Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC9429973
Image: Summary/Conclusion: The rate of reconstitution and the acquisition of an alloreactive phenotype by NK depends on the variant of T-cell depletion; faster recovery occurs when performing haplo-HSCT with TCRαβ-depletion.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclusion", ":", "The", "rate", "of", "reconstitution", "and", "the", "acquisition", "of", "an", "alloreactive", "phenotype", "by", "NK", "depends", "on", "the", "variant", "of", "T-cell", "depletion", ";", "faster", "recovery", "occurs", "when", "performing", "haplo-HSCT", "with", "TCRαβ-depletion", "." ] } ]
PMC11757230
In contrast, some studies have reported that MSCs inhibit the migration and invasion of breast cancer cells via secretion of tissue inhibitors of metalloproteinase (TIMP)-1 and -2 , and colorectal cancer cells via exosome-derived microRNA-4461 .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "some", "studies", "have", "reported", "that", "MSCs", "inhibit", "the", "migration", "and", "invasion", "of", "breast", "cancer", "cells", "via", "secretion", "of", "tissue", "inhibitors", "of", "metalloproteinase", "(TIMP)-1", "and", "-2", ",", "and", "colorectal", "cancer", "cells", "via", "exosome-derived", "microRNA-4461", "." ] } ]
PMC9429973
Summary/Conclusion: CPX-351 is active in young pts with t-AML and AML-MRC with an ORR higher than that reported in the pivotal study (78% vs 47%) and high rate of bridge to transplant at first remission (56%) also considering the different age range.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "CPX-351", "is", "active", "in", "young", "pts", "with", "t-AML", "and", "AML-MRC", "with", "an", "ORR", "higher", "than", "that", "reported", "in", "the", "pivotal", "study", "(", "78", "%", "vs", "47", "%", ")", "and", "high", "rate", "of", "bridge", "to", "transplant", "at", "first", "remission", "(", "56", "%", ")", "also", "considering", "the", "different", "age", "range", "." ] } ]
PMC11476837
Since oxidative stress imbalance is implicated in cancer cell resistance, we took a closer look at the intracellular ROS level in doxorubicin-treated HL-60/DR cells in combination with NRF2 inhibitors.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "oxidative", "stress", "imbalance", "is", "implicated", "in", "cancer", "cell", "resistance", ",", "we", "took", "a", "closer", "look", "at", "the", "intracellular", "ROS", "level", "in", "doxorubicin-treated", "HL-60/DR", "cells", "in", "combination", "with", "NRF2", "inhibitors", "." ] } ]
PMC10291556
Clinically apparent tumors evolve mechanisms to evade immune elimination.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinically", "apparent", "tumors", "evolve", "mechanisms", "to", "evade", "immune", "elimination", "." ] } ]
PMC11706297
The main goals of the current work were to combine naphthalene with the pyrazoline–thiazole framework and determine the potential anticancer effects of this combination against breast cancer and NSCLC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "main", "goals", "of", "the", "current", "work", "were", "to", "combine", "naphthalene", "with", "the", "pyrazoline", "–", "thiazole", "framework", "and", "determine", "the", "potential", "anticancer", "effects", "of", "this", "combination", "against", "breast", "cancer", "and", "NSCLC", "." ] } ]
PMC9429973
Subacute form of cardiotoxicity occurred in 11/13 patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subacute", "form", "of", "cardiotoxicity", "occurred", "in", "11/13", "patients", "." ] } ]
PMC10999934
Crucially, the findings from the enrichment analysis were supported by another scRNA-seq dataset GSE154600, demonstrating the participation of epithelial cells in chemoresistance of HGSOC.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "Crucially", ",", "the", "findings", "from", "the", "enrichment", "analysis", "were", "supported", "by", "another", "scRNA-seq", "dataset", "GSE154600", ",", "demonstrating", "the", "participation", "of", "epithelial", "cells", "in", "chemoresistance", "of", "HGSOC", "." ] } ]
PMC11792888
p < 0.05 compared to control (the culture media in absence of scorpion venom) from Kruskal-Wallis non-parametric test.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", "compared", "to", "control", "(", "the", "culture", "media", "in", "absence", "of", "scorpion", "venom", ")", "from", "Kruskal-Wallis", "non-parametric", "test", "." ] } ]
PMC11588008
However, this study has some limitations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "this", "study", "has", "some", "limitations", "." ] } ]
PMC8777939
The IHC assay revealed that the combination treatment mostly eliminated the positive PCNA-stained cells compared to the control group and etravirine group (Figure 6h).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IHC", "assay", "revealed", "that", "the", "combination", "treatment", "mostly", "eliminated", "the", "positive", "PCNA-stained", "cells", "compared", "to", "the", "control", "group", "and", "etravirine", "group", "(", "Figure", "6h", ")", "." ] } ]
PMC11792888
However, only a few have compared the cancer cell phenotype with its normal cell counterpart.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "only", "a", "few", "have", "compared", "the", "cancer", "cell", "phenotype", "with", "its", "normal", "cell", "counterpart", "." ] } ]
PMC11684269
Recent studies have increasingly targeted immunometabolism, aiming to regulate immune response via cellular metabolic modulation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "increasingly", "targeted", "immunometabolism", ",", "aiming", "to", "regulate", "immune", "response", "via", "cellular", "metabolic", "modulation", "." ] } ]
PMC11706776
Of note, the relatively small number of patients made it impossible to associate SK1 expression levels with patients’ clinical data.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note", ",", "the", "relatively", "small", "number", "of", "patients", "made", "it", "impossible", "to", "associate", "SK1", "expression", "levels", "with", "patients", "’", "clinical", "data", "." ] } ]
PMC11467800
Although K562‐IR cells exhibit some leukaemic stem cell‐like properties, they, like their parental K562 cells, are CD34 negative.
