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25318787 | methods | A total of @ consecutive STEMI patients were prospectively and randomly assigned into two groups : @ patients in the RH group and @ patients in the no RH ( control ) group . | 1 |
25318787 | methods | The serum creatinine ( SCr ) and creatinine clearance ( CCr ) levels were measured on admission and at @ , @ and @ hours after primary PCI . | 2 |
25318787 | methods | The rates of CIN and short-term adverse events were analyzed for each group . | 3 |
25318787 | methods | After surgery , the patients were categorized into four groups according to the Mehran risk score : low ( @ , n = @ ) , moderate ( @-@ , n = @ ) , high ( @-@ , n = @ ) or very high ( @ , n = @ ) . | 4 |
25318787 | results | The incidence of CIN in the RH group was lower than that observed in the control group ( @/@ ; @ % vs. @/@ ; @ % , p < @ ) . | 5 |
25318787 | results | The subgroup analysis showed that the rate of CIN was lower in the moderate ( @/@ ; @ % vs. @/@ ; @ % , p < @ ) and significantly lower in both the high ( @/@ ; @ % vs. @/@ ; @ % , p < @ ) and very high score groups ( @/@ ; @ % vs. @/@ ; @ % , p < @ ) among the RH patients compared to the controls . | 6 |
25318787 | results | At @ , @ and @ hours after PCI , the patients in the RH group exhibited lower SCr levels and higher CCr levels than the patients in the control group ( both p < @ ) . | 7 |
25318787 | results | A lower incidence of in-hospital clinical events was also observed in the RH group . | 8 |
25318787 | conclusions | Remedial hydration decreases the occurrence of CIN and improves the short-term prognosis of STEMI patients undergoing primary PCI . | 9 |
24396280 | background | An increased production of oxidizing species related to reactive oral diseases , such as chronic apical periodontitis , could have systemic implications such as an increase in cardiovascular morbidity . | 0 |
24396280 | background | Based on this consideration , we conducted a prospective study to assess whether subjects affected by chronic periodontitis presented with higher values of oxidative stress than reference values before endodontic treatment , and whether endodontic treatment can reduce the oxidative imbalance and bring it back to normal in these subjects . | 1 |
24396280 | methods | The authors recruited @ groups of patients from private studies and dental clinics : these patients were recruited randomly . | 2 |
24396280 | methods | The oxidative balance in both patients with chronic apical periodontitis ( CAP ) and healthy control patients was determined by measuring the oxidant status , using an identification of the reactive oxygen metabolites ( d-ROMs ) test , while the antioxidant status in these patients was determined using a biological antioxidant potential ( BAP ) test . | 3 |
24396280 | methods | Both these tests were carried on plasma samples taken from enrolled patients . | 4 |
24396280 | methods | Values were measured both before the endodontic treatment of the patients with chronic apical periodontitis , and @ and @ days after treatment , and compared to those obtained from healthy control patients . | 5 |
24396280 | results | It was found that , on recruitment , the patients with chronic apical periodontitis exhibited significantly higher levels of oxidative stress than control patients , as determined by the d-ROMs and BAP tests . | 6 |
24396280 | results | Furthermore , the d-ROMs test values were shown to decrease and the BAP test values to increase over time in patients with chronic apical periodontitis following endodontic therapy . | 7 |
24396280 | results | As the levels of oxidative stress in these patients tended to reduce and return to normal by @ days following treatment . | 8 |
24396280 | conclusions | This study has demonstrated a positive association between chronic apical periodontitis and oxidative stress . | 9 |
24396280 | conclusions | Subjects affected by chronic apical periodontitis are exposed to a condition of oxidative stress , which is extremely dangerous to general health . | 10 |
24396280 | conclusions | Moreover , one can infer from these findings that through proper endodontic therapy , a good oxidative balance can be restored , thereby avoiding the risk of contracting the abovementioned diseases . | 11 |
