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She was admitted following a fall and, after being given metoclopramide, developed movement disorder and a period of unresponsiveness.
|
[
{
"ade": "movement disorder",
"drug": "metoclopramide"
},
{
"ade": "unresponsiveness",
"drug": "metoclopramide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: She was admitted following a fall and, after being given metoclopramide, developed movement disorder and a period of unresponsiveness.",
"role": "user"
},
{
"content": "[{\"ade\": \"movement disorder\", \"drug\": \"metoclopramide\"}, {\"ade\": \"unresponsiveness\", \"drug\": \"metoclopramide\"}]",
"role": "assistant"
}
] |
From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).
|
[
{
"ade": "renal colic",
"drug": "indinavir"
},
{
"ade": "fever",
"drug": "indinavir"
},
{
"ade": "cutaneous rash",
"drug": "nelfinavir"
},
{
"ade": "nausea",
"drug": "efavirenz"
},
{
"ade": "temporary memory loss",
"drug": "efavirenz"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: From 1996 to 2002 several medications were changed due to their adverse effects: indinavir (renal colic and fever), nelfinavir (cutaneous rash), and efavirenz (nausea and temporary memory loss).",
"role": "user"
},
{
"content": "[{\"ade\": \"renal colic\", \"drug\": \"indinavir\"}, {\"ade\": \"fever\", \"drug\": \"indinavir\"}, {\"ade\": \"cutaneous rash\", \"drug\": \"nelfinavir\"}, {\"ade\": \"nausea\", \"drug\": \"efavirenz\"}, {\"ade\": \"temporary memory loss\", \"drug\": \"efavirenz\"}]",
"role": "assistant"
}
] |
A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.
|
[
{
"ade": "acute icteric hepatitis-like illness",
"drug": "gliclazide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 60-year-old woman with diabetes mellitus (type 2) developed an acute icteric hepatitis-like illness 6 weeks after the initiation of gliclazide therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute icteric hepatitis-like illness\", \"drug\": \"gliclazide\"}]",
"role": "assistant"
}
] |
DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.
|
[
{
"ade": "cardiomyopathy",
"drug": "Interferon alpha-2b"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.",
"role": "user"
},
{
"content": "[{\"ade\": \"cardiomyopathy\", \"drug\": \"Interferon alpha-2b\"}]",
"role": "assistant"
}
] |
Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.
|
[
{
"ade": "myopathy",
"drug": "colchicine"
},
{
"ade": "myopathy",
"drug": "statin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Both colchicine and statin therapy may be associated with myopathy, which usually occurs after several months of therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"myopathy\", \"drug\": \"colchicine\"}, {\"ade\": \"myopathy\", \"drug\": \"statin\"}]",
"role": "assistant"
}
] |
Fulminant hepatitis associated with disulfiram.
|
[
{
"ade": "Fulminant hepatitis",
"drug": "disulfiram"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Fulminant hepatitis associated with disulfiram.",
"role": "user"
},
{
"content": "[{\"ade\": \"Fulminant hepatitis\", \"drug\": \"disulfiram\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.
|
[
{
"ade": "Hypersensitivity reactions",
"drug": "cyclosporine"
},
{
"ade": "Hypersensitivity reactions",
"drug": "Cremophor EL"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: Hypersensitivity reactions to cyclosporine are due to Cremophor EL.",
"role": "user"
},
{
"content": "[{\"ade\": \"Hypersensitivity reactions\", \"drug\": \"cyclosporine\"}, {\"ade\": \"Hypersensitivity reactions\", \"drug\": \"Cremophor EL\"}]",
"role": "assistant"
}
] |
We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.
|
[
{
"ade": "pupillary mydriasis",
"drug": "lidocaine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present a neonate with a seizure disorder who acutely developed pupillary mydriasis secondary to lidocaine overdose.",
"role": "user"
},
{
"content": "[{\"ade\": \"pupillary mydriasis\", \"drug\": \"lidocaine\"}]",
"role": "assistant"
}
] |
Primary central nervous system lymphoma in a patient treated with natalizumab.
|
[
{
"ade": "Primary central nervous system lymphoma",
"drug": "natalizumab"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Primary central nervous system lymphoma in a patient treated with natalizumab.",
"role": "user"
},
{
"content": "[{\"ade\": \"Primary central nervous system lymphoma\", \"drug\": \"natalizumab\"}]",
"role": "assistant"
}
] |
Quetiapine-induced myoclonus.
|
[
{
"ade": "myoclonus",
"drug": "Quetiapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Quetiapine-induced myoclonus.",
"role": "user"
},
{
"content": "[{\"ade\": \"myoclonus\", \"drug\": \"Quetiapine\"}]",
"role": "assistant"
}
] |
Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.
|
[
{
"ade": "hepatotoxicity",
"drug": "imatinib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Up to four percent of patients treated with imatinib may develop hepatotoxicity, which usually resolves with discontinuation of the drug.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatotoxicity\", \"drug\": \"imatinib\"}]",
"role": "assistant"
}
] |
We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.
|
[
{
"ade": "hiccups",
"drug": "aripiprazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a patient of organic bipolar affective disorder who developed hiccups with the atypical antipsychotic aripiprazole.",
"role": "user"
},
{
"content": "[{\"ade\": \"hiccups\", \"drug\": \"aripiprazole\"}]",
"role": "assistant"
}
] |
Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.
