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Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.
|
[
{
"ade": "dyskinesia",
"drug": "amoxapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Occurrence of withdrawal dyskinesia indicates that the neuroleptic effects of amoxapine may be clinically significant.",
"role": "user"
},
{
"content": "[{\"ade\": \"dyskinesia\", \"drug\": \"amoxapine\"}]",
"role": "assistant"
}
] |
Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.
|
[
{
"ade": "Myoclonus",
"drug": "levodopa"
},
{
"ade": "seizures",
"drug": "levodopa"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.",
"role": "user"
},
{
"content": "[{\"ade\": \"Myoclonus\", \"drug\": \"levodopa\"}, {\"ade\": \"seizures\", \"drug\": \"levodopa\"}]",
"role": "assistant"
}
] |
Osteomyelitis occurring during infliximab treatment of severe psoriasis.
|
[
{
"ade": "Osteomyelitis",
"drug": "infliximab"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Osteomyelitis occurring during infliximab treatment of severe psoriasis.",
"role": "user"
},
{
"content": "[{\"ade\": \"Osteomyelitis\", \"drug\": \"infliximab\"}]",
"role": "assistant"
}
] |
The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.
|
[
{
"ade": "nausea",
"drug": "amifostine"
},
{
"ade": "hypocalcemia",
"drug": "amifostine"
},
{
"ade": "vomiting",
"drug": "amifostine"
},
{
"ade": "allergic reactions",
"drug": "amifostine"
},
{
"ade": "hypotension",
"drug": "amifostine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The most common side effects associated with amifostine are nausea, vomiting, hypotension, hypocalcemia and allergic reactions.",
"role": "user"
},
{
"content": "[{\"ade\": \"nausea\", \"drug\": \"amifostine\"}, {\"ade\": \"hypocalcemia\", \"drug\": \"amifostine\"}, {\"ade\": \"vomiting\", \"drug\": \"amifostine\"}, {\"ade\": \"allergic reactions\", \"drug\": \"amifostine\"}, {\"ade\": \"hypotension\", \"drug\": \"amifostine\"}]",
"role": "assistant"
}
] |
We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).
|
[
{
"ade": "infectious mononucleosis-like syndrome",
"drug": "SASP"
},
{
"ade": "infectious mononucleosis-like syndrome",
"drug": "salazosulfapyridine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report two patients with infectious mononucleosis-like syndrome induced by salazosulfapyridine (SASP).",
"role": "user"
},
{
"content": "[{\"ade\": \"infectious mononucleosis-like syndrome\", \"drug\": \"SASP\"}, {\"ade\": \"infectious mononucleosis-like syndrome\", \"drug\": \"salazosulfapyridine\"}]",
"role": "assistant"
}
] |
The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.
|
[
{
"ade": "field defects",
"drug": "vigabatrin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The field defects and some electrophysiological abnormalities persist when vigabatrin therapy is withdrawn.",
"role": "user"
},
{
"content": "[{\"ade\": \"field defects\", \"drug\": \"vigabatrin\"}]",
"role": "assistant"
}
] |
Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.
|
[
{
"ade": "neurotoxic effects",
"drug": "ofloxacin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.",
"role": "user"
},
{
"content": "[{\"ade\": \"neurotoxic effects\", \"drug\": \"ofloxacin\"}]",
"role": "assistant"
}
] |
A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.
|
[
{
"ade": "IgA deficiency",
"drug": "fenclofenac"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 35-year-old man with seropositive rheumatoid arthritis developed selective IgA deficiency during treatment with fenclofenac.",
"role": "user"
},
{
"content": "[{\"ade\": \"IgA deficiency\", \"drug\": \"fenclofenac\"}]",
"role": "assistant"
}
] |
Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.
|
[
{
"ade": "renal failure",
"drug": "gemcitabine"
},
{
"ade": "Thrombotic microangiopathy",
"drug": "gemcitabine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Thrombotic microangiopathy with renal failure in two patients undergoing gemcitabine chemotherapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"renal failure\", \"drug\": \"gemcitabine\"}, {\"ade\": \"Thrombotic microangiopathy\", \"drug\": \"gemcitabine\"}]",
"role": "assistant"
}
] |
A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.
|
[
{
"ade": "sudden cutaneous reaction",
"drug": "tacrolimus"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.",
"role": "user"
},
{
"content": "[{\"ade\": \"sudden cutaneous reaction\", \"drug\": \"tacrolimus\"}]",
"role": "assistant"
}
] |
Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.
