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Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | H1 and H2 Blockers - Although not reported, L-histidine, via its metabolism to histamine, might decrease the efficacy of H1 and H2 blockers. | <L-histidine, effect, H1 blockers>, <L-histidine, effect, H2 blockers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving systemic cyclosporine concomitantly. | <quinolones, mechanism, theophylline>, <quinolones, mechanism, caffeine>, <quinolones, effect, warfarin>, <quinolones, effect, cyclosporine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Erythromycin (500 mg t.i.d) produced a 4-fold increase in vardenafil AUC and a 3-fold increase in Cmax when co-administered with Vardenafil 5 mg in healthy volunteers. | <Erythromycin, mechanism, vardenafil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended not to exceed a single 5 mg dose of Vardenafil in a 24-hour period when used in combination with erythromycin. | <Vardenafil, advise, erythromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketoconazole (200 mg once daily) produced a 10-fold increase in vardenafil AUC and a 4-fold increase in Cmax when co-administered with Vardenafil (5 mg) in healthy volunteers. | <Ketoconazole, mechanism, vardenafil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | A 5-mg Vardenafil dose should not be exceeded when used in combination with 200 mg once daily ketoconazole. | <Vardenafil, advise, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Since higher doses of ketoconazole (400 mg daily) may result in higher increases in Cmax and AUC, a single 2.5 mg dose of Vardenafil should not be exceeded in a 24-hour period when used in combination with ketoconazole 400 mg daily. | <Vardenafil, advise, ketoconazole> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | HIV Protease Inhibitors: Indinavir (800 mg t.i.d.) co-administered with Vardenafil 10 mg resulted in a 16-fold increase in vardenafil AUC, a 7-fold increase in vardenafil Cmax and a 2-fold increase in vardenafil half-life. | <Indinavir, mechanism, Vardenafil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended not to exceed a single 2.5 mg Vardenafil dose in a 24-hour period when used in combination with indinavir. | <Vardenafil, advise, indinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ritonavir (600 mg b.i.d.) co-administered with Vardenafil 5 mg resulted in a 49-fold increase in vardenafil AUC and a 13-fold increase in vardenafil Cmax. | <Ritonavir, mechanism, Vardenafil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The interaction is a consequence of blocking hepatic metabolism of vardenafil by ritonavir, a highly potent CYP3A4 inhibitor, which also inhibits CYP2C9. | <vardenafil, mechanism, ritonavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ritonavir significantly prolonged the half-life of vardenafil to 26 hours. | <Ritonavir, mechanism, vardenafil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Consequently, it is recommended not to exceed a single 2.5 mg Vardenafil dose in a 72-hour period when used in combination with ritonavir. | <Vardenafil, advise, ritonavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vivo studies: Nitrates: The blood pressure lowering effects of sublingual nitrates (0.4 mg) taken 1 and 4 hours after vardenafil and increases in heart rate when taken at 1, 4 and 8 hours were potentiated by a 20 mg dose of Vardenafil in healthy middle-aged subjects. | <nitrates, mechanism, vardenafil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Potentiation of the hypotensive effects of nitrates for patients with ischemic heart disease has not been evaluated, and concomitant use of Vardenafil and nitrates is contraindicated. | <Vardenafil, advise, nitrates> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In these patients whose hypertension was controlled with nifedipine, Vardenafil 20 mg produced mean additional supine systolic/diastolic blood pressure reductions of 6/5 mm Hg compared to placebo. | <nifedipine, effect, Vardenafil> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Alpha-blockers: When Vardenafil 10 or 20 mg was given to healthy volunteers either simultaneously or 6 hours after a 10 mg dose of terazosin, significant hypotension developed in a substantial number of subjects. | <Vardenafil, effect, terazosin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | With simultaneous dosing of Vardenafil 10 mg and terazosin 10 mg, 6 of 8 subjects experienced a standing systolic blood pressure of less than 85 mm Hg. | <Vardenafil, effect, terazosin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | With simultaneous dosing of Vardenafil 20 mg and terazosin 10 mg, 2 of 9 subjects experienced a standing systolic blood pressure of less than 85 mm Hg. | <Vardenafil, effect, terazosin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When Vardenafil dosing was separated from terazosin 10 mg by 6 hours, 