpyrifos by all participating laboratories in addition some of the laboratories included of the following pesticides metolachlor metribuzin simazine chlorothalonil and malathion concurrently fortified water samples were extracted with the incubated samples by using each disk type at and days pesticides had equivalent or greater stability on or of the c disk types compared with storage in water the lowest recoveries of carbofuran and chlorpyrifos were obtained at degrees c after storage for days in incubated water at degrees c after days the lowest REC for atrazine was obtained by using empore disks pesticidespecific losses occurred on the c disks in this study underlining the importance of temperature and time interval when water is extracted at remote field locations and the spe disks containing the extracted pesticides are transported or shipped to a laboratory for elution and analysis" ], "offsets": [ [ 0, 1353 ] ] } ]

[ { "id": "3320", "type": "abbreviation", "text": [ "DW" ], "offsets": [ [ 403, 405 ] ], "normalized": [ { "db_name": "medal", "db_id": "deionized water" } ] } ]

[]

[]

[]

[ { "id": "3322", "type": "PubMed abstract", "text": [ "biscarboxyethylandcarboxyfluorescein bcecf is frequently used for fluorometric determination of intracellular ph phi and its metabolic changes studies of bcecfloaded platelets have reported different phi values in the range of to despite the use of the same probe it is now shown that intracellular bcecf bcecfi content affects phi and that its overloading leads to significantly lower phi different phi values can be reproduced by changing bcecfi as reflected by FI the major loading AF are the concentration of the probe parent compound bcecf AM ester am and whether this ester is partly hydrolyzed externally when applied in plasma when least affected by bcecf PLT phi is high bcecfi does not affect atp content beta activation of nah exchange by protein kinase c pkc and basal pkc activity on the other hand high bcecfi does inhibit the nah exchange rate by over since the nah exchange strongly affects platelets phi it is proposed that this inhibition accounts at least partly for the lowered phi in bcecf overloaded platelets" ], "offsets": [ [ 0, 1031 ] ] } ]

[ { "id": "3323", "type": "abbreviation", "text": [ "AM" ], "offsets": [ [ 545, 547 ] ], "normalized": [ { "db_name": "medal", "db_id": "acetoxymethyl" } ] } ]

[]

[]

[]

[ { "id": "3325", "type": "PubMed abstract", "text": [ "the effects of c and c fatty acids on the synthesis of phosphatidylcholine were studied in apium graveolens cell suspension cultures and postmitochondrial supernatants when cells were exposed to exogenous OA the rate of phosphatidylcholine biosynthesis increased fold within min of the addition of the fatty acid to the SC medium the sensitivity of microsomal ctpcholinephosphate cytidylyltransferase ec to saturated and unsaturated fatty acids was monitored through the addition of free fatty acids to postmitochondrial S9 the saturated fatty acids palmitic and stearic appeared to have little effect on ctpcholinephosphate cytidylyltransferase activity whereas exposure to oleic linoleic and cisvaccenic acids resulted in significant increases in CEA optimal microsomal ctpcholinephosphate cytidylyltransferase MICs were achieved by the incubation of postmitochondrial S9 with microm oleate the exogenous fatty acids were found to be incorporated into microsomal membranes in their free form removal of unesterified fatty acids by incubation of microsomal CM with defatted bovine SS albumin resulted in the reduction of microsomal ctpcholinephosphate cytidylyltransferase activity demonstrating that the enzyme requires unesterified unsaturated fatty acids" ], "offsets": [ [ 0, 1258 ] ] } ]

[ { "id": "3326", "type": "abbreviation", "text": [ "free" ], "offsets": [ [ 984, 988 ] ], "normalized": [ { "db_name": "medal", "db_id": "unesterified" } ] } ]

[]

[]

[]

[ { "id": "3328", "type": "PubMed abstract", "text": [ "AP protein was demonstrated by immunostaining in all samples of ocular and conjunctival pseudoexfoliative psx material studied although amyloid was not found by congo red IF or ultrastructurally immunostaining of psx aggregates for other common amyloid proteins including amyloid a Pr and immunoglobulin CS chains was negative in most cases in three eyes with T3 neovascular glaucoma there was irregular immunostaining of the psx aggregates for of these other amyloid proteins besides diffuse IF of the iris and vitreous control cases of neovascular glaucoma without psx disease showed minimal AP but similar tissue staining for prealbumin and immunoglobulin CS chains consistent with an origin from V1 leakage the presence of amyloid p protein a minor SS component in psx aggregates in all cases with or without evidence of V1 leakage indicated a more TPS association ultrastructural localization of the protein on the periphery of psx SF suggest it is not an intrinsic fiber component since psx material has an immunological relation to elastic tissue we propose that psx SF have IP IB CS for amyloid p protein similar to those present on normal elastic fibers" ], "offsets": [ [ 0, 1162 ] ] } ]

[ { "id": "3329", "type": "abbreviation", "text": [ "AP" ], "offsets": [ [ 0, 2 ] ], "normalized": [ { "db_name": "medal", "db_id": "amyloid p" } ] } ]

[]

[]

[]

[ { "id": "3331", "type": "PubMed abstract", "text": [ "a puzzling aspect of middle ear surgery is the presence of an ABG in a small number of cases with no apparent cause we believe that some of these cases are due to unrecognized superior SC dehiscence sscd we have now gathered experience from patients with sscd presenting with apparent conductive hearing loss without vestibular symptoms all affected ears had sscd on highresolution ct scan the common findings in these patients were the airbone gaps occurred in the lower frequencies below hz and ranged from to db bone conduction thresholds below hz were sometimes negative db to db the acoustic stapedial reflex was present measurement of umbo velocity by laser dopplerumption the obtained experimental results showed that boron removal efficiency reached up to under optimum conditions in which solution ph was current density macm initial boron concentration mgl and solution temperature k the current density was an important parameter affecting energy consumption too high current density applied to electrocoagulation cell increased energy consumption increasing solution temperature caused to decrease SE consumption that high temperature decreased potential applied under constant current density that increasing initial boron concentration and dose of supporting electrolyte caused to increase TPS conductivity of solution decreased energy consumption as a result it was seen that energy consumption for boron removal via electrocoagulation method could be minimized at optimum conditions an empirical model was predicted by statistically experimentally obtained values were fitted with values predicted from empirical MM being as following formula in text unfortunately the conditions obtained for optimum boron removal were not the conditions obtained for minimum energy consumption it was determined that support electrolyte must be used for increase boron removal and decrease electrical energy consumption" ], "offsets": [ [ 0, 1920 ] ] } ]

[ { "id": "3332", "type": "abbreviation", "text": [ "ABG" ], "offsets": [ [ 62, 65 ] ], "normalized": [ { "db_name": "medal", "db_id": "airbone gap" } ] } ]

[]

[]

[]

[ { "id": "3334", "type": "PubMed abstract", "text": [ "SAA saa is a syndrome of severe bone marrow failure with high mortality our previous studies have demonstrated that both immature and G1 dc increased in the bone marrow of saa patients and the balance of dc subsets shifted the SD form to AS one which might promote th cells to polarize to th cells and cause the overfunction of t lymphocytes and hematopoiesis failure in saa so we assumed myeloid dendritic cells mdcs may be the key immune cells that cause destruction of hematopoietic cells in saa but the mechanism of activation of mdcs is unclear here we investigated the proteome of mdcs in saa patients to further explore the pathogenesis of saa and the possible antigen that leads to immune activation in saa mdcs from saa patients remission patients and controls were sorted by flow cytometry and examined by twodimensional gel PACE and mass spectrometry intensity changes of spots were detected with statistical significance nine of the spots were identified by malditoftof MS/MS changes in protein expression C2 were found in the saa group these changes reveal that abnormal expression of cofilin glucosephosphate dehydrogenase and Pyr kinase enzyme m in mdcs from saa patients may be the reason for mdc hyperfunction" ], "offsets": [ [ 0, 1226 ] ] } ]

[ { "id": "3335", "type": "abbreviation", "text": [ "SAA" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "medal", "db_id": "severe aplastic anemia" } ] } ]

[]

[]

[]

[ { "id": "3337", "type": "PubMed abstract", "text": [ "the protozoan parasite plasmodium is transmitted by female anopheles mosquitoes and undergoes obligatory development within a parasitophorous vacuole in hepatocytes before it is released into the bloodstream the transition to the blood stage was previously shown to involve the packaging of EE merozoites into membranesurrounded LDV called merosomes which are delivered directly into liver sinusoids however it was unclear whether the membrane of these merosomes was derived from the parasite membrane the parasitophorous vacuole membrane or the host CM this knowledge is required to determine how phagocytes will be directed against merosomes here we fluorescently label the candidate CM and use live cell imaging to show that the merosome membrane derives from the host cell membrane we also demonstrate that proteins in the host cell membrane are lost during merozoite liberation from the parasitophorous vacuole immediately after the breakdown of the PVM the host cell mitochondria begin to degenerate and protein biosynthesis arrests the intact host cell BPM surrounding merosomes allows plasmodium to mask itself from the host IS and bypass the numerous kupffer cells on its way into the bloodstream this represents an effective strategy for evading host defenses before establishing a blood stage infection" ], "offsets": [ [ 0, 1313 ] ] } ]

[ { "id": "3338", "type": "abbreviation", "text": [ "EE" ], "offsets": [ [ 291, 293 ] ], "normalized": [ { "db_name": "medal", "db_id": "exoerythrocytic" } ] } ]

[]

[]

[]

[ { "id": "3340", "type": "PubMed abstract", "text": [ "the effects of aging and loneliness on cardiomuscles adult or lateonset dystonia typically begins in the neck arm or cranial muscles compared to earlyonset dystonia the area of involvement is more likely to remain focal or segmental dystonia can be considered either primary or nonprimary PTD ptd historically called dt deformans and oppenheims dystonia describes dystonia in isolation excepting tremor without brain degeneration and without an identified acquired cause nonprimary or secondary dystonia encompasses a heterogeneous group of syndromes and etiologies including inherited with or without brain degeneration acquired and complex neurological disorders monogenic forms of dystonia are labeled dyt and enumerated in the order in which they were discovered the current dyt loci comprise a heterogeneous group of disorders table i they can be divided into ptds dystoniaplus syndromes without BB degeneration dystoniaparkinsonism with brain degeneration ie dyt and paroxysmal dyskinesias there are many neurodegenerative genetic disorders that share dystonia as a common feature of disease table ii this chapter will review the genetics of ptd dystoniaplus syndromes without brain degeneration and xlinked dystoniaparkinsonism other genetic dystoniaparkinsonism syndromes and the paroxysmal dyskinesias will not be discussed" ], "offsets": [ [ 0, 1332 ] ] } ]

[ { "id": "3341", "type": "abbreviation", "text": [ "PTD" ], "offsets": [ [ 289, 292 ] ], "normalized": [ { "db_name": "medal", "db_id": "primary torsion dystonia" } ] } ]

[]

[]

[]

[ { "id": "3343", "type": "PubMed abstract", "text": [ "harbour seals phoca vitulina are frequently infected with the lungworms otostrongylus circumlitus and parafilaroides gymnurus the infection is often accompanied by AA bacterial infections and can cause severe bronchopneumonia and even death in affected animals hitherto the detection of lungworm infections was based on post mortem investigations from animals collected within stranding networks and a valid detection method for live freeranging harbour seals was not available recently an elisa was developed for detecting lungworm antibodies in harbour seal serum using MSP msp of the bovine lungworm dictyocaulus viviparus as recombinant diagnostic antigen to determine lungworm seroprevalence in freeranging harbour seals SS was taken from four different seal age groups n resulting in an overall prevalence of of males of females of harbour seals up to six weeks of age were SP as were of seals between six weeks and six months between six and months and of seals over months of age in the months and over age group SP animals showed statistically significant reductions in body weight p and length p sera from lungworm INF harbour seals in rehabilitation n revealed that duration of antibody persistence may be similar to that of lungworm INF cattle but further studies are needed to confirm this phylogenetic analyses of msp sequences of different marine and terrestrial mammal parasitic nematodes revealeidual questions specifically regarding knowledge of glycemic control p and frequency of SM of blood gl p inappropriate foot care practices across both cohorts were highlighted no significant intercohort differences in particular survey sections were identified the scores in the SVR and podiatric sections of the questionnaire highlight patterns of common health misconceptions and some highly inappropriate foot care practices respectively across the entire sample in particular the dearth of patient awareness regarding uncontrolled blood glucose and its relationship to dfu development amputation and associated morbidity is shown to be an area of concern this must be addressed a priori" ], "offsets": [ [ 0, 2102 ] ] } ]

[ { "id": "3344", "type": "abbreviation", "text": [ "MSP" ], "offsets": [ [ 572, 575 ] ], "normalized": [ { "db_name": "medal", "db_id": "major sperm protein" } ] } ]

[]

[]

[]

[ { "id": "3346", "type": "PubMed abstract", "text": [ "potassium channels belong to the largest and the most diverse superfamilies of SAC among them caactivated k channels kca comprise many members based on their single channel conductance they are divided into three subfamilies big conductance bkca intermediate conductance ikca and small conductance skca sk sk and sk ICa are divided into two main families voltage gatedvoltage dependent ca channels and nonvoltage gatedvoltage independent ca channels based on their electrophysiological and pharmacological properties and on the tissue where there are expressed voltage gated ca channels cav are divided into families ttype ltype ntype pqtype and rtype ca nonvoltage gated ICa comprise the trp trpc trpv trpm trpa trpp trpml and trpn and orai orai to orai families and their partners stim stim to stim a depolarization is needed to activate voltagegated ICa while nonvoltage gated ICa are activated by ca depletion of the endoplasmic reticulum stores socs or by receptors rocs these two ca channel families also control constitutive ca entries for reducing the energy consumption and for the fine regulation of ca kca and ICa appear associated as complexes in excitable and nonexcitable cells interestingly there is now evidence that kcaca channel complexes are also found in cancer cells and contribute to cancerassociated functions such as cell proliferation cell migration and the capacity to develop metastased therapy in diseases with raised intracranial pressure and vascular diseases affecting the eye despite the capabilities of modern ultrasound systems and its scientific validation occs has not gained widespread use in neurological practice in this review the authors describe the technique and main parameter settings of occs systems to reduce potential risks as thermal or cavitational effects for CS orbital structures applications of occs are the determination of intracranial pressure in EM and followup evaluations of idiopathic intracranial hypertension and VVI shunting by measuring the optic nerve sheath diameter a diameter of mm corresponds well with symptomatically increased intracranial pressure cmho occs also helps to discriminate between different etiologies of central retinal artery occlusion by visualization of a spot sign and doppler flow analysis of the CE retinal i.a. and aids the differential diagnosis of papilledema at the end perspectives are illustrated that combine established ultrasound methods such as transcranial colorcoded US with occs" ], "offsets": [ [ 0, 2483 ] ] } ]

