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Linear IgA bullous dermatosis occurring after carbamazepine.
|
[
{
"ade": "Linear IgA bullous dermatosis",
"drug": "carbamazepine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Linear IgA bullous dermatosis occurring after carbamazepine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Linear IgA bullous dermatosis\", \"drug\": \"carbamazepine\"}]",
"role": "assistant"
}
] |
Despite a hematologic response in all 3 patients, none of them achieved cytogenetic remission, and all progressed to blast crisis at 7 to 10 months of imatinib therapy.
|
[
{
"ade": "blast crisis",
"drug": "imatinib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Despite a hematologic response in all 3 patients, none of them achieved cytogenetic remission, and all progressed to blast crisis at 7 to 10 months of imatinib therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"blast crisis\", \"drug\": \"imatinib\"}]",
"role": "assistant"
}
] |
A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.
|
[
{
"ade": "periodic alternating nystagmus",
"drug": "phenytoin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A patient with alcoholic cerebellar degeneration had periodic alternating nystagmus during a period of phenytoin intoxication.",
"role": "user"
},
{
"content": "[{\"ade\": \"periodic alternating nystagmus\", \"drug\": \"phenytoin\"}]",
"role": "assistant"
}
] |
Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.
|
[
{
"ade": "positive autoantibodies",
"drug": "sulfasalazine"
},
{
"ade": "Pneumonitis",
"drug": "sulfasalazine"
},
{
"ade": "cardiac tamponade",
"drug": "sulfasalazine"
},
{
"ade": "bilateral pleural effusions",
"drug": "sulfasalazine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Pneumonitis, bilateral pleural effusions, echocardiographic evidence of cardiac tamponade, and positive autoantibodies developed in a 43-year-old man, who was receiving long-term sulfasalazine therapy for chronic ulcerative colitis.",
"role": "user"
},
{
"content": "[{\"ade\": \"positive autoantibodies\", \"drug\": \"sulfasalazine\"}, {\"ade\": \"Pneumonitis\", \"drug\": \"sulfasalazine\"}, {\"ade\": \"cardiac tamponade\", \"drug\": \"sulfasalazine\"}, {\"ade\": \"bilateral pleural effusions\", \"drug\": \"sulfasalazine\"}]",
"role": "assistant"
}
] |
Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.
|
[
{
"ade": "acute pancreatitis",
"drug": "propofol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute pancreatitis\", \"drug\": \"propofol\"}]",
"role": "assistant"
}
] |
Use of the Naranjo probability scale indicated a highly probable relationship between the observed cardiac toxicity and amphotericin B deoxycholate therapy in this patient.
|
[
{
"ade": "cardiac toxicity",
"drug": "amphotericin B deoxycholate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Use of the Naranjo probability scale indicated a highly probable relationship between the observed cardiac toxicity and amphotericin B deoxycholate therapy in this patient.",
"role": "user"
},
{
"content": "[{\"ade\": \"cardiac toxicity\", \"drug\": \"amphotericin B deoxycholate\"}]",
"role": "assistant"
}
] |
Dermatitis to captopril.
|
[
{
"ade": "Dermatitis",
"drug": "captopril"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Dermatitis to captopril.",
"role": "user"
},
{
"content": "[{\"ade\": \"Dermatitis\", \"drug\": \"captopril\"}]",
"role": "assistant"
}
] |
Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.
|
[
{
"ade": "methemoglobinemia",
"drug": "Benzocaine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.",
"role": "user"
},
{
"content": "[{\"ade\": \"methemoglobinemia\", \"drug\": \"Benzocaine\"}]",
"role": "assistant"
}
] |
Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.
|
[
{
"ade": "cholesterol crystal embolization",
"drug": "t-PA"
},
{
"ade": "atheroembolic acute renal failure",
"drug": "t-PA"
},
{
"ade": "extrarenal manifestations",
"drug": "t-PA"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although there is one case report of cholesterol crystal embolization following t-PA therapy with only extrarenal manifestations (N Engl J Med 321:1270, 1989), this is the first reported case of atheroembolic acute renal failure following t-PA therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"cholesterol crystal embolization\", \"drug\": \"t-PA\"}, {\"ade\": \"atheroembolic acute renal failure\", \"drug\": \"t-PA\"}, {\"ade\": \"extrarenal manifestations\", \"drug\": \"t-PA\"}]",
"role": "assistant"
}
] |
Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.
|
[
{
"ade": "polymorphic ventricular tachycardia",
"drug": "Levofloxacin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.",
"role": "user"
},
{
"content": "[{\"ade\": \"polymorphic ventricular tachycardia\", \"drug\": \"Levofloxacin\"}]",
"role": "assistant"
}
] |
We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.
|
[
{
"ade": "fatal fulminant hepatitis",
"drug": "CPA"
},
{
"ade": "severe hepatocellular damage",
"drug": "CPA"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report 3 patients with severe hepatocellular damage due to CPA therapy, 2 with fatal fulminant hepatitis.",
"role": "user"
},
{
"content": "[{\"ade\": \"fatal fulminant hepatitis\", \"drug\": \"CPA\"}, {\"ade\": \"severe hepatocellular damage\", \"drug\": \"CPA\"}]",
"role": "assistant"
}
] |
Nephrotic syndrome associated with lithium therapy.
|
[
{
"ade": "Nephrotic syndrome",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Nephrotic syndrome associated with lithium therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Nephrotic syndrome\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.
