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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nevirapine and rifampin should not beadministered concomitantly becausedecreases in nevirapine plasmaconcentrations may reduce the efficacy ofthe drug. | <Nevirapine, advise, rifampin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | aBased on reports of narcotic withdrawal syndrome in patients treated with nevirapine and methadone concurrently, and evidence of decreased plasma concentrations of methadone. | <nevirapine, effect, methadone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketoconazole: In healthy subjects receiving ketoconazole, a CYP3A4 inhibitor, at 200 mg twice daily for 7 days, systemic exposure (AUC) to lapatinib was increased to approximately 3.6-fold of control and half-life increased to 1.7-fold of control. | <ketoconazole, mechanism, lapatinib> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Carbamazepine: In healthy subjects receiving the CYP3A4 inducer, carbamazepine, at 100 mg twice daily for 3 days and 200 mg twice daily for 17 days, systemic exposure (AUC) to lapatinib was decreased approximately 72%. | <carbamazepine, mechanism, lapatinib> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | MAO inhibitors should be used with caution in patients receiving hydralazine. | <MAO inhibitors, advise, hydralazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When other potent parental antihypertensive drugs, such as diazoxide, are used in combination with hydralazine, patients should be continuously observed for several hours for any excessive fall in blood pressure. | <antihypertensive drugs, effect, diazoxide>, <antihypertensive drugs, effect, hydralazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Profound hypotensive episodes may occur when diazoxide infection and hydralazine are used concomitantly. | <diazoxide, effect, hydralazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Propranolol increases hydralazines serum concentrations. | <Propranolol, mechanism, hydralazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | NSAIDs may decrease the hemodynamic effects of hydralazine; | <NSAIDs, effect, hydralazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants. | <ibuprofen, effect, coumarin-type anticoagulants>, <nonsteroidal anti-inflammatory agents, effect, coumarin-type anticoagulants>, <ibuprofen, advise, anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. | <aspirin, effect, nonsteroidal anti-inflammatory agents>, <aspirin, effect, ibuprofen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Methotrexate: Ibuprofen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. | <Ibuprofen, mechanism, methotrexate>, <nonsteroidal anti-inflammatory drugs, mechanism, methotrexate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | This may indicate that ibuprofen could enhance the toxicity of methotrexate. | <ibuprofen, effect, methotrexate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be used if ibuprofen is administered concomitantly with methotrexate. | <ibuprofen, advise, methotrexate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients. | <ibuprofen, effect, furosemide>, <ibuprofen, effect, thiazides> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium: Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. | <Ibuprofen, mechanism, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. | <ibuprofen, advise, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when SUPRAX is administered concomitantly. | <carbamazepine, mechanism, SUPRAX> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Warfarin and Anticoagulants: Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly. | <Warfarin, effect, cefixime>, <Anticoagulants, effect, cefixime> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine: Cimetidine increases nicardipine HCl plasma levels. | <Cimetidine, mechanism, nicardipine HCl> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digoxin: Some calcium blockers may increase the concentration of digitalis preparations in the blood. | <calcium blockers, mechanism, digitalis preparations> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nicardipine HCl usually does not alter the plasma levels of digoxin, however, serum digoxin levels should be evaluated after concomitant therapy with nicardipine HCl is initiated. | <digoxin, advise, nicardipine HCl> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Plasma concentrations of cyclosporine should therefore be closely monitored, and its dosage reduced accordingly, in patients treated with nicardipine. | <cyclosporine, advise, nicardipine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients treated with proton pump inhibitors and warfarin concomitantly may need to be monitored for increases in INR and prothrombin time. | <proton pump inhibitors, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of esomeprazole 30 mg and diazepam, a CYP2C19 substrate, resulted in a 45% decrease in clearance of