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PMC9000591
Additionally, the flavanone liquiritigenin was detected only in SE4, the strongest antioxidant fraction (Figure 1 and Table 4).
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PMC5025404
Specifically, recognition of the role of tumor necrosis factor alpha (TNF-α) in the pathogenesis of inflammatory rheumatic diseases has expanded the scope of drugs for these diseases (Alonso-Ruiz et al. 2008; Schiff et al. 2005).
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PMC11787355
e Cellular states of generated IPTOs with PTPRZ1 expression.
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PMC11796104
In this study, a total of 657 DEcircRNAs were detected in male osteoporosis, and a ceRNA network of four circRNAs derived from three hub genes, including SETD2, ATM and XPO1, was constructed.
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PMC10938336
For example, a study by Hu et al. demonstrated how targeting specific protein interactions within a PPI network could amplify the efficacy of drug combinations in oncology.
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PMC11541409
An untargeted metabolomic analysis of GIST xenograft samples treated with imatinib revealed that imatinib-resistant samples (KIT) exhibited the fewest number of statistically significant metabolites compared to imatinib-sensitive GIST samples (KIT and KIT) , confirming that imatinib has a reduced effect on imatinib-resistant cells.
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PMC9429973
Specific primers and a probe have been designed to monitor minimal residual disease during therapeutic treatment of the patients.
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PMC6160470
Moreover, recent study by Alam et al. showed that P-gp can go through ATP hydrolysis cycle even when UIC2 is bound to it.
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PMC11476666
The Hoechst dye was excited with UV laser at 405 nm and its fluorescence was measured with 450/40 and 660/20 long pass filter.
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PMC11088135
A YAP1 was predicted as a potential target of miR-376a-3p with StarBase.
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PMC11106977
Dendritic cells (DCs) are specialized cells that present antigens, and they play a crucial role in immunity and immune tolerance .
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PMC9429973
NLR and PLR were investigated for each patient at the first day of hospitalization and all patients were followed in order to notice who required intensive care unit (ICU).
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PMC11720107
In the SCC-15 cell line, Ornak and Violeta garlic extracts decreased LC3A mRNA expression by 45.3% and 6.4%, respectively, compared with the control (Figure 5F).
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PMC9429973
Aims: To describe real-world patient demographics, disease characteristics, clinical manifestations, treatment patterns, and clinical outcomes for patients with HES across Europe.
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PMC9429973
Audio recordings and transcripts from UK Infected Blood Inquiry held between October 2020 and January 2021 were analysed for content.
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PMC11509309
Finally, as endoplasmic reticulum (ER) stress due to misfolded protein aggregation is a hallmark of prion diseases , we evaluated the capacity of those bromotyrosine derivatives able to reduce PrP propagation to protect cells from ER stress.
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PMC10530622
The authors also isolated hepatocytes, which were non-steatotic, from an Agxt-knockout mouse to confirm that Agtx deficiency leads to the production of higher levels of oxalate from the three precursors, namely glyoxylate, hydroxyproline and glycolate.
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PMC11204465
Compound 73 showed good activity against Hep G2 cells with an IC50 value of 16.9 µM. When the cell cycle was arrested at the G0/G1 phase by 73, the experimental results from the flow cytometry assay demonstrated that the rate of cell apoptosis and mitochondrial membrane potential was also additively increased in a dose-dependent manner.
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PMC11804588
To find highly active double-stranded DNA deaminases suitable for SMF, He et al. screened various bacterial enzymes and identified two candidates—DddB and MGYPDa829—that displayed the necessary enzymatic activity and even sequence coverage.
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PMC11612315
i Pull-down assay using His-tagged exendin 9–39 and cell lysates from CHO K1 cells expressing human TRPV1 (‘T’) and naïve CHO K1 cells (‘C’).
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PMC11621493
In the presence of cytokines that stimulate Pla2g4d mRNA expression, however, we found substantial lipidomic changes implicating that PLA2G4D is involved in the remodeling of the lipidome under inflammatory conditions.
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PMC9812014
In vitro and in vivo mouse model investigations have shown that lycorine alkaloid is also anti-EV-71.
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PMC9429973
Overall, grade ≥ 3 TEAEs occurred in 79% (n = 48) of patients, with grade 5 TEAEs in 2 patients (both due to COVID-19).
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PMC11574271
Representative images were obtained at a magnification of 40× (Scale bar 1 µm).