[ { "id": "3347", "type": "abbreviation", "text": [ "US" ], "offsets": [ [ 2471, 2473 ] ], "normalized": [ { "db_name": "medal", "db_id": "sonography" } ] } ]

[]

[]

[]

[ { "id": "3349", "type": "PubMed abstract", "text": [ "in the university of virginia medical center began implementation of a medical NIS based on mandatory POE the implementation process was much more difficult than expected the program experienced considerable delays and cost much more than was originally estimated although there were some legitimate questions concerning the userfriendliness of the new technology these were less significant than the cultural and behavioral problems encountered the new system challenged basic institutional assumptions it disturbed traditional patterns of conduct and forced people to modify established practice routines real progress toward the integration of the system into the centers operational SC occurred only T3 a senior management team representing important sectors of the hospital staff and administration began meeting regularly to address the institutionwide issues that had been raised the author describes the problems that occurred and the organizational behaviors on which they were based analyzes the lessons learned documents the progress that has been achieved and outlines the challenges that remain the centers experience provides insight into the issue of technologydriven organizational transformation in academic medical centers recommendations for successful introduction of similar agents of institutional NC are presented" ], "offsets": [ [ 0, 1336 ] ] } ]

[ { "id": "3350", "type": "abbreviation", "text": [ "POE" ], "offsets": [ [ 102, 105 ] ], "normalized": [ { "db_name": "medal", "db_id": "physician order entry" } ] } ]

[]

[]

[]

[ { "id": "3352", "type": "PubMed abstract", "text": [ "neuronal injury triggers the release of ciliary neurotrophic factor cntf promoting local neuronal repair but producing SVR effects of anorexia and lean body WL due to the rapid rate of systemic protein loss stimulated by cntf we hypothesis and the complications of immobilisation unconscious victims of polytrauma often come under the care of several subspecialties with the direct consequence that management can be contradictory and lack standardisation ATLS and eastern association for the surgery of trauma guidelines can reinforce and even contribute to nonstandardised care having performed this clinician survey we have now developed a multidisciplinary management protocol AGA for NI" ], "offsets": [ [ 0, 691 ] ] } ]

[ { "id": "3353", "type": "abbreviation", "text": [ "ATLS" ], "offsets": [ [ 456, 460 ] ], "normalized": [ { "db_name": "medal", "db_id": "advanced trauma life support" } ] } ]

[]

[]

[]

[ { "id": "3355", "type": "PubMed abstract", "text": [ "the authors studied patients affected by anaplastic gliomas in regard to the killer ADCC and A-NK spontaneous LMC immunological functions by counting the cr PR in change CL and k cell cultures respectively these parameters were also evaluated in HD as control in patients affected by TCC and in nine cases of kidney cancer our data show preoperatively a statistically significant impairment of adcc and slmc activity in glioma patients as compared both with controls bladder and kidney cancer patients the particular impairment of k and nk functions in gliomas is discussed with regard to the TPS features of CNS system HM an improvement of adcc activity was also found in the postoperative samples this finding confirms other reports about partial restoring of altered immunocompetence after surgery suggesting a link between extention of tumor mass and impaired immunological reactions" ], "offsets": [ [ 0, 887 ] ] } ]

[ { "id": "3356", "type": "abbreviation", "text": [ "LMC" ], "offsets": [ [ 110, 113 ] ], "normalized": [ { "db_name": "medal", "db_id": "lymphocytemediated cytotoxicity" } ] } ]

[]

[]

[]

[ { "id": "3358", "type": "PubMed abstract", "text": [ "TRP tyrp is a transmembrane glycoprotein that is specifically expressed in melanocytes and melanoma cells preclinical data suggest that mabs targeting tyrp confer antimelanoma activity imcds is a recombinant human igg mab targeting tyrp here we report the firstinhuman phase iib trial of imcds" ], "offsets": [ [ 0, 293 ] ] } ]

[ { "id": "3359", "type": "abbreviation", "text": [ "TRP" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "medal", "db_id": "tyrosinaserelated protein" } ] } ]

[]

[]

[]

[ { "id": "3361", "type": "PubMed abstract", "text": [ "interests in acinetobacter haemolyticus lipases are showing an increasing trend concomitant with growth of the enzyme industry and the widening search for novel enzymes and applications here we present a structural MM that reveals the key catalytic residues of lipase kv from a haemolyticus homology modeling of the lipase structure was based on the structure of a carboxylesterase from the archaeon archaeoglobus fulgidus as the template which has a CS that is identical to that of lipase kv the lipase kv model is comprised of a single compact domain consisting of seven parallel and one antiparallel βstrand surrounded by nine αhelices three structurally conserved activesite residues ser asp and his and a tunnel through which substrates access the IB site were identified docking of the substrates TB and palmitic acid into the ph modeled lipase kv AS CS revealed an aromatic platform responsible for the substrate recognition and preference toward TB the resulting binding modes from the docking simulation correlated well with the experimentally determined hydrolysis DP for which ph and TB being the optimum ph and preferred ATP the results reported herein provide useful insights into future structurebased tailoring of lipase kv to modulate its catalytic activity" ], "offsets": [ [ 0, 1275 ] ] } ]

[ { "id": "3362", "type": "abbreviation", "text": [ "TB" ], "offsets": [ [ 805, 807 ] ], "normalized": [ { "db_name": "medal", "db_id": "tributyrin" } ] } ]

[]

[]

[]

[ { "id": "3364", "type": "PubMed abstract", "text": [ "we report the results of the release and tapeshortening techniques in PP pubovaginal slings of female patients who had undergone midurethral sling procedures TVT procedure and suburethral polypropylene sparc in cases in which postoperative retention occurred the patients were offered release or tape cutting women reporting postoperative UI underwent a tapeshortening procedure in these patients the tape was shortened by the use of clips mean followup time T3 the release andor the shortening operations was months range a total of women ranging from to years old mean were included in this study upon the latest followup six women exhibited prolonged UR and subsequently underwent a release procedure n or a tapecutting procedure n after the release procedure all patients remained continent but one patients UR issues were not resolved and she subsequently underwent a tapecutting both of the patients who underwent the cutting procedure then developed recurrent stress urinary incontinence the tapeshortening technique was conducted with nine patients seven of these patients recovered their continence and no one patient experienced any urinary retention or other voiding difficulties two patients reported only minimal stress leakage and elected to undergo no further interventions our findings suggest that tension plays a substantial role in tensionfree midurethral sling procedures" ], "offsets": [ [ 0, 1391 ] ] } ]

[ { "id": "3365", "type": "abbreviation", "text": [ "UR" ], "offsets": [ [ 812, 814 ] ], "normalized": [ { "db_name": "medal", "db_id": "urinary retention" } ] } ]

[]

[]

[]

[ { "id": "3367", "type": "PubMed abstract", "text": [ "polarity of many cell types is controlled by a protein complex consisting of bazookapar baz par and aPKC apkc in drosophila the bazparapkc complex is required for the control of cell polarity in the follicular epithelium in ectodermal epithelia and NBs apkc is the main signaling component of this complex that functions by phosphorylating downstream targets while the pdz domain proteins baz and par control the subcellular localization and kinase activity of apkc we compared the mutant phenotypes of an apkc null S2 with those of four novel apkc alleles harboring point mutations that abolish the kinase activity or the IB of apkc to par we show that these point alleles retain full functionality in the control of F2 cell polarity but produce strong lossoffunction phenotypes in embryonic epithelia and neuroblasts our data combined with MD show that the kinase activity of apkc and its ability to bind par are only required for a subset of its functions during OD revealing tissuespecific differences in the way that apkc controls cell polarity" ], "offsets": [ [ 0, 1049 ] ] } ]

[ { "id": "3368", "type": "abbreviation", "text": [ "aPKC" ], "offsets": [ [ 100, 104 ] ], "normalized": [ { "db_name": "medal", "db_id": "atypical protein kinase c" } ] } ]

[]

[]

[]

[ { "id": "3370", "type": "PubMed abstract", "text": [ "this paper reviews RII frameworks for cell therapy products in japan two procedures are used to investigate the use of new cell therapy products in japan one is to perform clinical trials in accordance with the provisions of the pharmaceuticals affairs act paa the other is to perform clinical research in accordance with the provisions of the medical practitioners act for full commercialization of medical products in japan we must consider the universal health care system all medical products used to treat patients in the system must be approved in accordance with the provisions of the paa as drugs or medical devices thus researchers in academia who have developed new cell therapy products should consider performing clinical trials in accordance with the provisions of the paa to test their products clinically this article describes development and review processes for new drugdevice applications in accordance with the provisions of the paa and gives an example of clinical review of a cell therapy product by the pharmaceuticals and MDA" ], "offsets": [ [ 0, 1049 ] ] } ]

[ { "id": "3371", "type": "abbreviation", "text": [ "MDA" ], "offsets": [ [ 1046, 1049 ] ], "normalized": [ { "db_name": "medal", "db_id": "medical devices agency" } ] } ]

[]

[]

[]

[ { "id": "3373", "type": "PubMed abstract", "text": [ "the coefficients of partitioning kpew between lowdensity polyethylene ldpe film µm thickness and water for polybrominated diphenyl ether pbde congeners were determined based on a regression analysis of sorption kinetics over an extended SE period up to d a curvilinear relationship between log kpew and log kow octanolwater partition coefficient was obtained for the target bde congeners with the TP at log kow approximately previously obtained dietary uptake efficiencies of bde congeners in common carp cyprinus carpio were also found to relate curvilinearly to log kow in addition fieldmeasured relative abundances of bde compiled from previous investigations conducted in the pearl river delta of south china were significantly p higher in abiotic samples n from matrices than in biotic samples n from matrices suggesting the likelihood for reduced bioavailability of bde in certain biota finally a molecularscale analysis indicated that the curvilinear rtom severity on patientproxy concordance in reports of patient suicide ideation" ], "offsets": [ [ 0, 1039 ] ] } ]

[ { "id": "3374", "type": "abbreviation", "text": [ "TP" ], "offsets": [ [ 398, 400 ] ], "normalized": [ { "db_name": "medal", "db_id": "turning point" } ] } ]

[]

[]

[]

[ { "id": "3376", "type": "PubMed abstract", "text": [ "the rapid method for baseline separation of ten guanidino compounds in SS from nephritic patients was designed using a single eluent with a column switching system a PGC column and an octadecylbonded silica gel columns were used mm x mm id separation was completed within min the SD baseline permitted highly sensitive PCD with excellent reproducibility the system was applied to analyze guanidino EDC in sera from nephritic patients the hemodialysis process could not CR eliminate guanidino compounds and the degree of removal varied between patients the rho among metabolites indicated the differences in disease" ], "offsets": [ [ 0, 614 ] ] } ]

[ { "id": "3377", "type": "abbreviation", "text": [ "PGC" ], "offsets": [ [ 166, 169 ] ], "normalized": [ { "db_name": "medal", "db_id": "porous graphitic carbon" } ] } ]

[]

[]

[]

[ { "id": "3379", "type": "PubMed abstract", "text": [ "we reviewed adverse events following receipt of inactivated mouse brainderived japanese encephalitis je vaccine reported to the us vaccine adverse event reporting system vaers from to during this period vaers received adverse event reports following je vaccination per doses distributed were classified as HSRs per doses and four were classified as neurologic events per doses twentythree reports described serious AEs per doses distributed there were no reports of encephalitis meningitis or guillainbarré syndrome as reported previously HSRs were common among persons receiving inactivated mouse brainderived je vaccine" ], "offsets": [ [ 0, 622 ] ] } ]

[ { "id": "3380", "type": "abbreviation", "text": [ "HSRs" ], "offsets": [ [ 540, 544 ] ], "normalized": [ { "db_name": "medal", "db_id": "hypersensitivity reactions" } ] } ]

[]

[]

[]

[ { "id": "3382", "type": "PubMed abstract", "text": [ "ozonation and adsorption onto AC were tested for the removal micropollutants of personal care products from aerobically treated grey water milliq water spiked with micropollutants μgl was ozonated at a dosing rate of in min this effectively removed four parabens bisphenola hexylcinnamic aldehyde methylbenzylidenecamphor mbc BP bp triclosan galaxolide and ethylhexyl methoxycinnamate T3 min the removal efficiency of benzalkonium chloride was tonalide and nonylphenol octocrylene and phenylbenzimidazolesulfonic acid pbsa ozonation of aerobically treated grey water at an applied ozone dose of mgl reduced the concentrations of octocrylene nonylphenol triclosan galaxolide tonalide and methylbenzylidenecamphor to below limits of quantification with removal efficiencies of at least CR adsorption of all studied micropollutants onto PAC pac was observed in batch tests with milliq water spiked with μgl at a pac dose of gl and a contact time of min three granular activated carbon gac column experiments were operated to treat aerobically treated grey water the operation of a gac column with aerobically treated grey water spiked with micropollutants in the range of μgl at a flow of BV bvh showed micropollutant removal efficiencies higher than during the operation time of bv no breakthrough of toc or micropollutants was observed removal of micropollutants from aerobically treated grey water was tested in a gac column at a flow of bvh BPA triclosan tonalide bp galaxolide nonylphenol and pbsa were effectively removed even after a stable toc breakthrough of had been reached T3 spiking the aerobically treated effluent with micropollutants to concentrations of μgl efficient removal to below limits of quantification continued for at least bv both ozonation and adsorption are suitable techniques for the removal of micropollutants from aerobically treated grey water" ], "offsets": [ [ 0, 1878 ] ] } ]

[ { "id": "3383", "type": "abbreviation", "text": [ "BV" ], "offsets": [ [ 1189, 1191 ] ], "normalized": [ { "db_name": "medal", "db_id": "bed volumes" } ] } ]

[]

[]

[]

[ { "id": "3385", "type": "PubMed abstract", "text": [ "the side chains of r and n interact with the phosphodianion of dihydroxyacetone phosphate dhap bound to glycerol phosphate dehydrogenase gpdh the ra na and rana mutations of gpdh result in and kcalmol destabilization respectively of the transition state for gpdhcatalyzed reduction of dhap by the reduced form of nicotinamide adenine CpG the na mutation results in a kcalmol decrease in the intrinsic phosphodianion binding SE which is larger than the kcalmol effect of the mutation on the stability of the TS for reduction of dhap a kcalmol stabilization of the TS for unactivated hydride transfer to the truncated ATP glycolaldehyde ga and a NC in the effect of phosphite dianion on gpdhcatalyzed reduction of ga from strongly activating to inhibiting the na mutation breaks the network of hydrogen bonding side chains asn thr asn lys asp and lys which connect the dianion activation and catalytic CS of gpdh we propose that this disruption dramatically alters the performance of gpdh at these sites" ], "offsets": [ [ 0, 1001 ] ] } ]