[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "K562‐IR", "cells", "exhibit", "some", "leukaemic", "stem", "cell‐like", "properties", ",", "they", ",", "like", "their", "parental", "K562", "cells", ",", "are", "CD34", "negative", "." ] } ]
PMC11612315
The exendin 20–29 alanine scanning library was purchased from GenScript (Piscataway, NJ).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exendin", "20–29", "alanine", "scanning", "library", "was", "purchased", "from", "GenScript", "(", "Piscataway", ",", "NJ", ")", "." ] } ]
PMC8992508
These compounds showed no inhibitory activity toward P-gp and MRP1 thus proving to be highly BCRP selective.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "compounds", "showed", "no", "inhibitory", "activity", "toward", "P-gp", "and", "MRP1", "thus", "proving", "to", "be", "highly", "BCRP", "selective", "." ] } ]
PMC9895440
To investigate the dependency on CD28 signaling in vivo, we used a 4-1BB domain-containing anti-CD19 CAR and additionally knocked out the endogenous CD28 (“CART19-BBz CD28 KO”, Supplementary Fig. 10d).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "investigate", "the", "dependency", "on", "CD28", "signaling", "in", "vivo", ",", "we", "used", "a", "4", "-", "1BB", "domain-containing", "anti-CD19", "CAR", "and", "additionally", "knocked", "out", "the", "endogenous", "CD28", "(", "“", "CART19-BBz", "CD28", "KO", "”", ",", "Supplementary", "Fig.", "10d", ")", "." ] } ]
PMC6642070
Chromatin from A-204 cells was immunoprecipitated (IP) with either anti-p53 antibody or control IgG. The obtained DNA fragments were amplified by PCR using a set of primer pairs surrounding the p53RRE sites in the ENO3 promoter.
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chromatin", "from", "A-204", "cells", "was", "immunoprecipitated", "(", "IP", ")", "with", "either", "anti-p53", "antibody", "or", "control", "IgG.", "The", "obtained", "DNA", "fragments", "were", "amplified", "by", "PCR", "using", "a", "set", "of", "primer", "pairs", "surrounding", "the", "p53RRE", "sites", "in", "the", "ENO3", "promoter", "." ] } ]
PMC9429973
Methods: Prospective, observational, multicenter study including adult p. who initiated TPO-RA with persistent (pITP) or chronic (cITP) ITP.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Prospective", ",", "observational", ",", "multicenter", "study", "including", "adult", "p.", "who", "initiated", "TPO-RA", "with", "persistent", "(", "pITP", ")", "or", "chronic", "(", "cITP", ")", "ITP", "." ] } ]
PMC11789597
Error bar, mean ± SD. ,
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Error", "bar", ",", "mean", "±", "SD", ".", "," ] } ]
PMC11704834
To generate mechanistic insights on the upregulation of TLE1 expression during the development of EGFR-TKI resistance, the promoter region of TLE1 was examined for binding sites for TFs that are associated with EGFR-TKI resistance in human lung cancer cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "generate", "mechanistic", "insights", "on", "the", "upregulation", "of", "TLE1", "expression", "during", "the", "development", "of", "EGFR-TKI", "resistance", ",", "the", "promoter", "region", "of", "TLE1", "was", "examined", "for", "binding", "sites", "for", "TFs", "that", "are", "associated", "with", "EGFR-TKI", "resistance", "in", "human", "lung", "cancer", "cells", "." ] } ]
PMC9429973
Drug-related TEAEs were liver injury and hyponatremia (8% each).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drug-related", "TEAEs", "were", "liver", "injury", "and", "hyponatremia", "(", "8", "%", "each", ")", "." ] } ]
PMC8193046
The slope values from the linear fluorescence increase revealed the effect value which has been normalized to the effect value of 10 µM of either compounds 2 (ABCB1) or 26 (ABCC1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "slope", "values", "from", "the", "linear", "fluorescence", "increase", "revealed", "the", "effect", "value", "which", "has", "been", "normalized", "to", "the", "effect", "value", "of", "10", "µM", "of", "either", "compounds", "2", "(", "ABCB1", ")", "or", "26", "(", "ABCC1", ")", "." ] } ]
PMC8494202
Although we made every effort to elucidate the relationship between CKAP2L and the prognosis of glioma patients, the use of public databases has certain limitations, such as inconsistent clinical information across different databases.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "we", "made", "every", "effort", "to", "elucidate", "the", "relationship", "between", "CKAP2L", "and", "the", "prognosis", "of", "glioma", "patients", ",", "the", "use", "of", "public", "databases", "has", "certain", "limitations", ",", "such", "as", "inconsistent", "clinical", "information", "across", "different", "databases", "." ] } ]
PMC11731161
There is a positive correlation between XPO1 degradation and sensitivity to SEL in these cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "a", "positive", "correlation", "between", "XPO1", "degradation", "and", "sensitivity", "to", "SEL", "in", "these", "cells", "." ] } ]
PMC6222726
Boswellia and Commiphora are present in desert parts of tropical Africa, Arabia, Pakistan, and India, whereas Bursera is distributed from the Southern U.S. to Peru and the Caribbean, and particularly in Mexico.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Boswellia", "and", "Commiphora", "are", "present", "in", "desert", "parts", "of", "tropical", "Africa", ",", "Arabia", ",", "Pakistan", ",", "and", "India", ",", "whereas", "Bursera", "is", "distributed", "from", "the", "Southern", "U.S.", "to", "Peru", "and", "the", "Caribbean", ",", "and", "particularly", "in", "Mexico", "." ] } ]