diazepam. | <esomeprazole, mechanism, diazepam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg, ketoconazole, iron salts and digoxin). | <esomeprazole, mechanism, ketoconazole>, <esomeprazole, mechanism, iron>, <esomeprazole, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant administration of clarithromycin with pimozide is contraindicated. | <clarithromycin, advise, pimozide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aspirin: Concomitant administration of diclofenac and aspirin is not recommended because diclofenac is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels, and AUC values. | <diclofenac, advise, aspirin>, <diclofenac, mechanism, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anticoagulants: While studies have not shown diclofenac to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. | <diclofenac, advise, NSAIDs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because prostaglandins play an important role in hemostasis, and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including diclofenac, and warfarin requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required. | <NSAIDs, advise, warfarin>, <diclofenac, advise, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ingestion of diclofenac may increase serum concentrations of digoxin and methotrexate and increase cyclosporine s nephrotoxicity. | <diclofenac, mechanism, digoxin>, <diclofenac, mechanism, methotrexate>, <diclofenac, effect, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients who begin taking diclofenac or who increase their diclofenac dose or any other NSAID while taking digoxin, methotrexate, or cyclosporine may develop toxicity characteristics for these drugs. | <diclofenac, effect, digoxin>, <diclofenac, effect, methotrexate>, <diclofenac, effect, cyclosporine>, <NSAID, effect, digoxin>, <NSAID, effect, methotrexate>, <NSAID, effect, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lithium: Diclofenac decreases lithium renal clearance and increases lithium plasma levels. | <Diclofenac, mechanism, lithium>, <Diclofenac, mechanism, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients taking diclofenac and lithium concomitantly, lithium toxicity may develop. | <diclofenac, effect, lithium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of diclofenac that necessitated changes in the doses of such agents. | <insulin, effect, diclofenac>, <hypoglycemic agents, effect, diclofenac> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A direct causal relationship has not been established, but physicians should consider the possibility that diclofenac may alter a diabetic patient s response to insulin or oral hypoglycemic agents. | <diclofenac, effect, insulin>, <diclofenac, effect, hypoglycemic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Diuretics: Diclofenac and other NSAIDs can inhibit the activity of diuretics. | <Diclofenac, effect, diuretics>, <NSAIDs, effect, diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of diclofenac therapy. | <phenobarbital, effect, diclofenac> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Protein Binding In vitro, diclofenac interferes minimally or not at all with the protein binding of salicylic acid (20% decrease in binding), tolbutamide, prednisolone (10% decrease in binding), or warfarin. | <diclofenac, mechanism, salicylic acid>, <diclofenac, mechanism, tolbutamide>, <diclofenac, mechanism, prednisolone>, <diclofenac, mechanism, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Renal function should be monitored carefully if high doses of aminoglycosides are to be administered with MAXIPIME because of the increased potential of nephrotoxicity and ototoxicity of aminoglycoside antibiotics. | <aminoglycosides, advise, MAXIPIME> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as furosemide. | <cephalosporins, effect, diuretics>, <cephalosporins, effect, furosemide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Potassium-depleting diuretics are a major contributing factor to digitalis toxicity. | <Potassium-depleting diuretics, effect, digitalis> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and/or in volume of distribution of the drug, with the implication that digitalis intoxication may result. | <Quinidine, mechanism, digoxin>, <verapamil, mechanism, digoxin>, <amiodarone, mechanism, digoxin>, <propafenone, mechanism, digoxin>, <indomethacin, mechanism, digoxin>, <itraconazole, mechanism, digoxin>, <alprazolam, mechanism, digoxin>, <spironolactone, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Erythromycin and clarithromycin (and possibly other macrolide antibiotics) and tetracycline may increase digoxin absorption in patients who inactivate digoxin by bacterial metabolism in the lower intestine, so that digitalis intoxication may result. | <Erythromycin, mechanism, digoxin>, <clarithromycin, mechanism, digoxin>, <macrolide antibiotics, mechanism, digoxin>, <tetracycline, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Propantheline