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PMC8524093
It notably contrasts to other arboviruses, mainly from Flaviviridae family, such as DENV and ZIKV, from which highest viremia levels varies between 10 and 10 copies/ml in the same period of infection (Srikiatkhachorn et al., 2012; Valiant et al., 2019).
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PMC9776316
Moreover, we found that the JNK-cJUN axis mediated the transcription and upregulation of XRCC4 in ovarian cancer cells exposed to cisplatin.
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PMC11024707
Mi-RNA-23a is known to be a non-coding RNA, which belongs to the mi-RNA-23a-27a-24-2 cluster and is located on the 19th chromosome of the human genome .
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PMC11281366
It is important to note that the functional results of this study were obtained using transfected mimics of miRNA-26a.
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PMC9019892
Therefore, there remains an urgent need for more agents that can inhibit both the different resistance mutations of KIT and FGFRs, which are usually highly expressed in GISTs and participate signalling crosstalk with KIT, causing imatinib resistance .
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PMC7642379
However, there was not a clear trend of loss in gene copy number amongst transcriptionally down-regulated genes for any cell line.
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PMC11777207
Last, we outline how blocking cis PD-L1:CD80 interactions or mutation of the intracellular domain of PD-L1, in an imiquimod-induced murine model of psoriasis, limits DC migration to the lymph node, decreases interleukin-17 production by CD4 T cells in the lymph node, and reduces epidermal thickening.
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PMC11772585
GLUT1, a member of the GLUT family, plays a crucial role in initiating glucose utilization within cells.
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PMC11596967
All analyses were carried out using GraphPad Prism version 8.0 (GraphPad Software, San Diego, CA, USA).
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PMC10196713
The findings of the present study that ferroptosis in cisplatin-resistant OC cells can be induced by inhibiting the expression of Fdx1 may represent a novel therapeutic strategy for the treatment of platinum-resistant OC.
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PMC9429973
To distinguish it from clonal hematopoiesis, We called this Clonal hematopoiesis of indeterminate potential（CHIP）.
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PMC9504875
N protein, together with either FLAG-RIG-I, -LGP2, -MDA5, -TRIM25, or -RIPLET, was co-expressed in COS cells.
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PMC9429973
Summary/Conclusion: This audit highlights the treatment pathway and outcomes for all patients with MM undergoing ASCT over 10 years in our centre.
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PMC9268183
The review reported a total of 948 plants species used against cancer around the world.
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PMC11745823
The PP was delineated based on PPs%: 0 indicates less than 1%, 1 signifies 1%–10%, 2 denotes 11%–50%, 3 represents 51%–80%, and 4 exceeds 80% PPs.
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PMC8735881
Promisingly, gene therapy establishing a subset of HIV-resistant target cells has shown therapeutic efficacy and has high potential to mimic the cases known as the “Berlin patient” and the “London patient”.
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PMC11388384
Conceptually, mechanisms like transcytosis are similar to the topology-limited diffusion we observed during Hedgehog signaling, except that during transcytosis the confined populations of morphogens are intracellular rather than being membrane-associated.
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PMC9341513
Probes and cell line DNA were denatured at 75°C for 5 min followed by hybridization at 37°C overnight.
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PMC9429973
The pts median age was 69.0 years (range 46.0–80.0), and most were males (7, 63.6%).
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PMC11767725
As an anaerobic commensal, C. acnes thrives in the lipid-rich environment of sebaceous follicles.
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PMC9429973
The median duration of DARA therapy was 7 months (range <1–24); seven (26%) pts received additional Vd.
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PMC11075223
The formation of hydrogen bonds between cimiciphenone and the phenolic hydroxyl group of Tyr337, the active site of AchE, blocked the catalytic reaction.
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PMC11092418
Of all agents examined, the CDK1/2/5/9 inhibitor dinaciclib was the most potent agent and inhibited the proliferation of all four HBCCLs more effectively than the CDK4/6 inhibitors palbociclib and ribociclib (Table 2).
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PMC11548041
Cellular uptake of aptamer-functionalized MNVs.
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PMC10158546
Kill curve with puromycin antibiotic on non-treated ReN cells revealed a concentration of 0.5 µg/mL was sufficient to kill all cells after 48 hours. (
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PMC9503669
This results in displacement of the SH3 domain from its regulatory position on the back of the kinase domain, leading to constitutive kinase activation both in vitro and in cells (see Staudt et al. for a recent review).