|
[
{
"ade": "parkinsonism",
"drug": "Metoclopramide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Metoclopramide-induced parkinsonism is not rare, and appropriate dose reduction in patients with renal failure will help reduce the incidence of this morbidity.",
"role": "user"
},
{
"content": "[{\"ade\": \"parkinsonism\", \"drug\": \"Metoclopramide\"}]",
"role": "assistant"
}
] |
The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.
|
[
{
"ade": "worsening headache",
"drug": "penicillin"
},
{
"ade": "feeling cold",
"drug": "penicillin"
},
{
"ade": "chills",
"drug": "penicillin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The patient described feeling cold with worsening headache and chills approximately one hour after infusion of the first dose of penicillin.",
"role": "user"
},
{
"content": "[{\"ade\": \"worsening headache\", \"drug\": \"penicillin\"}, {\"ade\": \"feeling cold\", \"drug\": \"penicillin\"}, {\"ade\": \"chills\", \"drug\": \"penicillin\"}]",
"role": "assistant"
}
] |
We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.
|
[
{
"ade": "CD",
"drug": "etanercept"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.",
"role": "user"
},
{
"content": "[{\"ade\": \"CD\", \"drug\": \"etanercept\"}]",
"role": "assistant"
}
] |
PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.
|
[
{
"ade": "sudden bilateral, sequential visual loss",
"drug": "interferon alfa"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.",
"role": "user"
},
{
"content": "[{\"ade\": \"sudden bilateral, sequential visual loss\", \"drug\": \"interferon alfa\"}]",
"role": "assistant"
}
] |
Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.
|
[
{
"ade": "Anaphylactoid reaction",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.",
"role": "user"
},
{
"content": "[{\"ade\": \"Anaphylactoid reaction\", \"drug\": \"methylprednisolone\"}]",
"role": "assistant"
}
] |
Increasing the olanzapine dosage severely aggravated the symptoms of RLS.
|
[
{
"ade": "RLS",
"drug": "olanzapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Increasing the olanzapine dosage severely aggravated the symptoms of RLS.",
"role": "user"
},
{
"content": "[{\"ade\": \"RLS\", \"drug\": \"olanzapine\"}]",
"role": "assistant"
}
] |
An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.
|
[
{
"ade": "respiratory distress syndrome",
"drug": "Levemepromazine"
},
{
"ade": "respiratory distress syndrome",
"drug": "methotrimeprazine meleate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: An 11-year-old boy who was treated with a relatively high dose of methotrimeprazine meleate (Levemepromazine) a phenothiazine antipsychotic drug, was admitted to the pediatric intensive care unit suffering from respiratory distress syndrome.",
"role": "user"
},
{
"content": "[{\"ade\": \"respiratory distress syndrome\", \"drug\": \"Levemepromazine\"}, {\"ade\": \"respiratory distress syndrome\", \"drug\": \"methotrimeprazine meleate\"}]",
"role": "assistant"
}
] |
Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.
|
[
{
"ade": "Polyarthritis",
"drug": "rifampicin"
},
{
"ade": "Polyarthritis",
"drug": "ethambutol"
},
{
"ade": "anti-native DNA antibodies",
"drug": "ethambutol"
},
{
"ade": "hepatitis",
"drug": "ethambutol"
},
{
"ade": "hepatitis",
"drug": "rifampicin"
},
{
"ade": "anti-native DNA antibodies",
"drug": "rifampicin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Polyarthritis, hepatitis and anti-native DNA antibodies after treatment with ethambutol and rifampicin.",
"role": "user"
},
{
"content": "[{\"ade\": \"Polyarthritis\", \"drug\": \"rifampicin\"}, {\"ade\": \"Polyarthritis\", \"drug\": \"ethambutol\"}, {\"ade\": \"anti-native DNA antibodies\", \"drug\": \"ethambutol\"}, {\"ade\": \"hepatitis\", \"drug\": \"ethambutol\"}, {\"ade\": \"hepatitis\", \"drug\": \"rifampicin\"}, {\"ade\": \"anti-native DNA antibodies\", \"drug\": \"rifampicin\"}]",
"role": "assistant"
}
] |
CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.
|
[
{
"ade": "fixed drug eruption of the scrotum",
"drug": "methylphenidate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CASE SUMMARY: Two children with attention deficit disorder treated with methylphenidate as a simple drug developed fixed drug eruption of the scrotum.",
"role": "user"
},
{
"content": "[{\"ade\": \"fixed drug eruption of the scrotum\", \"drug\": \"methylphenidate\"}]",
"role": "assistant"
}
] |
Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.
|
[
{
"ade": "sedation",
"drug": "benzodiazepine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Flumazenil reversal of benzodiazepine-induced sedation for a patient with severe pre-ECT anxiety.",
"role": "user"
},
{
"content": "[{\"ade\": \"sedation\", \"drug\": \"benzodiazepine\"}]",
"role": "assistant"
}
] |
After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.
|
[
{
"ade": "supraventricular tachycardia",
"drug": "Partusisten"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: After treatment with a beta-sympathomimetic drug (Partusisten) one fetus developed supraventricular tachycardia.",
"role": "user"
},
{
"content": "[{\"ade\": \"supraventricular tachycardia\", \"drug\": \"Partusisten\"}]",
"role": "assistant"
}
] |
PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.
|
[
{
"ade": "respiratory depression",
"drug": "morphine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: PURPOSE: To present a case of respiratory depression following the administration of nebulised morphine.",
"role": "user"
},
{
"content": "[{\"ade\": \"respiratory depression\", \"drug\": \"morphine\"}]",
"role": "assistant"
}
] |
The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.
