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singl molecul rna imag use mango ii array recent year fluorogen rna aptam spinach broccoli corn mango coral pepper gather traction effici altern label strategi background free imag cellular rnas howev applic somewhat limit relat ineffici fold fluoresc stabil recent advent novel rna mango variant improv fluoresc intens fold stabil tandem array possibl imag rnas singl molecul sensit discuss protocol imag mango ii tag rnas fix live cell

D031022

T168;T002

visual quantif subcellular rna local use singl molecul rna fluoresc situ hybrid advanc imag technolog especi approach allow imag singl rna molecul open new avenu understand rna regul synthesi decay high spatial tempor resolut describ protocol singl molecul fluoresc situ hybrid smfish use three differ approach synthes fluoresc probe three approach describ commerci avail probe singl molecul inexpens fish smifish hous enzymat label probe approach offer technic econom flexibl meet specif need experi addit provid protocol perform autom smfish spot detect use softwar fish quant

D017404

T063

identifi protein interactom target rnas use hypr ms rna protein interact integr maintain proper cellular function homeostasi disrupt key rna protein interact central mani diseas state hypr ms hybrid purif rna protein complex follow mass spectrometri high versatil effici technolog enabl multiplex discoveri specif rna protein interactom chapter provid extens guidanc success applic hypr ms system target rna interest well detail descript fundament hypr ms procedur includ experiment design control captur oligonucleotid qpcr assay formaldehyd cross link cell cultur cell lysi rna solubil isol target rna rna purif rt qpcr analysi protein prepar mass spectrometr analysi mass spectrometr data analysi

D040901

T091

pipelin analyz eclip iclip data htseq clip dewseq individu nucleotid crosslink immunoprecipit iclip sequenc deriv enhanc clip eclip sequenc method transcriptom wide detect bind site rna bind protein rbps chapter provid stepwis tutori analyz iclip eclip data replic size match input smi control read align use open sourc tool htseq clip dewseq includ prepar gene annot extract preprocess truncat site detect signific enrich bind site use slide window base approach suitabl differ bind mode rbps

D059014

T063;T059

par clip method transcriptom wide identif rna bind protein interact site post transcript gene regul ptgr rna bind protein rbps interact class rna control rna matur stabil transport translat describ photoactivat ribonucleosid enhanc crosslink immunoprecipit par clip transcriptom scale method identifi rbp bind site target rnas nucleotid level resolut method readili applic protein direct contact rna includ rbps predict bind sequenc structur depend manner discret rna recognit element rres thought bind transient rna polymeras helicas

D059467

T086;T081

rapid character crispr cas nucleas use cell free transcript translat system cell free transcript translat txtl system produc rnas protein ad dna coupl product biochem assay biomolecul rapid scalabl character without need purif cell cultur describ txtl appli character cas nucleas type vi crispr cas system nucleas employ guid rnas recogn complementari rna target lead nonspecif collater cleavag nearbi rnas turn rna target cas exploit numer applic includ vitro diagnost programm gene silenc eukaryot sequenc specif antimicrobi part describ method detail set txtl assay measur target collater rna cleavag cas well assay putat anti crispr protein overal method use character type vi crispr cas system use rang applic

D064113

T040

identif rna bind partner crispr cas protein prokaryot use rip seq crispr cas system consist complex ribonucleoprotein rnp machineri encod prokaryot genom confer adapt immun foreign mobil genet element especi class type ii crispr cas rna guid system singl protein effector modul recent receiv much attent applic programm dna scissor use genom edit eukaryot mani studi concentr effort improv rna mediat dna target type ii system littl known factor modul process bind crispr rna crrna guid tran activ tracrrna nucleas protein cas whether cas also potenti interact endogen rnas encod within host genom describ rip seq method global identifi direct rna bind partner crispr cas rnps use cas nucleas exampl rip seq combin co immunoprecipit coip epitop tag cas follow isol deep sequenc analysi co purifi bound rnas method use studi interact cas known interact partner crrnas tracrrna nativ system also reveal potenti addit rna substrat cas exampl rip seq analysi cas foodborn pathogen campylobact jejuni cjeca recent identifi sever endogen rnas bound cjeca rnp crrna depend manner lead discoveri pam independ rna cleavag activ cjeca well non canon crrnas rip seq easili adapt effector rnp choic crispr cas system allow identif target rnas deciph novel rna protein interact crispr cas protein within host bacteri genom lead better understand molecular mechan function system enabl us use vivo identifi interact rule design principl nucleic acid target applic fit nucleas interest

D064113;D000072669

T040;T063

explor ribosom posit translat transcript ribosom profil emerg ribosom profil tool measur translatom provid research valuabl insight post transcript regul gene express despit biolog insight technic improv made sinc techniqu initi describ ingolia et al scienc ribosom profil measur subsequ data analysi remain challeng describ lab protocol perform ribosom profil bacteria yeast mammalian cell protocol integr element three publish ribosom profil method addit describ tool call riboviz carja et al bmc bioinformat https githubcomribovizriboviz analysi visual ribosom profil data given raw sequenc read transcriptom inform eg fasta gff speci riboviz perform necessari pre process map raw sequenc read riboviz also provid user various qualiti control visual

D012270

T026

analysi mrna translat polysom profil mrna translat key step gene express allow cell qualit quantit modul cell proteom accord intra extracellular signal polysom profil comprehens techniqu studi translat state mrnas protein machineri associ mrnas translat describ procedur common use laboratori gain insight molecular mechan under translat regul pathophysiolog condit

D014176

T044

predict rna secondari structur use vitro vivo data new flow high throughput rna secondari structur data come differ techniqu allow develop machin learn approach develop cross crossal two algorithm train experiment data abl predict rna secondari structur propens vitro vivo sinc vivo fold rna molecul depend multipl factor due cellular crowd environ predict complex problem need addit calcul interact protein molecul follow chapter describ differ predict rna secondari structur propens use experiment data input artifici neural network ann vitro vivo

D016571

T170

introduct bioinformat resourc post transcript regul gene express untransl region mrna utr involv defin fate transcript process mrna local degrad translat initi regul sever other action tran factor rna bind protein non code rnas combin presenc defin sequenc structur cis element ultim determin protein synthesi level identifi function region utr uncov post transcript regul act upon thus paramount import understand regulatori layer task approach comput reduc testabl hypothesi space drive experiment valid effect waythi chapter focus present databas tool allow studi various aspect post transcript regul includ profil activ translat mrnas regulatori network analysi eg rbp ncrna bind site tran factor bind site predict motif search sequenc secondari structur aspect regulatori layer two potenti analysi pipelin also present practic exampl tool could integr effect employ

D019295;D005786

T045;T091

emerg endoscop ultrasound guid cholecystoduodenostomi prevent r resect pancreaticoduodenectomi pancreat cancer endoscop ultrasound guid biliari drainag main choledochoduodenostomi common use rescu therapi endoscop retrograd cholangiopancreatographi ercp malign distal biliari obstruct due un resect pancreat cancer altern cystic duct patent choledochoduodenostomi feasibl perform endoscop ultrasound gallbladd drainag advent lumen appos metal stent lam shorten simplifi procedur howev mani concern exist perform procedur metal stent preoper resect tumor evid endoscop ultrasound gallbladd drainag surgeri pancreat cancer scarc emerg endoscop ultrasound eus gallbladd drainag cholecysto duodenostomi perform due acut cholang set resect pancreat tumor surgeri neoadjuv therapi done three month later complet resect tumor feasibl eus guid gallbladd drainag use lam preclud perform complet resect pancreat head tumor

D002779;D010190

T191;T047

eosinophil pancreat present ruptur pancreat cystic lesion chest caviti year old man receiv follow examin retent cyst pancreat bodi extend dorsal extrahepat area present emerg depart hospit dyspnea cough chest x ray show larg amount left side pleural effus abdomin comput tomographi ct show reduct size cystic lesion biochem test pleural effus reveal high level pancreat enzym therefor diagnos ruptur pancreat cystic lesion chest caviti endoscop retrograd cholangiopancreatographi ercp demonstr stenosi pancreat duct leakag contrast medium cystic lesion ct ercp reveal leakag contrast medium cystic lesion dorsal extrahepat area chest caviti endoscop naso pancreat drainag perform cystic lesion pleural effus remain unimprov distal pancreatectomi therefor perform microscop examin reveal eosinophil infiltr pancreat parenchyma lead diagnosi eosinophil pancreat ep pancreat retent cyst secondari chronic pancreat associ eosinophil infiltr consid ruptur chest caviti ep rare etiolog pancreat case report case thus consid valuabl

