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PMC2614415
In summary, we have shown the mitotic kinase Aurora-A to be overexpressed in ovarian carcinomas compared to adenomas.
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PMC11694066
We next assessed replication fork progression upon PARPi and ATRi exposure in the JN1 cell line and found that their combination decreased fork velocity (siCNTRL DMSO, 0.82 kb/minute vs. siCNTRL talazoparib + M4344, 0.58 kb/minute; P < 0.0001, Mann–Whitney U test; Fig. 5B; Supplementary Fig. S15A), in line with these agents’ mechanism of action and increased replication stress.
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PMC9429973
The remaining three patients died during the fourth (n = 2) and fifth (n = 1) years of treatment.
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PMC7504302
The most significantly upregulated mesothelial marker genes in the epithelial group included cytoskeleton, transmembrane, cell junction and, extracellular matrix assembly genes, e.g., ELMO3, MSLN, ITLN1, SYT4, UPK3B, CLDN15, LRRN4, RSPO1, VTN, and KLK11.
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PMC11190062
Following 30 minutes of incubation at room temperature, 1 mL of 0.1 M Na2B4O7 (borax) was added to neutralize the pH. Cells were spun down and resuspended in PBS with 1% bovine serum albumin (BSA)/0.1% Tween.
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PMC11587606
The primer sequences were as follows: h-RHBDF1, 5’-TGCCGTGGATTGACAACTT and 5’-CACTCACAGCGGACAGGAT; h-Occludin, 5’-CATTTATGATGAGCAGCCCCC and 5’-TGCCATGGGACTGTCAACTC; h-ZO-1, 5’-CAAAAACAGCAGGCGGAGAC and 5’-AACAGGCTGAGCGGACAAAT; h-E-cadherin, 5’-CACCACGTACAAGGGTCAGG and 5’-GGGGGCTTCATTCACATCCA; h-GAPDH, 5’-GTCTCCTCTGACTTCAACAGCG and 5’-ACCACCCTGTTGCTGTAGCCAA; h-PKCζ, 5’-GGTGCGGTTGAAGAAGAATGA and 5’-TGTCGTCTGGAAGCAGGAGTG.
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PMC9822769
it is difficult to suggest which is the promoting agent of such a hydrolysis in 2 and 3 .
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PMC11704135
to facilitate the adherence of microbial strains to the respective medium.
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PMC11730320
Variant prioritization was conducted following a workflow that was previously described.
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PMC11637716
At the age of 3 months, the girl was admitted to our institution due to severe pancytopenia and increasing oxygen requirement, resulting in severe pulmonary insufficiency.
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PMC11638255
d Representative flow cytometry plots of CD11bLy6G neutrophil frequency of tumors plotted in (c).
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PMC9429973
C-statistic in training cohort was 0.706 (95% CI: 0.66-0.76).
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PMC11502327
Second, the stability of the multi-drug co-delivery system.
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PMC7724160
Specifically, cells were passaged to passage 12, 21, 25, and 37 and then used in this experiment.
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PMC11627133
The bifunctional aptamers are approximately 7‐fold smaller in weight and size than conjugates of primary and secondary antibodies, so that the expected linkage error to the target is smaller (Table S4).
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PMC11572213
Our results suggest that, in addition to the literature, a low-glutamine medium may regulate TET2 expression by activating AMPK.
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PMC10900886
The average percentage of VP1 cells in imDCs (10% ± 1) was significantly higher than in mDCs (4% ± 1) at 6 hpi (Fig. 4A).
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PMC9512971
These factors might have influenced the results of the virological endpoints used in this study.
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PMC11718817
Beside insights into the molecular regulation of macrophage–T cell interaction, the novelty of this paper lies in establishing a triple-cell-type spheroid model that produces consistent motility measurements.
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PMC10024132
Kaplan-Meier survival curves.
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PMC11477621
C NMR (100 MHz, CDCl3) δ 188.4, 173.5, 130.3, 130.1, 120.5, 108.1, 60.4, 49.5, 33.9, 30.9, 27.4, 22.1, 14.3.
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PMC9532503
The process parameters used for mAb production is listed in Table 1.