7 of 28 subjects who received 20 mg of Vardenafil experienced a decrease in standing systolic blood pressure below 85 mm Hg. | <Vardenafil, effect, terazosin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a similar study with tamsulosin in healthy volunteers, 1 of 24 subjects dosed with Vardenafil 20 mg and tamsulosin 0.4 mg separated by 6 hours experienced a standing systolic blood pressure below 85 mm Hg. | <Vardenafil, effect, tamsulosin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Two of 16 subjects dosed simultaneously with Vardenafil 10 mg and tamsulosin 0.4 mg experienced a standing systolic blood pressure below 85 mm Hg. | <Vardenafil, effect, tamsulosin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Based on these data, Vardenafil should not be used in patients on alpha-blocker therapy. | <Vardenafil, advise, alpha-blocker> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ritonavir and indinavir: Upon concomitant administration of 5 mg of Vardenafil with 600 mg BID ritonavir, the Cmax and AUC of ritonavir were reduced by approximately 20%. | <Vardenafil, mechanism, ritonavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Upon administration of 10 mg of Vardenafil with 800 mg TID indinavir, the Cmax and AUC of indinavir were reduced by 40% and 30%, respectively. | <Vardenafil, mechanism, indinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vitro studies have shown that the metabolism of docetaxel may be modified by the concomitant administration of compounds that induce, inhibit, or are metabolized by cytochrome P450 3A4, such as cyclosporine, terfenadine, ketoconazole, erythromycin, and troleandomycin. | <docetaxel, mechanism, cyclosporine>, <docetaxel, mechanism, terfenadine>, <docetaxel, mechanism, ketoconazole>, <docetaxel, mechanism, erythromycin>, <docetaxel, mechanism, troleandomycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid: As with other b-lactam antibiotics, renal excretion of loracarbef is inhibited by probenecid and resulted in an approximate 80% increase in the AUC for loracarbef. | <b-lactam antibiotics, mechanism, probenecid>, <loracarbef, mechanism, probenecid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients stabilized on oral anticoagulants who are found to require thyroid replacement therapy should be watched very closely when thyroid is started. | <anticoagulants, advise, thyroid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cholestyramine: Cholestyramine binds both T4 and T3 in the intestine, thus impairing absorption of these thyroid hormones. | <Cholestyramine, mechanism, T4>, <Cholestyramine, mechanism, T3> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, 4 to 5 hours should elapse between administration of cholestyramine and thyroid hormones. | <cholestyramine, advise, thyroid hormones> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a patient with a nonfunctioning thyroid gland who is receiving thyroid replacement therapy, free levothyroxine may be decreased when estrogens are started thus increasing thyroid requirements. | <levothyroxine, mechanism, estrogens> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, patients without a functioning thyroid gland who are on thyroid replacement therapy may need to increase their thyroid dose if estrogens or estrogen-containing oral contraceptives are given. | <thyroid, advise, estrogens>, <thyroid, advise, contraceptives> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Tricyclic Antidepressants: Use of thyroid products with imipramine and other tricyclic antidepressants may increase receptor sensitivity and enhance antidepressant activity transient cardiac arrhythmias have been observed. | <thyroid products, effect, imipramine>, <thyroid products, effect, tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digitalis: Thyroid preparations may potentiate the toxic effects of digitalis. | <Thyroid preparations, effect, digitalis> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Ketamine: When administered to patients on a thyroid preparation, this parenteral anesthetic may cause hypertension and tachycardia. | <thyroid preparation, effect, anesthetic> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Vasopressors: Thyroxine increases the adrenergic effect of catecholamines such as epinephrine and norepinephrine. | <Thyroxine, effect, epinephrine>, <Thyroxine, effect, norepinephrine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Results of preliminary studies in humans and rats suggest that nonabsorbable antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH. | <antacids, mechanism, lactulose> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity. | <FLUDARA, advise, pentostatin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anafranil should not be used with MAO inhibitors. | <Anafranil, advise, MAO inhibitors> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Close supervision and careful adjustment of dosage are