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24488743 | results | In the Stranger at the Door procedure , children with a history of institutional care left with a stranger at higher rates than NIG subjects ( @ % vs. @ % ; P < @ ) . | 4 |
24488743 | results | Children in the care as usual group left more than NIG subjects ( @ % vs. @ % ; P @ ) . | 5 |
24488743 | results | The differences between the foster care group ( @ % ) and the care as usual group and between foster care group and NIG were not significant . | 6 |
24488743 | results | In a logistic regression , early disorganized attachment behaviors , baseline developmental quotient , and caregiving quality after randomization contributed to variance at @ months . | 7 |
24488743 | results | In the same analysis using only children with a history of institutional care , only disorganized attachment contributed significantly to @-month indiscriminate social behaviors ( Exp -LSB- B -RSB- = @ -LSB- @ % confidence interval : @-@ @ -RSB- ) . | 8 |
24488743 | conclusions | Observed socially indiscriminate behaviors at @ months were associated with prolonged exposure to institutional care . | 9 |
24488743 | conclusions | Young children raised in conditions of deprivation who fail to develop organized attachments as toddlers are at increased risk for subsequent indiscriminate behaviors . | 10 |
25840499 | background | One goal of guideline-based asthma therapy is minimal use of short-acting agonist ( SABA ) medications . | 0 |
25840499 | background | Inner-city children with asthma are known to have high SABA use . | 1 |
25840499 | objective | To examine factors associated with high SABA use in inner-city children with asthma . | 2 |
25840499 | methods | One hundred inner-city children with persistent asthma were enrolled into a randomized controlled trial of an emergency department ( ED ) and home intervention . | 3 |
25840499 | methods | All children underwent serologic allergen specific IgE and salivary cotinine testing at the ED enrollment visit . | 4 |
25840499 | methods | Pharmacy records for the past @ months were obtained . | 5 |
25840499 | methods | Number of SABA fills during the past @ months was categorized into low - to moderate - vs high-use groups . | 6 |
25840499 | methods | SABA groups were compared by the number of symptom days and nights , allergen sensitization , and exposures . | 7 |
25840499 | methods | Regression models were used to predict high SABA use . | 8 |
25840499 | results | Mean number of SABA fills over @ months was @ . | 9 |
25840499 | results | Unadjusted bivariate analysis showed that high SABA users were more than @ times more likely to have an asthma hospitalization , almost @ times more likely to have an asthma intensive care unit admission , and more than @ times more likely to have prior specialty asthma care or positive cockroach sensitization than low to moderate SABA users . | 10 |
25840499 | results | In the final regression model , for every additional inhaled corticosteroid fill , a child was @ times more likely and a child with positive cockroach sensitization was almost @ times more likely to have high SABA use when controlling for prior intensive care unit admission , receipt of specialty care , child age , and income . | 11 |
25840499 | conclusions | Providers should closely monitor SABA and controller medication use , allergen sensitization , and exposures in children with persistent asthma . | 12 |
24674053 | objective | To compare the cardiopulmonary effects of intravenous ( IV ) and intramuscular ( IM ) medetomidine and butorphanol with or without MK-@ . | 0 |
24674053 | methods | Prospective , randomized experimental cross-over . | 1 |
24674053 | methods | Eight purpose-bred beagles ( two females , six males ) , @-@ years old and weighing @ @ kg ( mean SD ) . | 2 |
24674053 | methods | All dogs received four different treatments as follows : medetomidine @ g kg ( -@ ) and butorphanol tartrate @ mg kg ( -@ ) IV and IM ( MB ) , and MB combined with MK-@ ,@ g kg ( -@ ) ( MBMK ) IV and IM . | 3 |
24674053 | methods | Heart rate ( HR ) , arterial blood pressures ( SAP , MAP , DAP ) , central venous pressure ( CVP ) , cardiac output , respiratory rate ( fR ) , rectal temperature ( RT ) were measured and arterial blood samples were obtained for gas analysis at baseline and at @ , @ , @ , @ , @ and @ minutes after drug administration . | 4 |
