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PMC9429973
Within the data, deregulation of several KDM-related ncRNAs was observed, e.g., CTC-482H14.5 (antisense RNA to KDM4B gene, downregulated in AZA responders), hsa_circ_0003889 (circRNA processed from KDM1A, downregulated in AZA responders), and hsa_circ_0001580 (circRNA processed from KDM1B, upregulated in AZA responders).
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PMC11047729
Telomerase, in particular, has been extensively studied in various cancer types, including leukemias, due to its involvement in carcinogenesis.
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PMC10329237
The BLM has been used in many studies conducted on the cellular and molecular mechanisms involved in the pathogenesis of IPF and the identification of novel therapies for this disease (19).
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PMC4395774
Antigen-specific cytolysis of targets was detected from gene corrected, CTL expressing WT PRF but not CTL expressing PRFmut (Figure 5b).
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PMC11352311
Molecular docking and affinity calculations between esculin and the proteins were then performed using AutoDock 1.2.0 Vina.
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PMC2944824
Western blots were visualized with the Odyssey.
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PMC10976516
TME changed with increased systemic NK cells and augmented IL-α, IL1-β, and GCSF.Ahmed et al.Recombinant GLV-1h107, GLV-1h108 GLV-1h109 contains the GLAF-1 gene under the control of the VV SE, SEL, and SL promoters, respectively.
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PMC10578720
In summary, these findings suggest that the activation of the TCA cycle in vivo plays a role in preventing the HBV particles from inducing M2-like polarization of macrophages.
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PMC11679326
C1qDC proteins are unexpectedly widespread molecules among many invertebrates, despite their lack of a classic complement system.
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PMC9429973
All pts received 8 intrathecal doses of MTX alternating with ara-C and mediastinal radiation was considered in pts with balky mediastinal disease.
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PMC11361748
Data are shown as mean ± SEM.
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PMC9429973
27.0%(17/63)occurred large masses(≥7.5cm).
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PMC11119602
They were collected by trypsinisation and grew similarly to non-resistant cells, but were less sensitive to the cisplatin; they became resistant (Figure 1B,C).
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PMC11666785
It may be noted that, low frequencies are in the centre of FFT image and high frequencies away from the origin.
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PMC4112127
The medium containing 5-Aza-dC or DMSO was changed every 24 h. The dose and timing of 5-Aza-dC was based on prior optimization tests .
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PMC9429973
Patients with bulky disease, nonGCB subtype, and double expressors experienced significantly shorter PFS (p=0.03, P=0.043, and p=0.025, respectively), but these features did not impact OS.
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PMC10547921
In contrast, tubulin polymerization inhibitors, such as maytansine compounds DM1 and DM4, block the polymerization of tubulin dimers by inhibiting the formation of mature microtubules.
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PMC9621239
Genetic distance (D), number of synonymous substitutions per synonymous site (dS) and number of non-synonymous substitutions per non-synonymous site (dN) were calculated using MEGA 7.0 to quantify the diversity of HBV X QS.
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PMC9429973
Neither did single inhibition of MCT1 or MCT4.
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PMC11640555
Based on studies already conducted in in vitro models , and to mimic the increased BBB permeability caused by GBM, cells were stimulated with LPS, disrupting the integrity of the BBB and inducing inflammation.
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PMC11543885
Z.L. was supported by the China Scholarship Council.
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PMC11352666
TC106 EWS cells were obtained from T. Triche (Children’s Hospital Los Angeles, Los Angeles, CA, USA).
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PMC10798140
Additionally, clinical trials are currently being conducted on the quinoline derivative pelitinib (EKB-569) for the treatment of colorectal and lung cancer.
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PMC11731161
Generally, bone marrow mononuclear cells were separated utilizing Ficoll density gradient sedimentation, followed by the isolation of CD138 cells through microbead separation (Miltenyi, Germany).
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PMC11706776
Comparison of SKCa (KCNN1, KCNN2, and KCNN3) gene expression in patients suffering from ES was performed by a Brown–Forsythe and Welch ANOVA and a Games–Howell multiple comparisons tests.
