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safeti glycem outcom minim advanc hybrid close loop system pivot trial adolesc adult type diabet introduct trial assess safeti effect advanc hybrid close loop ahcl system autom basal auto basal autom bolus correct auto correct adolesc adult type diabet td materi method multicent singl arm studi involv intent treat popul individu adolesc age year adult age year td studi particip use minim ahcl system baselin run period sensor augment pump predict low glucos manag auto basal enabl day thereaft auto basal auto correct enabl studi phase day glucos target set mgdl day follow target day studi endpoint includ safeti event chang mean ac time rang tir mgdl time rang tbr mgdl run studi phase valu compar use wilcoxon sign rank test pair test result overal group time spent close loop averag involv exit per week compar run ahcl reduc ac wilcoxon sign rank test n tir increas wilcoxon sign rank test tbr reduc wilcoxon sign rank test similar benefit glycemia observ age group pronounc nighttim mgdl target increas tir n optim lower activ insulin time ait set ie h without increas tbr sever hypoglycem diabet ketoacidosi event studi phase conclus find show minim ahcl system safe allow achiev recommend glycem target adolesc adult td adjust target ait set may optim glycemia improv user experi clinic trial registr number nct

D003922

T047

treatment under form bayesian meta analysi effect treatment person relat variabl treatment respons purpos meta analysi synthes publish studi use treatment under form tuf sentenc level deficit peopl aphasia pwa studi aim examin group level evid tuf efficaci character effect treatment relat variabl sentenc structur famili complex treatment dose relat complex account treatment efficaci cate hypothesi examin effect person level variabl aphasia sever sentenc comprehens impair time postonset aphasia tuf respons method data singl subject multipl baselin tuf studi includ pwa analyz bayesian general linear mix effect interrupt time seri model use assess effect treatment relat variabl probe accuraci baselin treatment moder influenc person level variabl tuf respons also investig result result provid group level evid tuf efficaci demonstr increas probe accuraci treatment compar baselin phase greater amount tuf associ larger increas accuraci greater gain treat untreat sentenc find reveal general effect sentenc famili less complex treat sentenc aphasia sever may moder tuf respons peopl milder aphasia demonstr greater gain compar peopl sever aphasia sentenc comprehens perform moder tuf respons greater time postonset aphasia associ smaller improv treat sentenc untreat sentenc conclus result provid generaliz group level evid tuf efficaci treatment general respons consist cate hypothesi model result also identifi person level moder tuf aphasia sever time postonset aphasia preliminari estim effect vari amount tuf treat untreat sentenc taken togeth find add tuf evid may guid futur tuf treatment candid select supplement materi https doiorgasha

D001037

T048;T047

chang time covid sever mortal patient undergo cancer treatment unit state initi report asco registri peopl cancer increas risk sever acut respiratori syndrom coronavirus sar cov infect asco covid registri promot systemat data collect across us oncolog practic

D000086382;D009369

T191;T047;T067

ridc member yjgfyercuk rid protein famili novel endoribonucleas regul express specialist rna polymeras involv differenti nonomuraea gerenzanensi yjgfyercuk rid protein famili breadth conserv domain life includ wide distribut archetyp rida yjgf subfamili seven subfamili rid rid among subfamili rida famili biochem well character involv deamin reactiv enamineimin intermedi studi character protein rid subfamili name ridc nonomuraea gerenzanensi actinomycet character presenc two type rna polymeras due coexist genom two rna polymeras rnap chain encod gene rpob wild type rpob gene rpob r specialist mutant type rpob gene control antibiot product wide rang metabol adapt behavior found express rpob r regul posttranscript rna process untransl region utr rpob r mrna endoribonucleas activ ridc respons mrna process therebi overse sever tract morpholog biochem differenti also provid evid ridc may associ rnase p rna although rna requir rpob r mrna process vitro ridc endoribonucleas activ inhibit suggest exist negat feedback loop product role endogen synthesi modul biochem differenti microorgan import yjgfyercuk famili includ mani protein divers function involv detoxif rna matur control mrna translat found ridc endoribonucleas involv process rpob r mrna code special rna polymeras beta subunit overse morpholog differenti antibiot product nonomuraea gerenzanensi ridc mediat process promot rpob r mrna translat antibiot product ridc endoribonucleas activ inhibit suggest role endogen synthesi modul biochem differenti microorgan final show recombin ridc copurifi rna rna subunit rnase p escherichia coli extract suggest function interact ridc rna activ

D015964

T045

speech languag pathologist practic pattern design home practic program person aphasia survey purpos aim describ current practic speech languag pathologist regard creation implement home practic program person poststrok aphasia method survey particip american speech languag hear associ certifi speech languag pathologist caseload includ person aphasia recent creat least two home program person aphasia respond complet web base survey home program creation train technolog method track adher close open end question result analyz complet survey particip n creat home program greater caseload common intervent home program address function practic spoken express particip describ instruct techniqu includ build skill practic daili routin guid practic applic technolog formal mechan monitor adher less frequent report various factor identifi facilit barrier home program creation environment support other client factor ie motiv impair evid conclus studi provid insight speech languag pathologist home program creation implement result use consid mechan improv use adher home program support recoveri supplement materi https doiorgasha

D001037;D013066

T048;T047;T091

languag sampl analysi clinic practic speech languag pathologist barrier facilit need speech languag pathologist slps work children development languag disord dld perform languag sampl analysi lsa regular basi although regard lsa high inform goal set evalu grammat therapi primari aim studi identifi facilit barrier need relat perform lsa dutch slps work children dld secondari aim investig whether train would chang actual perform lsa

D013060;D013066

T040;T054;T091

autom extract tumor stage diagnosi inform surgic patholog report typic store unstructur note surgic patholog report contain data element valuabl cancer research requir labor intens manual extract although studi describ natur languag process nlp surgic patholog report autom inform extract effort focus specif cancer subtyp rather across multipl oncolog domain address gap develop evalu nlp method extract tumor stage diagnosi inform across multipl cancer subtyp

D010340

T091

sar cov childhood cancer diseas dispar pediatr oncolog covid case report registri suppli pediatr oncologist data surround clinic cours outcom children cancer sar cov

D054624

T080

ramap efflux pump regul carri inchi plasmid investig epidemiolog trend salmonella enterica serovar goldcoast previous identifi sever close relat strain differ mic azithromycin quinolon genom sequenc comparison two similar multidrug resist mdr strain r r led identif extra plasmid born rama gene ramap larg inchi plasmid carri r ramap gene locat bp region plasmid ident klebsiella quasipneumonia chromosom rama loci truncat ecp locat adjac upstream area putat regulatori region ramap may like contribut mobil express introduc ramap gene truncat ecp escherichia coli result elev express efflux pump gene elev mic chloramphenicol azithromycin nalidix acid ciprofloxacin sulfamethoxazol trimethoprim tetracyclin tigecyclin ramap extra efflux pump activ gene potenti could transmit inchi plasmid among bacteria plausibl high interspecif conserv plasmid encod regul reduc drug suscept activ exist efflux pump system host thus regard new type auxiliari antimicrobi resist determin sequenc similar plasmid found worldwid impact emerg antimicrobi resist among bacteri pathogen worrisom

D024901;D012486

T007;T032

assess antibiot toler staphylococcus aureus deriv direct patient replica plate toler isol system repti antibiot toler staphylococcus aureus pose great challeng clinician well microbiolog laboratori one reason treatment failur antibiot toler strain surviv transient antibiot exposur despit fulli suscept vitro thus fast reliabl method detect toler routin microbiolog laboratori urgent requir therefor evalu feasibl replica plate toler isol system repti detect antibiot toler staphylococcus aureus isol deriv direct patient suffer differ type infect investig possibl connect clinic present patient characterist one hundr twenti five aureus isol includ replica plate origin resist test plate use assess regrowth zone inhibit indic antibiot toler bacteri regrowth assess h incub overal regrowth score or assign regrowth score compar clinic present bacteri regrowth high antibiot target protein synthesi relat low antibiot target cellular function dna replic transcript cell wall synthesi except rifampin isol blaz penicillinas lower regrowth penicillin ampicillin low orss preval among isol recov patient immunosuppress methicillin resist aureus mrsa isol conclus repti use detect antibiot toler clinic microbiolog routin diagnost studi evalu impact rapid detect antibiot toler clinic decis make tool tailor antibiot treatment

D055624;D013203

T007;T047

effect troponoid mitochondri function cytotox hydroxytropolon hts troponoid inhibitor hepat b virus hbv replic target hbv rnase h submicromolar efficaci hts relat troponoid tropon tropolon cytotox cell line measur dimethylthiazol yl carboxymethoxyphenyl sulfophenyl h tetrazolium mts assay assess mitochondri function previous studi suggest tropolon induc cytotox inhibit mitochondri respir therefor screen divers troponoid effect mitochondri function mitochondrialnuclear genom ratio cytotox reactiv oxygen speci ros product troponoid class inhibit respir glycolysi although ketotropolon subclass interf process troponoid impact mitochondri dnanuclear dna ratio day compound exposur pattern troponoid induc cytotox among three hepat cell line similar compound three potent hbv rnase h inhibitor cytotox primari human hepatocyt tropolon hts increas ros product cell cytotox concentr effect lower concentr effici inhibit hbv replic troponoid mediat cytotox signific decreas upon addit ros scaveng n acetylcystein studi show troponoid increas ros product high concentr within cell line lead cytotox cytotox primari hepatocyt futur develop hts potenti therapeut hbv may need mitig ros product alter compound design andor coadminist ros antagonist amelior increas ros level

D006515;D014779

T005;T043

explor pharmacodynam pseudomona aeruginosa biofilm erad tobramycin pseudomona aeruginosa gram negat opportunist pathogen involv numer infect grow concern within field antibiot resist toler often exhibit multidrug resist previous studi shown emerg antibiot resist toler variant within zone clearanc biofilm lawn exposur aminoglycosid concern toler variant emerg also zone kill zok immedi surround antibiot sourc detect bacteria emerg cultur studi zok analyz use vitro silico method determin consist antibiot concentr versus time constraint area curv auc abl complet kill bacteria lawn biofilm vitro model studi reveal achiev averag auc ghml complet erad biofilm grown agar hydroxyapatit possibl find show appropri antibiot concentr treatment durat may abl treat antibiot resist toler biofilm infect

