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34,694,747 | character astrocyt morpholog function use fast reliabl tissu clear techniqu astrocyt process interact synaps throughout brain modul neurotransmitt signal synapt communic condit exposur drug abus neurolog diseas astrocyt respond alter morpholog function properti reactiv astrocyt phenotyp exhibit bushi morpholog alter soma volum increas number process compar rest astrocyt reactiv astrocyt phenotyp also overexpress protein one glial fibrillari acid protein gfap fluoresc microscopi thin tissu section requir reconstruct often multipl section delin full astrocyt morpholog contrast tissu clear method develop enabl imag larger section includ whole brain provid opportun see depth chang singl cell structur articl detail protocol studi astrocyt morpholog use tissu clear subsequ imag whole brain well region specif slice provid method ideal understand effect differ physiolog condit astrocyt morpholog standard biochemistri laboratori resourc accomplish tissu clear use protocol univers requir imag facil protocol studi brain genet modifi mice contain astrocyt specif marker wild type mice use antibodi label step tissu clear provid also describ general protocol conduct fluoresc imag astrocyt clear tissu character morpholog protocol could use research work rapid grow field astrocyt biolog wiley period llc basic protocol brain perfus fixat tissu clear altern protocol clear brain tissu passiv clariti basic protocol antibodi label refract index match basic protocol fluoresc imag character astrocyt morpholog | D001253;D002490 | T025;T022 |
34,694,745 | rapid sensit method separ cu ion industri wastewat sampl water sampl methacrylamid ethylen glycol dimethacryl new synthesi molecular imprint polym studi new molecular imprint polym particl mip synthesis extract cu ion aqueous solut use radic polymeris mip develop use methacrylamid ethylen glycol dimethacryl egdma cross link agent methacrylamid monom acv initi radic polymeris method comparison various cross link agent mip product show best cross link agent egdma gallic acid templat ion remov leach hcl polym particl characteris ftir spectroscopi thermogravimetr analysi tga scan electron microscopi sem effect differ paramet cross linker ph time maximum adsorpt capac kinet isotherm adsorpt investig best condit determin ph min q mg g adsorpt data best fit freundlich isotherm pseudo second order kinet model well due high adsorpt capac multi layer behaviour method easi fast safe way extract cation remov cu certifi tap water rain water demonstr industri wastewat sampl charmshahr iran mip develop use methacrylamid ethylen glycol dimethacryl egdma good enough cu determin matric contain compon similar chemic properti co zn fe | D054802;D000082582 | T063;T122 |
34,694,744 | develop immunobiolog evalu nanoparticl contain immunodomin epitop herp simplex virus herp simplex virus hsv virus infect individu worldwid cure vaccin avail protect respons herp most mediat cd lymphocyt respond immunodomin ssiefarl epitop howev obstacl concern use free ssiefarl vaccin immunotherapi aim studi evalu feasibl nanoencapsul ssiefarl immunostimulatori properti nanossiefarl produc interfaci polymer methylmetacryl physico chemic properti morpholog immunobiolog paramet evalu evalu ex vivo capac nanossiefarl use splenocyt hsv infect mice enhanc frequenc ssiefarl specif cd lymphocyt result indic nanossiefarl spheric shape averag diamet nm pdi negat charg stabil c day also nanossiefarl toxic cell low concentr vitro taken jaw ii dendrit cell histopatholog chang observ kidney liver lymph node anim treat nanossiefarl nanssiefarl increas product il tnf il dendrit cell final nanossiefarl expand frequenc ssiefarl specif cdt lymphocyt rate free ssiefarl conclus data togeth indic ssiefarl suitabl nanoencapsul system produc present immunoadjuv properti use improv immun respons herp | D018259;D053758 | T005;T073 |
34,694,743 | nano bio surfac interact cellular internalis cancer cell e data portal nanomateri review nanomateri nms abund applic area electron energi environ industri biosensor nano devic theranost platform etc nanoparticl increas solubl stabil drug load materi enhanc internalis protect initi destruct biolog system lengthen circul time biolog interact protein present bodi fluid nms chang activ natur surfac properti nms size charg nms properti coat uncoat nms natur protein cellular interact direct internalis pathway cellular system thus present review emphasis impact coat uncoat nms size charg natur protein nano bio surfac interact internalis specif focus cancer cell increas activ nps may also result toxic health environ thus emphasi given assess toxic nms medic field e data share portal nms also discuss review help provid inform chemic physic biolog properti toxic nms | D053758;D049329;D009369 | T191;T073 |
34,694,742 | assess antiprolif effect biogen silver chlorid nanoparticl glioblastoma cell line quantit imag base analysi glioblastoma life threaten tumour central nervous system temozolomid tmz first choic oral drug treatment glioblastoma although show low efficaci silver nanoparticl agnp shown exhibit biocid activ varieti microorgan includ pathogen microorgan herein antiprolif effect agcl nps glioblastoma cell line gbm gbm astrocyt evalu autom quantit imag base analysi hca cell cell treat gml agcl nps gml tmz cell receiv combin treatment also analys maximum test concentr agcl nps gbm gbm growth decreas respect follow h treatment tmz treatment decreas prolifer gbm gbm cell respect combin agcl nps tmz show intermedi antiprolif effect lowest concentr caus inhibit similar obtain tmz highest concentr caus inhibit similar obtain agcl nps alon signific chang astrocyt prolifer observ author find show hca fast reliabl approach use evalu antiprolif effect nanoparticl singl cell level agcl nps promis agent glioblastoma treatment | D005909;D053768 | T191;T073 |
34,694,741 | earli late effect absorb poli vinyl alcohol hernia mesh tissu reconstruct hernia defect abdomin wall treatment princip surgic mesh implant non degrad surgic mesh produc numer complic side effect inflammatori respons mesh migrat chronic pain contrast biodegrad poli vinyl alcohol pva base polym excel chemic mechan biolog properti degrad chronic pain expect toxicolog pva solut fiber investig human dermal fibroblast adult cell line implant test observ long term contact rat larg anim swine model measur adhes format diamond vandendael score use macroscop histolog respons grade sampl vitro examin show pva solut fiber biocompat cell accord implant test sampl integr surround tissu foreign bodi reaction averag number adhes found non absorb sutur line biocompat pva nanofib mesh demonstr non adhes non toxic good qualiti structur potenti altern solut part hernia mesh | D011142;D013526 | T121;T122;T074;T109 |
34,694,740 | analysi size reduct agnp load hydrogel effect anti bacteri activ articl analys effect size reduc silver ag load hydrogel lyophilis b ball mill techniqu effect anti bacteri activ g load hydrogel show increas swell increas ph swell ag load hydrogel low ph ph swell ratio ag load hydrogel almost show less swell anti bacteri studi reveal ag load hydrogel react well aureus staphylococcus aureus zone format seen wherea zone form e coli escherichia coli next step anti bacteri activ ag load hydrogel addit curcumin cs size reduc lyophilis cs size reduc ball mill turmer ts size reduc lyophilis ts size reduc ball mill investig case ecoli zonal format cm ts cm ts cm cs cm cs observ saureus cm seen ts cs ts cs show zone format studi clear show size reduct lyophilis ts cs effici case compar ball mill techniqu ts cs compar ts cs ts high efficienteffect anti bacteri properti cs therefor lyophilis hydrogel incorpor turmer silver ts excel choic compar use curcumin wound dress applic | D020100;D053768 | T122;T073 |
34,694,739 | magnet nanobiosorb mg chife dispers solid phase extract cu ii pb ii cd ii follow flame atom absorpt spectrometri determin trace amount cu ii pb ii cd ii wastewat sampl preconcentr novel cross link magnet chitosan modifi new synthesis methionin glutaraldehyd schiff base mg chife dispers solid phase extract dspe adsorb adsorb metal ion elut specif volum suitabl solut determin flame atom absorpt spectrometri faa various paramet affect extract effici metal ion investig optimis includ ph amount adsorb extract time type volum rate eluent elut time sampl volum effect interf ion adsorpt kinet consist pseudo second order model result statist interpret analyt perform propos method found preconcentr factor g l cu ii pb ii cd ii respect limit detect g l cu ii pb ii cd ii respect relat standard deviat liner rang cu ii pb ii cd ii conclud method suitabl success simultan determin cu ii pb ii cd ii industri wastewat sampl | D002104;D014874 | T131;T196 |
34,694,738 | identif ad f mda pentyl mda seiz materi class wide ban synthet cannabinoid china curb manufactur traffick abus synthet cannabinoid china implement class wide regul synthet cannabinoid juli recent three differ type synthet cannabinoid analog cover generic definit detect seiz powder e liquid materi deriv includ fluorobenzyl h indol yl acetamido dimethylbutanamid ad n fluoropentyl oxoindolin yliden benzohydrazid f mda n oxo pentylindolin yliden benzohydrazid pentyl mda identif base ultra high perform liquid chromatographi quadrupol time flight mass spectrometri uhplc qtof ms gas chromatographi mass spectrometri gc ms nuclear magnet reson spectroscopi nmr fourier transform infrar spectroscopi ft ir ad methylen analog adb fubica chemic pharmacolog data ad f mda appear make first report two compound pentyl mda previous report high affin cannabinoid cb cb receptor first report presenc recreat drug market moreov collis induc dissoci cid electron ionize ei characterist fragment rout ad two mda deriv also discuss facilit forens laboratori identif substanc similar structur case work | D002186;D013287 | T131;T121;T109 |
34,694,735 | influenc hyaluronan densiti behavior breast cancer cell differ cd express molecular gradient common biosystem play essenti role physiolog patholog process carcinogenesi exampl hyaluronan ha homeostasi dysregul cancer cell alter synthesi degrad process result format ha gradient within tumor microenviron herein platform develop studi biolog role ha gradient breast cancer cell cell differ aggress express cd main ha receptor usual overexpress breast cancer select studi develop platform compat sever imag modal allow assess cell densiti morpholog cd express cell motil function ha densiti use high throughput analysi shown cell express cd chang along gradient cd posit cell respond differ ha gradient depend level cd express ha densiti differ respons associ activ differ signal pathway cd ha interact | D001943;D018960;D006820 | T122;T129;T121;T191;T123;T109;T116;T192 |
34,694,733 | cardiac testicular alter induc acut exposur titanium dioxid nanoparticl histopatholog studi titanium dioxid nanoparticl tio nps novel applic use mani household applic nanomedicin agricultur industri pharmaceut product applic may accompani potenti risk human health ecosystem current studi carri find acut damag might induc tio nps heart testi three group wistar albino rat rattus norvegicus subject singl dose tio nps mgkg bw cardiac testicular biopsi anim studi handl histolog histochem examin rat expos tio nps demonstr follow cardiac alter myofibr wavi appear myofibr disarray partial cross striation cardiomyocyt hydrop degener togeth vacuol nuclear alter moreov acut exposur tio nps induc follow testicular alter spermatocyt degener spermatid slough interstiti edema present cardiac testicular alter dose depend find present studi might conclud tio nanomateri capabl induc acut cardiac testicular damag dose depend could advers affect function vital organ | D053768;D053758 | T073 |