PMC10745221
Additionally, histone lysine methylation differed between the 143B-P and 143B-R cells, so we expected changes specifically in histone arginine methylation .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "histone", "lysine", "methylation", "differed", "between", "the", "143B-P", "and", "143B-R", "cells", ",", "so", "we", "expected", "changes", "specifically", "in", "histone", "arginine", "methylation", "." ] } ]
PMC11529598
These findings show that miR-3154 promotes glioblastoma proliferation and metastasis via targeting TP53INP1.Glioblastomas (GBM) are the most common types of primary brain tumors .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "show", "that", "miR-3154", "promotes", "glioblastoma", "proliferation", "and", "metastasis", "via", "targeting", "TP53INP1.Glioblastomas", "(", "GBM", ")", "are", "the", "most", "common", "types", "of", "primary", "brain", "tumors", "." ] } ]
PMC9429973
Methods: Observational, retrospective, cross-sectional and analytical.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Observational", ",", "retrospective", ",", "cross-sectional", "and", "analytical", "." ] } ]
PMC11748363
The combined organic layers were dried over anhydrous sodium sulfate, filtered, and subjected to the purification process described below (Section Purification).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combined", "organic", "layers", "were", "dried", "over", "anhydrous", "sodium", "sulfate", ",", "filtered", ",", "and", "subjected", "to", "the", "purification", "process", "described", "below", "(", "Section", "Purification", ")", "." ] } ]
PMC7504302
Of note, the depletion of WEE1, a G2-M checkpoint kinase with therapeutic implications, showed the most remarkable negative effect on cell viability.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note", ",", "the", "depletion", "of", "WEE1", ",", "a", "G2-M", "checkpoint", "kinase", "with", "therapeutic", "implications", ",", "showed", "the", "most", "remarkable", "negative", "effect", "on", "cell", "viability", "." ] } ]
PMC10858941
The image on the right shows a microdevice as seen through the fluorescence microscope [2x].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "image", "on", "the", "right", "shows", "a", "microdevice", "as", "seen", "through", "the", "fluorescence", "microscope", "[", "2x", "]", "." ] } ]
PMC6222635
From the results, the mannose content in F1 to F6 was larger than the content in D1 to D6.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "the", "results", ",", "the", "mannose", "content", "in", "F1", "to", "F6", "was", "larger", "than", "the", "content", "in", "D1", "to", "D6", "." ] } ]
PMC10994876
Apoptotic cells were detected using annexin V-PE and 7-AAD flow cytometry, and the results were reported as the mean ± SD of apoptotic cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptotic", "cells", "were", "detected", "using", "annexin", "V-PE", "and", "7-AAD", "flow", "cytometry", ",", "and", "the", "results", "were", "reported", "as", "the", "mean", "±", "SD", "of", "apoptotic", "cells", "." ] } ]
PMC10747139
The anticancer activity effects were examined against a human umbilical vein cell line, EA.hy926, using an MTT test.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anticancer", "activity", "effects", "were", "examined", "against", "a", "human", "umbilical", "vein", "cell", "line", ",", "EA.hy926", ",", "using", "an", "MTT", "test", "." ] } ]
PMC11472639
Therefore, it is important to consider that exercising patients with myeloma during daratumumab treatment could result in greater overall NK-cell reductions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "it", "is", "important", "to", "consider", "that", "exercising", "patients", "with", "myeloma", "during", "daratumumab", "treatment", "could", "result", "in", "greater", "overall", "NK-cell", "reductions", "." ] } ]
PMC9429973
The primary efficacy endpoint was ORR as assessed by independent review using the Lugano criteria and analyzed 6 months after completing enrollment in the PEP.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "efficacy", "endpoint", "was", "ORR", "as", "assessed", "by", "independent", "review", "using", "the", "Lugano", "criteria", "and", "analyzed", "6", "months", "after", "completing", "enrollment", "in", "the", "PEP", "." ] } ]
PMC6364197
These results demonstrated that 3D culture enhances chemoresistance of ALL Jurkat cell line by increasing DDR1 expression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "demonstrated", "that", "3D", "culture", "enhances", "chemoresistance", "of", "ALL", "Jurkat", "cell", "line", "by", "increasing", "DDR1", "expression", "." ] } ]
PMC9503541
Therefore, there is a higher possibility of obtaining biologically relevant results when PCA scores are guided by PLS classification.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "there", "is", "a", "higher", "possibility", "of", "obtaining", "biologically", "relevant", "results", "when", "PCA", "scores", "are", "guided", "by", "PLS", "classification", "." ] } ]
PMC11795610
Immunofluorescence staining of TRPV4, 200 magnification, scale bars = 50 μm. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunofluorescence", "staining", "of", "TRPV4", ",", "200", "magnification", ",", "scale", "bars", "=", "50", "μm", ".", "(" ] } ]
PMC11555465
