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Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.
|
[
{
"ade": "pulmonary toxicity",
"drug": "Oxygen"
},
{
"ade": "pulmonary toxicity",
"drug": "bleomycin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Oxygen potentiation of bleomycin-induced pulmonary toxicity is discussed.",
"role": "user"
},
{
"content": "[{\"ade\": \"pulmonary toxicity\", \"drug\": \"Oxygen\"}, {\"ade\": \"pulmonary toxicity\", \"drug\": \"bleomycin\"}]",
"role": "assistant"
}
] |
Four cases of adverse experiences with clonidine are described.
|
[
{
"ade": "adverse experiences",
"drug": "clonidine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Four cases of adverse experiences with clonidine are described.",
"role": "user"
},
{
"content": "[{\"ade\": \"adverse experiences\", \"drug\": \"clonidine\"}]",
"role": "assistant"
}
] |
The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.
|
[
{
"ade": "stupor",
"drug": "valproate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The case of a 4-year-old girl with valproate-induced stupor and electroencephalographic pattern of increased fast activity is reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"stupor\", \"drug\": \"valproate\"}]",
"role": "assistant"
}
] |
Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.
|
[
{
"ade": "increased calcium-release",
"drug": "dihydrotachysterol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Immobilization, while Paget's bone disease was present, and perhaps enhanced activation of dihydrotachysterol by rifampicin, could have led to increased calcium-release into the circulation.",
"role": "user"
},
{
"content": "[{\"ade\": \"increased calcium-release\", \"drug\": \"dihydrotachysterol\"}]",
"role": "assistant"
}
] |
OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.
|
[
{
"ade": "nonthrombocytopenic palpable purpura",
"drug": "metoclopramide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: OBJECTIVE: To report a case of reversible nonthrombocytopenic palpable purpura associated with metoclopramide.",
"role": "user"
},
{
"content": "[{\"ade\": \"nonthrombocytopenic palpable purpura\", \"drug\": \"metoclopramide\"}]",
"role": "assistant"
}
] |
A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.
|
[
{
"ade": "hematochezia",
"drug": "warfarin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.",
"role": "user"
},
{
"content": "[{\"ade\": \"hematochezia\", \"drug\": \"warfarin\"}]",
"role": "assistant"
}
] |
Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.
|
[
{
"ade": "Hyponatremia",
"drug": "lorcainide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.",
"role": "user"
},
{
"content": "[{\"ade\": \"Hyponatremia\", \"drug\": \"lorcainide\"}]",
"role": "assistant"
}
] |
Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.
|
[
{
"ade": "Reversible posterior leukoencephalopathy syndrome",
"drug": "cyclosporine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Reversible posterior leukoencephalopathy syndrome in systemic lupus erythematosus with thrombocytopenia treated with cyclosporine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Reversible posterior leukoencephalopathy syndrome\", \"drug\": \"cyclosporine\"}]",
"role": "assistant"
}
] |
Trichiasis associated with prostaglandin analog use.
|
[
{
"ade": "Trichiasis",
"drug": "prostaglandin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Trichiasis associated with prostaglandin analog use.",
"role": "user"
},
{
"content": "[{\"ade\": \"Trichiasis\", \"drug\": \"prostaglandin\"}]",
"role": "assistant"
}
] |
Gemcitabine-related radiation recall in a patient with pancreatic cancer.
|
[
{
"ade": "radiation recall",
"drug": "Gemcitabine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Gemcitabine-related radiation recall in a patient with pancreatic cancer.",
"role": "user"
},
{
"content": "[{\"ade\": \"radiation recall\", \"drug\": \"Gemcitabine\"}]",
"role": "assistant"
}
] |
The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.
|
[
{
"ade": "keratitis",
"drug": "DCF"
},
{
"ade": "conjunctivitis",
"drug": "DCF"
},
{
"ade": "ocular toxicity",
"drug": "DCF"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The ocular toxicity of DCF, previously described as conjunctivitis, appears to be a keratitis of moderate severity which requires further study.",
"role": "user"
},
{
"content": "[{\"ade\": \"keratitis\", \"drug\": \"DCF\"}, {\"ade\": \"conjunctivitis\", \"drug\": \"DCF\"}, {\"ade\": \"ocular toxicity\", \"drug\": \"DCF\"}]",
"role": "assistant"
}
] |
We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.
|
[
{
"ade": "suicidal overdose deaths",
"drug": "quetiapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present three cases from the Provincial Toxicology Center of British Columbia, Canada in which suicidal overdose deaths were associated with quetiapine.",
"role": "user"
},
{
"content": "[{\"ade\": \"suicidal overdose deaths\", \"drug\": \"quetiapine\"}]",
"role": "assistant"
}
] |
This is the first report of pulmonary hypertension in an adult patient during lithium therapy.
|
[
{
"ade": "pulmonary hypertension",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This is the first report of pulmonary hypertension in an adult patient during lithium therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"pulmonary hypertension\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.
|
[
{
"ade": "agranulocytosis",
"drug": "quetiapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.",
"role": "user"
},
{
"content": "[{\"ade\": \"agranulocytosis\", \"drug\": \"quetiapine\"}]",
"role": "assistant"
}
] |
The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.