D011552;D014031

T195;T047;T109

predict antimicrobi resist clinic enterococcus faecium isol use rule base analysi whole genom sequenc enterococcus faecium major caus clinic infect often due multidrug resist mdr strain whole genom sequenc wgs power tool studi mdr bacteria antimicrobi resist amr mechan studi use wgs character e faecium clinic isol test feasibl rule base genotyp predict amr clinic isol divid deriv valid set phenotyp suscept test ampicillin vancomycin high level gentamicin ciprofloxacin levofloxacin doxycyclin tetracyclin linezolid perform use vitek autom system confirm discrep resolut broth microdilut disk diffus gradient diffus need wgs perform identifi isol lineag amr genotyp amr predict rule deriv analyz genotyp phenotyp relationship deriv set phylogenet analysi demonstr isol collect belong hospit associ clonal complex addit isol novel sequenc type appli valid set deriv predict rule demonstr overal posit predict valu negat predict valu compar standard phenotyp method error fals resist predict tetracyclin doxycyclin analysi genotyp phenotyp discrep reveal potenti novel pbp tet allel provid insight ampicillin tetracyclin class resist mechan predict rule demonstr generaliz test extern data set conclus known amr gene mutat predict e faecium phenotyp suscept high accuraci routin test antibiot provid opportun advanc molecular diagnost

D016984;D016908

T007;T047

safeti toler pharmacokinet pharmacodynam coadminist ruxolitinib artemeth lumefantrin healthi adult despit repeat malaria infect individu live area malaria endem remain vulner reinfect janus kinas jak inhibitor ruxolitinib could potenti disrupt parasit induc dysfunct immun respons administ antimalari therapi random singl blind placebo control singl center phase trial investig safeti toler pharmacokinet pharmacodynam profil ruxolitinib approv antimalari artemeth lumefantrin combin ruxolitinib pharmacodynam assess inhibit phosphoryl signal transduc activ transcript pstat eight healthi male femal particip age year random either ruxolitinib mg n placebo n administ h artemeth lumefantrin mg twice daili day mild advers event occur six particip four ruxolitinib two placebo combin artemeth lumefantrin ruxolitinib well toler advers event pharmacokinet consist known profil drug incid advers event artemeth dihydroartemisinin major activ metabolit artemeth lumefantrin exposur affect ruxolitinib coadministr ruxolitinib coadministr result fold greater pstat inhibit compar placebo geometr mean ratio confid interv direct predict relationship ruxolitinib plasma concentr pstat inhibit studi support investig combin artemeth lumefantrin ruxolitinib healthi volunt infect plasmodium falciparum malaria studi regist clinicaltrialsgov registr nct

D000962;D016778

T121;T047

potenc preclin evid synergi oral azol drug miltefosin ex vivo model leishmania viannia panamensi infect failur treatment cutan leishmaniasi antimoni drug miltefosin frequent use oral combin therapi repres attract strategi increas efficaci treatment reduc risk drug resist evalu potenc posaconazol itraconazol voriconazol fluconazol potenti synergi demonstr highest potenc combin miltefosin hepc infect leishmania viannia panamensi synergist activ determin isobologram calcul fraction inhibitori concentr index fici base parasit quantif use ex vivo model human peripher blood mononuclear cell pbmcs infect luciferas transfect antimoni miltefosin sensit line l panamensi drug combin concentr display synergi evalu antileishmani effect clinic strain l panamensi revers transcript quantit qrt pcr leishmania slrna high potenc substanti posaconazol itraconazol sensit well hepc antimoni resist line l panamensi wherea fluconazol voriconazol display low potenc hepc combin posaconazol poz demonstr evid synergi free drug concentr achiev plasma treatment hepc plus poz fici base reduct infect sensit line combin hepc plus poz effect signific greater reduct infect clinic strain l panamensi individu drug oral administr miltefosineposaconazol combin demonstr synergist antileishmani capac ex vivo l panamensi support potenti novel therapeut strategi improv efficaci effect treatment

D000981;D018334

T204;T121

emerg resist hiv integras dolutegravir treatment pediatr popul impaact p studi p multicent open label phase iii studi pharmacokinet safeti toler dolutegravir plus optim background regimen pediatr particip age week year hiv particip high treatment experienc report mechan emerg integras strand transfer inhibitor insti resist among adolesc children receiv dolutegravir plasma collect screen near protocol defin virolog failur pdvf popul level sampl clonal level integras genotyp phenotyp replic capac hiv rna assess avail plasma sampl phylogenet analysi clonal integras sequenc homolog model hiv intasom complex contain resist associ substitut perform treatment emerg insti resist detect particip met pdvf criteria rare insti resist associ substitut gr rk develop particip studi secondari integras substitut eq li observ particip gr reduc dolutegravir suscept integras replic capac rk demonstr greater reduct suscept integras replic capac present specif secondari integras substitut includ lm ti eek continu evolut rk acquisit led reduc dolutegravir suscept integras replic capac structur examin reveal potenti mechan gr rk mediat insti resist gr rk insti resist substitut distinct second generat insti detect adolesc children prior virolog failur receiv dolutegravir studi provid addit molecular structur character integras aid understand insti resist mechan antiretrovir experienc popul studi regist clinicaltrialsgov identifi nct

D015658;D019427;D019428

T116;T121;T126;T047

integras inhibitor resist mechan structur characterist antiretrovir therapi experienc integras inhibitor naiv adult hiv infect treat dolutegravir plus two nucleosid revers transcriptas inhibitor dawn studi week phase iiib dawn studi integras strand transfer inhibitor insti dolutegravir plus nucleosid revers transcriptas inhibitor demonstr superior ritonavir boost lopinavir achiev virolog suppress adult hiv fail first line therapi report emerg hiv drug resist mechanist underpin among dolutegravir treat adult dawn popul viral genotyp phenotyp clonal analys perform particip meet confirm virolog withdraw cvw criteria dolutegravir contain regimen dolutegravir bind structur chang hiv integras dna complex insti resist associ substitut evalu particip receiv dolutegravir week plus addit week assess met cvw criteria treatment emerg insti resist associ substitut rrk baselin cvw achiev hiv rna level copiesml achiev fold reduc viral replic capac versus baselin level studi demonstr pathway dolutegravir resist challeng balanc hiv phenotyp chang associ loss viral fit studi regist clinicaltrialsgov identifi nct

D015658;D019427;D019428;D015497

T005;T121;T047;T116;T126

interferon therapi chang natur cours hepat delta infect clinic patholog studi chronic delta hepat cdh wors outcom type viral hepat high dose long term alpha interferon ifn approv treatment may amelior cours infect evalu long term histolog outcom cdh patient treat ifn patient histolog prove noncirrhot cdh treat high dose ifn least year classifi cirrhot noncirrhot end treatment noncirrhot patient also posttreat liver biopsi patient design histolog respons nonrespons basi fibrosi status histolog virolog biochem cours analyz forti eight patient treat ifn convent andor pegyl median month posttreat follow year follow cirrhosi develop patient decompens differ pre posttreat fibrosi score noncirrhot patient end follow among patient n decreas n steadi n increas fibrosi score persist viral respons pvr achiev patient twenti percent entir group histolog respons decreas steadi fibrosi score improv necroinflammatori score near histolog progressioncirrhosi pvr signific associ histolog respons long term natur cours patient treat high dose ifn least year evalu clinic histolog despit associ pvr histolog respons ifn treatment chang natur cours cdh clinic histolog progress continu two third case despit treatment

D006505;D003699

T047

antifung load calcium sulfat bead potenti therapeut combat candida auri candida auri provid substanti global nosocomi threat clinic recent emerg organ readili colon skin nich like continu pose risk health care unit particular patient undergo surgeri purpos studi investig efficaci antifung load calcium sulfat cs bead combat c auri infect demonstr cs pack bead potenti interfer plankton sessil c auri

D000935;D000088063

T195;T121;T004

case commentari novel therapi multidrug resist acinetobact baumannii infect acinetobact baumannii pathogen bacterium common associ multidrug resist issu antimicrobi agent chemotherapi challeng case ventil associ pneumonia present bacteriophag therapi use last resort treatment combin system antibiot data promis sever key area highlight futur research

D000151;D040981;D053717

T007;T047

clinic outcom ertapenem pneumonia obes versus nonobes patient object studi compar rate pneumonia resolut obes bodi mass index bmi kgm nonobes bmi kgm patient treat gram ertapenem daili retrospect cohort studi evalu patient treat ohio state univers wexner medic center januari august patient includ year old receiv ertapenem least hour pneumonia treatment patient exclud pregnant incarcer renal impair receiv antibiot gram negat activ signific period prior addit ertapenem concomit deep seat infect primari outcom clinic resolut defin meet follow three criteria order evalu discontinu antibiot day therapi afebril ertapenem addit decreas white blood cell count improv chest radiograph day therapi multivari logist regress analysi perform examin associ obes clinic resolut adjust proven confound nonobes obes patient includ median patient bmi kgm kgm nonobes obes cohort respect clinic resolut achiev nonobes obes patient p without observ differ regress model outcom similar obes nonobes patient treat gram ertapenem daili pneumonia

D009765;D011014

T050;T047

safeti toler pharmacokinet telacebec q new antituberculosi agent healthi subject telacebec q potent drug candid clinic develop treatment drug nave drug resist tuberculosi first human random placebo control doubl blind dose escal phase trial q tb pi us conduct evalu safeti toler pharmacokinet telacebec total normal healthi male femal subject activ placebo enrol studi dose telacebec mg cohort mg cohort mg cohort mg cohort mg cohort mg cohort mg cohort fast state subject particip cohort also enrol cohort investig food effect pharmacokinet telacebec high fat meal subject dose telacebec mg telacebec well toler lead signific serious advers event follow singl oral administr telacebec mg telacebec plasma concentr reach maxim plasma concentr c max averag h show multi exponenti declin thereaft area plasma concentr versus time curv auc approxim dose proport signific increas plasma concentr observ fed condit compar fast condit geometr mean ratio c max moder delay max h also observ fed condit result combin demonstr activ drug sensit multidrug resist mycobacterium tuberculosi support investig telacebec treatment tuberculosi