24674053 | methods | The cardiac index ( CI ) , systemic vascular resistance index ( SVRI ) and oxygen delivery index ( DO@ I ) were calculated . | 5 |
24674053 | methods | After the follow-up period atipamezole @ g kg ( -@ ) IM was given to reverse sedation . | 6 |
24674053 | results | HR , CI and DO@ I were significantly higher with MBMK after both IV and IM administration . | 7 |
24674053 | results | Similarly , SAP , MAP , DAP , CVP , SVRI and RT were significantly lower after MBMK than with MB . | 8 |
24674053 | results | There were no differences in fR between treatments , but arterial partial pressure of oxygen decreased transiently after all treatments . | 9 |
24674053 | results | Recoveries were uneventful following atipamezole administration after all treatments . | 10 |
24674053 | conclusions | MK-@ attenuated the cardiovascular effects of a medetomidine-butorphanol combination after IV and IM administration . | 11 |
25011657 | objective | To evaluate adherence to therapy in acne patients using mobile phones and Short Message Service ( SMS ) to communicate . | 0 |
25011657 | methods | @ patients were randomly assigned to two groups : the SMS group received @ text messages twice a day for a period of @ weeks ; the control group did not receive any messages . | 1 |
25011657 | methods | Before and after @ weeks , the following evaluations were performed in all patients : digital photographs , the Global Acne Grading System , the Dermatology Life Quality Index , the Cardiff Acne Disability Index , the doctor-patient relationship evaluated through the Patient-Doctor Depth-of-Relationship Scale , and the adherence to treatment evaluated by asking patients how many days a week they had followed the therapy . | 2 |
25011657 | methods | For statistical analysis we used Student 's t test . | 3 |
25011657 | results | The SMS group had a better improvement of all parameters compared to the control group . | 4 |
25011657 | conclusions | Adherence and compliance are higher for patients who are included in a strategy of control . | 5 |
24440809 | background | Ondansetron , sometimes combined with acustimulation at PC@ ( Neiguan ) , is commonly used for preventing postoperative nausea and vomiting , but PC@ is not the only point that can be used for this purpose . | 0 |
24440809 | objective | To evaluate the combined effects of ondansetron and ST@ ( Zusanli ) acupuncture point injection on postoperative vomiting ( POV ) after laparoscopic surgery . | 1 |
24440809 | methods | A randomised , patient and assessor-blinded , placebo-controlled clinical study was conducted . | 2 |
24440809 | methods | One hundred and sixty patients undergoing laparoscopic surgery were randomly assigned to one of four groups : ( @ ) group P ( placebo-control ) : intravenous normal saline + bilateral non-acupuncture point injection of vitamin B@ ( n = @ ) ; ( @ ) group O ( ondansetron ) : intravenous ondansetron + bilateral ST@ sham injection ( n = @ ) ; ( @ ) group A ( acupuncture point injection ) : intravenous normal saline + bilateral acupuncture point injection at ST@ of vitamin B@ ( n = @ ) ; ( @ ) group C ( combination ) : intravenous ondansetron + bilateral acupuncture point injection at ST@ of vitamin B@ ( n = @ ) . | 3 |
24440809 | methods | Interventions were made on arrival at the postanaesthesia care unit . | 4 |
24440809 | methods | The primary outcome was the incidence of POV within @ h after the operation . | 5 |
24440809 | methods | Secondary outcomes included severity of vomiting , incidence of rescue treatment , patients ' satisfaction and the first anal exsufflation time @ h after the operation . | 6 |
24440809 | results | The incidence of POV within @ h postoperative period in each group was P @ % ; O @ % , A @ % and C @ % . | 7 |
24440809 | results | Outcomes for all intervention groups were significantly better than that for placebo ( p < @ ) . | 8 |
24440809 | results | For the three interventions compared with placebo , the numbers needed to treat ( NNTs ) were O , NNT = @ ; A , NNT = @ and C , NNT = @ . | 9 |
24440809 | results | The secondary outcomes also demonstrated greater benefits of the combined regimen , with improvement seen in all the measures . | 10 |
24440809 | conclusions | Ondansetron , acupuncture , and ondansetron and acupuncture combined are effective prophylaxis for POV . | 11 |
24601726 | background | The impact of sugar-sweetened beverages ( SSB ) on lipid metabolism when consumed in moderate amounts by normal weight subjects is debated . | 0 |
