abstract_id
stringlengths 8
8
| label
stringclasses 5
values | text
stringlengths 1
1.39k
| sentence_id
int64 0
30
|
|---|---|---|---|
25440306 | objective | Long-term follow-up studies documenting maintenance of treatment effects are fewin adolescent anorexia nervosa ( AN ) . | 0 |
25440306 | objective | This exploratory study reports relapse from full remission and attainment of remission during a @-year open follow-up period using a convenience sample of a subgroup of @ % ( n = @ ) from an original cohort of @ participants who completed a randomized clinical trial comparing family-based therapy ( FBT ) and adolescent-focused individual therapy ( AFT ) . | 1 |
25440306 | methods | Follow-up assessments were completed up to @years posttreatment ( average , @ years ) . | 2 |
25440306 | methods | Available participants completed the Eating Disorder Examination as well as self-report measures of self-esteem and depression at @ to @ years posttreatment . | 3 |
25440306 | results | Two participants ( @ % ) relapsed ( FBT : n = @ , @ % ; AFT : n = @ , @ % ) , on average @ years ( SD = @ years ) after remission was achieved at @-year follow-up . | 4 |
25440306 | results | Ten new participants ( @ % ) achieved remission ( FBT : n = @ , @ % ; AFT : n = @ , @ % ) . | 5 |
25440306 | results | Mean time to remission for this group was @ years ( SD = @ years ) from @-year follow-up . | 6 |
25440306 | results | There were no differences based on treatment group assignment in either relapse from full remission or new remission during long-term follow-up . | 7 |
25440306 | results | Other psychopathology was stable over time . | 8 |
25440306 | conclusions | There were few changes in the clinical presentation of participants who were assessed at long-term follow-up . | 9 |
25440306 | conclusions | These data suggest that outcomes are generally stable posttreatment regardless of treatment type once remission is achieved . | 10 |
25440306 | conclusions | Clinical trial registration information-Effectiveness of Family-Based Versus Individual Psychotherapy in Treating Adolescents With Anorexia Nervosa ; http://www.clinicaltrials.gov/; NCT@ . | 11 |
24754891 | background | Coronary artery bypass grafting using the radial artery has , since the @s , gone through a revival . | 0 |
24754891 | background | Observational studies have indicated better long-term patency when using radial arteries . | 1 |
24754891 | background | Therefore , radial artery might be preferred especially in younger patients where long time patency is important . | 2 |
24754891 | background | During the last @years different endoscopic techniques to harvest the radial artery have evolved . | 3 |
24754891 | background | Endoscopic radial artery harvest only requires a small incision near the wrist in contrast to open harvest , which requires an incision from the elbow to the wrist . | 4 |
24754891 | background | However , it is unknown whether the endoscopic technique results in fewer complications or a graft patency comparable to open harvest . | 5 |
24754891 | background | When the radial artery has been harvested , there are two ways to use the radial artery as a graft . | 6 |
24754891 | background | One way is sewing it onto the aorta and another is sewing it onto the mammary artery . | 7 |
24754891 | background | It is unknown which technique is the superior revascularisation technique . | 8 |
24754891 | methods | The NEO Trial is a randomised clinical trial with a @ factorial design . | 9 |
24754891 | methods | We plan to randomise @ participants into four intervention groups : ( @ ) mammario-radial endoscopic group ; ( @ ) aorto-radial endoscopic group ; ( @ ) mammario-radial open surgery group ; and ( @ ) aorto-radial open surgery group.The hand function will be assessed by a questionnaire , a clinical examination , the change in cutaneous sensibility , and the measurement of both sensory and motor nerve conduction velocity at @months postoperatively . | 10 |
24754891 | methods | All the postoperative complications will be registered , and we will evaluate muscular function , scar appearance , vascular supply to the hand , and the graft patency including the patency of the central radial artery anastomosis . | 11 |
