Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9429973
One patient relapsed after 19 months.
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PMC9429973
Interestingly, ERK1/2 inhibition also counteracted the development of bone marrow fibrosis in Rom-treated mice.
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PMC6461034
Peptides are separated on an Ultimate 3000 nanoLC‐MS/MS system (Dionex LC‐Packings, Amsterdam, The Netherlands) equipped with a 20‐cm, 75‐μm inner diameter fused silica column, custom packed with 1.9‐μm ReproSil‐Pur C18‐AQ silica beads (120‐Å pore size; Dr. Maisch, Ammerbuch‐Entringen, Germany).
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PMC10747160
For direct infectivity controls for Raji cells, 96-well plates were prepped with poly-L-lysine, as described above.
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PMC9429973
Among all pts with sustained MRD negativity, only 1 D-RVd pt subsequently had disease progression, and 1 RVd pt died.
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PMC11354225
It can be applied to large areas of skin or lesions that are difficult to access, particularly providing satisfactory cosmetic results.
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PMC11240448
The oncogenic status of the fourth basal BC cell group, including its typical representative, the MDA-MB-231 cell line, is mainly driven by the PKC module, with mTOR and STAT3 playing secondary roles (Figure 6A).
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PMC7582629
Based on Raman spectral profile, differences in the composition of nucleic acids, proteins, lipids, and carbohydrates in cancer/normal cells helps in the evaluation, characterization, and discrimination of cancer stage .
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PMC9429973
All long-term survivors achieved remission following induction chemotherapy.
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PMC11024707
The present study aims to compare the levels of 7 mi-RNAs (mi-RNA-125b, mi-RNA-23a-3p, mi-RNA-146a-5p, mi-RNA-106a, mi-RNA-151a-3p, mi-RNA-125a, mi-RNA-28-3p) –that were previously shown to be associated with ASD– in the blood samples of autistic preschool children with ASD symptoms at different severity levels, and their non-affected siblings to compare with healthy controls.
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PMC5173112
Our study demonstrates that IL-8 affects the CSCs activity in RCC and how IL-8 activity is mediated by USP21 through its binding to the promoter region.
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PMC6182045
Thus, an effective vaccine remains a relevant strategy to stop the spread of HIV.
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PMC8409415
NFkB‐p65‐silencing cells were designated as A2780‐NFkB‐p65‐silencing cells.
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PMC11549062
In addition, the abnormal activation of PDGFR‐β may be related to the DNA damage repair process of cells, and the abnormal DNA damage repair may lead to the initiation of apoptosis .
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PMC9646302
Following 10–15 days of culture, the cells were fixed with 4% paraformaldehyde at room temperature for 20 min and subsequently stained with 0.1% crystal violet for 15 min prior to imaging.
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PMC9429973
The decreased hemolysis was associated with reduction in serum erythropoietin (EPO).
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PMC10362265
The movement of the helix/loop is shown in the second column.
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PMC11435360
NaHS directly releases H2S by dissociating into Na and HS, which subsequently binds to H. Cell viability was assessed by staining apoptotic and necrotic cells using FITC-Annexin-V and propidium iodide.
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PMC9429973
All PRT occurred in patients that were not receiving antithrombotic therapy.
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PMC11803918
Human melanoma cells A375 were seeded in confocal dishes (Corning 200350) and treated with γδ-T exosomes, hybrid exosomes, or Ce6-loaded liposomes for 4 h. Then, the cells were treated with or without light irradiation (Xe lamp, 650 nm, 6.4 mW/cm, 12 min).
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PMC11730305
The particles were somewhat spherical and with a size range of 33–46 nm.
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PMC11792090
To alleviate the host immune responses upon the infusion of UCAR-T cells, this module incorporates the extracellular domain of CD47, which provides a “don’t eat me” signal to macrophages and NK cells and suppresses innate immune signaling (23, 24).
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PMC7433824
MCY contributed to the proteomic analyses.
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PMC9545714
Moreover, we demonstrated a correlation between barrier strength to specific skin appearance‐related benefits such as reduction in redness and in pores and skin smoothening effect.
