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25883103 | results | There was no significant difference in demographic parameters ( P > @ ) . | 13 |
25883103 | results | There were no significant differences in postoperative nausea and vomiting , otalgia , trismus , fever , or halitosis between the groups ( P > @ ) . | 14 |
25883103 | conclusions | Preemptive montelukast can be used safely to reduce the serious pain caused by tonsillectomy in children . | 15 |
24318863 | objective | Metastatic colon cancer patients are treated with the chemotherapy regimens , FOLFOX and FOLFIRI , in either order . | 0 |
24318863 | objective | So far , we can not predict the response of chemotherapeutic agent , so it is necessary to find which regimen is adequate before starting chemotherapy . | 1 |
24318863 | methods | Enrolled patients are randomized into either conventional treatment or planned treatment preceded by pretreatment genetic analysis . | 2 |
24318863 | methods | Blood samples of patients in planned treatment group ( N = @ ) were analyzed for the genetic polymorphism before selection of chemotherapeutic agents . | 3 |
24318863 | methods | Target genes were XPD-@ , GSTP-@-@ , XRCC@-@ for oxaliplatin , UGT@A@ for irinotecan . | 4 |
24318863 | methods | The response was measured by computed tomographic scan after completion of three cycles of chemotherapy . | 5 |
24318863 | results | Overall response rate was significantly higher in planned group ( @ % vs. @ % , P = @ ) . | 6 |
24318863 | results | In FOLFOX group , response rate was significantly improved in the planned patients ( @ % vs. @ % , P = @ ) . | 7 |
24318863 | results | In FOLFIRI group , the difference did n't reach statistical significance ( @ % vs. @ % , P = @ ) . | 8 |
24318863 | conclusions | We found significantly improved response rates in the chemotherapy of metastatic colon cancer by pretreatment genetic analysis , especially in FOLFOX group . | 9 |
25872502 | background | Cardiac arrest causes ischaemic brain injury . | 0 |
25872502 | background | Arterial carbon dioxide tension ( PaCO@ ) is a major determinant of cerebral blood flow . | 1 |
25872502 | background | Thus , mild hypercapnia in the @ h following cardiac arrest may increase cerebral blood flow and attenuate such injury . | 2 |
25872502 | background | We describe the Carbon Control and Cardiac Arrest ( CCC ) trial . | 3 |
25872502 | methods | The CCC trial is a pilot multicentre feasibility , safety and biological efficacy randomized controlled trial recruiting adult cardiac arrest patients admitted to the intensive care unit after return of spontaneous circulation . | 4 |
25872502 | methods | At admission , using concealed allocation , participants are randomized to @ h of either normocapnia ( PaCO@ @ to @ mmHg ) or mild hypercapnia ( PaCO@ @ to @ mmHg ) . | 5 |
25872502 | methods | Key feasibility outcomes are recruitment rate and protocol compliance rate . | 6 |
25872502 | methods | The primary biological efficacy and biological safety measures are the between-groups difference in serum neuron-specific enolase and S@b protein levels at @ h , @ h and @ h. Secondary outcome measure include adverse events , in-hospital mortality , and neurological assessment at @ months . | 7 |
25872502 | conclusions | The trial commenced in December @ and , when completed , will provide clinical evidence as to whether targeting mild hypercapnia for @ h following intensive care unit admission for cardiac arrest patients is feasible and safe and whether it results in decreased concentrations of neurological injury biomarkers compared with normocapnia . | 8 |
25872502 | conclusions | Trial results will also be used to determine whether a phase IIb study powered for survival at @ days is feasible and justified . | 9 |
24226487 | background | For decades thiopental has been considered as the hypnotic drug of choice for intracranial surgery . | 0 |
24226487 | background | However , total intravenous anesthesia performed with thiopental is associated with delayed recovery , whereas early post-operative neurological evaluation is critical . | 1 |
24226487 | background | For this reason , target controlled infusion ( TCI ) of propofol is increasingly used for maintenance of anesthesia . | 2 |
24226487 | background | However , a thiopental TCI has never been assessed for this purpose . | 3 |
24226487 | background | We tested the hypothesis that a thiopental TCI provides an acceptable way to achieve early recovery compared to a propofol TCI during supratentorial surgery . | 4 |
24226487 | methods | Eighty patients undergoing elective craniotomy for a supratentorial tumor were randomized to receive either a propofol TCI ( group P ) or a thiopental TCI ( group T ) . | 5 |
24226487 | methods | Both groups received a sufentanil TCI and the bispectral index was monitored . | 6 |
24226487 | methods | The primary end-point was time to tracheal extubation . | 7 |
24226487 | methods | Secondary end-points were per - and post-operative hemodynamics as well as respiratory and recovery parameters . | 8 |
24226487 | methods | Assessment of study end-points was performed by an intensive care specialist blinded ( like the patient ) to the received hypnotic . | 9 |
24226487 | results | Time to extubation was significantly ( P < @ ) shorter in group P ( median @ minutes ; interquartile range @-@ minutes ) than in group T ( median @ minutes ; interquartile range @-@ minutes ) . | 10 |