D010181;D010195

T046;T047

csii relat stabl glycemia adult type diabet purpos present studi compar basic glycem control paramet hbac cv hypoglycemia well qualiti life depress score patient type diabet use continu subcutan insulin infus csii versus multipl daili inject mdi

D003922

T047

identif non invas exercis threshold method strategi onlin app increment exercis two threshold may identifi standard gas exchang ventilatori measur first signifi onset blood lactat accumul lactat threshold lt second onset metabol acidosi respiratori compens point rcp abil explain threshold occur identifi non invas pulmonari gas exchang ventilatori variabl fundament field exercis physiolog requisit understand core concept includ exercis intens assess prescript perform review intend uniqu comprehens theoret practic resourc instructor clinician research lab technician student undergradu graduat level facilit teach comprehens proper non invas identif exercis threshold specif object explain under physiolog produc lt rcp introduc classic non invas measur threshold identifi connect variabl profil under physiolog behaviour discuss common issu obscur threshold detect strategi identifi mitig challeng introduc onlin resourc facilit learn standard practic specif exampl exercis gas exchang ventilatori data provid throughout illustr concept novel onlin applic tool design specif identifi estim lt lt rcp introduc applic uniqu platform learner practic skill real exercis data anyon analyz increment exercis data purpos identifi lt rcp

D063731

T170

humor respons sar cov vaccin peopl live hiv describ humor immun respons covid vaccin peopl live hiv identifi factor associ magnitud anti sar cov antibodi concentr

D000086382;D015658

T047;T067

perceiv barrier assess manag femal sexual dysfunct survey among resid traine psychiatri author examin perceiv barrier assess manag femal sexual dysfunct among resid traine psychiatri

D007396;D001523;D011570

T048;T065;T097;T091

involv posterior cerebellum reconstruct predict social action sequenc recent advanc social neurosci highlight critic role cerebellum especi posterior cerebellar crus social mental ie theori mind research past year provid grow evid support view posterior cerebellum build intern action model social interact predict peopl action execut like respons action paper present overview seri fmri experi novel task involv combin learn generat chronolog sequenc social action either explicit implicit manner b requir social mental anoth person mental state goal belief impli trait togeth result strong confirm central role posterior cerebellar crus identifi automat action sequenc social mental predict futur action sequenc base social mental infer other research program import implic provid first time fruit start point diagnos investig social sequenc dysfunct varieti mental disord also relat cerebellar dysfunct b provid necessari tool test whether non invas neurostimul target posterior cerebellum causal effect social function c whether stimul techniqu train program guid novel cerebellar social sequenc insight exploit increas posterior cerebellar plastic order allevi social impair mental disord

D002531;D000076563

T041;T023

safeti profil gsk inactiv quadrival season influenza vaccin belgium germani spain passiv enhanc safeti surveil studi influenza season season influenza infect million annual europ annual influenza vaccin effect measur reduc risk infect complic especi among young children older adult

D064420;D007252;D007251

T046;T037;T129;T121;T047;T109

linac report steer error insensit mv fff transvers beam posit deviat clinic signific beam posit deviat observ mv fff beam patient specif qa elekta linear acceler signific report transvers steer error machin ion chamber routin linac qa practic includ cardin angl winston lutz test identifi deviat subsequ investig use electron portal imag devic epid reveal clinic signific beam posit deviat small steer error prompt investig impact possibl solut test set point establish adjust transvers steer current achiev introduc steer error test set point includ scan water tank profil epid imag propos method adjust error sensit test via adjust loop paramet report error correspond specif beam posit deviat test set point result posit deviat greater mm report error less new method improv error sensit implement work shown exist vendor protocol establish beam steer error mv fff beam lead beam posit deviat without machin interlock signific report steer error thus altern method establish steer error sensit base posit deviat present

D003952;D010315

T074;T073;T060

age specif normal refer rang tc dtpa glomerular filtrat rate use two sampl slope intercept method jodal brochner mortensen correct glomerular filtrat rate gfr vari age calcul method correct factor slope intercept overestim henc normal refer rang accompani result suitabl adapt method use nuclear medicin depart use two sampl slope intercept method lack appropri age specif normal refer rang hindranc adopt recent updat jodal brochner mortensen jbm correct older wide use method retrospect analysi routin gfr calcul clinic report generat local carri gfr calcul tc dtpa plasma clearanc use two sampl slope intercept method jbm correct age specif normal rang equat develop normal healthi subject publish normal refer rang modifi appropri correct revers compar local develop refer rang age specif normal gfr refer rang tc dtpa slope intercept method jbm correct develop valid current literatur normal refer rang mean sd normalis gfr ml min within confid limit suitabl use jbm correct children year age adult avail age specif normal gfr refer rang applic target popul appropri tailor calcul method correct factor enabl nuclear medicin depart updat calcul method line current literatur also facilit accur report evalu calcul gfr result

D016284

T121;T130;T109

hepatocellular carcinoma patient portal vein thrombosi treat robot radiosurgeri interim result prospect studi prospect studi evalu role stereotact bodi radiotherapi sbrt cyberknif ck indian patient suffer hepatocellular carcinoma portal vein thrombosi hcc pvt

D016461;D016634;D065287

T061

occurr fumonisin produc black aspergilli australian wine grape effect temperatur water activ fumonisin product niger welwitschia black aspergilli common mycotoxigen fungi vineyard worldwid aim research assess occurr fumonisin produc black aspergilli australian wine grape effect environment factor fumonisin product niger welwitschia syn awamori thirti eight aspergillus isol black aspergilli collect six wine grape varieti grown australian vineyard lc msms analysi cultur extract reveal six isol produc fumonisin fb fb molecular data reveal fumonisin produc isol niger welwitschia none refer isol carbonarius tubingensi japonicus foetidus posit fumonisin product effect temperatur water activ growth product fumonisin studi use two niger isol welwitschia synthet grape juic medium sgjm c c c c w w w level isol produc fb fb w w c c c highest growth rate observ mmday welwitschia w c wherea highest fumonisin product observ mgkg w c welwitschia none isol produc fumonisin c water activ level knowledg first report occurr fumonisin posit isol aspergillus australian wine grape impact environment factor fumonisin product welwitschia

D037341;D009793;D027843;D014920

T129;T131;T002;T168;T116;T109

effect urolithin bone repair mice bone defect bone defect difficult manag clinic big challeng repair secondari metabolit sourc herb shown potenti treatment bone defect

D059630;D010012

T042;T025

epidemiolog clinic manifest cardiac amyloidosi cardiac amyloidosi consid rare diseas garner signific attent last year due three key reason first increas recognit diseas conjunct various common cardiac condit heart failur preserv eject fraction aortic stenosi second due advent promis new therapi light chain diseas al transthyretin attr cardiomyopathi amyloid neuropathi final advanc cardiac imag includ echocardiographi magnet reson imag nuclear cardiac scintigraphi aid non biopsi diagnosi attr cardiac amyloidosi hereditari form attr come import avail genet test increas preval certain mutat african american recognit non cardiac clue diseas gain import reiter high clinic suspicion detail patient histori examin appropri use imag vital confirm diagnosi

D028227;D000686;D001024;D009202;D006333

T046;T047

multimod imag approach cardiac amyloidosi part recent advanc cardiac imag genet treatment option cardiac amyloidosi ca recogn import diagnos condit contribut cardiovascular morbid mortal although still consid rare diseas ca recogn import contributor heart failur preserv eject fraction hfpef low gradient aortic stenosi two import condit common face clinic practic review use clinic scenario highlight complementari role tradit imag tool electrocardiogram ecg echocardiographi echo conjunct advanc cardiac imag cardiac magnet reson cmr nuclear cardiac scintigraphi use bone avid tracer comprehens workup ca also highlight import workup light chain diseas part integr imag find discuss key aspect various imag modal final algorithm integr clinic suspicion laboratori test imag workup ca present

D000686;D009202;D006333

T046;T047

rna secondari structur analysi reveal potenti emerg pathogen flavivirus flavivirus genus divid four group mosquito born flavivirus tick born flavivirus known vector flavivirus insect specif flavivirus million peopl affect worldwid everi year due flavivir infect utr rna genom play critic role biolog flavivirus explor correl topolog utr pathogenesi global scale studi rna secondari structur differ group flavivirus conduct found pathogen flavivirus irrespect mode transmiss tend form shape topolog stem loop utr current non pathogen flavivirus also observ form shape structur base studi propos flavivirus shape topolog utr region may potenti becom pathogen

