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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin. | <Beta-blockers, effect, insulin>, <clonidine, effect, insulin>, <lithium, effect, insulin>, <alcohol, effect, insulin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The action of the benzodiazepines may be potentiated by anticonvulsants, antihistamines, alcohol, barbiturates, monoamine oxidase inhibitors, narcotics, phenothiazines, psychotropic medications, or other drugs that produce CNS depression. | <benzodiazepines, effect, anticonvulsants>, <benzodiazepines, effect, antihistamines>, <benzodiazepines, effect, alcohol>, <benzodiazepines, effect, barbiturates>, <benzodiazepines, effect, monoamine oxidase inhibitors>, <benzodiazepines, effect, narcotics>, <benzodiazepines, effect, phenothiazines>, <benzodiazepines, effect, psychotropic medications> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | While no in vivo drug-drug interaction studies were conducted between estazolam and inducers of CYP3A, compounds that are potent CYP3A inducers (such as carbamazepine, phenytoin, rifampin, and barbiturates) would be expected to decrease estazolam concentrations. | <estazolam, mechanism, carbamazepine>, <estazolam, mechanism, phenytoin>, <estazolam, mechanism, rifampin>, <estazolam, mechanism, barbiturates>, <estazolam, mechanism, estazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Consequently, estazolam should be avoided in patients receiving ketoconazole and itraconazole, which are very potent inhibitors of CYP3A. | <estazolam, advise, ketoconazole>, <estazolam, advise, itraconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The following are examples of drugs known to inhibit the metabolism of other related benzodiazepines, presumably through inhibition of CYP3A: nefazodone, fluvoxamine, cimetidine, diltiazem, isoniazide, and some macrolide antibiotics. | <benzodiazepines, mechanism, nefazodone>, <benzodiazepines, mechanism, fluvoxamine>, <benzodiazepines, mechanism, cimetidine>, <benzodiazepines, mechanism, diltiazem>, <benzodiazepines, mechanism, isoniazide>, <benzodiazepines, mechanism, macrolide antibiotics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ethopropazine may interact with alcohol or other CNS depressants, causing increased sedative effects. | <Ethopropazine, effect, alcohol>, <Ethopropazine, effect, CNS depressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ethopropazine can interact with chlorpromazine, increasing the metabolism of chlorpromazine. | <Ethopropazine, mechanism, chlorpromazine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Catecholamine-depleting drugs, e.g., reserpine, may have an additive effect when given with beta blocking agents. | <reserpine, effect, beta blocking agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | BREVIBLOC concentrations were equivocally higher when given with warfarin, but this is not likely to be clinically important. | <BREVIBLOC, mechanism, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When digoxin and BREVIBLOC were concomitantly administered intravenously to normal volunteers, there was a 10-20% increase in digoxin blood levels at some time points. | <digoxin, mechanism, BREVIBLOC> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When intravenous morphine and BREVIBLOC were concomitantly administered in normal subjects, no effect on morphine blood levels was seen, but BREVIBLOC steady-state blood levels were increased by 46% in the presence of morphine. | <BREVIBLOC, mechanism, morphine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The onset of neuromuscular blockade by succinylcholine was unaffected by BREVIBLOC, but the duration of neuromuscular blockade was prolonged from 5 minutes to 8 minutes. | <succinylcholine, effect, BREVIBLOC> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although the interactions observed in these studies do not appear to be of major clinical importance, BREVIBLOC should be titrated with caution in patients being treated concurrently with digoxin, morphine, succinylcholine or warfarin. | <BREVIBLOC, advise, digoxin>, <BREVIBLOC, advise, morphine>, <BREVIBLOC, advise, succinylcholine>, <BREVIBLOC, advise, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be exercised when considering the use of BREVIBLOC and verapamil in patients with depressed myocardial function. | <BREVIBLOC, advise, verapamil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Additionally, BREVIBLOC should not be used to control supraventricular tachycardia in the presence of agents which are vasoconstrictive and inotropic such as dopamine, epinephrine, and norepinephrine because of the danger of blocking cardiac contractility when systemic vascular resistance is high. | <BREVIBLOC, advise, dopamine>, <BREVIBLOC, advise, epinephrine>, <BREVIBLOC, advise, norepinephrine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drug-Drug Interactions Albuterol - STRATTERA should be administered with caution to patients being treated with systemically-administered (oral or intravenous) albuterol (or other beta2 agonists) because