required when Anafranil is administered with anticholinergic or sympathomimetic drugs. | <Anafranil, advise, anticholinergic>, <Anafranil, advise, sympathomimetic drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Several tricyclic antidepressants have been reported to block the pharmacologic effects of guanethidine, clonidine, or similar agents, and such an effect may be anticipated with CMI because of its structural similarity to other tricyclic antidepressants. | <tricyclic antidepressants, effect, guanethidine>, <tricyclic antidepressants, effect, clonidine>, <tricyclic antidepressants, effect, CMI>, <tricyclic antidepressants, effect, tricyclic antidepressants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The plasma concentration of CMI has been reported to be increased by the concomitant administration of haloperidol; | <CMI, mechanism, haloperidol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | plasma levels of several closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and such an effect may be anticipated with CMI as well. | <tricyclic antidepressants, mechanism, methylphenidate>, <tricyclic antidepressants, mechanism, cimetidine>, <tricyclic antidepressants, mechanism, fluoxetine>, <tricyclic antidepressants, mechanism, barbiturates>, <tricyclic antidepressants, mechanism, phenytoin>, <methylphenidate, mechanism, CMI>, <cimetidine, mechanism, CMI>, <fluoxetine, mechanism, CMI>, <barbiturates, mechanism, CMI>, <phenytoin, mechanism, CMI> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of CMI has been reported to increase the plasma levels of phenobarbital, if given concomitantly. | <CMI, mechanism, phenobarbital> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Fluvoxamine has also been shown to inhibit P450 1A2, an isoform also involved in TCAmetabolism. | <Fluvoxamine, mechanism, TCA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The extent to which SSRI-TCAinteractions may pose clinical problems will depend on the degree of inhibition and the pharmacokinetics of the SSRI involved. | <SSRI, int, TCA> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Nevertheless, caution is indicated in the co-administration of TCAs with any of the SSRIs and also in switching from one class to the other. | <TCAs, advise, SSRIs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Of particular importance, sufficient time must elapse before initiating TCAtreatment in a patient being withdrawn from fluoxetine, given the long half-life of the parent and active metabolite (at least 5 weeks may be necessary). | <TCA, advise, fluoxetine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because Anafranil is highly bound to serum protein, the administration of Anafranil to patients taking other drugs that are highly bound to protein (e.g., warfarin, digoxin) may cause an increase in plasma concentrations of these drugs, potentially resulting in adverse effects. | <Anafranil, mechanism, warfarin>, <Anafranil, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Digitalis toxicity may be aggravated by the initial release of norepinephrine caused by Bretylium Tosylate Injection. | <Digitalis, effect, Bretylium Tosylate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The pressor effects of catecholamines such as dopamine or norepinephrine are enhanced by Bretylium Tosylate. | <catecholamines, effect, Bretylium Tosylate>, <dopamine, effect, Bretylium Tosylate>, <norepinephrine, effect, Bretylium Tosylate> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Isoflurane potentiates the muscle relaxant effect of all muscle relaxants, most notably nondepolarizing muscle relaxants, and MAC (minimum alveolar concentration) is reduced by concomitant administration of N 2O. | <Isoflurane, effect, muscle relaxants>, <Isoflurane, effect, nondepolarizing muscle relaxants> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Barbiturates may decrease the effectiveness of oral contraceptives, certain antibiotics, quinidine, theophylline, corticosteroids, anticoagulants, and beta blockers. | <Barbiturates, effect, contraceptives>, <Barbiturates, effect, antibiotics>, <Barbiturates, effect, quinidine>, <Barbiturates, effect, theophylline>, <Barbiturates, effect, corticosteroids>, <Barbiturates, effect, anticoagulants>, <Barbiturates, effect, beta blockers> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients who have been treated with MAO inhibitors within two to three weeks prior to the administration of dopamine HCl should receive initial doses of dopamine HCl no greater than one-tenth (1/10) of the usual dose. | <MAO inhibitors, advise, dopamine HCl> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concurrent administration of low-dose dopamine HCl and diuretic agents may produce an additive or potentiating effect on urine flow. | <dopamine HCl, effect, diuretic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cardiac effects of dopamine are antagonized by