|
[
{
"ade": "Creutzfeldt-Jakob like syndrome",
"drug": "lithium carbonate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"Creutzfeldt-Jakob like syndrome\", \"drug\": \"lithium carbonate\"}]",
"role": "assistant"
}
] |
Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.
|
[
{
"ade": "Acute renal failure",
"drug": "iodine"
},
{
"ade": "Acute renal failure",
"drug": "povidone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute renal failure in a patient treated by continuous povidone-iodine mediastinal irrigation.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute renal failure\", \"drug\": \"iodine\"}, {\"ade\": \"Acute renal failure\", \"drug\": \"povidone\"}]",
"role": "assistant"
}
] |
CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.
|
[
{
"ade": "cardiac arrhythmias",
"drug": "HCQ"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSION: The chronic use of HCQ for rheumatic diseases, or as an anti-malarial drug, should be balanced against the risk of developing potentially lethal cardiac arrhythmias.",
"role": "user"
},
{
"content": "[{\"ade\": \"cardiac arrhythmias\", \"drug\": \"HCQ\"}]",
"role": "assistant"
}
] |
We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.
|
[
{
"ade": "interstitial pneumonitis",
"drug": "bicalutamide"
},
{
"ade": "interstitial pneumonitis",
"drug": "leuprorelin acetate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of interstitial pneumonitis induced by bicalutamide and/or leuprorelin acetate given as therapy for prostate cancer, in which the pneumonitis was successfully managed by steroid treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"interstitial pneumonitis\", \"drug\": \"bicalutamide\"}, {\"ade\": \"interstitial pneumonitis\", \"drug\": \"leuprorelin acetate\"}]",
"role": "assistant"
}
] |
Intranasal desmopressin-induced hyponatremia.
|
[
{
"ade": "hyponatremia",
"drug": "desmopressin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Intranasal desmopressin-induced hyponatremia.",
"role": "user"
},
{
"content": "[{\"ade\": \"hyponatremia\", \"drug\": \"desmopressin\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.
|
[
{
"ade": "toxic epidermal necrolysis",
"drug": "ofloxacin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: There is very little published information regarding ofloxacin-induced toxic epidermal necrolysis.",
"role": "user"
},
{
"content": "[{\"ade\": \"toxic epidermal necrolysis\", \"drug\": \"ofloxacin\"}]",
"role": "assistant"
}
] |
Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.
|
[
{
"ade": "abnormal liver function tests",
"drug": "cyproterone acetate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Monitoring of liver function tests should be mandatory in patients receiving high doses of cyproterone acetate; the drug should be withdrawn immediately if abnormal liver function tests are found.",
"role": "user"
},
{
"content": "[{\"ade\": \"abnormal liver function tests\", \"drug\": \"cyproterone acetate\"}]",
"role": "assistant"
}
] |
We report the first case of IHA associated with cefuroxime administration.
|
[
{
"ade": "IHA",
"drug": "cefuroxime"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report the first case of IHA associated with cefuroxime administration.",
"role": "user"
},
{
"content": "[{\"ade\": \"IHA\", \"drug\": \"cefuroxime\"}]",
"role": "assistant"
}
] |
The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.
|
[
{
"ade": "cholestasis",
"drug": "thiabendazole"
},
{
"ade": "sicca complex",
"drug": "thiabendazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The literature on thiabendazole-induced cholestasis and its association with sicca complex is reviewed.",
"role": "user"
},
{
"content": "[{\"ade\": \"cholestasis\", \"drug\": \"thiabendazole\"}, {\"ade\": \"sicca complex\", \"drug\": \"thiabendazole\"}]",
"role": "assistant"
}
] |
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.
|
[
{
"ade": "multiple myeloma",
"drug": "diphenylhydantoin"
},
{
"ade": "Monoclonal gammopathy",
"drug": "diphenylhydantoin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"multiple myeloma\", \"drug\": \"diphenylhydantoin\"}, {\"ade\": \"Monoclonal gammopathy\", \"drug\": \"diphenylhydantoin\"}]",
"role": "assistant"
}
] |
Isoniazid and ethambutol as a cause of optic neuropathy.
|
[
{
"ade": "optic neuropathy",
"drug": "Isoniazid"
},
{
"ade": "optic neuropathy",
"drug": "ethambutol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Isoniazid and ethambutol as a cause of optic neuropathy.",
"role": "user"
},
{
"content": "[{\"ade\": \"optic neuropathy\", \"drug\": \"Isoniazid\"}, {\"ade\": \"optic neuropathy\", \"drug\": \"ethambutol\"}]",
"role": "assistant"
}
] |
Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.
|
[
{
"ade": "acute coronary ischemia",
"drug": "cis-diamine-dichloroplatinum II"
},
{
"ade": "infarction",
"drug": "cisplatin"
},
{
"ade": "infarction",
"drug": "cis-diamine-dichloroplatinum II"
},
{
"ade": "acute coronary ischemia",
"drug": "cisplatin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute coronary ischemia\", \"drug\": \"cis-diamine-dichloroplatinum II\"}, {\"ade\": \"infarction\", \"drug\": \"cisplatin\"}, {\"ade\": \"infarction\", \"drug\": \"cis-diamine-dichloroplatinum II\"}, {\"ade\": \"acute coronary ischemia\", \"drug\": \"cisplatin\"}]",
"role": "assistant"
}
] |
In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.
|
[
{
"ade": "CIPS",
"drug": "cyclosporine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.",
"role": "user"
},
{
"content": "[{\"ade\": \"CIPS\", \"drug\": \"cyclosporine\"}]",
"role": "assistant"
}
] |
We conclude peripheral neuropathy with 5-FU is rare.