34,694,732 | formul optimis lamivudin load eudragit polym coat pectin microspher colon specif deliveri investig find prolong delay drug releas system exclus treatment hepat b reduc side effect aris convent solid dose form administ pursu goal lamivudin load eudragit coat pectin microspher formul employ wateroil wo emuls evapor strategi formul optimis use factori design drug polym ratio surfact ml volum ml process medium stir speed rpm found optim paramet obtain lamivudin load eudragit coat pectin microspher formul high drug entrap effici vitro releas kinet lamivudin suitabl fit higuchi model indic diffus control releas anomal transport obtain microspher subject differ characteris studi includ scan electron microscopi sem fourier transform infrar spectroscopi ftir differenti scan calorimetri dsc x ray diffract xrd result studi clear indic eudragit coat pectin microspher could promis control releas carrier colon specif deliveri lamivudin presenc rat cecal content | D019259;D010368 | T109;T121;T114;T123 |
34,694,731 | graphen oxid ellag acid nanocomposit effect anticanc antimicrobi agent studi ellag acid ela skin anticanc drug cap surfac functionalis graphen oxid go nano sheet electrostat stake interact prepar ela go nanocomposit thorough characteris use eight techniqu fourier transform infrar spectroscopi ftir zeta potenti x ray diffract xrd thermogravimetr analysi tga raman spectroscopi atom forc microscopi afm topograph imag transmiss electron microscopi tem surfac morpholog via scan electron microscopi sem furthermor ela drug load releas behaviour ela go nanocomposit studi ela go nanocomposit uniform size distribut averag nm high drug load capac wt vitro drug releas behaviour ela nanocomposit investig uv vis spectrometri wavelength max nm data confirm prolong ela releas min physiolog ph final ic ela go nanocomposit found gml b cell line ela go show cytotox effect gml cell line | D000890;D006108;D053761 | T121;T073;T196;T109 |
34,694,730 | nanoparticl elicitor harvest econom import secondari metabolit higher plant review nanoparticl possess uniqu properti improv biochem reactiv plant due stationari natur constant expos nanoparticl present environ act abiot stress agent sub toxic concentr phytotox agent higher concentr general nanoparticl exert toxicolog effect generat reactiv oxygen speci plant respond activ enzymat non enzymat anti oxid defenc mechan one import manifest defenc respons increas de novo biosynthesi secondari metabolit mani commerci applic present review extens summar current knowledg applic differ metal non metal carbon base nanoparticl elicitor econom import secondari metabolit differ plant vivo vitro elicit secondari metabolit nanoparticl plant cultur includ hairi root cultur discuss anoth emerg technolog ligand harvest secondari metabolit use surfac function nanoparticl also mention brief explan mechan action nanoparticl plant secondari metabol includ optimum condit paramet evalu standard success commerci exploit technolog also mention | D053758;D010944 | T002;T073 |
34,694,729 | chip label free imped base detect antibiot permeat biosensor analyt tool use analysi biomateri sampl provid understand biocomposit structur function biomolecul andor biomechan convert biolog respons electr andor optic signal particular rise antibiot resist amongst pathogen bacteria studi antibiot activ transport across cell membran field biosensor gain widespread import herein rapid label free detect antibiot permeat across membran microelectrod integr microfluid devic present integr chip consist polydimethylsiloxan base microfluid channel bond onto microelectrod glass enabl us recogn antibiot permeat across membran model membran base electr imped measur also allow optic monitor imped test label free therefor allow detect fluoresc non fluoresc antibiot model membran giant unilamellar vesicl guv use imped measur perform precis induct capacit resist metr measur signal record devic use determin chang concentr insid outsid guv found permeat antibiot molecul easili monitor time use propos integr devic result also show clear differ bilay permeat occur lipid bilay porin mediat permeat porin channel insert lipid bilay | D000900;D046210 | T195;T059;T121 |
34,694,728 | direct super hydrophob cellulos nanofiberpolyvinyl alcoholmontmorillonit aerogel green absorb oilwat separ nowaday problem oil spill organ solvent pollut becom serious develop green effici treatment method becom research hotspot herein prepar porous super hydrophob aerogel direct freez cellulos nanofibr cnf base materi polyvinyl alcohol pva cross link agent montmorillonit mmt modifi filler follow hydrophob treatment chemic vapour deposit report prepar composit aerogel present three dimension inter perfor network structur low densiti mgcm high poros good hydrophob water contact angl notabl composit aerogel good adsorpt effect differ oil organ solut adsorpt capac reach time initi weight complet adsorpt aerogel could easili collect import composit aerogel high strength whose compress stress strain reach mpa could bear time weight without deform week new green simpl effici absorb adsorpt oil organ solvent provid | D057139 | T073 |
34,694,727 | nanomicell type properti applic drug deliveri nanomicell self assembl nanos usual particl size within rang nm colloid dispers hydrophob core hydrophil shell owe size solubl customis surfac exposur environ nanomicell show uniqu novel characterist make multifunct thus make use indispens biomed applic various field review present uniqu properti nanomicell make differ particl pave way use drug deliveri agent mani biolog use applic also emphasis drug encapsul abil nanomicell differ techniqu drug load deliveri along advantag disadvantag | D008823;D053758 | T073;T109 |
34,694,726 | phyto fabric purif characteris optimis biolog compet nano silver publish studi indic virtual kind botan materi exploit make biocompat safe cost effect silver nanoparticl hypothesi support fact plant possess activ bio ingredi function power reduc coat agent ag respect phytomedi method provid favour monodispers crystallin spheric particl easili purifi ultra centrifug howev characterist particl depend reaction condit optim reaction condit observ differ experi c ph green silver nanoparticl agnp remark physic chemic optic biolog properti research find reveal versatil silver particl rang exploit topic antimicrobi ointment vivo prostheticorgan implant advanc research biogen silver nanoparticl led develop sophist optic electron materi improv effici compact configur far eco toxic nanoparticl big challeng reliabl method improv toxic report therefor need reliabl model evalu effect nanoparticl live organ | D053768;D012834 | T073;T196 |
34,694,725 | applic copper silver nanoparticl wheat plant induc drought toler increas yield drought advers affect yield qualiti nutrit valu crop plant addit caus unrest societi econom loss farmer govern present studi involv applic nanoparticl induc drought toler improv yield wheat triticum aestivum l plant green chemic method use synthesi silver nanoparticl agnp copper nanoparticl cunp cunp use mgl mgl agnp test bar osmot potenti laboratori experi field capac fc glasshous experi maintain solut cultur experi reveal signific higher chlorophyl stabil index csi leaf succul ls leaf k lk content plant treat mgl cunp mgl agnp indic posit role cunp agnp drought toler wheat similar trend observ stomat conduct sc morpholog paramet applic cu ag nanoparticl differ level field capac result studi provid experiment evid use cunp agnp induc drought resist improv yield wheat plant satisfactori increas nutrient uptak water retent | D053768;D014908 | T168;T002;T073 |
34,694,724 | surfac modifi nanosilica chitinas sinp chs dope nano enzym conjug synergist pesticid activ plant extract armyworm spodoptera litura fab lepidoptera noctuida laboratori experi conduct evalu enhanc pesticid activ silica nanoparticl dope chitinas nano enzym conjug econom import insect pest spodoptera litura fab lepidoptera noctuida silica nanoparticl synthes hydrolysi condens precursor tetraethylorthosil teo follow function function agent aminopropyltriethoxysilan function silica nanoparticl thus acquir dope chitinas enzym produc serratia marcescen su dope nanosilica chitinas nano enzym conjug load pesticid plant extract studi improv pesticid activ synthes nano enzym conjug reveal high stabl monodispers spheric nanoparticl exhibit effect load respect plant extract nano enzym conjug plant extract load nano enzym conjug record high rate mortal larval instar brought distinct effect life stage paramet slitura non target toxic effect nano enzym conjug carri determin lethal chang protein profil brine shrimp artemia salina show less lethal distinct chang protein profil suggest effect util silica nanoparticl dope chitinas insecticid agent econom import insect pest associ various crop | D002688;D010575 | T131;T116;T126 |
34,694,723 | novel brain target plasma exosom enhanc neuroprotect efficaci edaravon ischem stroke ischem stroke often involv excess product reactiv oxygen speci ros aggrav ischem injuri edaravon edv effici free radic scaveng demonstr effect neuroprotect effect therapi ischem stroke although edv promot ischem recoveri inhibit generat ros poor safeti bioavail limit clinic applic herein develop plasma exosom exo contain edv exo edv improv short term function histolog outcom stroke treatment result show exo edv improv brain target base transferrin transferrin receptor interact safeti bioavail edv also signific increas furthermor compar edv exo edv signific rescu ischem damag brain tissu reduc infarct area improv neurolog perform acut stage stroke first day | D002545;D055354;D000083242;D020521 | T046;T026;T047 |
34,694,722 | influenc seed coat copper iron zinc nanoparticl growth yield tomato neutral nanoparticl nps copper cu iron fe zinc zn wide use agricultur polym seed coat differ metal nps may suppli import nutrient plant growth consequ enhanc yield research three kind metal nps conduct optim optim concentr seed coat improv plant growth product tomato seed venic tomato cultivar coat polym base mixtur differ concentr cu fe zn nps respect harvest seed germin internod length averag weight singl fruit yield fruit shape index measur compar control internod length increas low concentr fe nps zn nps respect averag weight per fruit improv control low concentr cu nps fe nps respect yield low concentr cu nps fe nps increas yield compar control result indic polym seed coat low concentr metal nps may promot uptak nutrient thus improv product tomato | D018551;D053768;D053758 | T168;T002;T073 |
34,694,721 | design aminophenol graft polym modifi zinc sulphid nanoparticl drug deliveri system zinc sulphid zns nanoparticl synthes coprecipit method zns nanoparticl surfac polymer allyl glycidyl ether age aminophenol deposit ligand nanosorb modifi nanosorb investig fourier transform infrar spectroscopi thermogravimetr analysi particl size modifi nanosorb studi scan electron microscopi characterist factor adsorpt process ph time investig famotidin use modifi nanosorb equilibrium adsorpt studi famotidin aminophenol graft agezn analys adsorpt isotherm langmuir freundlich temkin model famotidin releas process investig simul biolog fluid intestin fluid ph gastric fluid ph demonstr famotidin releas period h ph min ph respect result reveal optim perform aminophenol graft agezn sustain drug deliveri | D058185;D053758 | T073;T130 |