Toxoplasma gondii is an opportunistic protozoan parasite that can infect warm-blooded animals, birds and humans (6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Toxoplasma", "gondii", "is", "an", "opportunistic", "protozoan", "parasite", "that", "can", "infect", "warm-blooded", "animals", ",", "birds", "and", "humans", "(", "6", ")", "." ] } ]
PMC10291556
The centricon was then turned upside down, and the high molecular mass fraction was collected into an Eppendorf tube.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "centricon", "was", "then", "turned", "upside", "down", ",", "and", "the", "high", "molecular", "mass", "fraction", "was", "collected", "into", "an", "Eppendorf", "tube", "." ] } ]
PMC11394730
In cancer cells, the cell cycle is highly disrupted and irregular.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "cancer", "cells", ",", "the", "cell", "cycle", "is", "highly", "disrupted", "and", "irregular", "." ] } ]
PMC9910796
Mock (M) and ASFV-infected cells incubated for 15 h in the presence of DNA synthesis inhibitor ara-C were also analyzed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mock", "(", "M", ")", "and", "ASFV-infected", "cells", "incubated", "for", "15", "h", "in", "the", "presence", "of", "DNA", "synthesis", "inhibitor", "ara-C", "were", "also", "analyzed", "." ] } ]
PMC8956657
B Comparison view of the well-characterized SV40 T-ag NLS bound to IMPα, showing a well-characterized Lys at the P2 site.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Comparison", "view", "of", "the", "well-characterized", "SV40", "T-ag", "NLS", "bound", "to", "IMPα", ",", "showing", "a", "well-characterized", "Lys", "at", "the", "P2", "site", "." ] } ]
PMC9096373
Then, DAB substrate solution was added, the samples were incubated at room temperature for 5–20 minutes, and observed using optical microscopy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "DAB", "substrate", "solution", "was", "added", ",", "the", "samples", "were", "incubated", "at", "room", "temperature", "for", "5–20", "minutes", ",", "and", "observed", "using", "optical", "microscopy", "." ] } ]
PMC11514418
On days 1-7 of the chemotherapy cycle, APS injection (250 mg) was added to 500 mL of saline solution for intravenous infusion once a day following the drug instruction.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "days", "1", "-", "7", "of", "the", "chemotherapy", "cycle", ",", "APS", "injection", "(", "250", "mg", ")", "was", "added", "to", "500", "mL", "of", "saline", "solution", "for", "intravenous", "infusion", "once", "a", "day", "following", "the", "drug", "instruction", "." ] } ]
PMC7351993
First, the throughput can simply be boosted by increasing the flow speed of cells, but this comes at the expense of imaging sensitivity and the number of pixels in the flow direction.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "the", "throughput", "can", "simply", "be", "boosted", "by", "increasing", "the", "flow", "speed", "of", "cells", ",", "but", "this", "comes", "at", "the", "expense", "of", "imaging", "sensitivity", "and", "the", "number", "of", "pixels", "in", "the", "flow", "direction", "." ] } ]
PMC11451829
On day 1 (Fig. 1A) after subconjunctival injection, the eyes showed a normal conjunctiva, characterized by a flat, smooth appearance and the absence of hyperemia.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "day", "1", "(", "Fig.", "1A", ")", "after", "subconjunctival", "injection", ",", "the", "eyes", "showed", "a", "normal", "conjunctiva", ",", "characterized", "by", "a", "flat", ",", "smooth", "appearance", "and", "the", "absence", "of", "hyperemia", "." ] } ]
PMC10938336
The tested compounds were dissolved in ethanol and DMSO, and successive dilutions of the compounds were made.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tested", "compounds", "were", "dissolved", "in", "ethanol", "and", "DMSO", ",", "and", "successive", "dilutions", "of", "the", "compounds", "were", "made", "." ] } ]
PMC9684669
To further investigate the potential targets and mechanisms of drug resistance, we used RNA-seq to assess the transcriptional differences between A2780 and A2780-ADR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O" ], "tokens": [ "To", "further", "investigate", "the", "potential", "targets", "and", "mechanisms", "of", "drug", "resistance", ",", "we", "used", "RNA-seq", "to", "assess", "the", "transcriptional", "differences", "between", "A2780", "and", "A2780-ADR", "." ] } ]
PMC10818573
To more accurately compare the difference between PCR analysis and the RPA-LFA method in detecting EBV, we used the same sample types for RPA-LFA amplification.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "more", "accurately", "compare", "the", "difference", "between", "PCR", "analysis", "and", "the", "RPA-LFA", "method", "in", "detecting", "EBV", ",", "we", "used", "the", "same", "sample", "types", "for", "RPA-LFA", "amplification", "." ] } ]
PMC9429973
The revised (R-IPI) and enhanced (NCCN-IPI) indices have emerged to improve prognostic ability.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "revised", "(", "R-IPI", ")", "and", "enhanced", "(", "NCCN-IPI", ")", "indices", "have", "emerged", "to", "improve", "prognostic", "ability", "." ] } ]
PMC11805741
The molecular docking results for the interaction between the BCL-2 protein and the ligand zeaxanthin indicate a strong binding affinity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "molecular", "docking", "results", "for", "the", "interaction", "between", "the", "BCL-2", "protein", "and", "the", "ligand", "zeaxanthin", "indicate", "a", "strong", "binding", "affinity", "." ] } ]
