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OTAR3088
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BioData-CellLine_annotated

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PMC10376064
The body weight of the mice was monitored weekly.
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PMC5810978
10 or 10 copies).
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PMC9429973
At diagnosis, 6 (50%) resistant patients harbored 1 mutation in ASXL1 (3/12), DNMT3A (2/12) or TET2 (1/12) and 1 patient harbored 2 mutations (ASXL1 and WT1).
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PMC11470999
This study demonstrated that PF targets and degrades CIP2A protein, inhibits the PI3K/AKT pathway and c‐Myc activity, and induces tumor cell apoptosis.
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PMC10165258
Each dot represents one spheroid tested at a given combination.
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PMC11578343
The voltage across each zone is recorded using custom hardware that enables multi‐zone data acquisition in an inexpensive, compact form factor that does not rely on optical hardware (Figure S1A, Supporting Information).
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PMC11307990
Stability analysis of DNA nanotapes.
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PMC11607321
b MOSA’s partial dataset augmentation (missing value imputation) of drug IC50s compared to recent independent drug response screens.
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PMC7642379
The parental cell line HEK293 showed a notable difference in transcriptome profile compared to all the other cell lines along the first principal component (PC1).
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PMC11367939
Notably, Rab5 mutant-induced enlarged endosomes exhibit mixed characteristics of both early and late endosomes .
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PMC11597291
Then, the cells were stained with PBS containing 5 μL PI (1 mg/mL PI stock solution) for 1 min.
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PMC11679033
However, the addition of CIT induced formation of significantly more MNi compared to experimental group exposed to single CBD.
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PMC9954564
In addition, risk categories are defined using a regression model, which allows adjustment for population stratification.
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PMC9429973
Treatment with combination chemotherapy significantly reduced leukemic burden in the bone marrow of NSG mice (Figure 1B top).
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PMC9429973
Material from 6 oral history interviews (Italy, France, Netherlands) was compiled to illustrate cross-national themes and personal dilemmas.
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PMC3675084
Microtubule-stabilizing agents such as taxanes, epothilones, and microtubule-destabilizing agents such as vinca alkaloids are among the most effective chemotherapeutics used in the clinic .
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PMC11394112
All the images were acquired by auto-exposure in the chamber under dim illumination, followed by acquisition and overlay of the pseudo color image representing the spatial distribution of photon counts produced by active Luc within the animal.
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PMC5308810
As expected, drug-peptide combinations (at suboptimal IC20 or IC50 of drug and peptide dosages) were more effective than doxorubicin, cisplatin, AMD3100, or peptide alone, or any of the drug-AMD3100 combinations for eradicating A2780, A2780/ADR, and SKOV-3 (Fig 4F and S3 Fig).
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PMC11297139
In addition, the condensate formed by ARID1A without the Pfam domain was unable to attract BAF components and they stayed diffusive in the nucleus (Fig. 2g).
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PMC11453018
Lasso Cox regression involved tenfold cross-validation to identify the optimal value for the regularization parameter lambda (λ) , selected to minimize the partial likelihood deviance.
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PMC11525028
AG-401 (5 mg/kg daily, i.p.),
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PMC11643491
In this study, we focused on the effects of elongated versus spherical particles on the uptake of aggressive deformable cells.
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PMC11228511
Much of the nonfarnesyl-progerin was in the nucleoplasm (SI Appendix, Fig. S1 B–D), but some of it was located at the nuclear rim (colocalizing with lamin B1 and LAP2β) (SI Appendix, Fig. S1 B–D).
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PMC11672142
The UV–vis spectrum for Fe3(DefNEtTrp)2 shows a LMCT absorbance at 448 nm (ε = 11,000 M cm based on compound concentration) and at 512 nm (ε = 6400 M cm based on compound concentration).
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PMC9261184
Two OGI cameras were used simultaneously: the FLIR GF320x and the Opgal EyeCGas 2.0.
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PMC11725127
G, H) USP2 knockout MM.1S and RPMI 8226 cells were treated with 50 μg/mL CHX for the indicated time points.
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PMC6835428
In lacunae, MS and endothelial cells are close to each other and share a common basal lamina.