34,694,720 | one pot synthesi chlorin e nano precipit colorect cancer treatment ce nps colorect cancer treatment drug nanoparticl free addit carrier hold great promis drug deliveri suitabl therapi cancer herein develop one pot method prepar chlorin e ce nano precipit ce nps effect photodynam therapi colorect cancer drug load ce nps around show accept stabil high biocompat well effect reactiv oxygen speci ros generat capabl result ce nps produc signific elev ros upon laser irradi achiev better anticanc benefit free ce | D015179;D053758;D010778;D011166 | T073;T061;T191;T123;T109 |
34,694,719 | biosynthesi characteris solid lipid nanoparticl investig toxic breast cancer cell line solid lipid nanoparticl slns compris non toxic surfac activ lipid agent combin appropri ratio drug essenti oil goal research investig effect sln synthesis use essenti oil foeniculum vulgar mcf breast cancer cell line slns prepar homogenis ultrasound techniqu characteris dynam light scatter dls zeta potenti assess transmiss electron microscopi tem dimethylthiazol yl diphenyl tetrazolium bromid assay mtt assay flow cytometri acridin orang assay employ assess biolog activ slns averag particl size nm net surfac charg mv tem show mean particl size nm synthesis slns uniform round morpholog mtt assay show prepar slns high toxic mcf cell low toxic normal huvec cell flow cytometri reveal noteworthi rise subg peak cell cycl cancer cell treat slns compar control indic apoptosi cancer cell result also show discolour slns treat cell confirm induct apoptosi toxic slns mcf cell | D001943;D053758;D004364 | T121;T191;T073 |
34,694,718 | treatment tumour tissu radio frequenc hyperthermia use antibodi carri nanoparticl intellig inorgan nanoparticl design produc use imag annihil tumour cell radio frequenc rf hyperthermia nanoparticl synthesis provid rf hyperthermia must magnetit properti purpos magnetit nanoparticl first synthesis coprecipit method nm superparamagnet nanoparticl cover gold ion without lose magnet properti step gold ion reduc around magnetit nanoparticl surfac modif gold coat magnet nanoparticl perform next step self assembl monolay creat use cysteamin aminoethanethiol molecul two differ end group sh nh molecul react gold surfac sh group nh group give posit charg nanoparticl monoclon antibodi monoclon anti n cam clone ncam ob immobilis ethyl dimethylaminopropyl carbodiimiden hydroxysuccinimid method antenna rf system mhz creat rf hyperthermia antibodi nanoparticl bind rate cytotox test follow vitro vivo experi main result antibodi bound gold coat magnet nanoparticl success connect tumour cell rf hyperthermia tumour size decreas owe apoptosi necrosi tumour cell | D006979;D058185;D009369 | T061;T191;T130 |
34,694,717 | nephroprotect role nanoencapsul tinospora cordifolia willd use polylact acid nanoparticl streptozotocin induc diabet nephropathi rat current field nanomedicin use activ compound medicin plant emerg therapi diabet nephropathi studi renoprotect effect tc load pla nanoparticl tc pla nps streptozotocin stz induc diabet nephropathi rat investig result show nephroprotect effect tc pla nps reduc blood glucos level regul renal paramet decreas cytokin level reduc mrna express level differ gene relat diabet nephropathi | D003920;D003928;D053758;D031610 | T002;T073;T047 |
34,694,716 | antibiofilm antimicrobi efficaci evalu polypyrrol nanotub embed amin gum acacia base nanocomposit sustain develop natur polysaccharid base hybrid composit high import effect replac metal nanoparticl divers applic polypyrrol nanotub ppynt embed surfac amin gum acacia aga produc ecofriend nanocomposit biomed applic morpholog ppynt enhanc aga ppynt aga hybrid nanocomposit studi scan electron microscopi transmiss electron microscopi affirm interact characteris x ray diffract raman fourier transform infrar uv visibl spectroscopi interest prepar ppynt aga nanocomposit exhibit biofilm inhibit gram negat pseudomona aeruginosa gram posit streptococcus pneumonia fungal strain candida albican promis antimicrobi perform studi establish good inhibit ppynt aga hybrid composit various microorgan stabil nanocomposit coupl antimicrobi activ enabl effect strategi diagnos control pathogen | D000890;D053768;D053761;D043942 | T121;T073 |
34,694,715 | antimicrobi potenti vitro cytotox studi polyvinyl pyrollidon stabilis silver nanoparticl synthesis lysinibacillus boronitoleran main emphasi herein eco friend synthesi assess antimicrobi potenti silver nanoparticl agnp cytotox studi silver nanoparticl synthesis extracellular method use bacteri supernat biosynthesis silver nanoparticl characteris uv vis spectroscopi transmiss electron microscopi tem fourier transform infrar spectroscopi dynam light scatter zeta potenti analysi synthesis silver nanoparticl exhibit characterist peak nm tem analysi depict spheric shape approxim nm size nanoparticl silver nanoparticl carri charg mv confirm stabil biogen polyvinyl pyrrolidon coat agnp exhibit signific antimicrobi effect opportunist pathogen gram posit gram negat bacteria fungi silver nanoparticl equal affect growth gram posit gram negat bacteria maximum inhibit zone observ mm minimum mm pseudomona aeruginosa fusarium graminearum respect minimum inhibitori concentr mic agnp p aeruginosa staphylococcus aureus record gml synthesis nanoparticl exhibit signific synergist effect combin convent antibiot cytotox estim use cc skelet muscl cell line via dimethylthiazol yl diphenyltetrazolium bromid mtt test lactat dehydrogenas assay direct relat concentr agnp length exposur basi mtt test ic agnp cc cell line approxim gml concentr h exposur | D000890;D053768 | T121;T073 |
34,694,714 | recent advanc urea biosensor biomed applic quick progress health care technolog recurr measur biochem factor blood compon lead advanc develop growth biosensor technolog necessari effectu patient concern review wok author present concis inform brief discuss develop made progress potentiometr field effect transistor graphen electrochem optic polymer nanoparticl nanocomposit base urea biosensor past two decad work author also centr differ proceduresmethod detect urea use amperometr potentiometr conductometr optic process graphen polym etc utilis immobilis materi fabric biosensor compar revis accomplish various procedur urea analysi use differ materi base biosensor disclos electrochem potentiometr biosensor promis one among term rapid respons time extens shelf life resourc design | D015374;D003217;D006108;D053761 | T073;T075;T059;T196;T109 |
34,694,713 | liposom nano formul cation polar lipid dotap cholesterol suitabl ph respons carrier molecular therapeut drug tran retino acid deliveri lung cancer cell molecular target drug atra demand suitabl carrier deliv cancer site due poor bioavail drug resist atra lipid carboxyl acid nano formul cation lipo atra dotap cholesterol atra ph respons releas intracellular drug accumul anticanc effect human lung cancer cell line analys analysi physicochem characterist develop lipo atra mol reveal size dnm zeta potenti encapsul effici atra releas lipo atra vitro signific p higher acid ph compar ph intracellular uptak atra lipo atra treat cell seven fold higher mgml three fold uptak observ free atra treatment mgml lipo atra treatment caus high signific p decreas percent cell viabil h compar free atra treatment overal result prove develop lipo atra suitabl physicochem properti enhanc atra releas acid ph maintain stabil physiolog ph temperatur result increas atra uptak lung cancer cell enhanc treatment effici henc conclud dotap lipo atra suitabl carrier atra deliveri solid cancer cell | D008081;D008175 | T191;T109 |
34,694,712 | statist approach synthesis biogen silica nanoparticl rice husk conjug justicia adhatoda extract green slow releas biocid biogen silica synthesis rice husk use control releas system eco friend biocid consist justicia adhatoda extract fourier transform infrar spectroscopi ftir indic presenc ester bond silica support conjug justicia adhatoda extract surfac area analysi microscopi confirm high level justicia adhatoda extract load silica support phytochem investig justicia adhatoda done gas chromatographi mass spectrometri gc ms spectroscopi moreov compar nake biogen silica nanoparticl better thermal stabil determin conjug system extract compound trial kinet releas silica justicia adhatoda load justicia adhatoda releas within h rate releas becam slow net releas justicia adhatoda observ within h justicia adhatoda compound releas silica also show improv mortal rate store product pest rice weevil sitophilus oryza | D004202;D027902;D053758 | T131;T002;T167;T073 |
34,694,711 | evalu column studi use cynodon dactylon plant mediat amino group silica layer magnet nanoadsorb remov noxious hexaval chromium metal ion magnet nanoparticl desir adsorb uniqu superparamagnet natur enhanc bind specif surfac materi interact uniqu featur attract research use wider applic herein studi focus amino induc silica layer magnet nanoparticl amalgam plant extract product cynodon dactylon order turn potent adsorb materi continu column set elimin noxious distribut cr vi ionsin effluent select plant mediat magnetit nanoadsorb use fix column studi optimis attribut inlet concentr adsorb bed depth flow rate thoma yoon nelson bed depth model show best experiment fit breakthrough adsorpt time report various inlet concentr mgl adsorb bed depth cm volumetr flow rate mlmin breakthrough point evalu optimis attribut inlet concentr mgl pack adsorb depth cm flow rate mlmin min maximum remov effici better insight adsorpt metal ion larg scale industri effluent provid | D014874;D018508 | T131;T052;T057 |
34,694,710 | biosynthesi reduc graphen oxid use turbinaria ornata cytotox effect mcf cell graphen base nanomateri gain import biomedicin larg surfac area solubl biocompat green synthesi econom method applic rapid sustain biofunction reduc graphen oxid trgo nanosheet synthes use methanol extract turbinaria ornata bioreduct graphen oxid primarili confirm character use uv visibl fourier transform infrar ftir x ray diffract spectroscopi character zeta potenti transmiss electron microscopi ftir spectra trgo show decreas band intens oxygen group thus confirm effect deoxygen zeta potenti valu mv reveal synthes trgo high stabl cytotox effect trgo mcf mcf cell ascertain use mtt assay show greater cytotox effect mcf cell ic trgo treatment mcf calcul g onefold lower cytotox effect methanol extract ornata gml addit statist signific differ cell viabil mcf mcf cell treatment trgo henc studi result effici green reduct produc rgo nanosheet possess cytotox breast cancer cell | D000970;D006108 | T121;T196;T109 |
34,694,709 | review three dimension graphen synthesi electron biotechnolog applic unknown riddl last decad carbon base nanostructur buckybal c carbon nanotub cnt graphen three dimension graphen identifi promis materi electron electrochem energi storag batteri supercapacitor optic sens applic sinc discoveri graphen scientist devis mass product techniqu explor graphen promis materi wide rang applic electron solar cell applic requir materi good electron conduct mobil finit bandgap graphen zero bandgap materi prevent mainstream applic hand graphen good electron conduct mobil bandgap electrochem properti review articl focus synthesi graphen structur properti relationship biotechnolog electron applic hidden properti yet explor fulli | D006108;D049329;D037742 | T104;T073;T196;T109 |