24601726 | objective | The objective of the study was to investigate the effect of different types of sugars in SSB on fatty acid metabolism ( ie , fatty acid synthesis and oxidation ) in healthy young men . | 1 |
24601726 | methods | Thirty-four normal-weight men were studied in a randomized crossover study . | 2 |
24601726 | methods | Four isocaloric @-week interventions with SSB were performed in random order : medium fructose ( MF ; @ g/d ) ; high fructose ( HF ; @ g/d ) , high sucrose ( HS ; @ g/d ) , and high glucose ( HG ; @g/d ) . | 3 |
24601726 | methods | Fasting total plasma fatty acid composition was measured after each intervention . | 4 |
24601726 | methods | Acylcarnitines were measured in the fasting state and after a euglycemic hyperinsulinemic clamp in nine subjects . | 5 |
24601726 | results | The relative abundance of palmitate ( @:@ ) and the molar fatty acid ratio of palmitate to linoleic acid ( @:@ to@ :@ ) as markers of fatty acid synthesis were increased after HF -LSB- relative abundance of palmitate : @ % @ % ( percentage of total fatty acids by weight SD ) -RSB- and MF ( @ % @ % ) compared with HS ( @ % @ % , P < @ ) , HG ( @ % @ % , P < @ ) , or baseline ( @ % @ % , P < @ ) . | 6 |
24601726 | results | After HS and HG , the relative abundance of palmitate was equal to baseline . | 7 |
24601726 | results | Fasting palmitoylcarnitine was significantly increased after HF and HS ( HF and HS vs. HG : P = @ ) , decreasing after inhibition of lipolysis by insulin in the clamp . | 8 |
24601726 | conclusions | When consumed in moderate amounts , fructose but not sucrose or glucose in SSB increases fatty acid synthesis ( palmitate ) , whereas fasting long-chain acylcarnitines are increased after both fructose and sucrose , indicating an impaired - oxidation flux . | 9 |
25465830 | background | Little is known about global patterns of critical care unit ( CCU ) care and the relationship with outcomes in patients with acute decompensated heart failure ( ADHF ) . | 0 |
25465830 | background | Whether a ward or a CCU admission is associated with better outcomes is unclear . | 1 |
25465830 | methods | Patients in the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure ( ASCEND-HF ) trial were initially hospitalized in a ward or CCU ( coronary or intensive care unit ) . | 2 |
25465830 | methods | Sites were geographically classified : Asia-Pacific ( AP ) , Central Europe ( CE ) , Latin America ( LA ) , North America ( NA ) , and Western-Europe ( WE ) . | 3 |
25465830 | methods | The primary outcome of @-day all-cause mortality or all-cause hospital readmission was adjusted using a two-stage multivariable logistic regression model with a generalized estimated equation that took sites within each country as a nested random factor . | 4 |
25465830 | results | Overall , @ ( @ % ) patients were admitted to a CCU and @ ( @ % ) to a ward , and this varied by region : @ % AP , @ % CE , @ % WE , @ % LA , and @ % NA . | 5 |
25465830 | results | The @-day death or readmission rate was @ % in ward patients and @ % in CCU patients ( risk-adjusted Odds Ratio -LSB- OR -RSB- @ : @ % CI , @-@ @ ) . | 6 |
25465830 | results | Compared with CCU patients in NA ( @ % @-day event rate ) , the primary outcomes were : AP ( @ % , Odds Ratio -LSB- OR -RSB- @ ; @ % confidence Interval -LSB- CI -RSB- , @ to @ ) , CE ( @ % , OR @ : @ % CI , @ to @ ) , LA ( @ % , OR @ : @ % CI , @ to @ ) , and WE ( @ % , OR @ , @ % CI , @ to @ ) . | 7 |
25465830 | results | No regional differences in @-day mortality were observed ; however , @-day readmission rates were highest in NA sites . | 8 |
25465830 | conclusions | Management of patients with ADHF varies significantly , and after adjustment , CCU care was associated with higher risk of early mortality , not explained by international differences . | 9 |
25465830 | conclusions | These findings may help to improve the early decisions regarding risk stratification of patients hospitalized with ADHF . | 10 |
26124485 | objective | Hand-foot syndrome ( HFS ) is a frequently occurring adverse event associated with anticancer drugs . | 0 |
26124485 | objective | This study compares a newly introduced ointment containing several antioxidants and exhibiting high radical protection factor , which has been available on the German market since @ , with urea cream for prevention of HFS in patients treated with capecitabine . | 1 |