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PMC11757230
The growth of canine lymphoma cells was monitored over time in vivo using bioluminescence imaging.
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PMC4659567
Ru(η -p-cym)(3Claza)Cl2] (2): Anal.
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PMC11297139
The tornado plots of EWS/FLI1 on the cREs were generated with deeptools computeMatrix function with an option “scale-regions”.
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PMC11087766
All cells are representative of the population.
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PMC11449273
Plakoglobin modulates oncogenic activities of β-catenin by either promoting its degradation in the cytoplasm or inhibiting its interaction with tumor promoting transcription factors.
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PMC7192625
We suggest that interpreting chromatin structure as a network is a useful step in this direction.
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PMC11604768
After six hours of receptor agonist treatment (β2AR: 1 µM epinephrine; 5-HT2A: 100 nM 5-HT; D2R; 1 µM dopamine), we harvested RNA and analyzed differential barcode abundance between receptor alone and receptor with agonist conditions (Fig. 4a).
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PMC11451940
for C43H36CuN2O6·(H2O) (Mr = 758.3): C 68.1, H 5.1, N 3.7.
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PMC11576293
Also, S-allyl derivatives were nearly equipotent to S-alkyl congeners as antiproliferative agents but quite different in terms of lipophilicity.
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PMC11711935
Current research indicates that melasma is characterized by the accumulation of aging cells in the dermis of the lesional skin, along with senescent fibroblasts, which may contribute to the increased pigmentation observed in melasma.
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PMC10812665
Culture and differentiation followed established protocols .
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PMC11474209
SWNHsPolluted water0.03 μg/LA sensitive electrochemical immunosensor that offers a biocompatible immobilization and sensitized recognition platform for analytes was proposed by functionalizing SWNHs with the analytes for MC-LR detection.15NMRMagnetic nanoparticleLake water0.6 ng/gA sensitive and reliable toxin residue immunosensor was produced using magnetic nanoparticle relaxation.16ic-ELISAMonoclonal antibody (Clone MC8C10) (Immunosensor)Water0.1 μg/LClone MC8C10 was produced and characterized with a high level of specificity against MC-LR, which ic-ELISA detects.
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PMC11791432
The Chinese glioma cohort data in this study were obtained from the CGGA database (http://www.cgga.org.cn/).
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PMC7504302
Unfortunately, about half of the tumors are inherently chemoresistant, limiting the wide application of that antifolate small molecule.
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PMC11666785
This emboldens the advantage of detecting fortunate molecules in localization microscopy.
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PMC8708099
The solutions were filtered through 0.22 µm pore filters and stored at −20 °C for later dilution.
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PMC11591030
A probability level of p < 0.05 was chosen as the limit for statistical significance.
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PMC6600253
Stilbene can also be found in folk medicines used in Asia, such as those derived from Pterocarpus indicus, Polygonum cuspidatum, Rhodomyrtus tomentosa, Rheum undulatum, Melaleuca leucadendron, and Euphorbia lagascae .
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PMC8270637
This study will provide some experimental basis for liver cancer immunotherapy based on the tumor microenvironment.
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PMC10538569
Importantly, we also showed that GPI-scFv X5 is displayed on the surface of iDCs where it would be available to neutralize infection.
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PMC11126803
Data are presented as mean ± SD.
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PMC5034105
Reactions were incubated at 45 °C for 10 min, followed by 95 °C for 5 min, and then thermal cycled for 50 cycles (95 °C for 5 s, 55 °C for 30 s).
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PMC9847912
GSK232 was purchased from Cayman Chemical Company (Ann Arbor, MI).
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PMC11734514
The RNA isolate represented a template for RT-PCR, with primers designed using BLAST on the NCBI homepage (Table 1).4 The mRNA expression of genes associated with malignancy markers, including phosphatase and tensin homolog (PTEN), protein kinase B (Akt), mammalian target of rapamycin kinase (mTOR), STAT-3, hypoxia-inducible factor 1-alpha (HIF-1α), IL-6, VEGF, and GAPDH as an internal expression control (reference gene), was determined using MyTaq One-Step RT-PCR kit (Bioline, London, UK).