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PMC11411004
They similarly regulate the acetylation status of other non-histone substrates, such as important tumor suppressor proteins and oncogenes (Mrakovcic et al. 2019).
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PMC10812665
The accumulation of saccharopine in urine is a biomarker of an aminoacidopathy (saccharopinuria) (Figure S12), which—if left untreated—can lead to brain dysfunction .
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PMC11723947
They may also explain why the different HP1 paralogs are subject to at least partially distinct post-translational modifications.
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PMC11612508
The highest degree of swelling, 18.8%, was observed at a pH of 4.5, which was higher than at a pH of 7.4.
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PMC11371747
In most cell lines we quantified dCK activity and dCK mRNA levels.
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PMC10940855
Interestingly, expression of the EPH ligand, ephrin B2, has been linked to poor response to chemotherapy, decreased overall survival and disease-free survival in head and neck squamous cell carcinoma, pancreatic and bladder carcinoma (31).
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PMC11319300
H3K4me1 peaks were shown to surround the conserved region but no H3K27ac marks were detected, suggesting a potential poised enhancer state (Figure 5).
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PMC8170755
The percentage of alive cells in the presence of VPA was determined respective to the control cells grown in the absence of VPA (13).
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PMC11085211
In particular, it was subjected to reverse-phase medium-pressure liquid chromatography (MPLC), resulting in four FR2 subfractions (FR2-A, FR2-B, FR2-C, and FR2-D; Supplementary Figure S3) generated based on the chromatogram.
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PMC11495567
We then developed the polyisoprenylated cysteinyl amide inhibitors (PCAIs) as potential reversible inhibitors of PMPMEase enzyme.
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PMC9429973
On MV analysis, only chemo arm and post C1 OPR remained significant.
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PMC2777936
NT2/D1 and NT2/D1-R1 cells were individually transfected with siRNAs to knockdown FZD5 or FZD7, or with a control siRNA construct, pGL2 or RISC.
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PMC11543853
Enterovirus virions and free genomes diffuse from the ruptured endosomes to the cytoplasm, where additional virions release their genomes.
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PMC11697065
It has long been established that heterologous genetic elements used in the expression vector are a major determinant of biotherapeutic protein expression in CHO cells, and thus have a strong bearing on overall productivity , , , , , .
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PMC8427838
Cells were lysed in ice-cold lysis buffer supplemented with 2 mM Na3VO4 and a protease inhibitor cocktail.
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PMC11730311
The buffer was aerated with 5% CO2 / 95% O2 to maintain a stable pH at 7.4.
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PMC7022782
No presence of green dots or structures was detectable.
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PMC11290772
Incubating this recombinant protein with SKOV-3 cells, with or without ROBO1 expression, demonstrated successful binding of the recombinant protein to ROBO1-positive SKOV-3 cells. (
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PMC11655498
PIAS1 enhances Rta-mediated activation of EBV lytic genes via sumoylation, but PIAS1 inhibits Zta and C/EBP β-mediated Zp activation, and this inhibition does not rely on its SUMO ligase activity (Zhang et al., 2017).
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PMC9429973
Within the MDT cohort, 79% (n=38) achieved CR, 37 (77%) were consolidated, 7 pts relapsed, and 25 received HSCT.
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PMC11665584
Compared with control skin, the buccal mucosa had proportionally more Macrophage 2 & 3, Neutrophil 1 & 2, and Proliferating T cells and fewer Macrophage 1 cells.
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PMC11740508
We note that SUM149PT was always more sensitive to all drug treatments, suggesting that it may also express other modifiers that further potentiate these responses.
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PMC11699042
ATCC, American Type Culture Collection, DSMZ (German Collection of Microorganism and Cell Cultures).
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PMC9429973
The prognostic impact of the coexistence of ≥2 high-risk molecular abnormalities, including +1q21, compared to R-ISS, has not been validated adequately.
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PMC11638764
Here, we examined the impact of CB-5083 treatment in another cancer model, the HL-60 acute myeloid leukemia cell line, employing subcellular fractionation combined with label-free proteomics to analyze changes in protein levels across cytoplasmic, nuclear, and insoluble membrane protein compartments.
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PMC10936243
In fact, the newspapers that you see here, are purchased by the shelter as well.
