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24990004 | conclusions | Medical education should emphasize the need for physical medicine and rehabilitative care among individuals with MS , the ability of physiatrists to improve the functional status and quality of life for MS patients , and the team-based nature of MS care . | 7 |
25761501 | background | Lysine requirements of well-nourished children from developing regions have been found to be similar to those of children from developed regions ( @ mgkgd ) . | 0 |
25761501 | background | However , intestinal parasites have been shown to increase lysine requirements in undernourished adults , and it is not known if a similar phenomenon occurs in undernourished children from poor and unsanitary environments . | 1 |
25761501 | objective | Our objective was to measure the lysine requirement of moderately undernourished school-aged Indian children by the indicator amino acid oxidation technique before and after successful treatment for intestinal parasites . | 2 |
25761501 | methods | Twenty-one undernourished school-aged children ( @ y of age ) with z scores between -@ SD and -@ SD for height-for-age or weight-for-age , who tested positive for intestinal parasites , were studied before and after successful antiparasite treatment . | 3 |
25761501 | methods | Children were fed any @ of @ levels of lysine intakes ( @ , @ , @ , @ , @ , @ , and @ mgkgd ) in random order . | 4 |
25761501 | methods | The lysine requirement was determined by applying a @-phase linear regression crossover analysis on the fractional oxidation rate of the tracer L - -LSB- @-C -RSB- phenylalanine in response to the graded lysine intakes . | 5 |
25761501 | results | The lysine requirement of undernourished children with intestinal parasite infestations was determined to be @ mgkgd ( @ % CI : @ , @ mgkgd ) , and after successful antiparasitic treatment it was determined to be @ mgkgd ( @ % CI : @ , @ mgkgd ) . | 6 |
25761501 | results | The results were significantly different ( P < @ ) , although the @ % CIs overlapped . | 7 |
25761501 | conclusions | The lysine requirement in undernourished children is similar to that of well-nourished children , and intestinal parasitic infestation increased the lysine requirement by @ % . | 8 |
24259978 | objective | To compare the efficacy and side effects of low-dose amitriptyline ( AMT ) with proton pump inhibitor treatment in patients with globus pharyngeus . | 0 |
24259978 | methods | Thirty-four patients who fulfilled the Rome III criteria for functional esophageal disorders were included in this study . | 1 |
24259978 | methods | Patients were randomly assigned to receive either @ mg AMT before bedtime ( AMT group ) or @ mg Pantoprazole once daily for @ wk ( conventional group ) . | 2 |
24259978 | methods | The main efficacy endpoint was assessed using the Glasgow Edinburgh Throat Scale ( GETS ) . | 3 |
24259978 | methods | The secondary efficacy endpoints included the Medical Outcomes Study @-item short form health survey -LSB- social functioning ( SF ) -@ -RSB- and the Pittsburgh Sleep Quality Index . | 4 |
24259978 | methods | Treatment response was defined as a > @ % reduction in GETS scores . | 5 |
24259978 | methods | All patients entering this study recorded side effects at days @ , @ , @ , @ and @ using a visual analogue scale . | 6 |
24259978 | results | Thirty patients completed the study . | 7 |
24259978 | results | After @ wk of treatment , the AMT group had a greater response than the conventional group ( @ % vs @ % , P = @ ) . | 8 |
24259978 | results | At day @ , the AMT group showed significantly more improvement than the Conventional group in GETS score ( @ @ vs @ @ , P = @ ) . | 9 |
24259978 | results | After @ wk of treatment , the AMT group showed significantly greater improvement in GETS score and sleep quality than the Conventional group ( @ @ vs @ @ , @ @ vs @ @ ; P < @ for both ) . | 10 |
24259978 | results | Additionally , the AMT group was more likely than the Conventional group to experience improvement in the SF-@ , including general health , vitality , social functioning and mental health ( P = @ , @ , @ and @ ) . | 11 |
24259978 | results | Dry mouth , sleepiness , dizziness and constipation were the most common side effects . | 12 |
24259978 | conclusions | Low-dose AMT is well tolerated and can significantly improve patient symptoms , sleep and quality of life . | 13 |