|
[
{
"ade": "peripheral neuropathy",
"drug": "5-FU"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We conclude peripheral neuropathy with 5-FU is rare.",
"role": "user"
},
{
"content": "[{\"ade\": \"peripheral neuropathy\", \"drug\": \"5-FU\"}]",
"role": "assistant"
}
] |
Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.
|
[
{
"ade": "MPGN",
"drug": "Interferon-alpha"
},
{
"ade": "MPGN",
"drug": "IFN-alpha"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN.",
"role": "user"
},
{
"content": "[{\"ade\": \"MPGN\", \"drug\": \"Interferon-alpha\"}, {\"ade\": \"MPGN\", \"drug\": \"IFN-alpha\"}]",
"role": "assistant"
}
] |
Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.
|
[
{
"ade": "coagulopathy",
"drug": "cephalosporin"
},
{
"ade": "coagulopathy",
"drug": "moxalactam"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Nine azotemic patients who developed a coagulopathy associated with the use of either cephalosporin or moxalactam antibiotics are reported.",
"role": "user"
},
{
"content": "[{\"ade\": \"coagulopathy\", \"drug\": \"cephalosporin\"}, {\"ade\": \"coagulopathy\", \"drug\": \"moxalactam\"}]",
"role": "assistant"
}
] |
CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.
|
[
{
"ade": "ground-glass hepatocytes",
"drug": "cyanamide"
},
{
"ade": "septum-like liver fibrosis",
"drug": "cyanamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.",
"role": "user"
},
{
"content": "[{\"ade\": \"ground-glass hepatocytes\", \"drug\": \"cyanamide\"}, {\"ade\": \"septum-like liver fibrosis\", \"drug\": \"cyanamide\"}]",
"role": "assistant"
}
] |
Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.
|
[
{
"ade": "Anterior lumbosacral radiculopathy",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Anterior lumbosacral radiculopathy after intrathecal methotrexate treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"Anterior lumbosacral radiculopathy\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.
|
[
{
"ade": "agranulocytosis",
"drug": "propylthiouracil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 45-year-old woman with thyrotoxicosis developed agranulocytosis after treatment with propylthiouracil.",
"role": "user"
},
{
"content": "[{\"ade\": \"agranulocytosis\", \"drug\": \"propylthiouracil\"}]",
"role": "assistant"
}
] |
Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.
|
[
{
"ade": "intracranial bleeding",
"drug": "amprenavir"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.",
"role": "user"
},
{
"content": "[{\"ade\": \"intracranial bleeding\", \"drug\": \"amprenavir\"}]",
"role": "assistant"
}
] |
Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.
|
[
{
"ade": "tremor",
"drug": "lithium carbonate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Two patients with bipolar affective disorder and a history of bronchospastic phenomena experienced tremor during lithium carbonate therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"tremor\", \"drug\": \"lithium carbonate\"}]",
"role": "assistant"
}
] |
OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.
|
[
{
"ade": "disfiguring facial edema",
"drug": "ribavirin"
},
{
"ade": "disfiguring facial edema",
"drug": "peginterferon alfa-2a"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: OBSERVATIONS: A 48-year-old woman presented with disfiguring facial edema 10 weeks after she began antiviral therapy with peginterferon alfa-2a and ribavirin for chronic hepatitis C infection.",
"role": "user"
},
{
"content": "[{\"ade\": \"disfiguring facial edema\", \"drug\": \"ribavirin\"}, {\"ade\": \"disfiguring facial edema\", \"drug\": \"peginterferon alfa-2a\"}]",
"role": "assistant"
}
] |
Primary CNS lymphoma regressed on withdrawal of MM.
|
[
{
"ade": "CNS lymphoma",
"drug": "MM"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Primary CNS lymphoma regressed on withdrawal of MM.",
"role": "user"
},
{
"content": "[{\"ade\": \"CNS lymphoma\", \"drug\": \"MM\"}]",
"role": "assistant"
}
] |
A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.
|
[
{
"ade": "delirious",
"drug": "oolong tea"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 36-y-o patient with schizophrenia, who had consumed gradually increasing quantities of oolong tea that eventually reached 15 L each day, became delirious and was admitted to a psychiatric hospital.",
"role": "user"
},
{
"content": "[{\"ade\": \"delirious\", \"drug\": \"oolong tea\"}]",
"role": "assistant"
}
] |
Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.
|
[
{
"ade": "Minimal change nephrotic syndrome",
"drug": "interferon-beta"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Minimal change nephrotic syndrome developing during postoperative interferon-beta therapy for malignant melanoma.",
"role": "user"
},
{
"content": "[{\"ade\": \"Minimal change nephrotic syndrome\", \"drug\": \"interferon-beta\"}]",
"role": "assistant"
}
] |
Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.
|
[
{
"ade": "altered mental status",
"drug": "zonisamide"
},
{
"ade": "visual hallucinations",
"drug": "zonisamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.",
"role": "user"
},
{
"content": "[{\"ade\": \"altered mental status\", \"drug\": \"zonisamide\"}, {\"ade\": \"visual hallucinations\", \"drug\": \"zonisamide\"}]",
"role": "assistant"
}
] |
Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.