24754891 | methods | A patency evaluation by multi-slice computer tomography will be done at one year postoperatively.We expect the nerve conduction studies and the standardised neurological examinations to be able to discriminate differences in hand function comparing endoscopic to open harvest of the radial artery . | 12 |
24754891 | methods | The trial also aims to show if there is any patency difference between mammario-radial compared to aorto-radial revascularisation techniques but this objective is exploratory . | 13 |
24284437 | background | Knowledge of essential amino acid requirements in infants is important because excessive intake of protein can lead to increased long-term morbidity such as obesity . | 0 |
24284437 | background | A deficient intake may lead to suboptimal growth and impaired neurodevelopment . | 1 |
24284437 | background | The current recommended branched-chain amino acid requirements in infants aged @-@ mo are based on the amino acid content of human milk . | 2 |
24284437 | objective | We quantified the requirements for isoleucine , leucine , and valine for term neonates by using the indicator amino acid oxidation method with -LSB- @ - ( @ ) C -RSB- phenylalanine as the indicator . | 3 |
24284437 | methods | Fully enterally fed term infants received randomly graded amounts of isoleucine ( @-@ mg kg ( -@ ) d ( -@ ) ) , leucine ( @-@ mg kg ( -@ ) d ( -@ ) ) , or valine ( @-@ mg kg ( -@ ) d ( -@ ) ) as part of an elemental formula . | 4 |
24284437 | methods | Data are expressed as means SDs . | 5 |
24284437 | results | Eighty-three Asian , term neonates ( mean SD birth weight : @ @ kg ; gestational age : @ @ wk ) were studied at a postnatal age of @ @ d. Mean requirements for isoleucine , leucine , and valine ( measured in boys only ) were @ mg kg ( -@ ) d ( -@ ) ( r ( @ ) = @ , P < @ ) , @ mg kg ( -@ ) d ( -@ ) ( r ( @ ) = @ , P < @ ) , and @ mg kg ( -@ ) d ( -@ ) ( r ( @ ) = @ , P = @ ) , respectively . | 6 |
24284437 | conclusions | Current human milk-based recommendations for isoleucine and valine in term infants aged @-@ mo are correct . | 7 |
24284437 | conclusions | However , the current recommendation for leucine ( @ mg kg ( -@ ) d ( -@ ) ) is higher than the mean requirement of @ mg kg ( -@ ) d ( -@ ) that we determined in this study . | 8 |
24284437 | conclusions | This trial was registered at www.trialregister.nl as NTR@ . | 9 |
25585779 | objective | We wanted to confirm the benefit of mometasone furoate ( MF ) in preventing acute radiation reactions , as shown in a previous study ( Bostrm et al , Radiother Oncol @ ; @:@ -@ ) . | 0 |
25585779 | methods | The study was a double-blind comparison of MF with D ( Diprobase ) , administered daily from the start of radiation therapy for @ weeks in patients receiving breast radiation therapy , @ Gy in @-Gy fractions daily over @ weeks . | 1 |
25585779 | methods | The primary endpoint was mean modified Radiation Therapy Oncology Group ( RTOG ) score . | 2 |
25585779 | results | Mean RTOG scores were significantly less for MF than for D ( P = @ ) . | 3 |
25585779 | results | Maximum RTOG and mean erythema scores were significantly less for MF than for D ( P = @ and P = @ , respectively ) . | 4 |
25585779 | results | The Dermatology Life Quality Index ( DLQI ) score was significantly less for MF than for D at weeks @ and @ when corrected for Hospital Anxiety and Depression ( HAD ) questionnaire scores . | 5 |
25585779 | conclusions | MF cream significantly reduces radiation dermatitis when applied to the breast during and after radiation therapy . | 6 |
25585779 | conclusions | For the first time , we have shown a significantly beneficial effect on quality of life using a validated instrument ( DLQI ) , for a topical steroid cream . | 7 |
25585779 | conclusions | We believe that application of this cream should be the standard of care where radiation dermatitis is expected . | 8 |
24332668 | objective | To compare the interstage cardiac catheterization hemodynamic and angiographic findings between shunt types for the Pediatric Heart Network Single Ventricle Reconstruction trial . | 0 |
24332668 | objective | The trial , which randomized subjects to a modified Blalock-Taussig shunt ( MBTS ) or right ventricle-to-pulmonary artery shunt ( RVPAS ) for the Norwood procedure , demonstrated the RVPAS was associated with a smaller pulmonary artery diameter but superior @-month transplant-free survival . | 1 |