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PMC8633974
After 72 hours, cells were stimulated with TNFα, 15 ng/mL for 72 hours. (
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PMC10812665
Block in a hub may lead to (i) backwater in metabolic pathways, and (ii) to re-routing into pathways normally used less.
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PMC11680562
This implies that when the concentration of xanthan gum rises, the viscosity of the gel similarly increases.
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PMC11107915
In psychiatry, personalized care is essential for understanding the unique needs and conditions of individual patients.
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PMC11730000
In DOX-treated cells, there was an evident dependence on dose increase in DNA damage (Figure 6A).
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PMC11731614
Samples suspended in PBS are prepared using the standard uranyl acetate fixation for 5 mins seeded on EMS grids (TMS Catalog#71150) and imaged on a FEI Spirit 2 electron microscope.
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PMC9429973
LSC-targeted treatment strategies are limited because there are no known surface markers that are specific for LSCs in every leukaemia.
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PMC9429973
It contains a 4-1BB based CD19/CD7 dual directing CAR, a T cell enhancer, and genetically disrupted TRAC and CD7 loci to avoid GvHD and fratricide.
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PMC11544122
Data represent the mean ± SD from five (b) or three (d) independent experiments.
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PMC10565698
A Venn diagram was drawn by cross-analysis using the Evenn database (http://www.
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PMC9917080
Sorafenib has been shown to suppress reactive astrogliosis in the cerebral cortex under toxic effects of LPS, which may be a promising strategy for the treatment of neuroinflammation .
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PMC8973725
ZNF677 inhibits 786–0 cell proliferation and induces apoptosis. (
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PMC9429973
di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli - Federico II; CEINGE - Biotecnologie Avanzate, Napoli, Italy; Dept.
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PMC11200978
Samples were centrifuged at 300× g for 5 min, supernatant decanted, the resultant pellets resuspended in 500 uL 1x PBS containing CellEvent Caspase3/7 green, then samples were incubated at 37 °C for 25 min.
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PMC9429973
Compared to other hnRNPs, hnRNP K has the unique structural characteristic of containing three K-homology (KH) domains that allows it to bind both ssDNA and RNA sequences, as well as a K-interactive (KI) region that binds to multiple critical proteins such as Src, Fyn or Lyn amongst others.
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PMC10969097
Eligibility and selection: JF initially chose full-text articles for inclusion, which were then reviewed by SR.
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PMC9429973
Ropeginterferon alfa-2b, a peg-proline-interferon alfa-2b with improved pharmacokinetic properties, allowing for less frequent administration and better tolerability, has been shown in clinical studies (PEGINVERA, PROUD-PV, CONTINUATION-PV) to be efficacious and have a favorable safety profile.
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PMC10578720
Interestingly, a recent study implicated TLR2 as a key sensor recognizing HBV, which mediates response in hepatocytes by activating NF-κB-related signaling pathways in a MyD88-dependent manner.
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PMC8193046
Shown is mean ± standard error of the mean (SEM) of at least three independent experiments.
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PMC7090062
d, e Tumor cell proliferation was evaluated by Ki-67 immunohistochemical staining, and apoptosis by TUNEL assay.
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PMC4485648
To exclude the contribution of cell proliferation to the observed effect, we simultaneously monitored this parameter by real-time measurement of the cells plated in parallel, pre-treated in hypoxia and grown on the bottom of impedance plates.
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PMC10734950
The blocking buffer was then removed, and 1 ml of the undiluted sample was put into each well with the membranes and incubated overnight at 4°C.
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PMC10578720
Moreover, DCA treatment had a major impact on ROS production in M1 and M2 macrophages.
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PMC9341513
Viewpoints positioned at DHSs within the enhancers show reciprocal interactions with CCND1.
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PMC11609529
The Yes1-associated transcriptional regulator-mastermind-like transcriptional co-activator 2 (YAP1-MAML2 [YM]) fusion protein arises from an intrachromosomal inversion and is implicated in various cancers.
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PMC8414691
P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the mock group by Fisher’s exact test Cell division defects found in DOM-A depleted S2 cells CB, chromatin bridges; CM, chromosome misalignments; LIB, long intercellular bridges; MC, multinucleated cells; MS, multipolar spindles The results are expressed as mean ± SD values from three independent replicate experiments: *P < 0.05; **P < 0.005; and ***P < 0.0005 compared with the mock group by Fisher’s exact test Next, we stained DOM-A-depleted S2 cells with an antibody against Spd2, a Drosophila centriole protein used as a centrosome marker .