beta-adrenergic blocking agents, such as propranolol and metoprolol. | <dopamine, effect, beta-adrenergic blocking agents>, <dopamine, effect, propranolol>, <dopamine, effect, metoprolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The peripheral vasoconstriction caused by high doses of dopamine HCl is antagonized by alpha-adrenergic blocking agents. | <dopamine HCl, effect, alpha-adrenergic blocking agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Butyrophenones (such as haloperidol) and phenothiazines can suppress the dopaminergic renal and mesenteric vasodilation induced with low dose dopamine infusion. | <Butyrophenones, effect, dopamine>, <haloperidol, effect, dopamine>, <phenothiazines, effect, dopamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Cyclopropane or halogenated hydrocarbon anesthetics increase cardiac autonomic irritability and may sensitize the myocardium to the action of certain intravenously administered catecholamines, such as dopamine. | <Cyclopropane, effect, catecholamines>, <Cyclopropane, effect, dopamine>, <halogenated hydrocarbon anesthetics, effect, catecholamines>, <halogenated hydrocarbon anesthetics, effect, dopamine> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, EXTREME CAUTION should be exercised when administering dopamine HCl to patients receiving cyclopropane or halogenated hydrocarbon anesthetics. | <dopamine HCl, advise, cyclopropane>, <dopamine HCl, advise, halogenated hydrocarbon anesthetics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It has been reported that results of studies in animals indicate that dopamine-induced ventricular arrhythmias during anesthesia can be reversed by propranolol. | <dopamine, effect, propranolol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant use of vasopressors, vasoconstricting agents (such as ergonovine) and some oxytocic drugs may result in severe hypertension. | <vasopressor, effect, oxytocic drugs>, <ergonovine, effect, oxytocic drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Administration of phenytoin to patients receiving dopamine HCl has been reported to lead to hypotension and bradycardia. | <phenytoin, effect, dopamine HCl> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is suggested that in patients receiving dopamine HCl, alternatives to phenytoin should be used if anticonvulsant therapy is needed. | <dopamine HCl, advise, phenytoin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The results of a study of coadministration of ethambutol (50 mg/kg) with an aluminum hydroxide containing antacid to 13 patients with tuberculosis showed a reduction of mean serum concentrations and urinary excretion of ethambutol of approximately 20% and 13%, respectively, suggesting that the oral absorption of ethambutol may be reduced by these antacid products. | <ethambutol, mechanism, aluminum hydroxide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended to avoid concurrent administration of ethambutol with aluminum hydroxide containing antacids for at least 4 hours following ethambutol administration. | <ethambutol, advise, aluminum hydroxide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Drug Interactions: The central anticholinergic syndrome can occur when anticholinergic agents such as AKINETON are administered concomitantly with drugs that have secondary anticholinergic actions, e.g., certain narcotic analgesics such as meperidine, the phenothiazines and other antipsychotics, tricyclic antidepressants, certain antiarrhythmics such as the quinidine salts, and antihistamines. | <anticholinergic, effect, narcotic analgesics>, <anticholinergic, effect, meperidine>, <anticholinergic, effect, phenothiazines>, <anticholinergic, effect, antipsychotics>, <anticholinergic, effect, tricyclic antidepressants>, <anticholinergic, effect, antiarrhythmics>, <anticholinergic, effect, quinidine>, <anticholinergic, effect, antihistamines>, <AKINETON, effect, narcotic analgesics>, <AKINETON, effect, meperidine>, <AKINETON, effect, phenothiazines>, <AKINETON, effect, antipsychotics>, <AKINETON, effect, tricyclic antidepressants>, <AKINETON, effect, antiarrhythmics>, <AKINETON, effect, quinidine>, <AKINETON, effect, antihistamines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant use of transdermal fentanyl with ritonavir or other potent 3A4 inhibitors such as ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, and nefazadone may result in an increase in fentanyl plasma concentrations. | <fentanyl, mechanism, ritonavir>, <fentanyl, mechanism, ketoconazole>, <fentanyl, mechanism, itraconazole>, <fentanyl, mechanism, troleandomycin>, <fentanyl, mechanism, clarithromycin>, <fentanyl, mechanism, nelfinavir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The concomitant use of other CYP3A4 inhibitors such as diltiazem and erythromycin with transdermal fentanyl may also result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause serious respiratory