[ { "id": "3386", "type": "abbreviation", "text": [ "TS" ], "offsets": [ [ 507, 509 ] ], "normalized": [ { "db_name": "medal", "db_id": "transition state" } ] } ]

[]

[]

[]

[ { "id": "3388", "type": "PubMed abstract", "text": [ "we used thoracoscopy for the successful ligation and transection of a racemose hemangioma of bronchial artery the patient was a yearold woman who had been admitted to our hospital because of hemoptysis bronchoscopic examination revealed bulging lesions covered with normal BM in the RA b and b and bronchial arteriography revealed a shunt between the RA bronchial arteries and pulmonary arteries and veins ligation and transection of the RA bronchial i.a. under thoracoscopy was performed hemoptysis has not recurred months after the T0 thoracoscopic ligation and transection of bronchial i.a. may be an ERP and less invasive procedure for the treatment of racemose hemangioma" ], "offsets": [ [ 0, 676 ] ] } ]

[ { "id": "3389", "type": "abbreviation", "text": [ "BM" ], "offsets": [ [ 273, 275 ] ], "normalized": [ { "db_name": "medal", "db_id": "bronchial mucosa" } ] } ]

[]

[]

[]

[ { "id": "3391", "type": "PubMed abstract", "text": [ "in recent years cement composites based on calcium silicate have been more generally considered for medical applications calcium silicate cement are among the categories that are used in dental root canal treatment the aim of this study is to make new calcium silicate cement with DCP and chitosan additives to preserve and strengthen desirable properties of this type of cements in this T0 composite dental cement based on calcium silicate was prepared then effect of adding biodegradable and biocompatible CP such as chitosan on setting properties and its structure were studied in this study a combination of calcium silicate DCP dcp and bismuth oxide bi" ], "offsets": [ [ 0, 657 ] ] } ]

[ { "id": "3392", "type": "abbreviation", "text": [ "DCP" ], "offsets": [ [ 281, 284 ] ], "normalized": [ { "db_name": "medal", "db_id": "dicalcium phosphate" } ] } ]

[]

[]

[]

[ { "id": "3394", "type": "PubMed abstract", "text": [ "EMA ema and juvenile myoclonic epilepsy jme are two separate epileptic syndromes included in the new classification of epilepsies and epileptic syndromes by ilae in both are idiopathic generalized epilepsies with their clinical onset in the first two decades ema is characterized by eyelid myoclonia associated with absences and photosensitivity selfinduced seizures are frequently seen in ema it can be associated with mildly mental retardation and resistance to treatment jme includes three types of generalized seizures typical absences myoclonic jerks and generalized tonicclonic seizures the myoclonic jerks occur almost exclusively on awakening involve preferently the upper extremities may rarely affect the lower extremities or the entire body more severe attacks may be accompanied by a fall the myoclonic jerks occur rarely in ema they are usually mild and are freqently restricted to the upper extremities GTC seizures photosensitivity and generalized polyspikewave discharges provoked by eye closure are features of both epileptic syndromes in this T0 we describe four female patients with eyelid myoclonia associated with absences myoclonic jerks causing falling down and rare generalized tonicclonic seizures all patients had good school performance and total seizure control under sodium valproate treatment their eegs show generalized polyspikewave discharges with a frequency of hz always appearing a few seconds after eye closure and photoparoxysmal response these patients show the characterictics of both epileptic syndromes it is clinically important to make a syndromic diagnosis for an optimum advise on treatment lifestyle restrictions and prognosis in this T0 we have gathered evidence that ema and jme are dynamic syndromes that tend to evolve into one another" ], "offsets": [ [ 0, 1786 ] ] } ]

[ { "id": "3395", "type": "abbreviation", "text": [ "EMA" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "medal", "db_id": "eyelid myoclonia with absences" } ] } ]

[]

[]

[]

[ { "id": "3397", "type": "PubMed abstract", "text": [ "GP is known to affect the peak bone mass and BL T3 maturation however little is known about how polymorphic genes on chromosome x chr x modulate BL T3 maturation we previously reported a quantitative trait locus qtl on chr x designated pbd which had a suggestive linkage to BMC in male samp and samp mice in this T0 we aimed to clarify the effects of pbd on the skeletal phenotype we generated a congenic CS ppx carrying a cm sampderived chr x interval on a samp genetic BG the effects of pbd on the bone phenotype were determined by microcomputed tomography microct wholebody DEXA dxa serum bone turnover markers and histomorphometric parameters both the bone area fraction bata on microct and wholebody dxa revealed reduced BL in ppx compared with that in samp the SS concentrations of bone turnover markers at months of age were significantly lower in ppx than in samp but did not differ at months of age these results were observed in female mice but not in male mice in conclusion a qtl within a segregated cm interval on chr x is sexspecifically related to the rate of BL after maturation" ], "offsets": [ [ 0, 1094 ] ] } ]

[ { "id": "3398", "type": "abbreviation", "text": [ "DEXA" ], "offsets": [ [ 577, 581 ] ], "normalized": [ { "db_name": "medal", "db_id": "dualenergy xray absorptiometry" } ] } ]

[]

[]

[]

[ { "id": "3400", "type": "PubMed abstract", "text": [ "fragile x syndrome the most common form of inherited mental impairment in humans is caused by the absence of the FMRP fmrp due to a cgg CAG repeat expansion in the untranslated region utr and subsequent translational silencing of the FMR1 fmr gene fmrp which is proposed to be involved in the translational regulation of specific neuronal messenger rna mrna targets contains an arginineglycineglycine rgg box RBD that has been shown to bind with high affinity to gquadruplex forming mrna structures fmrp undergoes AS and the binding of fmrp to a proposed gquadruplex structure in the coding region of its mrna named fbs has been proposed to affect the mrna splicing events at exon in this study we used biophysical methods to directly demonstrate the folding of fmr fbs into a AA structure that contains two specific gquadruplexes and analyze its interactions with several fmrp isoforms our results show that minor splice isoforms iso and iso created by the usage of the second and third acceptor CS at exon bind with higher affinity to fbs than fmrp iso which is created by the usage of the first acceptor site fmrp iso and iso cannot undergo phosphorylation an fmrp posttranslational modification shown to modulate the protein translation regulation thus their expression has to be tightly regulated and this might be accomplished by a feedback mechanism involving the fmrp interactions with the gquadruplex structures formed within fmr mrna" ], "offsets": [ [ 0, 1443 ] ] } ]

[ { "id": "3401", "type": "abbreviation", "text": [ "FMRP" ], "offsets": [ [ 113, 117 ] ], "normalized": [ { "db_name": "medal", "db_id": "fragile x mental retardation protein" } ] } ]

[]

[]

[]

[ { "id": "3403", "type": "PubMed abstract", "text": [ "we have examined the expression of the interleukin beta il beta gene during the granulocytic differentiation of two promyeloid one cell lines hl and nb hl is known to differentiate along the granulocytic pathway after treatment with transretinoic acid transra whereas treatment with PMA acetate pma leads to OD of mature macrophages nb cells are derived from the bone marrow initial phase of treatment epoetin is up to twice as effective when SC rather than intravenously responding patients will normally do so within months of starting epoetin failures to respond are usually due to ID or intercurrent disease other diseases associated with anaemia and an inappropriately low serum epoetin level include prematurity the anaemia of CA and rheumatoid ICA the baseline SS endogenous erythropoietin may provide a guide to response in some of these cases some encouraging results are being published situations where the serum erythropoietin C2 are normal or elevated where epoetin has been employed include boosting of haematocrit presurgery as an adjunct to ABD treatment of anaemic patients with MDS syndromes and improvement of athletic performances" ], "offsets": [ [ 0, 1150 ] ] } ]

[ { "id": "3404", "type": "abbreviation", "text": [ "ABD" ], "offsets": [ [ 1057, 1060 ] ], "normalized": [ { "db_name": "medal", "db_id": "autologous blood donation" } ] } ]

[]

[]

[]

[ { "id": "3406", "type": "PubMed abstract", "text": [ "to clarify the role of genetic polymorphisms of gsto rs and gsto rs in individual susceptibility to UBC" ], "offsets": [ [ 0, 103 ] ] } ]

[ { "id": "3407", "type": "abbreviation", "text": [ "UBC" ], "offsets": [ [ 100, 103 ] ], "normalized": [ { "db_name": "medal", "db_id": "urinary bladder cancer" } ] } ]

[]

[]

[]

[ { "id": "3409", "type": "PubMed abstract", "text": [ "the activity of metabolic enzymes adenosine and thymidine has been studied in the blood serum and lymphocytes of healthy people and oncological patients aged an increase in the activity of thymidine kinase ec an enzyme of thymidine biosynthesis was observed in the BS of oncological patients against a BG of a sharp decrease in the activity of thymidine phosphorylase ec a catabolic enzyme the revealed enzymic shifts have been observed in breast CA patients after in patients with the stomach cancerafter it is found that an increase in the activity of adenosine deaminase ec and nucleotidase of amp ec in the BS of oncological patients is accompanied by a sharp decrease in the activity of these enzymes in lymphocytes" ], "offsets": [ [ 0, 720 ] ] } ]

[ { "id": "3410", "type": "abbreviation", "text": [ "BS" ], "offsets": [ [ 611, 613 ] ], "normalized": [ { "db_name": "medal", "db_id": "blood serum" } ] } ]

[]

[]

[]

[ { "id": "3412", "type": "PubMed abstract", "text": [ "ABD compartment syndrome acs is a known complication of ruptured ABD aortic aneurysm raaa repair and can occur with either endovascular evar or or we hypothesize that the underlying mechanism for the OD of acs may differ for patients treated with evar or open operation" ], "offsets": [ [ 0, 269 ] ] } ]

[ { "id": "3413", "type": "abbreviation", "text": [ "or" ], "offsets": [ [ 144, 146 ] ], "normalized": [ { "db_name": "medal", "db_id": "open repair" } ] } ]

[]

[]

[]

[ { "id": "3415", "type": "PubMed abstract", "text": [ "the inability to achieve adequate nutrition and weight loss are serious problems for patients with advanced parkinsons disease pd to ensure the optimal NI of nutrition and fluids and to administer levodopacarbidopa intestinal gel lcig which patients need to increase or maintain their mobility as long as possible different artificial FF tubes can be used although PEG peg tubes are frequently used in medical practice there is little research that addresses key questions including if and when to administer artificial fluids nutrition andor lcig via tubes WG through tube FF is only possible for some patients nurses should keep in mind that tube IS and feeding may lead to frequent adverse events administering lcig via tubes is usually advisable as it seems to enhance patients mobility and therefore has positive outcomes in terms of the quality of life of patients and their families lim et al the authors aimed to examine the use and consequences of providing nutrition and lcig via gastrostomy tubes in pd patients with advanced disease" ], "offsets": [ [ 0, 1044 ] ] } ]

[ { "id": "3416", "type": "abbreviation", "text": [ "PEG" ], "offsets": [ [ 365, 368 ] ], "normalized": [ { "db_name": "medal", "db_id": "percutaneous endoscopic gastrostomy" } ] } ]

[]

[]

[]

[ { "id": "3418", "type": "PubMed abstract", "text": [ "this paper presents a review of the pathogenesis of abdominal pain in ruminants the CR clinical examination of animals with colic and the symptomatology of the different conditions producing abdominal pain further diagnostic procedures such as abdominal ultrasonography explorative laparotomy and DL are discussed" ], "offsets": [ [ 0, 313 ] ] } ]

[ { "id": "3419", "type": "abbreviation", "text": [ "DL" ], "offsets": [ [ 297, 299 ] ], "normalized": [ { "db_name": "medal", "db_id": "diagnostic laparoscopy" } ] } ]

[]

[]

[]

[ { "id": "3421", "type": "PubMed abstract", "text": [ "child undernutrition remains a challenge globally and in the geographically diverse country of ethiopia improving dietary diversity and consumption of ASF are important for improving child nutrition and corresponding health outcomes" ], "offsets": [ [ 0, 232 ] ] } ]

[ { "id": "3422", "type": "abbreviation", "text": [ "ASF" ], "offsets": [ [ 151, 154 ] ], "normalized": [ { "db_name": "medal", "db_id": "animal source foods" } ] } ]

[]

[]

[]

[ { "id": "3424", "type": "PubMed abstract", "text": [ "mus musculus is the only known species from which embryonic stem cells esc can be isolated under conditions requiring only LIF lif other species are nonpermissive in lif media and form developmentally primed epiblast stem cells episc similar to cells derived from postimplantation egg cylinders to evaluate whether nonpermissiveness extends to induced CFU-S stem cells ipsc we derived ipsc from the eight founder strains of the mouse collaborative cross two strains nodshiltj and the wsbeij were nonpermissive consistent with the previous classification of nodshiltj as nonpermissive to esc derivation we determined nonpermissiveness is recessive and that nonpermissive genomes do not compliment we overcame ipsc nonpermissiveness by using gskb and mek inhibitors with SS a technique we termed is reprogramming although used for esc derivation gskb and mek inhibitors have not been used during ipsc reprogramming because they inhibit survival of progenitor differentiated cells ipsc derived in is are more transcriptionally similar to esc than episc indicating that is reprogramming acts to overcome genetic BG constraints finally of species tested for esc or ipsc derivation only some m musculus strains are permissive under lif culture conditions suggesting that this is an evolutionarily derived characteristic in the m musculus lineage" ], "offsets": [ [ 0, 1339 ] ] } ]

[ { "id": "3425", "type": "abbreviation", "text": [ "LIF" ], "offsets": [ [ 123, 126 ] ], "normalized": [ { "db_name": "medal", "db_id": "leukemia inhibitory factor" } ] } ]

[]

[]

[]

[ { "id": "3427", "type": "PubMed abstract", "text": [ "the effects of dgalactosamine on induction of preneoplastic GST-P positive liver foci were investigated in f rats pretreated with diethylnitrosamine den in an attempt to improve the predictive value of the mediumterm bioassay system developed in our laboratory two weeks T3 the initial single ip dose mgkg of den administration of test compounds was commenced simultaneously with an ip injection of dgalactosamine at a dose of mgkg body wt all rats were then subjected to twothirds partial hepatectomy ph at week and sacrificed for assessment of lesion yield at week measurement and comparison of the numbers and Az of GST-P positive gstp foci per cm revealed a positive response to more carcinogens including nonhepatocarcinogens than did the same bioassay system without i.t. of dgalactosamine thus the results suggest that inclusion of this extra proliferative stimulus may improve the mediumterm detection of carcinogens and modifiers" ], "offsets": [ [ 0, 938 ] ] } ]