24731889 | background | Placebo effect has been largely studied and debated in medicine . | 0 |
24731889 | background | Research focused mainly on children and adults but not on newborns . | 1 |
24731889 | background | In osteopathy , few studies documented this effect and no research has been conducted in newborns . | 2 |
24731889 | objective | To assess the presence of placebo effect in newborns using sham osteopathic manipulative treatment . | 3 |
24731889 | methods | Randomized control trial . | 4 |
24731889 | methods | Neonatal Intensive Care Unit in Italy . | 5 |
24731889 | methods | Two groups ( @ patients each ) of preterm infants aged @-@ weeks without medical complications received routine pediatric care and osteopathic sham therapy was administrated to the study group only for the entire period of hospitalization . | 6 |
24731889 | methods | Primary end point was the mean reduction of length of stay at discharge . | 7 |
24731889 | methods | Secondary objective was the change in daily weight gain . | 8 |
24731889 | results | @ newborns entered the study . | 9 |
24731889 | results | No difference between sham and control group was found for the primary outcome length of stay ( @ ; @ ; p = @ ) . | 10 |
24731889 | results | Multivariate analysis showed no difference between study and control group on length of stay . | 11 |
24731889 | results | A negative association was found for gestational age ( -@ ; @ % CI -@ to -@ ; p = @ ) , birth weight ( -@ ; @ % CI -@ to -@ ; p < @ ) and milk volume at study enrollment ( -@ ; @ % CI -@ to -@ ; p = @ ) . | 12 |
24731889 | conclusions | To the best of our knowledge , this study is the first in the field showing no placebo effect on newborns . | 13 |
24731889 | conclusions | Further discussions are opened concerning the age when placebo effect starts . | 14 |
25880933 | background | Clostridium difficile infection ( CDI ) is a leading cause of diarrhoea in health care settings with symptoms ranging from mild and self-limiting to life threatening . | 0 |
25880933 | background | SMT@ is a novel , non-absorbable antibiotic currently under development for the treatment of CDI . | 1 |
25880933 | background | Here we report the results from a Phase I study . | 2 |
25880933 | methods | A double-blind , randomized , placebo-controlled study assessing safety and tolerability of single and multiple oral doses of SMT@ in healthy volunteers . | 3 |
25880933 | methods | Pharmacokinetic assessments included blood and faecal sampling . | 4 |
25880933 | methods | The effect of food on systemic exposure and analysis of the gut microbiota were also included . | 5 |
25880933 | results | Fifty-six healthy male subjects were enrolled . | 6 |
25880933 | results | Following single oral doses of up to @,@ mg in the fasted state , plasma concentrations of SMT@ were generally below the lower limit of quantification . | 7 |
25880933 | results | In the fed state levels ranged from @ to @ ng/mL after single dosing and after repeat dosing at Day @ from @ to @ ng/mL . | 8 |
25880933 | results | Following single and multiple oral doses of SMT@ , mean daily faecal concentrations increased with increasing dose level and were significantly above the typical MIC range for C. difficile ( @-@ @ g/mL ) . | 9 |
25880933 | results | At @ mg BID , mean ( SD ) faecal concentrations of @,@ ( @ ) g/g and @,@ ( @ ) g/g were determined on days @ and @ of dosing respectively . | 10 |
25880933 | results | No notable metabolites were detected in faeces . | 11 |
25880933 | results | Overall , all doses of SMT@ were well tolerated both as single oral doses or BID oral doses for @ days . | 12 |
25880933 | results | The majority ( @ % ) of adverse events ( AEs ) were classified as gastrointestinal disorders and were mild in severity , resolving without treatment . | 13 |
25880933 | results | The gut microbiota was analysed in the multiple dose groups with minimal changes observed in the bacterial groups analysed except for total clostridia which were reduced to below the limit of detection by day @ of dosing . | 14 |
25880933 | conclusions | Oral administration of SMT@ was considered safe and well tolerated and was associated with negligible plasma concentrations after single and multiple doses . | 15 |