depression. | <diltiazem, mechanism, fentanyl>, <erythromycin, mechanism, fentanyl> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Central Nervous System Depressants: The concomitant use of DURAGESIC (fentanyl transdermal system) with other central nervous system depressants, including but not limited to other opioids, sedatives, hypnotics, tranquilizers (e.g., benzodiazepines), general anesthetics, phenothiazines, skeletal muscle relaxants, and alcohol, may cause respiratory depression, hypotension, and profound sedation, or potentially result in coma or death. | <DURAGESIC, effect, central nervous system depressants>, <DURAGESIC, effect, opioids>, <DURAGESIC, effect, sedatives>, <DURAGESIC, effect, hypnotics>, <DURAGESIC, effect, tranquilizers>, <DURAGESIC, effect, benzodiazepines>, <DURAGESIC, effect, anesthetics>, <DURAGESIC, effect, phenothiazines>, <DURAGESIC, effect, skeletal muscle relaxants>, <DURAGESIC, effect, alcohol>, <fentanyl, effect, central nervous system depressants>, <fentanyl, effect, opioids>, <fentanyl, effect, sedatives>, <fentanyl, effect, hypnotics>, <fentanyl, effect, tranquilizers>, <fentanyl, effect, benzodiazepines>, <fentanyl, effect, anesthetics>, <fentanyl, effect, phenothiazines>, <fentanyl, effect, skeletal muscle relaxants>, <fentanyl, effect, alcohol> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | MAO Inhibitors: DURAGESIC is not recommended for use in patients who have received MAOI within 14 days because severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics | <DURAGESIC, advise, MAOI>, <MAO inhibitors, advise, opioid analgesics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In vitro studies have shown CASODEX can displace coumarin anticoagulants, such as warfarin, from their protein-binding sites. | <CASODEX, mechanism, coumarin anticoagulant>, <CASODEX, mechanism, warfarin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is recommended that if CASODEX is started in patients already receiving coumarin anticoagulants, prothrombin times should be closely monitored and adjustment of the anticoagulant dose may be necessary. | <CASODEX, advise, coumarin anticoagulants>, <CASODEX, advise, anticoagulant> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors, tricyclic antidepressants or phenothiazines may produce severe, prolonged hypotension or hypertension. | <anesthetic solutions, effect, tricyclic antidepressants>, <anesthetic solutions, effect, phenothiazines>, <epinephrine, effect, monoamine oxidase inhibitors>, <epinephrine, effect, tricyclic antidepressants>, <epinephrine, effect, phenothiazines>, <norepinephrine, effect, monoamine oxidase inhibitors>, <norepinephrine, effect, tricyclic antidepressants>, <norepinephrine, effect, phenothiazines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents. | <vasopressor drugs, effect, ergot-type oxytocic drugs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, chloroprocaine should not be used in any condition in which a sulfonamide drug is being employed. | <chloroprocaine, advise, sulfonamide drug> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anticholinergic agents may affect gastrointestinal absorption of various drugs, such as slowly dissolving dosage forms of digoxin; | <Anticholinergic agents, mechanism, digoxin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Anticholinergic drugs may antagonize the effects of the drugs that alter gastrointestinal motility, such as metoclopramide. | <Anticholinergic drugs, mechanism, metoclopramide> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Because antacids may interfere with the absorption of anticholinergic agents, simultaneous use of these drugs should be avoided. | <antacids, mechanism, anticholinergic agents> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | In a study in which patients with active RA were treated for up to 24 weeks with concurrent ENBREL and anakinra therapy, a 7% rate of serious infections was observed, which was higher than that observed with ENBREL alone (0%). | <ENBREL, effect, anakinra> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Two percent of patients treated concurrently with ENBREL and anakinra developed neutropenia (ANC 1 x 109/L). | <ENBREL, effect, anakinra> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Patients in a clinical study who were on established therapy with sulfasalazine, to which ENBREL was added, were noted to develop a mild decrease in mean neutrophil counts in comparison to groups treated with either ENBREL CI or sulfasalazine alone. | <sulfasalazine, effect, ENBREL> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Caution should be exercised when administering nabumetone with warfarin since interactions have been seen with other NSAIDs. | <nabumetone, advise, warfarin>, <warfarin, int, NSAIDs> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Antacids (aluminum- or magnesium-containing): Concomitant administration of 300-mg cefdinir capsules