D010880;D011725

T109

compar analysi plasmodium falciparum genotyp via snp detect microsatellit profil whole genom sequenc research effort combat antimalari drug resist reli quick robust sensit method genet character plasmodium falciparum parasit develop singl nucleotid polymorph snp base genotyp method assess drug resist confer snps dhfr dhps pfmdr pfcrt k nine pcrs perform direct p falciparum cultur infect blood also optim multiplex fragment analysi gel electrophoresi base microsatellit type method use set five marker distinguish laboratori strain divers geograph tempor origin demonstr method appli screen multidrug resist kelplapfpailin kelpp lineag sweep across greater mekong subregion verifi parasit vitro snp edit identifi novel recombin genet cross progeni cluster strain infer geograph origin result compar illumina base whole genom sequenc analysi provid detail sequenc inform cost prohibit adapt simpl inexpens method easili implement routin genotyp p falciparum parasit laboratori field set

D000962;D016778

T121;T047

synergi mechan daptomycin fosfomycin combin daptomycin suscept resist methicillin resist staphylococcus aureus vitro ex vivo vivo metric increas usag daptomycin dap methicillin resist staphylococcus aureus mrsa infect led emerg dap resist dap r strain result treatment failur dap fosfomycin fosfo combin synergist activ mrsa although mechan interact fulli understood current studi explor four uniqu like interrel activ dap fosfo combin synergist kill ii prevent evolut dap r iii resensit alreadi dap r subpopul dap suscept dap phenotyp iv perturb specif cell envelop phenotyp known correl dap r mrsa use isogen dap cb dap r cb clinic mrsa strain pair demonstr combin dap plus fosfo dapfosfo enhanc kill strain vitro ex vivo ii increas target tissu clearanc dap r strain vivo model experiment infect endocard ie iii prevent emerg dap r dap parent strain vitro ex vivo iv resensit dap r strain dap phenotyp ex vivo phenotyp follow exposur sub mic fosfo dap sdap r strain pair exhibit distinct modif net posit surfac charg p ii quantiti p local cell membran cardiolipin cl iii dap surfac bind iv membran fluiditi p furthermor precondit strain pair dap without fosfo dap fosfo sensit organ kill human host defens peptid data underscor notion dap fosfo combin impact mrsa clearanc within multipl microenviron like base specif phenotyp adapt

D017576;D005578;D055624;D013203

T195;T047;T007;T116;T109

effect capsaicin atom induc cough sputum excret tracheotom patient hemorrhag stroke random control trial background time effect remov respiratori secret great signific tracheotom patient purpos studi investig effect capsaicin nebul stimul cough promot earli clearanc respiratori secret tracheotom patient hemorrhag stroke method studi implement random control design sixti three patient tracheotom follow hemorrhag stroke complet random control trial control group case given routin care tracheotomi intervent group case given capsaicin solut nebul addit routin care daili sputum output number sputum suction observ differ sputum viscos cough function clinic pulmonari infect score cpis compar two group intervent vital sign chang capsaicin nebul suction compar two group pilot studi result daili sputum output capsaicin intervent group signific higher control group p number sputum suction capsaicin group less control group intervent p cpis score capsaicin group lower control group p conclus capsaicin atom induc cough effect promot sputum excret hemorrhag stroke patient undergo tracheotomi good safeti profil clinic trial registr number studi chictr http wwwchictrorgcn supplement materi https doiorgasha

D002211;D000083302

T121;T047;T109

discours perform adult mild traumat brain injuri orthoped injuri moder sever traumat brain injuri healthi control adult mild traumat brain injuri mtbi risk communic disord yet studi explor cognit communic perform current lack

D001924;D000070642

T037

gata gata bind protein kmta lysin methyltransferas complex increas hk trimethyl lysin histon upregul ncx na ca exchang transcript contribut ischem precondit neuroprotect ncx na ca exchang play relev role stroke inde pharmacolog blockad genet ablat exacerb brain ischem damag wherea upregul take part neuroprotect elicit ischem precondit identifi effect strategi induc overexpress ncx examin transcript factor epigenet mechan potenti involv ncx gene regul

D019194

T061

diversifi neighborhood school engend percept foreign cultur threat among white american nation repres survey n five experi four preregist total n reveal white perceiv foreign cultur threat threat american cultur way life project growth racial ethnic minor popul major white neighborhood studi school studi white perceiv increas presenc arab american latino asian american pose especi strong degre perceiv foreign cultur threat relat black american perceiv threaten demograph chang furthermor percept foreign cultur threat predict white desir move beyond establish intergroup threat eg realist symbol threat find highlight white concern lose american cultur way life racial ethnic minor group enter major white neighborhood school may contribut mainten racial segreg psycinfo databas record c apa right reserv

D005006;D008913

T102;T098

preferenti forgiv impact group membership remors preschool forgiv forgiv help repair ruptur relationship maintain cooper may use serv function preferenti direct toward better cooper examin propos two studi young children studi ask whether children forgiv group member peopl general expect cooper group member novel group member group member transgress child show remors year old children n forgiv group member studi group transgressor remors wherea group transgressor unremors demonstr cooper intent year old n forgiv remors group transgressor children also judg unremors group transgressor negat want leav group togeth result reveal earli life forgiv preferenti direct maxim success cooper reduc risk exploit psycinfo databas record c apa right reserv

D061347

T078

sens bodi ownership shape visual represent bodi size conscious bodi imag includ visual represent bodi part size whether compon bodi percept flexibl adapt chang sens ownership one bodi part remain demonstr present studi address issu show ownership novel hand affect conscious visual percept size realli own hand seri experi healthi adult assess embodi fake hand differ size ie rubber hand illus rhi affect visual size estim hand result demonstr embodi fake hand bigger size hand experi smaller fake hand experi affect percept similar size hand visual model hand tendenc toward overestim size hand expos rhi experi illusori ownership bigger hand affect visual estim object size experi find show tight link bodi imag sens ownership latter abl chang store represent bodi part size evid might pave way restor patholog alter bodi imag strategi access bodi schema psycinfo databas record c apa right reserv

D001828;D049628;D010067;D014796

T080;T041;T081;T032;T078

pandem polit person role conscienti polit ideolog share fake news share misinform catastroph especi time nation import typic studi polit context share fake news posit link conserv polit ideolog howev sweep general run risk increas alreadi rampant polit polar offer nuanc account propos share fake news larg driven low conscienti conserv high level conscienti differ liber conserv find support hypothes context covid polit neutral news across eight studi six preregist two conceptu replic particip uniqu particip news observ general desir chao explain interact effect polit ideolog conscienti share fake news furthermor find indic inadequaci fact checker intervent deter spread fake news underscor challeng associ tackl fake news especi crisi like covid misinform impair abil govern curtail pandem psycinfo databas record c apa right reserv

D000086382;D058873

T047;T067

articul contribut valenc sound symbol vowel sound symbol associ valenc specif word contain vs judg suitabl denot posit vs negat object examin psycholog process drive valenc sound symbol test compet predict vowel articulatori hypothesi predict associ negat valenc articul inhibit smile pitch base hypothesi predict associ posit valenc high intrins pitch four experi associ posit valenc read experi hear word experi negat valenc compar support articulatori hypothesi similar even negat valenc compar contradict pitch base hypothesi thus present find suggest valenc sound symbol basi rather articulatori auditori phonem properti advanc understand psycholog process valenc vowel associ sound symbol general psycinfo databas record c apa right reserv

D001334;D013561

T056;T041

thought dynam task demand evalu influenc task difficulti unconstrain thought research mind wander acceler construct defin featur expand research begun examin differ dimens mind wander recent christoff colleagu argu import investig hitherto neglect varieti mind wander unconstrain thought thought relat unguid execut control process date studi investig unconstrain thought littl known intrigu type mind wander across experi examin first time whether chang task demand influenc rate constrain versus unconstrain thought experi particip complet either easi back hard back task respond intermitt present thought probe gaug thought constraint throughout task experi found particip complet easi task engag unconstrain thought frequent complet difficult task experi replic result demonstr manipul unconstrain thought also measur task related common dimens mind wander final exploratori analys show associ constrain thought age verbal intellig assess flow deep effortless concentr therebi ad evid indic dissoci task related constraint discuss methodolog theoret applic find burgeon field research unconstrain thought data analysi articl experi code found https osfiowrvk psycinfo databas record c apa right reserv

D001288;D056344

T041

distractor distractor interact visual search orient target explain increas difficulti observ nonlinear separ condit linear separ effect refer benefit search perform observ featur search task target distractor featur vari along continu featur dimens search perform best boundari featur space separ distractor featur target featur howev role distractor heterogen play effect well understood reexamin effect context new predict procedur llera et al quantifi impact distractor heterogen search perform experi b measur peopl perform homogen search condit search target among one type distractor paramet observ experi b use predict search time experi target present heterogen display contain two type distractor result show total varianc account without includ factor index linear separ rule result demonstr heterogen search orient space function target distractor similar interitem interact studi highlight robust predict procedur demonstr generaliz method estim interitem interact new stimulus type psycinfo databas record c apa right reserv

D001288;D014796

T041

repres action term evid inhibitori code multipl action control perform two action time vs isol usual result perform cost howev recent studi report also possibl observ dual action benefit find challeng standard theori multipl action control issu typic resolv assum certain circumst perform one two possibl action cognit repres term necessit cost stop initi activ unwarr second action test hypothesi altern inhibitori code account rest assumpt action might cognit repres term across four experi particip respond singl stimulus either singl dual respons manual vocal domain relat frequenc respons type systemat manipul result reveal robust dual action benefit manual respons time error rate pattern across experi clear support novel inhibitori code framework crucial impli even though motor action requir singl dual respons physic repres differ specif dual respons repres holist noncomposit overal find demonstr astonish flexibl mental represent behavior demand psycinfo databas record c apa right reserv

D011597;D014831

T040;T041

visual percept appar motion abid minim principl geometri appar motion robust perceptu phenomenon observ perceiv stimulus travers vacant visual space two flash stimuli although known fill appar motion favor simplest econom path interpol comput remain poor understood test whether percept appar motion best character newtonian physic kinemat geometri particip complet target detect task pacmen shape object present success creat percept appar motion found target detect impair appar motion predict kinemat geometri newtonian physic obstruct target locat find shed light comput employ visual system suggest specif fill percept appar motion may domin kinemat geometri newtonian physic psycinfo databas record c apa right reserv

