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24967410 | objective | Noncardiac chest pain ( NCCP ) is seen more frequently in young population and in these patients loss of function is evolving in social and professional areas . | 0 |
24967410 | objective | The aim of the study is to evaluate the levels of anxiety and somatic perception in patients with chest pain presenting to cardiology clinic . | 1 |
24967410 | methods | Fifty-one patients with noncardiac chest pain and @ healthy controls were included in the study . | 2 |
24967410 | methods | All participants performed self-report based health anxiety inventory ( HAI ) , somatosensory amplification scale ( SAS ) , and Toronto alexithymia scale ( TAS ) . | 3 |
24967410 | results | The patient group had significantly higher scores on the SAS , HAI-@ , and HAI-T scales compared to controls ( P < @ , P = @ , and P = @ , resp . ) | 4 |
24967410 | results | SAS , HAI-@ , and HAI-T scores were significantly higher in female patients than male ( P = @ , @ , and @ , resp . ) | 5 |
24967410 | results | There were significant differences in all TAS subscale scores between two groups . | 6 |
24967410 | results | Patients , who had total TAS score more than @ , also presented higher levels of health anxiety ( P = @ ) . | 7 |
24967410 | conclusions | Anxiety , somatic symptoms , and the exaggerated sense of bodily sensations are common in patients with NCCP . | 8 |
24967410 | conclusions | These patients unnecessarily occupy the cardiology outpatient clinics . | 9 |
24967410 | conclusions | These negative results can be eliminated when consultation-liaison psychiatry evaluates these patients in collaboration with cardiology departments . | 10 |
25876339 | objective | To compare the differences in the clinical efficacy on Alzheimer 's disease between acupuncture and medicine . | 0 |
25876339 | methods | One hundred and forty-one patients were randomized into an acupuncture group ( @ cases ) and a medicine group ( @ cases ) . | 1 |
25876339 | methods | In the acupuncture group , the needling technique for benefiting qi , promoting blood circulation , regulating mind and improving intelligence was used at Shenting ( GV @ ) , Baihui ( GV @ ) , Fengchi ( GB @ ) , Wangu ( GB @ ) , Danzhong ( CV @ ) , Zhangwan ( CV @ ) , Qihai ( CV @ ) , Xuehai ( SP @ ) and Zusanli ( ST @ ) . | 2 |
25876339 | methods | The supplementary acupoints were selected according to the symptoms and physical signs . | 3 |
25876339 | methods | Acupuncture was given once a day and @ treatments were required for a week . | 4 |
25876339 | methods | In the medicine group , the choline sterase inhibitor , donepezil ( aricept ) was prescribed for oral administration , @ tablet ( @ mg ) each time , once every night . | 5 |
25876339 | methods | Four weeks later , the dose was increased to @ tablets ( @ mg ) each time . | 6 |
25876339 | methods | In the two groups , the treatment of @ weeks made one session and @ sessions were required . | 7 |
25876339 | methods | The changes of scores before and after treatment in the minimum mental state examination ( MMSE ) , the activity of daily living scale ( ADL ) , Alzheimer 's disease assessment scale-cognition ( ADAS-cog ) and the digit span ( DS ) were observed . | 8 |
25876339 | results | After treatment , scores of MMSE and DS were increased as compared with those before treatment ( both P < @ ) and scores of ADL and ADAS-cog were reduced as compared with those before treatment . | 9 |
25876339 | results | The score differences in MMSE , ADL , ADAS-cog and DS before and after treatment were significant in the two groups ( all P < @ ) . | 10 |
25876339 | conclusions | The needling technique for benefiting qi , promoting blood circulation , regulating mind and improving intelligence significantly improves the overall function , cognition and activity of daily life in the patients of Alzheimer 's disease and the efficacy is better than donepezil . | 11 |
24946799 | objective | There is little evidence available on the use of robot-assisted therapy in subacute stroke patients . | 0 |
24946799 | objective | A randomized controlled trial was carried out to evaluate the short-time efficacy of intensive robot-assisted therapy compared to usual physical therapy performed in the early phase after stroke onset . | 1 |
24946799 | methods | Fifty-three subacute stroke patients at their first-ever stroke were enrolled @days after the acute event and randomized into two groups , both exposed to standard therapy . | 2 |