D009033;D005416

T204;T005

develop three dimension integr type reconstruct formula magnet reson elastographi viscoelast storag modulus loss modulus live tissu known relat diseas magnet reson elastographi mre quantit method non invas measur viscoelast viscoelast calcul elast wave imag use invers algorithm estim accuraci invers algorithm degrad background nois studi aim propos novel invers algorithm applic noisi elast wave imag

D054459

T060

go chang way train qualit evalu transform faculti develop workshop relat littl known faculti develop fd activ help particip achiev sustain behavior chang qualit studi evalu medium long term impact fd workshop inform transform learn tl theori aim discov aspect fd prompt healthcar profession hps adopt effect teach learn practic

D004501;D005178

T065;T097

congress neurolog surgeon systemat review evid base guidelin updat role target therapi immunotherapi manag progress glioblastoma follow question recommend pertin follow target popul recommend appli adult progress gbm undergon standard primari treatment surgeri andor chemoradi question adult progress glioblastoma use bevacizumab monotherapi superior standard salvag cytotox chemotherapi measur progress free surviv overal surviv

D000970;D001932;D005909

T121;T191;T109

congress neurolog surgeon systemat review evid base guidelin treatment adult progress glioblastoma updat introduct method manag glioblastoma time progress import facet physician involv neuro oncolog updat evid base guidelin manag progress glioblastoma publish congress neurolog surgeon american associ neurolog surgeon

D005909

T191

congress neurolog surgeon systemat review evid base guidelin updat role imag manag progress glioblastoma adult recommend appli adult glioblastoma previous treat first line radiat chemoradiotherapi suspect experienc tumor progress

D001932;D005909

T191

mri radiom differenti low grade glioma glioblastoma peritumor region peritumor region ptr glioblastoma gbm appear tw hyperintens compos microscop tumor edema infiltr low grade glioma lgg compris tumor cell seem similar gbm ptr mri work explor radiom base approach distinguish two group tumor edema versus tumor alon

D001932;D005909;D005910;D008279

T170;T059;T191;T060

construct pearson mic base co express network identifi potenti cancer gene weight gene co express network analysi wgcna method construct co express gene modul base linear similar pair gene express linear correl main form similar gene howev nonlinear correl still exist alway ignor propos modifi network analysi method wgcna p combin pearson correl coeffici maximum inform coeffici mic similar measur assess linear nonlinear correl gene respect take two real dataset gse liver hepatocellular carcinoma tcga lihc exampl compar gene modul construct wgcna p wgcna four perspect use score go enrich analysi gene gray modul predict perform top hub gene surviv analysi literatur report differ hub gene result show modul obtain wgcna p biolog meaning hub gene obtain wgcna p potenti cancer gene

D006528;D008113

T191

codon usag minim natur cell statist analysi variat content size current known smallest genom n deltocephalinicola c ruddii n equitan genitalium enabl indic minim set codon capabl natur build modern type free live unicellular organ earli stage evolut use linear regress model potenti codon distribut minim natur cell predict compar composit smallest synthet jcvi syn distribut molecular weight potenti code amino acid also calcul main differ featur minim natur cell h sapien genom analyz regard content percentag respect amino acid polar charg properti report compar fraction occur nucleotid calcul estim number codon minim natur cell relat expect number random distribut shown increas decreas content relat calcul random fill relat evolutionari prefer vari subsequ era evolut genet code

D000081183;D019143

T038;T045

develop predict model incid pediatr acut otiti media use poisson regress analysi xgboost otiti media profound health econom impact occurr known influenc air pollut climat purpos studi develop predict model use climat air pollut indic occurr acut otiti media aom studi conduct januari decemb includ pediatr patient age year diagnos emerg room visit tertiari medic institut obtain data week number aom patient week averag valu air pollut climat indic poisson regress analysi extrem gradient boost xgboost use develop predict model overal pediatr patient patient classifi accord sex male femal age year year overal popul correl coeffici origin estim data test set p p model develop use poisson regress analysi xgboost respect root mean squar error test set respect patient classifi accord sex age predict model develop use xgboost show better perform model develop use poisson regress analysi conclus studi success develop predict model air pollut climat indic incid pediatr aom use xgboost model develop prevent pediatr aom

D000397;D010033

T080;T069;T047

drive low carbon agricultur experi farm wielkopolska region poland global environment problem low carbon agricultur gain increas import develop develop countri henc need find way develop effici agricultur system purpos articl identifi driver low carbon agricultur farm wielkopolska region poland aim take origin approach investig low carbon agricultur uniqu set differ econom environment variabl contribut literatur extens term microeconom research includ research farmer wielkopolska region therefor employ multipl factor measur model structur equat model sem data collect individu farm result formul follow conclus increas product factor land labor capit posit effect low carbon farm increas fertil energi effici moreov thermal insul also import low carbon agricultur effici fertil use import factor believ issu farm use fertil thermal insul build broad includ energi polici nation european union eu level factor howev alreadi present common agricultur polici cap

D000383;D002244

T090;T121;T196

watch trend ozon increas decreas covid pandem restrict measur covid caus environment panorama citi chang especi relat air pollut scenario sever reduct emiss air pollut led flurri studi behavior pandem vast major studi point decreas pollut except ozon howev highlight ozon trend realli global trend discuss seek answer question address two major consider led trend process ozon format behavior main reason led find trend region studi meteorolog condit time scale adopt data collect observ emphas trend unanim global trend turn opposit initi studi show observ trend region trend affect reason discuss thus rais awar concern way initi fever behavior air pollut occur also toward act sampl high popul area attitud could caus bias estim disinform

D000393;D000397;D000086382;D010126

T080;T069;T103;T131;T047;T067

assess rheolog behaviour water oil emuls mediat glycolipid biosurfact produc bacillus megaterium spsw screen programm use miner salt medium supplement n hexadecan result isol bacillus megaterium spsw capabl produc surfac activ molecul lower cultur medium surfac tension mnm interfaci tension mnm h emulsif index e biosurfact product use assess effect rheolog characterist water oil emuls prepar engin oil structur character biosurfact product ftir reveal c c stretch sugar moieti ester carbonyl linkag group sugar fatti acid respect mass spectral analysi reveal glycolipid natur mz valu fluid behaviour water oil emuls show non newtonian viscoelast dilat flow yield exemplifi appropri herschel bulkley model confid fit present studi signific formul handl process transport emuls understand floccul characterist

D006017

T109;T123

situat bodi anorexia conflict dwell commend prof fuch analysi anorexia conflict embodi find import underlin role environ particular refer studi soon publish mention difficulti patient experi relat home

D000855

T047

system approach occup vocal health consider communiti faith leader system think approach benefit occup vocal health vocal reliant worker paper explor communiti faith leader exampl high vocal reliant occup may benefit system think use support vocal occup health safeti scope review current literatur regard faith leader occup voic use vocal health detail includ recognis occup hazard articl discuss uniqu potenti use system think facilit faith leader vocal occup health safeti rather use sole clinic perspect sociotechn system approach biopsychosoci spiritu approach note particular pertin occup group

D016272

T078;T091

role valu chaplain ambul servic paramed perspect chaplain employ ambul servic mani state across australia one element suit initi support health well paramed aim paper present key find studi explor paramed perspect role valu chaplain ambul servic seventeen paramed particip semi structur interview data analys use framework analysi two theme identifi scope chaplain role organis factor influenc chaplain role paramed high valu believ proactiv reactiv support provid ambul chaplain regardless paramed person spiritu religi belief

D002977;D004634

T097

role trpv channel osteoporosi world popul age treatment osteoporosi major problem address caus osteoporosi remain unclear ca import compon bone also play key role osteoporosi treatment transient receptor potenti vanilloid trpv channel one trp channel famili wide distribut various organ play import role physiolog regul human bodi bone format bone absorpt may requir ca transport via trpv channel proven trpv subtyp trpv trpv trpv trpv trpv may affect bone metabol balanc select regul ca signific regul osteoblastosteoclast prolifer differenti function purpos review explor mechan trpv channel involv regul differenti osteoblast osteoclast well discuss latest develop current research may provid new clue direct depth studi osteoporosi relat bone metabol diseas

D004198

T201

sensor detect cr iii fe iii ion base turn mechan fluoresc comput studi new innov fluoresc structur construct cyclotriveratrylen affili dansyl chlorid dnsc use detect cr iii fe iii among various cation use spectrofluorimetr method character new compound carri use h nmr c nmr esi ms techniqu interact role dnsc ctv cation review chang spectra absorpt direct conclus substanti interact cr iii fe iii dnsc ctv furthermor interact ligand dnsc ctv metal ion chromium iii iron iii show quench emiss spectra quantum yield complex calcul stern volmer analysi done deduc quench mechan fluoresc either static dynam molecul dnsc ctv studi help comput method molecular dock studi bind interact properti molecul