|
[
{
"ade": "hyperammonemia",
"drug": "valproate"
},
{
"ade": "mental status changes",
"drug": "valproate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.",
"role": "user"
},
{
"content": "[{\"ade\": \"hyperammonemia\", \"drug\": \"valproate\"}, {\"ade\": \"mental status changes\", \"drug\": \"valproate\"}]",
"role": "assistant"
}
] |
Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.
|
[
{
"ade": "Severe hepatotoxicity",
"drug": "benzarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.",
"role": "user"
},
{
"content": "[{\"ade\": \"Severe hepatotoxicity\", \"drug\": \"benzarone\"}]",
"role": "assistant"
}
] |
The cases of CBZ-induced SLE reported in the literature were reviewed.
|
[
{
"ade": "SLE",
"drug": "CBZ"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The cases of CBZ-induced SLE reported in the literature were reviewed.",
"role": "user"
},
{
"content": "[{\"ade\": \"SLE\", \"drug\": \"CBZ\"}]",
"role": "assistant"
}
] |
We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.
|
[
{
"ade": "hepatitis",
"drug": "riluzole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report the cases of two patients who developed acute hepatitis after taking riluzole at the recommended dose (100 mg daily) for 7 and 4 weeks, respectively.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatitis\", \"drug\": \"riluzole\"}]",
"role": "assistant"
}
] |
A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.
|
[
{
"ade": "metabolic acidosis",
"drug": "methazolamide"
},
{
"ade": "acute respiratory failure",
"drug": "Neptazane"
},
{
"ade": "acute respiratory failure",
"drug": "methazolamide"
},
{
"ade": "metabolic acidosis",
"drug": "Neptazane"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 60-year-old white man with chronic bronchitis was noted to develop acute respiratory failure and metabolic acidosis four days after being started on methazolamide (Neptazane) for an ophthalmologic problem.",
"role": "user"
},
{
"content": "[{\"ade\": \"metabolic acidosis\", \"drug\": \"methazolamide\"}, {\"ade\": \"acute respiratory failure\", \"drug\": \"Neptazane\"}, {\"ade\": \"acute respiratory failure\", \"drug\": \"methazolamide\"}, {\"ade\": \"metabolic acidosis\", \"drug\": \"Neptazane\"}]",
"role": "assistant"
}
] |
We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.
|
[
{
"ade": "systemic candidiasis",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe a patient with extranodal non-Hodgkin lymphoma who developed systemic candidiasis after treatment with a cyclophosphamide-based chemotherapy regimen.",
"role": "user"
},
{
"content": "[{\"ade\": \"systemic candidiasis\", \"drug\": \"cyclophosphamide\"}]",
"role": "assistant"
}
] |
These results indicate that lithium may cause biochemical hyperparathyroidism.
|
[
{
"ade": "biochemical hyperparathyroidism",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: These results indicate that lithium may cause biochemical hyperparathyroidism.",
"role": "user"
},
{
"content": "[{\"ade\": \"biochemical hyperparathyroidism\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.
|
[
{
"ade": "syncope",
"drug": "oxymetazoline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Are nasal decongestants safer than rhinitis? A case of oxymetazoline-induced syncope.",
"role": "user"
},
{
"content": "[{\"ade\": \"syncope\", \"drug\": \"oxymetazoline\"}]",
"role": "assistant"
}
] |
The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.
|
[
{
"ade": "cholelithiasis",
"drug": "cyclosporin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The use of cyclosporin has been associated with the development of cholelithiasis in transplant recipients.",
"role": "user"
},
{
"content": "[{\"ade\": \"cholelithiasis\", \"drug\": \"cyclosporin\"}]",
"role": "assistant"
}
] |
A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.
|
[
{
"ade": "apnoea",
"drug": "suxamethonium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A case of prolonged suxamethonium apnoea successfully terminated by the infusion of a commercial preparation of serumcholinesterase is reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"apnoea\", \"drug\": \"suxamethonium\"}]",
"role": "assistant"
}
] |
Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.
|
[
{
"ade": "anemia",
"drug": "enalapril"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Two renal transplant patients developed anemia during treatment of hypertension with enalapril medication.",
"role": "user"
},
{
"content": "[{\"ade\": \"anemia\", \"drug\": \"enalapril\"}]",
"role": "assistant"
}
] |
After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.
|
[
{
"ade": "psychotic reaction",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.",
"role": "user"
},
{
"content": "[{\"ade\": \"psychotic reaction\", \"drug\": \"methylprednisolone\"}]",
"role": "assistant"
}
] |
In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.
|
[
{
"ade": "cutaneous herpes zoster",
"drug": "cytarabine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.",
"role": "user"
},
{
"content": "[{\"ade\": \"cutaneous herpes zoster\", \"drug\": \"cytarabine\"}]",
"role": "assistant"
}
] |
Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.
|
[
{
"ade": "cardiotoxicity",
"drug": "diphenhydramine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although it would be expected that, like other type IA toxicities, diphenhydramine-induced cardiotoxicity could be responsive to hypertonic sodium bicarbonate, this finding is largely unappreciated.",
"role": "user"
},
{
"content": "[{\"ade\": \"cardiotoxicity\", \"drug\": \"diphenhydramine\"}]",
"role": "assistant"
}
] |
This is the first reported case of hepatolithiasis during octreotide therapy.
