| Illness,Key Symptoms,Symptoms,Notes,,,, | |
| Adrenal Insufficiency,Fatigue, weakness, abdominal pain, nausea, low blood pressure,Sometimes,Chronic fatigue can be a prominent symptom | |
| Celiac Disease,Digestive problems, bloating, fatigue, skin rash, anemia,Sometimes,Diagnosis requires specific dietary testing. | |
| Crohn's Disease,Abdominal pain, diarrhea, weight loss, fatigue,Sometimes,Can mimic other digestive issues., | |
| Cushing's Syndrome,Weight gain, fatigue, muscle weakness, high blood pressure,Sometimes,Often misdiagnosed due to common symptoms., | |
| Diabetes (Type 2),Increased thirst, frequent urination, fatigue, blurred vision,Sometimes,Early symptoms can be subtle., | |
| Endometriosis,Pelvic pain, heavy periods, infertility,Sometimes,Pain can be chronic and debilitating.,, | |
| Fibromyalgia,Widespread pain, fatigue, sleep disturbances, cognitive difficulties,Yes,Characterized by widespread musculoskeletal pain., | |
| Irritable Bowel Syndrome (IBS),Abdominal pain, bloating, constipation, diarrhea,Sometimes,Symptoms can vary widely., | |
| Lupus,Fatigue, joint pain, skin rash, kidney problems,Sometimes,Can affect multiple organ systems., | |
| Lyme Disease,Fever, headache, fatigue, joint pain, rash (erythema migrans),Sometimes,Early diagnosis is crucial for effective treatment. | |
| Multiple Sclerosis (MS),Fatigue, numbness, tingling, vision problems, muscle weakness,Sometimes,Symptoms can relapse and remit. | |
| Myasthenia Gravis,Muscle weakness, fatigue, drooping eyelids, double vision,Sometimes,Symptoms worsen with activity and improve with rest., | |
| Polycystic Ovary Syndrome (PCOS),Irregular periods, acne, excess hair growth, weight gain,Sometimes,Hormonal imbalances are key., | |
| Rheumatoid Arthritis,Joint pain, swelling, stiffness, fatigue,Yes,Autoimmune disease affecting the joints., | |
| Sarcoidosis,Fatigue, cough, shortness of breath, skin rashes,Sometimes,Can affect multiple organs, especially the lungs. | |
| Sjogren's Syndrome,Dry eyes, dry mouth, fatigue, joint pain,Sometimes,Autoimmune disease affecting exocrine glands., | |
| Thyroid Disorders (Hypothyroidism/Hyperthyroidism),Fatigue, weight changes, mood changes, temperature sensitivity,Sometimes,Can mimic other conditions., | |
| Sleep Apnea,Loud snoring, daytime sleepiness, morning headaches,Sometimes,Diagnosis requires a sleep study.,, | |
| Mast Cell Activation Syndrome (MCAS),Allergic-type reactions, hives, itching, flushing, digestive problems,Sometimes,Difficult to diagnose and often mistaken for allergies. | |
| Small Intestinal Bacterial Overgrowth (SIBO),Bloating, gas, abdominal pain, diarrhea,Sometimes,Diagnosis requires breath testing., | |
| Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS),Pelvic pain, frequent urination, urgency,Sometimes,Chronic pain in the bladder and pelvic region.,, | |
| Complex Regional Pain Syndrome (CRPS),Severe burning pain, swelling, changes in skin color and temperature,Yes,Chronic pain condition often triggered by an injury.,, | |
| Postural Orthostatic Tachycardia Syndrome (POTS),Dizziness, lightheadedness, fainting, rapid heart rate upon standing,Sometimes,Symptoms often worsen with changes in posture., | |
| Ehlers-Danlos Syndromes (EDS),Joint hypermobility, skin hyperextensibility, fragile skin,Sometimes,Genetic connective tissue disorder.,, | |