and diphenoxylate, by decreasing gut motility, may increase digoxin absorption. | <Propantheline, mechanism, digoxin>, <diphenoxylate, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids, kaolin-pectin, sulfasalazine, neomycin, cholestyramine, certain anticancer drugs, and metoclopramide may interfere with intestinal digoxin absorption, resulting in unexpectedly low serum concentrations. | <Antacids, mechanism, digoxin>, <kaolin, mechanism, digoxin>, <sulfasalazine, mechanism, digoxin>, <neomycin, mechanism, digoxin>, <cholestyramine, mechanism, digoxin>, <metoclopramide, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rifampin may decrease serum digoxin concentration, especially in patients with renal dysfunction, by increasing the non-renal clearance of digoxin. | <Rifampin, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Thyroid administration to a digitalized, hypothyroid patient may increase the dose requirement of digoxin. | <Thyroid, advise, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concomitant use of digoxin and sympathomimetics increases the risk of cardiac arrhythmias. | <digoxin, effect, sympathomimetics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although beta-adrenergic blockers or calcium channel blockers and digoxin may be useful in combination to control atrial fibrillation, their additive effects on AV node conduction can result in advanced or complete heart block. | <beta-adrenergic blockers, effect, digoxin>, <calcium channel blockers, effect, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a multiple dose study of theophylline (400 mg once daily for 3 days) and cetirizine (20 mg once daily for 3 days), a 16% decrease in the clearance of cetirizine was observed. | <theophylline, mechanism, cetirizine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | There was a small decrease in the clearance of cetirizine caused by a 400-mg dose of theophylline; | <cetirizine, mechanism, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Preliminary data which suggest that dapsone may inhibit the anti-inflammatory activity of Lamprene have not been confirmed. | <dapsone, effect, Lamprene> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If leprosy-associated inflammatory reactions develop in patients being treated with dapsone and clofazimine, it is still advisable to continue treatment with both drugs. | <dapsone, advise, clofazimine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Phenothiazines - Taking piperazine and a phenothiazine together may increase the risk of convulsions (seizures). | <piperazine, effect, phenothiazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Pyrantel (e.g., Antiminth) - Taking piperazine and pyrantel together may decrease the effects of piperazine. | <piperazine, effect, pyrantel> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Diphenhydramine hydrochloride has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc). | <Diphenhydramine hydrochloride, effect, alcohol>, <Diphenhydramine hydrochloride, effect, CNS depressants>, <Diphenhydramine hydrochloride, effect, hypnotics>, <Diphenhydramine hydrochloride, effect, sedatives>, <Diphenhydramine hydrochloride, effect, tranquilizers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | MAO inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. | <MAO inhibitors, effect, antihistamines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be exercised when anticoagulants are given in conjunction with Atromid-S. | <anticoagulants, advise, Atromid-S> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Atromid-S may displace acidic drugs such as phenytoin or tolbutamide from their binding sites. | <Atromid-S, mechanism, phenytoin>, <Atromid-S, mechanism, tolbutamide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The hypoglycemic effect of tolbutamide has been reported to increase when Atromid-S is given concurrently. | <tolbutamide, effect, Atromid-S> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Fulminant rhabdomyolysis has been seen as early as three weeks after initiation of combined therapy with another fibrate and lovastatin but may be seen after several months. | <fibrate, effect, lovastatin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | For these reasons, it is felt that, in most subjects who have had an unsatisfactory lipid response to either drug alone, the possible benefits of combined therapy with lovastatin and a fibrate do not outweigh the risks of severe myopathy, rhabdomyolysis, and acute renal failure. | <lovastatin, effect, fibrate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, the combined use of lovastatin with fibrates should generally be avoided. | <lovastatin, advise, fibrates> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Treatment with PEGASYS once weekly for 4 weeks in healthy subjects was associated with an inhibition of P450 1A2 and a 25% increase in theophylline AUC. | <PEGASYS, mechanism, theophylline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Theophylline