[ { "id": "3428", "type": "abbreviation", "text": [ "GST-P" ], "offsets": [ [ 60, 65 ] ], "normalized": [ { "db_name": "medal", "db_id": "glutathione stransferase placental form" } ] } ]

[]

[]

[]

[ { "id": "3430", "type": "PubMed abstract", "text": [ "SGs sgs are mrna triage sites that are formed in response to a variety of cellular AS to study how sgs bring about the massive spatial compartmentalization we monitored the localization of various rnabinding proteins rbps targeted to sgs upon SE to AS we discovered that concomitant with the onset of eifalpha phosphorylation rbps accumulate locally in the cytoplasm which leads to increased intermolecular interactions and the formation of robustly detergentresistant foci subsequently MTs mts mediate the ordered spatial organization of sgs and the recruitment of a set of nuclearlocalized sg components to the cytoplasm meanwhile mts did not appear to be required for the maintenance of sg distro one year eleven published cases were managed by combined surgery and SVR antibiotics with an average of surgeries per patient and seven weeks to months of antibiotics all our patients were disease free on final followup thirteen cases were resolved functional outcomes were reported for eight cases comparison of functional outcome was not possible because different parameters were used in different reports aggressive debridement susceptibilityguided antibiotics and supervised rehabilitation resulted in infection control and acceptable hand CF for our patients standardised data collection on subsequent cases would facilitate outcome monitoring and formulation of a treatment guideline for this disease" ], "offsets": [ [ 0, 1407 ] ] } ]

[ { "id": "3431", "type": "abbreviation", "text": [ "SGs" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "medal", "db_id": "stress granules" } ] } ]

[]

[]

[]

[ { "id": "3433", "type": "PubMed abstract", "text": [ "herpesvirus saimiri is known to encode a homolog of human complement regulators named CCP homolog ccph we have previously reported that this virally encoded inhibitor effectively inactivates complement by supporting factor imediated inactivation of complement proteins B6 and cb termed cofactor activity as well as by accelerating the irreversible decay of the classicallectin and alternative pathway c convertases termed decayaccelerating activity to fine map its PET sites in the present T0 we have generated a homology MM of ccph and performed substitution mutagenesis of its conserved residues PET analyses of substitution mutants of ccph indicated that i amino acids r and f play a critical role in imparting cb and cb cofactor activities ii amino acids r k and k are required for efficient decay of the c convertases iii positively charged amino acids of the linker regions which are dubbed to be critical for functioning in other complement regulators are not crucial for its CF and iv sk and gd mutations substantially enhance its decayaccelerating activities without affecting the cofactor MICs overall our data point out that ionic interactions form a L1 component of the IB interface between ccph and its interacting partners" ], "offsets": [ [ 0, 1236 ] ] } ]

[ { "id": "3434", "type": "abbreviation", "text": [ "CCP" ], "offsets": [ [ 86, 89 ] ], "normalized": [ { "db_name": "medal", "db_id": "complement control protein" } ] } ]

[]

[]

[]

[ { "id": "3436", "type": "PubMed abstract", "text": [ "extrachromosomal dna elements were found in field isolates of rhizoctonia solani belonging to anastomosis CG ag an isolate of ag rh contains a kbp plasmid prs which has a similar at content to mitochondrial dna prs is linear and has knob structures at its ends as revealed by electron microscopy exonuclease digestions show that the linear ends of prs are protected and remain protected even T3 PK digestion prs does not hybridise to nuclear or mitochondrial dnas of its host isolate rh to total dnas of other plasmidless ag isolates or to total dna of plasmidharbouring isolates belonging to different ags cellularfractionation experiments suggest that prs is associated with mitochondria but it remains undecided whether this occurs inside or outside of the organelles the nucleotide sequence of about of the plasmid has been determined revealing no open reading frame longer than amino acids and no known gene or genetic PE is detected in the CS contigs of bp length similar studies were performed with the plasmid prs present in an isolate of ag rh the CS of which exhibits essentially the same features as prs except that its at content resembles that of nuclear dna pathogenicity tests reveal that the isolates rh and r are as virulent as the plasmidless isolates of ag and indicating that the plasmids do not play any role in pathogenicity" ], "offsets": [ [ 0, 1346 ] ] } ]

[ { "id": "3437", "type": "abbreviation", "text": [ "PK" ], "offsets": [ [ 395, 397 ] ], "normalized": [ { "db_name": "medal", "db_id": "proteinase k" } ] } ]

[]

[]

[]

[ { "id": "3439", "type": "PubMed abstract", "text": [ "a total of placentas of twins born in tokyo in were examined only just over one third were DC being MC and dz twins were estimated to account for of the pairs the lower frequency of dz twinning in japan is attributed to lower gonadotropin values in japanese women as compared to european american or african women high fetal morbidity was found in MC twins and this is attributed to a frequent occurrence of vascular anastomoses" ], "offsets": [ [ 0, 428 ] ] } ]

[ { "id": "3440", "type": "abbreviation", "text": [ "DC" ], "offsets": [ [ 91, 93 ] ], "normalized": [ { "db_name": "medal", "db_id": "dichorionic" } ] } ]

[]

[]

[]

[ { "id": "3442", "type": "PubMed abstract", "text": [ "the examination of some of the species involved in the in vivo processes in which dithiocarbamates mobilize Cd from its intracellular deposits indicates that several competing reactions occur rates of hydrolytic decomposition of a series of DTCs capable of mobilizing Cd in vivo have been determined and the solubility SMB and nuclear magnetic resonance nmr spectra of their cadmium complexes have been examined some of the DTCs most ERP in this mobilization process are shown to undergo slow conversion to oxazolidinethiones in the presence of Cd all of the Cd complexes involved in the mobilization process are shown to undergo rapid ligand exchange while dissociative mechanisms based on the turnover of metallothionein are inconsistent with the exp data at least two associative mechanisms are possible these involve attack on the metallothionein by the DTC itself or by a compound derived from it by known metabolic processes" ], "offsets": [ [ 0, 930 ] ] } ]

[ { "id": "3443", "type": "abbreviation", "text": [ "DTCs" ], "offsets": [ [ 424, 428 ] ], "normalized": [ { "db_name": "medal", "db_id": "dithiocarbamates" } ] } ]

[]

[]

[]

[ { "id": "3445", "type": "PubMed abstract", "text": [ "developmental neuropsychology and PET neuroimaging evidence indicates that simple and complex mental calculation is subserved by a frontoparietal network however the effective connectivity connection direction and strength among regions within the frontoparietal network is still unexplored combining eventrelated fmri and multivariate granger causality mapping gcm we administered a multiplication verification task to healthy participants asking them to solve single and doubledigit multiplications the goals of our study were first to identify the ERP connectivity of the multiplication network and second to compare the effective connectivity patterns between a low and a high arithmetical competence ac group the manipulation of multiplication difficulty revealed a frontoparietal network encompassing BL IPS ips left presupplementary motor area presma left precentral gyrus precg and RA dorsolateral prefrontal cortex dlpfc the network was driven by an intraparietal ipsips circuit hosting a representation of numerical quantity intertwined with a frontoparietal dlpfcips circuit engaged in temporary storage and updating of arithmetic operations both circuits received additional inputs from the precg and presma playing more of a supportive role in mental calculation the high ac group compared to the low ac group displayed a greater activation in the right ips and based its calculation more on a FB driven intraparietal ipsips circuit whereas the low competence group more on a FB driven frontoparietal dlpfcips circuit this T0 provides first evidence that multivariate gcm is a CS RPA to investigate effective connectivity of mental processes involved in mental calculation and to compare group level performances for different populations" ], "offsets": [ [ 0, 1751 ] ] } ]

[ { "id": "3446", "type": "abbreviation", "text": [ "IPS" ], "offsets": [ [ 810, 813 ] ], "normalized": [ { "db_name": "medal", "db_id": "intraparietal sulcus" } ] } ]

[]

[]

[]

[ { "id": "3448", "type": "PubMed abstract", "text": [ "preventive surgery of pancreatic adenocarcinoma is warranted by the substantial benefit in prognosis observed in some diseases at highrisk for malignant transformation the main indication is intraductal papillary and mucinous neoplasms in which surgical resection must be proposed in case of main duct involvement conversely in branchduct ipmn surgical indications are selective and based mainly on imaging findings mucinous cystadenoma is almost exclusively observed in female and often localized in the distal pancreas and amenable to a limited resection CAP results in a moderately increased risk of pancreatic CA but screening by imaging is difficult concerning familial chronic pancreatitis risk of cancer is very important and warrants resection up to TP familial pancreatic cancer and some others genetic predispositions are less known the first step of their management is an oncogenetician counsel if screening is indicated it should rely mainly on mri and EUS however indications of preventive pancreatectomy are difficult to established both concerning time and extent of resection" ], "offsets": [ [ 0, 1092 ] ] } ]

[ { "id": "3449", "type": "abbreviation", "text": [ "TP" ], "offsets": [ [ 758, 760 ] ], "normalized": [ { "db_name": "medal", "db_id": "total pancreatectomy" } ] } ]

[]

[]

[]

[ { "id": "3451", "type": "PubMed abstract", "text": [ "to assess risk factors associated with substantial microbial bioburden of lids conjunctivae CLs and storage cases during daily wear of silicone hydrogel CLs" ], "offsets": [ [ 0, 156 ] ] } ]

[ { "id": "3452", "type": "abbreviation", "text": [ "CLs" ], "offsets": [ [ 92, 95 ] ], "normalized": [ { "db_name": "medal", "db_id": "contact lenses" } ] } ]

[]

[]

[]

[ { "id": "3454", "type": "PubMed abstract", "text": [ "mitral valve prolapse mvp is considered to be the most common valvular heart lesion in AD females of reproductive age our report reviews the obstetrical performance and outcome of pregnancies in women with mvp in patients cardiac lesion was suspected due to enigmatic dyspnoea and palpitation during antenatal period four mothers required propranolol for cardiac arrhythmias however all of them tolerated pregnancy and labour well four pregnancies ended in SAB and mother had IUFD due to severe PIH there were term and preterm neonates without congenital abnormality one PT neonate had tracheooesophageal fistula and died hours after corrective surgery the mean birth weight of kg was AGA for mean gestation of weeks when compared to the institutes REF neonatal weight curve L3 endocarditis prophylaxis was recommended in cases having mitral regurgitation and complicated delivery awareness of this common cardiac lesion thorough cardiovascular examination during pregnancy early detection and treatment of cardiac arrhythmias if any are the essential steps to prevent rare but dreaded maternal complications" ], "offsets": [ [ 0, 1108 ] ] } ]

[ { "id": "3455", "type": "abbreviation", "text": [ "IUFD" ], "offsets": [ [ 476, 480 ] ], "normalized": [ { "db_name": "medal", "db_id": "intrauterine fetal death" } ] } ]

[]

[]

[]

[ { "id": "3457", "type": "PubMed abstract", "text": [ "it has been unequivocally demonstrated that hyperthermia degrees c has an potentiating effect on radiotherapy and chemotherapy technical improvements have facilitated the application of both local and wholebody hyperthermia and have thus made this form of treatment available to large numbers of patients randomized phase iii studies performed in patients with breast CA malignant melanoma and CC have convincingly confirmed the increased tau of the combination of radiotherapy with local or regional hyperthermia in comparison with radiotherapy CT the effectiveness of other procedures such as the combination of radio and chemotherapy with RHT regional thermochemotherapy and wholebody hyperthermia has so far been investigated mainly in phase ii studies focusing on HNC cervical and ovarian cancer sarcoma malignant germ SCT and rectal carcinoma however the actual place of hyperthermia as a permanent PE in a multimodal therapeutic concept has yet to be shown in prospective phase iii studies" ], "offsets": [ [ 0, 996 ] ] } ]

[ { "id": "3458", "type": "abbreviation", "text": [ "RHT" ], "offsets": [ [ 642, 645 ] ], "normalized": [ { "db_name": "medal", "db_id": "regional hyperthermia" } ] } ]

[]

[]

[]

[ { "id": "3460", "type": "PubMed abstract", "text": [ "subfertility is one of the most common problems observed in F1 males but the etiology remains unknown in most of the cases although proteomic differences in the spermatozoa and seminal plasma between breeds have been investigated the possible differences at the sperm F0 cells and supportingnourishing cells have not been studied the present T0 reports the differential proteomic profile of spermatogenic and sertoli cells in F1 and purebred bulls testis was removed by unilateral castration of peripubertal bulls months age four each from F1 holstein friesian × tharparkar exotic purebred holstein friesian hf and indigenoussociated with the mode of delivery the purpose of this T0 was to compare the level of il in mothers who delivered via cesarean section and vaginally" ], "offsets": [ [ 0, 774 ] ] } ]

[ { "id": "3461", "type": "abbreviation", "text": [ "F1" ], "offsets": [ [ 426, 428 ] ], "normalized": [ { "db_name": "medal", "db_id": "crossbred" } ] } ]

[]

[]

[]

[ { "id": "3463", "type": "PubMed abstract", "text": [ "wide geographic variations in survival for gastric CA in europe have been reported the aim of this study was to analyse the effect of stage at diagnosis treatment and CA characteristics on LTS for GC in populations covered by CRs" ], "offsets": [ [ 0, 229 ] ] } ]

[ { "id": "3464", "type": "abbreviation", "text": [ "CRs" ], "offsets": [ [ 226, 229 ] ], "normalized": [ { "db_name": "medal", "db_id": "cancer registries" } ] } ]

[]

[]

[]

[ { "id": "3466", "type": "PubMed abstract", "text": [ "elements of high atomic number backscatter electrons that carry information of cytochemical and of immunocytochemical significance in high resolution scanning electron microscopy sem reaction products of enzyme cytochemistry containing lead or osmium have been used to localize the CS of phosphatase and of endogenous peroxidase respectively particles of CG ranging in diameter from to nm have been successfully used to label CSA specifically identified by mu monoclonal antibodies the diagnostic potential of the scanning electron microscope in clinical hematology appears to be considerably enhanced by the use of the BEI bei mode quantitation of the number of goldlabeled epitopes on cell surfaces cannot be achieved in the conventional AA electron mode of the sem but is an attractive possibility in the BEI mode" ], "offsets": [ [ 0, 816 ] ] } ]

[ { "id": "3467", "type": "abbreviation", "text": [ "BEI" ], "offsets": [ [ 808, 811 ] ], "normalized": [ { "db_name": "medal", "db_id": "backscattered electron imaging" } ] } ]

[]

[]

[]