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PMC11271278
Using publicly available AmpliconArchitect results from WGS data of primary patient tumors included in the PCAWG project, we identified 1299 amplicons containing previously annotated oncogenes.
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PMC9429973
Heterogeneity of effect size was quantified using the I statistic.
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PMC5673060
We subjected the cell lines to stable isotope labelling with amino acids in cell culture (SILAC) with the PazR and DasR cells being ‘heavy labelled’ and the parental A204 cell line being ‘light labelled’ (Fig. 1B).
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PMC9684669
To determine if terfenadine blocked the CAMK2/CREB1 pathway, the expression of related proteins was measured following terfenadine administration.
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PMC11389534
Through regulating different branches of unfolded protein response (UPR) pathway in plasmablasts lacking IRE1α, UFBP1 UFMylation is not necessary for the plasmablast development, but is essential for ER expansion and immunoglobulin synthesis.
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PMC11519077
A flow cytometry assay was used to characterize MSCs in Passage 3, and the results revealed that MSCs were positive for CD73 and CD90 (MSC-specific markers), but negative for CD34 and CD45 (Figure 3).
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PMC11718109
B The corresponding line-scan analysis from the inset in (A) (dotted white line) is shown for both VMAT2-FLAG and VGLUT2-GFP.
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PMC10758402
Additionally, DMF was able to enhance ex vivo oHSV-1 infection of mouse-derived tumor cores as well as human patient tumor samples but not normal tissue.
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PMC9429973
Lastly, CD33 and CLL-1 dual edited cells also showed significant protection from CD33 and/or CLL-1 CAR-T cells.
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PMC5417661
Cells were stained for 1 h at room temperature (RT) in 5% goat serum in MBST containing primary antibodies against pericentrin (ab4448, 1:500; Abcam, Cambridge, UK) and alpha-tubulin (ab7291, 1:300; Abcam) followed by Alexa Fluor 488 and 555 dyes against mouse and rabbit antigens (Thermo Fisher Scientific) diluted 1:400 in MBST with 5% goat serum.
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PMC11342785
Scale bars represent 20 μm.
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PMC11012012
What is more, the authors demonstrated that SLAMF3/CD229 is naturally processed and presented as a tumor-associated antigen in primary CLL B cells (unstimulated or CD40L-stimulated).
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PMC11381192
Consensus matrix heatmaps showing the clustering of MM samples according to CSI gene profiles at k = 2. (
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PMC8632470
Such biomarkers, e.g., neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and calprotectin, are used as an early diagnosis of acute and chronic kidney injury .
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PMC11656048
Under the action of CHX (35 uM), the degradation pathway of protein changes from the traditional ubiquitination dependent pathway to the non-ubiquitination dependent pathway.
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PMC5673060
Pazopanib and dasatinib are multi-target TKIs that inhibit a distinct but overlapping spectrum of tyrosine kinases , , , .
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PMC9119314
The methodology for the semi-synthesis of 3–6 was adapted from the previous work by Castanet et al. (2002) and Bergström et al. (2017), in which it was shown that the direct region-selective iodination of aromatic compounds could be achieved with NIS in the presence of catalytic amounts of TFA or by using TFA as a solvent.
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PMC11248911
Compound 8 caused early apoptosis of 11.52% and late apoptosis of 17.11%, compared to the control MCF-7 cells with 0.37% and 0.15% early and late apoptosis, respectively, with total MCF-7 cell death of 32.91% compared to 1.95% for the control cells.
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PMC11786767
Ki-67 signal intensity (C) and chromosome areas (D) were analyzed for transfected cells.
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PMC8658661
As in several cases, a classification error crept in, and the HepG2 cell line was mistakenly labeled as hepatocellular carcinoma (HCC) instead of hepatoblastoma (HB), which caused considerable confusion for 30 years.
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PMC11525293
COVID-19 is an infectious disease caused by SARS-CoV-2 that started to spread at the end of 2019.
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PMC11655498
The abundance of Myc protein serves as a checkpoint switch for EBV lytic replication (Guo et al., 2020), and cytokines regulate EBV reactivation by modulating Myc expression (Biswas et al., 2021; Li et al., 2023).