PMC11764090
NAC (NAM, ATAF1/2, CUC2) is one of the largest families of transcription factors endemic to plants .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NAC", "(", "NAM", ",", "ATAF1/2", ",", "CUC2", ")", "is", "one", "of", "the", "largest", "families", "of", "transcription", "factors", "endemic", "to", "plants", "." ] } ]
PMC11401350
T cells were surface stained for CD8 and hCD34, CD44 and CD62L.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T", "cells", "were", "surface", "stained", "for", "CD8", "and", "hCD34", ",", "CD44", "and", "CD62L", "." ] } ]
PMC11387401
One hypothesis is that Tat, in complex with P-TEFb, binds the mRNAs of these factors in a feed-forward loop to enhance their transcription and HIV-1 transcription elongation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "hypothesis", "is", "that", "Tat", ",", "in", "complex", "with", "P-TEFb", ",", "binds", "the", "mRNAs", "of", "these", "factors", "in", "a", "feed-forward", "loop", "to", "enhance", "their", "transcription", "and", "HIV-1", "transcription", "elongation", "." ] } ]
PMC11591794
For this reason, interest in new active ingredients obtained from natural products is increasing.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", "reason", ",", "interest", "in", "new", "active", "ingredients", "obtained", "from", "natural", "products", "is", "increasing", "." ] } ]
PMC11594074
The DNMT1 activity was calculated using the following formula:(1)Inhibition %=1−(Inhibitor Sample OD−BLank ODNo Inhibitor Control OD−Blank OD)×100% The cytotoxicity of the top compounds was determined in vitro using the resazurin reduction assay following the protocol described as follows: The cell lines HCT116 and MDA-MB-468 grow adherently and were therefore seeded and incubated in 96-well plates (1 × 10 cells/well) for 24 h prior to treatment, allowing attachment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "DNMT1", "activity", "was", "calculated", "using", "the", "following", "formula:(1)Inhibition", "%", "=", "1−(Inhibitor", "Sample", "OD−BLank", "ODNo", "Inhibitor", "Control", "OD−Blank", "OD)", "×", "100", "%", "The", "cytotoxicity", "of", "the", "top", "compounds", "was", "determined", "in", "vitro", "using", "the", "resazurin", "reduction", "assay", "following", "the", "protocol", "described", "as", "follows", ":", "The", "cell", "lines", "HCT116", "and", "MDA-MB-468", "grow", "adherently", "and", "were", "therefore", "seeded", "and", "incubated", "in", "96-well", "plates", "(", "1", "×", "10", "cells/well", ")", "for", "24", "h", "prior", "to", "treatment", ",", "allowing", "attachment", "." ] } ]
PMC10529414
PLKO.1 EV sh-Ctrl was used as a control plasmid (4.275 µg/µL).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLKO.1", "EV", "sh-Ctrl", "was", "used", "as", "a", "control", "plasmid", "(", "4.275", "µg/µL", ")", "." ] } ]
PMC11218145
Quantifications of basal (Basal OCR) and ATP-related respiration rates (ATP-OCR) were calculated from OCR traces TB modulates the mitochondrial metabolism.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantifications", "of", "basal", "(", "Basal", "OCR", ")", "and", "ATP-related", "respiration", "rates", "(", "ATP-OCR", ")", "were", "calculated", "from", "OCR", "traces", "TB", "modulates", "the", "mitochondrial", "metabolism", "." ] } ]
PMC11406030
The manufacturer’s protocol and calculation were followed for both kits.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "manufacturer", "’s", "protocol", "and", "calculation", "were", "followed", "for", "both", "kits", "." ] } ]
PMC11719944
Informed consent was obtained from all patients and healthy donors.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Informed", "consent", "was", "obtained", "from", "all", "patients", "and", "healthy", "donors", "." ] } ]
PMC9429973
ASTX727 (DEC-C) is a fixed dose combination (FDC) tablet of 35 mg DEC and 100 mg cedazuridine, a novel cytidine deaminase inhibitor (CDAi).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ASTX727", "(", "DEC-C", ")", "is", "a", "fixed", "dose", "combination", "(", "FDC", ")", "tablet", "of", "35", "mg", "DEC", "and", "100", "mg", "cedazuridine", ",", "a", "novel", "cytidine", "deaminase", "inhibitor", "(", "CDAi", ")", "." ] } ]
PMC11529598
B. Migration ability of miR-3154 sponge A172 cells and control A172 cells was measured using Transwell assay. *
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B.", "Migration", "ability", "of", "miR-3154", "sponge", "A172", "cells", "and", "control", "A172", "cells", "was", "measured", "using", "Transwell", "assay", ".", "*" ] } ]
PMC7812570
A Western blot assay with an anti-His tag antibody found that Sec-m36.4 and Sec-FluIgG03 were detected only in the highly concentrated cell culture supernatants, not in the cell lysates (Supplementary Fig. S2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Western", "blot", "assay", "with", "an", "anti-His", "tag", "antibody", "found", "that", "Sec-m36.4", "and", "Sec-FluIgG03", "were", "detected", "only", "in", "the", "highly", "concentrated", "cell", "culture", "supernatants", ",", "not", "in", "the", "cell", "lysates", "(", "Supplementary", "Fig.", "S2", ")", "." ] } ]
PMC6803987
Data were expressed as means ± standard deviation (S.D.).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "expressed", "as", "means", "±", "standard", "deviation", "(", "S.D.", ")", "." ] } ]
PMC5308810