D009039

T041

social attent trigger eye gaze walk direct resist tempor decay attent orient induc social cue eye gaze walk direct biolog motion play vital role human surviv interperson interact long debat whether indispens abil uniqu intrins distinct nonsoci attent current studi character tempor profil attent orient trigger social cue ie eye gaze walk direct compar induc nonsoci cue ie arrow exogen cue use covert orient task calcul attent cu effect earli late period task carri time cours analysi character dynam chang trial wherea cu effect induc nonsoci cue exhibit signific trend tempor decay cu effect induc two differ social cue similar remain stabl throughout task resembl induc reflex exogen cue result clear demonstr social coordin attent orient high reflex tempor stabl respons less suscept top cognit control substanti distinguish attent orient induc nonsoci cue find extend understand distinct social nonsoci attent substanti specif social attent orient tempor stabil perspect psycinfo databas record c apa right reserv

D005403;D016138

T056;T042;T169

instruct nt help know optim strategi facilit rule base inform integr categori learn provid verbal written instruct perform optim task one common way teach beginn practic wide accept scholarship primarili focus provid instruct whether instruct help investig benefit prior instruct rule base rb categori learn optim strategi simpl explicit rule inform integr ii categori learn optim strategi similar base particip n learn either rb ii categori without verbal written instruct optim categor strategi instruct signific improv perform rb categori effect ii categori theoret practic implic result discuss psycinfo databas record c apa right reserv

D007858

T041;T061;T062

observ perspect determin cue use interpret point gestur though ubiquit human communic point gestur often misunderstood studi address observ perspect affect point percept specif test hypothesi two differ visual cue name vector defin pointer arm finger b pointer index finger posit observ visual field determin point percept relat influenc depend observ perspect three experi particip judg locat virtual real pointer point differ viewpoint experi show observ perspect consider effect point percept observ gaze direct align point arm observ reli posit point finger visual field less reli direct psycinfo databas record c apa right reserv

D003463;D005868

T054;T078

chang bias identifi featur drive time percept time percept malleabl perceiv durat stimuli strong affect sensori respons evok tempor illus provid window differ sensori system contribut sens time evid suggest sensori respons differ featur affect time percept differ extent mediat level arous surpris evok howev make difficult disentangl effect sensori respons deriv arous surpris effect demonstr time percept differenti affect differ stimulus featur arous surpris kept constant four tempor discrimin experi particip present empti interv mark two briefli present visual marker stimuli judg whether durat longer shorter refer marker either repeat chang along one six featur dimens manner fulli predict particip repetit chang would modul sensori respons magnitud due neural repetit suppress result show interv perceiv longer marker chang locat size numeros convers chang face ident orient lumin affect time percept result point neural function select way differ stimulus featur affect time percept psycinfo databas record c apa right reserv

D007088;D013998

T048;T041;T033

attent guidanc irrelev featur depend success encod work memori attent select guid templat target work memori propos attent templat integr target featur eg purpl chair guid attent object base fashion altern may attent templat establish target featur individu eg purpl chair provid support latter account use task particip memor target shape ignor irrelev color combin condit shape shown irrelev color separ condit irrelev color spatial separ shape initi present blank retent interv particip ask make saccad initi view shape shown togeth distractor attent guidanc irrelev color strong reduc separ present suggest guidanc object base howev may irrelev color less reliabl encod separ present therefor ask particip store irrelev color later recal addit memori task guidanc irrelev color occur regardless whether present part object separ thus effect irrelev featur easier observ combin present featur object automat encod work memori form integr featur templat nonetheless guidanc separ featur possibl poor encod irrelev featur separ present make difficult observ psycinfo databas record c apa right reserv

D008570;D014796

T041

perceptu load enumer distractor interfer depend subit capac attent limit process capac lead phenomena inattent blind capac select focus lead distract load theori eg lavi account limit propos perceptu process limit capac proceed automat parallel stimuli within capac test claim appli load theori phenomenon subit parallel detect individu limit number item establish enumer research predict distractor interfer found within beyond person subit capac measur transit parallel serial slope particip report number target shape brief display ignor irrelev cartoon imag distractor predict distractor cost enumer perform found within subit capac elimin larger set size moreov individu differ result demonstr distractor effect depend individu capac ie serial parallel transit point rather set size per se result provid new evid load theori hypothes perceptu process automat parallel within limit capac extend account select attent enumer psycinfo databas record c apa right reserv

D001288;D010364

T041

examin psychometr properti integr hope scale english translat mix diagnost communiti health sampl object provid preliminari evid english translat integr hope scale ih hope critic concept recoveri synthes hope model schrank colleagu develop ih although translat five languag known studi assess ih english translat within clinic sampl addit known studi investig ih relationship mental health measur mix diagnost clinic sampl

D007802;D011634

T171;T091

semant syntax interfac learn grammat categori hierarch syntact structur semant languag infinit product syntax defin depend grammat categori word constitu interchang word constitu within syntact structur previous laboratori base studi languag learn shown complex languag structur like hierarch center embed hce hard learn studi tend simplifi languag learn task omit semant focus either learn depend individu word acquir categori membership word test whether categori word depend categori constitu could learn simultan artifici languag hce accompani scene illustr sentenc intend mean across four experi show particip abl learn hce languag vari word across categori categori depend constitu across constitu depend also abl general learn structur novel sentenc novel scene previous experienc simultan learn result product complex languag system may consequ ground complex syntax acquisit semant psycinfo databas record c apa right reserv

D007804;D012660

T041;T078

gleam glum effect versus phonem generic carri emot valenc gleam glum effect novel sound symbol find word phonem like gleam perceiv posit emot match word phonem like glum provid data confirm effect also consist explan articul tend co occur activ posit versus negat emot facial musculatur respect three studi elimin select bias includ applic english word english lexicon project balota et al warrin et al databas everi possibl mandarin pinyin combin differ middl phonem vs studi us undergradu rate monosyllab english word robust posit match word studi analyz warrin et al valenc rate extend gleam glum effect applic word databas studi us particip use english particip china use mandarin pinyin rate word pair three condit moder musculatur activ read aloud enhanc read silent control read silent chew gum interfer inde effect replic signific larger facial musculatur enhanc interf two languag popul signific differ find confirm robust gleam glum effect despit semant nois english mandarin pinyin furthermor data consist hypothesi type sound symbol aris overlap muscl use articul emot express psycinfo databas record c apa right reserv

D004644;D007802

T041;T171

good bad prime self trigger posit negat implicit evalu although theori person human behavior long assum self affect complex wide use indirect measur implicit self evalu larg focus robust cultur univers self posit indirect measur assess evalu singl continuum rang posit negat thus focus self relat posit inher incap assess whether self associ good bad use well establish evalu prime task present work test hypothesi posit implicit self evalu coexist inkl negat implicit self evalu studi empir demonstr prime self facilit classif posit negat target bival prime contrast replic classic find prime person signific like object facilit classif posit target inhibit classif negat target unival prime studi show bival prime trigger self prime explain altern account eg arous vigil meta analys studi attest robust reproduc self prime trigger posit negat implicit evalu moreov test estim heterogen strength implicit self evalu indic individu differ nonclin healthi individu may limit possibl reflect measur limit natur implicit self evalu overal present work shine spotlight previous undocu effect despit self robust net posit self reliabl trigger negat implicit self evalu implic conceptu assess consequ implicit self evalu discuss psycinfo databas record c apa right reserv

D012647

T055;T041

distinct visual resolut support apertur shape natur pantomim grasp pantomim grasp simul motor respons wherein individu grasp area dissoci physic target task use apraxia literatur proxi natur grasp ie physic grasp target howev import recogn task decoupl spatial relat stimulus respons render top process target featur eg size accumul evid shown mediat visual inform function distinct natur grasp examin whether visual inform support pantomim grasp exhibit visual resolut power commensur natur grasp particip present target nontarget differ size perceptu threshold ie mm ask make perceptu judgment target ie smaller larger nontarget complet natur pantomim grasp result show perceptu judgment natur pantomim grasp reliabl distinguish target nontarget natur grasp peak grip apertur pgas scale target size compar perceptu judgment trial result indic haptic feedback physic grasp target boost perceptu accuraci notabl pantomim grasp pgas insensit target size respons elicit visual resolut power less natur grasp result provid converg evid pantomim grasp mediat visual inform obligatori percept provid proxi natur grasp psycinfo databas record c apa right reserv

D056228;D011597

T041;T067

subject age attitud toward age across two decad histor time larg bodi empir evid accumul show experi old age younger agent happier ever howev yet known whether histor improv well control belief cognit function outcom general individu view age process examin histor chang view age compar match cohort older adult within two independ studi assess differ across two decad interv berlin age studi base vs n age midlif unit state studi midus vs n age consist across four differ dimens individu subject view age age felt age appear desir age attitud toward age base corrobor subject age felt subject age desir midus evid whatsoev older adult today favor view age older adult two decad ago heterogen view age increas across two decad midus decreas base also consist across studi associ view age sociodemograph health cognit psychosoci correl chang across histor time discuss possibl reason find includ possibl individu age view may becom increas decoupl societ age view psycinfo databas record c apa right reserv

D000375;D001290

T040;T033;T041;T055;T078

mother father attach style power assert control indirect associ parent represent research adult self report attach style investig most social person psycholog rare bridg research parent studi most development psycholog propos parent attach insecur avoid anxieti indirect associ power assert control mediat negat represent intern work model iwm child communiti famili midwestern state mother father children collect multimethod parallel data mother child father child relationship children infant parent complet self report attach style children toddler assess parent iwm child interview observ parent power assert control structur naturalist disciplin context laboratori mother avoid show uniqu associ iwm child consequ indirect associ mother avoid negat iwm power assert control mother anxieti associ direct power assert control father avoid anxieti also associ iwm uniqu associ impact parent limit forg rapproch social person research adult attach development research parent work elucid potenti mechan intergener transmiss adapt maladapt parent famili psycinfo databas record c apa right reserv

D005220;D009035

T092;T099

famili vulner disrupt chao predict parent child covid health protect behavior adher studi examin role famili function predict famili adher health protect behavior hpbs aim reduc covid spread pre covid famili function disrupt famili function cohes conflict routin famili chao covid pandem test pathway hpb adher