serum levels should be monitored and appropriate dose adjustments considered for patients given both theophylline and PEGASYS. | <theophylline, advise, PEGASYS> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nucleoside Analogues Didanosine Co-administration of COPEGUS and didanosine is not recommended. | <COPEGUS, advise, didanosine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Stavudine and Zidovudine Ribavirin can antagonize the in vitro antiviral activity of stavudine and zidovudine against HIV. | <Ribavirin, effect, stavudine>, <Ribavirin, effect, zidovudine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The adverse effects of CAMPTOSAR, such as myelosuppression and diarrhea, would be expected to be exacerbated by other antineoplastic agents having similar adverse effects. | <CAMPTOSAR, effect, antineoplastic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Lymphocytopenia has been reported in patients receiving CAMPTOSAR, and it is possible that the administration of dexamethasone as antiemetic prophylaxis may have enhanced the likelihood of this effect. | <CAMPTOSAR, effect, dexamethasone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The incidence of akathisia in clinical trials of the weekly dosage schedule was greater (8.5%, 4/47 patients) when prochlorperazine was administered on the same day as CAMPTOSAR than when these drugs were given on separate days (1.3%, 1/80 patients). | <prochlorperazine, effect, CAMPTOSAR> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It would be expected that laxative use during therapy with CAMPTOSAR would worsen the incidence or severity of diarrhea, but this has not been studied. | <laxative, effect, CAMPTOSAR> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In view of the potential risk of dehydration secondary to vomiting and/or diarrhea induced by CAMPTOSAR, the physician may wish to withhold diuretics during dosing with CAMPTOSAR and, certainly, during periods of active vomiting or diarrhea. | <diuretics, effect, CAMPTOSAR> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concurrent administration of etanercept (another TNF -blocking agent) and anakinra (an interleukin-1 antagonist) has been associated with an increased risk of serious infections, and increased risk of neutropenia and no additional benefit compared to these medicinal products alone. | <etanercept, effect, anakinra> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Other TNFa-blocking agents (including REMICADE) used in combination with anakinra may also result in similar toxicities. | <TNFa-blocking agents, effect, anakinra>, <REMICADE, effect, anakinra> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although acid-base and electrolyte disturbances were not reported in the clinical trials with dorzolamide, these disturbances have been reported with oral carbonic anhydrase inhibitors and have, in some instances, resulted in drug interactions (e.g., toxicity associated with high-dose salicylate therapy). | <dorzolamide, effect, carbonic anhydrase inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Mercaptopurine/Azathioprine: Allopurinol inhibits the enzymatic oxidation of mercaptopurine and azathioprine to 6-thiouric acid. | <Allopurinol, mechanism, mercaptopurine>, <Allopurinol, mechanism, azathioprine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients receiving mercaptopurine (Purinethol) or azathioprine (Imuran), the concomitant administration of 300-600 mg of allopurinol per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. | <allopurinol, advise, mercaptopurine>, <allopurinol, advise, azathioprine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Dicumarol: It has been reported that allopurinol prolongs the half-life of the anticoagulant, dicumarol. | <allopurinol, mechanism, dicumarol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Uricosuric Agents: Since the excretion of oxipurinol is similar to that of urate, uricosuric agents, which increase the excretion of urate, are also likely to increase the excretion of oxipurinol and thus lower the degree of inhibition of xanthine oxidase. | <uricosuric agents, mechanism, oxipurinol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant administration of uricosuric agents and allopurinol has been associated with a decrease in the excretion of oxypurines (hypoxanthine and xanthine) and an increase in urinary uric acid excretion compared with that observed with allopurinol alone. | <uricosuric agents, mechanism, allopurinol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Thiazide Diuretics: The reports that the concomitant use of allopurinol and thiazide diuretics may contribute to the enhancement of allopurinol toxicity in some patients have been reviewed in an attempt to establish a cause-and-effect relationship and a mechanism of causation. | <allopurinol, effect, thiazide diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although a causal mechanism and a cause-and-effect relationship