|
[
{
"ade": "diabetic ketoacidosis",
"drug": "perospirone hydrochloride"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The risk of new-onset diabetic ketoacidosis in patients with diabetic risk factors who are taking perospirone hydrochloride or other atypical antipsychotics should be kept in mind.",
"role": "user"
},
{
"content": "[{\"ade\": \"diabetic ketoacidosis\", \"drug\": \"perospirone hydrochloride\"}]",
"role": "assistant"
}
] |
In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.
|
[
{
"ade": "seizures",
"drug": "INH"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.",
"role": "user"
},
{
"content": "[{\"ade\": \"seizures\", \"drug\": \"INH\"}]",
"role": "assistant"
}
] |
Panic anxiety after abrupt discontinuation of mianserin.
|
[
{
"ade": "Panic anxiety",
"drug": "mianserin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Panic anxiety after abrupt discontinuation of mianserin.",
"role": "user"
},
{
"content": "[{\"ade\": \"Panic anxiety\", \"drug\": \"mianserin\"}]",
"role": "assistant"
}
] |
Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?
|
[
{
"ade": "acute interstitial nephritis",
"drug": "sunitinib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Biopsy-proven acute interstitial nephritis associated with the tyrosine kinase inhibitor sunitinib: a class effect?",
"role": "user"
},
{
"content": "[{\"ade\": \"acute interstitial nephritis\", \"drug\": \"sunitinib\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.
|
[
{
"ade": "thrombocytopenia",
"drug": "lansoprazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: Clinicians should be aware of the possible association of thrombocytopenia with lansoprazole and discontinue the drug if thrombocytopenia becomes apparent.",
"role": "user"
},
{
"content": "[{\"ade\": \"thrombocytopenia\", \"drug\": \"lansoprazole\"}]",
"role": "assistant"
}
] |
Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.
|
[
{
"ade": "Posterior leukoencephalopathy",
"drug": "vinblastine"
},
{
"ade": "Posterior leukoencephalopathy",
"drug": "cisplatin"
},
{
"ade": "Posterior leukoencephalopathy",
"drug": "bleomycin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Posterior leukoencephalopathy following cisplatin, bleomycin and vinblastine therapy for germ cell tumor of the ovary.",
"role": "user"
},
{
"content": "[{\"ade\": \"Posterior leukoencephalopathy\", \"drug\": \"vinblastine\"}, {\"ade\": \"Posterior leukoencephalopathy\", \"drug\": \"cisplatin\"}, {\"ade\": \"Posterior leukoencephalopathy\", \"drug\": \"bleomycin\"}]",
"role": "assistant"
}
] |
The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.
|
[
{
"ade": "maculopathy",
"drug": "chloroquine"
},
{
"ade": "maculopathy",
"drug": "hydroxychloroquine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.",
"role": "user"
},
{
"content": "[{\"ade\": \"maculopathy\", \"drug\": \"chloroquine\"}, {\"ade\": \"maculopathy\", \"drug\": \"hydroxychloroquine\"}]",
"role": "assistant"
}
] |
Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.
|
[
{
"ade": "wide QRS complex dysrhythmia",
"drug": "Propoxyphene"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.",
"role": "user"
},
{
"content": "[{\"ade\": \"wide QRS complex dysrhythmia\", \"drug\": \"Propoxyphene\"}]",
"role": "assistant"
}
] |
Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.
|
[
{
"ade": "severe hepatotoxic reactions",
"drug": "CPA"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Three male patients aged 78-83 years are presented, in whom severe hepatotoxic reactions emerged after CPA administration.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe hepatotoxic reactions\", \"drug\": \"CPA\"}]",
"role": "assistant"
}
] |
In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.
|
[
{
"ade": "decrease in blood lactate levels",
"drug": "DCA"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In one patient, treatment with DCA was associated with a decrease in blood lactate levels from 11.2 mM before treatment to 0.8 mM 16 h later.",
"role": "user"
},
{
"content": "[{\"ade\": \"decrease in blood lactate levels\", \"drug\": \"DCA\"}]",
"role": "assistant"
}
] |
However, recurrent staphylococcus aureus sepsis developed during CyA therapy.
|
[
{
"ade": "staphylococcus aureus sepsis",
"drug": "CyA"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: However, recurrent staphylococcus aureus sepsis developed during CyA therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"staphylococcus aureus sepsis\", \"drug\": \"CyA\"}]",
"role": "assistant"
}
] |
Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.
|
[
{
"ade": "Metabolic acidosis",
"drug": "chlorhexidine"
},
{
"ade": "Metabolic acidosis",
"drug": "cetrimide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Metabolic acidosis induced by cetrimide-chlorhexidine solution in hydatid cyst surgery.",
"role": "user"
},
{
"content": "[{\"ade\": \"Metabolic acidosis\", \"drug\": \"chlorhexidine\"}, {\"ade\": \"Metabolic acidosis\", \"drug\": \"cetrimide\"}]",
"role": "assistant"
}
] |
Nicotinic acid-induced fulminant hepatic failure.
|
[
{
"ade": "fulminant hepatic failure",
"drug": "Nicotinic acid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Nicotinic acid-induced fulminant hepatic failure.",
"role": "user"
},
{
"content": "[{\"ade\": \"fulminant hepatic failure\", \"drug\": \"Nicotinic acid\"}]",
"role": "assistant"
}
] |
Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.
|
[
{
"ade": "impaired tissue perfusion",
"drug": "vasopressin"
},
{
"ade": "vasodilation",
"drug": "vasopressin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.",
"role": "user"
},
{
"content": "[{\"ade\": \"impaired tissue perfusion\", \"drug\": \"vasopressin\"}, {\"ade\": \"vasodilation\", \"drug\": \"vasopressin\"}]",
"role": "assistant"
}
] |
This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.