|
[
{
"ade": "Skin rash",
"drug": "phenobarbital"
},
{
"ade": "hepatocellular failure",
"drug": "phenobarbital"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.",
"role": "user"
},
{
"content": "[{\"ade\": \"Skin rash\", \"drug\": \"phenobarbital\"}, {\"ade\": \"hepatocellular failure\", \"drug\": \"phenobarbital\"}]",
"role": "assistant"
}
] |
We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.
|
[
{
"ade": "respiratory failure",
"drug": "nitrofurantoin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.",
"role": "user"
},
{
"content": "[{\"ade\": \"respiratory failure\", \"drug\": \"nitrofurantoin\"}]",
"role": "assistant"
}
] |
We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.
|
[
{
"ade": "intoxication",
"drug": "mirtazapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report the case of intoxication of a 41-year-old female patient suffering from major depression with mirtazapine complicated by severe hypothermia.",
"role": "user"
},
{
"content": "[{\"ade\": \"intoxication\", \"drug\": \"mirtazapine\"}]",
"role": "assistant"
}
] |
Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.
|
[
{
"ade": "methemoglobinemia",
"drug": "Benzocaine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Benzocaine, an ester-type local anesthetic, was believed responsible for apparent methemoglobinemia in a cat.",
"role": "user"
},
{
"content": "[{\"ade\": \"methemoglobinemia\", \"drug\": \"Benzocaine\"}]",
"role": "assistant"
}
] |
Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.
|
[
{
"ade": "aplastic anemia",
"drug": "lenalidomide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.",
"role": "user"
},
{
"content": "[{\"ade\": \"aplastic anemia\", \"drug\": \"lenalidomide\"}]",
"role": "assistant"
}
] |
Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.
|
[
{
"ade": "bronchospasm",
"drug": "Zoledronic acid"
},
{
"ade": "carpopedal spasm",
"drug": "Zoledronic acid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.",
"role": "user"
},
{
"content": "[{\"ade\": \"bronchospasm\", \"drug\": \"Zoledronic acid\"}, {\"ade\": \"carpopedal spasm\", \"drug\": \"Zoledronic acid\"}]",
"role": "assistant"
}
] |
Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.
|
[
{
"ade": "minor neurological and gastrointestinal complaints",
"drug": "dapsone"
},
{
"ade": "severe hypoalbuminemia without proteinuria",
"drug": "dapsone"
},
{
"ade": "toxic hepatitis",
"drug": "dapsone"
},
{
"ade": "leukopenia",
"drug": "dapsone"
},
{
"ade": "peripheral neuropathy",
"drug": "dapsone"
},
{
"ade": "cutaneous eruptions",
"drug": "dapsone"
},
{
"ade": "an infectious mononucleosis-like syndrome",
"drug": "dapsone"
},
{
"ade": "agranulocytosis",
"drug": "dapsone"
},
{
"ade": "nephrotic syndrome",
"drug": "dapsone"
},
{
"ade": "psychosis",
"drug": "dapsone"
},
{
"ade": "renal papillary necrosis",
"drug": "dapsone"
},
{
"ade": "cholestatic jaundice",
"drug": "dapsone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",
"role": "user"
},
{
"content": "[{\"ade\": \"minor neurological and gastrointestinal complaints\", \"drug\": \"dapsone\"}, {\"ade\": \"severe hypoalbuminemia without proteinuria\", \"drug\": \"dapsone\"}, {\"ade\": \"toxic hepatitis\", \"drug\": \"dapsone\"}, {\"ade\": \"leukopenia\", \"drug\": \"dapsone\"}, {\"ade\": \"peripheral neuropathy\", \"drug\": \"dapsone\"}, {\"ade\": \"cutaneous eruptions\", \"drug\": \"dapsone\"}, {\"ade\": \"an infectious mononucleosis-like syndrome\", \"drug\": \"dapsone\"}, {\"ade\": \"agranulocytosis\", \"drug\": \"dapsone\"}, {\"ade\": \"nephrotic syndrome\", \"drug\": \"dapsone\"}, {\"ade\": \"psychosis\", \"drug\": \"dapsone\"}, {\"ade\": \"renal papillary necrosis\", \"drug\": \"dapsone\"}, {\"ade\": \"cholestatic jaundice\", \"drug\": \"dapsone\"}]",
"role": "assistant"
}
] |
Atrial fibrillation following methylprednisolone pulse therapy.