25880933 | conclusions | In addition , minimal disruption of normal gut microbiota was noted , confirming the highly selective spectrum of the compound . | 16 |
25880933 | conclusions | These results support the further clinical development of SMT@ as an oral therapy for CDI . | 17 |
25231496 | background | While overall survival for most common cancers in Australia is improving , the rural-urban differential has been widening , with significant excess deaths due to lung , colorectal , breast and prostate cancer in regional Australia . | 0 |
25231496 | background | Internationally a major focus on understanding variations in cancer outcomes has been later presentation to healthcare and later diagnosis . | 1 |
25231496 | background | Approaches to reducing time to diagnosis of symptomatic cancer include public symptom awareness campaigns and interventions in primary care to improve early cancer detection . | 2 |
25231496 | background | This paper reports the protocol of a factorial cluster-randomised trial of community and general practice ( GP ) level interventions to reduce the time to diagnosis of cancer in rural Western Australia ( WA ) . | 3 |
25231496 | methods | The community intervention is a symptom awareness campaign tailored for rural Australians delivered through a community engagement model . | 4 |
25231496 | methods | The GP intervention includes a resource card with symptom risk assessment charts and local referral pathways implemented through multiple academic detailing visits and case studies . | 5 |
25231496 | methods | Participants are eligible if recently diagnosed with breast , colorectal , lung or prostate cancer who reside in specific regions of rural WA with a planned sample size of @ . | 6 |
25231496 | methods | The primary outcome is the Total Diagnostic Interval , defined as the duration from first symptom ( or date of cancer screening test ) to cancer diagnosis . | 7 |
25231496 | methods | Secondary outcomes include cancer stage , healthcare utilisation , disease-free status , survival at @ and @years and cost-effectiveness . | 8 |
25231496 | background | Ethics approval has been granted by the University of Western Australia and from all relevant hospital recruitment sites in WA . | 9 |
25231496 | results | Results of this trial will be reported in peer-reviewed publications and in conference presentations . | 10 |
26024687 | background | This study aimed to evaluate whether incidental CT findings of emphysema , airway thickening and bronchiectasis , as seen on CT scans performed for other non-pulmonary clinical indications , are associated with future acute exacerbations of COPD resulting in hospitalisation or death . | 0 |
26024687 | methods | This multicentre prospective case-cohort study comprised @ subjects who underwent routine diagnostic chest CT for non-pulmonary indications . | 1 |
26024687 | methods | Using a case-cohort approach , we visually graded CT scans from cases and a random sample of @ % of the baseline cohort ( n = @ ) for emphysema severity ( range @-@ ) , airway thickening ( range @-@ ) and bronchiectasis ( range @-@ ) . | 2 |
26024687 | methods | We used weighted Cox proportional hazards analysis to assess the independent association between CT findings and hospitalisation or death due to COPD exacerbation . | 3 |
26024687 | results | During a median follow-up of @ years ( maximum @ years ) , @ COPD events were identified . | 4 |
26024687 | results | The risk of experiencing a future acute exacerbation of COPD resulting in hospitalisation or death was significantly increased in subjects with severe emphysema ( score @ ) and severe airway thickening ( score @ ) . | 5 |
26024687 | results | The respective HRs were @ ( @ % CI @ to @ ) and @ ( @ % CI @ to @ ) . | 6 |
26024687 | results | Severe bronchiectasis ( score @ ) was not significantly associated with increased risk of adverse events ( HR @ ; @ % CI @ to @ ) . | 7 |
26024687 | conclusions | Morphological correlates of COPD such as emphysema and airway thickening detected on CT scans obtained for other non-pulmonary indications are strong independent predictors of subsequent development of acute exacerbations of COPD resulting in hospitalisation or death . | 8 |