the action of albuterol on the cardiovascular system can be potentiated resulting in increases in heart rate and blood pressure. | <STRATTERA, advise, albuterol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Dosage adjustment of STRATTERA may be necessary when coadministered with CYP2D6 inhibitors, e.g., paroxetine, fluoxetine, and quinidine. | <STRATTERA, advise, paroxetine>, <STRATTERA, advise, fluoxetine>, <STRATTERA, advise, quinidine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In EM individuals treated with paroxetine or fluoxetine, the AUC of atomoxetine is approximately 6- to 8-fold and Css,max is about 3- to 4-fold greater than atomoxetine alone. | <paroxetine, mechanism, atomoxetine>, <fluoxetine, mechanism, atomoxetine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Possible drug interactions of HUMORSOL with succinylcholine or with other anticholinesterase agents. | <HUMORSOL, int, succinylcholine>, <HUMORSOL, int, anticholinesterase agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When you are using idoxuridine, it is especially important that your health care professional know if you are using the following: Eye product containing boric acid. | <idoxuridine, advise, boric acid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Boric acid may interact with the idoxuridine preparation causing a gritty substance to form or may interact with the preservative in the idoxuridine preparation causing a toxic effect in the eye. | <Boric acid, mechanism, idoxuridine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Co-administration of nelfinavir at steady-state with a single dose of azithromycin (2 x 600 mg tablets) results in increased azithromycin serum concentrations. | <nelfinavir, effect, azithromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although a dose adjustment of azithromycin is not recommended when administered in combination with nelfinavir, close monitoring for known side effects of azithromycin, such as liver enzyme abnormalities and hearing impairment, is warranted. | <azithromycin, advise, nelfinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, prudent medical practice dictates careful monitoring of prothrombin time in all patients treated with azithromycin and warfarin concomitantly. | <azithromycin, advise, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concurrent use of macrolides and warfarin in clinical practice has been associated with increased anticoagulant effects. | <macrolides, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When used in therapeutic doses, azithromycin had a modest effect on the pharmacokinetics of atorvastatin, carbamazepine, cetirizine, didanosine, efavirenz, fluconazole, indinavir, midazolam, rifabutin, sildenafil, theophylline (intravenous and oral), triazolam, trimethoprim/sulfamethoxazole or zidovudine. | <azithromycin, mechanism, atorvastatin>, <azithromycin, mechanism, carbamazepine>, <azithromycin, mechanism, cetirizine>, <azithromycin, mechanism, didanosine>, <azithromycin, mechanism, efavirenz>, <azithromycin, mechanism, fluconazole>, <azithromycin, mechanism, indinavir>, <azithromycin, mechanism, midazolam>, <azithromycin, mechanism, rifabutin>, <azithromycin, mechanism, sildenafil>, <azithromycin, mechanism, theophylline>, <azithromycin, mechanism, triazolam>, <azithromycin, mechanism, trimethoprim>, <azithromycin, mechanism, sulfamethoxazole>, <azithromycin, mechanism, zidovudine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Co-administration with efavirenz or fluconazole had a modest effect on the pharmacokinetics of azithromycin. | <efavirenz, mechanism, azithromycin>, <fluconazole, mechanism, azithromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Co-administration of probenecid with acyclovir has been shown to increase the mean half-life and the area under the concentration-time curve. | <probenecid, mechanism, acyclovir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rifampin, an inducer of drug metabolism, decreased the concentrations of losartan and its active metabolite. | <Rifampin, mechanism, losartan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Fluconazole, an inhibitor of P450 2C9, decreased active metabolite concentration and increased losartan concentration. | <Fluconazole, mechanism, losartan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | As with other antihypertensive agents, the antihypertensive effect of losartan may be blunted by the non-steroidal anti-inflammatory drug indomethacin | <losartan, effect, indomethacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. | <isosorbide mononitrate, effect, vasodilators> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. | <calcium channel blockers, effect, organic nitrates> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid may decrease renal tubular secretion of cephalosporins when used concurrently, resulting in increased and more prolonged cephalosporin blood levels. | <Probenecid, mechanism, cephalosporins> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Levothyroxine Sodium Absorption: The following agents may bind and decrease