26124485 | methods | Patients with GI tumors or breast cancer treated with capecitabine were included in this randomized phase III study . | 2 |
26124485 | methods | The primary end point was prevention of HFS of any grade within @ weeks of treatment as indicated by a standardized patient diary . | 3 |
26124485 | methods | The study had @ % power to show a @ % reduction of the incidence of HFS with the new ointment . | 4 |
26124485 | methods | Secondary end points included time to development of HFS greater than grade @ , evaluation of capecitabine dose intensity , and quality of life analyses . | 5 |
26124485 | results | A total of @ patients were evaluable . | 6 |
26124485 | results | In total , @ of @ patients experienced HFS ( @ % ) , @ % with the new ointment and @ % in the urea arm ( stratified odds ratio , @ ; P = @ ) . | 7 |
26124485 | results | Time to HFS greater than grade @ was comparable , but time to any-grade HFS was significantly longer in the urea group ( P = @ ) . | 8 |
26124485 | results | Capecitabine dose intensity , time under study , and percentage of days with correct administration of study medication were identical , as were adverse events except for HFS . | 9 |
26124485 | results | Skin-related quality of life was significantly worse in the group treated with the new ointment at the end of study treatment . | 10 |
26124485 | conclusions | This trial demonstrated that @ % urea cream was superior to the new ointment at preventing HFS over the first @ weeks of treatment with capecitabine . | 11 |
25225241 | background | Atrial fibrillation ( AFib ) is common in heart failure ( HF ) with preserved ejection fraction ( HFpEF ) . | 0 |
25225241 | background | Current AFib stroke risk prediction models include the presence of HF but do not specifically include HFpEF as a risk factor . | 1 |
25225241 | background | Whether a history of AFib should be used to identify patients with HFpEF who are at risk has not been established . | 2 |
25225241 | results | Baseline characteristics and outcomes of patients with HFpEF in the Irbesartan in Heart Failure with Preserved Ejection Fraction Trial were analyzed in relation to AFib . | 3 |
25225241 | results | At baseline , @ ( @ % ) had a history of AFib . | 4 |
25225241 | results | Of these @ ( @ % ) had history of AFib alone , whereas @ ( @ % ) had both a history and AFib on ECG ; @ ( @ % ) had neither . | 5 |
25225241 | results | There were no significant differences in the risk of stroke between the @ groups with a history of AFib who did or did not have AFib present on baseline ECG . | 6 |
25225241 | results | During a median follow-up of @ months , a fatal or nonfatal stroke occurred in @ % ( @/@ ) patients with history of AFib compared with @ % ( @/@ ) with no AFib . | 7 |
25225241 | results | Having a history of AFib was independently associated with higher risk of stroke ( hazard ratio , @ ; @ % confidence interval , @-@ @ ; P < @ ) compared with those with no history of AFib . | 8 |
25225241 | conclusions | In patients with HFpEF , a history of AFib was common and independently associated with increased risk of stroke , regardless of whether AFib was present on ECG . | 9 |
25225241 | conclusions | Patients with HFpEF and a history of AFib should be considered at risk . | 10 |
25225241 | conclusions | Further studies are needed to determine whether this risk can be safely reduced . | 11 |
25637376 | background | Selective kappa opioid receptor antagonism is a promising experimental strategy for the treatment of depression . | 0 |
25637376 | background | The kappa opioid receptor antagonist , LY@ , exhibits ~ @-fold higher affinity for kappa opioid receptors over mu opioid receptors , which is the next closest identified pharmacology . | 1 |
25637376 | methods | Here , we determined kappa opioid receptor pharmacological selectivity of LY@ by assessing mu opioid receptor antagonism using translational pupillometry in rats and humans . | 2 |
25637376 | results | In rats , morphine-induced mydriasis was completely blocked by the nonselective opioid receptor antagonist naloxone ( @mg/kg , which produced @ % mu opioid receptor occupancy ) , while @ and @ mg/kg LY@ ( which produced @ % and @ % mu opioid receptor occupancy , respectively ) only partially blocked morphine-induced mydriasis . | 3 |
25637376 | results | In humans , fentanyl-induced miosis was completely blocked by @mg naltrexone , and LY@ dose-dependently blocked miosis at @ and @ mg ( minimal-to-no blockade at @-@mg ) . | 4 |