24851690 | objective | To explore the feasibility of making a preoperative diagnosis of lung adenocarcinoma shown as ground-glass nodule ( GGN ) on computed tomography ( CT ) . | 0 |
24851690 | methods | A total of @ GGN lesions proved pathologically were divided randomly into A and B groups . | 1 |
24851690 | methods | Then each group was further divided pathologically into preinvasive lesion , minimal invasive adenocarcinoma ( MIA ) and invasive adenocarcinoma ( IAC ) subgroups . | 2 |
24851690 | methods | Group A ( n = @ ) , size of lesion , proportion of ground glass opacity ( GGO ) composition of lesion , long diameter , longest diameter and size of solid component in lesion were measured on CT so as to establish the CT diagnostic standard of lung adenocarcinoma shown as GGN on CT. . | 3 |
24851690 | methods | Group B ( n = @ ) was employed to evaluate the accuracy of the above CT diagnostic standard . | 4 |
24851690 | methods | SPSS @ software was used for statistical analysis . | 5 |
24851690 | results | Significant statistic significance existed in all parameters among all groups ( P < @ ) . | 6 |
24851690 | results | All parameters were correlated the pathologic type of lesion . | 7 |
24851690 | results | The differences were statistically significant ( P = @ ) . | 8 |
24851690 | results | Through the receiver operating characteristic ( ROC ) curve , between groups of preinvasive lesion and MIA , each parameter had a medium diagnostic value of @-@ @ ; between groups of MIA and IAC , size of lesion and long diameter of solid component in lesion had a medium diagnostic value of @-@ @ , longest diameter of solid component , size of solid component in lesion and proportion of GGO composition of lesion had a high diagnostic value with an AUC of > @ . | 9 |
24851690 | results | The CT diagnostic standard , derived from group A , was used to analyze the pathologic type of group B. And t no significant statistic significance existed between CT preoperative diagnosis and operative pathologic diagnosis ( P > @ ) . | 10 |
24851690 | results | The correct diagnosis rates of size of lesion , proportion of GGO composition of lesion , long diameter , longest diameter and size of solid component in lesion were @ % , @ % , @ % , @ % and @ % respectively . | 11 |
24851690 | conclusions | Based upon size of lesion , proportion of GGO composition of lesion , long diameter , longest diameter and size of solid component in lesion , preoperative CT examination may be used to determine the pathological types of lung adenocarcinoma shown as GGN . | 12 |
25883103 | objective | Tonsillectomy surgery is associated with severe postoperative pain that usually requires analgesics including opioids . | 0 |
25883103 | objective | Pain control is still a big problem after tonsillectomy surgery . | 1 |
25883103 | objective | We aimed to evaluate the efficacy of preemptive analgesia using montelukast for pediatric post-tonsillectomy pain management . | 2 |
25883103 | objective | This is the first-time use of montelukast in post-tonsillectomy pain . | 3 |
25883103 | methods | Double-blind , controlled-randomized study . | 4 |
25883103 | methods | University teaching and research hospital . | 5 |
25883103 | methods | A total of @ children , aged @ to @ years , American Society of Anesthesiologist class I-II , scheduled for elective tonsillectomy were enrolled in this clinical trial study . | 6 |
25883103 | methods | The patients were randomized into @ groups : the montelukast group ( group M , n = @ ) and control group ( group C , n = @ ) . | 7 |
25883103 | methods | Group M recieved an oral montelukast tablet and group C recieved placebo at @pm on the morning before surgery . | 8 |
25883103 | methods | Post-tonsillectomy pain was evaluated with the Wong-Baker FACES Scale during the @ hours after surgery . | 9 |
25883103 | methods | Patients ' intraoperative hemodynamic parameters and intraoperative and postoperative complications were recorded . | 10 |
25883103 | results | There were statistically significant differences between group C and group M for Wong-Baker FACES pain rating scale scores ( P < @ ) . | 11 |
25883103 | results | In the @ hours after surgery , the total number of patients using rescue analgesics was higher in group C than in group M , and the difference was statistically significant ( P < @ ) . | 12 |