D005456

T130

risk respons rude rule loneli social distanc warrior respons obey covid rule order minim risk yet still seen rude challeng peopl respect rule fact opposit true rude increas risk other paper analys relationship risk respons rude analys evolut main government slogan rule explor complex relationship simplic safeti perceiv fair rule featur turn influenc extent act respons begin explor relationship rude risk interact coronavirus go analys import clear rule minim tension us illustr argument various slogan includ stay home stay alert infam rule six actual least three differ rule ultim face paradox peopl annoy complexunfair rule less like obey even mean rule appli longer even though noncompli earlier simpler rule mean new rule necessari rule make less sens harder tri get peopl follow capac citizen hard polic rule seen arbitrari unfair

D000086382;D000075282

T054;T047;T067

system bevacizumab facilit anticoagul antiphospholipid syndrom bleed gastrointestin angiodysplasia bleed gastrointestin angiodysplasia may occur patient vascul challeng treat describ novel use bevacizumab therapi treat bleed gastrointestin angiodysplasia sever anemia patient eosinophil granulomatosi angiiti complic antiphospholipid antibodi syndrom requir indefinit warfarin therapi studi confirm multipl bleed jejun angiodysplasia unamen endoscop intervent patient requir ongo support iron infus blood transfus maintain minim accept hemoglobin given sever anemia need continu indefinit antiplatelet anticoagul therapi failur standard treatment approach patient initi system bevacizumab therapi basi prior document success bevacizumab manag gastrointestin telangiectasia patient hereditari hemorrhag telangiectasia bevacizumab high effect rapid resolut bleed normal hemoglobin liber hematolog support advers event includ thromboembol event vascular endotheli growth factor vegf rose paradox initi bevacizumab normal discontinu given find use system bevacizumab manag bleed angiodysplasia patient acquir vascular disord merit studi

D000740;D016888;D016736

T047

fluoroscopi free ablat congenit heart diseas moder great complex fluoroscopi free ff ablat demonstr safe success patient structur normal heart systemat evalu patient congenit heart diseas chd moder great mg complex studi aim evalu compar feasibl safeti outcom ff ablat patient without mg chd

D017115;D006330

T061;T019

oro nasopharyng papilloma squamous respiratori featur case seri schneiderian like papilloma pharynx limit literatur detail histolog pharyng papilloma herein report experi papilloma occur oro nasopharynx squamous respiratori featur akin sinonas schneiderian papilloma retrospect review pharyng papilloma compos squamous respiratori epithelium receiv institut case sinonas papilloma direct extend pharynx exclud immunohistochemistri p well rna situ hybrid evalu low risk high risk hpv genotyp perform case thirteen case includ mean age male femal often incident found present symptom includ globus sensat hemoptysi hoars voic histolog tumor consist squamous respiratori epithelium neutrophil infiltr arrang exophyticpapillari architectur reminisc exophyt type schneiderian papilloma immunohistochemistri p negat papilloma posit low risk human papillomavirus hpv subtyp negat high risk hpv subtyp well differenti invas squamous cell carcinoma associ two case papilloma squamous respiratori featur similar sinonas exophyt schneiderian papilloma aris oro nasopharynx like sinonas counterpart show associ hpv mani seri benign harbing invas squamous cell carcinoma

D002294;D006258;D009303;D010212;D030361

T191;T047

vasomotor symptom midlif women incid breast cancer pink swan compar trajectori vasomotor symptom vms risk factor women breast cancer brca cancer free control

D001943

T191

effect p glycoprotein inhibit penetr ceftriaxon across blood brain barrier recent studi indic inhibit efflux transport p glycoprotein p gp blood brain barrier bbb may repres putat strategi increas bbb penetr sever antibiot therefor present studi aim investig effect p gp inhibit transport ceftriaxon cfx across bbb blood brain microdialysi rat use monitor blood brain unbound cfx concentr follow intraven administr mgkg without pretreat one p gp inhibitor cyclosporin mgkg verapamil mgkg inhibitori effect demonstr increas ratio unbound brain unbound blood concentr k puubrain cfx concentr cfx blood brain min intraven administr cfx mgkg rang gml gml respect k puubrain cfx pretreat cyclosporin increas brain concentr k puubrain cfx dose depend manner howev pretreat verapamil increas brain concentr cfx k puubrain present data show cfx might substrat p gp efflux transport bbb p gp inhibit might enhanc brain concentr cfx futur studi involv select p gp inhibitor knockout mous model conduct specif elucid impact p gp inhibit penetr cfx across bbb

D020168;D001812

T116;T023;T123

resiniferatoxin hamper nocifens respons caenorhabd elegan noxious heat pathway analysi reveal wnt signal pathway involv resiniferatoxin rtx metabolit extract euphorbia resinifera rtx potent capsaicin analog specif biolog activ result agonist activ transient receptor potenti channel vanilloid subfamili member trpv rtx examin pain reliev recent investig abil desensit cardiac sensori fiber express trpv improv chronic heart failur chf outcom use valid anim model caenorhabd elegan c elegan express ortholog vanilloid receptor activ capsaicin produc antinocicept effect thus use c elegan character antinocicept properti perform proteom profil uncov specif signal network exposur rtx wild type n mutant c elegan place petri dish divid quadrant heat stimul thermal avoid index use phenotyp test c elegan experiment group data reveal first time rtx hamper nocifens respons c elegan noxious heat c effect revers h rtx exposur addit identifi rtx target c elegan transient receptor potenti channel ocr proteom pathway enrich analysi result suggest wnt signal trigger agonist effect rtx c elegan vanilloid receptor

D017173;D004224

T204;T109

follow psychiatr care risk readmiss patient serious mental ill state fund oper facil receipt outpati treatment within day discharg psychiatr hospit establish qualiti indic howev scant mix evid whether reduc risk readmiss evalu question patient hospit schizophren bipolar depress disord use mental health treatment episod data set mh ted compris patient state fund oper facil program perform month retrospect longitudin cohort studi includ patient schizophren disord patient bipolar disord patient depress disord index hospit stratifi whether least one outpati treatment admiss first day post discharg use multivari logist regress assess risk readmiss day found less percent patient three cohort receiv recommend follow outpati care furthermor found schizophren bipolar patient receiv care less like readmit receiv care aor ci aor ci patient depress disord receiv care like readmit aor ci thus patient receiv follow outpati care within day discharg occur outpati care either link reduc readmiss associ increas readmiss find suggest need effect care process state fund oper facil

D000359;D001523

T048;T058

applic polyion magnet nanoparticl catalyst synthesi carbonitril indol triazol moieti via cooper gemin vinylog anomer base oxid three compon reaction aldehyd h indol yl oxopropanenitril h triazol amin solvent free condit c effect perform presenc mg polyion magnet nanoparticl pyrazin bridg fe sio ch pyrazinium tcm catalyst synthesi aryl h indol yl triazolo pyrimidin carbonitril via cooper anomer base oxid polyion magnet nanoparticl catalyst simpli recov reus four success run morpholog structur mnps catalyst investig numer techniqu xrd ft ir edx wdx fe sem tem tga dta vsm obtain product report first time identifi various analys techniqu melt point ft ir h nmr c nmr element analysi chn term entitl cooper gemin vinylog anomer base oxid introduc latter step reaction mechan first time synthesi aryl h indol yl triazolo pyrimidin carbonitril use fe sio ch pyrazinium tcm mnps catalyst

D058185;D014230

T121;T130;T109

mainstream except evolutionari stabil zw sex chromosom across fish famili triportheida gasteropelecida teleostei characiform teleost fish exhibit breath take divers sex determin differenti mechan encompass least nine sex chromosom system often low degre differenti high rate inter intra specif variabl frequent turnov nevertheless sever main femal heterogamet system advanc stage genet differenti high evolutionari stabil also found across teleost especi among neotrop characiform studi aim character zzzw sex chromosom system repres triportheida famili triportheus auritus agoni halecinus basal speci lignobrycon myersi sister clade gasteropelecida carnegiella strigata gasteropelecus levi thoracocharax stellatus appli convent molecular cytogenet approach includ chromosom map ribosom dna cluster cross speci chromosom paint zoo fish sex chromosom deriv probe compar genom hybrid cgh identifi zw sex chromosom system first time halecinus g levi also c strigata former report lack sex chromosom also brought evid possibl mechan under sex chromosom differenti includ invers repetit dna accumul exchang genet materi zoo fish experi strong indic zw sex chromosom triportheida gasteropelecida homeolog suggest origin split lineag approx million year ago extent sex chromosom stabil almost except teleost henc lineag afford special opportun scrutin uniqu evolutionari forc pressur shape sex chromosom evolut fish vertebr general