24946799 | methods | Additional @ sessions of robot-assisted therapy were provided to the Experimental Group . | 3 |
24946799 | methods | Additional @ sessions of usual therapy were provided to the Control Group.The following impairment evaluations were performed at the beginning ( T@ ) , after @ sessions ( T@ ) , and at the end of the treatment ( T@ ) : Fugl-Meyer Assessment Scale ( FM ) , Modified Ashworth Scale-Shoulder ( MAS-S ) , Modified Ashworth Scale-Elbow ( MAS-E ) , Total Passive Range of Motion-Shoulder/Elbow ( pROM ) , and Motricity Index ( MI ) . | 4 |
24946799 | results | Evidence of significant improvements in MAS-S ( p = @ ) , MAS-E ( p = @ ) and pROM ( p < @ ) was found in the Experimental Group . | 5 |
24946799 | results | Significant improvement was demonstrated in both Experimental and Control Group in FM ( EG : p < @ , CG : p < @ ) and MI ( EG : p < @ , CG : p < @ ) , with an higher improvement in the Experimental Group . | 6 |
24946799 | conclusions | Robot-assisted upper limb rehabilitation treatment can contribute to increasing motor recovery in subacute stroke patients . | 7 |
24946799 | conclusions | Focusing on the early phase of stroke recovery has a high potential impact in clinical practice . | 8 |
24668328 | background | In advanced gastric cancer ( AGC ) , no globally accepted prognostic scoring system has been developed . | 0 |
24668328 | background | Therefore , we explored baseline prognostic factors in Japanese AGC patients using the data from a randomized controlled trial , Japan Clinical Oncology Group ( JCOG ) @ , which investigated the efficacy of systemic chemotherapy as a first-line treatment . | 1 |
24668328 | methods | Prognostic factors and prognostic indices for overall survival were screened and evaluated in patients enrolled in JCOG@ using the Cox proportional hazard model . | 2 |
24668328 | methods | The Royal Marsden Hospital prognostic model was also applied to the JCOG@ trial . | 3 |
24668328 | results | A total of @ ( @ % ) of the @ patients randomized in the JCOG@ trial , for whom complete data were available for multivariate analyses , was included in the present study ( @-fluorouracil arm , n = @ ; irinotecan plus cisplatin arm , n = @ ; S-@ arm , n = @ ) . | 4 |
24668328 | results | The median survival time ( MST ) for all patients was @ months . | 5 |
24668328 | results | To construct a prognostic index , we selected four risk factors by multivariate analysis : performance status @ , number of metastatic sites @ , no prior gastrectomy , and elevated alkaline phosphatase . | 6 |
24668328 | results | MSTs were @ months for patients categorized into the low-risk group , who had zero or one risk factor ( n = @ ) ; @ months for patients in the moderate-risk group , who had two or three risk factors ( n = @ ) ; and @ months for patients in the high-risk group , who had all four risk factors ( n = @ ) . | 7 |
24668328 | conclusions | In the present study , we propose a new prognostic index for patients with AGC . | 8 |
24668328 | conclusions | This can be used for more appropriate patient stratification in future clinical trials . | 9 |
24834773 | background | Treatment of food allergy essentially consists of food avoidance , but immunotherapy with food is emerging as a new therapeutic option . | 0 |
24834773 | objective | To evaluate clinical improvement and immunological changes in patients with peach allergy following sublingual immunotherapy ( SLIT ) with a Prup@ quantified peach extract . | 1 |
24834773 | methods | A randomized , double-blind , placebo-controlled clinical trial with peach SLIT was conducted . | 2 |
24834773 | methods | We assessed clinical efficacy after @ months of treatment by means of double-blind , placebo-controlled oral challenges with peach and also evaluated immunological changes ( basophil activation test -LSB- BAT -RSB- and determination of sulphidoleukotriene production ) following stimulation with peach peel and pulp , rPrup@ , rMald @ , and rMal d @ stimulation . | 3 |
24834773 | methods | We also measured specific IgE and IgG@ to Pru p@ . | 4 |
24834773 | results | After @ months of SLIT ( T@ ) , the active group showed a @-fold improvement in tolerance to Prup@ and a significant increase in IgE to rPrup@ and in sLT production following stimulation with peach peel and rPrup@ . | 5 |
24834773 | results | There was also a significant increase in BAT results after stimulation with rPrup@ at @ month of SLIT ( T@ ) . | 6 |