24332668 | methods | We analyzed the pre-stage II catheterization data for the trial subjects . | 2 |
24332668 | methods | The hemodynamic variables and shunt and pulmonary angiographic data were compared between shunt types ; their association with @-month transplant-free survival was also evaluated . | 3 |
24332668 | results | Of @ randomized subjects , @ underwent pre-stage II catheterization . | 4 |
24332668 | results | A smaller size , lower aortic and superior vena cava saturation , and higher ventricular end-diastolic pressure were associated with worse @-month transplant-free survival . | 5 |
24332668 | results | The MBTS group had a lower coronary perfusion pressure ( @ vs @ mm Hg ; P < @ ) and greater pulmonary blood flow/systemic blood flow ratio ( @ vs @ , P = @ ) . | 6 |
24332668 | results | A greater pulmonary blood flow/systemic blood flow ratio increased the risk of death or transplantation only in the RVPAS group ( P = @ ) . | 7 |
24332668 | results | The MBTS group had fewer shunt ( @ % vs @ % , P = @ ) and severe left pulmonary artery ( @ % vs @ % , P = @ ) stenoses , larger mid-main branch pulmonary artery diameters , and greater Nakata indexes ( @ vs @ , P < @ ) . | 8 |
24332668 | conclusions | Compared with the RVPAS subjects , the MBTS subjects had more hemodynamic abnormalities related to shunt physiology , and the RVPAS subjects had more shunt or pulmonary obstruction of a severe degree and inferior pulmonary artery growth at pre-stage II catheterization . | 9 |
24332668 | conclusions | A lower body surface area , greater ventricular end-diastolic pressure , and lower superior vena cava saturation were associated with worse @-month transplant-free survival . | 10 |
24379356 | objective | It has been hypothesized that the development of diabetic polyneuropathy ( DPN ) is due to swelling of the nerve , as well as thickening and stiffening of the surrounding ligaments , causing chronic compression of nerves . | 0 |
24379356 | objective | We aimed to examine the effect of surgical decompression of the tibial nerve on the mean cross-sectional area ( CSA ) . | 1 |
24379356 | methods | We performed a randomized controlled trial of @ subjects with painful DPN diagnosed using the Diabetic Neuropathy Score . | 2 |
24379356 | methods | A computer randomized for the surgery arm of the study . | 3 |
24379356 | methods | A control group consisting of @ healthy subjects was included . | 4 |
24379356 | methods | An experienced sonographer measured the CSA and thickness-to-width ( T/W ) ratio of the tibial nerve , as well as the thickness of the flexor retinaculum . | 5 |
24379356 | results | CSA is significantly larger in patients with painful DPN ( @ @ mm ( @ ) ) than in control subjects ( @ @ mm ( @ ) ) , P = @ . | 6 |
24379356 | results | The T/W ratio in patients with painful DPN is @ and in control subjects @ , P = @ . | 7 |
24379356 | results | Patients with DPN have a significantly thicker retinaculum ( @ mm ) than control subjects ( @ mm ) , P < @ . | 8 |
24379356 | results | Mean follow-up was @ weeks ( range @-@ ) . | 9 |
24379356 | results | Difference between baseline and follow-up in the operated leg was @ mm ( @ ) and in the control leg @ mm ( @ ) , P = @ . | 10 |
24379356 | conclusions | Decompression of the tibial nerve does not result in a significant difference between baseline and follow-up in CSA using ultrasound between the operated and control leg . | 11 |
24379356 | conclusions | Ultrasound measurements show a significantly increased CSA , a significantly thicker retinaculum , and a significantly increased T/W ratio in patients with painful DPN compared with healthy control subjects . | 12 |
24379356 | conclusions | Clinical trial reg . | 13 |
24379356 | conclusions | no . | 14 |
24379356 | conclusions | NTR@ , www.trialregister.nl . | 15 |
25018097 | background | A community-based randomized trial was conducted in Costa Rica to evaluate the HPV-@ / @ AS@-adjuvanted vaccine ( NCT@ ) . | 0 |
25018097 | background | The primary objective was to evaluate efficacy of the vaccine to prevent cervical intraepithelial neoplasia @ or more severe disease ( CIN@ + ) associated with incident HPV-@ / @ cervical infections . | 1 |