D000086382

T047;T067

impact leader domin employe zero sum mindset help behavior leader strive encourag help behavior among employe posit affect organiz team effect howev manner leader influenc other unintent limit desir behavior draw social learn theori contend leader tendenc influenc other via domin could decreas employe interperson help domin leader influenc other assert competit shape subordin cognit schema success base zero sum think employe zero sum mindset like believ make progress expens other propos zero sum mindset result less interperson help among subordin test hypothes employ differ operation key variabl eight studi four report manuscript anoth four supplement inform across combin sampl observ studi includ larg archiv studi experi laboratori onlin sampl time lag field studi employe differ team overal research highlight unintend consequ domin leader follow help behavior increas zero sum mindset psycinfo databas record c apa right reserv

D006379;D007857

T054;T078

relat aspect vicari retribut evid profession basebal act negat reciproc generat destruct sequenc repris basebal hit batter pitch general repres vicari form retribut behalf teammat understand practic prone escal examin dyadic relationship team characterist influenc punit aggress game construct suit indic variabl data two decad play enabl us track shift state relat account oppos team even though motiv engag retribut may exist logist regress establish curb limit escal beyond initi exchang sequenc game aspect dyadic relationship pitcher teammat enhanc intent take vicari retribut relationship oppos batter exert countervail forc aggress find yield insight origin evolut intergroup conflict implic theori conflict organiz practic psycinfo databas record c apa right reserv

D001484

T056;T073

error task switch investig error aftereffect n repetit cost paradigm studi switch task studi error commiss provid solid behavior measur execut control nonetheless gap remain strand research three experi sought reduc gap assess impact task error n repetit cost effect suppos relat task set inhibit base previous literatur report task switch benefit follow task error due incident learn erron execut task set predict n repetit cost decreas task error trial n relat correct respons furthermor predict effect present correct control mechan would time build post error trial ie follow fast post error trial hypothesi test three task paradigm use incongru stimuli assumpt error trial part due task confus consist predict n repetit cost follow n error found reduc respons trial n fast present n respons slow taken togeth result suggest task execut lead associ strengthen correspond task set irrespect respons accuraci automat strengthen counteract slowli act control mechan psycinfo databas record c apa right reserv

D056344;D011597

T041

laboratori studi naturalist second languag learn acquir grammat gender simpl dialogu aim studi twofold first develop experiment techniqu tool investig learn outcom spontan naturalist second languag l learn control laboratori condit second explor techniqu use understand basic condit limit learn two variant dialogu game test correct l input provid learner learn aspect camouflag particip german learner dutch known display persist grammat gender error dutch owe incorrect first languag l l transfer experi particip virtual partner audio record took turn describ card use gender mark articl noun phrase howev major particip becam awar learn articl goal experi either way ask particip goal experi task use therefor chang aspect use dialogu memori game experi inde led minor suspect real goal studi experi particip show substanti learn word gender averag percentag point increas accuraci one instanc correct input manipul number trial lag correct input product affect result furthermor nave particip experi show much learn full sampl thus new paradigm offer import insight determin naturalist learn psycinfo databas record c apa right reserv

D019303

T171

multilevel meta analysi causal effect approxim number system train symbol math perform perform meta analysi approxim number system an train studi investig strength causal effect practic an relat task symbol math perform across effect size studi involv particip neither treatment control group receiv symbol train found small nonsignific sensit effect an train symbol math task perform g confid interv ci precis effect estim standard error pees adjust g ci heterogen account particip age larger estim adult children estim vari signific an train type train durat control group type exploratori analysi transfer effect an train untrain nonsymbol task suggest weak support key auxiliari assumpt an train substanti effect general an indic train literatur may adequ repres theori an influenc symbol number perform psycinfo databas record c apa right reserv

D007802;D013647

T057;T061;T171

peopl hold mood congruent belief memori use belief monitor learn contemporari theori metacognit monitor propos belief play critic role monitor learn even recent evid suggest belief alway suffici impact peopl monitor seven experi explor peopl belief impact mood item valenc memori whether peopl use belief cue monitor learn particip express mood congruent belief experi believ peopl negat mood would rememb negat item posit neutral item evalu whether use belief monitor learn particip studi emot posit negat neutral pictur experi word experi made judgment learn jol complet free recal test experi particip complet learn task negat neutral mood negat mood induc establish mood induct procedur contrast belief base hypothesi particip make mood congruent jol jol influenc mood contrast jol consist higher emot relat neutral item thus although particip demonstr mood congruent belief use belief monitor learn outcom demonstr simpli belief person center cue eg belief impact person mood memori suffici belief impact monitor learn psycinfo databas record c apa right reserv

D007858;D000067489

T041;T061;T062

frame fake news asymmetr attribut frame bias favor unfavor outcom attribut frame bias afb refer addresse bias evalu posit frame object success favor negat frame one failur although logic equival novelti current studi examin condit afb occur occur typic afb examin favor outcom eg success failur current studi extend examin unfavor outcom eg failur success accord fuzzi trace theori inform encod detail verbatim represent fuzzi gist represent afb elicit vagu gist represent maintain either posit negat valenc messag current studi offer novel insight relationship gist verbatim represent afb examin moder favor outcom three experi focus perceiv reliabl news item fake news becom issu major concern news media publish truth evalu howev frame evalu may bias perceiv reliabl news henc examin extent favor outcom moder afb perceiv news reliabl result show attribut frame bias perceiv reliabl news truth outcom favor true fake outcom unfavor true fake discuss theoret implic find understand afb practic implic concern perceiv reliabl news psycinfo databas record c apa right reserv

D000087862;D046152

T080;T191

minim impact consolid learn switch readi adapt behavior character abil creat maintain updat switch rule categor respond stimuli across chang context cognit flexibl recent research suggest peopl link control process task switch contextu cue associ learn wherebi behavior cost switch reduc context requir frequent switch one exampl listwid proport switch lwps effect denot smaller switch cost block trial switch frequent howev condit govern learn cognit flexibl poor understood one major unansw question whether type learn benefit memori consolid effect address question manipul whether task set andor specif task stimuli frequent link task switch vs repeat ran particip two experiment session separ hr delay expect consolid would facilit learn cognit flexibl result greater reduct switch cost increas task switch likelihood session compar session across two experi observ robust lwps effect session howev found littl evid effect consolid learn cognit flexibl magnitud lwps effect chang session altogeth result suggest peopl reliabl quick acquir task set stimulus base switch associ form control learn unlik mani instanc reward base learn benefit long term memori consolid possibl reason find discuss psycinfo databas record c apa right reserv

D007858;D011597

T041;T061;T062

conflict interfer insect respons conflict occur correct goal congruent respons weaker altern incorrect respons overcom respons conflict stronger respons inhibit make studi respons conflict import research topic higher order cognit respons conflict often result conflict interfer increas error rate respons time ask whether invertebr ant lasius niger solv respons conflict whether suffer conflict interfer also ask whether ant show congruenc sequenc effect subject show transient reduc conflict infer conflict repeat develop task mimick aspect stroop color word test ant must learn follow neutral cue scent maze ignor domin innat meaning signal pheromon trail pheromon congruent scent cue lead maze arm incongru accuraci task solv latenc suffer inform sourc incongru evid congruenc sequenc effect limit experiment design rule insect would also show congruenc sequenc effect differ experiment paradigm although methodolog direct compar human studi presenc clear conflict interfer suggest parallel insect human inform process spite complet differ brain power straightforward methodolog open possibl explor conflict interfer presenc prepot respons tendenc invertebr model hope work encourag field respons competit use vast literatur respons competit anim behavior studi psycinfo databas record c apa right reserv

D003220;D010675

T055;T123

race toward fast effect isotop label nuclear magnet reson spectroscopi n formyl mlf oh associ build block solid state h c n nuclear magnet reson nmr spectroscopi essenti analyt method studi complex molecul biomolecul decad oxygen nmr ideal robust candid studi hydrogen bond within secondari tertiari protein structur exampl continu elud mani discuss improv multipl turnov label procedur develop fast cost effect method label fluoroenylmethyloxycarbonyl fmoc protect amino acid build block approach allow inexpens usdmg insert label import barrier overcom futur biomolecular studi nmr result build block site specif strategi label n acetyl mlf oh n formyl mlf oh tripeptid present showcas growth nmr develop maxim sensit gain use emerg sensit enhanc techniqu includ popul transfer high field dynam nuclear polar cross polar magic angl spin cryoprob

D000596;D011506

T116;T121;T123

synthesi azidoanilin buchwald hartwig amin report buchwald hartwig amin compat azido function treatment azidoaryl iodid amin fourth generat buchwald precatalyst coordin cphos sodium tert butoxid dioxan c afford correspond azidoanilin leav azido group intact method show broad substrat scope applic synthesi diazido compound photoaffin probe candid pharmaceut amin multiazido platform molecul

D000588

T109

dival metal ion select crispr cas system associ cas protein insight classic molecular dynam simul electron structur calcul crispr associ protein cas univers conserv essenti metalloenzym cluster regular interspac short palindrom repeat crispr immun system prokaryot bacteria archaea cut integr part viral dna host genom help protein integr dna act memori viral infect transcrib rna stop futur infect recognit base rnadna complementar principl follow protein mediat degrad viral dna propos presenc singl manganes mn ion conserv dival metal ion bind pocket key residu e h cas crucial function cas mediat dna degrad propos hinder metal substitut metal chelat mutat bind pocket residu cas activ toward dsdna degrad mn mg x ray structur cas reveal intric atom interact network dival metal ion bind pocket open possibl model relat metal ion viz mg ca bind pocket wild type wt mutat cas protein comput analysi includ quantit estim energet dival metal ion prefer explor structur dynam aspect protein respons dival metal ion substitut amino acid mutat use x ray structur cas protein pseudomona aeruginosa templat pdb god perform classic molecular dynam md simul compar structur dynam differ mg ca bound bind pocket wild type wt mutant ea ha da da cas furthermor reduc bind pocket model generat x ray molecular dynam md trajectori result structur subject quantum chemic calcul result suggest cas prefer mg bind relat ca prefer strongest wt weakest da mutant quantum chemic calcul indic mn prefer relat mg ca wild type mutant cas substitut mg ca alter interact network cas dival metal ion increas wet bind pocket introduc singl water molecul first coordin shell latter strength metal ion prefer mg versus ca seem depend solvent access dival metal ion bind pocket strongest wild type cas metal ion bind pocket dri includ two water molecul weakest da mutant metal ion bind pocket wet includ four water molecul