|
[
{
"ade": "Atrial fibrillation",
"drug": "methylprednisolone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Atrial fibrillation following methylprednisolone pulse therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Atrial fibrillation\", \"drug\": \"methylprednisolone\"}]",
"role": "assistant"
}
] |
A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.
|
[
{
"ade": "proteinuria",
"drug": "temsirolimus"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.",
"role": "user"
},
{
"content": "[{\"ade\": \"proteinuria\", \"drug\": \"temsirolimus\"}]",
"role": "assistant"
}
] |
Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.
|
[
{
"ade": "vancomycin toxicity",
"drug": "vancomycin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Management of hypophosphatemia induced by high-flux hemodiafiltration for the treatment of vancomycin toxicity: intravenous phosphorus therapy versus use of a phosphorus-enriched dialysate.",
"role": "user"
},
{
"content": "[{\"ade\": \"vancomycin toxicity\", \"drug\": \"vancomycin\"}]",
"role": "assistant"
}
] |
Esophageal spasm following propranolol overdose relieved by glucagon.
|
[
{
"ade": "Esophageal spasm",
"drug": "propranolol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Esophageal spasm following propranolol overdose relieved by glucagon.",
"role": "user"
},
{
"content": "[{\"ade\": \"Esophageal spasm\", \"drug\": \"propranolol\"}]",
"role": "assistant"
}
] |
She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.
|
[
{
"ade": "severe urticarial rash",
"drug": "Enoxaparin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: She developed a severe urticarial rash 3 weeks following initiation of therapy with Enoxaparin.",
"role": "user"
},
{
"content": "[{\"ade\": \"severe urticarial rash\", \"drug\": \"Enoxaparin\"}]",
"role": "assistant"
}
] |
To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.
|
[
{
"ade": "granulomatous reaction",
"drug": "calcium hydroxylapatite"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: To our knowledge, this is the first granulomatous reaction described after calcium hydroxylapatite injection.",
"role": "user"
},
{
"content": "[{\"ade\": \"granulomatous reaction\", \"drug\": \"calcium hydroxylapatite\"}]",
"role": "assistant"
}
] |
A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.
|
[
{
"ade": "erythroderma",
"drug": "phenytoin"
},
{
"ade": "pinhead-sized facial pustules",
"drug": "phenytoin"
},
{
"ade": "abnormal liver function tests",
"drug": "phenytoin"
},
{
"ade": "phenytoin hypersensitivity syndrome",
"drug": "phenytoin"
},
{
"ade": "tibial and facial oedema",
"drug": "phenytoin"
},
{
"ade": "fever",
"drug": "phenytoin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A patient is described with the characteristic features of phenytoin hypersensitivity syndrome (PHS) including fever, erythroderma, tibial and facial oedema, pinhead-sized facial pustules and abnormal liver function tests.",
"role": "user"
},
{
"content": "[{\"ade\": \"erythroderma\", \"drug\": \"phenytoin\"}, {\"ade\": \"pinhead-sized facial pustules\", \"drug\": \"phenytoin\"}, {\"ade\": \"abnormal liver function tests\", \"drug\": \"phenytoin\"}, {\"ade\": \"phenytoin hypersensitivity syndrome\", \"drug\": \"phenytoin\"}, {\"ade\": \"tibial and facial oedema\", \"drug\": \"phenytoin\"}, {\"ade\": \"fever\", \"drug\": \"phenytoin\"}]",
"role": "assistant"
}
] |
The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.
|
[
{
"ade": "erythema multiforme",
"drug": "sulfonamides"
},
{
"ade": "Stevens-Johnson syndrome",
"drug": "sulfonamides"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The sulfonamides are the best verified drug-trigger for erythema multiforme and Stevens-Johnson syndrome.",
"role": "user"
},
{
"content": "[{\"ade\": \"erythema multiforme\", \"drug\": \"sulfonamides\"}, {\"ade\": \"Stevens-Johnson syndrome\", \"drug\": \"sulfonamides\"}]",
"role": "assistant"
}
] |
This was accepted as evidence for propranolol being the cause of this conduction disorder.
|
[
{
"ade": "conduction disorder",
"drug": "propranolol"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This was accepted as evidence for propranolol being the cause of this conduction disorder.",
"role": "user"
},
{
"content": "[{\"ade\": \"conduction disorder\", \"drug\": \"propranolol\"}]",
"role": "assistant"
}
] |
Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.