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PMC9429973
From cycle 2 onwards, the most frequent AEs included blurred vision (all grade 40%, Gr 3/4 20%), peripheral neuropathy (all grade 30%, Gr 3/4 10%), upper respiratory tract infection (all grade 30%, Gr 3/4 20%), dry eyes (all grade 20%, Gr 3/4 0%), neutropenia (all grade 20%, Gr 3/4 10%) and nausea (all grade 20%, Gr 3/4 0%).
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PMC11577421
For example, we recently showed that the glycocalyx of Chinese hamster ovary (CHO) cells can function as a charge-based barrier against the internalization of anionic polystyrene NPs.
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PMC10877303
Therefore, the order of the MERS-CoV genome is 5′ UTR-ORF1ab (Open reading frames)-S-ORF3-ORF4a-ORF4b-E-M-N-3′ UTR-poly(A) tail .
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PMC6600592
A series of oxime and oxime ether derivatives of (E)-4-(alkyl-imino)-4-(4-substitute-phenyl) cyclohexylbutanoate were designed for anti-HBV agents according molecular docking conclusions.
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PMC11745600
In contrast, low testosterone is known as a risk factor for diabetes.
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PMC11635087
Nu and Mt show nuclei and mitochondria, respectively.
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PMC11351758
The cells were then cleaned with HEPES and incubated with MTT solutions for 40 min at 37 °C.
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PMC11682224
Data are expressed as mean ± standard deviation; N = 3; **P < 0.01.
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PMC11334037
IGF2 was highly expressed in OE-IGF2-transfected cells compared with OE-NC cells, while IGF2 expression was low in sh-IGF2-transfected cells (P < 0.001).
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PMC9429973
The DADA2 tool was used to classify sequences into appropriate taxonomic groups.
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PMC9429973
After confirmation of relapse, patients may be enrolled in one of the open sub-trials, provided the detailed eligibility criteria are met.
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PMC11486946
Disturbing these processes can affect the signaling activity of the molecule, providing a potential mechanistic target for drug discovery.
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PMC8540692
Briefly, 100,000 cells of A-172 and T98G cell lines, and 150,000 cells of U-138 MG cell line were seeded on 6-well plates and incubated for 24 h. Afterward, the analyzed compounds were added in concentrations based on MTT results, and the cells were further incubated for 48 h. Cells treated with the vehicle (DMSO or PBS) and 100 nM topotecan were used as negative and positive controls, respectively.
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PMC10747139
Complex 21 inhibited colony formation and had a potential antimetastatic action, thereby impeding cell migration in the wound-healing experiment.
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PMC11489275
Table 1Clinical characteristics of MDA5 + DM-ILD patients who died within 1 monthVariablesTotal (n = 263)1 month survivor (n = 185)1 month non-survivor (n = 78)P valueDemographic dataAge, median, years53.0[48.0,62.0]51.0[46.0,58.0]57.0[51.0,63.0] < 0.001Male, n (%)176(66.9)127(68.6)49(62.8)0.359Smoke, n (%)38(14.4)21(11.4)17(21.8)0.028Symptoms and disease statusFever, n (%)138(52.5)82(44.3)56(71.8) < 0.001Duration, median, month2.0[1.0,3.0]2.0[1.0,4.0]1.0[0.7,2.0] < 0.001RP-ILD, n (%)121(46.0)54(29.2)67(85.9) < 0.001Cutaneous featuresMechanic hand,n(%)83(31.6)54(29.2)29(37.2)0.203Heliotrope rash, n (%)114(43.3)87(47.0)27(34.6)0.064Gottron’s sign, n (%)165(62.7)118(63.8)47(60.3)0.589Shawl sign, n (%)32(12.2)26(14.1)6(7.7)0.149Periungual erythema, n (%)33(12.5)27(14.6)6(7.7)0.123Raynaud phenomenon, n (%)14(5.3)10(5.4)4(5.1)0.927Skin ulcers, n (%)35(13.3)26(14.1)9(11.5)0.583V sign, n (%)74(28.1)58(31.4)16(20.5)0.074Musculoskeletal featuresArthritis, n (%)93(35.4)76(41.1)17(21.8)0.003Muscle weakness, n (%)70(26.6)56(30.3)14(17.9)0.039Laboratory findingsLymphocyte, median,10^9/L0.7[0.5,1.1]0.8[0.5,1.2]0.6[0.5,0.9]0.005Lymphocyte class, n (%)1(≥ 1.10 × 10^9/L)67(25.5)55(29.7)12(15.4)0.0462(0.55–1.10 × 10^9/L)126(47.9)85(46.0)41(52.6)3(< 0.55 × 10^9/L)70(26.6)45(24.3)25(32.0)ANA, positive,n(%)110(41.8)79(42.7)31(39.7)0.657RF, positive, n (%)23(8.7)18(9.7)5(6.4)0.384Ro52, positive, n (%)203(77.2)141(76.2)62(79.5)0.564ALB, (mean ± SD), g/L33.0 ± 4.233.9 ± 4.230.9 ± 3.3 < 0.001ALT, median, units/L53.9[30.6,82.7]53.9[29.8,82.7]52.7[33.3,84.6]0.553AST, median, units/L47.3[32.0,73.3]42.9[29.5,69.6]60.9[39.8,80.0]0.002CK, median, units/L55.0[30.0,133.0]56.0[30.0,132.0]51.0[27.0,152.0]0.773LDH, median, units/L378.0[290.0,502.0]343.0[265.0,454.0]466.0[393.0,618.0] < 0.001CRP, median, mg/L6.7[3.2,19.0]5.1[2.7,12.3]19.8[5.0,47.0] < 0.001ESR, median, mm/h39.0[23.0,56.0]33.0[20.0,51.0]44.0[31.0,63.0] < 0.001NLR, median5.9[3.5,10.0]5.0[3.2,8.7]8.7[5.4,13.3] < 0.001WBC, median, 10^9/L5.9[4.3,7.9]5.5[4.2,7.5]6.5[4.8,9.5]0.005 Clinical characteristics of MDA5 + DM-ILD patients who died within 1 month The study analyzed the dynamic changes of peripheral blood lymphocyte count in the 1-month survivor and non-survivor group from the first day to the 14th day after admission and combined the adjacent 2 days into one group, including 7 groups in total.
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PMC9429973
On the other hand, both groups showed an equal need for more information in areas such as psychosocial support and the side effects of treatment.
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PMC6182045
Cell viability was assessed via with trypan blue exclusion and cell counts and viability were monitored using the TC20TM automated cell counter (BioRad, Hercules, CA).
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PMC11144200
It is noteworthy that, in contrast to other control groups, the FC + LPS-RGD-Nb36-DOX group’s ability to kill target cells does not actually diminish considerably as the DOX dose drops.
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PMC6450504
Next, cells were incubated overnight at 4 °C with a 1:20 dilution of primary anti-β-tubulin antibody (mouse monoclonal to β-tubulin, G-8, sc-55529, Santa Cruz Biotechnology, Dallas, TX).
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PMC10213179
In addition, aptamers are much less immune-stimulating.
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PMC6133382
These studies suggest that the sialic acid–containing hybrid and complex carbohydrates incorporated in normal cell lines in some way interfere with the VRC01 binding site on monomeric gp120.
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PMC9429973
Low-SMI was more common in patients with CIRS≥6 (p=0.039).
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PMC4112127
However, survival is substantially better in patients diagnosed with early stage ICC and in those with ECC for whom surgical resection or combined neoadjuvant chemoradiation and liver transplantation are potentially curative [12-15].
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PMC11310713
Our results from hormone measurement in in vitro culture were similar, which means our GTBs act as hormone producers on behalf of the original ovaries.
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PMC9429973
Corticosteroids were administrated to 81.5% of pts, antiviral agents to 38.3%, IL-6 receptor inhibitor to 11.1%, antiviral monoclonal antibodies to 7.4% and intravenous immunoglobulin to 19.8% of pts.