|
[
{
"ade": "abnormalities in liver function tests",
"drug": "Cyclosporin"
},
{
"ade": "hypertension",
"drug": "Cyclosporin"
},
{
"ade": "increased blood levels of urea and creatinine",
"drug": "Cyclosporin"
},
{
"ade": "hirsutism",
"drug": "Cyclosporin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cyclosporin side effects included hirsutism, hypertension, increased blood levels of urea and creatinine, and abnormalities in liver function tests.",
"role": "user"
},
{
"content": "[{\"ade\": \"abnormalities in liver function tests\", \"drug\": \"Cyclosporin\"}, {\"ade\": \"hypertension\", \"drug\": \"Cyclosporin\"}, {\"ade\": \"increased blood levels of urea and creatinine\", \"drug\": \"Cyclosporin\"}, {\"ade\": \"hirsutism\", \"drug\": \"Cyclosporin\"}]",
"role": "assistant"
}
] |
The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.
|
[
{
"ade": "nodules",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.",
"role": "user"
},
{
"content": "[{\"ade\": \"nodules\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.
|
[
{
"ade": "severe persistent bronchospasm",
"drug": "tobramycin"
},
{
"ade": "recurrent eosinophilia",
"drug": "tobramycin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CASE PRESENTATION: We report a patient with CF who developed recurrent eosinophilia and severe persistent bronchospasm following repeated administration of preservative-free tobramycin by inhalation, beginning at 16 months of age.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe persistent bronchospasm\", \"drug\": \"tobramycin\"}, {\"ade\": \"recurrent eosinophilia\", \"drug\": \"tobramycin\"}]",
"role": "assistant"
}
] |
Corneal endothelial dysfunction associated with amantadine toxicity.
|
[
{
"ade": "Corneal endothelial dysfunction",
"drug": "amantadine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Corneal endothelial dysfunction associated with amantadine toxicity.",
"role": "user"
},
{
"content": "[{\"ade\": \"Corneal endothelial dysfunction\", \"drug\": \"amantadine\"}]",
"role": "assistant"
}
] |
Eruptive epidermoid cysts resulting from treatment with imiquimod.
|
[
{
"ade": "Eruptive epidermoid cysts",
"drug": "imiquimod"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Eruptive epidermoid cysts resulting from treatment with imiquimod.",
"role": "user"
},
{
"content": "[{\"ade\": \"Eruptive epidermoid cysts\", \"drug\": \"imiquimod\"}]",
"role": "assistant"
}
] |
Bromide intoxication secondary to pyridostigmine bromide therapy.
|
[
{
"ade": "Bromide intoxication",
"drug": "pyridostigmine bromide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Bromide intoxication secondary to pyridostigmine bromide therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Bromide intoxication\", \"drug\": \"pyridostigmine bromide\"}]",
"role": "assistant"
}
] |
There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.
|
[
{
"ade": "CML",
"drug": "hydroxyurea"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.",
"role": "user"
},
{
"content": "[{\"ade\": \"CML\", \"drug\": \"hydroxyurea\"}]",
"role": "assistant"
}
] |
We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.
|
[
{
"ade": "blurred vision",
"drug": "cibenzoline"
},
{
"ade": "cibenzoline intoxication",
"drug": "cibenzoline"
},
{
"ade": "cardiac failure",
"drug": "cibenzoline"
},
{
"ade": "QRS broadening",
"drug": "cibenzoline"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.",
"role": "user"
},
{
"content": "[{\"ade\": \"blurred vision\", \"drug\": \"cibenzoline\"}, {\"ade\": \"cibenzoline intoxication\", \"drug\": \"cibenzoline\"}, {\"ade\": \"cardiac failure\", \"drug\": \"cibenzoline\"}, {\"ade\": \"QRS broadening\", \"drug\": \"cibenzoline\"}]",
"role": "assistant"
}
] |
There is no consensus on the treatment of ticlopidine-induced marrow aplasia.
|
[
{
"ade": "marrow aplasia",
"drug": "ticlopidine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: There is no consensus on the treatment of ticlopidine-induced marrow aplasia.",
"role": "user"
},
{
"content": "[{\"ade\": \"marrow aplasia\", \"drug\": \"ticlopidine\"}]",
"role": "assistant"
}
] |
The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.
|
[
{
"ade": "severe restrictive ventilatory defect",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The changes were progressive regardless of discontinuation of cyclophosphamide and led to severe restrictive ventilatory defect.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe restrictive ventilatory defect\", \"drug\": \"cyclophosphamide\"}]",
"role": "assistant"
}
] |
His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.
|
[
{
"ade": "impaired memory",
"drug": "atenolol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker.",
"role": "user"
},
{
"content": "[{\"ade\": \"impaired memory\", \"drug\": \"atenolol\"}]",
"role": "assistant"
}
] |
RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.
|
[
{
"ade": "falling backward",
"drug": "bupropion"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: RESULTS: Both patients experienced a previously unreported side effect--falling backward--associated with bupropion use.",
"role": "user"
},
{
"content": "[{\"ade\": \"falling backward\", \"drug\": \"bupropion\"}]",
"role": "assistant"
}
] |
It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.
|
[
{
"ade": "nephrotic syndrome",
"drug": "M-CSF"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.",
"role": "user"
},
{
"content": "[{\"ade\": \"nephrotic syndrome\", \"drug\": \"M-CSF\"}]",
"role": "assistant"
}
] |
DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.
|
[
{
"ade": "muscle injury with concomitant elevations of serum CK",
"drug": "Olanzapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: DISCUSSION: Olanzapine, like other atypical antipsychotic drugs, may cause muscle injury with concomitant elevations of serum CK of muscle origin.",
"role": "user"
},
{
"content": "[{\"ade\": \"muscle injury with concomitant elevations of serum CK\", \"drug\": \"Olanzapine\"}]",
"role": "assistant"
}
] |
A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.