34,694,707 | compar studi chitosan nanoparticl synthesi methodolog applic aquacultur toxic studi chitosan nanoparticl csnps recent use various applic aquacultur especi drug carrier aim studi synthesis investig superl method csnp synthesi applic aquacultur aquacultur base toxicolog screen method two differ method analys first direct ionic gelat method involv low molecular weight chitosan microparticl intermedi method b dynam light scatter characteris reveal csnp particl size nm method b respect lc valu brine shrimp toxic found ppt h method b respect acut toxic studi litopenaeus vannamei render lc valu ppt h method b respect zebrafish toxic studi reveal mortal rate mgl concentr method b respect increas express intracellular reactiv oxygen speci method b find conclud compar reduc toxic csnps deriv ionic gelat method make appropri applic aquacultur | D048271;D053758 | T121;T073;T109 |
34,694,706 | metabolom profil zro nanoparticl mct e cell author previous studi show zirconium oxid nanoparticl zro nps induc toxic effect mct e cell howev toxicolog mechan still unclear liquid chromatographi mass spectrometrytim flight mass spectrometri use reveal metabolit profil toxicolog mechan mct e cell respons zro nps result demonstr mct e cell treat zro nps h present differ metabol characterist follow zro np treatment h upregul downregul metabolit posit ion mode well upregul downregul metabolit negat ion mode identifi follow zro np treatment h upregul downregul metabolit identifi posit ion mode wherea upregul downregul metabolit confirm negat ion mode among differenti metabolit recognis potenti metabolit contribut induc toxic effect zro nps mct e cell differenti metabolit lysophosphatidylcholin lysophosphatidylethanolamid indic exposur zro nps may profound impact human cellular function impair membran system result also provid new clue toxicolog mechan zro np dental materi | D053758;D015040 | T073;T196 |
34,694,705 | transmiss dynam suscept pattern sar cov domest farm wild anim sustain one health surveil conserv public health prevent futur epidem pandem exact origin sever acut respiratori syndrom coronavirus sar cov sourc introduct human establish yet though might origin anim therefor conduct studi understand putat reservoir transmiss dynam suscept pattern sar cov anim rhinolophus bat presum natur progenitor sar cov relat virus initi pangolin thought sourc spillov human might infect human anim speci virus spillov pathway human remain unknown human anim transmiss testifi pet farm zoo free rang wild anim infect anim transmit virus anim natur set like mink mink mink cat transmiss anim human transmiss persist pathway mink human transmiss continu illumin multipl companion captiv wild anim infect emerg alpha variant concern b lineag wherea asiat lion infect delta variant b date multipl anim speci cat ferret non human primat hamster bat show high suscept sar cov experiment condit swine poultri cattl show suscept found sar cov wild anim reservoir confront control virus human might carri risk welfar conserv wildlif well suggest vaccin pet captiv anim stop spillov spillback event recommend sustain one health surveil anim human environment interfac detect prevent futur epidem pandem diseas x | D000086382;D002418;D002685;D000074823;D013553 | T078;T015;T047;T067 |
34,694,703 | develop sustain rout product high fructos syrup polyfructan inulin author use mesopor silica microspher support immobil inulinas aspergillus brasiliensi mtcc process cross link optim oper condit ph particleenzym ratio glutaraldehyd concentr mm maximum immobil yield obtain cross link time h subsequ cross link inulinas util hydrolysi inulin maximum fructos concentr gl achiev optimum condit ph temperatur c h furthermor perform reusabl studi inulin hydrolysi observ immobil inulinas could reus subsequ cycl hydrolysi thus provid facil commerci attract process high fructos syrup product | D005632;D007444 | T121;T130;T109 |
34,694,701 | behaviour alter induc chronic exposur nm silicon dioxid nanoparticl silicon dioxid nanoparticl sio nps wide invest medicin industri agricultur consum product optic imag agent cosmet drug deliveri howev toxic nps human health ecosystem extens studi littl inform avail behaviour toxic current studi aim find behaviour alter might induc chronic exposur nm sio nps balbc mice subject inject sio nps mgkg bw subject neurobehaviour test elev plus maze test elev zero maze test multiradi maze test open field test hole board test light dark box test forc swim test tail suspens test morri water maze test maze test multipl maze test treat mice demonstr anxieti like effect depress tendenc behaviour despair stress explor locomotor activ reduct error induct refer work memori find may suggest silica nps anxiogen could aggrav depress affect memori learn overal activ exploratori behaviour moreov find may indic nanomateri nms may induc potenti oxid stress bodi lead neurobehaviour alter possibl chang vital organ includ central nervous system | D053758;D012822 | T197;T073 |
34,694,700 | green synthesi tio nanoparticl prepar phyllanthus niruri leaf extract dye adsorpt isotherm kinet studi herein green synthesi tio nanoparticl use phyllanthus niruri leaf extract accomplish sol gel method structur particl size synthesis tio nanoparticl characteris x ray diffract xrd analysi size found nm fourier transform infrar spectra determin exist carboxyl hydroxyl function group imag sem analysi recommend porous heterogen surfac methyl orang mo dye remov examin use differ paramet ph time dose temperatur dye concentr maximum dye elimin percentag achiev ph g optimum adsorb dose kinet analysi suggest pseudo second order kinet model fine defin adsorpt dynam langmuir adsorpt isotherm studi reveal endotherm monolay adsorpt methyl orang dye negat valu g posit valu h show spontan endotherm adsorpt method | D053758;D029803;D014874 | T131;T002;T073 |
34,694,699 | vitro degrad haemolysi cytotox studi mg cezno nanocomposit magnesium ideal candid biodegrad implant major concern uncontrol degrad applic biomateri vitro corros cytotox mg cezno magnesium nanocomposit studi determin suitabl biodegrad materi polycrystallin natur mg cezno assess use optic microscop hydrophob natur mg cezno determin contact angl measur corros resist magnesium nanocomposit test phosphat buffer solut pbs improv gradual deposit protect layer surfac h cytotox mg cezno evalu dimethylthiazol yl diphenyltetrazolium bromid mtt assay calcium deposit alizarin red stain use sarcoma osteogen sao cell haemocompat test mg cezno show haemolysi higher safe valu biomateri cell viabil reduc h comparison control group calcium deposit sarcoma osteogen cell show brick red colour deposit control group mg cezno h preliminari degrad result mg cezno show good corros resist howev improv need haemolysi cytotox studi use biodegrad materi orthopaed applic | D053761;D015034 | T197;T121;T073 |
34,694,698 | co sn cu oxidesgraphen nanocomposit green catalyst prepar dioxo octahydroxanthen apoptosi induc agent mcf human breast cancer cell work co sn cu oxidesgraphen nanocomposit nm size synthes solid state microwav irradi method present sever advantag oper simplic fast low cost safe energi effici suitabl product high puriti nanoparticl advantag method need use solvent fuel surfact co sn cu oxidesgraphen nanocomposit character fourier transform infrar spectroscopi x ray diffract field emiss scan electron microscopi transmiss electron microscopi vibrat sampl magnetomet energi dispers x ray spectroscopi uv vis spectroscopi synthes nanocomposit use novel high effici catalyst synthesi dioxo octahydroxanthen room temperatur catalyst recover reus six run without loss activ also obtain nanocomposit exhibit signific anticanc activ breast cancer cell could induc apoptosi cancer cell | D001943;D006108;D053761 | T073;T191;T196;T109 |
34,694,697 | ecotox synthesis copper nanoparticl soil bacteria releas metal nanoparticl soil pose serious threat ecosystem affect soil properti impos toxic soil microb involv biogeochem cycl work vitro ecotox synthesis copper nanoparticl cunp bacillus subtili mtcc pseudomona fluorescen mtcc common present soil investig three set colloid cunp ident physic properti synthesis chemic reduct method per batch yield gm toxic cunp soil bacteria investig mic minimum inhibitori concentr mbc minimum bactericid concentr cytoplasm leakag ros reactiv oxygen speci assay mic cunp rang gml gml b subtili p fluorescen respect mbc rang gml gml respect mic mbc test reveal gram negat p fluorescen sensit cunp compar gram posit b subtili main due differ cell wall structur composit cunp smaller hydrodynam size nm high toxic reveal mic mbc test cytoplasm leakag ros assay may due higher activ surfac area cunp greater membran penetr leakag cytoplasm compon generat extra cellular oxid stress reactiv oxygen speci ros caus cell death present studi realiz gaug negat impact inadvert releas nanoparticl environ howev situ experi know overal impact soil health soil microflora help find solut combat ecotox nanoparticl | D053768;D053758 | T073 |
34,694,696 | recoveri valuabl metal wast print circuit board use organ acid synthesis aspergillus niveus organ acid citric acid itacon acid oxal acid synthesis aspergillus niveus use bioleach metal wast print circuit board bioleach valuabl metal perform one step two step spent medium approach use niveus absenc wast print circuit board wpcbs dri cell weight niveus higher compar presenc wpcbs variat dri cell weight observ presenc differ particl size increas itacon acid oxal acid synthesi found reduc particl size mesh reach maximum titr itacon acid mm oxal acid mm day two step bioleach maximum recoveri zn ni cu wpcbs achiev day two step leach particl size mesh | D001230;D008670 | T197;T004 |
34,694,695 | multivari polynomi fit decay heat remov system pectin degrad fe sio nanobiocatalyst activ herein multivari lagrang interpol polynomi mlip multivari least squar mls method use deriv linear higher order polynomi two vari applic effect fabric pectin degrad fe sio nanobiocatalyst activ iumg three paramet name ph valu pectinas load temperatur independ variabl optim maxim anobiocatalyst activ depend variabl passiv system reliabl estim decay heat remov dhr nuclear power plant success criteria system depend three type temperatur exceed respect design safeti limit consid depend variabl signific paramet use independ variabl statist valid multivari polynomi done test hypothesi compar studi propos approach give signific result first applic optimum condit maximum activ use linear mlip method ph pl temp c maximum activ use second order mlip method method mls optim valu independ variabl ph pl temp c depict tabl dhr system signific result obtain depict tabl | D010368;D012822 | T197;T109;T121;T123 |