D064130

T116;T123

electron level structur novel guanin octuplex dna singl molecul throughout past decad guanin quadruplex dna structur attract much interest fundament materi scienc perspect technolog orient perspect novel guanin octuplex dna form coil quadruplex dna recent discov stabl rigid dna base nanostructur detail electron structur studi new nanomateri perform scan tunnel spectroscopi subsingl molecul level cryogen temperatur present herein electron level lower energi gap guanin octuplex dna compar quadruplex dna dictat higher transvers conduct guanin octad guanin tetrad

D054856;D049329

T086;T073

structur base relat energi predict model case studi pd ii catalyz ethylen polymer electron effect ancillari ligand rapid map reaction energi profil understand reaction mechan great import high desir discoveri new chemic reaction herein combin densiti function theori dft calcul regress analysi appli construct quantit structur base energi predict model consid pd ii catalyz ethylen polymer exampl rapid construct reaction energi profil inspir geometr paramet reaction center one speci capabl predict whole energi profil high accuraci reaction energi ethylen insert h elimin direct correl polymer activ possibl branch format studi elucid electron effect ancillari ligand analys model statist chemic point view afford use inform design catalyst ligand current work expect methodolog shed new light rapid map energi profil chemic reaction provid use inform develop reaction

D004581;D005030

T090;T109

synergist effect natur compound toward inhibit sar cov cl proteas biggest challeng medic manag control covid pandem nonavail treatment molecul vaccin biotherapeut product manag covid reach market small molecul cure yet develop relev cost product storag eas distribut small molecul drug signific favor biolog paper present multicompound approach two drug molecul administ concurr offer effect therapi covid co action two compound deriv natur origin demonstr cl proteas alreadi recogn potenti drug target inhibit sar cov pair compound pursu studi flavonoid naphthalen scaffold individu offer inhibit comprehens dock molecular dynam simul elucid compound exhibit excel bind process howev quick deterior ligand separ bind site suggest ligand initi bind proteas unabl maintain extend period howev simul show simultan dock complex compound togeth protein boost stronger bind suffici time enzym assay exhibit inhibit activ compound use togeth respect later multiconcentr assay use determin coinhibitori activ observ compound inhibit activ even lower concentr surfac plasmon reson use measur bind compound use togeth compound fold greater bind affin thus result demonstr synergist mechan two compound enhanc inhibit activ sar cov cl proteas

D000086382;D000086782;D000086402

T005;T047;T116;T126;T067

function polyhydroquinolin amino acid use key one pot cyclize cascad applic synthesi mesembrenon substitut polyhydroquinolin ubiquit skelet core found drug bioactiv natur product new rout access motif success develop one pot cyclize cascad high chemocontrol diastereoselect sequenc generat two cycl three carbon carbon bond carbon quaternari center high converg process function polyhydroquinolin congen access commerci avail amino acid versatil robust strategi appli synthesi mesembrenon

D026121

T121;T109

nextorch design bayesian optim toolkit chemic scienc engin autom optim chemic system requir well inform decis experi run reduc time materi andor comput data driven activ learn algorithm emerg valuabl tool solv task bayesian optim sequenti global optim approach popular activ learn framework past studi demonstr effici solv chemistri engin problem introduc nextorch librari pythonpytorch facilit laboratori comput design use bayesian optim nextorch offer fast predict model flexibl optim loop visual capabl easi interfac legaci softwar multipl type paramet data type convers provid gpu acceler parallel state art bayesian optim algorithm support autom human loop optim comprehens onlin document introduc bayesian optim theori sever exampl catalyst synthesi reaction condit optim paramet estim reactor geometri optim nextorch open sourc avail github

D000465;D012984

T170;T090;T073

genomewid transcriptom respons arthrobact simplex cortison acet mutant enhanc dehydrogen effici due superior dehydrogen abil arthrobact simplex wide use biotransform cortison acet ca prednison acet pa steroid industri howev molecular fundament still unclear herein genom organ gene regul previous unreport gene involv dehydrogen reveal genom transcriptom analysi compar studi transcriptom industri strain induc ca differ biotransform period perform overexpress role six gene ca convers confirm among sufc hsaa behav better reinforc catalyt enzym activ substrat transmembran transport addit groel endow cell strongest stress toler allevi oxid damag enhanc energi level final optim strain creat coexpress three gene achiev increas pa amount product compar initi valu respect studi expand understand dehydrogen mechan offer effect approach excel steroid transform strain

D039903;D001173;D003348

T007;T121;T109;T125

water mediat interact enhanc alkalin earth cation chelat neighbor caviti cytosin quartet dna quadruplex larger coulomb repuls dival cation compar monoval counterpart dictat cation cation distanc central ion channel quadruplex work densiti function theori continuum solvat model employ studi bond energi alkalin earth cation adjac caviti central ion channel four crystal tetramolecular quadruplex various geometr constraint structur motif avail protein data bank examin order understand cation bind affin could increas aqueous solut cytosin quartet sandwich guanin quartet larger bond energi second alkalin earth cation comparison guanin uracil quartet four high conserv hydrogen bond water molecul center cytosin quartet respons higher electrostat interact cation comparison guanin carbonyl group report find valuabl design synthet quadruplex templat dival cation optoelectron applic

D003596;D054856

T109;T086;T123

target quantit profil gtp bind protein associ metastasi melanoma cell metastasi major obstacl therapeut intervent melanoma sever gtp bind protein found play import role regul cancer metastasi assess systemat regulatori role protein melanoma metastasi employ target chemoproteom method reli applic stabl isotop label desthiobiotin gtp acyl phosphat probe conjunct schedul multipl reaction monitor mrm profil quantit gtp bind protein follow probe label tryptic digest affin pull desthiobiotin conjug peptid differ express level gtp bind protein two match pair primarymetastat melanoma cell line measur use liquid chromatographi mrm analysi also show among top upregul protein metastat melanoma cell ak promot migrat invas melanoma cell overexpress ak primari melanoma cell lead augment migrat invas reciproc knockdown ak metastat melanoma cell result repress invas summari examin relat express level gtp bind protein two pair primarymetastat melanoma cell line result confirm previous report regul melanoma metastasi reveal potenti role ak promot melanoma metastasi

D008545

T191

molgpt molecular generat use transform decod model applic deep learn techniqu de novo generat molecul term invers molecular design gain enorm traction drug design represent molecul smile notat string charact enabl usag state art model natur languag process transform molecular design general inspir generat pre train gpt model shown success generat meaning text train transform decod next token predict task use mask self attent generat druglik molecul studi show model molgpt perform par previous propos modern machin learn framework molecular generat term generat valid uniqu novel molecul furthermor demonstr model train condit control multipl properti generat molecul also show model use generat molecul desir scaffold well desir molecular properti condit generat scaffold smile string desir scaffold properti valu use salienc map highlight interpret generat process model

D015195;D000069550

T090;T066

glycolysi reactiv oxygen speci product particip toxin stimul chicken heterophil extracellular trap toxin kind trichothecen toxin produc fusarium fungi environment pollut endang poultri human health heterophil extracellular trap het form chicken immun defens pathogen infect also involv pathophysiolog mechan sever diseas howev immunotox het format vitro yet report studi heterophil expos dose ngml min observ structur het immunofluoresc stain mechan het format analyz inhibitor picogreen result show trigger het format consist dna elastas cith furthermor increas reactiv oxygen speci ros generat format trigger het also decreas inhibitor glycolysi nicotinamid adenin dinucleotid phosphat nadph oxidas p extracellular signal regul kinas erk signal pathway suggest induc het associ glycolysi ros product erk p signal pathway nadph oxidas taken togeth studi elucid mechan trigger het format may provid new insight understand immunotox earli innat immun chicken

D065206;D013605

T131;T026;T109

enhanc flavan ol biosynthesi saccharomyc cerevisia flavan ol group flavonoid exert benefici effect studi aim enhanc key metabol process relat flavan ol biosynthesi engin saccharomyc cerevisia strain e produc naringenin glucos engin de novo product two basic flavan ol afzelechin afz catechin cat introduct flavonoid hydroxylas flavonoid hydroxylas dihydroflavonol reductas dfr leucoanthocyanidin reductas lar de novo product afz cat achiev combin fa dfr fragaria ananassa vv lar viti vinifera optim ggggs eaaak linker dfr lar prove optim product afz cat respect optim promot enhanc suppli nadph increas product combin best engin strategi optimum strain produc mgl afz mgl cat respect ferment h l bioreactor strategi present could appli effici product flavan ol various microorgan

D002392;D027843

T129;T121;T002;T168;T116;T109

electrochem capillari flow immunoassay detect anti sar cov nucleocapsid protein antibodi point care rapid inexpens serolog test sar cov antibodi need conduct popul level seropreval surveil studi improv diagnost reliabl use combin viral test report novel low cost electrochem capillari flow devic quantifi igg antibodi target sar cov nucleocapsid protein anti n antibodi ngml low volum l human whole blood sampl min sampl prepar need devic integr blood filtrat membran board plasma extract devic made stack layer hydrophil polyest doubl side adhes film creat passiv microfluid circuit autom step enzym link immunosorb assay elisa sampl reagent sequenti deliv nitrocellulos membran modifi recombin sar cov nucleocapsid protein present sampl anti n antibodi captur nitrocellulos membran detect via chronoamperometri perform screen print carbon electrod result quantit electrochem readout result interpret requir make devic ideal point care poc use non train user moreov show devic coupl near field communic potentiostat oper smartphon confirm true poc potenti novelti work resid integr sensit electrochem detect capillari flow immunoassay provid accuraci point care novel electrochem capillari flow devic potenti aid diagnosi infecti diseas point care