|
[
{
"ade": "hepatolithiasis",
"drug": "octreotide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This is the first reported case of hepatolithiasis during octreotide therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatolithiasis\", \"drug\": \"octreotide\"}]",
"role": "assistant"
}
] |
While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.
|
[
{
"ade": "abdominal pain",
"drug": "albendazole"
},
{
"ade": "worsening diarrhea",
"drug": "albendazole"
},
{
"ade": "fever",
"drug": "albendazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.",
"role": "user"
},
{
"content": "[{\"ade\": \"abdominal pain\", \"drug\": \"albendazole\"}, {\"ade\": \"worsening diarrhea\", \"drug\": \"albendazole\"}, {\"ade\": \"fever\", \"drug\": \"albendazole\"}]",
"role": "assistant"
}
] |
A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.
|
[
{
"ade": "lupus",
"drug": "infliximab"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A diagnosis of infliximab-induced lupus was made and the drug treatment was withdrawn.",
"role": "user"
},
{
"content": "[{\"ade\": \"lupus\", \"drug\": \"infliximab\"}]",
"role": "assistant"
}
] |
The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.
|
[
{
"ade": "nonconvulsive generalized status epilepticus",
"drug": "lorazepam"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The aim of this report is to describe the clinical and electroencephalographic findings seen in an elderly woman without previous history of seizures who developed a nonconvulsive generalized status epilepticus following acute withdrawal of lorazepam.",
"role": "user"
},
{
"content": "[{\"ade\": \"nonconvulsive generalized status epilepticus\", \"drug\": \"lorazepam\"}]",
"role": "assistant"
}
] |
Salicylate intoxication was excluded, and theophylline was finally incriminated.
|
[
{
"ade": "intoxication",
"drug": "theophylline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Salicylate intoxication was excluded, and theophylline was finally incriminated.",
"role": "user"
},
{
"content": "[{\"ade\": \"intoxication\", \"drug\": \"theophylline\"}]",
"role": "assistant"
}
] |
Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.
|
[
{
"ade": "lithium intoxication",
"drug": "lithium"
},
{
"ade": "diabetes insipidus-like syndrome",
"drug": "lithium"
},
{
"ade": "lithium intoxication",
"drug": "Lithium"
},
{
"ade": "diabetes insipidus-like syndrome",
"drug": "Lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Lithium treatment was terminated in 1975 because of lithium intoxication with a diabetes insipidus-like syndrome.",
"role": "user"
},
{
"content": "[{\"ade\": \"lithium intoxication\", \"drug\": \"lithium\"}, {\"ade\": \"diabetes insipidus-like syndrome\", \"drug\": \"lithium\"}, {\"ade\": \"lithium intoxication\", \"drug\": \"Lithium\"}, {\"ade\": \"diabetes insipidus-like syndrome\", \"drug\": \"Lithium\"}]",
"role": "assistant"
}
] |
A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.
|
[
{
"ade": "fever",
"drug": "carbimazole"
},
{
"ade": "sore throat",
"drug": "carbimazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.",
"role": "user"
},
{
"content": "[{\"ade\": \"fever\", \"drug\": \"carbimazole\"}, {\"ade\": \"sore throat\", \"drug\": \"carbimazole\"}]",
"role": "assistant"
}
] |
The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.
|
[
{
"ade": "amenorrhea",
"drug": "valproate"
},
{
"ade": "gained weight",
"drug": "valproate"
},
{
"ade": "polycystic changes",
"drug": "valproate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.",
"role": "user"
},
{
"content": "[{\"ade\": \"amenorrhea\", \"drug\": \"valproate\"}, {\"ade\": \"gained weight\", \"drug\": \"valproate\"}, {\"ade\": \"polycystic changes\", \"drug\": \"valproate\"}]",
"role": "assistant"
}
] |
Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.
|
[
{
"ade": "Acute myocardial infarction",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute myocardial infarction during high-dose methylprednisolone therapy for Graves' ophthalmopathy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute myocardial infarction\", \"drug\": \"methylprednisolone\"}]",
"role": "assistant"
}
] |
We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.
|
[
{
"ade": "stuttering",
"drug": "Warfarin"
},
{
"ade": "priapism",
"drug": "Warfarin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"stuttering\", \"drug\": \"Warfarin\"}, {\"ade\": \"priapism\", \"drug\": \"Warfarin\"}]",
"role": "assistant"
}
] |
Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.
|
[
{
"ade": "Alternating sinus rhythm",
"drug": "propranolol"
},
{
"ade": "intermittent sinoatrial (S-A) block",
"drug": "propranolol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Alternating sinus rhythm and intermittent sinoatrial (S-A) block was observed in a 57-year-old woman, under treatment for angina with 80 mg propranolol daily.",
"role": "user"
},
{
"content": "[{\"ade\": \"Alternating sinus rhythm\", \"drug\": \"propranolol\"}, {\"ade\": \"intermittent sinoatrial (S-A) block\", \"drug\": \"propranolol\"}]",
"role": "assistant"
}
] |
A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).