24834773 | results | Statistically significant between-group differences were only observed for BAT with peach peel and pulp at T@ and T@ and for BAT with rPru p@ at T@ . | 7 |
24834773 | results | No changes were observed in BAT with rMal d @ or rMal d @ or in IgG@ levels to nPrup@ . | 8 |
24834773 | conclusions | SLIT with a Pru p @ quantified peach extract is clinically effective and leads to an increase in basophil activation and sulphidoleukotriene production following stimulation with rPru p@ and peach peel in the first months of treatment . | 9 |
24777223 | objective | Pharmacogenetics ( PGx ) promises to optimize patient response to therapy . | 0 |
24777223 | objective | However , the public 's acceptance of PGx is not well known , notably when this applies to children . | 1 |
24777223 | objective | Our objective was to explore perceptions of PGx testing among individuals , who differ from each other by either parental status or educational exposure to PGx , and to explore parents ' views between PGx testing for oneself and PGx testing for their children . | 2 |
24777223 | methods | An exploratory survey was conducted among parents and other adults . | 3 |
24777223 | methods | Surveys P and C were completed by parents , survey NP by middle-aged nonparents , and survey MS by medical students . | 4 |
24777223 | results | Proper explanation before PGx testing appeared to be the most important issue to the respondents ( eg , P = @ @ ( -@ ) for survey NP ) . | 5 |
24777223 | results | Respondents who were more knowledgeable about PGx were also more comfortable with PGx testing ( eg , P = @ @ ( -@ ) in case of mild disease ) . | 6 |
24777223 | results | When PGx testing was for one 's child , parents valued their own understanding more than their child 's assent ( P = @ @ ( -@ ) ) . | 7 |
24777223 | conclusions | The acceptability of PGx testing , either for oneself or for one 's child , seemed to depend on baseline PGx knowledge , but not on parenthood . | 8 |
24320560 | objective | Dilatation and curettage ( D&C ) is a common day-care procedure in obstetrics and gynecology , with patients discharged after a brief hospital stay on the same day of the surgery . | 0 |
24320560 | objective | Although it has a short duration , severe pain occurs during the procedure . | 1 |
24320560 | objective | Therefore , this surgical procedure requires an anesthetic to provide adequate analgesia , rapid onset , and rapid recovery . | 2 |
24320560 | objective | The main objective of the present study was to compare the analgesic effectiveness and safety of tramadol with those of fentanyl during D&C . | 3 |
24320560 | methods | The study comprised @ women with American Society of Anesthesiologists classification I-II who were scheduled for a D&C procedure . | 4 |
24320560 | methods | Baseline anesthesia was maintained with @mg/kg propofol , and the patients were then randomly allocated to receive tramadol @mg/kg ( Group T , n = @ ) or fentanyl @g/kg ( Group F , n = @ ) . | 5 |
24320560 | methods | Hemodynamic variables , sedation , pain , the Aldrete recovery score , and side-effects were recorded . | 6 |
24320560 | results | SpO levels in Group F in the @th min and at the end of the procedure were significantly lower than those in Group T ( P = @ and @ , respectively ) . | 7 |
24320560 | conclusions | Tramadol provides similar analgesic efficacy to fentanyl . | 8 |
24320560 | conclusions | Furthermore , tramadol may provide better respiratory stability in patients undergoing a D&C procedure . | 9 |
26483244 | background | Based on current recommendations , @ + pack-years of smoking are required for eligibility for low-dose CT ( LDCT ) lung cancer screening ; former smokers must have quit within @ years . | 0 |
26483244 | background | We investigated whether current smokers with @ to @ pack-years have similar lung cancer risks as eligible former smokers and also whether they have a different demographic profile . | 1 |
26483244 | methods | The Prostate , Lung , Colorectal , and Ovarian Cancer Screening Trial ( PLCO ) was a randomly assigned screening trial of subjects age @ to @ years with chest radiographs ( CXR ) used for lung cancer . | 2 |
26483244 | methods | Subjects completed a baseline questionnaire containing smoking history questions . | 3 |
26483244 | methods | Cox proportional hazards models , adjusted for age and sex , were utilized to estimate hazard ratios ( HRs ) for various smoking history groups . | 4 |
