metadata

{}

GoldHamster Model

Model for text classification based on the GoldHamster corpus. Source code is available.

Model Description

Model pre-trained on PubMedBERT and fine-tuned on the GoldHamster corpus.

Language(s) (NLP): English
License: CC BY 3.0 DE
Finetuned from model: https://huggingface.co/microsoft/BiomedNLP-PubMedBERT-base-uncased-abstract

Model Sources [optional]

Repository: https://github.com/mariananeves/goldhamster
Paper: https://europepmc.org/article/ppr/ppr479254

Uses

Model for detecting our eight-label schema: invertebrates, in vivo, human, organs, primary cell lines, immortal cell lines, in silico, others. Predictions are on the document level.

Direct Use

[More Information Needed]

Results

Results are in terms of f-score.

invertebrates	in vivo	human	organs	primary cell lines	immortal cell lines	in silico	others
0.95	0.88	0.86	0.82	0.75	0.83	0.75	0.78

Citation

@misc {PPR:PPR479254,
    Title = {Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments},
    Author = {Neves, Mariana and Klippert, Antonina and Knöspel, Fanny and Rudeck, Juliane and Stolz, Ailine and Ban, Zsofia and Becker, Markus and Diederich, Kai and Grune, Barbara and Kahnau, Pia and Ohnesorge, Nils and Pucher, Johannes and Schönfelder, Gilbert and Bert, Bettina and Butzke, Daniel},
    DOI = {10.21203/rs.3.rs-1526055/v1},
    Abstract = {&lt;h4&gt;Background: &lt;/h4&gt; European Union legislature requires replacement of animal experiments with alternative methods, whenever such methods are suitable to reach the intended scientific objective. However, searching for alternative methods in the scientific literature is a time-consuming task that requires careful screening of an enormously large number of experimental biomedical publications. The identification of potentially relevant methods, e.g. organ or cell culture models, or computer simulations, can be supported with text mining tools specifically built for this purpose. Such tools are trained (or fine tuned) on relevant data sets labeled by human experts. &lt;h4&gt;Methods:&lt;/h4&gt; We developed the GoldHamster corpus, composed of 1,600 PubMed (Medline) abstracts, in which we manually identified the used experimental model according to a set of eight labels, namely: “in vivo”, “organs”, “primary cells”, “immortal cell lines”, “invertebrates”, “humans”, “in silico” and “other” (models). We recruited 13 annotators with expertise in the biomedical domain and assigned each article to two individuals. Three additional rounds of annotation aimed at improving the quality of the annotations with disagreements in the first round. Furthermore, we conducted various machine learning experiments based on supervised learning to evaluate the suitability of the corpus for our classification task. &lt;h4&gt;Results:&lt;/h4&gt; We obtained more than 7,000 abstract-level annotations for the above labels. The inter-annotator agreement (kappa coefficient) varied among labels, and ranged from 0.63 (for “others”) to 0.82 (for “invertebrates”), with an overall score of 0.74. The best-performing machine learning experiment used the BioBERT pre-trained model with fine-tuning to our corpus, which gained an overall f-score of 0.82. &lt;h4&gt;Conclusions:&lt;/h4&gt; We obtained a high agreement for most of the labels, and our evaluation demonstrated, that our corpus is suitable for training reliable predictive models for automatic classification of biomedical literature according to the used experimental models. Our “Smart feature-based interactive” search tool (SMAFIRA) will employ this classifier for supporting the retrieval of alternative methods to animal experiments. The corpus and the source code will be made available.},
    Publisher = {Research Square},
    Year = {2022},
    URL = {https://doi.org/10.21203/rs.3.rs-1526055/v1},
}

Contact

Contact: https://mariananeves.github.io/