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PMC8922418
By binding to the receptors, HIV-1 enters cells through membrane fusion and converts viral genomic RNA into double-stranded DNA (dsDNA) by RNA reverse transcriptase.
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PMC10823017
The decreased level of N-cadherin, p-vimentin, and vimentin and the increased level of E-cadherin confirm reduced malignancy.
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PMC11549612
The genetic alteration landscape of BOLA1, BOLA2, and BOLA3 genes in TCGA KIRC patients was investigated using the cBioPortal web resource.
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PMC8358006
However, how H3K27me3 and other chromatin modifications influence cell differentiation and development of ESCC remains unclear.
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PMC11756937
The cell aggregates were collected and seeded at multiple wells at optimal density.
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PMC2614416
The normal liver oxidoreductase has eight child nodes: oxidoreductase activity, acting on CH-OH group of donors (Seqs:130 Score:104.5.0), oxidoreductase activity, acting on paired electron donors, with incorporation or reduction of molecular oxygen (Seqs:46 Score:28.78), monooxygenase activity (Seqs:43 Score:28.75), oxidoreductase activity, acting on the aldehyde or oxo group of donors (Seqs:48 Score:31.75), electron carrier activity (Seqs:130 Score:126.4), GO:0016491 (Seqs:5), disulfide oxidoreductase activity (Seqs:39 Score:35.4), and oxidoreductase activity, acting on CH-CH group of donors (Seqs:66 Score:25.25).
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PMC7189327
The results implied that FASL was located on the cell membrane of keratinocytes at the basal cell layers and FAS/FASL was markedly decreased in BCC .
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PMC11615101
Currently, anti-cyclic citrullinated peptide (anti-CCP), and rheumatoid factor (RF) are used to diagnose the disease.
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PMC11768281
Co-stimulation with either DCs or macrophages is essential for effective T-cell activation .
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PMC8557138
SF-G bioink has been used to encapsulate both single-cell suspensions as well as cellular organoids for the development of tissue equivalents like cartilage, bone, and skin as well as disease models (Sasmal et al. 2018).
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PMC11711127
TolDCs are also thought to delete cells from the repertoire through expression of FASL and/or TNF-related apoptosis-inducing ligand, and both are attractive targets to enhance tolDC generation ex vivo (110).
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PMC9516447
A427, HCT116, and PANC-1 cells were transfected with siCtrl or si78 for 48 hr.
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PMC10719213
The overall mutation rate was similar in the pooled treated and nontreated cells (Fig. 5b).
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PMC6379402
Because we make ten runs of SAFE on the real (data) iCells, too, each pair of iCell and annotation sets is characterized by ten numbers of functional domains and their corresponding p values.
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PMC11342785
D, example image of a TPPP-FUS-PixDE synMAP-driven spear-like architecture.
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PMC9712534
Quantification of fluorescence recovery confirmed that G180I restores the nuclear mobility of TOP2B H58Y (Fig. 5b).
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PMC9429973
For every 0.1 increase in EImin (reflecting RBC deformability at hypoxia), the aOR was 0.50 (p=0.007).
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PMC11791478
For all PDX models, animals were randomized (6–8 mice per arm) and treated when the average tumor size was 150 to 250 mm.
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PMC10969097
However, it was observed that Pleurotus pulmonarius alone inhibited tumour growth by 22.6%, while cisplatin alone inhibited it by 35.5%.
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PMC11591038
Regions with a lower perfusion index showed spatial similarities with atrophy in the posterior cingulate cortex, temporal lobes, and angular gyrus, while regions with lower relative cerebral blood flow were specified to the territories of distal branches in posterior cerebral artery territories .
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PMC9429973
Median age was 67 (range 21-89) years for non R/R patients (NRR) vs 72 (19-89) for R/R group (p <0.001).
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PMC11754291
I = Irradiated, NI = non-irradiated, Sham = non-irradiated cell culture, KCM = keratinocyte-conditioned medium, WB = Western blot.
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PMC11670954
BA treatment partly reversed the increase in the expression of these proteins in the BL group compared with the LPS group in Fig 4D–4F.
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PMC9581083
N. tenuifolia has been marketed for the treatment of common cold and fever in Chinese proprietary medicines (Fung and Lau, 2002).