24259978 | conclusions | Thus , low-dose AMT may be an effective treatment for globus pharyngeus . | 14 |
25817373 | background | Up to now , all tested Ebola virus vaccines have been based on the virus strain from the Zaire outbreak in @ . | 0 |
25817373 | background | We aimed to assess the safety and immunogenicity of a novel recombinant adenovirus type-@ vector-based Ebola vaccine expressing the glycoprotein of the @ epidemic strain . | 1 |
25817373 | methods | We did this randomised , double-blind , placebo-controlled , phase @ clinical trial at one site in Taizhou County , Jiangsu Province , China . | 2 |
25817373 | methods | Healthy adults ( aged @-@ years ) were sequentially enrolled and randomly assigned ( @:@ ) , by computer-generated block randomisation ( block size of six ) , to receive placebo , low-dose adenovirus type-@ vector-based Ebola vaccine , or high-dose vaccine . | 3 |
25817373 | methods | Randomisation was pre-stratified by dose group . | 4 |
25817373 | methods | All participants , investigators , and laboratory staff were masked to treatment allocation . | 5 |
25817373 | methods | The primary safety endpoint was occurrence of solicited adverse reactions within @ days of vaccination . | 6 |
25817373 | methods | The primary immunogenicity endpoints were glycoprotein-specific antibody titres and T-cell responses at day @ after the vaccination . | 7 |
25817373 | methods | Analysis was by intention to treat . | 8 |
25817373 | methods | The study is registered with ClinicalTrials.gov , number NCT@ . | 9 |
25817373 | results | Between Dec @ , @ , and Jan @ , @ , @ participants were enrolled and randomly assigned to receive placebo ( n = @ ) , low-dose vaccine ( n = @ ) , or high-dose vaccine . | 10 |
25817373 | results | Participants were followed up for @ days . | 11 |
25817373 | results | Overall , @ ( @ % ) participants reported at least one solicited adverse reaction within @ days of vaccination ( n = @ in the placebo group vs n = @ in the low-dose group vs n = @ in the high-dose group ; p = @ ) . | 12 |
25817373 | results | The most common reaction was mild pain at the injection site , which was reported in eight ( @ % ) participants in the placebo group , @ ( @ % ) participants in the low-dose group , and @ ( @ % ) participants in the high-dose vaccine group ( p < @ ) . | 13 |
25817373 | results | We recorded no statistical differences in other adverse reactions and laboratory tests across groups . | 14 |
25817373 | results | Glycoprotein-specific antibody titres were significantly increased in participants in the low-dose and high-dose vaccine groups at both day @ ( geometric mean titre @ -LSB- @ % CI @-@ -RSB- and @ -LSB- @-@ -RSB- , respectively ; p < @ ) and day @ ( @ -LSB- @-@ -RSB- and @ -LSB- @-@ -RSB- , respectively ; p < @ ) . | 15 |
25817373 | results | T-cell responses peaked at day @ at a median of @ spot-forming cells ( IQR @-@ ) in participants in the low-dose group and @ cells ( @-@ ) in those in the high-dose group . | 16 |
25817373 | results | @ ( @ % ) participants had mild fever ( n = @ in the placebo group , n = @ in the low-dose group , and n = @ in the high-dose group ) . | 17 |
25817373 | results | No serious adverse events were recorded . | 18 |
25817373 | conclusions | Our findings show that the high-dose vaccine is safe and robustly immunogenic . | 19 |
25817373 | conclusions | One shot of the high-dose vaccine could mount glycoprotein-specific humoral and T-cell response against Ebola virus in @ days . | 20 |
25061700 | objective | To evaluate the thermal antinociceptive effects and duration of action of buprenorphine hydrochloride after IM administration to American kestrels ( Falco sparverius ) . | 0 |
25061700 | methods | @ healthy @-year-old American kestrels . | 1 |
25061700 | methods | Buprenorphine hydrochloride ( @ , @ , and @ mg/kg ) and a control treatment ( saline -LSB- @ % NaCl -RSB- solution ) were administered IM in a randomized crossover experimental design . | 2 |
25061700 | methods | Foot withdrawal response to a thermal stimulus was determined @ hour before ( baseline ) and @ , @ , and @ hours after treatment administration . | 3 |
25061700 | methods | Agitation-sedation scores were determined @ to @ minutes before each thermal stimulus . | 4 |