CXCR4-KLA, (KPVSLSYRCGGKLAKLAKKLAKLAK), and its FITC-labeled analogue were synthesized on a PS3 peptide synthesizer (Protein Technologies, Tucson, AZ), employing the Fmoc strategy on rink amide .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CXCR4-KLA", ",", "(", "KPVSLSYRCGGKLAKLAKKLAKLAK", ")", ",", "and", "its", "FITC-labeled", "analogue", "were", "synthesized", "on", "a", "PS3", "peptide", "synthesizer", "(", "Protein", "Technologies", ",", "Tucson", ",", "AZ", ")", ",", "employing", "the", "Fmoc", "strategy", "on", "rink", "amide", "." ] } ]
PMC11555465
Compared with that in the control group, the apoptosis rate was higher in the RH and ToxoDB#9 experimental groups, which indicated that the culture supernatant of T. gondii tachyzoite promoted the apoptosis of bladder cancer 5637 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Compared", "with", "that", "in", "the", "control", "group", ",", "the", "apoptosis", "rate", "was", "higher", "in", "the", "RH", "and", "ToxoDB#9", "experimental", "groups", ",", "which", "indicated", "that", "the", "culture", "supernatant", "of", "T.", "gondii", "tachyzoite", "promoted", "the", "apoptosis", "of", "bladder", "cancer", "5637", "cells", "." ] } ]
PMC9429973
Z. Zhuang, Y. Tian, H. Yu, L. Shi, W.-W. Tian, Q. Liu, D. Zou, F. Dong, Y. Ma, R. Feng, S. Liu, H. Liu, H. Jing, W. Sun, L.-M. Ma, L. Bao, R. Fu, Y. Wu, W. Chen, J. Zhuang Department of Hematology, Peking Union Medical College Hospital; Department of Hematology, Beijing Chao-Yang Hospital of Capital Medical University, Beijing; Department of Hematology, Tianjin Medical University General Hospital, Tianjin; Department of Hematology, Beijing JishuitanHospital, Beijing; Department of Hematology, Shanxi Bethune Hospital of Shanxi Medical University, Taiyuan; Department of Hematology, The First Affiliated Hospital of Anhui Medical University, Hefei; Department of Hematology, Xuanwu Hospital of Capital Medical University; Department of Hematology, Peking University Third Hospital, Beijing; Department of Hematology, The second Hospital of Shanxi Medical University, Taiyuan; Department of Hematology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing, China Background: Maintenance therapy (MT) deepens response and prolongs progression free survival (PFS) in patients with newly diagnosed multiple myeloma (NDMM) after frontline regimens.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Z.", "Zhuang", ",", "Y.", "Tian", ",", "H.", "Yu", ",", "L.", "Shi", ",", "W.-W.", "Tian", ",", "Q.", "Liu", ",", "D.", "Zou", ",", "F.", "Dong", ",", "Y.", "Ma", ",", "R.", "Feng", ",", "S.", "Liu", ",", "H.", "Liu", ",", "H.", "Jing", ",", "W.", "Sun", ",", "L.-M.", "Ma", ",", "L.", "Bao", ",", "R.", "Fu", ",", "Y.", "Wu", ",", "W.", "Chen", ",", "J.", "Zhuang", "Department", "of", "Hematology", ",", "Peking", "Union", "Medical", "College", "Hospital", ";", "Department", "of", "Hematology", ",", "Beijing", "Chao-Yang", "Hospital", "of", "Capital", "Medical", "University", ",", "Beijing", ";", "Department", "of", "Hematology", ",", "Tianjin", "Medical", "University", "General", "Hospital", ",", "Tianjin", ";", "Department", "of", "Hematology", ",", "Beijing", "JishuitanHospital", ",", "Beijing", ";", "Department", "of", "Hematology", ",", "Shanxi", "Bethune", "Hospital", "of", "Shanxi", "Medical", "University", ",", "Taiyuan", ";", "Department", "of", "Hematology", ",", "The", "First", "Affiliated", "Hospital", "of", "Anhui", "Medical", "University", ",", "Hefei", ";", "Department", "of", "Hematology", ",", "Xuanwu", "Hospital", "of", "Capital", "Medical", "University", ";", "Department", "of", "Hematology", ",", "Peking", "University", "Third", "Hospital", ",", "Beijing", ";", "Department", "of", "Hematology", ",", "The", "second", "Hospital", "of", "Shanxi", "Medical", "University", ",", "Taiyuan", ";", "Department", "of", "Hematology", ",", "Beijing", "Hospital", ",", "National", "Center", "of", "Gerontology", ",", "Institute", "of", "Geriatric", "Medicine", ",", "Chinese", "Academy", "of", "Medical", "Science", ",", "Beijing", ",", "China", "Background", ":", "Maintenance", "therapy", "(", "MT", ")", "deepens", "response", "and", "prolongs", "progression", "free", "survival", "(", "PFS", ")", "in", "patients", "with", "newly", "diagnosed", "multiple", "myeloma", "(", "NDMM", ")", "after", "frontline", "regimens", "." ] } ]
PMC11761919
Exploring whether phthalyl inulin nanoparticles can promote the proliferation of recombinant probiotics and improve heterologous protein expression levels in probiotics is worthwhile.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exploring", "whether", "phthalyl", "inulin", "nanoparticles", "can", "promote", "the", "proliferation", "of", "recombinant", "probiotics", "and", "improve", "heterologous", "protein", "expression", "levels", "in", "probiotics", "is", "worthwhile", "." ] } ]
PMC10993311