25018097 | background | Secondary objectives were to evaluate efficacy against CIN@ + associated with incident cervical infection by any oncogenic HPVs and to evaluate duration of protection against incident cervical infection with HPV-@ / @ . | 2 |
25018097 | background | Vaccine safety and immunogenicity over the @-year follow-up were also evaluated . | 3 |
25018097 | methods | We randomized ( @ HPV arm ; @ control arm ) , vaccinated ( HPV-@ / @ or Hepatitis A ) and followed ( median @ months ) @ healthy women aged @-@ years . | 4 |
25018097 | methods | @ women ( @ HPV arm ; @ control arm ) were included in the according to protocol analysis for efficacy . | 5 |
25018097 | methods | The full cohort was evaluated for safety . | 6 |
25018097 | methods | Immunogenicity was considered on a subset of @ ( HPV-@ ) and @ ( HPV-@ ) women . | 7 |
25018097 | methods | HPV type was assessed by PCR on cervical specimens . | 8 |
25018097 | methods | Immunogenicity was assessed using ELISA and inhibition enzyme immunoassays . | 9 |
25018097 | methods | Disease outcomes were histologically confirmed . | 10 |
25018097 | methods | Vaccine efficacy and @ % confidence intervals ( @ % CI ) were computed . | 11 |
25018097 | results | Vaccine efficacy was @ % ( @ % CI : @-@ @ ; N = @ events total ) against HPV-@ / @ associated CIN@ + , @ % ( @ % CI : @-@ @ ; N = @ events total ) against CIN@ + associated with non-HPV-@ / @ oncogenic HPVs and @ % ( @ % CI : @-@ @ ; N = @ events total ) against CIN@ + irrespective of HPV type . | 12 |
25018097 | results | The vaccine had an acceptable safety profile and induced robust and long-lasting antibody responses . | 13 |
25018097 | conclusions | Our findings confirm the high efficacy and immunogenicity of the HPV-@ / @ vaccine against incident HPV infections and cervical disease associated with HPV-@ / @ and other oncogenic HPV types . | 14 |
25018097 | conclusions | These results will serve as a benchmark to which we can compare future findings from the ongoing extended follow-up of participants in the Costa Rica trial . | 15 |
24736930 | background | There is a long-held concept among spine surgeons that endoscopic lumbar discectomy procedures are reserved for small-contained disc herniation ; @-year follow-up has not been reported . | 0 |
24736930 | background | The purpose of this study is to assess microendoscopic discectomy ( MED ) in patients with large uncontained lumbar disc herniation ( the antero-posterior diameter of the extruded fragment is @-@ mm or more on axial cuts of MRI ) and report long-term outcome . | 1 |
24736930 | methods | One hundred eighty-five patients with MED or standard open discectomy underwent follow-up for @ years . | 2 |
24736930 | methods | Primary ( clinical ) outcomes data included Numerical Rating Scale ( NRS ) for back and leg symptoms and Oswestry Disability Index ( ODI ) to quantify pain and disability , respectively . | 3 |
24736930 | methods | Secondary ( objective ) outcomes data included operative time , blood loss , postoperative analgesics , length of hospital stay , time to return to work , reoperation and complication rate , patient satisfaction index ( PSI ) , and modified ( MacNab ) criteria . | 4 |
24736930 | results | At the end of the follow-up , the leg pain relief was statistically significant for both groups . | 5 |
24736930 | results | NRS back pain , ODI , PSI and MacNab criteria showed significant deterioration for control group . | 6 |
24736930 | results | Secondary outcomes data of MED group were significantly better than the control group . | 7 |
24736930 | conclusions | Large , uncontained , lumbar disc herniations can be sufficiently removed using MED which is an effective alternative to open discectomy procedures with remarkable long-term outcome . | 8 |
24736930 | conclusions | Although the neurological outcome of the two procedures is the same , the morbidity of MED is significantly less than open discectomy . | 9 |
24736930 | conclusions | Maximum benefit can be gained if we adhere to strict selection criteria . | 10 |
24736930 | conclusions | The optimum indication is single - or multi-level radiculopathy secondary to a single-level , large , uncontained , lumbar disc herniation . | 11 |