|
[
{
"ade": "elevated serum triglyceride levels",
"drug": "clozapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This increase when clozapine was switched to risperidone and vice versa is consistent with our previous report of elevated serum triglyceride levels in clozapine-treated patients.",
"role": "user"
},
{
"content": "[{\"ade\": \"elevated serum triglyceride levels\", \"drug\": \"clozapine\"}]",
"role": "assistant"
}
] |
On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.
|
[
{
"ade": "acute respiratory distress",
"drug": "dalteparin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: On day 4, following 3 doses of dalteparin, the patient developed acute respiratory distress attributable to a massive right hemothorax confirmed by computed tomography pulmonary angiography (CTPA) and intercostal drainage of 1500 mL of frank blood.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute respiratory distress\", \"drug\": \"dalteparin\"}]",
"role": "assistant"
}
] |
Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor.
|
[
{
"ade": "Seizures",
"drug": "metrifonate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Seizures occurred in two patients with probable Alzheimer's disease who were receiving long-term treatment with metrifonate, an irreversible acetylcholinesterase inhibitor.",
"role": "user"
},
{
"content": "[{\"ade\": \"Seizures\", \"drug\": \"metrifonate\"}]",
"role": "assistant"
}
] |
Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.
|
[
{
"ade": "bipolar disorder",
"drug": "ritonavir"
},
{
"ade": "bipolar disorder",
"drug": "valproic Acid"
},
{
"ade": "bipolar disorder",
"drug": "lopinavir"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.",
"role": "user"
},
{
"content": "[{\"ade\": \"bipolar disorder\", \"drug\": \"ritonavir\"}, {\"ade\": \"bipolar disorder\", \"drug\": \"valproic Acid\"}, {\"ade\": \"bipolar disorder\", \"drug\": \"lopinavir\"}]",
"role": "assistant"
}
] |
Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.
|
[
{
"ade": "syndrome of inappropriate antidiuretic hormone",
"drug": "Cisplatin"
},
{
"ade": "SIADH",
"drug": "Cisplatin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with neuroendocrine tumor of the cervix: a case report and review of the literature.",
"role": "user"
},
{
"content": "[{\"ade\": \"syndrome of inappropriate antidiuretic hormone\", \"drug\": \"Cisplatin\"}, {\"ade\": \"SIADH\", \"drug\": \"Cisplatin\"}]",
"role": "assistant"
}
] |
Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.
|
[
{
"ade": "interstitial lung disease",
"drug": "sorafenib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.",
"role": "user"
},
{
"content": "[{\"ade\": \"interstitial lung disease\", \"drug\": \"sorafenib\"}]",
"role": "assistant"
}
] |
Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.
|
[
{
"ade": "precipitating psychosis",
"drug": "amantadine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.",
"role": "user"
},
{
"content": "[{\"ade\": \"precipitating psychosis\", \"drug\": \"amantadine\"}]",
"role": "assistant"
}
] |
Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.
|
[
{
"ade": "Intracranial hemorrhage",
"drug": "L-asparaginase"
},
{
"ade": "focal seizures",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Intracranial hemorrhage and focal seizures secondary to use of L-asparaginase during induction therapy of acute lymphocytic leukemia.",
"role": "user"
},
{
"content": "[{\"ade\": \"Intracranial hemorrhage\", \"drug\": \"L-asparaginase\"}, {\"ade\": \"focal seizures\", \"drug\": \"L-asparaginase\"}]",
"role": "assistant"
}
] |
METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.
|
[
{
"ade": "SS",
"drug": "risperidone"
},
{
"ade": "SS",
"drug": "divalproex sodium"
},
{
"ade": "SS",
"drug": "venlafaxine"
},
{
"ade": "NMS",
"drug": "carbamazepine"
},
{
"ade": "SS",
"drug": "topiramate"
},
{
"ade": "NMS",
"drug": "risperidone"
},
{
"ade": "NMS",
"drug": "venlafaxine"
},
{
"ade": "NMS",
"drug": "divalproex sodium"
},
{
"ade": "NMS",
"drug": "topiramate"
},
{
"ade": "SS",
"drug": "carbamazepine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",
"role": "user"
},
{
"content": "[{\"ade\": \"SS\", \"drug\": \"risperidone\"}, {\"ade\": \"SS\", \"drug\": \"divalproex sodium\"}, {\"ade\": \"SS\", \"drug\": \"venlafaxine\"}, {\"ade\": \"NMS\", \"drug\": \"carbamazepine\"}, {\"ade\": \"SS\", \"drug\": \"topiramate\"}, {\"ade\": \"NMS\", \"drug\": \"risperidone\"}, {\"ade\": \"NMS\", \"drug\": \"venlafaxine\"}, {\"ade\": \"NMS\", \"drug\": \"divalproex sodium\"}, {\"ade\": \"NMS\", \"drug\": \"topiramate\"}, {\"ade\": \"SS\", \"drug\": \"carbamazepine\"}]",
"role": "assistant"
}
] |
Acceleration of ventricular response to atrial flutter after intravenous adenosine.
|
[
{
"ade": "Acceleration of ventricular response",
"drug": "adenosine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acceleration of ventricular response to atrial flutter after intravenous adenosine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acceleration of ventricular response\", \"drug\": \"adenosine\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.