|
[
{
"ade": "urological symptoms",
"drug": "ketamine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Presentation of three palliative care patients who were given ketamine as an analgesic and subsequently developed significant and debilitating urological symptoms.",
"role": "user"
},
{
"content": "[{\"ade\": \"urological symptoms\", \"drug\": \"ketamine\"}]",
"role": "assistant"
}
] |
The authors report one case of incomplete posterior hyaloid detachment (PHD) following intravitreal pegaptanib to treat DME.
|
[
{
"ade": "incomplete posterior hyaloid detachment",
"drug": "pegaptanib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The authors report one case of incomplete posterior hyaloid detachment (PHD) following intravitreal pegaptanib to treat DME.",
"role": "user"
},
{
"content": "[{\"ade\": \"incomplete posterior hyaloid detachment\", \"drug\": \"pegaptanib\"}]",
"role": "assistant"
}
] |
A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.
|
[
{
"ade": "retroperitoneal fibrosis",
"drug": "methysergide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 25-year-old woman sought medical attention because of iliocaval manifestations of retroperitoneal fibrosis while she was taking methysergide.",
"role": "user"
},
{
"content": "[{\"ade\": \"retroperitoneal fibrosis\", \"drug\": \"methysergide\"}]",
"role": "assistant"
}
] |
The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.
|
[
{
"ade": "focal segmental glomerulosclerosis",
"drug": "IFNalpha"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNalpha.",
"role": "user"
},
{
"content": "[{\"ade\": \"focal segmental glomerulosclerosis\", \"drug\": \"IFNalpha\"}]",
"role": "assistant"
}
] |
Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.
|
[
{
"ade": "liver injury",
"drug": "methyldopa"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Such a rapid and relentless progression of methyldopa-induced liver injury is undoubtedly rare, but it may be prevented by careful supervision of patients who exhibit liver function abnormalities early in the course of therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"liver injury\", \"drug\": \"methyldopa\"}]",
"role": "assistant"
}
] |
Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.
|
[
{
"ade": "Clinical, spectroscopic, and imaging abnormalities",
"drug": "metronidazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Clinical, spectroscopic, and imaging abnormalities resolved with discontinuation of metronidazole.",
"role": "user"
},
{
"content": "[{\"ade\": \"Clinical, spectroscopic, and imaging abnormalities\", \"drug\": \"metronidazole\"}]",
"role": "assistant"
}
] |
Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.
|
[
{
"ade": "cardiovascular collapse",
"drug": "Flecainide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Flecainide overdose can rapidly result in profound cardiovascular collapse, and is associated with a relatively high mortality.",
"role": "user"
},
{
"content": "[{\"ade\": \"cardiovascular collapse\", \"drug\": \"Flecainide\"}]",
"role": "assistant"
}
] |
Methimazole-associated cholestatic liver injury: case report and brief literature review.
|
[
{
"ade": "cholestatic liver injury",
"drug": "Methimazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Methimazole-associated cholestatic liver injury: case report and brief literature review.",
"role": "user"
},
{
"content": "[{\"ade\": \"cholestatic liver injury\", \"drug\": \"Methimazole\"}]",
"role": "assistant"
}
] |
Cardiorespiratory toxicity due to miconazole.
|
[
{
"ade": "Cardiorespiratory toxicity",
"drug": "miconazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cardiorespiratory toxicity due to miconazole.",
"role": "user"
},
{
"content": "[{\"ade\": \"Cardiorespiratory toxicity\", \"drug\": \"miconazole\"}]",
"role": "assistant"
}
] |
This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.
|
[
{
"ade": "hypothyroidism",
"drug": "amiodarone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: This is the first report on the histopathological findings of thyroid tissue from a patient with amiodarone-induced hypothyroidism.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypothyroidism\", \"drug\": \"amiodarone\"}]",
"role": "assistant"
}
] |
Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.
|
[
{
"ade": "Pellagra encephalopathy",
"drug": "isoniazid"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.",
"role": "user"
},
{
"content": "[{\"ade\": \"Pellagra encephalopathy\", \"drug\": \"isoniazid\"}]",
"role": "assistant"
}
] |
Cerebral edema associated with Gliadel wafers: two case studies.
|
[
{
"ade": "Cerebral edema",
"drug": "Gliadel"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Cerebral edema associated with Gliadel wafers: two case studies.",
"role": "user"
},
{
"content": "[{\"ade\": \"Cerebral edema\", \"drug\": \"Gliadel\"}]",
"role": "assistant"
}
] |
Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.