have not been established, current evidence suggests that renal function should be monitored in patients on thiazide diuretics and allopurinol even in the absence of renal failure, and dosage levels should be even more conservatively adjusted in those patients on such combined therapy if diminished renal function is detected.. | <thiazide diuretics, advise, allopurinol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ampicillin/Amoxicillin: An increase in the frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with allopurinol compared to patients who are not receiving both drugs. | <ampicillin, effect, allopurinol>, <amoxicillin, effect, allopurinol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cytotoxic Agents: Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic disease, except leukemia, in the presence of allopurinol. | <cyclophosphamide, effect, allopurinol>, <cytotoxic agents, effect, allopurinol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chlorpropamide: Chlorpropamides plasma half-life may be prolonged by allopurinol, since allopurinol and chlorpropamide may compete for excretion in the renal tubule. | <Chlorpropamide, mechanism, allopurinol>, <allopurinol, mechanism, chlorpropamide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The risk of hypoglycemia secondary to this mechanism may be increased if allopurinol and chlorpropamide are given concomitantly in the presence of renal insufficiency. | <allopurinol, effect, chlorpropamide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclosporin: Reports indicate that cyclosporine levels may be increased during concomitant treatment with allopurinol sodium for injection. | <cyclosporine, mechanism, allopurinol sodium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Catecholamine-depleting drugs, such as reserpine, may have an additive effect when given with beta-blocking agents. | <Catecholamine-depleting drugs, effect, beta-blocking agents>, <reserpine, effect, beta-blocking agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients treated with acebutolol plus catecholamine depletors should, therefore, be observed closely for evidence of marked bradycardia or hypotension which may present as vertigo, syncope/presyncope, or orthostatic changes in blood pressure without compensatory tachycardia. | <acebutolol, advise, catecholamine depletors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Exaggerated hypertensive responses have been reported from the combined use of beta-adrenergic antagonists and alpha-adrenergic stimulants, including those contained in proprietary cold remedies and vasoconstrictive nasal drops. | <beta-adrenergic antagonists, effect, alpha-adrenergic stimulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Blunting of the antihypertensive effect of beta-adrenoceptor blocking agents by nonsteroidal anti-inflammatory drugs has been reported. | <beta-adrenoceptor blocking agents, effect, nonsteroidal anti-inflammatory drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | These antibiotics should be used in the myasthenic patient only where definitely indicated, and then careful adjustment should be made of adjunctive anticholinesterase dosage. | <antibiotics, advise, anticholinesterase> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Betaseron administration to three cancer patients over a dose range of 0.025 mg to 2.2 mg led to a dose-dependent inhibition of antipyrine elimination.14 The effect of alternate-day administration of 0.25 mg of Betaseron on drug metabolism in MS patients is unknown. | <Betaseron, mechanism, antipyrine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aminoglycosides: The mixing of piperacillin with an aminoglycoside in vitro can result in substantial inactivation of the aminoglycoside. | <piperacillin, effect, aminoglycoside> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Vecuronium: When used in the perioperative period, piperacillin has been implicated in the prolongation of the neuromuscular blockade of vecuronium. | <piperacillin, effect, vecuronium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In one controlled clinical study, the ureidopenicillins, including piperacillin, were reported to prolong the action of vecuronium. | <piperacillin, effect, vecuronium> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Due to their similar mechanism of action, it is expected that the neuromuscular blockade produced by any of the non-depolarizing muscle relaxants could be prolonged in the presence of piperacillin. | <non-depolarizing muscle relaxants, effect, piperacillin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid: The oral combination of probenecid before intramuscular injection of PIPRACIL produces an increase in piperacillin peak serum level of about 30%. | <probenecid, mechanism, PIPRACIL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Methotrexate: Piperacillin sodium may reduce the excretion of methotrexate. | <Piperacillin sodium, mechanism, methotrexate> |