34,694,694 | flexibl deform collagen hydrogel tube reproduc immunolog tissu deform blood vessel pharmacokinet test model sinc biochem reaction blood vessel play essenti role immun respons various diseas vitro vascular model high demand medic field howev vascular model often tend difficult mimic biomed reaction faith lack implement tissu deform inflammatori mediat induc deform reaction blood vessel flexibl deform collagen hydrogel tube devic reproduc self stand collagen tube enabl tissu deform flexibl biochem reaction achiev contract tissu cell level contract tissu reliev stress cell reaction maintain cellular junction even tight junction broken also drug perfus test antihistamin chemic easili perform due connector part proper inhibit inflammatori reaction moreov traction forc endotheli cell analyz n two type scaffold differ stiff believ potenti flexibl tissu model reproduc biochem reaction contribut fabric vascular tissu model mimick vivo high similar platform biomed research pharmacokinet test | D020100;D023822 | T061;T122 |
34,694,693 | local hormon growth factor enhanc orthodont tooth movement systemat review anim studi prolong treatment time main reason capabl affect patient complianc orthodont treatment | D006728;D014087 | T121;T061;T125 |
34,694,692 | amino acid complex aacomplex benefit cosmet product vitro vivo clinic studi amino acid major compon skin natur moistur factor play role regul skin hydrat skin ph | D000596;D003358 | T167;T073;T121;T123;T116 |
34,694,687 | proteom profil arachi hypogaea respons drought stress overexpress ahlea improv drought toler drought main factor restrict peanut growth molecular mechan under peanut drought toler remain unclear herein seedl stage drought resist peanut cultivar j subject drought stress proteom profil systemat analys isobar tag relat absolut quantif itraq result complement previous transcriptom result total protein identifi proteom analysi reveal express level protein alter drought stress among differenti express protein dep upregul downregul enrich metabol pathway dep involv phenylpropanoid biosynthesi flavonoid biosynthesi plant hormon signal transduct proteom data previous transcriptom result reveal group genesprotein express trend includ lea late embryogenesi abund gene ahlea present studi show overexpress ahlea gene enhanc drought resist transgen arabidopsi plant activ relat antioxid enzym transgen plant signific chang ahlea gene found locat cytoplasm cell membran subcellular local experi work systemat analys differenti express protein peanut respons drought stress provid import candid function analysi stress respons peanut result also indic ahlea play import role peanut respons drought stress | D010367;D055864 | T070;T002 |
34,694,686 | recombin nanobodi muc tandem repeat inhibit growth invas metastasi vascular spontan mous mammari tumor alter glycosyl pattern muc mucin tandem repeat carcinoma shown negat affect adhes properti malign cell enhanc tumor invas metastasi addit muc overexpress close interrel angiogenesi make great target immunotherapi alongsid easier interact nanobodi singl domain antibodi antigen compar convent antibodi usual associ superior desir result herein evalu preclin efficaci recombin nanobodi muc tandem repeat suppress tumor growth angiogenesi invas metastasi express nanobodi demonstr specif toward muc overexpress cancer cell could intern cancer cell line ic valu concentr nanobodi exert half maxim inhibitori effect anti muc nanobodi muc posit human cancer cell line rang nm similar concentr could also effect induc apoptosi muc posit cancer cell normal cell muc negat human cancer cell immunohistochem stain spontan develop mous breast tumor prior vivo studi confirm cross reactiv nanobodi mous muc despit larg structur dissimilar mous human muc tandem repeat vivo dose g nanobodi per gram bodi weight tumor bear mice could attenu tumor progress suppress excess circul level il il il il il pro inflammatori cytokin also signific declin express ki mmp vegfr biomark well vasculogenesi evid immunohistochem stain tumor section anti muc nanobodi treat mice conclus anti muc tandem repeat nanobodi present studi could effect overcom tumor growth invas metastasi | D020080 | T114;T123 |
34,694,685 | cytosol local vitro assembl human de novo thymidyl synthesi complex de novo thymidyl synthesi crucial pathway normal cancer cell deoxythymidin monophosph dtmp synthes combin action three enzym serin hydroxymethyltransferas shmt dihydrofol reductas dhfr thymidyl synthas tym latter two target wide use chemotherapeut antifol fluorouracil protein transloc nucleus sumoyl suggest assembl compart thymidyl synthesi complex report intracellular dynam complex cancer cell situ proxim ligat assay show also detect cytoplasm result indic role thymidyl synthesi complex assembl may go beyond dtmp synthesi success assembl dtmp synthesi complex vitro employ tetramer shmt bifunct chimer enzym compris human thymidyl synthas dihydrofol reductas show shmt tetramer state requir effici complex assembl indic aggreg state evolutionarili select eukaryot optim protein protein interact last result regard activ complet thymidyl cycl vitro may provid use tool respect develop drug target entir complex instead individu compon | D013938;D013940 | T116;T114;T126;T123 |
34,694,684 | virus mimick cell membran coat nanoparticl cytosol deliveri mrna effect endosom escap cellular uptak repres major challeng field nanodeliveri major drug payload must local subcellular compart endosom order exert activ natur virus readili deliv genet materi cytosol host cell trigger membran fusion endocytosi influenza virus hemagglutinin ha protein found surfac fuse viral envelop surround membran endosom ph valu biomimet nanoparticl capabl endosom escap fabric use membran coat deriv cell engin express ha surfac evalu vitro virus mimick nanoparticl abl deliv mrna payload cytosol compart target cell result success express encod protein mrna load nanoparticl administ vivo protein express level signific increas local system deliveri scenario therefor conclud util genet engin approach express viral fusion protein surfac cell membran coat nanoparticl viabl strategi modul intracellular local encapsul cargo | D003600 | T026 |
34,694,683 | use blend wavelength order improv safeti efficaci laser hair remov pursuit safe effect devic laser hair remov continu use simultan multipl wavelength singl devic requir explor | D006204;D053685 | T061;T074 |
34,694,682 | kidney transplant recipi attitud toward covid vaccin barrier enabl vaccin accept identifi barrier enabl covid vaccin renal transplant recipi undecid vaccin | D000086382;D016030;D014612 | T129;T061;T121;T047;T116;T067 |
34,694,680 | transcriptom profil recess dystroph epidermolysi bullosa wound skin highlight drug repurpos opportun improv wound heal chronic wound present major diseas burden peopl recess dystroph epidermolysi bullosa rdeb inherit blister skin disord caus mutat cola encod type vii collagen major compon anchor fibril dermal epiderm junction treatment rdeb wound most symptomat consider unmet need tri improv acceler wound heal studi defin transcriptom profil gene pathway rdeb wound compar intact skin rdeb healthi control subject use revers transcriptom approach discov drug compound might restor rdeb wound profil toward intact skin differenti express analysi identifi differ rdeb wound intact skin rdeb wound display aberr cytokin cytokin interact toll like receptor signal jak stat signal pathway silico predict compound revers gene express signatur highlight methotrex lead candid overal studi provid insight molecular profil rdeb wound underscor possibl clinic valu revers transcriptom data analysi rdeb potenti approach discov repurpos drug diseas | D058492;D016108 | T061;T062;T047 |
34,694,679 | distribut evalu tacrolimus ascit fluid liver transplant recipi liver cirrhosi sensit ultra perform liquid chromatographi tandem mass spectrometri method tacrolimus narrow therapeut index larg individu differ pharmacokinet distribut tacrolimus ascit fluid influenc whole blood tacrolimus unclear studi sensit ultra perform liquid chromatographi tandem mass spectrometri method establish valid quantif tacrolimus ascit fluid liver transplant recipi chromatograph separ achiev agil zorbax eclips plus phenyl hexyl column mm mass spectrometri perform multipl reaction monitor condit transit mz tacrolimus concentr tacrolimus ascit fluid rang ngml account whole blood tacrolimus concentr linear mix model show statist signific posit correl steadi state trough blood concentr tacrolimus correspond amount tacrolimus excret ascit fluid consecut hour especi normal daili dose per unit bodi weight data suggest distribut tacrolimus ascit fluid great individu differ whole blood tacrolimus concentr dose per unit bodi weight confound factor may contribut excret tacrolimus ascit fluid influenc tacrolimus excret drain ascit fluid whole blood tacrolimus concentr neglig | D016031;D016559 | T061;T121;T109 |
34,694,678 | rice osclo caleosin protein negat regul cold toler jasmon signal pathway caleosin lipid droplet bind protein involv mainten lipid droplet structur signal transduct howev role caleosin protein stress resist limit report data rice caleosin protein gene osclo involv cold stress toler via influenc regul ja signal pathway overexpress line rnai line osclo subject cold stress recoveri measur electrolyt leakag surviv rate chang also detect genom wide transcriptom osclo overexpress plant osclo locat main lipid droplet express tissu test express upregul various stress condit subject cold treatment overexpress osclo decreas cold toler rnai line osclo higher surviv wt seedl osclo inhibit one jasmon biosynthet gene sever jasmon zim domain jaz gene upregul respons cold stress osclo constitut express caleosin protein regul plant cold resist inhibit jasmon signal ja synthesi | D012275 | T168;T002 |
34,694,676 | myth media oral collagen supplement skin nail hair review key compon hair skin nail strong consum interest dermatolog efficaci oral collagen supplement oral supplement collagen peptid increas popular recent year | D019587;D009262;D015595 | T023;T033;T061;T168;T042 |
34,694,674 | self serv bias therapist evalu client prematur treatment termin approxim replic murdock et al often cite studi murdock et al found therapist like attribut prematur treatment termin client characterist find author interpret term self serv bias ssb replic extend studi murdock et al studi psychologist psychotherapist n read two case vignett prematur treatment termin client subject set either describ client therapist client next particip use three attribut subscal blame therapist client situat evalu potenti caus prematur termin way test whether particip would manifest ssb also investig whether therapist score self confid need closur link ssb tendenc unlik murdock et al found overal ssb howev stronger need closur relat ssb tendenc ie less endors blame therapist attribut client condit r p r therapist client condit r p result suggest ssb ubiquit phenomenon therapist evalu prematur termin problem willing attend role depend extent need closur | D011369;D011613 | T054;T061 |
34,694,673 | polycaprolactonegelatin electrospun nanofibr contain biolog produc tellurium nanoparticl potenti wound dress scaffold physicochem mechan biolog characteris biolog synthesis tellurium nanoparticl te nps appli fabric te np embed polycaprolactonegelatin pclgel electrospun nanofibr antioxid vivo wound heal properti determin synthesis nanofibr characteris use scan electron microscopi sem energi dispers x ray edx spectroscopi element map thermogravimetr analysi tga fourier transform infrar ftir spectroscopi mechan properti surfac hydrophob scaffold investig use tensil analysi contact angl test respect biocompat produc scaffold mous embryon fibroblast cell evalu use mtt assay highest wound heal activ score achiev scaffold contain te nps wound treat pclgelt nps inflamm state equal posit control also mention scaffold repres posit effect collagen format collagen fibr horizontalis dose depend manner antioxid potenc te np contain scaffold demonstr lower level malondialdehyd mda catalas time higher level glutathion gsh time pclgelt np treat sampl negat control obtain result strong demonstr heal activ produc nanofibr infer scaffold contain te nps suitabl wound dress | D057139;D053758 | T073 |