[ { "id": "3469", "type": "PubMed abstract", "text": [ "in ALS als systems with bioregenerative components plant photosynthesis would be used to produce o and food while removing co much of the plant biomass would be inedible and hence must be considered in waste management this waste could be oxidized eg incinerated or aerobically digested to resupply co to the plants but this would not be needed unless the system were highly closed with regard to food for example in a partially closed system where some of the food is grown and some is imported co from Ox waste when combined with crew and microbial respiration could exceed the co removal capability of the plants moreover it would consume some o produced from photosynthesis that could have been used by the crew for partially closed systems it would be more appropriate to store or find other uses for the inedible biomass and excess carbon such as generating soils or growing woody plants eg dwarf fruit trees regardless of system closure high harvest crops ie crops with a high edible to total biomass ratio would increase food production per unit area and o yields for systems where waste biomass is oxidized to recycle co such interlinking effects between the plants and waste treatment strategies point out the importance of oxidizing only that amount of waste needed to optimize system performance" ], "offsets": [ [ 0, 1307 ] ] } ]

[ { "id": "3470", "type": "abbreviation", "text": [ "ALS" ], "offsets": [ [ 3, 6 ] ], "normalized": [ { "db_name": "medal", "db_id": "advanced life support" } ] } ]

[]

[]

[]

[ { "id": "3472", "type": "PubMed abstract", "text": [ "a mouse monoclonal antibody generated against drosophila intermediate filament proteins designated ah and referred to herein as ah is found to crossreact specifically with centrosomes in sea urchin eggs and with a kda antigen in eggs and isolated MI apparatus when S9 stained with ah are counterstained with a human autoimmune SS whose anticentrosome activity has been established the immunofluorescence images superimpose exactly a more severe test of the specificity of the antibody demands that it display all of the stages of the centrosome cycle in the Tc the flattening and spreading of the compact centrosomes followed by their division and the establishment of two compact poles the test was made by an experimental design that uses a period of SE of the eggs to mercaptoethanol this treatment allows observation of the stages of the centrosome cycleseparation division and bipolarizationwhile the chromosomes are arrested in metaphase mitosis is arrested in the presence of m mercaptoethanol chromosomes remain in a metaphase configuration while the centrosomes divide producing four poles perpendicular to the original spindle axis MTs are still present in the MA as indicated by immunofluorescence and transmission electron microscopy when mercaptoethanol is removed the chromosomes reorient to the poles of a tetrapolar sometimes tripolar MI apparatus during the following cycle the blastomeres form a MP mitotic apparatus the observations of the centrosome cycle with the ah antibody display very clearly all the stages that have been seen or deduced from work with other probes the kda antigen that reacts with the ah monoclonal antibody to drosophila intermediate filament proteins must be a constant component of sea urchin centrosomes because it is present at all stages of the centrosome cycle" ], "offsets": [ [ 0, 1811 ] ] } ]

[ { "id": "3473", "type": "abbreviation", "text": [ "MA" ], "offsets": [ [ 1171, 1173 ] ], "normalized": [ { "db_name": "medal", "db_id": "mitotic apparatus" } ] } ]

[]

[]

[]

[ { "id": "3475", "type": "PubMed abstract", "text": [ "this study evaluated the effect of peripheral injections of a beta adrenergic agonist brl on FI and whether this inhibition could be blocked by a nonspecific betaadrenergic antagonist propranolol given peripherally or into the CNS system when brl was injected intraperitoneally ip into lean and obese zucker rats food NI was decreased the reduction of FI by brl was attenuated when propranolol was po ip prior to giving the beta adrenergic agonist when propranolol was po into the third CBF ventricle it increased FI in lean rats but not the fatty rats propranolol administered into the third cerebral IVT att the effect on food NI of ip injection of brl these studies support the hypothesis that there are peripheral beta adrenergic receptors that can reduce FI and that there are central beta or beta adrenergic receptors that mediate the IP effect of the beta agonist" ], "offsets": [ [ 0, 870 ] ] } ]

[ { "id": "3476", "type": "abbreviation", "text": [ "FI" ], "offsets": [ [ 760, 762 ] ], "normalized": [ { "db_name": "medal", "db_id": "food intake" } ] } ]

[]

[]

[]

[ { "id": "3478", "type": "PubMed abstract", "text": [ "an excretorysecretory es antigen was extracted from supernatants of cell cultures infected with toxoplasma gondii purified and controlled according to current standards in volunteers the correlation with FL antibody was and no false positive skin tests were noted the skin test did not transform an originally negative serological test into a positive one for the prevention of congenital toxoplasmosis this sensitive specific and inexpensive skin test can be widely used for the detection of immunity to toxoplasma in women before their first pregnancy during pregnancy the PCD of specific igm is very important for the diagnosis of a recently acquired toxoplasmosis and allows for an immediate treatment for this PCD and for the diagnosis of CT five different serological tests were compared indirect fluorescent antibodytest ifa elisa test elisa test T3 capture of igm accas reverse enzyme immuno assay reia doublesandwich enzyme linked immunosorbent assay dselisa and immunosorbent agglutination CA isaga for sera of recently acquired toxoplasmosis igm were detected in with isaga in with dselisa and elisa in with reia and in with ifa test the best specificity is obtained with isaga dselisa and reia from controls with non immune patients cases patients with chronic toxoplasmosis sera RFs sera or antinuclear antibodies sera in sera from infants with CT isaga was positive in cases ifa in cases elisa and reia in cases and dselisa in cases abstract truncated at words" ], "offsets": [ [ 0, 1474 ] ] } ]

[ { "id": "3479", "type": "abbreviation", "text": [ "CT" ], "offsets": [ [ 744, 746 ] ], "normalized": [ { "db_name": "medal", "db_id": "congenital toxoplasmosis" } ] } ]

[]

[]

[]

[ { "id": "3481", "type": "PubMed abstract", "text": [ "the fusion oncoproteins tlschop and ewschop are characteristic markers for myxoid and round cell liposarcomas mlsrcls especially the peptide sequence of amino acids corresponding to the normally untranslated chop exon and parts of exon utr is a unique structure for these chimeric proteins in this report we have generated monoclonal antibodies against the unique peptide CS of tlsewschop oncoproteins these antibodies reacted with tlschop F0 protein but not reacted with normal tls and chop proteins by western blot analysis in addition one of the antibodies also recognized the chimeric oncoprotein in archival PET samples of mlsrcls the oncoprotein was detectable by the antibody even in the PET samples whose mrnas were too degraded to be detected by a nested reverse transcriptionpolymerase chain reactionbased CA thus the molecular assay using the novel antibody is expected to be one of the most CS diagnostic assays for mlsrcls" ], "offsets": [ [ 0, 935 ] ] } ]

[ { "id": "3482", "type": "abbreviation", "text": [ "PET" ], "offsets": [ [ 613, 616 ] ], "normalized": [ { "db_name": "medal", "db_id": "paraffinembedded tissue" } ] } ]

[]

[]

[]

[ { "id": "3484", "type": "PubMed abstract", "text": [ "the binding characteristics of [3H]NMS hnms to slidemounted tissue sections were studied using quantitative autoradiography binding of hnms was saturable reversible and of high affinity kd nm the inhibition of hnms IB produced by several muscarinic agonists and a additive histologic assessment aha patients were divided into three groups those who had uneventful operations and early postoperative periods but died prior to discharge those who had postoperative difficulty with identifiable acute anatomic causes of death and those who had postoperative difficulty with no apparent acute anatomic cause of death in group n the preoperative pulmonary arterial pressure was mm hg and aha ranged from to in group n the preoperative pulmonary arterial pressure was mm hg but aha ranged only from to in group n the preoperative pulmonary arterial pressure was mm hg aha ranged from to significantly higher than that of the other groups p less than three patients from group had elevated pulmonary arterial pressure and mm hg three six and days T3 surgery respectively two additional patients had RA heart failure with normally contracting left ventricles terminally it is concluded that some patients with mitral stenosis who die after surgery with persistently elevated pulmonary arterial pressure have sufficiently severe pulmonary V1 disease to account for their PPHN and death" ], "offsets": [ [ 0, 1376 ] ] } ]

[ { "id": "3485", "type": "abbreviation", "text": [ "[3H]NMS" ], "offsets": [ [ 31, 38 ] ], "normalized": [ { "db_name": "medal", "db_id": "nhmethylscopolamine" } ] } ]

[]

[]

[]

[ { "id": "3487", "type": "PubMed abstract", "text": [ "infertility is defined as the failure to achieve pregnancy after months or more of regular unprotected sexual intercourse one in six couples experience a delay in becoming pregnant in vitro fertilisation ivf is one of the assisted reproductive techniques used to enable couples to achieve a live birth one of the processes involved in ivf is embryo culture in an incubator where a stable environment is created and maintained the incubators are set at approximately °c which is based on the human CBT although several studies have shown that this temperature may in fact be lower in the female reproductive tract and that this could be beneficial in this review we have included RCT which compared different temperatures of embryo SC" ], "offsets": [ [ 0, 734 ] ] } ]

[ { "id": "3488", "type": "abbreviation", "text": [ "RCT" ], "offsets": [ [ 680, 683 ] ], "normalized": [ { "db_name": "medal", "db_id": "randomised controlled trials" } ] } ]

[]

[]

[]

[ { "id": "3490", "type": "PubMed abstract", "text": [ "recently we experienced AD postrenal transplantation cases with GD cytomegalic inclusion body in one case it was possible to carry out close endoscopic observation from onset to resolution a very rare opportunity a yearold man developed continuous occult blood in the stool for month T3 renal transplantation multiple erosive lesions from the upper corpus of the stomach to the bulb of the duodenum were revealed by the endoscopic study a biopsy specimen from the erosion showed the cytomegalic inclusion body one month later the erosive lesions had disappeared the second case is a yearold man who developed tarry stools days Tx multiple erosions partially covered with blood coagula from the upper portion of the gastric corpus to the antrum were revealed by the endoscopic examination a biopsy specimen from the erosion in the antrum contained the cytomegalic inclusion body" ], "offsets": [ [ 0, 877 ] ] } ]

[ { "id": "3491", "type": "abbreviation", "text": [ "GD" ], "offsets": [ [ 64, 66 ] ], "normalized": [ { "db_name": "medal", "db_id": "gastroduodenal" } ] } ]

[]

[]

[]

[ { "id": "3493", "type": "PubMed abstract", "text": [ "SH is a rare clinical manifestation of syphilis in this report a years old male patient who was diagnosed as secondary syphilis presenting with hepatitis has been discussed the patient was admitted to the hospital with high fever and skin rash and his PH revealed a suspected sexual contact he indicated that he had been admitted to a health center eight months ago because of the presence of a penile wound however vdrl VDRL was negative at that time fever degrees c jaundice in skin and sclera generalized macular and maculopapular skin rash including palms and soles lymphadenopathy and hepatosplenomegaly were detected in PE laboratory tests yielded elevated erythrocyte sedimantation rate high crp levels and elevated CL enzyme levels however VH markers together with vdrl and tpha treponema pallidum HA tests were found negative ceftriaxone therapy was initiated because of the presence of high fever degrees c and leukocytemm in urine and the absence of bacteria in gram IF of urine sample however the antibiotic therapy waslement we develop approximate methods for both our main problems that are simple to compute and have high efficiency application of these approximate methods to the whi study reveals statistically significant fat and breast cancer relationships when a fr is the instrument used and demonstrate a marginally significant advantage of the fr over the ffq in the local SP to detect such relationships" ], "offsets": [ [ 0, 1427 ] ] } ]

[ { "id": "3494", "type": "abbreviation", "text": [ "VDRL" ], "offsets": [ [ 421, 425 ] ], "normalized": [ { "db_name": "medal", "db_id": "venereal disease research laboratory test" } ] } ]

[]

[]

[]

[ { "id": "3496", "type": "PubMed abstract", "text": [ "popular stereotypes concerning the speech of homosexuals typically attribute speech patterns characteristic of the OS ie broadly feminized speech in gay men and broadly masculinized speech in lesbian women a small body of recent empirical research has begun to address the subject more systematically and to consider TPS mechanistic hypotheses to account for the potentially distinctive features of homosexual speech results do not yet fully endorse the stereotypes but they do not entirely discount them either nor do they cleanly favor any single mechanistic hypothesis to contribute to this growing body of research we report acoustic analyses of vowel sounds from a balanced set of speakers representing heterosexual and homosexual individuals of each sex from southern alberta canada analyses focused on voice pitch and formant frequencies which together determine the principle perceptual features of vowels there was no significant difference in mean voice pitch between heterosexual and homosexual men or between heterosexual and homosexual women but there were significant differences in the formant frequencies of vowels produced by both homosexual groups compared to their heterosexual counterparts formant frequency differences were specific to only certain vowel sounds and some could be attributed to basic differences in body size between heterosexual and homosexual speakers the remaining formant frequency differences were not obviously due to differences in vocal tract anatomy between heterosexual and homosexual speakers nor did they reflect global feminization or masculinization of vowel production patterns in homosexual men and women respectively the vowelspecific differences observed could reflect social modeling processes in which only certain speech patterns of the oppositesex or of samesex homosexuals are selectively adopted however we introduce an alternative biosocial hypothesis specifically that the distinctive vowelspecific features of homosexual speakers relative to heterosexual speakers arise incidentally as a product of broader psychobehavioral differences between the two CG that are in turn continuous with and flow from the physiological processes that affect sexual orientation to begin with" ], "offsets": [ [ 0, 2238 ] ] } ]

[ { "id": "3497", "type": "abbreviation", "text": [ "OS" ], "offsets": [ [ 115, 117 ] ], "normalized": [ { "db_name": "medal", "db_id": "oppositesex" } ] } ]

[]

[]

[]

[ { "id": "3499", "type": "PubMed abstract", "text": [ "mammogrambased classification is an important and ERP way for CAD cadbased breast cancer diagnosis in this paper we present a novel discriminant fusing analysis dfabased mammogram classification cadbased breast CA diagnosis the discriminative breast tissue features are exacted and fused by dfa and dfa achieves the optimal fusion coefficients the largest class discriminant in the fused feature space is achieved by dfa for classification beside the detailed theory derivation many exp evaluations are implemented on mammography image analysis society mammogram DB for breast CA diagnosis" ], "offsets": [ [ 0, 589 ] ] } ]

[ { "id": "3500", "type": "abbreviation", "text": [ "CAD" ], "offsets": [ [ 62, 65 ] ], "normalized": [ { "db_name": "medal", "db_id": "computeraided diagnosis" } ] } ]

[]

[]

[]