|
[
{
"ade": "Sudden cardiac death",
"drug": "clozapine"
},
{
"ade": "hypersensitivity myocarditis",
"drug": "clozapine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"Sudden cardiac death\", \"drug\": \"clozapine\"}, {\"ade\": \"hypersensitivity myocarditis\", \"drug\": \"clozapine\"}]",
"role": "assistant"
}
] |
A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.
|
[
{
"ade": "bullous drug reaction",
"drug": "sulfonamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.",
"role": "user"
},
{
"content": "[{\"ade\": \"bullous drug reaction\", \"drug\": \"sulfonamide\"}]",
"role": "assistant"
}
] |
Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).
|
[
{
"ade": "hemolytic-uremic syndrome",
"drug": "Mitomycin C"
},
{
"ade": "HUS",
"drug": "MMC"
},
{
"ade": "hemolytic-uremic syndrome",
"drug": "MMC"
},
{
"ade": "HUS",
"drug": "Mitomycin C"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).",
"role": "user"
},
{
"content": "[{\"ade\": \"hemolytic-uremic syndrome\", \"drug\": \"Mitomycin C\"}, {\"ade\": \"HUS\", \"drug\": \"MMC\"}, {\"ade\": \"hemolytic-uremic syndrome\", \"drug\": \"MMC\"}, {\"ade\": \"HUS\", \"drug\": \"Mitomycin C\"}]",
"role": "assistant"
}
] |
The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.
|
[
{
"ade": "abdominal pain",
"drug": "vasopressin"
},
{
"ade": "collapse",
"drug": "vasopressin"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The condition should be suspected in patients who develop unexplained abdominal pain or collapse following vasopressin treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"abdominal pain\", \"drug\": \"vasopressin\"}, {\"ade\": \"collapse\", \"drug\": \"vasopressin\"}]",
"role": "assistant"
}
] |
Methimazole-induced aplastic anemia in third exposure: successful treatment with recombinant human granulocyte colony-stimulating factor.
|
[
{
"ade": "aplastic anemia",
"drug": "Methimazole"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Methimazole-induced aplastic anemia in third exposure: successful treatment with recombinant human granulocyte colony-stimulating factor.",
"role": "user"
},
{
"content": "[{\"ade\": \"aplastic anemia\", \"drug\": \"Methimazole\"}]",
"role": "assistant"
}
] |
Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.
|
[
{
"ade": "Pulmonary fibrosis",
"drug": "CCNU"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.",
"role": "user"
},
{
"content": "[{\"ade\": \"Pulmonary fibrosis\", \"drug\": \"CCNU\"}]",
"role": "assistant"
}
] |
A paradoxical ocular effect of brimonidine.
|
[
{
"ade": "paradoxical ocular effect",
"drug": "brimonidine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A paradoxical ocular effect of brimonidine.",
"role": "user"
},
{
"content": "[{\"ade\": \"paradoxical ocular effect\", \"drug\": \"brimonidine\"}]",
"role": "assistant"
}
] |
DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.
|
[
{
"ade": "tuberculous uveitis",
"drug": "etanercept"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: DISCUSSION: To our knowledge this is the first reported case of tuberculous uveitis following treatment with etanercept.",
"role": "user"
},
{
"content": "[{\"ade\": \"tuberculous uveitis\", \"drug\": \"etanercept\"}]",
"role": "assistant"
}
] |
CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.
|
[
{
"ade": "nonconvulsive status epilepticus",
"drug": "ifosfamide"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.",
"role": "user"
},
{
"content": "[{\"ade\": \"nonconvulsive status epilepticus\", \"drug\": \"ifosfamide\"}]",
"role": "assistant"
}
] |
Gemcitabine-related radiation recall preferentially involves internal tissue and organs.
|
[
{
"ade": "radiation recall",
"drug": "Gemcitabine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Gemcitabine-related radiation recall preferentially involves internal tissue and organs.",
"role": "user"
},
{
"content": "[{\"ade\": \"radiation recall\", \"drug\": \"Gemcitabine\"}]",
"role": "assistant"
}
] |
In this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylating agents, and which were treated with long-term hydroxyurea therapy, are described.
|
[
{
"ade": "AL",
"drug": "hydroxyurea"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: In this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylating agents, and which were treated with long-term hydroxyurea therapy, are described.",
"role": "user"
},
{
"content": "[{\"ade\": \"AL\", \"drug\": \"hydroxyurea\"}]",
"role": "assistant"
}
] |
The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.