34,694,672 | anti biofilm anti virul effect silica oxid nanoparticl conjug lectin purifi pseudomona aeruginosa pseudomona aeruginosa lectin purifi nanoparticl conjug attempt inhibit biofilm format thirteen p aeruginosa isol obtain chicken meat sampl biofilm produc lectin produc lectin purifi fold final specif activ umg four nanoparticl type prepar via laser ablat platinum pt gold au silica oxid sio tin oxid sno four type characteris puls feed use conjug lectin nanoparticl pt au sio sno nanoparticl inhibit biofilm format especi sio nanoparticl higher effect conjug purifi lectin sio conjug lectin signific p inhibit biofilm format effect control nanoparticl conjug lectin au pt nanoparticl sno conjug lectin inhibit biofilm signific compar control p rhlr gene express decreas presenc sio conjug lectin furthermor lectin pt au sio sno nanoparticl separ conjug lectin effect biofilm inhibitor sio conjug lectin signific anti biofilm moreov virul factor regulon rhlr reduc sio conjug lectin indic conjug may also decreas virul p aeruginosa | D053758;D011550 | T007;T073 |
34,694,671 | nephroprotect effect bryophyllum pinnatum mediat silver nanoparticl ethylen glycol induc urolithiasi rat larg popul suffer multifactori urolithiasi worldwid reoccurr rate almost male femal present studi nephroprotect effect silver nanoparticl agnp synthesis bryophyllum pinnatum evalu ethylen glycol induc urolithiasi rat b pinnatum mediat agnp found spheric polydispers particl averag size nm determin transmiss electron microscopi analysi show absorpt peak nm uv vis spectrophotometr analysi reveal role hydroxyl group synthesi fourier transform infrar spectroscopi analysi zeta potenti valu mv crystallin natur fcc structur demonstr base x ray diffract analysi anim studi perform male wistar rat divid six equal group demonstr signific increas serum total protein albumin globulin signific decreas ast alt creatinin bun calcium phosphorus group v vi compar group ii iv crystalluria observ rat given b pinnatum agnp histopatholog observ group v vi show mild degen chang restor mainten kidney parenchyma compar group ii iv rat thus author conclud benefici prevent therapeut nephroprotect effect b pinnatum mediat agnp ethylen glycol induc urolithiasi rat | D031962;D053768;D052878 | T002;T073;T047 |
34,694,670 | recent nanotheranost applic cancer therapi diagnosi review nanotheranost attract much attent due widespread applic molecular imag cancer therapi molecular imag use nanoparticl attract special attent diagnosi cancer earli stage progress made nanotheranost studi drug releas accumul target tissu biodistribut treatment effect import factor howev accord studi conduct regard nanoparticl advantag limit examin use clinic applic main goal review explor recent advanc nanotheranost cancer therapi diagnosi attempt present recent studi nanotheranost use contrast agent various imag modal platform cancer therapi | D053758;D009369 | T191;T073 |
34,694,669 | magnet core shell fe tio nanocomposit broad spectrum antibacteri applic author synthesis core shell fe tio nanocomposit consist fe magnet core tio extern shell tio shell primarili intend use biocompat antimicrobi carrier drug deliveri possibl applic wastewat remedi purpos known antibacteri photocatalyt properti magnet core enabl quick easi concentr separ nanoparticl magnetit nanoparticl synthes hydrotherm rout use ferric chlorid singl sourc precursor magnetit nanoparticl coat titanium dioxid use titanium butoxid precursor core shell fe tio nanostructur particl character xrd uv spectroscopi ft ir tem vsm techniqu satur magnet fe nanoparticl signific reduc emug tio coat antibacteri studi magnet nanoparticl titania coat magnet nanocomposit carri gramv gram bacteria staphylococcus aureus pseudomona aeruginosa shigella flexneri escherichia coli salmonella typhi use well diffus techniqu inhibit zone e coli mm h higher bacteri strain nevertheless uncoat tio coat magnetit nanocomposit show admir antibacteri activ bacteri strain | D004926;D053761 | T007;T073 |
34,694,668 | investig vitro phototherm effect green synthes apigenin coat gold nanoparticl colorect carcinoma appli toxic chemic synthesi stabl gold nanoparticl one limit gold nanoparticl therapeut applic phototherm therapi plant compound apigenin api therapeut potenti appli synthesi gold nanoparticl api coat gold nanoparticl api aunp averag size nm surfac charg mv synthes simpl effici techniqu stabil api aunp biolog environ verifi uv vis spectroscopi base raman ftir spectroscopi analysi chemic bind api surfac api aunp hydroxyl carbonyl function group found main reason stabil api aunp comparison citrat coat gold nanoparticl cit aunp synthes api aunp caus major toxic effect ppm api aunp mediat phototherm therapi lead indiscrimin erad almost half mous fibroblast l colorect cancer ct cell flow cytometri analysi reveal cell death mechan main apoptosi apoptosi trigger cell death phototherm treatment api aunp prefer common use gold nanoparticl phototherm treatment most trigger necrosi cell death pathway | D015179;D053768 | T191;T073 |
34,694,667 | temperatur regul gold nanoparticl sensor immun chromatograph rapid test kit reproduc sensit studi immun chromatograph kit use sinc sever year rapid detect infecti diseas also call later flow techniqu use antigen antibodi detect seri step involv develop immun chromatograph test kit still prepar gold nanoparticl aunp import qualiti variabl immun chromatograph test kit sensit immun chromatograph test must specif detect specif antigen antibodi impli test kit show fals result second test kit sensit enough give readabl result intens test line increas decreas concentr analyt sampl various factor influenc perform test temperatur differ aunp prepar alter assay kinet contribut assay variabl factor assay compon manufactur process reagent variat also contribut assay precis accuraci import note assay reproduc combin effect individu sourc variabl author synthes aunp immedi control reaction temperatur differ batch malaria rapid test kit develop test kit sensit analys found test kit design temperatur control aunp sensor reproduc uniform term batch batch sensit aunp synthes convent turkevich fern process | D008288;D053768 | T073;T047 |
34,694,666 | enhanc vitro antitumour activ epirubicin breast cancer cell use immunoliposom formul epirubicin epi one potent breast cancer bc chemotherapeut agent advers effect limit efficaci herein epi select load liposom carrier target monoclon antibodi herceptin prepar process liposom modifi ethanol inject method follow herceptin conjug vitro cell toxic cellular uptak optimum formul cancer cell line evalu result show drug load dl encapsul effici ee liposom prepar method yield respect averag size nake liposom epi lipo immunoliposom epi lipo mab nm relat monodispers distribut confirm sem micrograph releas kinet follow higuchi model nake immunoliposom vitro cytotox studi three differ bc cell line includ bt mda mb mcf demonstr higher toxic epi herceptin conjug form epi lipo mab comparison free epi epi lipo overexpress cell line addit cellular uptak studi show higher uptak immunoliposom mcf cell comparison nake liposom conclus data show target deliveri epi breast cancer cell achiev epi lipo mab vitro strategi could use breast cancer therapi studi | D001943;D008081 | T191;T109 |
34,694,665 | mesopor silica nanoparticl prepar differ method biomed applic compar studi current investig mesopor silica nanoparticl obtain various techniqu name sol gel micro emuls hydrotherm synthesi effect method final featur obtain mesopor silica nanoparticl studi obtain nanoparticl investig tem bet surfac area zetas xrd ftir prepar method effect evalu drug releas behaviour use doxycyclin hyclat model drug addit degre compat sao cell line also determin morpholog microstructur silica nanoparticl found depend utilis method techniqu produc particl particl size nm also surfac area g respect howev differ prepar method show remark chang physic chemic integr drug releas test show faster releas compar make applic case requir larg dose short period howev releas behaviour satisfi treatment requir long period relat highest releas rate prepar method influenc cell viabil show accept cell cytotox compar | D053758;D012822 | T197;T073 |
34,694,664 | optimis food grade mix surfact base l ascorb acid nanoemuls use respons surfac methodolog co surfact free l ascorb acid laa nanoemuls prepar use mix surfact soya lecithin tween respons surfac methodolog rsm use optimis emulsifi condit laa nanoemuls effect water proport ww homogenis pressur mpa surfact concentr ww laa concentr ww respons size droplet nanoemuls stabil investig rsm result show valu respons success predict second order polynomi model coeffici determin droplet size nanoemuls stabil respect optimum prepar condit l laa nanoemuls water proport mpa homogenis pressur surfact concentr laa concentr end one month storag studi retent laa optimis nanoemuls store c c respect result may provid valuabl contribut food pharmaceut industri develop deliveri system food addit nutraceut compon | D001205;D013501 | T122;T121;T127;T120;T109 |
34,694,662 | nuclear factor erythroid relat factor human papillomavirus relat cancer high risk human papillomavirus hr hpv infect necessari caus develop cervic cancer moreov hr hpv also associ cancer anus vagina vulva peni oropharynx hr hpvs target modifi function differ cell biomolecul glucos amino acid lipid transcript factor tf p nuclear factor erythroid relat factor nrf among other latter master tf maintain redox homeostasi nrf also induc transcript gene associ cell detoxif sinc process critic cell physiolog nrf deregul associ cancer develop nrf crucial molecul hpv relat cancer develop underexplor moreov nrf activ also associ resist chemotherapi radiotherapi cancer review focuss import nrf hpv relat cancer develop resist therapi potenti therapi associ nrf molecular target | D052685;D051267;D009369;D030361 | T005;T191;T047;T123;T116 |
34,694,661 | evolut innat defens human skin often compar barrier system gastrointestin urogenit respiratori line human skin million year subject fundament chang structur function life land start first chang consist format coher imperm stratum corneum two leg locomot follow loss bodi hair format sweat gland major chang took place agricultur revolut investig settlement domest anim plant live togeth give nomad life hairless skin becam battlefield pathogen member skin microbiom arthropod visit human skin becam except show boost high develop immun system much complex compar skin speci recent found skin disinfect system cation intrins disord antimicrobi peptid cidamp date back origin life still activ present day integu skin restrict effect principl keratinocyt myeloid synergi kms recogn consequ high develop immun defens basic contribut kms cell keratinocyt neutrophil macrophag regul innat immun emphas antimicrobi peptid chemokin becam major keratinocyt product format imperm str corneum membran enabl kms cell accumul within upper skin level caus special group human skin diseas pustular dermatos | D015603;D012867 | T025;T022 |