[ { "id": "3502", "type": "PubMed abstract", "text": [ "because of the characteristics of the parietal pericardial tissue the IN pericardial sac has a limited reserve volume becoming relatively noncompliant when the HV is at the high end of the normal physiologic range pericardial restraint of the HR is best considered as a contact force measured with flattened balloons the magnitude of pericardial contact pressure is probably several mmhg less than RA atrial pressure the diastolic pressurevolume relationship of the right IVT and to a lesser degree of the left ventricle shifts downward following pericardiectomy in dogs the pericardium has been shown to limit maximal cardiac SO some disease states associated with a rapid increase in total HV including subacute MR and right VVI infarction demonstrate an increased pericardial influence on cardiac filling" ], "offsets": [ [ 0, 807 ] ] } ]

[ { "id": "3503", "type": "abbreviation", "text": [ "HV" ], "offsets": [ [ 160, 162 ] ], "normalized": [ { "db_name": "medal", "db_id": "heart volume" } ] } ]

[]

[]

[]

[ { "id": "3505", "type": "PubMed abstract", "text": [ "in an attempt to categorize the diverse neurological manifestations of behçets syndrome a group of patients was prospectively studied the diagnosis of behçets syndrome was not known in any of them prior to their neurological presentation a reasonably clear distinction can be made to divide the manifestations into three GA categories with some overlap category i includes patients with increased intracranial pressure with or without cerebral A-V sinus thrombosis category ii are those presenting with a stroke category iii are those patients who present with spinal cord involvement and csf pleocytosis BS involvement was noted independently of the group in GA patients with neurobehçets syndrome showed little ocular involvement the course of the illness both in morbidity and mortality tended to be better in category i and mortality was only seen in category ii patients in populations susceptible to the disease the clinical categorisation proposed may alert the clinician to the possibility of neurobehçets syndrome whenever patients with pseudotumour cerebri DST stroke in the young unexplained myelitis or possible multiple sclerosis are encountered" ], "offsets": [ [ 0, 1162 ] ] } ]

[ { "id": "3506", "type": "abbreviation", "text": [ "DST" ], "offsets": [ [ 1071, 1074 ] ], "normalized": [ { "db_name": "medal", "db_id": "dural sinus thrombosis" } ] } ]

[]

[]

[]

[ { "id": "3508", "type": "PubMed abstract", "text": [ "a LM T0 of verrucous lesions with clinical features of seborrheic keratoses sk occurring on sunexposed skin of patients with EV ev was performed we observed the typical histological findings of sk in all cases in addition koilocytotic effects suggestive of ev were observed in the upper prickle layer and SG in lesions we also noted bowenoid changes suggesting possible early malignant transformation immunohistochemical study confirmed the presence of hpv in these lesions" ], "offsets": [ [ 0, 473 ] ] } ]

[ { "id": "3509", "type": "abbreviation", "text": [ "LM" ], "offsets": [ [ 2, 4 ] ], "normalized": [ { "db_name": "medal", "db_id": "light microscopic" } ] } ]

[]

[]

[]

[ { "id": "3511", "type": "PubMed abstract", "text": [ "SH a is spread by fecaloral transmission and accounts for of the cases of sporadic hepatitis in this country fatal cases have been documented but are unusual and chronic SH a has not been documented hepatitis b is spread by varied routes of transmission fecaloral being the least important and accounts for half the cases of sporadic SH in this country fatal cases are well documented and chronic SH b is common the only documented route of transmission of nona nonb hepatitis is parenteral fatal and chronic cases have been documented and a quarter of the cases of sporadic SH are nona nonb diagnosis of the etiology of VH cannot be determined on clinical grounds but must be made through serologic tests" ], "offsets": [ [ 0, 705 ] ] } ]

[ { "id": "3512", "type": "abbreviation", "text": [ "VH" ], "offsets": [ [ 621, 623 ] ], "normalized": [ { "db_name": "medal", "db_id": "viral hepatitis" } ] } ]

[]

[]

[]

[ { "id": "3514", "type": "PubMed abstract", "text": [ "copper amine oxidases utilize TPQ topaquinone as a cofactor in enzymatic catalysis this cofactor is formed from a IMT residue through a selfcatalytic mechanism with the participation of the copper ion at the AS site although pathways have been postulated for TPQ biogenesis portions of this scheme are still unclear we utilized tertbutylderived models for the putative intermediates of TPQ generation and studied the effect of cuii and znii ions on each autoxidative step from dopa to topaquinonelike EDC at physiological ph several polyvinylalcoholbased soluble resins bearing mono and dihydroxyphenolic moieties were also prepared and their tendency to give hydroxyquinonic structures when incubated at alkaline ph values was investigated our results confirm although indirectly the formation of dopa and dopaquinone during TPQ biosynthesis moreover we collected evidence that following the formation of dopa the role of the activesite copper ion in topaquinone biogenesis would be limited to the catalysis of the two subsequent quinonization steps ie from dopa to dopaquinone and from topa to TPQ thus disfavoring the possibility of a direct intervention of the metal ion in the hydroxylation of dopaquinone in particular cuii was shown to influence deeply the autoxidation of trihydroxytertbutylbenzene used as model of topa both increasing the reaction rate and changing its mechanism the mechanistic implications of these findings for the biogenesis of TPQ and its analogs at the AS site of various amine oxidases are discussed" ], "offsets": [ [ 0, 1533 ] ] } ]

[ { "id": "3515", "type": "abbreviation", "text": [ "TPQ" ], "offsets": [ [ 826, 829 ] ], "normalized": [ { "db_name": "medal", "db_id": "topaquinone" } ] } ]

[]

[]

[]

[ { "id": "3517", "type": "PubMed abstract", "text": [ "title xxi of the social security act the state CHIP chip was signed into law as part of the balanced budget PA in august the program provides billion to states over a fiveyear period to provide health insurance to uninsured children in lowwage working families with incomes too high to qualify for medicaid and too low to afford private coverage based on interviews with participating insurers in fall total enrollment of children in child health plus in onondaga county new york is approximately however there are still approximately uninsured and potentially eligible children in onondaga county in order to ensure the success of child health plus and enroll these uninsured children the state and county governments communities and plans participating in the program must be committed to effective outreach and ease of enrollment" ], "offsets": [ [ 0, 832 ] ] } ]

[ { "id": "3518", "type": "abbreviation", "text": [ "CHIP" ], "offsets": [ [ 47, 51 ] ], "normalized": [ { "db_name": "medal", "db_id": "childrens health insurance program" } ] } ]

[]

[]

[]

[ { "id": "3520", "type": "PubMed abstract", "text": [ "eightythree south indian PV were studied for hla antigen frequencies and compared with controls studied simultaneously hla bw a split of b was found elevated in the patients the two sexes differed in their ageatonset curves females had a preponderance to early ON of the disease while the males had late onset among these patients L1 group a western brachycephal armenoid group revealed the highest risk for b bw but not major group a mediterranean one" ], "offsets": [ [ 0, 452 ] ] } ]

[ { "id": "3521", "type": "abbreviation", "text": [ "PV" ], "offsets": [ [ 25, 27 ] ], "normalized": [ { "db_name": "medal", "db_id": "patients with psoriasis vulgaris" } ] } ]

[]

[]

[]

[ { "id": "3523", "type": "PubMed abstract", "text": [ "biodegradable sizing agents from TEA tea modified soy protein could substitute polyvinyl alcoholpva sizes for highspeed weaving of polyester and polyestercotton yarns to substantially decrease environmental pollution and impel sustainability of textile industry nonbiodegradable pva sizes are widely used and mainly contribute to high COD cod in textile effluents it has not been possible to effectively degrade reuse or replace pva sizes so far soy protein with good biodegradability showed potential as warp sizes in our previous studies however soy protein sizes lacked film flexibility and adhesion for required highspeed weaving additives with multiple hydroxyl CG nonlinear molecule and electric charge could physically modify AA structure of soy protein and lead to about and improvement in size adhesion and ability of hair coverage comparing to unmodified soy protein industrial weaving results showed teasoy protein had relative weaving efficiency and higher than pva and chemically modified starch sizes on polyestercotton fabrics and had relative weaving efficiency similar to pva on PET fabrics although with lower addon in addition teasoy sizes had a bodcod ratio of much higher than for pva indicating that teasoy sizes were easily biodegradable in activated sludge" ], "offsets": [ [ 0, 1280 ] ] } ]

[ { "id": "3524", "type": "abbreviation", "text": [ "PET" ], "offsets": [ [ 1096, 1099 ] ], "normalized": [ { "db_name": "medal", "db_id": "polyester" } ] } ]

[]

[]

[]

[ { "id": "3526", "type": "PubMed abstract", "text": [ "σ is a protein expressed in many epithelial tissues associated with essential cell functions including cellcycle control apoptosis and CSK integrity there is a paucity of knowledge of the tumorigenesis of canine RCCs rccs and the histological origin of this RT has not been established this T0 analyzed the expression of σ ki cytokeratins and vimentin in canine rccs aberrant expression of σ was demonstrated in cases and was associated with a significantly shorter survival time p in contrast to canine rcc normal kidney did not express σ the ki proliferation index did not show utility as a prognostic factor the distal convoluted tubular epithelium in NK coexpressed cytokeratins and vimentin and thus maintenance of this coexpression pattern in canine rcc suggests that most tumors arise from the distal segment of the nephron these results suggest that σ is a potential negative prognostic factor and a possible therapeutic target" ], "offsets": [ [ 0, 940 ] ] } ]

[ { "id": "3527", "type": "abbreviation", "text": [ "NK" ], "offsets": [ [ 659, 661 ] ], "normalized": [ { "db_name": "medal", "db_id": "normal kidneys" } ] } ]

[]

[]

[]

[ { "id": "3529", "type": "PubMed abstract", "text": [ "tissuespecific dysregulation of betahydroxysteroid dehydrogenase type betahsd activity in obese humans and animals may be associated with obesity and the metabolic syndrome we investigated the effect of inhibition of betahsd with GE ge an ERP betahsd inhibitor on body weight regulation in obese zucker rats which have a defect in the OB receptor gene ge mgkgd was administered in drinking water to weekold male zucker rats for weeks ge had no effect on FI or WG and did not affect hepatic betahsd and renal betahsd mrna levels in obese rats in contrast average daily FI and body weight on week were significantly reduced by ge in lean rats both p hepatic betahsd and renal betahsd mrna C2 were also significantly decreased by ge in lean rats both p ge had no significant effect on plasma corticosterone levels in obese rats but lowered them in lean rats p plasma leptin levels declined in both getreated obese and lean rats both p in conclusion longterm ge treatment decreased weight gain in lean zucker rats but not in obese zucker rats these findings suggest that the differing responses of betahsd to ge in obese and lean zucker rats are closely associated with the different weightgain responses furthermore the weightlowering effect of ge may require IN OB receptors" ], "offsets": [ [ 0, 1272 ] ] } ]

[ { "id": "3530", "type": "abbreviation", "text": [ "OB" ], "offsets": [ [ 1260, 1262 ] ], "normalized": [ { "db_name": "medal", "db_id": "leptin" } ] } ]

[]

[]

[]

[ { "id": "3532", "type": "PubMed abstract", "text": [ "PTM of intracellular proteins with olinked βnacetylglucosamine oglcnac profoundly affects protein structure function and metabolism although many skeletal muscle proteins are oglcnacylated the modification has not been extensively studied in this tissue especially in the context of exercise this study investigated the effects of glutathione SD and acute exercise on oglcnac protein modification in rat skeletal muscle DEM dem was used to deplete intracellular glutathione and rats were subjected to a treadmill run WG and soleus muscles were analyzed for glutathione status oglcnac and oglcnac GOT ogt protein levels and mrna expression of ogt oglcnacase and glutaminefructosephosphate amidotransferase dem and exercise both reduced intracellular glutathione and increased oglcnac dem upregulated ogt protein expression the effects of the interventions were significant h after exercise p the changes in the mrna levels of oglcnac enzymes were different in the two muscles potentially resulting from different rates of oxidative stress and metabolic demands between the muscle types these findings indicate that oxidative environment promotes oglcnacylation in skeletal muscle and suggest an interrelationship between cellular redox state and oglcnac protein modification this could represent one mechanism underlying cellular adaptation to oxidative stress and health benefits of exercise" ], "offsets": [ [ 0, 1392 ] ] } ]

[ { "id": "3533", "type": "abbreviation", "text": [ "WG" ], "offsets": [ [ 518, 520 ] ], "normalized": [ { "db_name": "medal", "db_id": "white gastrocnemius" } ] } ]

[]

[]

[]

[ { "id": "3535", "type": "PubMed abstract", "text": [ "kerrs hypothesis j comp neurol that chronic lesion of the lateral STT tract lstt might cause the ventral stt vstt to take over the nociceptive function of the lstt was tested electrophysiologically in cats recordings were made from antidromically identified deep stt cells in l months T3 lesion of the lstt at l confirming that these cells do not project rostrally in the lstt the receptive fields of deep stt cells were studied and found to be characteristic of these cells in normal animals they had not developed the nociceptive characteristics of lamina i stt cells immunohistochemistry showed that substance pcontaining afferents were still contained within the dorsal laminae of the l GM these results disprove kerrs hypothesis and suggest that STDP in other ascending systems must be responsible for the return of pain after lesion of the lstt" ], "offsets": [ [ 0, 850 ] ] } ]

[ { "id": "3536", "type": "abbreviation", "text": [ "STT" ], "offsets": [ [ 66, 69 ] ], "normalized": [ { "db_name": "medal", "db_id": "spinothalamic" } ] } ]

[]

[]

[]

[ { "id": "3538", "type": "PubMed abstract", "text": [ "the present T0 examined whether structural peculiarities in the brainefferent pathway to the organ of corti may underlie PET differences in hearing between pigmented and albino individuals of the same mammalian species pigmented brownnorway rats and albino WR received unilateral i.v. of an aqueous solution of the VA neuronal tracer fluorogold fg into the scala tympani of the cochlea to identify OC SN ocn in the brainstem SOC T3 five days brains were perfusionfixed and brainstem sections were cut and analyzed with respect to retrogradely labeled SN intrinsic SN of the lateral system were located exclusively in the ipsilateral lateral superior olive lso in both CG shell neurons surrounding the lso and in periolivary regions which made up only of all ocn were more often contralaterally located in albino than in pigmented animals a striking difference was observed in the laterality of neurons of the medial OC moc system which provided more than one third of all ocn these SN located in the rostral periolivary region and in the VP nucleus of the TB were observed CL to in pigmented and to in albino animals our study the first to compare the origin of the OCB in pigmented and albino rats provides evidence for differences in the crossing pattern of the olivocochlear pathway these were found predominantly in the moc system providing the direct efferent innervation of cochlear outer hair cells our findings may account for the alterations in auditory perception observed in albino mammals including man" ], "offsets": [ [ 0, 1514 ] ] } ]

[ { "id": "3539", "type": "abbreviation", "text": [ "TB" ], "offsets": [ [ 1056, 1058 ] ], "normalized": [ { "db_name": "medal", "db_id": "trapezoid body" } ] } ]