25061700 | methods | Adverse effects were monitored for @ hours after treatment administration . | 5 |
25061700 | results | Buprenorphine hydrochloride at @ , @ , and @ mg/kg , IM , increased thermal threshold for @ hours , compared with the response for the control treatment . | 6 |
25061700 | results | There were no significant differences among buprenorphine treatments . | 7 |
25061700 | results | A mild sedative effect was detected at a dose of @ mg of buprenorphine/kg . | 8 |
25061700 | conclusions | At the doses tested , buprenorphine hydrochloride resulted in thermal antinociception in American kestrels for at least @ hours , which suggested that buprenorphine has analgesic effects in this species . | 9 |
25061700 | conclusions | Further studies with longer evaluation periods and additional forms of noxious stimuli , formulations , dosages , and routes of administration are needed to fully evaluate the analgesic effects of buprenorphine in American kestrels . | 10 |
24884455 | background | Patellofemoral pain syndrome ( PFPS ) is a common musculoskeletal condition , particularly among women . | 0 |
24884455 | background | Patients with PFPS usually experience weakness in the gluteal muscles , as well as pain and impaired motor control during activities of daily living . | 1 |
24884455 | background | Strengthening the hip muscles is an effective way of treating this disorder . | 2 |
24884455 | background | Neuromuscular training has also been identified as a therapeutic tool , although the benefits of this intervention in patients with PFPS patients remain inconclusive . | 3 |
24884455 | methods | This is a protocol of randomized controlled trial with a blind assessor . | 4 |
24884455 | methods | Thirty-four women with a clinical diagnosis of PFPS participated . | 5 |
24884455 | methods | These participants were allocated into two groups ( experimental and control ) . | 6 |
24884455 | methods | The experimental group performed twelve sessions to strengthen the knee extensors , hip abductor and lateral rotator muscles in association with neuromuscular training of the trunk and lower extremities . | 7 |
24884455 | methods | The control group performed the same number of sessions to strengthen the muscles of the hip and knee . | 8 |
24884455 | methods | The primary outcome was functional capacity ( Anterior Knee Pain Scale - AKPS ) at @weeks . | 9 |
24884455 | methods | Pain intensity , muscle strength and kinematic changes were also measured during the step down test after four weeks of intervention . | 10 |
24884455 | methods | Follow up assessments were conducted after three and six months to assess functional capacity and pain . | 11 |
24884455 | methods | The effects of the treatment ( i.e. between-group differences ) were calculated using mixed linear models . | 12 |
24884455 | conclusions | The present study was initiated on the @st of April @ and is currently in progress . | 13 |
24884455 | conclusions | The results of this study may introduce another effective technique of conservative treatment and could guide physical therapists in the clinical decision-making process for women with PFPS . | 14 |
24738317 | objective | The objective of this study was to evaluate the effect of nasal packing , septal suture technique and vacuum sealing drainage ( VSD ) after septoplasty . | 0 |
24738317 | methods | Ninety patients of nasal septal deviation in Combination with outfracture of the inferior turbinates who had received septoplasty were selected in this study . | 1 |
24738317 | methods | The patients were allocated into three groups , with thirty in each : for packing group , marcel materials were used for nasal packing after septoplasty ; for suturing group , septal suture technique was performed after septoplasty ; for VSD group , one drainage tube was used for negative pressure sucking after septoplasty without nasal packing . | 2 |
24738317 | methods | Postoperative signs and symptoms were compared between three groups . | 3 |
24738317 | methods | The comfort degree assessment included headache and nasal obstruction were evaluated by using visual analogue scale ( VAS ) at the @th hour and @ hour after operation . | 4 |
24738317 | methods | The edema in nasal cavity , hemorrhage . | 5 |
24738317 | methods | abscess , adhesive and healing rates after operation were compared among three groups . | 6 |