34,694,658 | tool use behavior three wild bonobo communiti kokolopori compar studi tool technolog extant primat especi closest live relat offer window evolutionari foundat tool use hominin wherea chimpanze tool technolog well studi across popul scarciti describ tool technolog wild popul closest live relat bonobo mysteri provid first report tool use repertoir kokolopori bonobo describ detail use leaf umbrella rainfal aim improv knowledg bonobo tool use capac wild tool use repertoir kokolopori bonobo similar nearbi popul wamba compris eight behavior none forag context month period document instanc leaf umbrella use individu three communiti suggest behavior habitu leaf umbrella tool user adult femal observ nonadult use leaf umbrella singl occas studi theori tool technolog often base use tool forag task tool use bonobo typic occur nonforag context across popul therefor incorpor forag nonforag context theoret framework essenti wish advanc understand evolutionari trajectori tool technolog human | D019974;D053001 | T053;T015 |
34,694,655 | outcom extracorpor membran oxygen support covid non covid patient veno venous extracorpor membran oxygen v v ecmo support increas use manag covid relat acut respiratori distress syndrom ard howev clinic decis make initi v v ecmo sever covid still remain unclear order determin optim time patient select investig outcom covid non covid patient undergo v v ecmo support | D000086382;D015199;D012128 | T061;T047;T067 |
34,694,653 | hint relat neuropathi greek patient charcot mari tooth diseas autosom recess axon neuropathi neuromyotonia aran nm rare hereditari neuropathi within charcot mari tooth diseas cmt spectrum link mutat histidin triad nucleotid bind protein hint gene hint relat neuropathi particular common select popul central eastern europ rare western european cohort investig date greek popul present investig frequenc hint neuropathi select cohort greek index patient autosom recess sporad axon hereditari neuropathi accord standard molecular genet procedur identifi patient biallel mutat hint compris case case also display neuromyotonia cg c pargpro hint mutat present case homozyg ct c pcysarg case compound heterozyg hint relat neuropathi patient character earli onset neuromyotonia two patient noteworthi clinic featur one case develop myoclon epilepsi display adduct thumb conclud hint relat neuropathi common select greek patient hereditari neuropathi within cmt spectrum accord european popul | D002607;D020386 | T047 |
34,694,652 | impact covid therapeut plasma exchang servic within south east asian region consensus recommend global perspect therapeut plasma exchang tpe neuroimmunolog disord play increas import role within southeast asian sea region south east asian therapeut plasma exchang consortium seatpec form promot educ research tpe within region advent covid pandem produc challeng develop expans servic | D000086382;D010951 | T061;T047;T067 |
34,694,651 | lack neuropeptid ff signal mice lead reduc repetit behavior alter drink behavior fuel type select although best known involv modul nocicept neuropeptid ff npff group peptid suggest fulfil varieti biolog function feed anxieti behavior thermogenesi howev evid support function npff most pharmacolog leav physiolog relev unaddress examin physiolog impact lack npff signal gender use npff mous model npff express mous restrict spinal cord brainstem cognat receptor npffr wider distribut throughout brain male femal npff mice show reduc repetit behavior evidenc marbl buri test self groom test decreas anxieti relat behavior npff mice also observ open field test lesser degre elev plus maze test moreov male femal npff mice exhibit increas water intak result increas drink size rather number drink event fast refeed challeng npff mice gender display alter reparatori exchang ratio reflect greater fuel type flexibl npff mice otherwis wild type like regard bodi weight bodi composit feed behavior locomot energi expenditur togeth find reveal import physiolog role npff signal regul anxieti relat repetit behavior fluid homeostasi oxid fuel select highlight therapeut potenti npff system number behavior metabol disord | D004327 | T055 |
34,694,650 | case seri vaccin induc thrombot thrombocytopenia london teach hospit chadox ncov vaccin associ increas risk thrombosi understand manag rare event evolv current recommend treatment includ human normal immunoglobulin nonheparin anticoagul direct oral anticoagul report describ three consecut patient present london teach hospit vaccin induc thrombot thrombocytopenia vitt also refer vaccin induc prothrombot immun thrombocytopenia patient rang age year two known previous medic comorbid two patient cerebr venous sinus thrombosi one deep vein thrombosi two treat anticoagul one oral rivaroxaban intraven argotraban infus later convert oral apixaban one patient receiv three dose human normal immunoglobulin day therapeut plasma exchang case seri may use improv understand clinic cours manag vitt | D000086382;D013921;D013927;D014612 | T046;T129;T121;T047;T116;T067 |
34,694,648 | investig mir p load adipos stem cell deriv exosom wound heal full thick skin defect investig function mir p load adipos stem cell adsc deriv exosom adsc exo wound heal full thick skin defect | D055354;D035683 | T026;T114;T123 |
34,694,647 | long term outcom holmium laser enucl prostat predict model symptom recurr holmium laser enucl prostat holep repres one studi surgic techniqu benign prostat hyperplasia bph efficaci symptom relief wide depict howev evid avail regard possibl predictor symptom recurr aim evalu long term outcom symptom recurr rate predictor patient underw holep | D053685;D000069451;D059411;D011183;D011467;D011470 | T046;T023;T061;T191;T047;T184;T074 |
34,694,646 | asymmetr express matern mrna govern first cell fate decis goal preimplant develop establish fate embryon extra embryon cell howev cell fate determin earli mammalian embryon develop remain unclear report high mobil group hmg protein famili member hmga distribut differenti mous two cell blastomer knockdown hmga express one two cell reduc number cell contribut inner cell mass icm suggest differenti distribut hmga blastomer two cell mous embryo affect select embryon cell lineag mechanist hmga promot express icm specif gene sox result studi show mous embryo demonstr heterogen earli two cell stage differ relat cell fate differenti earli mous embryo | D047108;D009865 | T038;T042;T039;T025 |
34,694,643 | tendoscop peritendon shave midport achill tendinopathi random placebo control studi achill tendinopathi among frequent tendon injuri sport despit evid base manag signific proport patient continu experi symptom first random trial investig effect tendoscop treatment midport achill tendinopathi compar placebo baselin month patient midport achill tendinopathi non respons month nonsurg treatment random assign receiv either tendoscop peritendon shave placebo tendoscop treatment primari outcom measur total score victorian institut sport assess achill visa questionnair due three advers event sural nerv injuri group receiv tendoscop treatment trial stop short plan particip patient includ complet month follow month complet month follow group estim favor endoscop treatment rang point confid interv ci month point month point ci month month tendoscop group improv point ci versus point ci placebo oper group despit smaller sampl size due advers event visa indic faster recoveri tendoscop treatment compar placebo data suggest tendoscop treatment midport achill tendinopathi test research howev techniqu need refin avoid sural nerv injuri | D000125;D013177;D052256 | T056;T023;T047 |
34,694,642 | caffein drink fruit juic epilepsi systemat review aim systemat review provid requir inform regard differ aspect relationship epilepsyantiseizur medic non alcohol drink recommend prefer report item systemat review meta analys prisma statement follow medlin scopus incept august systemat search key word use epilepsi seizur antiepilept antiseizur anticonvuls coffe tea soda juic drink cola diet key word combin primari search yield public pubm n scopus n studi met inclus criteria includ current systemat review total articl investig various non alcohol drink human studi studi case reportsseri articl animalin vitro studi none studi provid class evid limit evid suggest certain drink eg caffein energi drink might trigger seizur patient epilepsi avoid excess consumpt certain fruit juic eg grapefruit lime pomegran kinnow star fruit caffein drink howev daili coffe tea intak part healthi balanc diet consumpt need stop patient epilepsi coffeetea consumpt harm consum level mg caffein one sit cup coffe mg daili five cup coffe | D004827;D000067030 | T168;T033;T047 |
34,694,639 | insidi risk periprosthet fractur clinic function total hip arthroplasti biomechan studi will joint femor bone qualiti major risk factor periprosthet fractur total hip arthroplasti tha mortal similar nativ hip fractur higher short term morbid goal studi quantifi cortic strain site expect vancouv type b periprosthet fractur function bone miner densiti femor stem materi fixat method use seri autopsi retriev clinic asymptomat hip joint tha periprosthet bone miner content densiti assess use dual energi x ray absorptiometri gruen zone specimen underw combin cyclic axial torsion load increas increment n nm peak n nm specimen experienc signific higher strain later surfac anterior surfac indic bend load frontal plane rather axialtorsion load predomin effect multipl signific relationship p p found predict periprosthet strain calcul radiograph measur observ princip strain though tha present studi success clinic servic produc result indic femur rigid cement noncement implant potenti high risk vancouv type b fractur may predict radiograph | D019644;D005264;D006622;D057068 | T037;T047;T061;T074 |
34,694,637 | solubl klotho integrin erk pathway amelior myocardi fibrosi diabet cardiomyopathi solubl klotho skl close relat insulin resist major factor progress diabet cardiomyopathi dcm purpos studi investig role skl regul dcm mechan involv mous model type diabet induc high fat diet streptozotocin inject insulin resist cardiac fibroblast model establish high glucos high insulin kl gene overexpress achiev vivo vitro transfect adenovirus harbor kl cdna gene overexpress use evalu role skl pathophysiolog characterist dcm insulin resist cardiac fibroblast reduc skl express collagen deposit diabet mice construct streptozotocin exhibit sever insulin resist inflamm fibrosi left ventricular dysfunct skl downregul overexpress skl mitig insulin resist metabol disturb inflamm fibrosi upregul collagen iiii content ratio diabet state signific reduc find accompani notabl moder cardiac function blunt phosphoryl akt restor skl gene overexpress activ phosphoryl extracellular signal regul kinas dcm reduc result suggest skl protein overexpress exert defens measur amelior select insulin resist mous dcm thus reveal under mechan potenti human dcm treatment | D009206 | T024 |