24226487 | results | Similarly , the recovery parameters were significantly better in group P than in group T. | 11 |
24226487 | results | There was no difference between groups in terms of patient characteristics and hemodynamic parameters . | 12 |
24226487 | conclusions | Even with TCI and bispectral index monitoring , thiopental is associated with an inappropriate delayed recovery from supratentorial surgery compared to propofol TCI . | 13 |
25539560 | objective | To investigate the effects of conservative therapy applied before arthroscopic subacromial decompression on the clinical outcome in patients with stage @ shoulder impingement syndrome . | 0 |
25539560 | methods | Sixty-eight patients having stage @ shoulder impingement syndrome and treated with arthroscopic subacromial decompression were included in the study . | 1 |
25539560 | methods | We divided these patients into @ groups , whereby @ ( @ % ) patients received conservative therapy before arthroscopic subacromial decompression and @ ( @ % ) patients did not receive conservative therapy . | 2 |
25539560 | methods | We compared both groups in terms of the the Constant , UCLA , and VAS scores for shoulder pain before and after arthroscopic subacromial decompression . | 3 |
25539560 | results | Constant , UCLA , and VAS scores were statistically significantly improved in both groups after arthroscopic subacromial decompression ( P < @ ) . | 4 |
25539560 | results | Constant , UCLA , and VAS scores before arthroscopic subacromial decompression were statistically better in Group @ than in Group @ ( P < @ ) . | 5 |
25539560 | results | No statistically significant difference was found between the groups in terms of Constant , UCLA , and VAS scores after arthroscopic subacromial decompression ( P > @ ) . | 6 |
25539560 | conclusions | Conservative therapy applied in patients with stage @ shoulder impingement syndrome before arthroscopic subacromial decompression does not have a positive contribution on the clinical outcome after arthroscopic subacromial decompression . | 7 |
24401051 | background | Obstructive sleep apnea is associated with considerable health risks . | 0 |
24401051 | background | Although continuous positive airway pressure ( CPAP ) can mitigate these risks , effectiveness can be reduced by inadequate adherence to treatment . | 1 |
24401051 | background | We evaluated the clinical safety and effectiveness of upper-airway stimulation at @ months for the treatment of moderate-to-severe obstructive sleep apnea . | 2 |
24401051 | methods | Using a multicenter , prospective , single-group , cohort design , we surgically implanted an upper-airway stimulation device in patients with obstructive sleep apnea who had difficulty either accepting or adhering to CPAP therapy . | 3 |
24401051 | methods | The primary outcome measures were the apnea-hypopnea index ( AHI ; the number of apnea or hypopnea events per hour , with a score of @ indicating moderate-to-severe apnea ) and the oxygen desaturation index ( ODI ; the number of times per hour of sleep that the blood oxygen level drops by @ percentage points from baseline ) . | 4 |
24401051 | methods | Secondary outcome measures were the Epworth Sleepiness Scale , the Functional Outcomes of Sleep Questionnaire ( FOSQ ) , and the percentage of sleep time with the oxygen saturation less than @ % . | 5 |
24401051 | methods | Consecutive participants with a response were included in a randomized , controlled therapy-withdrawal trial . | 6 |
24401051 | results | The study included @ participants ; @ % were men . | 7 |
24401051 | results | The mean age was @ years , and the mean body-mass index ( the weight in kilograms divided by the square of the height in meters ) was @ . | 8 |
24401051 | results | The median AHI score at @ months decreased @ % , from @ events per hour to @ events per hour ( P < @ ) ; the ODI score decreased @ % , from @ events per hour to @ events per hour ( P < @ ) . | 9 |
24401051 | results | Secondary outcome measures showed a reduction in the effects of sleep apnea and improved quality of life . | 10 |
24401051 | results | In the randomized phase , the mean AHI score did not differ significantly from the @-month score in the nonrandomized phase among the @ participants in the therapy-maintenance group ( @ and @ events per hour , respectively ) ; the AHI score was significantly higher ( indicating more severe apnea ) among the @ participants in the therapy-withdrawal group ( @ vs. @ events per hour , P < @ ) . | 11 |
24401051 | results | The ODI results followed a similar pattern . | 12 |
24401051 | results | The rate of procedure-related serious adverse events was less than @ % . | 13 |
24401051 | conclusions | In this uncontrolled cohort study , upper-airway stimulation led to significant improvements in objective and subjective measurements of the severity of obstructive sleep apnea . | 14 |
24401051 | conclusions | ( Funded by Inspire Medical Systems ; STAR ClinicalTrials.gov number , NCT@ . ) | 15 |
26126563 | objective | To identify facilitators and barriers to clinical trial implementation in Aboriginal health services . | 0 |
26126563 | methods | Indepth interview study with thematic analysis . | 1 |
26126563 | methods | Six Aboriginal community-controlled health services and one government-run service involved in the Kanyini Guidelines Adherence with the Polypill ( KGAP ) study , a pragmatic randomised controlled trial that aimed to improve adherence to indicated drug treatments for people at high risk of cardiovascular disease . | 2 |