26483244 | methods | Next , we utilized the National Health Interview Survey ( NHIS ) , which inquired about smoking history and race/ethnicity , to analyze the demographic profiles of various high-risk smoking history categories . | 5 |
26483244 | methods | All statistical tests were two-sided . | 6 |
26483244 | results | The PLCO cohort included @ @ former and @ @ current LDCT-eligible smokers , plus @ @ - to @-pack-year current smokers . | 7 |
26483244 | results | The hazard ratio for @ - to @-pack-year current smokers compared with eligible ( @ + pack-year ) former smokers was @ ( @ % confidence interval -LSB- CI -RSB- = @ to @ ) . | 8 |
26483244 | results | Based on the NHIS , @ million persons in the United States are currently LDCT eligible ; an additional @ million ( @ % , @ % CI = @ % to @ % ) are @ - to @-pack-year current smokers . | 9 |
26483244 | results | The percentage increase in eligibles if @ - to @-pack-year current smokers were included was substantially greater for women than men ( @ % , @ % CI = @ % to @ % ; vs @ % , @ % CI = @ % to @ % , P < @ ) and for minorities than non-Hispanic whites ( @ % , @ % CI = @ % to @ % ; vs @ % , @ % CI = @ % to @ % , P < @ ) . | 10 |
26483244 | conclusions | The potential benefits and harms of recommending LDCT screening for @ to @-pack-year current smokers should be assessed . | 11 |
25624432 | objective | Progression-free survival ( PFS ) in metastatic castration-resistant prostate cancer ( mCRPC ) trials has been inconsistently defined and poorly associated with overall survival ( OS ) . | 0 |
25624432 | objective | A reproducible quantitative definition of radiographic PFS ( rPFS ) was tested for association with a coprimary end point of OS in a randomized trial of abiraterone in patients with mCRPC . | 1 |
25624432 | methods | rPFS was defined as two new lesions on an @-week bone scan plus two additional lesions on a confirmatory scan , two new confirmed lesions on any scan @ weeks after random assignment , and/or progression in nodes or viscera on cross-sectional imaging , or death . | 2 |
25624432 | methods | rPFS was assessed by independent review at @ % of deaths and by investigator review at @ % and @ % of deaths . | 3 |
25624432 | methods | rPFS and OS association was evaluated by Spearman 's correlation . | 4 |
25624432 | results | A total of @,@ patients were randomly assigned to abiraterone plus prednisone or prednisone alone . | 5 |
25624432 | results | At first interim analysis , the hazard ratio ( HR ) by independent review was @ ( @ % CI , @ to @ ; P < @ ; abiraterone plus prednisone : median rPFS , not estimable ; prednisone : median rPFS , @ months ) . | 6 |
25624432 | results | Similar HRs were obtained by investigator review at the first two interim analyses ( HR , @ ; @ % CI , @ to @ ; P < @ and HR , @ ; @ % CI , @ to @ ; P < @ , respectively ) , validating the imaging data assay used . | 7 |
25624432 | results | Spearman 's correlation coefficient between rPFS and OS was @ . | 8 |
25624432 | conclusions | rPFS was highly consistent and highly associated with OS , providing initial prospective evidence on further developing rPFS as an intermediate end point in mCRPC trials . | 9 |
24990004 | background | Rehabilitation care is an important part of comprehensive care for MS patients . | 0 |
24990004 | background | Little is known about the number of physiatry residents who are interested in providing care to individuals with multiple sclerosis -LSB- MS -RSB- . | 1 |
24990004 | objective | This study examines factors that influence physiatry residents ' interest in providing care to MS patients . | 2 |
24990004 | methods | We randomly sampled half of all Accreditation Council for Graduate Medical Education-certified physical medicine and rehabilitation residency programs in the continental United States and Puerto Rico . | 3 |
24990004 | methods | Surveys were received from @ % of programs ( Stage @ response rate ) and from @ residents ( @ % Stage @ response rate ) . | 4 |
24990004 | results | Residents expressing interest in providing MS care were more likely to be female , Asian , and to select statements emphasizing multidisciplinary care approaches and a community of dedicated professional colleagues as positive features of MS patient care . | 5 |
24990004 | results | Residents interested in teaching and with more education debt were marginally more likely to express interest in MS care . | 6 |