D060125

T013

associ tumor mutat burden immun gene express respons pd blockad sasanlimab across tumor type rout administr sasanlimab monoclon antibodi bind program cell death receptor pd anti pd monoclon antibodi improv patient clinic outcom howev treat patient deriv clinic benefit insight potenti biomark beyond pd l express level would help identifi patient like respond treatment

D060890;D009369

T116;T191;T129

pet imag vla new braf mous model melanoma despit unpreced respons immun checkpoint inhibitor target therapi melanoma major subset patient progress effect salvag option previous demonstr robust select uptak peptidomimet llpa label cu cu llpa positron emiss tomographi pet imag subcutan metastat model bf murin melanoma llpa bind high affin late antigen vla integrin transmembran protein overexpress melanoma cancer facilit tumor growth metastasi yet bf fail faith reflect human melanoma biolog lack certain oncogen driver mutat includ braf mutat found clinic specimen evalu pet tracer cu cb teap peg llpa cu llpa novel translat braf mutant melanoma model differ vla express bpr vla bpr vla

D039041;D008545

T116;T191;T192

profil naturalist attent trajectori associ intern behavior school age children mobil eye track studi tempera profil behavior inhibit bi strong predictor intern behavior childhood pattern attent toward away threat common bi intern behavior attent bias tradit measur comput task present affect stimuli lack ecolog valid recent studi suggest naturalist visual attent need mirror find comput task specif children high bi may attend less threat naturalist task character latent trajectori naturalist visual attent time femal stranger measur mobil eye track among kindergarten oversampl bi group base trajectori model gbtm reveal two latent trajectori high initi orient stranger gradual decay recoveri low initi orient continu avoid higher probabl membership avoid group link greater report intern behavior demonstr efficaci mobil eye track quantifi naturalist pattern visual attent social novelti well import naturalist measur attent character socioemot risk factor

D000070379;D000084542

T041;T073;T060

global health facil base intervent achiev unaid systemat review narrat analysi evalu whether health facil base hiv intervent align unaid target perform systemat review len unaid target search databas retriev citat elig studi classifi countri incom unaid target analyz whether report studi outcom metric line unaid target use standard extract form result summar narrat synthesi given data heterogen also assess qualiti random trial cochran risk bias tool observ studi newcastl ottawa scale stratif intervent countri incom level reveal theme success intervent provid insight scale similar resourc context studi report outcom use metric accord unaid target standard report accord unaid framework could facilit compar intervent inform countri level progress intern scale

D015658

T047

bilater central neck dissect via transor approach papillari thyroid carcinoma transor endoscop vestibular approach toetva thyroidectomi gain popular russel et al thyroid le et al surg laparosc endosc percutan tech liao et al laryngoscop toetva util success perform thyroidectomi parathyroidectomi neck dissect via endoscop robot techniqu razavi et al head neck otolaryngol head neck surg ngo et al j ent https doiorg ann surg oncol video show bilater central neck dissect via transor approach papillari thyroid carcinoma

D037981;D013964

T061;T191

extend en bloc reoper recurr persist parathyroid carcinoma analysi case singl institut experi parathyroid carcinoma pc rare malign difficult erad complet recurr assess effici extend en bloc resect eebr manag recurr persist pc

D010282

T191

associ local anesthet dose postop opioid requir pain score lumpectomi sentinel lymph node biopsi multimod analgesia multimod analgesia mma breast surgeri reduc postop pain opioid requir relat contribut local anesthet dose compon mma well defin among patient undergo lumpectomi sentinel lymph node biopsi slnb

D000698;D000779

T061;T121;T109

particip factor contribut magnet reson imag motion artifact children mild traumat brain injuri orthoped injuri motion compromis imag qualiti confound result especi pediatr research studi evalu qualit quantit approach motion artifact detect correct whether motion artifact relat injuri histori age sex children mild traumat brain injuri orthoped injuri relat typic develop children concord qualit quantit motion rate also examin children age year mild traumat brain injuri n orthoped injuri n recruit emerg depart complet mri scan rough week post injuri typic develop children n complet singl mri scan diffus weight imag visual inspect rate motion artifact train examin quantit estim motion artifact deriv freesurf fsl age younger older sex boy girl signific associ motion artifact diffus weight imag children mild traumat brain orthoped injuri signific motion corrupt diffus weight volum typic develop children mild traumat brain injuri orthoped injuri group differ exclus motion corrupt volum signific chang diffus tensor imag metric result indic autom quantit estim motion artifact less labour intens manual method appropri result implic reliabl structur mri research highlight import consid motion artifact studi pediatr mild traumat brain injuri

D016477;D001924

T068;T037

life margin host parasit relationship ecolog edg transit zone edg habitat key landscap investig biodivers soft edg permeabl corridor host cross hard edg imperm border host pass although pathogen transmiss context edg vital speci conserv driver host parasit relationship ecolog edg remain poor understood thus defin framework test hypothes host parasit interact hard soft edg character hard soft edg host parasit perspect predict type parasit would success type edg appli framework speci invas front exampl host parasit relationship soft edg general posit parasit soft edg like negat affect habitat fragment host occupi higher trophic level parasit transmiss would benefit increas host connect parasit along hard edg howev higher risk local extinct due host popul perturb limit opportun parasit recolon use characterist predict function trait would lead parasit success along soft hard edg final appli framework invas speci front highlight predict regard host connect parasit trait soft edg anticip work promot complet discuss habitat connect use common framework stimul empir research host parasit relationship within ecolog edg transit zone

D006790;D010271

T204;T070

germin develop embryon redia hemiuroid digenean bunocotyl progenetica ultrastructur studi embryon develop reproduct organ redia digenean bunocotyl progenetica studi use transmiss electron microscopi germin primordium becom morpholog distinct earli embryo weak separ cell mass form caviti consist undifferenti differenti support cell embryo develop support cell form wall around enlarg caviti cell germin primordium incorpor wall solitari cell small cell aggreg situat posterior give rise incipi germin mass function postembryon develop undifferenti differenti cell middl anterior part primordium ensur consider growth caviti wall incorpor solitari germin cell advanc embryon redia cell matur cleav give rise germin ball enter form brood caviti matur embryon redia earli cercari embryo resid brood caviti line time syncytium continu support tissu incipi germin mass base result literatur data suggest morphogenesi reproduct apparatus daughter parthenita hemiuroid digenean may character emerg incipi brood caviti within germin primordium format caviti line cell germin primordium fragment uneven distribut germin materi germin primordium around caviti anticipatori develop germin materi

D014200

T204

livestock guard dog minor effect parasit burden wild carnivor livestock guard dog increas use reduc carnivor livestock conflict inform avail determin advers effect dog may health wild carnivor assess differ preval rich sever parasit chilla fox lycalopex griseus popul associ livestock guard dog routin deworm also evalu whether parasit assemblag herd dog deworm chilla fox similar presenc livestock guard dog scat l griseus herd dog collect screen parasit egg area without livestock guard dog determin differ preval rich intens parasit aggreg find associ livestock guard dog differ parasit rich preval parasit intens parasit higher among fox posit parasit lgds present lower proport fox low parasit burden occur area lgds compar area without lgds differ signific popul level find show need continu studi effect livestock guard dog health wildlif larger sampl size locat

D004283;D010271

T204;T047

construct nomogram reveal prognost benefit spontan intracrani hemorrhag among chines adult popul base studi aim build nomogram base patient spontan intracerebr hemorrhag sich predict probabl mortal morbid day day respect

D020300;D049451

T046;T170;T081

emerg correl gene express dynam footprint resourc competit genet circuit need cellular environ oper natur coupl circuit function overal function gene regulatori network execut function gene circuit draw resourc form rna polymeras ribosom trnas recent experi point role resourc competit synthet circuit output could immens howev effect complex circuit architectur resourc share dynam yet unexplor paper employ mathemat model silico experi identifi sourc resourc trade quantifi impact function genet circuit keep focus regul immedi downstream protein often use protein read out show estim gene express dynam read downstream protein data might unreli resourc limit ribosom affin asymmetr focus impact mrna copi number ribosom bind site rbs strength nonlinear isoclin emerg two regim promin separ tip point studi correl competit domin depend various circuit paramet focus genet toggl circuit identifi major effect resourc competit model motif quantifi observ observ testabl wet lab experi paramet chosen experiment relev