|
[
{
"ade": "sclerosing glomerulonephritis",
"drug": "Anastrozole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: Anastrozole may be the causative factor in patients with sclerosing glomerulonephritis.",
"role": "user"
},
{
"content": "[{\"ade\": \"sclerosing glomerulonephritis\", \"drug\": \"Anastrozole\"}]",
"role": "assistant"
}
] |
We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.
|
[
{
"ade": "porphyria cutanea tarda",
"drug": "cyclophosphamide"
},
{
"ade": "porphyria cutanea tarda",
"drug": "cisplatin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a 46-yr-old woman with ovarian carcinoma who developed porphyria cutanea tarda while undergoing treatment with cisplatin and cyclophosphamide.",
"role": "user"
},
{
"content": "[{\"ade\": \"porphyria cutanea tarda\", \"drug\": \"cyclophosphamide\"}, {\"ade\": \"porphyria cutanea tarda\", \"drug\": \"cisplatin\"}]",
"role": "assistant"
}
] |
METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.
|
[
{
"ade": "haematological adverse effects",
"drug": "quetiapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: METHOD: We describe three case-reports concerning haematological adverse effects of quetiapine.",
"role": "user"
},
{
"content": "[{\"ade\": \"haematological adverse effects\", \"drug\": \"quetiapine\"}]",
"role": "assistant"
}
] |
Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.
|
[
{
"ade": "Visual system side effects",
"drug": "botulinum toxin type B"
},
{
"ade": "parasympathetic dysfunction",
"drug": "botulinum toxin type B"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.",
"role": "user"
},
{
"content": "[{\"ade\": \"Visual system side effects\", \"drug\": \"botulinum toxin type B\"}, {\"ade\": \"parasympathetic dysfunction\", \"drug\": \"botulinum toxin type B\"}]",
"role": "assistant"
}
] |
After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.
|
[
{
"ade": "anisocoria",
"drug": "scopolamine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.",
"role": "user"
},
{
"content": "[{\"ade\": \"anisocoria\", \"drug\": \"scopolamine\"}]",
"role": "assistant"
}
] |
A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).
|
[
{
"ade": "raised creatine phosphokinase",
"drug": "propylthiouracil"
},
{
"ade": "severe proximal muscle weakness",
"drug": "propylthiouracil"
},
{
"ade": "hyperthyroidism",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A patient is presented with typical hyperthyroidism, who developed a severe proximal muscle weakness and a raised creatine phosphokinase after treatment for hyperthyroidism with propylthiouracil (100 mg orally, three times a day).",
"role": "user"
},
{
"content": "[{\"ade\": \"raised creatine phosphokinase\", \"drug\": \"propylthiouracil\"}, {\"ade\": \"severe proximal muscle weakness\", \"drug\": \"propylthiouracil\"}, {\"ade\": \"hyperthyroidism\", \"drug\": \"propylthiouracil\"}]",
"role": "assistant"
}
] |
This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.
|
[
{
"ade": "calcium phosphate nephrolithiasis",
"drug": "acetazolamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This sulfonamide like nephropathy should be differentiated from acetazolamide-related calcium phosphate nephrolithiasis.",
"role": "user"
},
{
"content": "[{\"ade\": \"calcium phosphate nephrolithiasis\", \"drug\": \"acetazolamide\"}]",
"role": "assistant"
}
] |
Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).
|
[
{
"ade": "Systemic capillary leak syndrome",
"drug": "granulocyte colony-stimulating factor"
},
{
"ade": "Systemic capillary leak syndrome",
"drug": "G-CSF"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).",
"role": "user"
},
{
"content": "[{\"ade\": \"Systemic capillary leak syndrome\", \"drug\": \"granulocyte colony-stimulating factor\"}, {\"ade\": \"Systemic capillary leak syndrome\", \"drug\": \"G-CSF\"}]",
"role": "assistant"
}
] |
However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.
|
[
{
"ade": "endometrial carcinoma",
"drug": "tamoxifen"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: However, in the mid-to-late 1980s, a series of letters to the editor and case reports announced an association between tamoxifen therapy in women with breast cancer and the development of endometrial carcinoma.",
"role": "user"
},
{
"content": "[{\"ade\": \"endometrial carcinoma\", \"drug\": \"tamoxifen\"}]",
"role": "assistant"
}
] |
The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.
|
[
{
"ade": "ischaemic events",
"drug": "venlafaxine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The association of venlafaxine treatment with ischaemic events could be explained by its unique pharmacological and haemodynamic properties.",
"role": "user"
},
{
"content": "[{\"ade\": \"ischaemic events\", \"drug\": \"venlafaxine\"}]",
"role": "assistant"
}
] |
Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.
|
[
{
"ade": "Peripheral neuropathy",
"drug": "amiodarone"
},
{
"ade": "cerebellar syndrome",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Peripheral neuropathy and cerebellar syndrome associated with amiodarone therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Peripheral neuropathy\", \"drug\": \"amiodarone\"}, {\"ade\": \"cerebellar syndrome\", \"drug\": \"amiodarone\"}]",
"role": "assistant"
}
] |
We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.
|
[
{
"ade": "ARDS",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "ARDS",
"drug": "pegIFNalpha-2a"
},
{
"ade": "ARDS",
"drug": "ribavirin"
},
{
"ade": "adult respiratory distress syndrome",
"drug": "ribavirin"
},
{
"ade": "adult respiratory distress syndrome",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "adult respiratory distress syndrome",
"drug": "pegIFNalpha-2a"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",
"role": "user"
},
{
"content": "[{\"ade\": \"ARDS\", \"drug\": \"pegylated interferon alpha-2a\"}, {\"ade\": \"ARDS\", \"drug\": \"pegIFNalpha-2a\"}, {\"ade\": \"ARDS\", \"drug\": \"ribavirin\"}, {\"ade\": \"adult respiratory distress syndrome\", \"drug\": \"ribavirin\"}, {\"ade\": \"adult respiratory distress syndrome\", \"drug\": \"pegylated interferon alpha-2a\"}, {\"ade\": \"adult respiratory distress syndrome\", \"drug\": \"pegIFNalpha-2a\"}]",
"role": "assistant"
}
] |
A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.
