README.md

metadata

datasets:
  - allenai/scifact
widget:
  - text: >-
      X-linked genes, particularly those related to chromatin
      structure/remodeling, segregation, and ribosomal biogenesis and
      translational control, may also play key regulatory roles in breast
      carcinogenesis<SEP>While contribution of X chromosome in the
      susceptibility of prostate and ovarian cancer has been demonstrated, the
      role of X-linked genes in breast carcinogenesis is not clearly known. This
      study investigated and compared the X-linked gene expression profiles of
      MMTV-c-myc transgenic mammary tumor (MT) or MMTV-c-myc/MT-tgf-alpha double
      transgenic mouse mammary tumor (DT) to lactating mammary gland. cDNA
      microarray analysis using the Affymetrix system identified 1081 genes
      localized on the X chromosome with 174 and 194 genes at +/-2-fold change
      levels in MT and DT samples, respectively. Differentially expressed
      X-linked genes were predominantly related to chromatin
      structure/remodeling (e.g., Hdac8, Suv39h1, RbAp46 and Adr1), segregation
      (e.g., CENP-I and smc111) and, ribosomal biogenesis and translational
      control (e.g., Dkc1, Rpl44, Rpl39, Eif2s3x, Gspt2 and Rsk4). Confirmation
      of microarray data by semi-quantitative and quantitative RT-PCR in
      selected X-linked genes also showed similar pattern. In addition, the
      expression pattern of two chromosomal regions, XE3 and XF5, suggests that
      XE3 may have escaped from inactivation and XF5 subjected to inactivation.
      In conclusion, our data suggest that X-linked genes may play the key
      regulatory roles in the maintenance of chromatin structure, accurate
      chromosomal segregation and translational control; hence deregulation of
      X-linked genes may promote mammary gland tumorigenesis by promoting
      genetic instability and cell proliferation. Increased understanding of the
      role of X-linked genes and genetic pathways will provide the strategies to
      develop the molecular therapeutics to treat and prevent reproductive
      related cancers.
language:
  - en
metrics:
  - accuracy
  - f1
  - precision
  - recall
tags:
  - medical

Textual Entailment for biomedical texts

Model Description

This model is fine-tuned on SciFact dataset for textual antailment task in the domain of biomedicine.