|
[
{
"ade": "complete heart block",
"drug": "disopyramide phosphate"
},
{
"ade": "complete heart block",
"drug": "Norpace"
},
{
"ade": "CHB",
"drug": "disopyramide phosphate"
},
{
"ade": "CHB",
"drug": "Norpace"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).",
"role": "user"
},
{
"content": "[{\"ade\": \"complete heart block\", \"drug\": \"disopyramide phosphate\"}, {\"ade\": \"complete heart block\", \"drug\": \"Norpace\"}, {\"ade\": \"CHB\", \"drug\": \"disopyramide phosphate\"}, {\"ade\": \"CHB\", \"drug\": \"Norpace\"}]",
"role": "assistant"
}
] |
We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.
|
[
{
"ade": "livedo reticularis",
"drug": "interferon alpha 2b"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report two patients who developed intense livedo reticularis clearly related to the administration of interferon alpha 2b as an adjuvant therapy for melanoma.",
"role": "user"
},
{
"content": "[{\"ade\": \"livedo reticularis\", \"drug\": \"interferon alpha 2b\"}]",
"role": "assistant"
}
] |
The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.
|
[
{
"ade": "proarrhythmic",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The probable proarrhythmic action of amiodarone, although rare, is reviewed along with a discussion of the novel use of intravenous magnesium sulfate therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"proarrhythmic\", \"drug\": \"amiodarone\"}]",
"role": "assistant"
}
] |
Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.
|
[
{
"ade": "extensive skin rash",
"drug": "MTX"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.",
"role": "user"
},
{
"content": "[{\"ade\": \"extensive skin rash\", \"drug\": \"MTX\"}]",
"role": "assistant"
}
] |
This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.
|
[
{
"ade": "MH",
"drug": "cresol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This case supports the assessment that MH and diabetes are associated diseases and that cresol could possibly trigger MH.",
"role": "user"
},
{
"content": "[{\"ade\": \"MH\", \"drug\": \"cresol\"}]",
"role": "assistant"
}
] |
Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.
|
[
{
"ade": "pellagra",
"drug": "Isoniazid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.",
"role": "user"
},
{
"content": "[{\"ade\": \"pellagra\", \"drug\": \"Isoniazid\"}]",
"role": "assistant"
}
] |
Patients treated with captopril who develop "atypical cholangitis" should be suspected of having captopril-associated liver damage.
|
[
{
"ade": "atypical cholangitis",
"drug": "captopril"
},
{
"ade": "liver damage",
"drug": "captopril"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Patients treated with captopril who develop \"atypical cholangitis\" should be suspected of having captopril-associated liver damage.",
"role": "user"
},
{
"content": "[{\"ade\": \"atypical cholangitis\", \"drug\": \"captopril\"}, {\"ade\": \"liver damage\", \"drug\": \"captopril\"}]",
"role": "assistant"
}
] |
We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.
|
[
{
"ade": "SJS",
"drug": "ciprofloxacin"
},
{
"ade": "VBDS",
"drug": "ciprofloxacin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature.",
"role": "user"
},
{
"content": "[{\"ade\": \"SJS\", \"drug\": \"ciprofloxacin\"}, {\"ade\": \"VBDS\", \"drug\": \"ciprofloxacin\"}]",
"role": "assistant"
}
] |
We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).
|
[
{
"ade": "cutaneous seeding",
"drug": "ethanol injection"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe a case of needle-track cutaneous seeding of hepatocellular carcinoma (HCC) after sonographically guided percutaneous ethanol injection (PEI).",
"role": "user"
},
{
"content": "[{\"ade\": \"cutaneous seeding\", \"drug\": \"ethanol injection\"}]",
"role": "assistant"
}
] |
Linear immunoglobulin A bullous dermatosis induced by gemcitabine.
|
[
{
"ade": "Linear immunoglobulin A bullous dermatosis",
"drug": "gemcitabine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Linear immunoglobulin A bullous dermatosis induced by gemcitabine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Linear immunoglobulin A bullous dermatosis\", \"drug\": \"gemcitabine\"}]",
"role": "assistant"
}
] |
DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.
|
[
{
"ade": "hyperlactatemia relapse",
"drug": "zidovudine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse.",
"role": "user"
},
{
"content": "[{\"ade\": \"hyperlactatemia relapse\", \"drug\": \"zidovudine\"}]",
"role": "assistant"
}
] |
Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.
|
[
{
"ade": "rhabdomyolysis",
"drug": "Clozapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.",
"role": "user"
},
{
"content": "[{\"ade\": \"rhabdomyolysis\", \"drug\": \"Clozapine\"}]",
"role": "assistant"
}
] |
OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.
|
[
{
"ade": "rhabdomyolysis",
"drug": "sertraline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: OBJECTIVE: To describe a case of sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.",
"role": "user"
},
{
"content": "[{\"ade\": \"rhabdomyolysis\", \"drug\": \"sertraline\"}]",
"role": "assistant"
}
] |
BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.
|
[
{
"ade": "Ovarian cancer",
"drug": "tamoxifen"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare.",
"role": "user"
},
{
"content": "[{\"ade\": \"Ovarian cancer\", \"drug\": \"tamoxifen\"}]",
"role": "assistant"
}
] |
A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.
|
[
{
"ade": "seizures",
"drug": "lorazepam"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 10-year-old girl with Lennox-Gastaut syndrome who received intravenous lorazepam for atypical absence status seizures is reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"seizures\", \"drug\": \"lorazepam\"}]",
"role": "assistant"
}
] |
To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.