|
[
{
"ade": "lichen planus",
"drug": "gold"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold.",
"role": "user"
},
{
"content": "[{\"ade\": \"lichen planus\", \"drug\": \"gold\"}]",
"role": "assistant"
}
] |
We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.
|
[
{
"ade": "eruptive mollusca contagiosa",
"drug": "efalizumab"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a 45-year-old psoriasis patient who developed eruptive mollusca contagiosa during an antipsoriatic treatment with efalizumab.",
"role": "user"
},
{
"content": "[{\"ade\": \"eruptive mollusca contagiosa\", \"drug\": \"efalizumab\"}]",
"role": "assistant"
}
] |
Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.
|
[
{
"ade": "gastrointestinal bleeding",
"drug": "tolazoline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hypoxemia improved during continuous tolazoline infusion, but gastrointestinal bleeding occurred.",
"role": "user"
},
{
"content": "[{\"ade\": \"gastrointestinal bleeding\", \"drug\": \"tolazoline\"}]",
"role": "assistant"
}
] |
Additionally, danazol produces hepatocellular damage in approximately 10% of women.
|
[
{
"ade": "hepatocellular damage",
"drug": "danazol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Additionally, danazol produces hepatocellular damage in approximately 10% of women.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatocellular damage\", \"drug\": \"danazol\"}]",
"role": "assistant"
}
] |
Physicians using this "new" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.
|
[
{
"ade": "injury to the urinary tract",
"drug": "sulfonamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Physicians using this \"new\" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.",
"role": "user"
},
{
"content": "[{\"ade\": \"injury to the urinary tract\", \"drug\": \"sulfonamide\"}]",
"role": "assistant"
}
] |
Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.
|
[
{
"ade": "Acute myocardial infarction",
"drug": "L-thyroxine"
},
{
"ade": "coronary spasm",
"drug": "L-thyroxine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute myocardial infarction due to coronary spasm associated with L-thyroxine therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute myocardial infarction\", \"drug\": \"L-thyroxine\"}, {\"ade\": \"coronary spasm\", \"drug\": \"L-thyroxine\"}]",
"role": "assistant"
}
] |
We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.
|
[
{
"ade": "anaphylactic reaction",
"drug": "prednisone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe the case of a nonatopic 17-year-old girl with bronchial asthma and aspirin intolerance who developed a dramatic anaphylactic reaction to oral prednisone.",
"role": "user"
},
{
"content": "[{\"ade\": \"anaphylactic reaction\", \"drug\": \"prednisone\"}]",
"role": "assistant"
}
] |
We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.
|
[
{
"ade": "severe interstitial lung fibrosis",
"drug": "busulfan"
},
{
"ade": "severe interstitial lung fibrosis",
"drug": "melphalan"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe interstitial lung fibrosis\", \"drug\": \"busulfan\"}, {\"ade\": \"severe interstitial lung fibrosis\", \"drug\": \"melphalan\"}]",
"role": "assistant"
}
] |
Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.
|
[
{
"ade": "Severe visual loss",
"drug": "vincristine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Severe visual loss after a single dose of vincristine in a patient with spinal cord astrocytoma.",
"role": "user"
},
{
"content": "[{\"ade\": \"Severe visual loss\", \"drug\": \"vincristine\"}]",
"role": "assistant"
}
] |
Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.
|
[
{
"ade": "hypersensitivity",
"drug": "Carboplatin"
},
{
"ade": "hypersensitivity",
"drug": "carboplatin"
},
{
"ade": "hypersensitivity",
"drug": "paclitaxel"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Carboplatin hypersensitivity induced by low-dose paclitaxel/carboplatin in multiple platinum-treated patients with recurrent ovarian cancer.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypersensitivity\", \"drug\": \"Carboplatin\"}, {\"ade\": \"hypersensitivity\", \"drug\": \"carboplatin\"}, {\"ade\": \"hypersensitivity\", \"drug\": \"paclitaxel\"}]",
"role": "assistant"
}
] |
A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.
|
[
{
"ade": "seizures",
"drug": "interferon beta-1a"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 21-year-old man with Tourette's syndrome, pedophilia, Asperger's syndrome, and multiple sclerosis experienced seizures after receiving therapy with interferon beta-1a.",
"role": "user"
},
{
"content": "[{\"ade\": \"seizures\", \"drug\": \"interferon beta-1a\"}]",
"role": "assistant"
}
] |
When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.
|
[
{
"ade": "intense anxiety",
"drug": "lithium"
},
{
"ade": "neurotoxicity",
"drug": "lithium"
},
{
"ade": "psychotic symptoms",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: When the acute manic state is characterized by marked psychotic symptoms and intense anxiety, it may be associated with increased vulnerability to the development of severe lithium neurotoxicity.",
"role": "user"
},
{
"content": "[{\"ade\": \"intense anxiety\", \"drug\": \"lithium\"}, {\"ade\": \"neurotoxicity\", \"drug\": \"lithium\"}, {\"ade\": \"psychotic symptoms\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.