D053263;D012270

T026;T044

use statist method assess groundwat contamin lower tano river basin ghana west africa studi descript statist correl matrix multipl regress model geostatist model use assess contamin groundwat respect trace element lower tano river basin ghana west africa total number borehol drill across basin depth rang use data sourc studi result descript statist show averag lead iron aluminium concentr exceed permiss limit mgl mgl mgl respect furthermor copper chromium aluminium zinc manganes nickel iron arsenic electr conduct total dissolv solid found extrem high posit skew even though signific correl exist among variabl statist result show qualiti borehol drill across basin main origin geogen anthropogen sourc addit pair correl physic paramet trace element drill borehol predict use multipl regress model likewis geostatist model use assess spatial analysi pair correl physic paramet trace element drill borehol cross valid result reveal krige model precis model spatial distribut map correl physic paramet correl trace element concentr borehol drill across studi region semivariogram model show correl physic paramet correl trace element weak moder strong spatial depend suggest fewer agronom influenc result spatial analysi consist multipl regress model pearson correl matrix

D060587;D014874

T131;T070;T081;T082

novel therapi follicular lymphoma indol non hodgkin lymphoma select therapi patient indol non hodgkin lymphoma inhl includ follicular fl margin zone mzl small lymphocyt sll lymphoplasmacyt lymphoma lpl waldenstrm macroglobulinemia wm sever factor consid median age around diagnosi mani patient accumul comorbid condit may limit treatment option although incur inhl chronic diseas median overal surviv measur year decad long natur histori chang risk benefit balanc lower accept toxic earli treatment cours compar aggress lymphoma despit recent rapid increas avail therapi overal progress inhl slow sever reason initi trial group inhl togeth make challeng appreci differenti activ among subtyp abl develop prognost model maintain valid era chemotherapi free option predict marker elus without identifi molecular signatur challeng select sequenc therapi clinic factor mind addit heterogen among within inhl standard treatment algorithm feel patient individu treatment approach review focus recent updat controversi manag inhl focus fl mzl

D016219;D000076962;D033581

T116;T061;T129;T192

outcom paediatr acut leukaemia patient admit paediatr intens care unit children acut leukaemia al high risk popul infect life threaten condit requir paediatr intens care unit picu admiss present increas mortal rate literatur exist picu outcom kind patient especi haematopoiet stem cell transplant hsct background investig clinic epidemiolog characterist patient well outcom retrospect singl centr analyticalobserv studi conduct januari decemb picu tertiari care hospit al patient day year old admit picu includ exclud histori hsct car cell therapi collect epidemiolog clinic characterist laboratori microbiolog result outcom forti three patient al requir urgent admiss lymphoblast myeloblast differ episod main reason sepsi hyperleukocytosi respiratori failur seizur nineteen requir inotrop support fifteen requir mechan ventil three patient die hospit sixti day mortal year mortal differ regard type al day mortal log rank p conclus studi main caus admiss al patient infect associ sever longer hospit admiss known acut leukaemia common childhood cancer admiss paediatr intens care unit requir children acut leukaemia regard outcom children acut leukaemia requir admiss intens care unit data scarc new mortal acut leukaemia patient admit paediatr intens care unit lower patient histori stem cell therapi higher patient solid tumour main reason admiss sepsi relat literatur sever long length stay

D015278;D015470

T093;T191;T073

chang physico mechan properti water caltrop fruit trapa natan l dri process cosmopolitan water caltrop plant trapa natan l produc nut matur process develop hard pericarp hard togeth structur shape extern spike pericarp seed water contain fruit respons mechan properti studi determin forc need break trapa natan nut various dri stage test carri week interv fruit dri complet amount forc necessari crack nut dri stage determin well work crush calcul greatest compress forc crush forc reach forc need ruptur hydrat fruit horizont plane higher necessari ruptur dri fruit experi show maximum forc need crush fruit n occur crush fruit week dri largest calcul crush work mj fruit strength paramet introduc character mechan properti water caltrop extens scope hard defin ratio compress forc increment strain increment specif crush energi defin ratio crush work water caltrop mass unit crash forc defin ratio crush forc caltrop thick paramet reach highest mean valu pericarp week desicc mass measur also appli model desicc process exponenti function dens pericarp materi reach matur slight chang dri use industri extrem durabl biodegrad biolog materi result also suggest great evolutionari success speci may result abil pericarp protect seed lead spread speci aquat environ

D005638;D014867

T197;T168;T002;T121

influenc photobiomodul therapi treatment pulmonari inflammatori condit impact covid current face pandem continu caus high death rate negat econom psychosoci impact therefor period requir quick search viabl procedur allow us use safe non invas clinic tool prophylact even adjuv method treatment covid evid show photobiomodul therapi pbmt attenu inflammatori respons reduc respiratori disord similar acut lung injuri ali complic associ infect one caus new coronavirus sar cov henc aim present studi evalu influenc pbmt infrar low level laser therapi treatment ali one main critic complic covid infect experiment model rat twenti four male wistar rat random alloc three experiment group n control group cg control ali ali acut lung injuri pbm alip treatment laser equip use nm mw j appli three site anterior region trachea ventral region thorax bilater period h induct ali treatment evalu descript histopatholog analysi lung injuri score analysi number inflammatori cell express interleukin il perform result possibl observ treatment pbmt reduc inflammatori infiltr thicken alveolar septum lung injuri score compar ali group addit pbmt show lower immunoexpress il therefor base result observ present studi conclud treatment pbmt infrar low level laser therapi abl induc adequ tissu respons capabl modul sign inflammatori process ali one main complic covid

D000086382;D028022

T061;T047;T067

effect photodynam therapi gold nanoparticl streptococcus mutan biofilm format vitro studi experiment studi aim evalu antibacteri anti biofilm effect photodynam therapi photosensit conjunct gold nanoparticl streptococcus mutan import cariogen bacteri agent experiment vitro studi evalu antibacteri anti biofilm effect five group follow mutan methylen blue mb gold nanoparticl aunp methylen blue conjug gold nanoparticl mb aunp mb mediat photodynam therapi mb mediat pdt methylen blue conjug gold nanoparticl mediat photodynam therapi mb aunp mediat pdt ingaalp laser azor k mw total output nm wavelength laser probe cross section cm use methylen blue activ total dose jcm min irradi group minimum inhibitori concentr mic minimum bactericid concentr mbc coloni form unit cfu determin bacteri biofilm format inhibit assess crystal violet stain microtit plate biofilm assay viabil mutan cell assess mtt assay mb mediat pdt mb aunp mediat pdt effect method mutan biofilm inhibit p gold nano particl mediat photodynam therapi repres antibacteri antibiofilm activ mutan modal effect routin pdt

D053768;D010778

T061;T073

assess transport mechan intraneuron stabil l carnosin l carnosin alanyl l histidin well known antioxid neuroprotector various model anim cell cultur howev plethora data demonstr effici neuroprotector distinct lack data regard mechan take neuron accord literatur cultur rat astrocyt skpt cell rat choroid plexus epitheli cell take carnosin via h coupl pept membran transport assess effect mechan carnosin transport stabil primari rat cortic cultur neuron demonstr neuron take carnosin via activ transport km maximum veloc nmolmg prot min passiv transport speed constitut nmolmg prot min concentr medium signific less activ transport speed howev carnosin concentr mm led passiv transport speed becom greater activ transport speed use pept inhibitor zofenopril demonstr pept depend transport one main mode carnosin take neuron experi demonstr incub carnosin affect pept amount present cultur time remov carnosin medium elimin speed cultur cell reach nmolmg prot min led decreas carnosin quantiti control level cultur within h thus carnosin taken neuron effect compar pept substrat elimin rate suggest effect use neuroprotector necessari either maintain high concentr brain tissu increas effect glial cell synthesi endogen carnosin shuttl neuron use stabl chemic modif carnosin

D002336;D027981

T109;T116;T121;T123

geometr shape reconstruct revis tka uka knee use gaussian process regress revis knee surgeri complic distort previous compon remov addit bone potenti caus misalign inappropri select implant studi reconstruct nativ femor tibial surfac shape simul totalunicompartment knee arthroplasti tkauka femur tibia use statist infer method base gaussian process regress compar true geometri averag absolut error mean absolut distanc predict resect femur bone tka medial uka later uka mm mm mm respect predict tibia resect correspond surgeri mm mm mm respect furthermor found predict accuraci depend size gender resect bone exampl predict accuraci uka cut signific better tka cut p femal male cut often overfit underfit respect data indic reconstruct approach viabl option plan revis surgeri especi contralater anatomi patholog avail