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PMC11643361
Complexes bearing more substituted and bulkier ligands exhibited reduced activity compared to the unsubstituted ones; the unsubstituted full-sandwich copper(II) bis(pyrazolyl)borate complex 16 exhibited the highest activity, with an IC50 value of 25.37 μM, whereas the least active was the copper(II) bis(3,4,5-trimethylpyrazolyl)borate complex 18, with an IC50 value almost twice as high at 44.21 μM. Nevertheless, all of the complexes demonstrated higher activity than cisplatin, with complex 16 exhibiting an activity nearly four times higher than that of cisplatin (Figure 4B) .
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PMC11357960
D–F) The percentage change in the relative mRNA expression of three SUMO machinery components (SUMO1, SUMO3 and UBE2I) was associated with the prevalence rates of NR.
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PMC10729469
Data presented as mean ± SEM.
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PMC11599565
This cell type has a distinctive neuronal and weak or absent epithelial signature, at least at the single-cell transcriptional level.
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PMC11720808
Anti-p-p65 Ser536 (93H1), anti-p-IκBα Ser32 (14D4), anti-IκBα (L35A5) and anti-TRAF6 (D21G3) were supplied by Cell Signaling Technology (CST; Danvers, MA, USA).
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PMC9429973
Results: The cohort encompasses 66 patients, from 50 families, including 7 with cyclic neutropenia.
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PMC10565698
G and H. Transwell migration and invasion assays were performed in SK-Hep-1 cells after overexpression of circUSP10 (G and H).
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PMC11317131
Encouragingly, combination mutants increased activity over wildtype Bxb1 integrase by up to 9.2-fold (Figure 5A).
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PMC8728081
The fluorescence-activated cell sorting (FACS) flow cytometry study was conducted (48 h after treatment) after propidium iodide (PI) staining to confirm particles uptake by cells.
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PMC8728081
Ayurvedic Kajjali and Rasasindura were gifted for research purpose by Shree Dhootapapeshwar Limited, Mumbai, India.
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PMC11224206
Observations such as these are particularly timely when considering energy metabolism in the early embryo.
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PMC11506827
In summary, our study demonstrates that GEF sensitizes human RCC cells to TRAIL-induced apoptosis by upregulating DR4/5 and modulating apoptotic protein expression (Figure 7).
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PMC2193049
Altogether, these results suggested that the sequence of peptide MAGE-3271–279 itself contributed to the improper processing of the MAGE-3 protein and led us to study the role of the proteasome in the deficient production of the antigenic peptide.
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PMC11770199
Photographs and volumes (D) of excised tumor tissue of colon cancer after the last treatment.
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PMC9727330
Binding Based-Cross Docking Analysis of Asp and NNDAsp Ligands and ASNS crystal structure The docking analysis presented in Figure 6 reveals that the ASNS protein residues ARG 184 and ARG 203 formed a hydrogen bond with an Asp ligand molecule (A).
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PMC10878518
Our results suggest that the OBP-401-mediated GFP expression system is a useful method for assessing virotherapy sensitivity in bone and soft-tissue tumors.
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PMC10506676
To examine morphological changes, hematoxylin and eosin (H&E) staining was used.
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PMC9318744
A simple, accessible human cell culture model permissive to SARS-CoV-2 variants is critical for identifying and assessing antivirals in a high-throughput manner.
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PMC6114978
Anti-LATS2 (rabbit polyclonal, catalog# 20276-1-AP) utilized for western blot (1:500) was obtained from ProteinTech (Rosemont, IL, USA).
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PMC9429973
Fourteen (36.8%) patients had kidney involvement and nine (23.7%) patients had liver involvement.
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PMC11633763
Additionally, glycolysis increases the resistance of tumour cells to ischemia and hypoxia.
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PMC9878562
In addition, we measured the changes in directionality of VAL-ko and VAL-wt in close proximity and plotted the data over time ( Figure 4F ).
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PMC11477621
Starting from propargyl bromide (15) and 4-(2-bromoethyl)benzoic acid (6), alkyne 16 and azide 17 were synthesized in a single step, respectively.
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PMC11496491
The tissue samples underwent a series of continuous processes such as homogenization, phase separation, water separation, RNA precipitation washing, drying re-dissolution, concentration/purity determination, electrophoresis detection, and then further extraction of total RNA.
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PMC6600592
ESIMS: m/z 291.1593 [M + H], 313.1413 [M + Na], calculated for C17H22O4 (290.36).
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PMC11765243
Considering the quantitative and qualitative changes observed in thymus development, the effects of p110α inactivation in spleen cell populations were analyzed.
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