absorption of levothyroxine sodium from the gastrointestinal tract: aluminum hydoxide, cholestyramine resin, colestipol hydrochloride, ferrous sulfate, sodium polystyrene sulfonate, soybean flour (e.g., infant formula), sucralfate. | <levothyroxine sodium, mechanism, aluminum hydoxide>, <levothyroxine sodium, mechanism, cholestyramine>, <levothyroxine sodium, mechanism, colestipol hydrochloride>, <levothyroxine sodium, mechanism, ferrous sulfate>, <levothyroxine sodium, mechanism, sodium polystyrene sulfonate>, <levothyroxine sodium, mechanism, sucralfate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Binding to Serum Proteins: The following agents may either inhibit levothyroxine sodium binding to serum proteins or alter the concentrations of serum binding proteins: androgens and related anabolic hormones, asparaginase, clofibrate, estrogens and estrogen-containing compounds, 5-fluorouracil, furosemide, glucocorticoids, meclofenamic acid, mefenamic acid, methadone, perphenazine, phenylbutazone, phenytoin, salicylates, tamoxifen. | <levothyroxine sodium, mechanism, androgens>, <levothyroxine sodium, mechanism, anabolic hormones>, <levothyroxine sodium, mechanism, asparaginase>, <levothyroxine sodium, mechanism, clofibrate>, <levothyroxine sodium, mechanism, estrogens>, <levothyroxine sodium, mechanism, estrogen-containing compounds>, <levothyroxine sodium, mechanism, 5-fluorouracil>, <levothyroxine sodium, mechanism, furosemide>, <levothyroxine sodium, mechanism, glucocorticoids>, <levothyroxine sodium, mechanism, meclofenamic acid>, <levothyroxine sodium, mechanism, mefenamic acid>, <levothyroxine sodium, mechanism, methadone>, <levothyroxine sodium, mechanism, perphenazine>, <levothyroxine sodium, mechanism, phenylbutazone>, <levothyroxine sodium, mechanism, phenytoin>, <levothyroxine sodium, mechanism, salicylates>, <levothyroxine sodium, mechanism, tamoxifen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketamine: Marked hypertension and tachycardia have been reported in association with concomitant administration of levothyroxine sodium and ketamine. | <levothyroxine sodium, effect, ketamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids and sucralfate: Sucralfate and antacids containing magnesium or aluminum, as well as formulations containing divalent and trivalent cations such as Videx (didanosine), chewable/buffered tablets or the pediatric powder for oral solution can form chelation complexes with lomefloxacin and interfere with its bioavailability. | <Sucralfate, mechanism, lomefloxacin>, <magnesium, mechanism, lomefloxacin>, <aluminum, mechanism, lomefloxacin>, <Videx, mechanism, lomefloxacin>, <didanosine, mechanism, lomefloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Sucralfate administered 2 hours before lomefloxacin resulted in a slower absorption (mean C max decreased by 30% and mean T max increased by 1 hour) and a lesser extent of absorption (mean AUC decreased by approximately 25%). | <Sucralfate, mechanism, lomefloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Magnesium- and aluminum-containing antacids, administered concomitantly with lomefloxacin, significantly decreased the bioavailability (48%) of lomefloxacin. | <Magnesium, mechanism, lomefloxacin>, <aluminum, mechanism, lomefloxacin>, <antacids, mechanism, lomefloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Separating the doses of antacid and lomefloxacin minimizes this decrease in bioavailability; | <antacid, mechanism, lomefloxacin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Other quinolones have demonstrated moderate to marked interference with the metabolism of caffeine, resulting in a reduced clearance, a prolongation of plasma half-life, and an increase in symptoms that accompany high levels of caffeine. | <quinolones, mechanism, caffeine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine: Cimetidine has been demonstrated to interfere with the elimination of other quinolones. | <Cimetidine, mechanism, quinolones> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclosporine: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with other members of the quinolone class. | <cyclosporine, mechanism, quinolone class> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Warfarin: Quinolones may enhance the effects of the oral anticoagulant, warfarin, or its derivatives. | <Quinolones, effect, anticoagulant>, <Quinolones, effect, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aprepitant has been shown to induce the metabolism of S(-) warfarin and tolbutamide, which are metabolized through CYP2C9. | <Aprepitant, mechanism, S(-) warfarin>, <Aprepitant, mechanism, tolbutamide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Coadministration of Aprepitant with these drugs or other drugs that are known to be metabolized by CYP2C9, such as phenytoin, may result in lower plasma concentrations of these drugs. | <Aprepitant, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Corticosteroids: Dexamethasone: Aprepitant, when given as a regimen of 125mg with dexamethasone coadministered orally as 20 mg on Day 1, and Aprepitant