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PMC11640476
The complete medium was used as a control (resazurin treatment = 0).
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PMC10024132
The cells were then stained with fluorochrome-labeled anti-Vδ2 and anti-Vγ9 mAbs and subjected to flow cytometry analysis in order to identify γ9δ2 T cells and evaluate their purity; anti-CD27 and anti-CD45 mAbs were used to assess the differentiation state.
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PMC7039683
Functional SNPs that lie in non-coding DNA may alter the activity of tissue-specific enhancers.
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PMC11772585
β-Tubulin was used for the normalization control.
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PMC11607638
The number of mosquitoes having completed a full blood meal was recorded every 10 min until all mosquitoes had done so.
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PMC11459296
PB-MNC humanization, although faster, is associated with high levels of graft-versus-host disease (GvHD) and associated mortality, and often lacks diverse lymphoid–myeloid representation.
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PMC11186948
Total RNA was purified and precipitated with chloroform and isopropanol respectively, and RNA pellets were washed two times with 75% ethanol.
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PMC11665584
T cell (Icos, St6galnca3), NK cell (Trdc, Xcl1), Macrophage 1 (Ccl8, Cbr2), and Dendritic 1–3 (H2-Ab1, Tmem176b; Cacnb3, Ccl22; Cxcl10, Ifit1, respectively) proportionally decreased while Neutrophil 1 & 2 (Retnlg, G0s2; S100a8, Ccl4, respectively) increased (Figure 7C and Supplemental Figure 13B).
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PMC9429973
CMV disease had impact on survival (median OS 6 months vs 40 if no disease; p-value 0.005/HR 0.36 (CI 0.17-0.76)).
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PMC11721277
Methyl alcohol for HPLC “Fisher Chemical”, Taiwan (Cat No. 1923759) was used as a wash solution for the autosampler.
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PMC7582629
Therefore, polarization-sensitive digital holographic imaging (PSDHI) combined with RS can be used to correlate information on morphology, birefringence and biochemical composition for a complete analysis of the cell sample.
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PMC9429973
Most responders achieved durable long-term hematologic improvement, and the rate of clonal evolution was similar to that seen in our SAA patients treated with rabbit ATG.
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PMC9429973
The median sample tumor mutational burden (TMB) were 2-hit in treatment-naïve CLL/SLL and 3-hit in RS DLBCL.
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PMC9429973
Recurring results in any 90-day period were averaged.
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PMC6133382
Colonies selected after MGAT1 gene inactivation were transiently transfected with a gene encoding A244-rgp120.
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PMC11794588
These plates were incubated in a CO2 incubator for 3.5 h at 37 °C.
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PMC7039683
Much of this potentially faint conservation overlies the elements conserved in the mammalian enhancer sequences (Supplementary file 2b).
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PMC11413393
Further investigation of PRMT1 sensitivity in ccRCC subtypes is warranted and would help facilitate a potential molecular-based stratification for drug responses.
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PMC11144200
Lastly, on day 28, ELISA was used to determine the serum levels of IL-2 and IFN-γ.
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PMC11790971
The mean total photon counts per cell is 3.17 × 10 (Fig. S11b).
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PMC9429973
No treatment-related deaths occurred.
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PMC9429973
Aims: The aim of this study is to clarify the role of selected ABC transporters in reduced sensitivity to chemotherapy in AML.
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PMC9952933
At least three independent experiments were performed.
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PMC10926885
Transfection was performed using Lipofectamine 2000 according to the manufacturer's protocol.
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PMC10932641
In the cell scratch test, compared with that of the blank control group, the migration distance in the negative control group was not statistically different at 24 and 48 h (P>0.05); compared with that of the negative control group, the migration distance of the siGPRC5D-AS1 group at 24 and 48 h was significantly longer (P<0.05); and compared with that of the negative control group, the oeGPRC5D-AS1 group had significantly shorter migration distances at 24 and 48 h (P<0.05) (Figure 7).