|
[
{
"ade": "agranulocytosis",
"drug": "dapsone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient.",
"role": "user"
},
{
"content": "[{\"ade\": \"agranulocytosis\", \"drug\": \"dapsone\"}]",
"role": "assistant"
}
] |
Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment.
|
[
{
"ade": "progression of marrow reticulin fibrosis",
"drug": "imatinib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Our findings suggest that significant progression of marrow reticulin fibrosis during imatinib therapy can be an indicator for a return or progression of CML and, in some patients with CML, imatinib may promote cytogenetic clonal evolution, resulting in a poor response to treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"progression of marrow reticulin fibrosis\", \"drug\": \"imatinib\"}]",
"role": "assistant"
}
] |
A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.
|
[
{
"ade": "oculogyric crisis",
"drug": "metoclopramide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A case of metoclopramide-induced oculogyric crisis in a 16-year-old girl with cystic fibrosis.",
"role": "user"
},
{
"content": "[{\"ade\": \"oculogyric crisis\", \"drug\": \"metoclopramide\"}]",
"role": "assistant"
}
] |
The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.
|
[
{
"ade": "exacerbation of psoriasis",
"drug": "imiquimod"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The exacerbation of psoriasis was accompanied by a massive induction of lesional type I interferon activity, detected by MxA expression after imiquimod therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"exacerbation of psoriasis\", \"drug\": \"imiquimod\"}]",
"role": "assistant"
}
] |
Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.
|
[
{
"ade": "Vision declined",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Vision declined after treatment with methylprednisolone, after which fundus examination became consistent with progressive outer retinal necrosis.",
"role": "user"
},
{
"content": "[{\"ade\": \"Vision declined\", \"drug\": \"methylprednisolone\"}]",
"role": "assistant"
}
] |
Acute renal failure during lisinopril and losartan therapy for proteinuria.
|
[
{
"ade": "Acute renal failure",
"drug": "losartan"
},
{
"ade": "Acute renal failure",
"drug": "lisinopril"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute renal failure during lisinopril and losartan therapy for proteinuria.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute renal failure\", \"drug\": \"losartan\"}, {\"ade\": \"Acute renal failure\", \"drug\": \"lisinopril\"}]",
"role": "assistant"
}
] |
Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.
|
[
{
"ade": "increase in total Hb",
"drug": "HU"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.",
"role": "user"
},
{
"content": "[{\"ade\": \"increase in total Hb\", \"drug\": \"HU\"}]",
"role": "assistant"
}
] |
We report a case of a child with neurodevelopmental delay with chronic constipation and a history of chronic mineral oil ingestion presenting as asymptomatic exogenous lipoid pneumonia (ELP).
|
[
{
"ade": "exogenous lipoid pneumonia",
"drug": "mineral oil"
},
{
"ade": "ELP",
"drug": "mineral oil"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report a case of a child with neurodevelopmental delay with chronic constipation and a history of chronic mineral oil ingestion presenting as asymptomatic exogenous lipoid pneumonia (ELP).",
"role": "user"
},
{
"content": "[{\"ade\": \"exogenous lipoid pneumonia\", \"drug\": \"mineral oil\"}, {\"ade\": \"ELP\", \"drug\": \"mineral oil\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.
|
[
{
"ade": "electrolyte disorders",
"drug": "foscarnet"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: It is probable that foscarnet contributed to the electrolyte disorders and symptomatology in this patient.",
"role": "user"
},
{
"content": "[{\"ade\": \"electrolyte disorders\", \"drug\": \"foscarnet\"}]",
"role": "assistant"
}
] |
This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.
|
[
{
"ade": "hypoxia",
"drug": "indomethacin"
},
{
"ade": "ductal closure",
"drug": "indomethacin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This selective closure of the ductus arteriosus suggests that the affected twin was predisposed to hypoxia and thus was more susceptible to ductal closure in response to indomethacin exposure.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypoxia\", \"drug\": \"indomethacin\"}, {\"ade\": \"ductal closure\", \"drug\": \"indomethacin\"}]",
"role": "assistant"
}
] |
Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.
|
[
{
"ade": "reversible granulocytopenia",
"drug": "procainamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Sustained-release procainamide-induced reversible granulocytopenia after myocardial infarction.",
"role": "user"
},
{
"content": "[{\"ade\": \"reversible granulocytopenia\", \"drug\": \"procainamide\"}]",
"role": "assistant"
}
] |
Acute renal failure should be recognized as a potential complication of suramin treatment.
|
[
{
"ade": "renal failure",
"drug": "suramin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute renal failure should be recognized as a potential complication of suramin treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"renal failure\", \"drug\": \"suramin\"}]",
"role": "assistant"
}
] |
Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.
|
[
{
"ade": "flare-up",
"drug": "goserelin acetate"
},
{
"ade": "worsening pleuritis carcinomatosa",
"drug": "goserelin acetate"
},
{
"ade": "severe dyspnea",
"drug": "goserelin acetate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.",
"role": "user"
},
{
"content": "[{\"ade\": \"flare-up\", \"drug\": \"goserelin acetate\"}, {\"ade\": \"worsening pleuritis carcinomatosa\", \"drug\": \"goserelin acetate\"}, {\"ade\": \"severe dyspnea\", \"drug\": \"goserelin acetate\"}]",
"role": "assistant"
}
] |
Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.