with 30 mL Maalox TC suspension reduces the rate (Cmax) and extent (AUC) of absorption by approximately 40%. | <cefdinir, mechanism, Maalox TC> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If antacids are required during OMNICEF therapy, OMNICEF should be taken at least 2 hours before or after the antacid. | <OMNICEF, advise, antacid> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Probenecid: As with other b-lactam antibiotics, probenecid inhibits the renal excretion of cefdinir, resulting in an approximate doubling in A.C. a 54% increase in peak cefdinir plasma levels, and a 50% prolongation in the apparent elimination half-life. | <b-lactam antibiotics, mechanism, cefdinir>, <probenecid, mechanism, cefdinir> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Iron Supplements and Foods Fortified With Iron Concomitant administration of cefdinir with a therapeutic iron supplement containing 60 mg of elemental iron (as FeSO4) or vitamins supplemented with 10 mg of elemental iron reduced extent of absorption by 80% and 31%, respectively. | <cefdinir, mechanism, iron>, <cefdinir, mechanism, iron> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | If iron supplements are required during OMNICEF therapy, OMNICEF should be taken at least 2 hours before or after the supplement. | <iron supplements, advise, OMNICEF> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The reddish color is due to the formation of a nonabsorbable complex between cefdinir or its breakdown products and iron in the gastrointestinal tract. | <cefdinir, mechanism, iron> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Concurrent use of butorphanol with central nervous system depressants (e.g., alcohol, barbiturates, tranquilizers, and antihistamines) may result in increased central nervous system depressant effects. | <butorphanol, effect, central nervous system depressants>, <butorphanol, effect, alcohol>, <butorphanol, effect, barbiturates>, <butorphanol, effect, tranquilizers>, <butorphanol, effect, antihistamines> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, in another study in healthy volunteers, the pharmacokinetics of butorphanol were significantly altered (29% decrease in AUC and 38% decrease in Cmax) when a 1-mg dose of STADOL NS was administered 1 minute after a 20-mg dose of sumatriptan nasal spray. | <STADOL NS, mechanism, sumatriptan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | When the STADOL NS was administered 30 minutes after the sumatriptan nasal spray, the AUC of butorphanol increased 11% and Cmax decreased 18%. | <STADOL NS, mechanism, sumatriptan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | These results suggest that the analgesic effect of STADOL NS may be diminished when it is administered shortly after sumatriptan nasal spray, but by 30 minutes any such reduction in effect should be minimal. | <STADOL NS, effect, sumatriptan> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | It is not known if the effects of butorphanol are altered by concomitant medications that affect hepatic metabolism of drugs (erythromycin, etc.), but physicians should be alert to the possibility that a smaller initial dose and longer intervals between doses may be needed. | <butorphanol, advise, erythromycin> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Therefore, a slower onset can be anticipated if STADOL NS is administered concomitantly with, or immediately following, a nasal vasoconstrictor. | <STADOL NS, effect, nasal vasoconstrictor> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Hypotension: Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with enalapril or enalaprilat. | <diuretics, effect, enalapril>, <diuretics, effect, enalaprilat> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | The possibility of hypotensive effects with enalapril or enalaprilat can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with enalapril or enalaprilat. | <enalapril, effect, diuretic>, <enalaprilat, effect, diuretic> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Agents Causing Renin Release: The antihypertensive effect of enalapril and enalapril IV is augmented by antihypertensive agents that cause renin release (e.g., diuretics). | <enalapril, effect, antihypertensive agents>, <enalapril, effect, diuretics>, <enalapril, effect, antihypertensive agents>, <enalapril, effect, diuretics> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | Non-steroidal Anti-inflammatory Agents: In some patients with compromised renal function who are being treated with nonsteroidal anti-inflammatory drugs, the co-administration of enalapril may result in a further deterioration of renal function. | <nonsteroidal anti-inflammatory drugs, effect, enalapril> |
Extract drug entities and inter-entity relationships from sentences and output them in the form of triplets. | However, reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors. | <NSAIDs, effect, ACE inhibitors> |