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PMC8978939
Our work reinforces the importance of studying specific variants to identify their biological impact.
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PMC7338939
Moreover, pre-treated cells with DAPT decreased the sphere number in sphere formation assay in passage 1, but the number and size of spheres significantly increased in the second sphere passages (Figure 2B).
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PMC11185260
Athymic mice with intracranial BT-12 tumor xenografts were randomized to therapy with scL-SMARCB1 and/or radiation therapy. (
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PMC11264242
Similarly, addition of FK228 induced FYN transcription and protein expression in Yamato-SS cells (Supplementary Figure S10).
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PMC11757131
A BCA protein concentration assay kit was used to determine the cellular protein concentration following the manufacturer’s instructions.
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PMC10748106
It can be observed that the most cytotoxic glycosylated iridoid (Figure S4f) has a higher electrostatic distribution, principally on the region rich in hydroxyls on the cyclopentane, which are excellent acceptors of hydrogen bonds.
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PMC9429973
A quality of life study (SF-36), disease severity score index evaluation (GD-DS3) and compilation of side effects are included.
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PMC11216402
For the GC cell lines, to generate a more compact set of TFBS motifs, we trained each set of positive ATAC distal peaks versus each other (300 pairs of experiments, n = 2000 differentially active sequences in each of the two cell types, median AUROC = 0.922) (Supplemental Fig. S27) and used the 19 most commonly detected motifs as PWMs to extract TF activity (AP-1, RUNX, AP2, NFKB, ZEB (AREB6), NFI, ONECUT, EBOX, EHF, TCF/LEF, TEAD, GRHL, HNF4A, HNF1B, HOXB13, FOX, KLF, SOX, GATA) (Fig. 1E; Supplemental Fig. S28).
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PMC11585565
The cells were washed three times with PBS before incubation with a secondary antibody tagged with Alexa-488 (BioLegend, 1:1,000 in blocking buffer) for 30 min.
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PMC10582828
The authors declare no conflicts of interest.
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PMC10165258
Of interest, synergistic interactions were found more effective when etoposide was applied first.
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PMC11406030
Orange/yellow color indicates the co-localization of the LMTK3 antibody and peptide.
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PMC11673902
Cancer cells undergo significant changes in their mechanical properties due to alterations in the cytoskeleton.
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PMC11650848
However, participants that had the G/G genotype and were in the FA-supplemented group maintained a higher score that aligned with the other genotypes in the study.
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PMC10362265
Fig. 3b shows how the structure of this region in the human complexes evolved over 500 ns.
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PMC11656657
A Box plot depicting B4GALNT1 expression across cancers and healthy tissues.
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PMC11788920
The DNA construct was prepared by annealing the TS and NTS strand in a 1:1 molar ratio (400 nM) at 95°C for 5–10 min, followed by either slow or fast cooling to room temperature.
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PMC11788920
The fraction of viable cells was reduced to (18 ± 4)% in case of simultaneous RNP2 + RNP3 treatment after 48 h. On the other hand, cell viability was maintained at (79 ± 3)%, which is slightly less than that of the control when RNP1 and RNP2 were introduced together.
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PMC11687167
SPIRE-1 and SPIRE-2 2.
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PMC10158546
NeuN expression was also detected in ReN lysate at day 0 StdD. To examine the kinetics of ReN cell differentiation over time, we also tracked protein expression through western blotting of neuronal and astrocytic markers in lysate collected at days 0, 7, 14 and 21 post-differentiation (Figure 1f).
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PMC9429973
On the contrary, HS showed increased hepcidin, with less marked increased of ERFE (9.9 ng/mL, P=0.02) and EPO (36.4 IU/L, P=0.005).
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PMC11574029
In mammals, there are four Notch receptors and five Notch ligands .
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PMC11718031
Figure 4A–H shows the lactate and ammonia concentration changes with culture duration for all basal media-feed combinations.
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PMC9964635
220.1576; found: 220.1574.
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PMC10812665
While AA contain 1-2 nitrogen atoms, many of their metabolites do not.
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