|
[
{
"ade": "Acute erythroid leukemia",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.",
"role": "user"
},
{
"content": "[{\"ade\": \"Acute erythroid leukemia\", \"drug\": \"cyclophosphamide\"}]",
"role": "assistant"
}
] |
Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.
|
[
{
"ade": "Fatal pulmonary fibrosis",
"drug": "BCNU"
},
{
"ade": "Fatal pulmonary fibrosis",
"drug": "1,3-bis(2-chloroethyl)-1-nitrosourea"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Fatal pulmonary fibrosis following 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Fatal pulmonary fibrosis\", \"drug\": \"BCNU\"}, {\"ade\": \"Fatal pulmonary fibrosis\", \"drug\": \"1,3-bis(2-chloroethyl)-1-nitrosourea\"}]",
"role": "assistant"
}
] |
Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.
|
[
{
"ade": "psychiatric symptoms",
"drug": "lidocaine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Awareness of this route of intoxication might be important in patients in whom neurologic or psychiatric symptoms develop while large amounts of lidocaine cream are being used.",
"role": "user"
},
{
"content": "[{\"ade\": \"psychiatric symptoms\", \"drug\": \"lidocaine\"}]",
"role": "assistant"
}
] |
Multiple seizures after bupropion overdose in a small child.
|
[
{
"ade": "Multiple seizures",
"drug": "bupropion"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Multiple seizures after bupropion overdose in a small child.",
"role": "user"
},
{
"content": "[{\"ade\": \"Multiple seizures\", \"drug\": \"bupropion\"}]",
"role": "assistant"
}
] |
Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.
|
[
{
"ade": "hyperglycaemic coma",
"drug": "Olanzapine"
},
{
"ade": "neuroleptic malignant syndrome",
"drug": "Olanzapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Olanzapine-induced hyperglycaemic coma and neuroleptic malignant syndrome: case report and review of literature.",
"role": "user"
},
{
"content": "[{\"ade\": \"hyperglycaemic coma\", \"drug\": \"Olanzapine\"}, {\"ade\": \"neuroleptic malignant syndrome\", \"drug\": \"Olanzapine\"}]",
"role": "assistant"
}
] |
Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.
|
[
{
"ade": "torsades de pointe",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although a lot of amiodarone-induced torsades de pointe have been published, a review of all these cases and the underlying risk-factors has never been made.",
"role": "user"
},
{
"content": "[{\"ade\": \"torsades de pointe\", \"drug\": \"amiodarone\"}]",
"role": "assistant"
}
] |
Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.
|
[
{
"ade": "thrombocyte count started to increase",
"drug": "piperacillin"
},
{
"ade": "thrombocyte count started to increase",
"drug": "ciprofloxacin"
},
{
"ade": "thrombocyte count started to increase",
"drug": "tazobactam"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.",
"role": "user"
},
{
"content": "[{\"ade\": \"thrombocyte count started to increase\", \"drug\": \"piperacillin\"}, {\"ade\": \"thrombocyte count started to increase\", \"drug\": \"ciprofloxacin\"}, {\"ade\": \"thrombocyte count started to increase\", \"drug\": \"tazobactam\"}]",
"role": "assistant"
}
] |
Priapism associated with olanzapine.
|
[
{
"ade": "Priapism",
"drug": "olanzapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Priapism associated with olanzapine.",
"role": "user"
},
{
"content": "[{\"ade\": \"Priapism\", \"drug\": \"olanzapine\"}]",
"role": "assistant"
}
] |
These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.
|
[
{
"ade": "arrhythmias",
"drug": "lopinavir"
},
{
"ade": "arrhythmias",
"drug": "ritonavir"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: These two cases highlight the importance of considering lopinavir/ritonavir induced arrhythmias when dealing with HIV-positive individuals.",
"role": "user"
},
{
"content": "[{\"ade\": \"arrhythmias\", \"drug\": \"lopinavir\"}, {\"ade\": \"arrhythmias\", \"drug\": \"ritonavir\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.
|
[
{
"ade": "angle-closure glaucoma",
"drug": "Topiramate"
},
{
"ade": "anterior chamber shallowing",
"drug": "Topiramate"
},
{
"ade": "displacement of the lens-iris diaphragm",
"drug": "Topiramate"
},
{
"ade": "acute myopia",
"drug": "Topiramate"
},
{
"ade": "ciliochoroidal effusion",
"drug": "Topiramate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma.",
"role": "user"
},
{
"content": "[{\"ade\": \"angle-closure glaucoma\", \"drug\": \"Topiramate\"}, {\"ade\": \"anterior chamber shallowing\", \"drug\": \"Topiramate\"}, {\"ade\": \"displacement of the lens-iris diaphragm\", \"drug\": \"Topiramate\"}, {\"ade\": \"acute myopia\", \"drug\": \"Topiramate\"}, {\"ade\": \"ciliochoroidal effusion\", \"drug\": \"Topiramate\"}]",
"role": "assistant"
}
] |
Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.
|
[
{
"ade": "cardiomyopathy",
"drug": "Adriamycin"
},
{
"ade": "nephrotoxicity",
"drug": "cis-platinum"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.",
"role": "user"
},
{
"content": "[{\"ade\": \"cardiomyopathy\", \"drug\": \"Adriamycin\"}, {\"ade\": \"nephrotoxicity\", \"drug\": \"cis-platinum\"}]",
"role": "assistant"
}
] |
It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.