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PMC11632064
Assessed with PrestoBlue HS and expressed as % of maximal viability.
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PMC10582049
In the tumor microenvironment CAFs participate in a number of biological processes including ECM deposition and remodeling, regulation of anti-cancer immune response, angiogenesis, and tumor cell invasion.
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PMC11787651
Results for drug-treated histone samples are comparable to those produced by the previous method and can be achieved using less than one-third of the instrument time.
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PMC11206251
To further understand the mechanism by which the PEIM exerts its effects, apoptosis was detected by flow cytometry, showing that the PEIM induced apoptosis of HepG2 cells, and the total apoptosis rate was 75.5% at a concentration of 50 μg·mL. RT-qPCR results showed that the PEIM could promote the relative expression of P53 mRNA and caspase-3 mRNA, which was a noteworthy finding from our study.
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PMC11721295
LC3-547 cells were cultured in complete DMEM (1% HI-FBS and 1% Pen/Strep) containing dox (1 μg/mL) and A427 cells in complete RPMI.
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PMC8632470
NAPQI cytotoxicity has been studied in lymphoblastoid cell lines derived from Caucasian-American, African-American, and Han Chinese-American healthy subjects.
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PMC8992508
Human MDR1 is expressed as a single polypeptide consisting of 1280 amino acid residues that are organised in two domains of 610 amino acids, joined by a short 60 aa segment termed the linker region.
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PMC11519567
D Pull-down assays of the SS18-SSX1-EGFP-Flag (SS-Flag) and SS18-SSX1(AR Mut)-EGFP-Flag (AR Mut-Flag) protein.
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PMC9412887
Where T12 peptide could facilitate blood–brain barrier (BBB) penetration, anti-PD-L1 nanobody was used as a targeting ligand for active targeting and simvastatin was utilized to repolarize the tumor-associated macrophages from the M2 to M1 phenotype for remodeling tumor microenvironments.
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PMC11665555
The GR-OXCT1KO and parental tumors were similar in terms of associated vasculature.
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PMC11767793
On the other hand, the Au-PEG-COOH@NIST was stable in PBS, showed a substantial loss of Au mass in DMEM (agglomeration was not clearly evident in DMEM) and some improvement (reduced loss/agglomeration) when FBS was present in DMEM.
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PMC11757131
In mice, the intake of 3-HIB through drinking water or intramuscular injection leads to the accumulation of diacylglycerol in skeletal muscles, indicating that 3-HIB promotes lipid synthesis in mouse skeletal muscle cells (21).
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PMC11412752
The detailed mechanisms underlying our findings warrant further investigation.
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PMC9024365
After 4 days, the anti-mitotic AraC was added at a final concentration of 5 μM. A half volume change of the NMM was performed every 5 days.
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PMC2777936
From these analyses, several Wnt receptors and ligands were abundantly expressed in undifferentiated EC cells and repression of several of these species inhibited EC cell growth.
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PMC9429973
Prophylactic/therapeutic replacement of congenital factor XI deficiency, associated with bleeding episodes, was indicated in 2 situations.
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PMC11659734
However, further experiments are needed to confirm these preliminary data.
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PMC9164404
However, although there were numerous reports on Pt(IV) drugs and their DDS, the molecular mechanism of them is still controversial.
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PMC11684297
It was fascinating to see that at a dose of as low as 50 µg/ml, the morphology of the cells started to change from bipolar slender shape to round.
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PMC9318744
They found that omicron infection was less dependent on TMPRSS2 activities and could enter cells primarily through the endocytic pathway, while delta preferentially enters cells through cell surface fusion.
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PMC11495567
Cells after 48-h treatment with the indicated concentrations of NSL-YHJ-2-27 (0, 1, 3, 5 μM) were collected, stained with annexin V/FITC and PI and analyzed on the Sony SH800 Cell Sorter.
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PMC4360730
The user selects ‘Experiment’ for the ‘Data Type’ facet.
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PMC9429973
stopped TPO-RA due to TEDS.
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PMC9429973
Most (63.4%) pts were males ≥65 years old (52.4%).
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PMC11701801
Ultimately, this cascade activates antiapoptotic signaling pathways.
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