|
[
{
"ade": "general erythema",
"drug": "cisplatin"
},
{
"ade": "abdominal pain",
"drug": "cisplatin"
},
{
"ade": "dyspnea",
"drug": "cisplatin"
},
{
"ade": "fever",
"drug": "cisplatin"
},
{
"ade": "hypotension",
"drug": "cisplatin"
},
{
"ade": "hypersensitivity reactions",
"drug": "cisplatin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Two patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever.",
"role": "user"
},
{
"content": "[{\"ade\": \"general erythema\", \"drug\": \"cisplatin\"}, {\"ade\": \"abdominal pain\", \"drug\": \"cisplatin\"}, {\"ade\": \"dyspnea\", \"drug\": \"cisplatin\"}, {\"ade\": \"fever\", \"drug\": \"cisplatin\"}, {\"ade\": \"hypotension\", \"drug\": \"cisplatin\"}, {\"ade\": \"hypersensitivity reactions\", \"drug\": \"cisplatin\"}]",
"role": "assistant"
}
] |
The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.
|
[
{
"ade": "skin cancers",
"drug": "hydroxyurea"
},
{
"ade": "painful hand ulcer",
"drug": "hydroxyurea"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.",
"role": "user"
},
{
"content": "[{\"ade\": \"skin cancers\", \"drug\": \"hydroxyurea\"}, {\"ade\": \"painful hand ulcer\", \"drug\": \"hydroxyurea\"}]",
"role": "assistant"
}
] |
We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.
|
[
{
"ade": "symptomatic paroxysmal atrial fibrillation",
"drug": "vardenafil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.",
"role": "user"
},
{
"content": "[{\"ade\": \"symptomatic paroxysmal atrial fibrillation\", \"drug\": \"vardenafil\"}]",
"role": "assistant"
}
] |
Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.
|
[
{
"ade": "pleural effusion",
"drug": "dasatinib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although there have been numerous reports of effusions, none have provided complete pleural fluid analysis; therefore, we report 2 patients with dasatinib-induced pleural effusion with complete pleural fluid analysis.",
"role": "user"
},
{
"content": "[{\"ade\": \"pleural effusion\", \"drug\": \"dasatinib\"}]",
"role": "assistant"
}
] |
We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.
|
[
{
"ade": "cutaneous scleroderma",
"drug": "bleomycin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.",
"role": "user"
},
{
"content": "[{\"ade\": \"cutaneous scleroderma\", \"drug\": \"bleomycin\"}]",
"role": "assistant"
}
] |
A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam.
|
[
{
"ade": "acute psychosis",
"drug": "levetiracetam"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute psychosis\", \"drug\": \"levetiracetam\"}]",
"role": "assistant"
}
] |
Large dose of methylphenidate may cause cataract and glaucoma.
|
[
{
"ade": "glaucoma",
"drug": "methylphenidate"
},
{
"ade": "cataract",
"drug": "methylphenidate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Large dose of methylphenidate may cause cataract and glaucoma.",
"role": "user"
},
{
"content": "[{\"ade\": \"glaucoma\", \"drug\": \"methylphenidate\"}, {\"ade\": \"cataract\", \"drug\": \"methylphenidate\"}]",
"role": "assistant"
}
] |
Methotrexate is an effective but potentially toxic treatment for psoriasis.
|
[
{
"ade": "potentially toxic",
"drug": "Methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Methotrexate is an effective but potentially toxic treatment for psoriasis.",
"role": "user"
},
{
"content": "[{\"ade\": \"potentially toxic\", \"drug\": \"Methotrexate\"}]",
"role": "assistant"
}
] |
Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.
|
[
{
"ade": "Restless legs syndrome",
"drug": "IFN alpha"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Restless legs syndrome may thus be an adverse effect of IFN alpha treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"Restless legs syndrome\", \"drug\": \"IFN alpha\"}]",
"role": "assistant"
}
] |
We suggest that the previous classification of nitrofurantoin induced lung injury into "acute" and "chronic" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.
|
[
{
"ade": "nitrofurantoin induced lung injury",
"drug": "nitrofurantoin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We suggest that the previous classification of nitrofurantoin induced lung injury into \"acute\" and \"chronic\" injury is an oversimplification in view of the wide variety of pathological entities that have subsequently emerged.",
"role": "user"
},
{
"content": "[{\"ade\": \"nitrofurantoin induced lung injury\", \"drug\": \"nitrofurantoin\"}]",
"role": "assistant"
}
] |
Ezetimibe-induced acute pancreatitis.
|
[
{
"ade": "acute pancreatitis",
"drug": "Ezetimibe"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Ezetimibe-induced acute pancreatitis.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute pancreatitis\", \"drug\": \"Ezetimibe\"}]",
"role": "assistant"
}
] |
Acute pancreatitis after long-term 5-aminosalicylic acid therapy.
|
[
{
"ade": "Acute pancreatitis",
"drug": "5-aminosalicylic acid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute pancreatitis after long-term 5-aminosalicylic acid therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute pancreatitis\", \"drug\": \"5-aminosalicylic acid\"}]",
"role": "assistant"
}
] |
We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.
|
[
{
"ade": "fatal case of acute interstitial pneumonitis",
"drug": "carmustine"
},
{
"ade": "fatal case of acute interstitial pneumonitis",
"drug": "BCNU"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a fatal case of acute interstitial pneumonitis in a patient treated with carmustine (BCNU) for a brain tumor.",
"role": "user"
},
{
"content": "[{\"ade\": \"fatal case of acute interstitial pneumonitis\", \"drug\": \"carmustine\"}, {\"ade\": \"fatal case of acute interstitial pneumonitis\", \"drug\": \"BCNU\"}]",
"role": "assistant"
}
] |
Serious adverse events experienced by patients with chronic heart failure taking spironolactone.