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PMC11568601
In China, Tongguanteng injection (TGT) is widely used in the treatment or adjuvant treatment of various types of cancer.
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PMC11765988
Newly formed neoplastic cells can no longer be detected by the patient’s immune system.
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PMC11637284
A crude mitochondrial fraction, the pellet (P1) of 0.015% digitonin extracted cells, was further extracted with 1% digitonin, resulting in a supernatant termed SN2.
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PMC11700523
Thus, this study aimed to clarify the relationship between IS and MR activation in CKD and to develop the treatment of CKD.
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PMC9587298
Combining all this information and considering the initial profile obtained by HPLC-DAD (Fig. 1), it can be inferred that quercetin derivatives were less efficient in trapping MGO when compared to anthocyanins (Fig. 1).
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PMC6133382
Electroporation of CHO cells was performed using a MaxCyte STX scalable transfection system (MaxCyte, Gaithersburg, MD, US) according to the manufacturer’s instructions.
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PMC9221284
The contribution of these transcripts to the oncogenic activation of the t(8;22) c-MYC is discussed.
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PMC11707832
However, no notable variance in α-mannosidase activity was detected in the fluid extracted from ovarian cysts, indicating its potential diagnostic significance in distinguishing malignant gynaecologic cancers.
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PMC10079526
The inhibitors are specific for the SUMO E1 enzyme and don’t block the ubiquitin E1 enzyme UAE .
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PMC11764090
This surplus energy leads to a decrease in the photosynthetic rate and electron transport capacity, resulting in photoinhibition.
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PMC10936243
That has happened before.
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PMC11739696
The regulation of apoptosis involves a complex interplay of pro-apoptotic and anti-apoptotic factors, among which the tumor suppressor protein p53 and the anti-apoptotic Bcl-2 protein play significant roles.
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PMC11750712
Transduction efficiency was determined on day 3 after transduction, and further experiments were commenced on days 7–10 after transduction.
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PMC11612794
Asterisk indicates nonspecific bands.(D) The ratio of M phase population in indicated cell lines.
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PMC11683130
Target protease and expression of human serpins.
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PMC11055323
SS, SS18-SSX1.
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PMC5535901
Moreover, the treatments induced p65 phosphorylation at ser, which is predominantly cytosolic, suggesting activation of NF-κB signaling pathway.
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PMC11697189
CIBERSORT was employed for calculating the infiltration rate of 22 immune cells in ccRCC samples, and the infiltration of each ccRCC samples was shown by bar plot (see Supplementary Fig. S6 online).
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PMC9429973
The impact of acquired mutations in BTK and PLCg2 which mediate resistance to BTKi in CLL is unknown in MZL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "impact", "of", "acquired", "mutations", "in", "BTK", "and", "PLCg2", "which", "mediate", "resistance", "to", "BTKi", "in", "CLL", "is", "unknown", "in", "MZL", "." ] } ]
PMC9429973
Single knockout of the enzyme sensitized different AML cell lines for cytarabine treatment and showed impairment of proliferation as well as the ability to form colonies.
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PMC11451829
In contrast, a significant decrease in hyperemia was observed between grades 3 and 4 (P ≤ 0.0001).
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PMC11574271
D Upon the end of the study, all animals were dissected to confirm any organ metastases.
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PMC9429973
Of the patients achieving CR, all of them had responses >12 months.
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PMC9429973
In a sensitivity analysis including all 66 cases with FLC ratio ≥100 (independent of involved FLC concentration), we found the median TTP to be 41 months (CI 30-72 months), compared to 101 months for those with a FLC ratio <100 (CI 78-127 months; p<0.0001).
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PMC7504302
Indeed, a large body of evidence that accumulated over the last few years, suggests that the TGF-β signaling pathway is dysregulated in MPM.
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PMC10957991
Monolayer forces were monitored for both ctrl epithelial sheets and for epithelial sheets depleted for Trpv4 with specific siRNA.
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PMC11471176
The cells are then evenly distributed among 25 ml cell culture flasks, with carnosine solution (prepared earlier) added to two of them.
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PMC11534035
In CAL39 cells (Figure 4D), cell proliferation was not significantly affected by SERPINE1/PAI1 knockdown.