[]

[]

[]

[ { "id": "3541", "type": "PubMed abstract", "text": [ "the determination of the TPM tpm the ether extractable organic matter eeom and the polycyclic aromatic HCs pah in urban aerosols of berlinwedding and their biological testing ames test has shown that the concentrations of eeom and tpm are probably dependent on the wind direction whereas an influence of wind velocity and temperature cannot be stated on basis of our data in most cases the concentrations of eeom and tpm are higher on workdays than on weekends the concentration of eeom decreases from january till may the main portion of eeom and nearly all pah are concentrated in the smaller particles aerodynamic diameters less than micrometer the pah with four and less than four benzene nuclei show maximal concentrations on workdays whereas higher condensed pah show a maximum on weekends most of the etherextracts exhibits mutagenicity in the ames test extracts of the probably lung penetrating fractions and impactor stages mostly cause higher rates of mutation than those of the combined fractions main site of impaction nose and bronchi the highest rates of mutations are received with eeom from februarysamples" ], "offsets": [ [ 0, 1122 ] ] } ]

[ { "id": "3542", "type": "abbreviation", "text": [ "TPM" ], "offsets": [ [ 25, 28 ] ], "normalized": [ { "db_name": "medal", "db_id": "total particulate matter" } ] } ]

[]

[]

[]

[ { "id": "3544", "type": "PubMed abstract", "text": [ "there are controversial opinions about the effect of erupted second molars on distalization of the first molars most of the distalizing devices are anchored on the first molars without including second molars so differences between sequentially distalize maxillary molars second molar followed by the first molar or distalize second and first molars together are not clear the aim of the T0 was to compare sequential versus simultaneous molar distalization therapy with erupted M2 using two different modified pendulum appliances followed by fixed appliances" ], "offsets": [ [ 0, 558 ] ] } ]

[ { "id": "3545", "type": "abbreviation", "text": [ "M2" ], "offsets": [ [ 478, 480 ] ], "normalized": [ { "db_name": "medal", "db_id": "second molar" } ] } ]

[]

[]

[]

[ { "id": "3547", "type": "PubMed abstract", "text": [ "the previous studies have found a relationship between ia and both impulsivity and psychopathology when they were considered separately the aim of this T0 was to investigate the relationship of internet addiction ia with impulsivity and severity of psychopathology among turkish university students we also wanted to control the effect of impulsivity dimensions on the relationship between ia and psychopathology a total of university students from two universities in ankara participated to the study students were assessed through the internet addiction scale ias the symptom checklistrevised sclr and the barratt impulsiveness scale bis correlational analyses revealed that severity of ia was related to both sclr and bis scores among sclr subscales severity of OCS ocs was the only predictor for ias score hierarchical regression analysis indicated that interpersonal sensitivity additional to attentional and motor impulsiveness was the predictor of ias score although severity of ia is associated with wide range of psychopathology particularly ocs interpersonal sensitivity seems to be the main dimension that predict severity of ias additional to impulsiveness attentional and motor impulsivity seems to be an important construct when considering ia and its treatment among turkish university students" ], "offsets": [ [ 0, 1309 ] ] } ]

[ { "id": "3548", "type": "abbreviation", "text": [ "OCS" ], "offsets": [ [ 765, 768 ] ], "normalized": [ { "db_name": "medal", "db_id": "obsessivecompulsive symptoms" } ] } ]

[]

[]

[]

[ { "id": "3550", "type": "PubMed abstract", "text": [ "the female steroid hormone progesterone regulates ovulation and supports pregnancy but also controls human sperm CF within the FRT progesterone causes elevation of sperm intracellular ca leading to sperm hyperactivation acrosome reaction and perhaps chemotaxis toward the egg although it has been suggested that progesteronedependent ca influx into human spermatozoa is primarily mediated by cationic channel of sperm catsper the principal flagellar ca channel of sperm conclusive lossoffunction genetic evidence for activation of catsper by progesterone has yet to be provided moreover it is not clear whether the responsiveness of catsper to progesterone is an innate property of human spermatozoa or is acquired as the result of SE to the seminal plasma here by recording ionic currents from spermatozoa of an infertile catsperdeficient patient we demonstrate that catsper is indeed the principal ca channel of human spermatozoa and that it is strongly potentiated by progesterone in addition by recording catsper currents from human epididymal and testicular spermatozoa we show that catsper sensitivity to progesterone arises early in sperm OD and increases gradually to a peak when spermatozoa are ejaculated these results unambiguously establish an important role of catsper channel in human sperm nongenomic progesterone signaling and demonstrate that the molecular mechanism responsible for activation of catsper by progesterone arises early in sperm development concurrently with the catsper channel itself" ], "offsets": [ [ 0, 1516 ] ] } ]

[ { "id": "3551", "type": "abbreviation", "text": [ "FRT" ], "offsets": [ [ 127, 130 ] ], "normalized": [ { "db_name": "medal", "db_id": "female reproductive tract" } ] } ]

[]

[]

[]

[ { "id": "3553", "type": "PubMed abstract", "text": [ "humoral immune responses to the muc peptide and to mucrelated TF tf glycotope was investigated in patients with gastric cancer n chronic gastroduodenal diseases n and in healthy blood donors n data were correlated with disease type stage of CA tumor morphology and survival muc igg antibody levels were higher in patients with gastric cancer p than in healthy controls higher levels of antimuc igg were also detected in patients with ulcer of the stomach p and in atrophic gastritis p compared to blood donors significantly lower levels of antitf igg were found both in the cancer p and in the benign group p at early stages of cancer a positive rho p was found between muc igg and tf igg antibody levels high levels of tf EA were significantly associated with a benefit in survival of GC patients p a similar though weaker association was observed for patients with high levels of muc EA and locoregional disease stage iiii p thus igg immune responses to muc are increased in patients with GC high C2 of either tf igg or muc igg antibodies may predict better outcome in surgically treated patients with gastric CA" ], "offsets": [ [ 0, 1114 ] ] } ]

[ { "id": "3554", "type": "abbreviation", "text": [ "TF" ], "offsets": [ [ 62, 64 ] ], "normalized": [ { "db_name": "medal", "db_id": "thomsenfriedenreich" } ] } ]

[]

[]

[]

[ { "id": "3556", "type": "PubMed abstract", "text": [ "the objective of this T0 was to empirically disentangle role perceptions related to OCB ocb that have been confounded in past research investigate their unique relationships with both an affiliative helping and a challenging taking charge form of ocb and determine their relative importance in explaining these forms of ocb the authors also examined whether role discretion and role breadth independently moderate the procedural justicetoocb rf even the most affected feet" ], "offsets": [ [ 0, 472 ] ] } ]

[ { "id": "3557", "type": "abbreviation", "text": [ "OCB" ], "offsets": [ [ 84, 87 ] ], "normalized": [ { "db_name": "medal", "db_id": "organizational citizenship behavior" } ] } ]

[]

[]

[]

[ { "id": "3559", "type": "PubMed abstract", "text": [ "left VVI enddiastolic pressure lvedp is the foundation of cardiac function assessment because of difficulties and risks associated with its direct measurement correlates of lvedp derived by pulmonary i.a. pa catheterization or transesophageal echocardiography tee are commonly adopted tee has the advantage of being less invasive however teebased estimation of lvedp using correlates such as left ventricular EDV volume lvedv has technical difficulties that limit its clinical usefulness using intraoperative acute normovolemic hemodilution anh as a controlled hemorrhagic model we examined various MF parameters and threedimensional reconstructions of LAV as surrogates of lvedp our results demonstrate that peak e wave velocity and left atrial EDV volume laedv correlated with known changes in intravascular volume associated with anh although left atrial volumetric analysis was done offline in our study recent advances in echocardiographic software may allow for continuous display and RT calculation of laedv along with the ease and reproducibility of acquiring doppler images of flow across the mitral valve these two correlates of lvedp may justify a more widespread use of tee to optimize intraoperative fluid management the clinical applicability of peak e wave velocity and laedv still needs to be validated during uncontrolled resuscitation" ], "offsets": [ [ 0, 1352 ] ] } ]

[ { "id": "3560", "type": "abbreviation", "text": [ "MF" ], "offsets": [ [ 599, 601 ] ], "normalized": [ { "db_name": "medal", "db_id": "mitral flow" } ] } ]

[]

[]

[]

[ { "id": "3562", "type": "PubMed abstract", "text": [ "the metabolic fate of BDD bdd a AA metabolite of the industrial carcinogen butadiene is unclear the current T0 characterizes bdd oxidation to hydroxymethylvinyl ketone hmvk a reactive michael acceptor because of its instability in AQ medium hmvk was trapped by conjugation with gsh a reaction that occurred readily at physiological conditions ph degrees c to yield hydroxyketosglutathionylbutane the results show that bdd was oxidized to hmvk by mouse rat and human CL microsomes and by cdnaexpressed human cytochrome ps eadiehofstee plots demonstrated biphasic kinetics of bdd oxidation with mouse and rat liver microsomes and one of three individual human liver microsomes bdd oxidation by the other two human liver microsomal samples was best described by monophasic kinetics of the human p enzymes examined only p e exhibited activity at mm bdd p a was capable of catalyzing the reaction at a high bdd mm concentration p a a b dmet and dval produced only trace amounts of hmvkgsh whereas p a c c and a had no detectable activity detection of hmvk or the hmvkgsh conjugate was dependent on reaction time protein and bdd concentrations and the presence of nadph collectively the results provide clear evidence for bdd bioactivation to yield hmvk because mouse rat and human liver microsomes exhibited km values of microm the results also suggest that hmvk could be formed after rodent or human exposure to bdd or iation and healthcare service is recent and means that there are few data available at present CA mortality is lower among ethnic minority groups than the majority population in the uk which may partly be explained by a younger than average age within the ethnic minority CG and the fact that some members of ethnic CG retire to their country of origin however the mortality rates are expected to increase as the population ages breast and lung cancers are the most common cancers among ethnic minority CG in the uk traditional intervention strategies have been aimed at the majority white population and have not taken into account the needs identified by the ethnic communities themselves MI strategies include advice on stopping smoking and chewing tobacco increasing use of screening services by ethnic minority CG targeted HP messages and education on cancer specifically for these CG more data are required on CA among ethnic minority groups in the uk there are many similarities in the use of CA services between ethnic minority CG and individuals with lower socioeconomic status in the uk" ], "offsets": [ [ 0, 2511 ] ] } ]

[ { "id": "3563", "type": "abbreviation", "text": [ "BDD" ], "offsets": [ [ 22, 25 ] ], "normalized": [ { "db_name": "medal", "db_id": "butenediol" } ] } ]

[]

[]

[]

[ { "id": "3565", "type": "PubMed abstract", "text": [ "many methods for detecting MM GEMs gems in experimental ecosystems rely on cultivation of introduced cells in this T0 survival of escherichia coli was monitored with the green FL protein gfp gene this approach allowed enumeration of gems by both plating and microscopy use of the gfpmarked gems revealed that e coli persisted in stream water at higher densities as determined microscopically than as determined by cfu enumeration the gfp gene did not negatively impact the fitness of the host CS" ], "offsets": [ [ 0, 495 ] ] } ]

[ { "id": "3566", "type": "abbreviation", "text": [ "GEMs" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "medal", "db_id": "genetically engineered microorganisms" } ] } ]

[]

[]

[]

[ { "id": "3568", "type": "PubMed abstract", "text": [ "this T0 was designed to characterize the RS proteins as biomarkers of the normal aging process crossed immunoelectrophoresis or electroimmunodiffusion quantitation of proteins was performed in rats aged and mo selection of healthy animals was based on confrontation of crossed immunoelectrophoresis patterns with those of experimentally inflamed young adults and with individual anatomopathological data convergence of inflammatory patterns and severe histological lesions was the exclusion criterion senescenceinduced decrease was demonstrated for eight proteins negative senescence reactants srs and increase for six proteins positive srs srs most srs belonged to the class of proteins responsive to acute inflammation acute phase reactants aprs one sr the TBG a highaffinity thyroid hormone binder emerged as a particularly reliable senescence biomarker showing the highest agingrelated R2 fold increase from to mo and not belonging to the apr class chronic treatment with perindopril an angiotensin iconverting enzyme inhibitor used in HR and renal disease therapy significantly enhanced thyroxinebinding capacity possibly by preventing agerelated alterations of serum lipids serum protein patterns prove valuable both as indexes for selecting aging animals free from superimposed pathologies and as parameters of senescenceinduced changes in protein biosynthesis" ], "offsets": [ [ 0, 1367 ] ] } ]

[ { "id": "3569", "type": "abbreviation", "text": [ "TBG" ], "offsets": [ [ 759, 762 ] ], "normalized": [ { "db_name": "medal", "db_id": "thyroxinebinding globulin" } ] } ]

[]

[]

[]

[ { "id": "3571", "type": "PubMed abstract", "text": [ "in the presence of a molar excess of eukaryotic dna topoisomerase ii and an AGA concentration of dextran sulfate relaxed closed circular dna is converted to a negatively supercoiled form the reaction is dependent on atp neither adenosine betagammaimidotriphosphate nor adenosine gammathiotriphosphate can substitute for atp the negative supercoils formed are relaxed by subsequent addition of dna topoisomerase i to the supercoiling reaction mixture covalent closure of a nicked circular dna in the presence of dna topoisomerase ii and DS but in the absence of atp causes a small decrease in the linking number these results suggest that when an AGA concentration of DS is present the binding of a molar excess of eukaryotic dna topoisomerase ii constrains a small number of negative supercoils in dna which in turn generate unconstrained negative supercoils at the expense of atp" ], "offsets": [ [ 0, 880 ] ] } ]

[ { "id": "3572", "type": "abbreviation", "text": [ "DS" ], "offsets": [ [ 667, 669 ] ], "normalized": [ { "db_name": "medal", "db_id": "dextran sulfate" } ] } ]

[]

[]

[]