|
[
{
"ade": "gastric LPD",
"drug": "MTX"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"gastric LPD\", \"drug\": \"MTX\"}]",
"role": "assistant"
}
] |
Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.
|
[
{
"ade": "leukoencephalopathy",
"drug": "Methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Methotrexate-induced leukoencephalopathy is treatable with high-dose folinic acid: a case report and analysis of the literature.",
"role": "user"
},
{
"content": "[{\"ade\": \"leukoencephalopathy\", \"drug\": \"Methotrexate\"}]",
"role": "assistant"
}
] |
The disease predisposes to severe vincristine neurotoxicity.
|
[
{
"ade": "vincristine neurotoxicity",
"drug": "vincristine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The disease predisposes to severe vincristine neurotoxicity.",
"role": "user"
},
{
"content": "[{\"ade\": \"vincristine neurotoxicity\", \"drug\": \"vincristine\"}]",
"role": "assistant"
}
] |
Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.
|
[
{
"ade": "psoriasis-like skin reaction",
"drug": "sulphasalazine"
},
{
"ade": "psoriasis-like skin reaction",
"drug": "SASP"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Presented is a case story of a woman with classical rheumatoid arthritis, who during introduction of sulphasalazine (SASP) therapy developed a severe and lasting psoriasis-like skin reaction.",
"role": "user"
},
{
"content": "[{\"ade\": \"psoriasis-like skin reaction\", \"drug\": \"sulphasalazine\"}, {\"ade\": \"psoriasis-like skin reaction\", \"drug\": \"SASP\"}]",
"role": "assistant"
}
] |
We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.
|
[
{
"ade": "severe demyelinating peripheral neuropathy",
"drug": "cytosine arabinoside"
},
{
"ade": "death",
"drug": "cytosine arabinoside"
},
{
"ade": "Horner's syndrome",
"drug": "cytosine arabinoside"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe a patient with acute leukemia who developed Horner's syndrome and a severe demyelinating peripheral neuropathy leading to death after receiving high-dose cytosine arabinoside.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe demyelinating peripheral neuropathy\", \"drug\": \"cytosine arabinoside\"}, {\"ade\": \"death\", \"drug\": \"cytosine arabinoside\"}, {\"ade\": \"Horner's syndrome\", \"drug\": \"cytosine arabinoside\"}]",
"role": "assistant"
}
] |
We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.
|
[
{
"ade": "eosinophilic cystitis",
"drug": "dimethyl sulfoxide"
},
{
"ade": "eosinophilic cystitis",
"drug": "DMSO"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.",
"role": "user"
},
{
"content": "[{\"ade\": \"eosinophilic cystitis\", \"drug\": \"dimethyl sulfoxide\"}, {\"ade\": \"eosinophilic cystitis\", \"drug\": \"DMSO\"}]",
"role": "assistant"
}
] |
Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.
|
[
{
"ade": "electrolyte disorders",
"drug": "Foscarnet"
},
{
"ade": "severe hypomagnesemia",
"drug": "Foscarnet"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Foscarnet-induced severe hypomagnesemia and other electrolyte disorders.",
"role": "user"
},
{
"content": "[{\"ade\": \"electrolyte disorders\", \"drug\": \"Foscarnet\"}, {\"ade\": \"severe hypomagnesemia\", \"drug\": \"Foscarnet\"}]",
"role": "assistant"
}
] |
Cephalexin rash in infectious mononucleosis.
|
[
{
"ade": "Cephalexin rash",
"drug": "Cephalexin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cephalexin rash in infectious mononucleosis.",
"role": "user"
},
{
"content": "[{\"ade\": \"Cephalexin rash\", \"drug\": \"Cephalexin\"}]",
"role": "assistant"
}
] |
We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.
|
[
{
"ade": "morbidity",
"drug": "hyperbaric oxygen"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.",
"role": "user"
},
{
"content": "[{\"ade\": \"morbidity\", \"drug\": \"hyperbaric oxygen\"}]",
"role": "assistant"
}
] |
Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.
|
[
{
"ade": "Dyspnea",
"drug": "rituximab"
},
{
"ade": "pleuritic chest pain",
"drug": "rituximab"
},
{
"ade": "hypoxemia",
"drug": "rituximab"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Dyspnea, hypoxemia, and pleuritic chest pain occurred within 24 hours of rituximab administration, and there was no other apparent explanation.",
"role": "user"
},
{
"content": "[{\"ade\": \"Dyspnea\", \"drug\": \"rituximab\"}, {\"ade\": \"pleuritic chest pain\", \"drug\": \"rituximab\"}, {\"ade\": \"hypoxemia\", \"drug\": \"rituximab\"}]",
"role": "assistant"
}
] |
Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.
|
[
{
"ade": "hyperglycemia",
"drug": "insulin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.",
"role": "user"
},
{
"content": "[{\"ade\": \"hyperglycemia\", \"drug\": \"insulin\"}]",
"role": "assistant"
}
] |
Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.
|
[
{
"ade": "Toxic hepatitis",
"drug": "methotrexate"
},
{
"ade": "Toxic hepatitis",
"drug": "etretinate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.",
"role": "user"
},
{
"content": "[{\"ade\": \"Toxic hepatitis\", \"drug\": \"methotrexate\"}, {\"ade\": \"Toxic hepatitis\", \"drug\": \"etretinate\"}]",
"role": "assistant"
}
] |
The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.