when given as 80 mg/day with dexamethasone coadministered orally as 8 mg on Days 2 through 5, increased the AUC of dexamethasone, a CYP3A4 substrate by 2.2-fold, on Days 1 and 5. | <Aprepitant, mechanism, dexamethasone>, <Aprepitant, mechanism, dexamethasone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The oral dexamethasone doses should be reduced by approximately 50% when coadministered with Aprepitant, to achieve exposures of dexamethasone similar to those obtained when it is given without Aprepitant. | <dexamethasone, advise, Aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The daily dose of dexamethasone administered in clinical studies with Aprepitant reflects an approximate 50% reduction of the dose of dexamethasone. | <dexamethasone, mechanism, Aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aprepitant, when given as a regimen of 125 mg on Day 1 and 80 mg/day on Days 2 and 3, increased the AUC of methylprednisolone, a CYP3A4 substrate, by 1.34-fold on Day 1 and by 2.5-fold on Day 3, when methylprednisolone was coadministered intravenously as 125 mg on Day 1 and orally as 40 mg on Days 2 and 3. | <Aprepitant, mechanism, methylprednisolone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The IV methylprednisolone dose should be reduced by approximately 25%, and the oral methylprednisolone dose should be reduced by approximately 50% when coadministered with Aprepitant to achieve exposures of methylprednisolone similar to those obtained when it is given without Aprepitant. | <methylprednisolone, advise, Aprepitant>, <methylprednisolone, advise, Aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although there was no effect of Aprepitant on the plasma AUC of R(+) or S(-) warfarin determined on Day 3, there was a 34% decrease in S(-)warfarin (a CYP2C9 substrate) trough concentration accompanied by a 14% decrease in the prothrombin time (reported as International Normalized Ratio or INR) 5 days after completion of dosing with Aprepitant. | <S(-)warfarin, mechanism, Aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients on chronic warfarin therapy, the prothrombin time (INR) should be closely monitored in the 2-week period, particularly at 7 to 10 days, following initiation of the 3-day regimen of Aprepitant with each chemotherapy cycle. | <warfarin, advise, Aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tolbutamide: Aprepitant, when given as 125 mg on Day 1 and 80 mg/day on Days 2 and 3, decreased the AUC of tolbutamide (a CYP2C9 substrate) by 23% on Day 4, 28% on Day 8, and 15% on Day 15, when a single dose of tolbutamide 500 mg was admini,stered orally prior to the administration of the 3-day regimen of Aprepitant and on Days 4,8, and 15. | <tolbutamide, mechanism, Aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Oral contraceptives: Aprepitant, when given once daily for 14 days as a 100-mg capsule with an oral contraceptive containing 35 mcg of ethinyl estradiol and 1 mg of norethindrone, decreased the AUC of ethinyl estradiol by 43%, and decreased the AUC of norethindrone by 8%; | <Aprepitant, mechanism, ethinyl estradiol>, <Aprepitant, mechanism, norethindrone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | therefore, the efficacy of oral contraceptives during administration of Aprepitant may be reduced. | <contraceptives, effect, Aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although a 3-day regimen of Aprepitant given concomitantly with oral contraceptives has not been studied, alternative or back-up methods of contraception should be used. | <Aprepitant, advise, contraceptives> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Midazolam: Aprepitant increased the AUC of midazolam, a sensitive CYP3A4 substrate, by 2.3-fold on Day 1 and 3.3-fold on Day 5, when a single oral dose of midazolam 2 mg was coadministered on Day 1 and Day 5 of a regimen of Aprepitant 125 mg on Day 1 and 80 mg/day on Days 2 through 5. | <Aprepitant, mechanism, midazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The potential effects of increased plasma concentrations of midazolam or other benzodiazepines metabolized via CYP3A4 (alprazolam, triazolam) should be considered when coadministering these agents with Aprepitant. | <midazolam, advise, Aprepitant>, <benzodiazepines, advise, Aprepitant>, <alprazolam, advise, Aprepitant>, <triazolam, advise, Aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Aprepitant increased the AUC of midazolam by 25% on Day 4 and decreased the AUC of midazolam by 19% on Day 8 relative to the dosing of Aprepitant on Days 1 through 3. | <Aprepitant, mechanism, midazolam>, <Aprepitant, mechanism, midazolam> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Consequently, concomitant administration of Aprepitant with strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, nelfinavir) should be approached with caution. | <Aprepitant, advise, ketoconazole>, <Aprepitant, advise, itraconazole>, <Aprepitant, advise, nefazodone>, <Aprepitant, advise, troleandomycin>, <Aprepitant, advise, clarithromycin>, <Aprepitant, advise, ritonavir>, <Aprepitant, advise, nelfinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because