34,694,633 | assort mate epistat mate trait architectur induc complex movement crow hybrid zone hybrid zone provid window evolutionari process govern speci diverg yet contribut mate choic tempor spatial stabil hybrid zone remain poor explor investig effect assort mate hybrid zone dynam mean mathemat model parameter phenotyp genotyp data hybrid zone black carrion gray coat hood crow best fit model narrow cline two mate trait loci maintain moder degre assort mate induc pre postzygot isol via posit frequenc depend select epistasi two loci induc hybrid zone movement favor allel convey dark plumag follow shift opposit direct favor gray coat phenotyp generat secondari contact unlink neutral loci diffus near unimped across zone result general robust choic match rule self referenc parent imprint effect genet drift overal studi illustr condit assort mate maintain steep cline mate trait loci without general genom wide reproduct isol emphas import genet mate trait architectur spatio tempor hybrid zone dynam | D046368 | T012 |
34,694,631 | use machin learn model nontradit spatial depend occup data spatial model occup data use estim map true presenc speci may depend biotic abiot factor well spatial autocorrel tradit research account spatial autocorrel occup data use correl normal distribut site level random effect might incap model nontradit spatial depend discontinu abrupt transit machin learn approach potenti model nontradit spatial depend approach account observ error fals absenc combin flexibl bayesian hierarch model machin learn approach present general framework model occup data account tradit nontradit spatial depend well fals absenc demonstr framework use six synthet occup data set two real data set result demonstr model tradit nontradit spatial depend occup data enabl broader class spatial occup model use improv predict accuraci model adequaci | D000069550 | T066 |
34,694,630 | myelin associ oligodendrocyt basic protein rs polymorph risk factor parkinson diseas rs polymorph myelin associ oligodendrocyt basic protein mobp gene locus associ amyotroph later sclerosi al al parkinson diseas pd two common neurodegen disord share featur regard etiolog pathophysiolog genet background mobp rs polymorph associ al littl known role pd | D010300 | T047 |
34,694,629 | distribut independ compon analysi divers neuroimag modal recent advanc neuroimag technolog provid opportun acquir brain imag differ modal studi human brain organ function structur perspect analysi imag deriv various modal involv common goal dimens reduct denois featur extract howev sinc modal vast differ data characterist current analysi usual perform use distinct analyt tool suitabl specif imag modal paper present distribut independ compon analysi dica repres new approach perform decomposit distribut level provid unifi framework extract featur across imag modal differ scale represent appli dica fmri imag success recov well establish brain function network neurosci literatur provid empir valid dica deliv neurolog relev find import discov sever structur network compon appli dica dti imag fiber track find dica deriv structur compon correspond sever major white fiber bundl best knowledg first time fiber bundl success identifi via blind sourc separ singl subject dti imag also evalu perform dica compar exist ica method extens simul studi | D008279;D059906 | T170;T059;T060 |
34,694,628 | climat chang women health role obstetrician gynecologist leadership climat chang one major global health threat world popul brought global warm due larg part increas level greenhous gase result human activ includ burn fossil fuel carbon dioxid anim husbandri methan manur industri emiss ozon nitrogen oxid sulfur dioxid vehiclefactori exhaust chlorofluorocarbon aerosol trap extra heat earth atmospher result extrem weather give rise wildfir air pollut chang ecolog flood turn result displac popul famili disrupt violenc major impact water qualiti avail food secur public health econom infrastructur limit abil civil societi maintain citizen safeti climat chang also direct impact human health well particular vulner popul affect includ women pregnant women children disabl elder compris major poor global addit effect climat chang disproport affect disadvantag communiti includ low incom communiti color lower incom countri highest risk advers impact disast occur due inequit distribut resourc socioeconom status climat crisi tilt risk balanc unfavor women sexual reproduct health right well newborn child health obstetriciangynecologist uniqu opportun rais awar educ advoc mitig strategi revers climat chang affect patient famili articl put climat chang context women reproduct health public health issu social justic issu human right issu econom issu polit issu gender issu need attent health well futur generat figo join broad coalit intern research medic communiti state current climat crisi present immin health risk pregnant peopl develop fetus reproduct health recogn need societi wide solut govern polici global cooper address reduc contributor includ fossil fuel product climat chang | D000397;D057231 | T070;T080;T069 |
34,694,625 | singl cell resolut plasma cell fate program health diseas long consid homogen popul dedic antibodi secret plasma cell phenotyp function heterogen increas recogn plasma cell first segreg base matur level complex subset might well underestim simpl dichotomi inde last decad new function attribut plasma cell includ limit cytokin secret howev proper character plasma cell heterogen remain elus part due technic issu cellular featur specif cell type cell intrins cell extrins signal could origin heterogen recent advanc technolog singl cell rna seq atac seq chip seq low cell number help elucid fate decis cell lineag similar approach could implement evalu heterogen fate activ b cell health diseas summar publish work shed light stimuli genet program shape b cell termin differenti singl cell level mice men also discuss fate heterogen plasma cell immun respons vaccin frame human plasma cell disord | D002454;D000081204;D007154;D000081246;D059010 | T047;T063;T059;T043 |
34,694,624 | direct bias habitat shift biogeograph inform cytonuclear discord hawaiian silversword allianc composita expand phylogenet analys hawaiian silversword allianc argyroxiphium dubautia wilkesia composita undertaken assess evolutionari biogeograph inform cytonuclear discord bias evolutionari direct ecolog transit within promin exampl adapt radiat | D019659 | T002 |
34,694,622 | transcriptom wide identif methyl site riboxi seq abil detect methyl site nm high throughput fashion import increas evid point divers landscap rna modif well possibl yet unidentifi function describ optim version riboxi seq built upon origin publish method accur profil ribosom rna rrna nm site minim rna input also robust enough identifi mrna intron exon site | D059467 | T086;T081 |
34,694,621 | target specif profil rna c methyl level use amplicon sequenc map posit quantifi level methylcytosin c modif differ type cellular rna import object field epitranscriptom bisulfit convers long gold standard detect c dna also appli rna detail method bisulfit treatment rna locus specif pcr amplif detect candid site sequenc illumina miseq platform | D017422 | T063 |
34,694,620 | detect vitro dart seq recent studi uncov cellular mrnas contain divers epitranscriptom compris chemic modifi base play import role gene express regul among high preval modif contribut sever aspect rna regul cellular function tradit method profil use antibodi immunoprecipit methyl rnas although power method requir high amount input materi recent develop dart seq antibodi free method profil low input rna sampl dart seq reli deamin cytidin invari follow site perform use simpl vitro assay ng total rna describ vitro dart method present detail protocol high sensit profil rna sampl interest | D017423 | T063;T059 |
34,694,619 | rna immunoprecipit follow high throughput sequenc map n methyladenosin n methyladenosin abund intern modif messeng rnas mrnas long noncod rnas lncrnas eukaryot influenc gene express regul rna process nuclear export mrna decay translat henc control fundament cellular process dysregul deposit acknowledg play role broad rang human diseas includ cancer rna immunoprecipit follow high throughput sequenc merip seq seq power techniqu map transcriptom wide level immunoprecipit fragment polyadenyl poli rich rna use specif anti antibodi immunoprecipit rna fragment togeth input control subject massiv parallel sequenc generat comprehens methyl profil signal enrich relat input control necessari order better comprehend pathogenesi behind aberr deposit | D059014 | T063;T059 |
34,694,618 | high throughput quantit yeast uorf regulatori impact use fac uorf eukaryot upstream open read frame uorf short translat region found mani transcript leader barbosa et al plos genet e zhang et al trend biochem sci modern transcript annot ribosom profil studi found thousand aug initi uorf mani uorf initi near cognat codon cug gug uug etc translat general decreas express main encod protein prevent ribosom reach main orf gene induc nonsens mediat decay nmd prematur termin mani cellular stress uorf contain transcript de repress due decreas translat initi young et al j biol chem tradit experiment evalu uorf involv compar express match uorf contain start codon mutat transcript leader report plasmid tedious process preclud analysi larg number uorf recent use fac uorf simultan assay thousand yeast uorf order evalu impact codon usag function lin et al nucleic acid res provid step step protocol assay | D012441 | T004 |
34,694,617 | transcriptom wide profil rna stabil gene express control multipl level includ rna transcript turnov determin relat contribut rna biogenesi decay steadi state abund cellular transcript remain challeng convent transcriptom approach provid tempor resolut deriv kinet paramet under steadi state gene expressionher describ protocol combin metabol rna label thiouridin chemic nucleosid convers whole transcriptom sequenc follow bioinformat analysi determin rna stabil cultur cell genom scale time resolv transcriptom thiol sh link alkyl metabol sequenc rna slamseq provid accur inform transcript half live across annot featur genom includ product transcript intron provid step step instruct time resolv transcriptom enhanc tradit rna sequenc protocol acquir tempor resolut requir direct measur cellular kinet rna turnov physiolog condit | D020871;D059467 | T081;T080;T044;T086;T045 |
34,694,616 | vivo rna structur probe dms mapseq rna extraordinari capac fold form intrins secondari structur play central role maintain function crucial way studi rna structur identifi function biolog environ last decad number differ chemic probe method use studi rna secondari structur present dimethyl sulfat base dms chemic probe method coupl next generat sequenc dms mapseq studi rna secondari structur vivodm modifi unpair adenin cytosin base convert mutationsmismatch use thermost group ii intron revers transcriptas tgirt analyz use sequenc valid techniqu model system rang drosophila human cell line thus increas techniqu broad rang applic dms mapseq provid high qualiti data use gene target well genom wide analysi | D059014;D009690 | T063;T059;T082;T028 |
34,694,615 | genom wide identif polyadenyl dynam ted seq polyadenyl deadenyl mrna major rna modif associ nucleus cytoplasm transloc mrna stabil translat effici mrna decay pathway current knowledg polyadenyl deadenyl expand due recent advanc transcriptom wide poli tail length assay wherea method measur poli length quantifi adenin base stretch end mrna develop cost effici techniqu reli base count call tail end displac sequenc ted seq sequenc high size select rna fragment includ poli tail piec ted seq provid accur measur transcriptom wide poli tail length high resolut econom suitabl larger scale analysi various biolog transit context | D026723 | T044 |