D003198;D007720

T074;T066

coccygectomi refractori coccygodynia systemat review meta analysi sought systemat assess summar avail literatur outcom follow coccygectomi refractori coccygodynia

D003050;D017116

T184;T023;T047

preval frailti among breast cancer patient systemat review meta analysi coexist frailti breast cancer bc relat higher risk hospit mortal fall given potenti revers frailti investig epidemiolog bc great import howev estim preval frailti bc patient vari consider synthes exist bodi literatur preval frailti among bc patient

D001943;D000073496

T046;T033;T184;T191

enhanc osteoinduct capac poli lactic co glycol acid biphas ceram scaffold embed simvastatin studi evalu effect embed simvastatin sim osteoinduct capac plga hatcp scaffold stem cell human exfoli decidu teeth shed

D010012;D019821

T042;T121;T109

e pass score system serv predictor short long term outcom gastric cancer surgeri studi aim evalu estim physiolog abil surgic stress e pass score system predict short long term outcom gastric cancer gc surgeri

D013274

T191

effect preoper long term use corticosteroid develop post transplant lymphoprolif disord lung transplant singl center experi japan post transplant lymphoprolif disord ptld major complic lung transplant ltx howev studi ptld asian popul report explor characterist japanes ptld case ltx

D020031;D016040;D008232

T061;T191;T047

protein enhanc feed esophagectomi esophag cancer attenu postop catabol prospect observ studi evalu nutrit supplement attenu postop catabol esophag cancer patient radic esophagectomi

D004938;D016629

T061;T191

use microfocus comput tomographi life scienc research preliminari studi use murin micro hepat tumor model microfocus comput tomographi micro ct wide use high radiat intens industri micro ct life scienc field preliminari studi investig potenti valu detect micro hepat tumor mous model

D001690;D008113

T090;T191

laparoscop iliopub tract repair treat recurr pediatr inguin hernia congenit defect open processus vaginali canal nuck common caus primari pediatr inguin hernia pih howev patient pih occur via acquir defect rather congenit defect repres caus pih recurr hernia recurr pih treat high ligat hl method use treat primari pih howev recurr rate recurr pih high studi aim compar laparoscop iliopub tract repair iptr laparoscop hl treatment recurr pih primari pih repair

D006552;D010535

T190;T061;T060;T047

nerv autofluoresc near ultraviolet light cut edg technolog intra oper neural tissu visual patient nerv visual identif neural tissu surgeri crucial numer reason includ prevent iatrogen nerv neural structur injuri facilit nerv repair howev current method intra oper nerv detect general expens unproven andor technic challeng recent document vivo anim model ex vivo human tissu nerv autofluoresc view near ultraviolet light nuv paper describ use nerv autofluoresc facilit visual nerv neural tissu intra oper patient undergo rang surgic procedur

D013965;D014466

T070;T061

return sweep saccad oral read recent research return sweep saccad improv understand eye movement read paragraph howev saccad take gaze end one line start next line studi within context silent read articulatori demand coordin eye voic span ev line boundari suggest execut saccad may differ oral read compar launch land posit return sweep correct saccad probabl fixat adjac return sweep skill adult reader read paragraph aloud silent compar silent read return sweep launch closer end line land closer start next line read aloud probabl make correct saccad higher oral read silent read indic oral read may compel reader reli foveal process expens parafov process found interact read modal fixat type fixat durat read modal effect ie increas fixat durat oral compar silent read greater accur line initi fixat margin greater line final fixat compar intra line fixat suggest reader may use fixat adjac return sweep natur paus locat modul ev

D011932;D012438

T056;T033

effect environment condit leaf area index chang season variat carbon flux wheat maiz cropland rotat environment condit ev chang affect tempor variat carbon flux direct affect indirect impact plant biotic trait investig extent effect ev biotic chang help deepen understand ecosystem carbon cycl therefor partit quantifi contribut ev biotic chang effect season variat carbon flux net ecosystem carbon exchang nee compon ie gross ecosystem carbon exchang gee ecosystem respir winter wheat summer maiz rotat ecosystem path analysi accompani granger causal test gcts filter sever variabl causal depend variabl use calcul respect contribut integr path coeffici season variat nee gee signific joint affect ev leaf area index lai r valu rang gct path analysi indic season variat carbon flux domin effect ev chang induc vari ev differ flux crop year contribut mean two year wheat nee gee respect maiz nee gee respect overal studi provid new basi futur climat chang may import impact carbon exchang rotat cropland

D014908;D003313

T168;T002

genom analysi polyamin biosynthesi pathway duckwe spirodela polyrhiza l presenc arginin decarboxylas pathway absenc ornithin decarboxylas pathway respons abiot stress identif polyamin biosynthet pathway gene duckwe polyrhiza reveal presenc prokaryot well land plant type adc pathway absenc odc encod gene differenti gene express transcript abund shown modul exogen methyl jasmon salin acid ph genet compon encod polyamin pa biosynthet pathway known sever land plant speci howev littl known aquat plant util recent sequenc three duckwe spirodela polyrhiza genom assembl map pa biosynthet pathway gene polyrhiza pa biosynthesi higher plant except arabidopsi involv two pathway via arginin decarboxylas adc ornithin decarboxylas odc adc mediat pa biosynthet pathway gene name one arginas sparg two arginin decarboxylas spadc spadc one agmatin iminohydrolasedeiminas spaih one n carbamoyl putrescin amidas spcpa three adenosylmethionin decarboxylas spsamdc one spermidin synthas spspds one spermin synthas spspms polyrhiza genom identifi howev locus found odc pathway gene duckwe hidden markov model protein domain analysi establish spadc prokaryoticbiodegrad type adc molecular phylogen classif fell separ prokaryot origin adc clade spadc biosynthet type arginin decarboxylas howev thermospermin synthas spms aculi gene found present instead one annot spds may also function spms sinc found associ spms phylogenet clade along known spms gene moreov demonstr polyrhiza pa biosynthet gene transcript differenti express respons unfavor condit exogen ad salt methyl jasmon acid ph environ well extrem temperatur regim thus polyrhiza genom encod complet polyamin biosynthesi pathway gene transcript activ respons chang environment condit suggest import role polyamin aquat plant

D029064;D002262

T116;T002;T126

high variabl mercuri content hair russia northwest popul role environ social factor purpos work studi mercuri level hair differ social demograph group popul vologda region northwest russia region select due heterogen distribut river lake resourc base fish

D008628

T131;T196

placent human higher primat placent human precoci high invas compar mammal implant interstiti conceptus becom complet embed within endometrium toward end second week post fertil villi initi form entir surfac chorion sac stimul histotroph secret endometri gland secondari yolk sac never make contact chorion choriovitellin placenta never establish howev recent morpholog transcriptom analys suggest yolk sac play import role uptak nutrient coelom fluid measur perform vivo demonstr earli develop take place physiolog low oxygen environ protect teratogen free radic maintain stem cell multipot state matern arteri circul placenta fulli establish around week gestat villi regress superfici abembryon pole leav definit discoid placenta villous hemochori type remodel matern spiral arteri essenti ensur high volum low veloc inflow matur placenta extravil trophoblast cell migrat anchor villi surround arteri interact matern immun cell releas cytokin proteas key remodel success pregnanc

D010920;D010929

T042;T018

develop mous placenta placenta form momentari organ insid uterus slew activ woman pregnant discoid shape hybrid structur consist matern embryon compon develop mesometri side uterus follow blastocyst implant keep two genet differ entiti mother embryo separ connect begin progress placent format develop follow blastocyst implant coincid chronolog development stage embryo gradual acquir abil perform vascular respiratori hepat renal endocrin gastrointestin immun physic barrier function synchron vital fetal develop growth safeti insid matern environ uterus eject placenta embryon growth surviv support role finish usual birth babi despit irreplac role fetal develop surviv post implant progress pregnanc still remain unclear form matur perform activ start fail function thus detail understand normal development structur function aspect placenta may lead avoid pregnanc problem aris placenta