D000086382;D000086402

T005;T047;T067

synthesi stabil kinet hydrogen sulfid releas dithiophosph develop chemic slowli releas hydrogen sulfid would aid surviv plant environment stressor well increas harvest yield report seri dialkyldithiophosph disulfidedithiophosph slowli degrad releas hydrogen sulfid presenc water kinet degrad chemic obtain c room temperatur shown ident alkyl sulfid group larg impact rate hydrolysi rate constant vari exampl use tert butanol nucleophil yield dithiophosph hydrolyz faster dithiophosph synthes n butanol indic rate hydrolysi structur depend rate hydrolysi c vari low valu h high valu h hydrogen sulfid releas water also quantifi use hydrogen sulfid sensit electrod corn grown industri scale dose dibutyldithiophosph show dithiophosph potenti applic agricultur load kg per acr increas harvest yield corn observ

D006862

T131;T197;T130

microfluid biosensor rapid nucleic acid quantit base hyperspectr interferometr amplicon complex analysi nucleic acid detect play vital role biomed research clinic medicin temperatur circul chang wide use polymeras chain reaction techniqu time consum technic challeng system develop recombinas polymeras amplif rpa isotherm method rapid nucleic acid detect howev current rpa amplicon detect method complic expens easili generat fals posit restrict promot rpa techniqu work hyperspectr interferometr amplicon complex quantit method present combin asymmetr dipol complex strategi optic scatter analysi gelr dye util form amplicon complex particl fourier domain spectrum comput contribut complex scatter quantit method support microfluid chip automat system develop achiev integr rapid quantit miniscul nucleic acid detect plasmodium falciparum dhfr gene util exampl target nucleic acid quantit singl nucleotid polymorph detect total reaction time decreas mere min limit detect ngl minimum measur concentr target copiesl time sensit turbid detect singl reaction chamber l scatter increas occur templat free control thus fals posit caus primer dimer nonspecif product could avoid experiment result prove provid method system detect singl base mutat dhfr gene reason techniqu rapid automat low cost nucleic acid detect

D015374;D009696

T059;T114;T123;T075

design synthesi mechan antivir acylurea deriv contain trifluoromethylpyridin moieti novel acylurea deriv ab design synthes link activ substructur trifluoromethylpyridin anthranil diamid via acylurea bridg titl compound exhibit good activ tobacco mosaic virus tmv particular compound x ec gml show much higher curat activ ningnanmycin ec gml compound ab show excel inactiv activ ec gml similar ningnanmycin ec gml preliminari mechan deriv investig autodock analysi reveal compound x ab good affin tmv coat protein tmv cp low bind energi kcalmol compar ningnanmycin kcalmol molecular dynam simul show compound x stabl system structur better bind free energi kcalmol ningnanmycin kcalmol microscal thermophoresi show compound x bound strong tmv cp k ningnanmycin k transmiss electron microscopi self assembl experi demonstr compound x ab signific obstruct self assembl tmv rna tmv cp new acylurea deriv excel antivir activ target tmv cp inhibit tmv self assembl consid candid antivir applic

D000998;D014027

T121;T005

distribut urolithin metabotyp healthi chines youth differ gut microbiota predict metabol pathway first studi report distribut urolithin metabotyp um asian peopl specif chines report european latin american three um observ um um b um healthi chines youth rich divers gut microbiota lower um um um b genus level gordonibact um um b signific higher um akkermansia found um correl analysi type content urolithin gut microbiota genus level show genera signific posit correl urolithin genera signific posit associ isourolithin urolithin b addit differ kegg pathway tca cycl energi metabol diseas found gut microbiom three um research need explor mechan metabotyp differenti health benefit ill predisposit three um

D000069196

T007;T001

fragment hit discoveri bind site character indirect affin capillari electrophoresi applic factor xiia fragment base lead discoveri usual strategi drug discoveri identifi innov lead compound success approach strong reli capac detect weak binder character bind site nmr x ray crystallographi convent technolog use tackl challeng howev larg protein consumpt cost equip reduc access affin capillari electrophoresi methodolog develop enabl detect mm binder determin dissoci constant character fragment bind site basi multipl equilibrium theori dissoci constant mm rang determin new methodolog propos establish graphic two fragment bind protein pocket applic methodolog demonstr experiment coagul factor xiia evalu pair fragment expect behavior studi reinforc signific use affin capillari electrophoresi gather valuabl inform medicin chemistri project

D055808;D015956

T116;T062;T126;T123

artifici intellig base portabl bioelectron platform sar cov diagnosi multi nucleotid probe assay clinic decis context recent pandem necess inexpens easili access rapid test kit well understood need stress light report multi nucleotid probe base diagnosi sar cov use bioelectron platform compris low cost chemiresist biochip portabl electron readout android applic data acquisit machin learn base decis make platform perform desir diagnosi standard nasopharyng andor oral swab extract non extract rna sampl without amplifi viral load revers transcript polymeras chain reaction free hybrid assay propos approach offer inexpens fast time result min earli diagnosi oppos exist sar cov diagnosi protocol recommend extract rna sampl assay account test accuraci use heurist approach machin learn base classif method respect case non extract rna sampl decis accuraci achiev use heurist approach machin learn base best fit model produc accuraci furthermor avail handheld readout android applic base simpl user interfac facilit easi access portabl applic besid elimin viral rna extract sampl pre requisit specif detect propos approach present ideal candid point care sar cov diagnosi

D000086382;D000086402

T005;T047;T067

planetari boundari forest nation exceed achiev forest sustain declar sustain develop goal sdg measur safe oper spaceplanetari boundariesof global forest essenti determin global forest pressur manag forest sustain quantifi forestri planetari boundari fpb nation forestri boundari result show fpb billion forest stock increment global timber harvest account fpb timber harvest nation most africa asia exceed nation forestri boundari boundari exceed timber harvest main driven final demand develop nation eg unit state japan emerg economi eg india china global suppli chain studi highlight import fpb global forest manag trade relat policymak find guid global nation forest harvest activ help promot intern cooper mitig global deforest

D003247;D014197

T069;T064;T002;T081;T078

anti osteoclastogen effect indol alkaloid isol barley hordeum vulgar var hexastichon grass part continu program identifi new potenti candid control osteolyt bone diseas natur product alkaloid fraction barley hordeum vulgar var hexastichon grass hva signific inhibit rankl induc osteoclast format protect mice lps induc bone loss phytochem investig hva afford nine indol alkaloid includ one new compound hordeumin eight known analogu four anti osteoclastogen compound four compound signific suppress rankl induc osteoclast format actin ring format bone resorpt concentr depend manner also suppress rankl induc nf b mapk signal pathway activ c fos nfatc compound also reduc express level osteoclast specif marker gene includ trap ctsk dc stamp oscar mmp find suggest hva alkaloid constitu could valuabl candid prevent treatment osteolyt bone diseas

D001862;D001467

T168;T042;T002

collabor low rank matrix approxim assist fast hyperspectr raman imag tip enhanc raman spectroscop imag fast acquisit raman imag essenti accur character analyt inform paper develop collabor low rank matrix approxim method fast hyperspectr raman imag well tip enhanc raman spectroscopi ter imag method combin high signal nois ratio snr data target data perform collabor singular valu decomposit high qualiti refer data impos constraint factor forc compon approxim true signal nois compon simul demonstr method offer state art signal extract perform thus use acceler data acquisit specif result indic clrma larg decreas root mean squar error compar baselin method previous studi appli method fast ter imag aupd bimetal surfac signific decreas integr time spixel time faster convent experi high snr ter spectra clear ter imag well consist scan tunnel microscopi stm imag obtain even weak signal condit appli method fast raman imag hela cell obtain clear raman imag short integr time sline time faster convent experi method offer promis tool ter imag well convent raman imag fast data acquisit requir

D013059

T070;T059

evalu foxo target engag use singl cell microfluid platform cellular thermal shift assay cetsa use extens sinc introduct studi drug target engag within live cell cellular lysat proven use tool earli stage drug discoveri use studi wide rang protein class describ applic singl cell cetsa workflow within microfluid affin captur mac chip enabl us quantit determin activ foxo singl molecul count observ foxo stabil destabil presenc three small molecul inhibitor includ demonstr determin ec success use mac chip singl cell cetsa pave way studi precious clinic sampl owe low number cell need chip also provid use tool studi under popul heterogen exist within cellular system featur usual mask conduct ensembl measur

D055808;D044085

T090;T062

ginsenosid rg allevi aluminum chlorid induc bone impair rat activ tgf smad signal pathway aluminum al induc bone format metabol disord inhibit tgf smad signal pathway one import mechan bone impair ginsenosid rg rg specif biolog effector molecul provid protect bone previous demonstr rg revers aluminum chlorid alcl induc oxid stress metabol disord bone howev whether tgf smad signal pathway involv remain unclear first found rg attenu al induc bone impair vivo vitro reliev structur damag femur increas mct e cell activ differenti miner inhibit cell apoptosi upregul extracellular matrix ecm synthesi express tgf smad signal pathway key factor subsequ signal pathway intervent experi protect effect rg bone impair induc al weaken result indic activ tgf smad signal pathway one mechan rg attenu al induc bone impair

D036145;D053773

T116;T121;T123;T109

angstrom nanomet measur interatom distanc solid state nmr internuclear distanc repres one main structur constraint molecular structur determin use solid state nmr spectroscopi complement chemic shift orient restraint although larg number magic angl spin mas nmr techniqu avail distanc measur tradit c n nmr experi inher limit distanc angstrom due low gyromagnet ratio nuclei recent develop fast mas tripl reson f h nmr probe stimul design mas nmr experi measur distanc nm rang high sensit review describ principl applic multiplex multidimension correl distanc nmr experi emphasi f h base distanc experi repres applic long distanc nmr method biolog macromolecul well small molecul review

D008279;D011506

T170;T060;T123;T059;T116

design polymer thin film direct microbi biofilm growth virul metabol biofilm ubiquit natur yet strategi direct biofilm behavior without genet manipul limit due small select materi use success grow biofilm avail function materi abl support growth program microbi function remain critic bottleneck design deploy function yet safe microb report design insolubl pyridin rich polym surfac synthes use initi chemic vapor deposit led modul biofilm growth virul pseudomona aeruginosa pao varieti extracellular virul factor exhibit decreas product respons function polym signific biomolecul also associ iron acquisit valid materi design strategi report report signifi rich potenti materi base strategi direct behavior natur occur biofilm complement exist genet engin toolkit advanc microbiolog translat medicin biomanufactur