|
[
{
"ade": "liver dysfunction",
"drug": "Lp-TAE"
},
{
"ade": "low-grade fever",
"drug": "Lp-TAE"
},
{
"ade": "localized pain",
"drug": "Lp-TAE"
},
{
"ade": "myelo-suppression",
"drug": "Lp-TAE"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.",
"role": "user"
},
{
"content": "[{\"ade\": \"liver dysfunction\", \"drug\": \"Lp-TAE\"}, {\"ade\": \"low-grade fever\", \"drug\": \"Lp-TAE\"}, {\"ade\": \"localized pain\", \"drug\": \"Lp-TAE\"}, {\"ade\": \"myelo-suppression\", \"drug\": \"Lp-TAE\"}]",
"role": "assistant"
}
] |
Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.
|
[
{
"ade": "severe hepatic necrosis",
"drug": "paracetamol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe hepatic necrosis\", \"drug\": \"paracetamol\"}]",
"role": "assistant"
}
] |
Cutaneous eruptions occur in 3% of individuals administered carbamazepine.
|
[
{
"ade": "Cutaneous eruptions",
"drug": "carbamazepine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cutaneous eruptions occur in 3% of individuals administered carbamazepine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Cutaneous eruptions\", \"drug\": \"carbamazepine\"}]",
"role": "assistant"
}
] |
We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.
|
[
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a patient who developed heparin associated thrombocytopenia during continuous arteriovenous haemofiltration and discuss its implications and alternative anticoagulant treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"thrombocytopenia\", \"drug\": \"heparin\"}]",
"role": "assistant"
}
] |
Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.
|
[
{
"ade": "Transfusion haemosiderosis",
"drug": "desferrioxamine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Transfusion haemosiderosis inspite of regular use of desferrioxamine: case report.",
"role": "user"
},
{
"content": "[{\"ade\": \"Transfusion haemosiderosis\", \"drug\": \"desferrioxamine\"}]",
"role": "assistant"
}
] |
Troglitazone-induced fulminant hepatic failure.
|
[
{
"ade": "fulminant hepatic failure",
"drug": "Troglitazone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Troglitazone-induced fulminant hepatic failure.",
"role": "user"
},
{
"content": "[{\"ade\": \"fulminant hepatic failure\", \"drug\": \"Troglitazone\"}]",
"role": "assistant"
}
] |
Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.
|
[
{
"ade": "Fatal interstitial pneumonitis",
"drug": "chlorambucil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Fatal interstitial pneumonitis following high-dose intermittent chlorambucil therapy for chronic lymphocyte leukemia.",
"role": "user"
},
{
"content": "[{\"ade\": \"Fatal interstitial pneumonitis\", \"drug\": \"chlorambucil\"}]",
"role": "assistant"
}
] |
A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.
|
[
{
"ade": "dysphagia for solids",
"drug": "nifedipine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 57-year-old woman presented with a 3-week history of dysphagia for solids, 6 months after starting treatment with nifedipine.",
"role": "user"
},
{
"content": "[{\"ade\": \"dysphagia for solids\", \"drug\": \"nifedipine\"}]",
"role": "assistant"
}
] |
Photo-onycholysis caused by olanzapine and aripiprazole.
|
[
{
"ade": "Photo-onycholysis",
"drug": "olanzapine"
},
{
"ade": "Photo-onycholysis",
"drug": "aripiprazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Photo-onycholysis caused by olanzapine and aripiprazole.",
"role": "user"
},
{
"content": "[{\"ade\": \"Photo-onycholysis\", \"drug\": \"olanzapine\"}, {\"ade\": \"Photo-onycholysis\", \"drug\": \"aripiprazole\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.
|
[
{
"ade": "allergic reactions",
"drug": "capecitabine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: The use of fluorouracil treatment with careful monitoring can be considered in a patient with mild allergic reactions to capecitabine.",
"role": "user"
},
{
"content": "[{\"ade\": \"allergic reactions\", \"drug\": \"capecitabine\"}]",
"role": "assistant"
}
] |
After stopping indapamide, glucose tolerance impairing may be reversed.
|
[
{
"ade": "glucose tolerance impairing",
"drug": "indapamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: After stopping indapamide, glucose tolerance impairing may be reversed.",
"role": "user"
},
{
"content": "[{\"ade\": \"glucose tolerance impairing\", \"drug\": \"indapamide\"}]",
"role": "assistant"
}
] |
We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.
|
[
{
"ade": "EPS",
"drug": "clozapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present a surprising case of a woman schizophrenic patient treated with clozapine suffering from EPS.",
"role": "user"
},
{
"content": "[{\"ade\": \"EPS\", \"drug\": \"clozapine\"}]",
"role": "assistant"
}
] |
We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.
|
[
{
"ade": "acute cerebellar syndrome",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe a patient who developed acute cerebellar syndrome after prophylactic intrathecal methotrexate administration and recovered spontaneously.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute cerebellar syndrome\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.
|
[
{
"ade": "acute dystonia",
"drug": "pegylated interferon alpha"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In this case report, we present clinical and laboratory findings of a case with chronic hepatitis B that developed acute dystonia soon after the first dose of pegylated interferon alpha.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute dystonia\", \"drug\": \"pegylated interferon alpha\"}]",
"role": "assistant"
}
] |
Ifosfamide-associated neurotoxicity was noted within hours of drug administration and improved rapidly following hemodialysis.