|
[
{
"ade": "VBDS",
"drug": "ciprofloxacin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.",
"role": "user"
},
{
"content": "[{\"ade\": \"VBDS\", \"drug\": \"ciprofloxacin\"}]",
"role": "assistant"
}
] |
A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).
|
[
{
"ade": "AVT",
"drug": "quinidine"
},
{
"ade": "AVT",
"drug": "disopyramide"
},
{
"ade": "torsade de pointes",
"drug": "quinidine"
},
{
"ade": "atypical ventricular tachycardia",
"drug": "quinidine"
},
{
"ade": "AVT",
"drug": "amiodarone"
},
{
"ade": "torsade de pointes",
"drug": "amiodarone"
},
{
"ade": "atypical ventricular tachycardia",
"drug": "disopyramide"
},
{
"ade": "atypical ventricular tachycardia",
"drug": "amiodarone"
},
{
"ade": "torsade de pointes",
"drug": "disopyramide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).",
"role": "user"
},
{
"content": "[{\"ade\": \"AVT\", \"drug\": \"quinidine\"}, {\"ade\": \"AVT\", \"drug\": \"disopyramide\"}, {\"ade\": \"torsade de pointes\", \"drug\": \"quinidine\"}, {\"ade\": \"atypical ventricular tachycardia\", \"drug\": \"quinidine\"}, {\"ade\": \"AVT\", \"drug\": \"amiodarone\"}, {\"ade\": \"torsade de pointes\", \"drug\": \"amiodarone\"}, {\"ade\": \"atypical ventricular tachycardia\", \"drug\": \"disopyramide\"}, {\"ade\": \"atypical ventricular tachycardia\", \"drug\": \"amiodarone\"}, {\"ade\": \"torsade de pointes\", \"drug\": \"disopyramide\"}]",
"role": "assistant"
}
] |
Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.
|
[
{
"ade": "neuroleptic malignant syndrome",
"drug": "metoclopramide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Fulminant metoclopramide induced neuroleptic malignant syndrome rapidly responsive to intravenous dantrolene.",
"role": "user"
},
{
"content": "[{\"ade\": \"neuroleptic malignant syndrome\", \"drug\": \"metoclopramide\"}]",
"role": "assistant"
}
] |
Splenic hemorrhage: a complication of tissue plasminogen activator treatment.
|
[
{
"ade": "Splenic hemorrhage",
"drug": "tissue plasminogen activator"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Splenic hemorrhage: a complication of tissue plasminogen activator treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"Splenic hemorrhage\", \"drug\": \"tissue plasminogen activator\"}]",
"role": "assistant"
}
] |
A case of mania associated with fluoxetine.
|
[
{
"ade": "mania",
"drug": "fluoxetine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A case of mania associated with fluoxetine.",
"role": "user"
},
{
"content": "[{\"ade\": \"mania\", \"drug\": \"fluoxetine\"}]",
"role": "assistant"
}
] |
Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.
|
[
{
"ade": "Multifocal inflammatory leukoencephalopathy",
"drug": "levamisole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Multifocal inflammatory leukoencephalopathy\", \"drug\": \"levamisole\"}]",
"role": "assistant"
}
] |
We present a case of sotalol-induced bradycardia reversed by glucagon.
|
[
{
"ade": "bradycardia",
"drug": "sotalol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present a case of sotalol-induced bradycardia reversed by glucagon.",
"role": "user"
},
{
"content": "[{\"ade\": \"bradycardia\", \"drug\": \"sotalol\"}]",
"role": "assistant"
}
] |
Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.
|
[
{
"ade": "Scleroderma-like reaction",
"drug": "uracil-tegafur"
},
{
"ade": "Scleroderma-like reaction",
"drug": "UFT"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.",
"role": "user"
},
{
"content": "[{\"ade\": \"Scleroderma-like reaction\", \"drug\": \"uracil-tegafur\"}, {\"ade\": \"Scleroderma-like reaction\", \"drug\": \"UFT\"}]",
"role": "assistant"
}
] |
Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.
|
[
{
"ade": "Cerebral demyelinating disease",
"drug": "levamisole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cerebral demyelinating disease developed in a patient during adjuvant therapy with levamisole for malignant melanoma.",
"role": "user"
},
{
"content": "[{\"ade\": \"Cerebral demyelinating disease\", \"drug\": \"levamisole\"}]",
"role": "assistant"
}
] |
It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.
|
[
{
"ade": "hypertension",
"drug": "lead"
},
{
"ade": "lead-induced hypertension",
"drug": "lead"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: It also highlights a current major etiologic question, that is, whether and to what degree lead exposure contributes to the development of hypertension, and raises the issue of whether lead-induced hypertension constitutes a subset of hypertension that is especially amenable to therapy with dietary calcium.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypertension\", \"drug\": \"lead\"}, {\"ade\": \"lead-induced hypertension\", \"drug\": \"lead\"}]",
"role": "assistant"
}
] |
Cephalosporins are most likely associated with Vitamin K deficiency.
|
[
{
"ade": "Vitamin K deficiency",
"drug": "Cephalosporins"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cephalosporins are most likely associated with Vitamin K deficiency.",
"role": "user"
},
{
"content": "[{\"ade\": \"Vitamin K deficiency\", \"drug\": \"Cephalosporins\"}]",
"role": "assistant"
}
] |
A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.