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PMC9822769
The polar surface area (PSA) of Complexes 1–3 has been calculated according to the previously published procedures .
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PMC11412752
STING is primarily known for its role in regulating the immune response against viral infections and certain intracellular pathogens.
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PMC11359735
GPI anchors have mostly been studied in the merozoites of Plasmodium falciparum.
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PMC11629192
The CSF anti-NMDAR antibody became negative after the second dose of OFA treatment.
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PMC6267596
MYC over-expression induces chromosome missegregation, which impacts microtubule nucleation, aster coalescence and centrosome dynamics.
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PMC11307990
The DNA nanotapes showed a slight reduction in ζ potential compared to 6HB-DONs.
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PMC10578720
For example, deacetylation of pyruvate dehydrogenase complex (PDHC) can enhance its enzymatic activity, increasing TCA cycle flux within macrophages and further activating IL-1β–related proinflammatory pathways.
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PMC11594588
It concerns practically all of the above-mentioned drugs and is associated, among others, with the occurrence of stent thrombosis, the consequence of which is death in 45% of cases .
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PMC9429973
In the Binet staging system, 40.8% patients were stage A, 27.6% were B and 31.6 % were C. Thirty patients were on therapeutic abstention initially.
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PMC9429973
17.7% of patients belong to the good risk category of ELN classification, 21.6% to the intermediate risk category and 30% to the adverse risk group.
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PMC9926039
Inc., Chicago, Ill., USA was used for the statistical analyses.
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PMC11476004
According to the authors, studies on spontaneous canine SCC can be a very useful model in preclinical studies of human disease.
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PMC11093197
Further analysis revealed that RB1 deficiency in MCF10A cells led to a significant reduction in the protein levels of cyclins A, B1, D1, E, geminin, and CDT1 and upregulation of p27, when compared with control cells (Figure 1E).
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PMC9917080
Background fluorescence was subtracted frame by frame using the Math Subtract plugin in ImageJ. Calcium responses were shown as a ratio of Fura-2 fluorescence intensities.
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PMC11680049
The cytotoxicity of extracts from in vitro evergreen Sequoia cultures suggests that they may be a potential source of particular, physiologically active compounds for phytopharmacognosy.
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PMC11412721
Mouse genotyping with multiple primer sets confirmed >99% C57Bl/6J genetic background after 10 backcrosses (primer sequences available upon request).
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PMC11424574
The in vivo metastasis assay was performed as published .
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PMC11766309
Additionally, to further investigate the biological significance of YKT6 expression in different tumor tissues, we conducted GSVA.
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PMC9429973
Continuous variables were expressed as means and standard deviations (SD).
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PMC11612794
These results are consistent with previous studies that showed phosphorylation of human CENP-T facilitates its interaction with Mis12C in vitro.
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PMC11785489
To identify these age-related TCRs, we applied IGoR to infer the number of nucleotide insertions in each thymic TCR.
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PMC11471176
Next, 50 μL of HRP-Conjugate reagent were dispensed into each well except the blank control.
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PMC9454178
When p < 0.05, the GO function was considered to be significantly enriched.
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PMC11359735
The gel was fixed, cut in half, and one half was incubated in 0.2 M KOH in methanol and the other in methanol alone.
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PMC11672881
Recent findings suggest that various dietary compounds exhibit anti-tumor properties by influencing several oncogenic pathways.
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PMC11627133
These genetically encodable tags, known as fluorescent light‐up aptamers (FLAPs), find application in visualizing and tracking of RNAs in live cells.[ , , ]
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PMC9111184
Principal Components Analysis (PCA) on the normalized spectra was carried out using OriginPro 2020b software.
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PMC11786156
Among the 20 patients with available survival status, five had died of the disease among 11 mortal cases.
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PMC9503669
As described above, all known Nef functions require protein–protein interactions with host cell proteins which are mediated by conserved amino acid motifs .
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PMC4277423
Briefly, 4×10 293T cells were seeded onto P-100 dish in 10 ml complete DMEM.
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PMC11679326
SW 1088 and Hs 683 showed no significant difference in binding to ConA and PHA-L, while LN-229, LN-18, U-373 MG, T98G, U-118 MG, and A-172 bound more to PHA-L, which recognizes the multi-antennary N-glycans presenting β1,6-GlcNAc complex.