26126563 | methods | @ health care providers and @ Aboriginal and Torres Strait Islander patients . | 3 |
26126563 | results | A fundamental enabler was that participants considered the research to be governed and endorsed by the local health service . | 4 |
26126563 | results | That the research was perceived to address a health priority for communities was also highly motivating for both providers and patients . | 5 |
26126563 | results | Enlisting the support of Aboriginal and Torres Strait Islander staff champions who were visible to the community as the main source of information about the trial was particularly important . | 6 |
26126563 | results | The major implementation barrier for staff was balancing their service delivery roles with adherence to often highly demanding trial-related procedures . | 7 |
26126563 | results | This was partially alleviated by the research team 's provision of onsite support and attempts to make trial processes more streamlined . | 8 |
26126563 | results | Although more intensive support was highly desired , there were usually insufficient resources to provide this . | 9 |
26126563 | conclusions | Despite strong community and health service support , major investments in time and resources are needed to ensure successful implementation and minimal disruption to already overstretched , routine services . | 10 |
26126563 | conclusions | Trial budgets will necessarily be inflated as a result . | 11 |
26126563 | conclusions | Funding agencies need to consider these additional resource demands when supporting trials of a similar nature . | 12 |
24693629 | objective | To compare the effect of incomplete caries removal ( ICR ) and indirect pulp capping ( IPC ) with calcium hydroxide ( CH ) or an inert material ( wax ) on color , consistency and contamination of the remaining dentin of primary molars . | 0 |
24693629 | methods | This double-blind , parallel-design , randomized controlled trial included @ children presenting one primary molar with deep caries lesion . | 1 |
24693629 | methods | Children were randomly assigned after ICR to receive IPC with CH or wax . | 2 |
24693629 | methods | All teeth were then restored with resin composite . | 3 |
24693629 | methods | Baseline dentin color and consistency were evaluated after ICR , and dentin samples were collected for contamination analyses using scanning electron microscopy . | 4 |
24693629 | methods | After @ months , restorations were removed and the three parameters were re-evaluated . | 5 |
24693629 | methods | In both groups , dentin became significantly darker after @ months . | 6 |
24693629 | results | No cases of yellow dentin were observed after @ months with CH compared to @ % of the wax cases ( P < @ ) . | 7 |
24693629 | results | A statistically significant difference over time was observed only for CH regarding consistency . | 8 |
24693629 | results | CH stimulated a dentin hardening process in a statistically higher number of cases than wax ( @ % vs. @ % ; P = @ ) . | 9 |
24693629 | results | Contamination changed significantly over time in CH and wax without significant difference between groups . | 10 |
24693629 | results | It was concluded that CH and wax arrested the carious process of the remaining carious dentin after indirect pulp capping , but CH showed superior dentin color and consistency after @ months . | 11 |
24996519 | background | In literature there is a general consensus that the use of the mirror improves proprioception . | 0 |
24996519 | background | During rehabilitation the mirror is an important instrument to improve stability . | 1 |
24996519 | background | In some sports , such as dancing , mirrors are widely used during training . | 2 |
24996519 | background | The purpose of this study is to evaluate the effectiveness of the use of a mirror on balance in young dancers . | 3 |
24996519 | background | Sixty-four young dancers ( ranging from @-@ years ) were included in this study . | 4 |
24996519 | background | Thirty-two attending lessons with a mirror ( mirror - group ) were compared to @ young dancers that attended the same lessons without a mirror ( non-mirror group ) . | 5 |
24996519 | background | Balance was evaluated by BESS ( Balance Error Scoring System ) , which consists of three stances ( double limb , single limb , and tandem ) on two surfaces ( firm and foam ) . | 6 |
24996519 | background | The errors were assessed at each stance and summed to create the two subtotal scores ( firm and foam surface ) and the final total score ( BESS ) . | 7 |
24996519 | background | The BESS was performed at recruitment ( T@ ) and after @months of dance lessons ( T@ ) . | 8 |
24996519 | results | The repeated measures ANOVA analysis showed that for the BESS total score there is a difference due to the time ( F = @ ; p < @ ) . | 9 |
24996519 | results | No other differences due to the group or to the time of measurement were found ( p > @ ) . | 10 |
24996519 | results | The analysis of the multiple regression model showed the influence of the values at T@ for every BESS items and the dominance of limb for stability on an unstable surface standing on one or two legs . | 11 |
24996519 | conclusions | These preliminary results suggest that the use of a mirror in a ballet classroom does not improve balance acquisition of the dancer . | 12 |
24996519 | conclusions | On the other hand , improvement found after @months confirms that at the age of the dancers studied motor skills and balance can easily be trained and improved . | 13 |