| Wilson's Disease,Liver problems, neurological symptoms, psychiatric symptoms,Sometimes,Genetic disorder affecting copper metabolism.,, | |
| Autoimmune Hepatitis,Fatigue, jaundice, abdominal pain, liver inflammation,Sometimes,Body attacks its own liver cells., | |
| Primary Biliary Cholangitis (PBC),Fatigue, itching, jaundice, abdominal pain,Sometimes,Autoimmune disease affecting the bile ducts., | |
| Non-alcoholic Fatty Liver Disease (NAFLD),Fatigue, abdominal pain, elevated liver enzymes,Sometimes,Can lead to cirrhosis if left untreated.,, | |
| Hemochromatosis,Fatigue, joint pain, abdominal pain, skin discoloration,Sometimes,Genetic disorder causing iron overload., | |
| Alpha-1 Antitrypsin Deficiency,Shortness of breath, wheezing, chronic cough, liver problems,Sometimes,Genetic disorder affecting the lungs and liver., | |
| Porphyria,Abdominal pain, neurological symptoms, skin sensitivity to light,Sometimes,Group of genetic disorders affecting heme production.,, | |
| Amyloidosis,Fatigue, swelling, numbness, tingling, organ damage,Sometimes,Rare disease characterized by protein deposits in tissues. | |
| Vasculitis,Fatigue, fever, weight loss, rash, organ damage,Sometimes,Inflammation of blood vessels. | |
| Systemic Sclerosis (Scleroderma),Skin thickening, joint pain, Raynaud's phenomenon, organ damage,Sometimes,Connective tissue disorder affecting the skin and internal organs., | |
| Mixed Connective Tissue Disease (MCTD),Symptoms overlapping with lupus, scleroderma, and polymyositis,Sometimes,Autoimmune disease with features of multiple conditions.,, | |
| Polymyositis,Muscle weakness, fatigue, muscle pain,Sometimes,Autoimmune disease causing muscle inflammation.,, | |
| Dermatomyositis,Muscle weakness, skin rash, muscle pain,Sometimes,Autoimmune disease affecting skin and muscles.,, | |
| Giant Cell Arteritis,Headache, jaw pain, vision changes, fever,Sometimes,Inflammation of arteries in the head and neck., | |
| Takayasu Arteritis,Fatigue, fever, weight loss, decreased pulses in the arms and legs,Sometimes,Inflammation of large arteries., | |
| Behcet's Disease,Mouth sores, genital sores, eye inflammation, skin lesions,Sometimes,Chronic inflammatory disorder affecting multiple systems., | |
| IgG4-Related Disease,Masses or swelling in various organs, fatigue, weight loss,Sometimes,Chronic inflammatory condition characterized by IgG4-producing plasma cells.,, | |
| Relapsing Polychondritis,Inflammation of cartilage in various parts of the body, pain, swelling,Sometimes,Rare disease affecting cartilage.,, | |
| Granulomatosis with Polyangiitis (GPA),Respiratory problems, kidney problems, skin lesions,Sometimes,Rare autoimmune disease affecting blood vessels and tissues.,, | |
| Eosinophilic Granulomatosis with Polyangiitis (EGPA),Asthma, sinusitis, nerve damage, skin lesions,Sometimes,Rare autoimmune disease affecting blood vessels and tissues., | |
| Microscopic Polyangiitis (MPA),Kidney problems, skin lesions, nerve damage,Sometimes,Rare autoimmune disease affecting small blood vessels.,, | |
| Primary Sclerosing Cholangitis (PSC),Fatigue, itching, jaundice, abdominal pain,Sometimes,Chronic liver disease affecting the bile ducts., | |
| Idiopathic Pulmonary Fibrosis (IPF),Shortness of breath, dry cough, fatigue,Sometimes,Chronic lung disease causing scarring of lung tissue.,, | |
| Pulmonary Hypertension,Shortness of breath, fatigue, chest pain, dizziness,Sometimes,High blood pressure in the arteries of the lungs., | |