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PMC11599565
Investigating ovarian carcinoma cells obtained from fresh ascites (e.g. OC236 cells), we observed a population of cells with neuronal/stemness signature, accompanied by the expression of ABC transporters, which are widely expressed by stem cells as tool for chemoprotection and detoxification.
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PMC11730320
Variant calling and prioritization was also conducted based on an updated pipeline based on DRAGEN Bio-IT Platform v3.8.4 and the b38 genome reference, reaching the same conclusions (detailed results are omitted).Fig.
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PMC9429973
In the future, we would like to investigate the transforming capacity of the MYH9-PDFR-β fusion in an in vitro pro-T cell culture system.
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PMC11629192
Patient 3: An 11-year-old female exhibited anti-NMDAR encephalitis with seizure, consciousness disturbance, severe insomnia, agitation, behavioural changes, a decrease of verbal output, nystagmus and urinary and bowel disorders requiring an indwelling urinary catheter.
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PMC10040136
Breast cancer cells have been shown to induce the secretion of TGF-β by MSC through direct cell–cell contact .
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PMC9429973
In contrast, median PFS2 and OS were longer in fit patients (PFS2: 49.1m (34.6-74.1), OS: NR (66.6-NR)) versus intermediate-fit (30.1m (25.1-39.0); 51.2m (32.3-63.9) resp.)
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PMC11271278
Finally, we found cis-enhancer hijacking events activating potentially novel oncogenes such as ID4 in the prostate cancer cell line VCaP and TXLNA in the small cell lung cancer cell line CORL88 (Fig. 2E), which are likely caused by large deletions based on the known patterns of structural variants in the HiChIP signal (Figure S2B–D).
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PMC11536589
Unsupervised clustering of all KPC cells using the single-cell transcriptomes from GEO datasets GSE228502. (
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PMC11747467
A previous study also uncovered that pSTAT3 significantly increases in infiltrating basal bladder cancer compared to luminal bladder cancer (21).
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PMC9429973
One patient had undetectable CAR T cells by day 201.
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PMC10631132
A–H Representative CLSM images of hematopoietic cells from a PBMC-derived iPSC line A–D or a fibroblast-derived iPSC line (E–H) that had been differentiated either according to an embryoid body-based (EB) (A, B, E, F) or a monolayer-based (MB) protocol (C, D, G, H) were further subjected to osteoclast differentiation and stained for Cathepsin K (turquoise), F-actin (red) and counterstained with DAPI nuclear stain (blue).
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PMC10877303
H-bond acceptors9106Num.
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PMC11095939
Model of the negative regulatory role for Mecp2 in fine-tuning quiescence exit.
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PMC9429973
Accordingly, combined TNFR antagonist (R-7050) with ruxolitinib significantly reduces fibrocytes production in vitro in Asxl1-/-Jak2 mice and ASXL1 MF patients (Figure 1N-O).
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PMC9516401
IL-6 is one of the main cytokines in inflammatory responses; however, it could reinforce the activity of metalloendopeptidase.
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PMC11301242
Furthermore, differential expression and gene set enrichment analysis were performed using R packages DESeq2 and clusterProfiler .
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PMC10882807
Proteins were extracted in RIPA Lysis buffer (Beyotime, China) with protease and phosphatase inhibitors.
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PMC11354239
However, its expression in the glioblastoma tissue of patients responding to the therapy was associated with the presence of M2-type macrophages rather than to NK cells.
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PMC7570809
All experiments were performed in triplicate and repeated at least 3 times; a p value < 0.05 was considered to be significant.
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PMC11085211
Interestingly, all clusters contained phytochemicals characterized by the pyrogallol moiety, a polyphenolic structure already associated with proapoptotic activity.
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PMC9429973
Microangiopathic hemolytic anemia was noted in all patients with mean hemoglobin of 7.3 g/dl [5-8 g/dL], and 5% to 20% of schistocytes.
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PMC11522251
However, cetuximab treatment isn’t effective for all patients; indeed, a mere 10% of those with non-specific chemotherapy who have refractory metastatic colorectal cancer show positive responses to cetuximab alone .
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