|
[
{
"ade": "one patient became unconscious",
"drug": "cotrimoxazole"
},
{
"ade": "hyperkalaemia",
"drug": "cotrimoxazole"
},
{
"ade": "increased urinary N-acetyl glucosaminase",
"drug": "cotrimoxazole"
},
{
"ade": "elevation of serum creatinine and blood urea",
"drug": "cotrimoxazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A high dose of cotrimoxazole induced hyperkalaemia with the elevation of serum creatinine and blood urea, and increased urinary N-acetyl glucosaminase after several days of the drug administration in these patients; one patient became unconscious.",
"role": "user"
},
{
"content": "[{\"ade\": \"one patient became unconscious\", \"drug\": \"cotrimoxazole\"}, {\"ade\": \"hyperkalaemia\", \"drug\": \"cotrimoxazole\"}, {\"ade\": \"increased urinary N-acetyl glucosaminase\", \"drug\": \"cotrimoxazole\"}, {\"ade\": \"elevation of serum creatinine and blood urea\", \"drug\": \"cotrimoxazole\"}]",
"role": "assistant"
}
] |
Massive plasmocytosis due to methimazole-induced bone marrow toxicity.
|
[
{
"ade": "Massive plasmocytosis",
"drug": "methimazole"
},
{
"ade": "bone marrow toxicity",
"drug": "methimazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Massive plasmocytosis due to methimazole-induced bone marrow toxicity.",
"role": "user"
},
{
"content": "[{\"ade\": \"Massive plasmocytosis\", \"drug\": \"methimazole\"}, {\"ade\": \"bone marrow toxicity\", \"drug\": \"methimazole\"}]",
"role": "assistant"
}
] |
However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.
|
[
{
"ade": "vitreous hemorrhage",
"drug": "tPA"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: However, repeated intracameral tPA injections may cause unwanted complications such as vitreous hemorrhage.",
"role": "user"
},
{
"content": "[{\"ade\": \"vitreous hemorrhage\", \"drug\": \"tPA\"}]",
"role": "assistant"
}
] |
An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.
|
[
{
"ade": "severe enteropathy",
"drug": "clofazimine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe enteropathy\", \"drug\": \"clofazimine\"}]",
"role": "assistant"
}
] |
Edema associated with ibuprofen therapy.
|
[
{
"ade": "Edema",
"drug": "ibuprofen"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Edema associated with ibuprofen therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Edema\", \"drug\": \"ibuprofen\"}]",
"role": "assistant"
}
] |
Life-threatening hyponatremia caused by vinblastine.
|
[
{
"ade": "hyponatremia",
"drug": "vinblastine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Life-threatening hyponatremia caused by vinblastine.",
"role": "user"
},
{
"content": "[{\"ade\": \"hyponatremia\", \"drug\": \"vinblastine\"}]",
"role": "assistant"
}
] |
However, 1 eye had vitreous hemorrhage after repeated injections of tPA.
|
[
{
"ade": "vitreous hemorrhage",
"drug": "tPA"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: However, 1 eye had vitreous hemorrhage after repeated injections of tPA.",
"role": "user"
},
{
"content": "[{\"ade\": \"vitreous hemorrhage\", \"drug\": \"tPA\"}]",
"role": "assistant"
}
] |
Histopathology of the thyroid in amiodarone-induced hypothyroidism.
|
[
{
"ade": "hypothyroidism",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Histopathology of the thyroid in amiodarone-induced hypothyroidism.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypothyroidism\", \"drug\": \"amiodarone\"}]",
"role": "assistant"
}
] |
Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.
|
[
{
"ade": "Myoglobinuria",
"drug": "vasopressin"
},
{
"ade": "acute renal failure",
"drug": "vasopressin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Myoglobinuria and acute renal failure were observed in two patients with vasopressin-treated gastrointestinal hemorrhage.",
"role": "user"
},
{
"content": "[{\"ade\": \"Myoglobinuria\", \"drug\": \"vasopressin\"}, {\"ade\": \"acute renal failure\", \"drug\": \"vasopressin\"}]",
"role": "assistant"
}
] |
The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.
|
[
{
"ade": "systemic iron toxicity",
"drug": "iron sucrose"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity.",
"role": "user"
},
{
"content": "[{\"ade\": \"systemic iron toxicity\", \"drug\": \"iron sucrose\"}]",
"role": "assistant"
}
] |
While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.
|
[
{
"ade": "positive U waves",
"drug": "phenylephrine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: While on a maximal dose of phenylephrine she developed prominent positive U waves, which disappeared with the cessation of the drug.",
"role": "user"
},
{
"content": "[{\"ade\": \"positive U waves\", \"drug\": \"phenylephrine\"}]",
"role": "assistant"
}
] |
We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.
|
[
{
"ade": "hepatitis",
"drug": "pegvisomant"
},
{
"ade": "hepatitis",
"drug": "octreotide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report on a patient with acromegaly who developed severe drug-induced hepatitis during combined treatment with the long-acting somatostatin-analog octreotide and the GH receptor antagonist pegvisomant.",
"role": "user"
},
{
"content": "[{\"ade\": \"hepatitis\", \"drug\": \"pegvisomant\"}, {\"ade\": \"hepatitis\", \"drug\": \"octreotide\"}]",
"role": "assistant"
}
] |
Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.
|
[
{
"ade": "Musculoskeletal complaints",
"drug": "cyclophosphamide"
},
{
"ade": "Musculoskeletal complaints",
"drug": "ifosfamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.",
"role": "user"
},
{
"content": "[{\"ade\": \"Musculoskeletal complaints\", \"drug\": \"cyclophosphamide\"}, {\"ade\": \"Musculoskeletal complaints\", \"drug\": \"ifosfamide\"}]",
"role": "assistant"
}
] |
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