moderate CYP3A4 inhibitors (e.g., diltiazem) result in 2-fold increase in plasma concentrations of aprepitant, concomitant administration should also be approached with caution. | <diltiazem, advise, aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | therefore, coadministration of Aprepitant with drugs that strongly induce CYP3A4 activity (e.g., rifampin, carbamazepine, phenytoin) may result in reduced plasma concentrations of aprepitant that may result in decreased efficacy of Aprepitant. | <Aprepitant, mechanism, rifampin>, <Aprepitant, mechanism, phenytoin>, <Aprepitant, mechanism, aprepitant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketoconazole: When a single 125-mg dose of Aprepitant was administered on Day5 of a 10-day regimen of 400 mg/day of ketoconazole, a strong CYP3A4 inhibitor, the AUC of aprepitant increased approximately 5-fold and the mean terminal half-life of aprepitant increased approximately 3-fold. | <Aprepitant, mechanism, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Rifampin: When a single 375-mg dose of Aprepitant was administered on Day9 of a 14-day regimen of 600 mg/day of rifampin, a strong CYP3A4 inducer, the AUC of aprepitant decreased approximately 11-fold and the mean terminal half-life decreased approximately 3-fold. | <Aprepitant, mechanism, rifampin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Diltiazem: In patients with mild to moderate hypertension, administration of aprepitant once daily, as a tablet formulation comparable to 230 mg of the capsule formulation, with diltiazem 120 mg 3 times daily for 5 days, resulted in a 2-fold increase of aprepitant AUC and a simultaneous 1.7-fold increase of diltiazem AUC. | <aprepitant, mechanism, diltiazem> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Paroxetine: Coadministration of once daily doses of aprepitant, as a tablet formulation comparable to 85 mg or 170 mg of the capsule formulation, with paroxetine 20 mg once daily, resulted in a decrease in AUC by approximately 25% and Cmax, by approximately 20% of both aprepitant and paroxetine. | <aprepitant, mechanism, paroxetine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. | <tetracyclines, advise, anticoagulant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tetracyclines in conjunction with penicillin. | <tetracyclines, advise, penicillin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations. | <tetracyclines, mechanism, aluminum>, <tetracyclines, mechanism, calcium>, <tetracyclines, mechanism, magnesium>, <tetracyclines, mechanism, iron> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Absorption of tetracycline is impaired by bismuth subsalicylate. | <tetracycline, mechanism, bismuth subsalicylate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline. | <Barbiturates, mechanism, doxycycline>, <carbamazepine, mechanism, doxycycline>, <phenytoin, mechanism, doxycycline> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concurrent use of tetracycline and Penthrane (methoxyflurane) has been reported to result in fatal renal toxicity. | <tetracycline, effect, Penthrane>, <tetracycline, effect, methoxyflurane> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concurrent use of tetracycline may render oral contraceptives less effective. | <tetracycline, effect, contraceptives> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In addition to bleeding associated with heparin and vitamin K antagonists, drugs that alter platelet function (such as acetylsalicylic acid, dipyridamole and Abciximab) may increase the risk of bleeding if administered prior to, during, or after Activase therapy. | <heparin, effect, Activase>, <vitamin K antagonists, effect, Activase>, <acetylsalicylic acid, int, Activase>, <dipyridamole, effect, Activase>, <Abciximab, effect, Activase> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients receiving other narcotic analgesics, antipsychotics, antianxiety agents, or other CNS depressants (including alcohol) concomitantly with hydrocodone and acetaminophen tablets may exhibit an additive CNS depression. | <narcotic analgesics, effect, hydrocodone>, <antipsychotics, effect, hydrocodone>, <antianxiety agents, effect, hydrocodone>, <CNS depressants, effect, hydrocodone>, <alcohol, effect, hydrocodone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The use of MAO inhibitors or tricyclic antidepressants with hydrocodone preparations may increase the effect of either the antidepressant or hydrocodone. | <MAO inhibitors, effect, hydrocodone>, <tricyclic antidepressants, effect, hydrocodone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concurrent use of anticholinergics with hydrocodone may produce paralytic ileus. | <anticholinergics, effect, hydrocodone> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Due to a theoretical risk of a pharmacodynamic interaction, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and FROVA within 24 hours of each other should be avoided (see a href= frova_od.htm#CI CONTRAINDICATIONS). | <ergotamine, advise, FROVA>, <ergot-type