|
[
{
"ade": "neurotoxicity",
"drug": "Ifosfamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Ifosfamide-associated neurotoxicity was noted within hours of drug administration and improved rapidly following hemodialysis.",
"role": "user"
},
{
"content": "[{\"ade\": \"neurotoxicity\", \"drug\": \"Ifosfamide\"}]",
"role": "assistant"
}
] |
A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.
|
[
{
"ade": "transaminitis",
"drug": "sulfadiazine"
},
{
"ade": "fever",
"drug": "pyrimethamine"
},
{
"ade": "fever",
"drug": "sulfadiazine"
},
{
"ade": "swelling",
"drug": "sulfadiazine"
},
{
"ade": "abdominal pain",
"drug": "pyrimethamine"
},
{
"ade": "transaminitis",
"drug": "pyrimethamine"
},
{
"ade": "abdominal pain",
"drug": "sulfadiazine"
},
{
"ade": "swelling",
"drug": "pyrimethamine"
},
{
"ade": "severe cutaneous involvement",
"drug": "pyrimethamine"
},
{
"ade": "severe cutaneous involvement",
"drug": "sulfadiazine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 7-year-old with congenital toxoplasmosis who took pyrimethamine and sulfadiazine for reactivated chorioretinitis developed fever, severe cutaneous involvement, swelling, abdominal pain and transaminitis, persisting weeks after withholding medicines.",
"role": "user"
},
{
"content": "[{\"ade\": \"transaminitis\", \"drug\": \"sulfadiazine\"}, {\"ade\": \"fever\", \"drug\": \"pyrimethamine\"}, {\"ade\": \"fever\", \"drug\": \"sulfadiazine\"}, {\"ade\": \"swelling\", \"drug\": \"sulfadiazine\"}, {\"ade\": \"abdominal pain\", \"drug\": \"pyrimethamine\"}, {\"ade\": \"transaminitis\", \"drug\": \"pyrimethamine\"}, {\"ade\": \"abdominal pain\", \"drug\": \"sulfadiazine\"}, {\"ade\": \"swelling\", \"drug\": \"pyrimethamine\"}, {\"ade\": \"severe cutaneous involvement\", \"drug\": \"pyrimethamine\"}, {\"ade\": \"severe cutaneous involvement\", \"drug\": \"sulfadiazine\"}]",
"role": "assistant"
}
] |
Hepatotoxicity related to itraconazole: report of three cases.
|
[
{
"ade": "Hepatotoxicity",
"drug": "itraconazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Hepatotoxicity related to itraconazole: report of three cases.",
"role": "user"
},
{
"content": "[{\"ade\": \"Hepatotoxicity\", \"drug\": \"itraconazole\"}]",
"role": "assistant"
}
] |
CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.
|
[
{
"ade": "Anterior ischemic optic neuropathy",
"drug": "interferon alfa"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSION: Anterior ischemic optic neuropathy may complicate treatment with interferon alfa.",
"role": "user"
},
{
"content": "[{\"ade\": \"Anterior ischemic optic neuropathy\", \"drug\": \"interferon alfa\"}]",
"role": "assistant"
}
] |
Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.
|
[
{
"ade": "Relapse in the external auditory canal of acute promyelocytic leukemia",
"drug": "all-trans retinoic acid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Relapse in the external auditory canal of acute promyelocytic leukemia after treatment with all-trans retinoic acid.",
"role": "user"
},
{
"content": "[{\"ade\": \"Relapse in the external auditory canal of acute promyelocytic leukemia\", \"drug\": \"all-trans retinoic acid\"}]",
"role": "assistant"
}
] |
Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.
|
[
{
"ade": "Thrombo-embolic complication",
"drug": "streptokinase"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Thrombo-embolic complication after streptokinase therapy of pulmonary emboli.",
"role": "user"
},
{
"content": "[{\"ade\": \"Thrombo-embolic complication\", \"drug\": \"streptokinase\"}]",
"role": "assistant"
}
] |
Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.
|
[
{
"ade": "Gestational diabetes",
"drug": "norethisterone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Gestational diabetes was no less severe (degree of hyperglycaemia, need for insulin therapy) when associated with norethisterone.",
"role": "user"
},
{
"content": "[{\"ade\": \"Gestational diabetes\", \"drug\": \"norethisterone\"}]",
"role": "assistant"
}
] |
This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.
|
[
{
"ade": "encephalopathy syndrome",
"drug": "BH-AC"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This case suggests that BH-AC, a derivative of cytosine arabinoside (1-beta-D-arabinofuranosylcytosine) could be a cause of reversible encephalopathy syndrome.",
"role": "user"
},
{
"content": "[{\"ade\": \"encephalopathy syndrome\", \"drug\": \"BH-AC\"}]",
"role": "assistant"
}
] |
Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.
|
[
{
"ade": "incessant supraventricular tachycardia",
"drug": "Procainamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.",
"role": "user"
},
{
"content": "[{\"ade\": \"incessant supraventricular tachycardia\", \"drug\": \"Procainamide\"}]",
"role": "assistant"
}
] |
We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.