24738317 | results | The VAS score of headache and nasal obstruction and the severity of patient 's conditions were significantly less in septal suture group and VSD group than that in packing group at the @th and @th hour after operation . | 7 |
24738317 | results | The mucosa edema of nasal cavity was significantly slighter in septal suture group and VSD group than that in packing group at the third day after operation . | 8 |
24738317 | results | The healing rates and number of complications are better in septal suture group and VSD group than those in packing group at the @th day after operation . | 9 |
24738317 | results | There were no hemorrhage or abscess in VSD group . | 10 |
24738317 | conclusions | Septal suture technique and VSD after septoplasty can significantly relieve the distress of patients and reduce the healing time of mucosa in nasal cavity without increasing the risk of complications . | 11 |
25870079 | objective | To investigate baseline predictors of month @ best-corrected visual acuity ( BCVA ) and central foveal thickness ( CFT ) in patients with diabetic macular edema ( DME ) treated monthly with ranibizumab or sham . | 0 |
25870079 | methods | Post hoc analysis of DME patients in @ identical phase @ studies . | 1 |
25870079 | methods | Patients randomized to ranibizumab ( n = @ ) or sham ( n = @ ) . | 2 |
25870079 | methods | Multivariate regression on predictors with P < @ in univariate logistic regression using backward selection to retain predictors with P < @ . | 3 |
25870079 | methods | Patient characteristics correlating with month @ BCVA in Early Treatment Diabetic Retinopathy Study letter score @ ( @/@ ) or @ ( @/@ ) , gain or loss from baseline BCVA of @ , or CFT @ m. | 4 |
25870079 | results | Baseline predictors of BCVA @/@ in ranibizumab-treated patients were good BCVA , submacular fluid , no cardiovascular disease , no scatter photocoagulation , and male gender , whereas in sham-treated patients , they were mild increase in CFT , presence of hard exudates in center subfield , and absence of renal disease . | 5 |
25870079 | results | Predictors of improvement in BCVA letter score @ in ranibizumab-treated patients were poor BCVA , submacular fluid , young age , and short diabetes duration , and those in sham-treated patients were poor BCVA , young age , and mild increase in CFT . | 6 |
25870079 | results | Predictors of resolution of edema ( CFT @ m ) in ranibizumab-treated patients were mild foveal thickening and prominent subfoveal fluid , and those in sham-treated patients were poor BCVA , mild foveal thickening , and statin usage . | 7 |
25870079 | results | Month @ BCVA @/@ was predicted by poor baseline BCVA in ranibizumab-treated patients , and by poor baseline BCVA , large intraretinal cystoid spaces , renal disease , and absence of hypercholesterolemia in sham-treated patients . | 8 |
25870079 | results | Loss of BCVA @ letters was predicted in sham-treated patients by submacular fluid , intraretinal cystoid spaces , and renal disease . | 9 |
25870079 | conclusions | Patients with DME and submacular fluid , intraretinal cysts , severe thickening , or renal disease respond poorly when untreated and respond well to ranibizumab treatment . | 10 |
25870079 | conclusions | Elimination of submacular fluid , intraretinal cysts , and severe thickening are important goals of DME treatment , and in patients with renal disease , treatment should be very aggressive , with a goal of eliminating all macular fluid . | 11 |
24488743 | objective | This study included @-month-old children with a history of institutional care . | 0 |
24488743 | objective | Our goal was to : ( @ ) examine differences in indiscriminate social behaviors in children with a history of institutional care compared with home-reared children ; ( @ ) test whether foster care reduces indiscriminate social behaviors in a randomized controlled trial ; and ( @ ) examine early predictors of indiscriminate behaviors . | 1 |
24488743 | methods | Participants were @ children with a history of institutional care and @ never-institutionalized control ( NIG ) subjects enrolled in a randomized controlled trial of foster care for institutional care , assessed from toddlerhood to @ months . | 2 |
24488743 | methods | Indiscriminate social behaviors were measured naturalistically by using the Stranger at the Door procedure . | 3 |