D010064;D010920

T040;T018

placent african eleph loxodonta africana femal eleph show week follicular phase commenc week estrous cycl end second surg pituitari lutein hormon lh releas matur ovul ovarian follicl associ estrous behavior mate wherea first lh surg start follicular phase caus lutein partial develop follicl prolong pregnanc month support zonari endotheliochori placenta secret placent lactogen epl around day gestat associ replac lumen epithelium endometrium trophoblast develop larg corpora lutea cls matern ovari previous form lutein follicl respons first lh peak earli follicular phase zonari placenta develop rather within endometrium eleph placenta secret neither estrogen progestagen throughout gestat pregnanc mainten reli dihyroprogesteron reduc progestagen secret secondari cls stimul epl stromal tissu fetal gonad becom extrem enlarg second half month pregnanc femal fetus ovarian enlarg includ develop subsequ regress multipl primari secondari follicl consequ substanti declin primari follicl number birth next year pre pubert life howev oocyt primari follicl number recov level near found late gestat may evid postnat oogenesi occur eleph

D004606;D010929

T042;T015

canin endotheliochori placenta morpho function aspect domest dog placent aris central implant pass transit yet import stage choriovitellin placenta yolk sac placenta way format definit decidu zonari girdl allantochorion endotheliochori placentashar similar invas type placent eg reveal decidu character restrict shallow invas trophoblast affect matern capillari matern decidu cell thus structur function place noninvas epitheliochori placent invas hemochori type present interest import model understand evolutionarili determin aspect mammalian placent profound insight biolog mechan under restrict invas fetal trophoblast matern uterin structur role decidu cell process could provid better understand advers condit occur human like preeclampsia placenta accreta import endocrin organ activ respond ovarian steroid produc hormon eg serv sourc gestat relaxin prepartum prostaglandin canin placenta becom attract research target basic clinic research particular placent feto matern communic matern stroma deriv decidu cell fetal trophoblast cell ie interplay placenta materna placenta fetali mainten termin canin pregnanc serv interest model induct parturit mammal attract subject translat compar research updat view morpho function aspect associ canin placent present

D010920;D010929

T042;T018

implant placent rumin comparison mani mammalian speci rumin ungul uniqu form placent rumin initi display epitheliochori type placent howev period placent attach trophoblast giant binucl cell bnc develop within chorion migrat fuse uterin surfac epithelium form syncyti plaqu binucl cell migrat fusion continu throughout pregnanc never appear breach basal lamina beneath uterin surfac lumin epithelium therefor semi invas type placent rumin classifi synepitheliochori endometrium rumin speci also contain uniqu special aglandular structur term caruncl chorioallantoi cotyledon interdigit form high vascular fetal matern placentom chapter discuss current knowledg earli conceptus develop peri attach period establish pregnanc conceptus attach placent rumin ungul featur placentom bncs fetomatern hybrid cell multinucl syncyti plaqu cotyledonari placenta rumin speci review highlight uniqu form placent compar placenta artiodactyl

D010920;D010929

T042;T018

placent equid chapter focus earli stage placent develop hors relat genus equus highlight uniqu featur equid reproduct biolog equin placenta classifi noninvas epitheliochori type howev equid evolv minor compon invas trophoblast chorion girdl endometri cup link equin placenta high invas hemochori placenta rodent particular primat placenta two type fetus mother signal equin pregnanc mediat invas equin trophoblast cell first endocrinolog signal mediat equin chorion gonadotrophin ecg drive matern progesteron product support equin conceptus day gestat primat equid placenta produc gonadotrophin evolutionari path taken two group mammal produc placent signal differ second florid express patern major histocompat complex mhc class molecul invad chorion girdl cell stimul strong matern anti fetal antibodi respons may play role develop immunolog toler protect conceptus destruct matern immun system human invas extravil trophoblast also express mhc class molecul loci involv like function differ hors comparison cellular molecular event dispar speci provid outstand exampl converg evolut co option mammalian pregnanc highlight studi equin placenta produc new insight reproduct strategi

D010920;D010929

T042;T018

earli stage implant placent pig pregnanc pig includ event conceptus embryofetus placent membran elong implant placent placent pig defin microscop epitheliochori macroscop diffus general placent defin juxtaposit endometrialuterin microvasculatur chorioallantoicplacent microvasculatur facilit transport nutrient mother fetus support fetal develop growth establish epitheliochori placent pig achiev secret uterin gland prior conceptus attach uterus develop extens fold uterin placent interfac maxim surfac area movement nutrient across surfac increas angiogenesi vasculatur deliv uterin placent blood nutrient interfac minim connect tissu lie blood vessel uterin placent epithelia interdigit microvilli uterin placent epithelia secret uterin gland call histotroph accumul areola transport though placenta fetus placent pig achiev invas growth placenta uterus chapter summar current knowledg major event occur earli stage implant placent pig focus microanatomi porcin placent build excel histolog work amoroso other provid brief review key physiolog cellular molecular event accompani develop implant pig

D010920;D010929

T042;T018

placent marsupi sometim impli marsupi aplacent presumpt mammal placenta eponym placent mammal misconcept persist despit interest descript marsupi placenta even amoroso definit chapter also said marsupi matern recognit pregnanc placent hormon product addit thought genom imprint could exist marsupi pregnanc short know none idea held true extens studi last four decad definit show inde mammal fulli function placenta special

D008394;D010929

T042;T015

develop pre implant mammalian blastocyst preimplant mammalian embryo simplist self contain superior model investig inher complex cell fate decis mechan mammal begin humbl journey singl cell fertil zygot contain within proteinac coat call zona pellucida zygot embark seri well orchestr event begin activ embryon genom transit meiotic mitot divis spatial organ cell time differenti commit trophectoderm te primit endoderm pre ultim escap zona pellucida implant uterus entir develop preimplant embryo studi vitro use minimalist defin cultur system eas cultur along abil manipul gene express imag embryo make ideal model system investig first two sever cell fate decis made embryo result pluripot epiblast epi differenti te pre lineag chapter review latest knowledg preimplant embryo develop set stage understand placent develop subsequ chapter book

D001755;D010920

T018

evolut vivipar vertebr vertebr tree life vivipar live birth independ evolv mani time result rich divers reproduct strategi vivipar believ mode reproduct evolv ancestr condit ovipar egg lay fetal develop occur outsid bodi today simpl model pariti transit explain speci specif diverg mode reproduct evid point gradual seri evolutionari adapt account phenomenon reproduct eleg display various vivipar squamat exhibit placenta form apposit matern embryon tissu share signific homolog tissu form placenta therian mammal era genom mani vertebr speci becom avail studi explor molecular basi transit ovipar vivipar rare instanc possibl revers australian three to skink saipho equali contrast pariti divers squamat mammal vivipar notabl except egg lay monotrem advanc comput tool coupl increas genom avail across speci util differ reproduct strategi promis reveal molecular underpin ancestr transit ovipar vivipar result dramat chang reproduct physiolog anatomi accompani pariti chang reinterpret chapter briefli explor vertebr mode reproduct use phylogenet framework possibl highlight role potenti candid gene may help explain polygen origin live birth

D008116;D052286

T042;T014

mammalian placent tribut ec amoroso contribut placenta develop establish vivipar mammal evolv long term retain fetus within matern uterus differenti expans cell layer form function membran exchang co nutrient placenta matern circul develop fetal placent vascular circul interact matern uterus critic surviv speci howev fascin mammalian placenta robust variat type form attach invas structur cell differenti endocrin function regul matern immun system despit obvious role placenta support fetal develop mammal evolv multipl strategi give live birth term placenta matern fetal interfac pregnanc quit simpl complex professor ec amoroso contribut great studi compar placent anim paper placent marshal physiolog reproduct publish remain standard compar placent anatomi today present volum mammalian placent bring togeth current review lead expert divers placent number mammalian speci chapter discuss vivipar blastocyst format placent cow pig hors mous dog primat human eleph marsupi

D008394;D010929

T042;T015

radioact level relat geolog substrat dynam natur artifici radionuclid teucrium montanum l lamiacea habitat result compar ecolog studi radionuclid activ concentr plant soil relat geolog substrat present research encompass compar analysi concentr four radionuclid three natur k ra th one artifici cs soil sampl aerial plant part teucrium montanum differ natur habitat serpentinit calcar geolog substrat activ concentr radionuclid measur high puriti germanium hpge detector express bq kg calcul activ concentr k ra th cs soil sampl serpentinitecalcar habitat rang bq kg respect activ concentr k ra th cs plant sampl rang nd nd bq kg respect obtain result show quantiti cs greater soil plant materi serpentinit habitat quantiti k ra th greater soil plant materi calcar habitat general level radioact plant soil depend type geolog substrat content radionuclid plant correl radionuclid content soil addit specif physic chemic properti serpentinit habitat character increas amount cs soil caus increas amount radionuclid plant teucrium montanum

D019686;D011851;D012990;D031367

T131;T070;T002