D018441;D011550

T007

mir p inhibit attenu warburg effect stem mainten osteosarcoma cell via inactiv wnt catenin signal microrna mir found overexpress osteosarcoma os aim present studi investig effect mir p warburg effect stem mainten os cell potenti molecular mechan herein mir p overexpress inhibit mg cell via transfect mimic inhibitor effect mir p cell viabil apoptosi warburg effect stem mainten explor os cell result demonstr mir p inhibit suppress mg cell viabil enhanc apoptosi addit mir p inhibit attenu stem mainten mg cell demonstr reduc proport cd posit mg cell decreas tumorspher format capac downregul sox oct nanog protein moreov mir p inhibit suppress warburg effect mg cell indic decreas glucos uptak lactic acid product atp level downregul protein involv warburg effect glut ldha hk pkm furthermor result suggest effect mir p suppress stem warburg effect may associ decreas activ wnt catenin pathway os cell find suggest novel potenti biomark os therapi

D000082802

T039

rare case craniocerv penetr injuri steel bar non missil penetr injuri caus foreign bodi knive sharp wood infrequ report year old male suffer sever craniocerv penetr injuri steel bar success treat surgeri

D006259;D005547;D020197;D014950

T037;T020;T072

anti inflammatori ethosom nanoformul combin iontophoresi chronic wound heal ex vivo studi prescript anti inflammatori drug may consid promis strategi chronic wound heal inflammatori disturb delay heal process seem hydrocortison butyr hb would promis form nano formul enhanc drug deliveri efficaci present studi transderm deliveri nano hb combin iontophoresi investig ex vivo ethosom hb synthesis use lecithin ethanol cholesterol differ ratio hot method negat ethosom hb particl size around nm high stabil day addit evalu entrap effici hb ethosom high perform liquid chromatographi moreov permeat speed amount hb complet thick rat skin presenc absenc iontophoresi show penetr free hb ethosom hb formul zero gcm min respect wherea case appli iontophoresi permeat amount obtain zero gcm min free hb ethosom hb formul respect conclud transderm deliveri ethosom hb effect strategi enhanc drug deliveri improv combin iontophoresi

D007478;D012869

T042;T061

design develop portabl resist sensor base mno gqd nanocomposit trace quantif pb ii water occurr heavi metal ion food chain appear major problem mankind trace heavi metal especi pb ii ion present water bodi remain undetect untreat remain food cycl caus serious health hazard human livestock consumpt pb ii ion may lead serious medic complic includ multipl organ failur fatal convent method heavi metal detect cost time consum requir laboratori space immedi need develop cost effect portabl sens system easili use common man without technic knowhow portabl resist devic miniatur electron develop microfluid well mno gqd nanocomposit sens materi sensit detect pb ii mno gqd nanocomposit easili integr miniatur electron real time field applic propos sensor exhibit tremend potenti integr convent water purif applianc household commerci give indic safeti index drink water develop portabl sensor requir low sampl volum l assess within pb ii concentr rang nm um limit detect lod sensit calcul nm knmmm valid commerci imped analys shelf life portabl sensor found day

D007854;D053761

T131;T073;T196

dioscin load zein nanoparticl allevi lipopolysaccharid induc acut kidney injuri via microrna let signal pathway present studi investig potenti role dioscin dio lipopolysaccharid lps induc kidney injuri purpos dio load zein nanoparticl dio znps formul evalu physicochem paramet dio znps exhibit control releas drug compar free drug suspens result show cell viabil nrk e consist decreas increas lps gml gml compar lps dio induc nps show fold increas cell viabil concentr gml gml gml gml respect dio znps exhibit remark recoveri cell prolifer compar free dio shown cellular morpholog analysi furthermor annexin v stain analysi show lps treat cell possess lowest green fluoresc indic fewer viabl cell wherea dio znps exhibit maximum green fluoresc compar non treat cell indic maximum cell viabil furthermor result show dio znps signific increas express mir let epitheli kidney cell wherea express level tlr signific downregul compar lps treat cell conclus mir let could interest therapeut target nanoparticl base dio could potenti candid manag acut kidney injuri

D058186;D035683;D053758;D015028

T037;T073;T047;T123;T116;T114

control synthesi fluoresc silver nanoparticl differ length oligonucleotid silver nanomateri becom import research topic recent year new type fluoresc materi silver nanomateri appli fluoresc sensor bioimag materi target cancer cell approach oligonucleotid templat control format fluoresc ag nanomateri report experi silver nanoparticl nps synthesis oligonucleotid chain sodium borohydrid nabh silver nitrat agno chang molar ratio dna sodium borohydrid nabh silver nitrat agno fluoresc assay transmiss electron microscopi use characteris silver nps optim select dna chain differ length templat synthesi silver nps found work success develop cap oligonucleotid scaffold silver nanoclust

D053768;D009841

T114;T073

design simul analysi micro electro mechan system microneedl micropump drug deliveri system articl report mechan strength analysi flow characterist squar tip circular tip microneedl employ high potent drug given extrem littl quantiti microlitr use mem technolog prove signific compon micropump applic bio mem microneedl well suitabl mem base micropump drug deliveri system essenti part micropump drug releas patient bodi propos microneedl withstand stress mpa kpa extens investig select materi microneedl carri meet requir biocompat high yield well tensil strength mighti drug vasopressin atropin digoxin administ larg quantiti microneedl design deliv l drug microneedl deliv l array array releas l

D055617

T068;T170

allevi diabet nephropathi zinc oxid nanoparticl streptozotocin induc type diabet rat studi examin effect nanoparticl zinc oxid znonp diabet nephropathi primari caus mortal diabet patient end stage renal diseas diabet adult male rat induc via intraperiton inject streptozotocin znonp intraperiton administ diabet rat daili week diabet associ increas blood glucos level h urinari albumin excret rate glomerular basement membran thick renal oxid stress marker renal mrna protein express transform growth factor fibronectin collagen iv tumour necrosi factor vascular endotheli growth factor moreov express nephrin podocin mrna express matrix metalloproteinas decreas diabet group chang detect control group signific prevent znonp treatment result provid evid znonp amelior renal damag induc diabet rat model nephropathi improv renal function inhibit renal fibrosi oxid stress inflamm abnorm angiogenesi delay develop podocyt injuri present find may help design clinic applic znonp protect develop diabet nephropathi

D003921;D003922;D003928;D053758;D015034

T050;T073;T197;T121;T047

phyto fabric silver nanoparticl induc microbi cell death via reactiv oxygen speci mediat membran damag eco friend synthesi silver nanoparticl agnp number advantag like simplic biocompat low toxic natur physic chemic method present studi author report biosynthes agnp use root extract perenni plant spini gourd momordica dioica investig anti bacteri applic mechanist approach differ biophys techniqu uv vis spectroscopi ftir xrd tem sa dls employ agnp character synthes agnp polydispers crystallin natur anion surfac mv spheric shape averag size nm addit agnp stabl room temperatur differ biolog buffer anti bacteri activ agnp studi respect pathogen bacillus subtili staphylococcus aureus gram posit pseudomona aeruginosa escherichia coli klebsiella planticola gram negat candida albican also mechanist studi agnp protein leakag assay nucleic acid leakag assay atp leakag assay ros accumul determin biofilm degrad activ measur potassium show synthes agnp capabl contain potenti applic antimicrobi therapeut agent pharmaceut industri

D053768;D012834

T073;T196

viscous finger rapid patter techniqu engin cell laden vascular like construct tissu much larger diffus limit distanc rapid provid blood vessel suppli embed cell insid tissu suffici nutrient oxygen regard major strategi success bioengin larg thick tissu construct pattern techniqu viscous finger develop bioengin vascular like tissu within minut control viscos flow rate volum photo cross linkabl prepolym macro microscal vascular network structur precis engin use hele shaw cell design studi cross link vascular like gel finger structur form bottom top base gel creat sandwich like structur cell incorpor finger base gel spread growth direct embed cell success control guid manipul physic properti finger base gel individu moreov finger generat connect surround prepar cell laden microgel base prepolym form prevascular tissu like construct taken togeth cell pattern techniqu extend potenti model fabric larg stackabl vascular tissu like construct ex vivo vivo applic

D023822

T061

valid instrument measur student percept plastin three dimension print anatomi tool due modern medic curriculum technolog advanc anatomi educ evolv beyond cadaver dissect alon plastin techniqu three dimension model print technolog progress gain import howev limit valid reliabl survey evalu student percept new anatomi tool henc studi aim develop valid instrument measur student learn satisfact self efficaci humanist valu perceiv limit plastin print model item survey five point likert scale strong disagre strong agre administ year undergradu medic student follow random control crossov studi evalu plastin print cardiac neck model nineti six respons receiv factor analysi perform kaiser meyer olkin sampl adequaci confirmatori factor analysi yield factor item model good fit latent construct x p root mean squar error approxim root mean squar residu compar fit index tucker lewi index cronbach alpha individu factor rang indic good intern consist demonstr psychometr valid reliabl instrument measur student percept toward plastin print model

D000715;D004504;D000077780;D013337

T065;T059;T097;T091

potent antivir antimicrobi polym safe effect disinfect prevent infect disinfect use effect antimicrobi essenti prevent spread infecti diseas covid pandem brought need effect disinfect greater attent due fast transmiss sar cov current activ ingredi disinfect small molecul microorgan develop resist repeat long term use may penetr skin caus harm side effect end seri membran disrupt polyionen contain quaternari ammonium vari hydrophob compon synthes effect bacteria fungi also fast act clinic isol drug resist strain bacteria formul thicken nonion surfact affect kill effici polyionen also effect prevent infect caus nonenvelop envelop virus effect mous coronavirus ie mous hepat virus mhv depend hydrophob polyionen optim composit inactiv mhv complet import polyionen effect inhibit sar cov within effect microorgan caus damag skin high oral lethal dose overal polyionen promis activ ingredi disinfect prevent viral microbi infect

D000890;D000086382;D004202

T167;T121;T131;T047;T067

sport drug test athlet exposom similar general popul elit athlet expos complex set environment factor includ chemic radiat also biolog physic stressor constitut exposom unlik general popul subject specif scrutini athlet due applic antidop regul associ frequent routin dope control henc investig athlet exposom distinguish deliber drug use differ contamin scenario becom central topic antidop research delic balanc manag vital continu evolv develop sensit analyt techniqu one hand risk athlet exposom potenti caus advers analyt find

D000081413

T058