|
[
{
"ade": "hypothermia",
"drug": "risperidone"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The diagnosis of hypothermia was delayed until it was apparent for several days but resolved with the discontinuation of risperidone and continuation of clozapine.",
"role": "user"
},
{
"content": "[{\"ade\": \"hypothermia\", \"drug\": \"risperidone\"}]",
"role": "assistant"
}
] |
The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.
|
[
{
"ade": "neuroleptic malignant extrapyramidal syndrome",
"drug": "thioridazine"
},
{
"ade": "lithium toxicity",
"drug": "lithium"
},
{
"ade": "lithium toxicity",
"drug": "thioridazine"
},
{
"ade": "neuroleptic malignant extrapyramidal syndrome",
"drug": "lithium"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.",
"role": "user"
},
{
"content": "[{\"ade\": \"neuroleptic malignant extrapyramidal syndrome\", \"drug\": \"thioridazine\"}, {\"ade\": \"lithium toxicity\", \"drug\": \"lithium\"}, {\"ade\": \"lithium toxicity\", \"drug\": \"thioridazine\"}, {\"ade\": \"neuroleptic malignant extrapyramidal syndrome\", \"drug\": \"lithium\"}]",
"role": "assistant"
}
] |
We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.
|
[
{
"ade": "skin manifestations",
"drug": "erlotinib"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We describe a case of a man treated with an EGFR-inhibitor (erlotinib) for a cell lung cancer who developed skin manifestations localized in an uncommon area and with an atypical evolution.",
"role": "user"
},
{
"content": "[{\"ade\": \"skin manifestations\", \"drug\": \"erlotinib\"}]",
"role": "assistant"
}
] |
Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.
|
[
{
"ade": "ulcerative colitis",
"drug": "Sulfasalazine"
},
{
"ade": "ulcerative colitis",
"drug": "sulfasalazine"
},
{
"ade": "lung disorder",
"drug": "Sulfasalazine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.",
"role": "user"
},
{
"content": "[{\"ade\": \"ulcerative colitis\", \"drug\": \"Sulfasalazine\"}, {\"ade\": \"ulcerative colitis\", \"drug\": \"sulfasalazine\"}, {\"ade\": \"lung disorder\", \"drug\": \"Sulfasalazine\"}]",
"role": "assistant"
}
] |
METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.
|
[
{
"ade": "pseudoporphyria",
"drug": "oxaprozin"
},
{
"ade": "pseudoporphyria",
"drug": "naproxen"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: METHODS: We report two cases of pseudoporphyria caused by naproxen and oxaprozin.",
"role": "user"
},
{
"content": "[{\"ade\": \"pseudoporphyria\", \"drug\": \"oxaprozin\"}, {\"ade\": \"pseudoporphyria\", \"drug\": \"naproxen\"}]",
"role": "assistant"
}
] |
An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.
|
[
{
"ade": "lost vision",
"drug": "Bromocryptine"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.",
"role": "user"
},
{
"content": "[{\"ade\": \"lost vision\", \"drug\": \"Bromocryptine\"}]",
"role": "assistant"
}
] |
A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.
|
[
{
"ade": "acute renal failure",
"drug": "enalapril"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A 35-year-old nephrotic man developed acute renal failure with serum creatinine to 1543 micromol/l after a month of therapy with enalapril.",
"role": "user"
},
{
"content": "[{\"ade\": \"acute renal failure\", \"drug\": \"enalapril\"}]",
"role": "assistant"
}
] |
We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).
|
[
{
"ade": "renal failure",
"drug": "HDMTX"
},
{
"ade": "renal failure",
"drug": "methotrexate"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).",
"role": "user"
},
{
"content": "[{\"ade\": \"renal failure\", \"drug\": \"HDMTX\"}, {\"ade\": \"renal failure\", \"drug\": \"methotrexate\"}]",
"role": "assistant"
}
] |
A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.
|
[
{
"ade": "melanonychia",
"drug": "pemetrexed"
},
{
"ade": "onycholysis",
"drug": "pemetrexed"
}
] |
[
{
"content": "Extract all adverse drug effect (ADE) relationships from the sentence. ### TEXT: A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.",
"role": "user"
},
{
"content": "[{\"ade\": \"melanonychia\", \"drug\": \"pemetrexed\"}, {\"ade\": \"onycholysis\", \"drug\": \"pemetrexed\"}]",
"role": "assistant"
}
] |
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