Finding: Of the 7,612 mothers, 325 (4.3 percent) took folic acid supplementation almost daily preconception; 4,257 (55.9 percent) took it almost daily during the first trimester; 4,520 (59.4 percent) took it almost daily during the second trimester; and 4,416 (58 percent) took it nearly daily during the third trimester.
Certainty (1-5): 4.5