|
[
{
"ade": "Raynaud phenomenon",
"drug": "dextroamphetamine"
},
{
"ade": "Raynaud phenomenon",
"drug": "methylphenidate"
},
{
"ade": "acral cyanosis",
"drug": "methylphenidate"
},
{
"ade": "acral cyanosis",
"drug": "dextroamphetamine"
},
{
"ade": "livedo reticularis",
"drug": "methylphenidate"
},
{
"ade": "livedo reticularis",
"drug": "dextroamphetamine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.",
"role": "user"
},
{
"content": "[{\"ade\": \"Raynaud phenomenon\", \"drug\": \"dextroamphetamine\"}, {\"ade\": \"Raynaud phenomenon\", \"drug\": \"methylphenidate\"}, {\"ade\": \"acral cyanosis\", \"drug\": \"methylphenidate\"}, {\"ade\": \"acral cyanosis\", \"drug\": \"dextroamphetamine\"}, {\"ade\": \"livedo reticularis\", \"drug\": \"methylphenidate\"}, {\"ade\": \"livedo reticularis\", \"drug\": \"dextroamphetamine\"}]",
"role": "assistant"
}
] |
Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.
|
[
{
"ade": "Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with propylthiouracil therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis\", \"drug\": \"propylthiouracil\"}]",
"role": "assistant"
}
] |
However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.
|
[
{
"ade": "diabetes mellitus",
"drug": "norethisterone"
},
{
"ade": "impaired glucose tolerance",
"drug": "norethisterone"
},
{
"ade": "gestational diabetes",
"drug": "norethisterone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.",
"role": "user"
},
{
"content": "[{\"ade\": \"diabetes mellitus\", \"drug\": \"norethisterone\"}, {\"ade\": \"impaired glucose tolerance\", \"drug\": \"norethisterone\"}, {\"ade\": \"gestational diabetes\", \"drug\": \"norethisterone\"}]",
"role": "assistant"
}
] |
Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.
|
[
{
"ade": "pulmonary toxicity",
"drug": "docetaxel"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.",
"role": "user"
},
{
"content": "[{\"ade\": \"pulmonary toxicity\", \"drug\": \"docetaxel\"}]",
"role": "assistant"
}
] |
This is the second report of lactic acidosis in a patient on stavudine and lamivudine.
|
[
{
"ade": "lactic acidosis",
"drug": "stavudine"
},
{
"ade": "lactic acidosis",
"drug": "lamivudine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This is the second report of lactic acidosis in a patient on stavudine and lamivudine.",
"role": "user"
},
{
"content": "[{\"ade\": \"lactic acidosis\", \"drug\": \"stavudine\"}, {\"ade\": \"lactic acidosis\", \"drug\": \"lamivudine\"}]",
"role": "assistant"
}
] |
Here, we report a case of angio-oedema associated with VRC therapy.
|
[
{
"ade": "angio-oedema",
"drug": "VRC"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Here, we report a case of angio-oedema associated with VRC therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"angio-oedema\", \"drug\": \"VRC\"}]",
"role": "assistant"
}
] |
An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.
|
[
{
"ade": "encephalopathy",
"drug": "aluminum"
},
{
"ade": "cardiomyopathy",
"drug": "aluminum"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: An encephalopathy and cardiomyopathy developed in a seventeen-year-old girl with chemotherapy-induced renal failure while receiving an intravesical aluminum infusion for hemorrhagic cystitis.",
"role": "user"
},
{
"content": "[{\"ade\": \"encephalopathy\", \"drug\": \"aluminum\"}, {\"ade\": \"cardiomyopathy\", \"drug\": \"aluminum\"}]",
"role": "assistant"
}
] |
We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.
|
[
{
"ade": "asthma",
"drug": "captopril"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe the first case of de novo asthma following treatment with the angiotensin converting enzyme (ACE) inhibitor captopril.",
"role": "user"
},
{
"content": "[{\"ade\": \"asthma\", \"drug\": \"captopril\"}]",
"role": "assistant"
}
] |
We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.
|
[
{
"ade": "cholestatic hepatitis",
"drug": "senna"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of senna-induced cholestatic hepatitis which was not diagnosed at presentation.",
"role": "user"
},
{
"content": "[{\"ade\": \"cholestatic hepatitis\", \"drug\": \"senna\"}]",
"role": "assistant"
}
] |
Serotonin syndrome caused by interaction between citalopram and fentanyl.
|
[
{
"ade": "Serotonin syndrome",
"drug": "citalopram"
},
{
"ade": "Serotonin syndrome",
"drug": "fentanyl"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Serotonin syndrome caused by interaction between citalopram and fentanyl.",
"role": "user"
},
{
"content": "[{\"ade\": \"Serotonin syndrome\", \"drug\": \"citalopram\"}, {\"ade\": \"Serotonin syndrome\", \"drug\": \"fentanyl\"}]",
"role": "assistant"
}
] |
Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.
|
[
{
"ade": "retroperitoneal fibrosis",
"drug": "Methysergide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Methysergide-induced retroperitoneal fibrosis: successful outcome and two new laboratory features.",
"role": "user"
},
{
"content": "[{\"ade\": \"retroperitoneal fibrosis\", \"drug\": \"Methysergide\"}]",
"role": "assistant"
}
] |
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