[ { "id": "3574", "type": "PubMed abstract", "text": [ "a frequently debated question for studies involving the measurement of stress hormones in rodents is the optimal method for collecting blood with minimal AS to the animal some investigators prefer the implantation of indwelling catheters to allow for frequent sampling others argue that the implantation of a catheter creates a chronic stress to the animal that confounds stress hormone measures and therefore rely on tail vein sampling moreover some investigators measure hormones in trunk blood samples obtained after anesthesia a practice that may itself raise hormone levels to address these controversies we compared plasma acth and corticosterone cort concentrations in pre and poststress rat blood samples obtained via previously implanted vena cava catheters tail vein nicks or clipping the tip off the tail and compared plasma acth and cort in rat blood samples obtained by decapitation with and without anesthesia rats sampled via indwelling catheters displayed lower prestress acth C2 than those sampled by tail vein nick if the time to acquire samples was not limited however elevated basal acth was not observed in samples obtained by tail clip or tail nick when the samples were obtained within min baseline cort C2 were similar in all groups after restraint AS the profile of the plasma acth and cort responses was not affected by sampling method decapitation with prior administration of co or PB increased plasma acth levels approximately and fold respectively when compared with decapitation without anesthesia these data indicate that tail vein nicking tail clipping or indwelling A-V catheters can be used for obtaining plasma for acth and cort during acute stress studies without confounding the measurements however the elevation in basal acth seen in the tail vein nick group at baseline suggests that sampling needs to be completed rapidly min to avoid the initiation of the PIT stress response death by co and PB i.t. before trunk blood collection cause significant stress to animals as reflected in the elevated plasma acth C2 these results support the use of either chronic V1 cannulas or sampling from a tail vein however collection of blood under pentobarbital sodium or co anesthesia is likely to confound the results of AS studies when acth is an important endpoint" ], "offsets": [ [ 0, 2296 ] ] } ]

[ { "id": "3575", "type": "abbreviation", "text": [ "PB" ], "offsets": [ [ 1935, 1937 ] ], "normalized": [ { "db_name": "medal", "db_id": "pentobarbital sodium" } ] } ]

[]

[]

[]

[ { "id": "3577", "type": "PubMed abstract", "text": [ "lipopolysaccharide lps a cell wall component of gram negative anaerobic bacteria has been implicated in the pathogenesis of periapical disease resulting from INF root canals calcium hydroxide caoh has been shown to be an ERP medicament in such infections reducing the microbial titre within the canal it has been proposed that the therapeutic effect of caoh may also be the result of direct inactivation of lps the aim of this T0 was to investigate whether the toxic potential of an escherichia coli lps could be reduced or eliminated by caoh four concentrations of e coli lps ranging from ngml sterile water were incubated in duplicate either with mg caoh or sterile water CT controls consisted of caoh without lps or sterile water only monocytes were collected from IP blood by centrifuging through a gradient and plated to a specific density Ad monocytes were incubated for days at degrees c with co in m medium with AS the different lps solutions were added to the wells on day T3 h the supernatants were collected and quantitatively assayed for TNF using a commercial elisa kit statistical analysis was performed with anova results indicated that caoh is able to eliminate the ability of an e coli lps to stimulate TNF production in peripheral blood monocytes p" ], "offsets": [ [ 0, 1266 ] ] } ]

[ { "id": "3578", "type": "abbreviation", "text": [ "AS" ], "offsets": [ [ 920, 922 ] ], "normalized": [ { "db_name": "medal", "db_id": "autologous serum" } ] } ]

[]

[]

[]

[ { "id": "3580", "type": "PubMed abstract", "text": [ "this paper compares the remineralization of human NK caries and artificial carieslike dentin lesions treated with a novel whiskerreinforced experimental CR art composite with a resinmodified GI rmgic as control ten molars with moderate NK dentin caries were prepared n artificial carieslike dentin lesions were prepared in occlusal dentin of cariesfree molars and demineralized at ph for h a the cavities were restored with art composite or rmgic all restored teeth were sliced into μm sections transverse microradiography combined with DIA was performed to analyze the NC in mineral density at the same position in the specimens before and after and weeks remineralizationdemineralization treatment the mean percent remineralization ± sigma T3 and weeks are n with art composite ± and ± respectively n with rmgic ± and ± respectively a with art composite ± and ± respectively a with rmgic ± and ± respectively there was a significant difference between the art composite and rmgic for the remineralization of NK caries p for both restoratives there were significant differences between the remineralization of NK and artificial caries p the art composite and rmgic remineralized natural and artificial caries differently most likely due to differences in the microstructure and composition of the caries dentin" ], "offsets": [ [ 0, 1321 ] ] } ]

[ { "id": "3581", "type": "abbreviation", "text": [ "CR" ], "offsets": [ [ 153, 155 ] ], "normalized": [ { "db_name": "medal", "db_id": "composite resin" } ] } ]

[]

[]

[]

[ { "id": "3583", "type": "PubMed abstract", "text": [ "PCD pcd is the genetically regulated disassembly of cells and occurs in the endosperm of cereals during seed maturation since pcd determines the lifetime of cells it can affect endosperm growth and therefore cereal yield however the features and mechanisms of pcd in the developing starchy endosperm in the poaceae remain unclear in the present study we investigated the characteristics of pcd in developing starchy endosperm of rice oryza sativa l by FM focusing on the spatial and temporal progress of pcdassociated responses cell death commenced in the central region of starchy endosperm and then spread to the IP region pcdassociated responses such as MMP and activation of the protease that cleaves the amino acid sequence veid showed similar spatial patterns to that of cell death but preceded cell death degradation of nuclear dna could not be detected in developing starchy endosperm by the tunel assay these results indicated that pcd in developing starchy endosperm of rice proceeds via a highly organized pattern in addition these results suggested that pcd in developing starchy endosperm of rice is characterized by the involvement of mitochondrial signaling and the activity of a caspaselike protease that cleaves the veid sequence" ], "offsets": [ [ 0, 1246 ] ] } ]

[ { "id": "3584", "type": "abbreviation", "text": [ "FM" ], "offsets": [ [ 452, 454 ] ], "normalized": [ { "db_name": "medal", "db_id": "fluorescence microscopy" } ] } ]

[]

[]

[]

[ { "id": "3586", "type": "PubMed abstract", "text": [ "regulating PCS size is an essential problem that biological organisms must solve from the subcellular to the organismal scales but it is not well understood what physical principles and mechanisms organisms use to sense and regulate their size any biophysical sizeregulation scheme operates in a noisy environment and must be robust to other cellular dynamics and fluctuations this work develops theory of filament length regulation inspired by recent experiments on kinesin motor proteins which move with directional bias on microtubule filaments and alter microtubule dynamics purified kinesin motors can depolymerize chemicallystabilized microtubules in the lengthdependent depolymerization model the rate of depolymerization tends to increase with filament length because long filaments accumulate more motors at their tips and therefore shorten more quickly when balanced with a constant filament growth rate this mechanism can lead to a fixed CP length however the mechanism by which kinesin motors affect the length of dynamic MTs in cells is less modes point aeration and step aeration were investigated under the same airsupply capacity oxygen dissolved more efficiently in the system with point aeration forming a larger aerobic zone the nitrifying effects were similar in point aeration and step aeration where the average removal efficiencies of nh n were and respectively when the proportion of anoxic and oxic zones was the average removal efficiencies of total nitrogen tn were and under point aeration and step aeration respectively step aeration was more beneficial to both anoxic denitrification and simultaneous nitrification and denitrification snd the maximum TPS ammoniauptake rates aur of point aeration and step aeration were and mg nhgmlvss h respectively while the maximum TPS nitriteuptake rates nur of the two systems were and mg nongmlvss h respectively the proportions of AOB aob to all bacteria were under point aeration and under step aeration and the proportions of nitriteoxidizing bacteria nob reached and under point and step aeration respectively the dominant genera of aob and nob were nitrosococcus and nitrospira which accounted for and respectively under point aeration and the diversity of nitrifying bacteria was lower than under step aeration point aeration was selective of nitrifying bacteria the abundance of nob was greater than that of aob in both of the T0 modes and CR transformation of nh n to non was observed without non accumulation" ], "offsets": [ [ 0, 2487 ] ] } ]

[ { "id": "3587", "type": "abbreviation", "text": [ "AOB" ], "offsets": [ [ 1902, 1905 ] ], "normalized": [ { "db_name": "medal", "db_id": "ammoniaoxidizing bacteria" } ] } ]

[]

[]

[]

[ { "id": "3589", "type": "PubMed abstract", "text": [ "data sourcescochrane oral healths trials register the cochrane CE register of controlled trials central medline embase cinahl ebsco cumulative index to nursing and allied health literature lilacs bireme virtual health library latin american and caribbean health science information database zetoc conference proceedings the us national institutes of health ongoing trials register clinicaltrialsgov and the world health organization international clinical trials registry platform for ongoing trials no restrictions were placed on the language or date of publication when searching the electronic databasesstudy selectionthe review included RCT irrespective of their language of publication or publication status participants could be outpatients or inpatients the review included trials comparing any pharmacological agent regimen prescribed prophylactically for SSG dysfunction prior to or during radiotherapy with PL no intervention or an alternative pharmacological MI comparisons of radiation techniques were excludeddata SE and synthesisstandard cochrane methodological processes were followedresultsthirtynine studies that randomised participants were included the number of participants analysed varied by outcome and time point the studies were ordered into separate comparisons with metaanalysis only being possible in three of those we found low SQ evidence to show that AMI when compared to a PL or no treatment control might reduce the risk of moderate to severe xerostomia grade or higher on a to scale at the end of radiotherapy risk ratio rr confidence interval ci to p three studies participants and up to three months after radiotherapy rr ci to p five studies participants but there is insufficient evidence that the effect is sustained up to months T3 radiotherapy rr ci to p seven studies participants we found very low quality evidence that AMI increased unstimulated salivary flow rate up to months T3 radiotherapy both in terms of mg of saliva per five T2 mean difference md ci to p one study participants and incidence of producing greater than g of saliva over five T2 rr ci to p one T0 participantshowever there was insufficient evidence to show a difference when looking at stimulated salivary flow rates there was insufficient very low quality evidence to show that amifostine compromised the effects of cancer treatment when looking at survival measures there was some very low quality evidence of a small benefit for AMI in terms of SQ of life tenpoint scale at months T3 radiotherapy md ci to p one study participants but insufficient evidence at the end of and up to threemonth post radiotherapy a further T0 showed no evidence of a difference at and month post radiotherapythere was low quality evidence that amifostine is associated with increases in vomiting rr ci to p five studies participants SH rr ci to p three studies participants nausea rr ci to p four studies participants and allergic response rr ci to p three studies participantsthe authors founded insufficient evidence that was of very low quality to determine whether or not pilocarpine performed better or worse than a placebo or no treatment control for the outcomes xerostomia salivary flow rate survival and SQ of life there was some low SQ evidence that pilocarpine was associated with an increase in sweating rr ci to p five studies participantsthe authors found insufficient evidence to determine whether or not palifermin performed better or worse than PL for xerostomia low quality survival moderate SQ and any adverse effects there was also insufficient evidence to determine the effects of the following interventions biperiden plus pilocarpine chinese medicines bethanechol AS Se antiseptic mouthrinse antimicrobial lozenge polaprezinc azulene rinse and venalot depot coumarin plus troxerutinconclusionsthere is some low SQ evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck with or without chemotherapy in the short end of radiotherapy to mediumterm threemonth post radiotherapy however it is less clear whether or not this effect is sustained to month post radiotherapy the benefits of amifostine should be weighed against its high cost and side effects there was insufficient evidence to show that any other intervention is beneficial" ], "offsets": [ [ 0, 4322 ] ] } ]

[ { "id": "3590", "type": "abbreviation", "text": [ "AMI" ], "offsets": [ [ 1863, 1866 ] ], "normalized": [ { "db_name": "medal", "db_id": "amifostine" } ] } ]

[]

[]

[]

[ { "id": "3592", "type": "PubMed abstract", "text": [ "the aim of this T0 was to estimate the allelic frequencies of the str loci included in the ampflstr identifiler pcr amplification kit in a sample of unrelated caucasian individuals autochthonous from spain to be used for forensic purposes and population studies the combined power of discrimination and the combined PE for all of the loci were x and respectively according to the obtained data the ds locus may be considered the most informative among the tested loci" ], "offsets": [ [ 0, 467 ] ] } ]

[ { "id": "3593", "type": "abbreviation", "text": [ "PE" ], "offsets": [ [ 316, 318 ] ], "normalized": [ { "db_name": "medal", "db_id": "power of exclusion" } ] } ]

[]

[]

[]

[ { "id": "3595", "type": "PubMed abstract", "text": [ "cbat and dbaj mice inoculated with plasmodium berghei anka pba develop CBF involvement days hpi from which the cba mice almost invariably die and the dba mice recover dexamethasone dxm mgkg given to inoculated cba mice twice on day and again within h reduced the CBF symptoms and prevented death from cerebral malaria plasma tumour CN factor tnf C2 which increased at the time of the cerebral symptoms were also reduced in these dxmtreated mice intravenously po evans blue a dye which binds to albumin diffused extensively across the bloodbrain barrier only during the period of CBF PS in proportion to the severity of the cerebral PS and the disease in pbainfected cba mice CBF PS and the amounts of evans blue diffusing into the brain tissue were both reduced by dxm treatment but only if the steroid was given on day and again within h endotoxin injected intravascularly into pbainfected dba mice T3 day resulted in an exaggeration of cerebral PS and death between days and plasma tnf and the amount of EB in the BB parenchyma increased above normal C2 in these mice endotoxin i.v. had only minor effects on the severity of the CBF symptoms in pbainfected cba mice and did not cause the animals to die sooner" ], "offsets": [ [ 0, 1211 ] ] } ]

[ { "id": "3596", "type": "abbreviation", "text": [ "EB" ], "offsets": [ [ 1006, 1008 ] ], "normalized": [ { "db_name": "medal", "db_id": "evans blue" } ] } ]

[]

[]

[]

[ { "id": "3598", "type": "PubMed abstract", "text": [ "a L1 pathogenic feature associated with hiv infection is lymphoid fibrosis which persists during antiretroviral therapy art NALT play critical roles in the generation of antigenspecific immune response and fibrosis disrupts the stromal network of lymphoid tissues resulting in impaired immune cell trafficking and function as well as immunodeficiency developing an animal model for investigating the impact of hiv infectioninduced LT fibrosis on immunodeficiency and immune cell impairment is critical for therapeutics development and clinical translation said MM will enable in vivo mechanistic studies thus complementing the wellestablished surrogate model of siv infectioninduced lymphoid tissue fibrosis in macaques we developed a potentially novel human immune systemhumanized mouse MM by coengrafting autologous FT SP and CL organoids under the kidney capsule along with iv injection of autologous fetal liverderived hematopoietic stem cells thus termed the bmliverthymusspleen blts humanized mouse model blts humanized mouse MM supports development of human immune cells and human lymphoid organoids human thymus and spleen organoids hiv infection in blts humanized mice results in progressive fibrosis in human lymphoid tissues which was associated with immunodeficiency in the NALT and LT fibrosis persists during art thus recapitulating clinical outcomes" ], "offsets": [ [ 0, 1364 ] ] } ]

[ { "id": "3599", "type": "abbreviation", "text": [ "FT" ], "offsets": [ [ 818, 820 ] ], "normalized": [ { "db_name": "medal", "db_id": "fetal thymus" } ] } ]

[]

[]

[]