Singular value decomposition (SVD) analysis was applied to beta-values to correlate biological covariates with the principal components, as described by Argentato et al. (2023), which led to the identification of 11 DMRs between EGWG and AGWG (DMR1 = chr6:29648161-29648756, DMR2 = chr6:31148332-31148666, DMR3 = chr7:27183133-27183816, DMR4 = chr10:530635-531584, DMR5 = chr22:51016386-51016950, DMR6 = chr16:3062296-3062975, DMR7 = chr5:110062539-110062837, DMR8 = chr17:41278135-41278906, DMR9 = chr2:27301195-27301943, DMR10 = chr5:170288671-170288788, DMR11 = chr12:52281482-52281997) were identified.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Singular", "value", "decomposition", "(", "SVD", ")", "analysis", "was", "applied", "to", "beta-values", "to", "correlate", "biological", "covariates", "with", "the", "principal", "components", ",", "as", "described", "by", "Argentato", "et", "al.", "(", "2023", ")", ",", "which", "led", "to", "the", "identification", "of", "11", "DMRs", "between", "EGWG", "and", "AGWG", "(", "DMR1", "=", "chr6:29648161", "-", "29648756", ",", "DMR2", "=", "chr6:31148332", "-", "31148666", ",", "DMR3", "=", "chr7:27183133", "-", "27183816", ",", "DMR4", "=", "chr10:530635", "-", "531584", ",", "DMR5", "=", "chr22:51016386", "-", "51016950", ",", "DMR6", "=", "chr16:3062296", "-", "3062975", ",", "DMR7", "=", "chr5:110062539", "-", "110062837", ",", "DMR8", "=", "chr17:41278135", "-", "41278906", ",", "DMR9", "=", "chr2:27301195", "-", "27301943", ",", "DMR10", "=", "chr5:170288671", "-", "170288788", ",", "DMR11", "=", "chr12:52281482", "-", "52281997", ")", "were", "identified", "." ] } ]
PMC11714165
Next, deionized water (1.2 mL) was added to the above dried peptide.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "deionized", "water", "(", "1.2", "mL", ")", "was", "added", "to", "the", "above", "dried", "peptide", "." ] } ]
PMC11697189
Sunitinib (F); Temsirolimus (G); and Rapamycin (H).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sunitinib", "(", "F", ")", ";", "Temsirolimus", "(", "G", ")", ";", "and", "Rapamycin", "(", "H", ")", "." ] } ]
PMC10831439
Gates were set on lymphocytes, singlets, live iNKT or CD19-CAR-iNKT cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gates", "were", "set", "on", "lymphocytes", ",", "singlets", ",", "live", "iNKT", "or", "CD19-CAR-iNKT", "cells", "." ] } ]
PMC11773391
MM growth curve in nude mice (left panel) (*p < 0.05 and **p < 0.01 compared with the control group). (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MM", "growth", "curve", "in", "nude", "mice", "(", "left", "panel", ")", "(", "*", "p", "<", "0.05", "and", "*", "*", "p", "<", "0.01", "compared", "with", "the", "control", "group", ")", ".", "(" ] } ]
PMC6461034
Proteins that cannot be differentiated based on MS/MS spectra alone are clustered into protein groups (default MaxQuant settings).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proteins", "that", "can", "not", "be", "differentiated", "based", "on", "MS/MS", "spectra", "alone", "are", "clustered", "into", "protein", "groups", "(", "default", "MaxQuant", "settings", ")", "." ] } ]
PMC11754784
h Comparison between diffusion kinetics and target binding kinetics in cellular microenvironment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "h", "Comparison", "between", "diffusion", "kinetics", "and", "target", "binding", "kinetics", "in", "cellular", "microenvironment", "." ] } ]
PMC11021472
Some circRNAs can serve as sponges of microRNAs and thereby compete with other RNA transcripts for binding to microRNAs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "circRNAs", "can", "serve", "as", "sponges", "of", "microRNAs", "and", "thereby", "compete", "with", "other", "RNA", "transcripts", "for", "binding", "to", "microRNAs", "." ] } ]
PMC9429973
Among patients with high-risk cytogenetics, MRD negativity rates were 50.4% (63/125) vs. 37.4% (52/139; OR=1.70, 95% CI: 1.04-2.79, p=0.03) with Isa-RVd vs. RVd.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "patients", "with", "high-risk", "cytogenetics", ",", "MRD", "negativity", "rates", "were", "50.4", "%", "(", "63/125", ")", "vs.", "37.4", "%", "(", "52/139", ";", "OR=1.70", ",", "95", "%", "CI", ":", "1.04", "-", "2.79", ",", "p=0.03", ")", "with", "Isa-RVd", "vs.", "RVd", "." ] } ]
PMC11612794
All cell lines utilized in this study are listed in the key resources table.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "lines", "utilized", "in", "this", "study", "are", "listed", "in", "the", "key", "resources", "table", "." ] } ]
PMC11640476
The selection of incubation time is strictly dependent on cell type and concentration.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "selection", "of", "incubation", "time", "is", "strictly", "dependent", "on", "cell", "type", "and", "concentration", "." ] } ]
PMC11676674
In another set of experiments, C. monspeliensis extract at the same concentrations, namely 50, 100, and 200 μg/mL, was tested for its ability to attenuate MMC-mediated cytotoxic and genotoxic effects on CHOK-1 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "another", "set", "of", "experiments", ",", "C.", "monspeliensis", "extract", "at", "the", "same", "concentrations", ",", "namely", "50", ",", "100", ",", "and", "200", "μg/mL", ",", "was", "tested", "for", "its", "ability", "to", "attenuate", "MMC-mediated", "cytotoxic", "and", "genotoxic", "effects", "on", "CHOK-1", "cells", "." ] } ]
PMC11544122
Data were normalized to endocytosis of the WT receptor.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "normalized", "to", "endocytosis", "of", "the", "WT", "receptor", "." ] } ]
PMC11389534
By targeting nucleus localised substrates, UFMylation plays a pivotal role in maintaining genomic stability. , , , , ,
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "targeting", "nucleus", "localised", "substrates", ",", "UFMylation", "plays", "a", "pivotal", "role", "in", "maintaining", "genomic", "stability", ".", ",", ",", ",", ",", "," ] } ]
PMC11290772
We fully acknowledged the inherent heterogeneity of ROBO-1 expression within the samples of ovarian cancer patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "fully", "acknowledged", "the", "inherent", "heterogeneity", "of", "ROBO-1", "expression", "within", "the", "samples", "of", "ovarian", "cancer", "patients", "." ] } ]