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PMC11040965
When CD28 blockade was added, lower levels were detected for all but PI3Kγ.
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PMC11087301
These results suggest interconnection between EMT and VM phenomena and GOLPH3 as a therapy target .
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PMC11788920
Even higher levels of suppression were observed at the c-Myc protein level (0.10 ± 0.04-fold of control) when both RNP2 and RNP3 were employed together (Fig. 1D).
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PMC10317042
We excluded conventional cytotoxic agents, tyrosine kinase inhibitors, dyeing agents, and disinfectants from the 26 drugs, subjecting the remaining agents to a dose-dependent cell viability assay.
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PMC10344560
MN = mononuclear, PMN = polymorphonuclear.
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PMC11515150
On the contrary, a certain level of IL-15 was detected after 12 C CAR-NK cells killing multiple tumor cell lines (Fig. 6d).
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PMC6617630
The program consisted of 95 °C for 15 min, 25 cycles of 95 °C for 15 s, 58 °C for 30 s, and 72 °C for 30 s, followed by 72 °C for 10 min.
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PMC11547972
HRP-conjugated goat anti-mouse IgG and HRP-conjugated goat anti-rabbit IgG (Upstate Biotechnology, Lake Placid, NY, USA) served as the secondary antibodies.
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PMC9429973
All pts presented neutrophil and platelet engraftment and there was no difference in time of engraftment after ASCT between groups A and B (12 days in both, P=0.711).
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PMC11737091
Wound closure was monitored by imaging each well every 6 h. Tumor migration ability was assessed by measuring the scratch closure percentages in phase-contrast images.
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PMC11684297
Treatment with ZnO-NFs at 50 µg/ml and 100 µg/ml was done, and the cells were further incubated for 24 h. The positive control was hydrogen peroxide (H2O2) (40 µg/ml).
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PMC9429973
To be enrolled, PLT count at the start of LZ therapy had to be < 50×10/L. Results: A total of 40 FN episodes treated with LZ were identified.
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PMC9429973
This analysis is expected to occur approximately 2 years after the first pt is enrolled in Study ZILO-301.
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PMC6889484
Umbilical cord blood CD34 HSPCs were pre-stimulated for 24 h in Iscove’s modified Dulbecco’s medium (IMDM) supplemented with 20% BIT 9500 (STEMCELL Technologies, Cambridge, MA, USA), 50 ng/mL each of human interleukin-6 and thrombopoietin, 150 ng/mL human stem cell factor, and 100 ng/mL Flt-3 ligand (PeproTech, Rocky Hills, NJ, USA).
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PMC9429973
The primary endpoint is CR rate.
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PMC11354225
Therefore, the in vitro effect of EGCG on the heme synthesis pathway and the production of protoporphyrin IX was studied to elucidate the mechanisms underlying the interaction of EGCG with PDT to develop therapeutic approaches more effective against skin cancer, especially in cases resistant to conventional treatments.
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PMC11632064
The same procedure was used for sample preparation for STR profiling.
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PMC8998437
Apoptotic cells were stained with annexin V-Horizon V450 or annexin V-PerCp-Cy5.5 (BD Biosciences Pharmingen, Palo Alto, CA, USA).
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PMC11590870
Similar values regarding the reduction in oxidation in Caco-2 have been reported.
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PMC11052306
In order to perform a larger structure/activity study, pyridine–imine derivatives functionalized in the para position (relative to the nitrogen atom of pyridine) were also synthesized (series 11-Gn-[Cu] and 12-Gn-[Cu] in Figure 14).
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PMC11698348
This regulation may explain how proliferating basal epidermal keratinocytes commit to differentiation and how the epidermis is protected from cell growth abnormalities and disease.
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PMC11423992
Uncontrolled systemic cytokine release is a common major challenge for T cell-engaging immunotherapies, irrespective of the target or treatment modality .
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PMC11200978
Conversely, the highly regulated process of apoptosis is characterized by chromatin condensation, cell shrinkage, and blebbing into apoptotic bodies that are then phagocytosed to avoid an inflammatory response .
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