|
[
{
"ade": "Serious adverse events",
"drug": "spironolactone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Serious adverse events experienced by patients with chronic heart failure taking spironolactone.",
"role": "user"
},
{
"content": "[{\"ade\": \"Serious adverse events\", \"drug\": \"spironolactone\"}]",
"role": "assistant"
}
] |
We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.
|
[
{
"ade": "torsades de pointes",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of recurrent torsades de pointes following treatment with pentavalent antimonial drugs and amiodarone.",
"role": "user"
},
{
"content": "[{\"ade\": \"torsades de pointes\", \"drug\": \"amiodarone\"}]",
"role": "assistant"
}
] |
We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.
|
[
{
"ade": "hypoglycaemia",
"drug": "mefloquine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of hypoglycaemia after mefloquine therapy (1,500 mg over two days) for severe gastrointestinal cryptosporidiasis in a cachectic AIDS patient with protracted diarrhoea.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypoglycaemia\", \"drug\": \"mefloquine\"}]",
"role": "assistant"
}
] |
An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.
|
[
{
"ade": "encephalopathy",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: An episode of subacute encephalopathy after the infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastic gastric cancer.",
"role": "user"
},
{
"content": "[{\"ade\": \"encephalopathy\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.
|
[
{
"ade": "granulomatous anterior uveitis",
"drug": "Metipranolol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.",
"role": "user"
},
{
"content": "[{\"ade\": \"granulomatous anterior uveitis\", \"drug\": \"Metipranolol\"}]",
"role": "assistant"
}
] |
Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.
|
[
{
"ade": "Cutaneous reactions",
"drug": "methimazole"
},
{
"ade": "Cutaneous reactions",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults.",
"role": "user"
},
{
"content": "[{\"ade\": \"Cutaneous reactions\", \"drug\": \"methimazole\"}, {\"ade\": \"Cutaneous reactions\", \"drug\": \"propylthiouracil\"}]",
"role": "assistant"
}
] |
Isoniazid causing breast tissue enlargement has been very rarely reported.
|
[
{
"ade": "breast tissue enlargement",
"drug": "Isoniazid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Isoniazid causing breast tissue enlargement has been very rarely reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"breast tissue enlargement\", \"drug\": \"Isoniazid\"}]",
"role": "assistant"
}
] |
Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.
|
[
{
"ade": "neurologic symptoms",
"drug": "Acyclovir"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acyclovir produces neurologic symptoms that resemble extension of viral infection into the central nervous system.",
"role": "user"
},
{
"content": "[{\"ade\": \"neurologic symptoms\", \"drug\": \"Acyclovir\"}]",
"role": "assistant"
}
] |
Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.
|
[
{
"ade": "dysrhythmia",
"drug": "Diphenhydramine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Diphenhydramine-induced wide complex dysrhythmia responds to treatment with sodium bicarbonate.",
"role": "user"
},
{
"content": "[{\"ade\": \"dysrhythmia\", \"drug\": \"Diphenhydramine\"}]",
"role": "assistant"
}
] |
Torsade de pointes during loading with amiodarone.
|
[
{
"ade": "Torsade de pointes",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Torsade de pointes during loading with amiodarone.",
"role": "user"
},
{
"content": "[{\"ade\": \"Torsade de pointes\", \"drug\": \"amiodarone\"}]",
"role": "assistant"
}
] |
Insulin-induced cardiac failure.
|
[
{
"ade": "cardiac failure",
"drug": "Insulin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Insulin-induced cardiac failure.",
"role": "user"
},
{
"content": "[{\"ade\": \"cardiac failure\", \"drug\": \"Insulin\"}]",
"role": "assistant"
}
] |
We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.
|
[
{
"ade": "CLS",
"drug": "granulocyte colony-stimulating factor"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present two cases in which both patients suffered with CLS, which we believe was caused following administration of granulocyte colony-stimulating factor, to our knowledge not described in the intensive care patient previously.",
"role": "user"
},
{
"content": "[{\"ade\": \"CLS\", \"drug\": \"granulocyte colony-stimulating factor\"}]",
"role": "assistant"
}
] |
The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.
|
[
{
"ade": "irreversible liver injury",
"drug": "troglitazone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The three reported cases demonstrate that troglitazone is an idiosyncratic hepatotoxin that can lead to irreversible liver injury.",
"role": "user"
},
{
"content": "[{\"ade\": \"irreversible liver injury\", \"drug\": \"troglitazone\"}]",
"role": "assistant"
}
] |
Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.
|
[
{
"ade": "PV",
"drug": "penicillamine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although the essential cause of PV is unclear, its onset has occasionally been associated with drug therapy, in particular penicillamine.",
"role": "user"
},
{
"content": "[{\"ade\": \"PV\", \"drug\": \"penicillamine\"}]",
"role": "assistant"
}
] |
Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.
|
[
{
"ade": "bitemporal visual field defects",
"drug": "ethambutol"
},
{
"ade": "decreased visual acuity",
"drug": "ethambutol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.",
"role": "user"
},
{
"content": "[{\"ade\": \"bitemporal visual field defects\", \"drug\": \"ethambutol\"}, {\"ade\": \"decreased visual acuity\", \"drug\": \"ethambutol\"}]",
"role": "assistant"
}
] |
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