PMC11756514
An overnight culture of transformed BL21 was diluted 40 times in Luria-Bertani media with 50 µg/mL kanamycin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "overnight", "culture", "of", "transformed", "BL21", "was", "diluted", "40", "times", "in", "Luria-Bertani", "media", "with", "50", "µg/mL", "kanamycin", "." ] } ]
PMC11697703
Two-tail unpaired t test, p values are presented as follows; ∗p < 0.05, ∗∗p < 0.01.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-tail", "unpaired", "t", "test", ",", "p", "values", "are", "presented", "as", "follows", ";", "∗p", "<", "0.05", ",", "∗∗p", "<", "0.01", "." ] } ]
PMC11047729
The next form, calcifediol (25-hydroxyvitamin D), is produced thanks to cytochrome P450 2R1 (CYP2R1) hydroxylation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "next", "form", ",", "calcifediol", "(", "25-hydroxyvitamin", "D", ")", ",", "is", "produced", "thanks", "to", "cytochrome", "P450", "2R1", "(", "CYP2R1", ")", "hydroxylation", "." ] } ]
PMC11759751
4The killing ability of CD19 CAR T cells was enhanced by the pretreatment of B-NHL cells with chidamide.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4The", "killing", "ability", "of", "CD19", "CAR", "T", "cells", "was", "enhanced", "by", "the", "pretreatment", "of", "B-NHL", "cells", "with", "chidamide", "." ] } ]
PMC6163708
HH inhibitors GANT61 or cyclopamine were present in media as indicated in Figures and Figure legends.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HH", "inhibitors", "GANT61", "or", "cyclopamine", "were", "present", "in", "media", "as", "indicated", "in", "Figures", "and", "Figure", "legends", "." ] } ]
PMC10203589
Analysis of FGF18 gene and protein levels by Oncomine cancer Genome Atlas database and Human Protein Atlas database showed that FGF18 expression was increased in breast cancer compared with normal tissues.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "of", "FGF18", "gene", "and", "protein", "levels", "by", "Oncomine", "cancer", "Genome", "Atlas", "database", "and", "Human", "Protein", "Atlas", "database", "showed", "that", "FGF18", "expression", "was", "increased", "in", "breast", "cancer", "compared", "with", "normal", "tissues", "." ] } ]
PMC11423992
Malignant B cells often exhibit markers as CD19, CD20, CD22, CD23, CD30, CD38, paired box 5 (PAX5), B-cell lymphoma-2 (BCL-2), B-cell maturation antigen (BCMA), lymphoid enhancer-binding factor 1 (LEF1), and others .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Malignant", "B", "cells", "often", "exhibit", "markers", "as", "CD19", ",", "CD20", ",", "CD22", ",", "CD23", ",", "CD30", ",", "CD38", ",", "paired", "box", "5", "(", "PAX5", ")", ",", "B-cell", "lymphoma-2", "(", "BCL-2", ")", ",", "B-cell", "maturation", "antigen", "(", "BCMA", ")", ",", "lymphoid", "enhancer-binding", "factor", "1", "(", "LEF1", ")", ",", "and", "others", "." ] } ]
PMC5025404
The ED50 value was calculated by complex sigmoid non-linear regression analysis using Sigma plot software (Systat software, Inc. Richmond, CA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ED50", "value", "was", "calculated", "by", "complex", "sigmoid", "non-linear", "regression", "analysis", "using", "Sigma", "plot", "software", "(", "Systat", "software", ",", "Inc.", "Richmond", ",", "CA", ")", "." ] } ]
PMC11675244
The present work aims to bring clarity to the cellular mechanisms controlled by the above-mentioned signaling pathways and discuss the potential success in targeting them as antitumoral therapies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "present", "work", "aims", "to", "bring", "clarity", "to", "the", "cellular", "mechanisms", "controlled", "by", "the", "above-mentioned", "signaling", "pathways", "and", "discuss", "the", "potential", "success", "in", "targeting", "them", "as", "antitumoral", "therapies", "." ] } ]
PMC11507371
This dual role—facilitating both cell survival and death—presents valuable therapeutic potential alongside inherent risks.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "dual", "role", "—", "facilitating", "both", "cell", "survival", "and", "death", "—", "presents", "valuable", "therapeutic", "potential", "alongside", "inherent", "risks", "." ] } ]
PMC9777812
Herein, we experimentally confirmed that bta-miR-106b could promote mammary gland epithelial cell proliferation by targeting CDKN1A, thereby activating the PI3K/AKT/mTOR pathway to regulate milk protein synthesis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Herein", ",", "we", "experimentally", "confirmed", "that", "bta-miR-106b", "could", "promote", "mammary", "gland", "epithelial", "cell", "proliferation", "by", "targeting", "CDKN1A", ",", "thereby", "activating", "the", "PI3K/AKT/mTOR", "pathway", "to", "regulate", "milk", "protein", "synthesis", "." ] } ]
PMC7185206
Box plots quantifying flow cytometry shown, compared statistically by Student’s t-test. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Box", "plots", "quantifying", "flow", "cytometry", "shown", ",", "compared", "statistically", "by", "Student", "’s", "t-test", ".", "(" ] } ]
PMC8584319
In terms of genetics, the neuroblastoma RAS viral oncogene homolog (NRAS) mutant cell line has a disrupted negative feedback loop between ERK1/2 and p38.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "terms", "of", "genetics", ",", "the", "neuroblastoma", "RAS", "viral", "oncogene", "homolog", "(", "NRAS", ")", "mutant", "cell", "line", "has", "a", "disrupted", "negative", "feedback", "loop", "between", "ERK1/2", "and", "p38", "." ] } ]