medications, advise, FROVA>, <dihydroergotamine, advise, FROVA>, <methysergide, advise, FROVA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Selective serotonin reuptake inhibitors (SSRIs) (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) have been reported, rarely, to cause weakness, hyperreflexia, and incoordination when coadministered with 5-HT1 agonists. | <Selective serotonin reuptake inhibitors, effect, 5-HT1 agonists>, <SSRIs, effect, 5-HT1 agonists>, <fluoxetine, effect, 5-HT1 agonists>, <fluvoxamine, effect, 5-HT1 agonists>, <paroxetine, effect, 5-HT1 agonists>, <sertraline, effect, 5-HT1 agonists> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If concomitant treatment with frovatriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised. | <frovatriptan, advise, SSRI> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Avoid the use of preparations such as decongestants and local anesthetics which contain any sympathomimetic amine (e.g., epinephrine, norepinephrine), since it has been reported that tricyclic antidepressants can potentiate the effects of catecholamines. | <decongestants, advise, tricyclic antidepressants>, <anesthetics, advise, tricyclic antidepressants>, <sympathomimetic amine, advise, tricyclic antidepressants>, <epinephrine, advise, tricyclic antidepressants>, <norepinephrine, advise, tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Imipramine hydrochloride may potentiate the effects of CNS depressant drugs. | <Imipramine hydrochloride, effect, CNS depressant drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary. | <imipramine, mechanism, cimetidine>, <imipramine, mechanism, fluoxetine>, <imipramine, mechanism, barbiturates>, <imipramine, mechanism, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The extent to which SSRI-TCA interactions may pose clinical problems will depend on the degree of inhibition, and the pharmacokinetics of the SSRI involved. | <SSRI, int, TCA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Oral neomycin inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. | <neomycin, mechanism, penicillin V>, <neomycin, mechanism, vitamin B-12>, <neomycin, mechanism, methotrexate>, <neomycin, mechanism, 5-fluorouracil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Oral neomycin sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability. | <neomycin sulfate, effect, coumarin>, <neomycin sulfate, effect, anticoagulants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids and kaolin: Antacids and kaolin can reduce absorption of chloroquine; | <Antacids, mechanism, chloroquine>, <kaolin, mechanism, chloroquine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cimetidine: Cimetidine can inhibit the metabolism of chloroquine, increasing its plasma level. | <Cimetidine, mechanism, chloroquine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ampicillin: In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin. | <chloroquine, mechanism, ampicillin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclosporin: After introduction of chloroquine (oral form), a sudden increase in serum cyclosporin level has been reported. | <chloroquine, mechanism, cyclosporin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The coadministration of aspirin decreases the biologic half-life of fenoprofen because of an increase in metabolic clearance that results in a greater amount of hydroxylated fenoprofen in the urine. | <aspirin, mechanism, fenoprofen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Although the mechanism of interaction between fenoprofen and aspirin is not totally known, enzyme induction and displacement of fenoprofen from plasma albumin binding sites are possibilities. | <fenoprofen, mechanism, aspirin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because Nalfon has not been shown to produce any additional effect beyond that obtained with aspirin alone and because aspirin increases the rate of excretion of Nalfon, the concomitant use of Nalfon and salicylates is not recommended. | <aspirin, mechanism, Nalfon>, <Nalfon, advise, salicylates> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Chronic administration of phenobarbital, a known enzyme inducer, may be associated with a decrease in the plasma half-life of fenoprofen. | <phenobarbital, mechanism, fenoprofen> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When phenobarbital is added to or withdrawn from treatment, dosage adjustment of Nalfon may be required. | <phenobarbital, advise, Nalfon> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients receiving coumarin-type anticoagulants, the addition of Nalfon to therapy could prolong the prothrombin time. | <coumarin-type anticoagulants, effect, Nalfon> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients treated with Nalfon may be resistant to the effects of loop diuretics. | <Nalfon, effect, loop diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In patients receiving Nalfon and a steroid concomitantly, any reduction in steroid dosage should be gradual in order to avoid the possible complications of sudden steroid withdrawal. | <Nalfon, advise, steroid> |