|
</=,<= |
|
>/=,>= |
|
≤,<= |
|
≥,>= |
|
2nd generation,2nd-generation |
|
5etc times/day,5x/day |
|
Absorption t1/2,t1/2\a |
|
Adverse drug reaction,ADR |
|
Anti-proliferative ,Antiproliferative |
|
Anti-rejection ,Antirejection |
|
Area under curve,AUC |
|
Average concentration,Cavg |
|
Body-weight,Body weight |
|
Broad spectrum,Broad-spectrum |
|
Centi,c |
|
Clearance,Cl |
|
Compared to,cf |
|
Complete response,CR |
|
Composition-of-matter,Composition of matter |
|
Day,day |
|
Days,days |
|
Deci,d |
|
Decilitre,10ml |
|
Dose-limiting toxicities,DLTs |
|
Dose-limiting toxicity,DLT |
|
double blind,double-blind |
|
double masked,double-masked |
|
Drug concentration producing 50% maximum response,EC50 |
|
Drug concentration that reduces response to another drug by 50%,IC50 |
|
early stage,early-stage |
|
Effective dose in 50% patients,ED50 |
|
Elimination t1/2,t1/2\b |
|
Every 10 days,q 10 days |
|
Every 3 weeks,q 3wk |
|
Extended Access,extended-access |
|
Fast track,Fast-track |
|
Fat rich,Fat-rich |
|
For 3 weeks,x3wk |
|
For 5 days,x5 days |
|
Forced Expiratory Volume in 1 sec,FEV1 |
|
Four times a day,qid |
|
Graft versus host,Graft-versus-host |
|
Gram,g |
|
Half-life,t1/2 |
|
Hour,hr |
|
Hours,hr |
|
International units,IU |
|
Intramuscular,im |
|
Intravenous,iv |
|
Kaplan–Meier curves,KM curves |
|
Kilo,k |
|
Kilogram,kg |
|
Litre/dm3,l |
|
Maximum tolerated dose,MTD |
|
Micro,\u |
|
Microgram,\ug |
|
Milli,m |
|
Milligram,mg |
|
Millilitre/cm3,ml |
|
Minute,min |
|
Minutes,min |
|
Moderate to severe,Moderate-to-severe |
|
Molar (NB,Mlar is the same as moles/litre or moles/dm3),M |
|
Mole,mol |
|
Month,mth |
|
Months,mth |
|
Nano,n |
|
Nanogram,ng |
|
Netherlands,The Netherlands |
|
Non Randomized,non-randomized |
|
Once daily,once-daily |
|
Once weekly,1x/wk |
|
Open label,open-label |
|
Oral,po |
|
Orally,po |
|
Overall survival,OS |
|
Parallel Assignment,parallel-assignment |
|
Peak plasma conc.,Cmax |
|
per day,/day |
|
Pico,p |
|
Picogram,pg |
|
Placebo-controlled,placebo-controlled |
|
Progression-free survival,PFS |
|
Proof of concept,proof-of-concept |
|
pts,patients |
|
Quarter,qtr |
|
Randomized,randomized |
|
Second half of 2017,2nd half of 2017 |
|
Second,s |
|
Seconds,s |
|
Side effects,side-effects |
|
Single Group,single-group |
|
ß,beta |
|
Stable disease,SD |
|
Subcutaneous,sc |
|
TEAEs,treatment-emergent adverse events |
|
Three times a day,tid |
|
Three times a week,3x/wk |
|
Time to disease,Time-to-disease |
|
Time to disease progression,Time-to-disease progression |
|
Time to from admin. to Cmax,Tmax |
|
Twice daily,bid |
|
Twice per week,2x/wk |
|
United Kingdom,The UK |
|
United States,The US |
|
Units,U |
|
Versus,vs |
|
Volume of distribution,Vd |
|
Week,wk |
|
Weeks,wk |
|
Well-tolerated,Well tolerated |
|
Year,yr |
|
Years,yr |
|
α,alpha |
|
γ,gamma |
|
δ,delta |
|
σ,sigma |
|
participants,subjects |
|
The purpose of this study is, |
|
The purpose of this study was, |
|
The purpose of the study is, |
|
The main aim of the study is, |
|
The objective of the trial is, |
|
The objective of the study is, |
|
to find out,to evaluate |
|
to demonstrate,to demonstrate |
|
to see,to assess |
|
to compare,to compare |
|
to evaluate,to evaluate |
|
to determine,to determine |
|
to investigate,to investigate |
|
study of, to evaluate |
|
phase 1,Phase I |
|
phase 2,Phase II |
|
phase 3,Phase III |
|
phase 1/2,Phase I/II |
|
phase 2/3,Phase II/III |
|
phase i,Phase I |
|
phase ii,Phase II |
|
phase iii,Phase III |
|
one,1 |
|
two,2 |
|
three,3 |
|
four,4 |
|
five,5 |
|
six,6 |
|
seven,7 |
|
eight,8 |
|
nine,9 |
|
eleven,11 |
|
|,/ |
|
Placebo comparator,Placebo-controlled |
|
Placebo controlled,Placebo-controlled |
|
placebo control,Placebo-controlled |
|
active comparator,active-controlled |
|
open label,open-label |
|
4-week,4 wk |
|
3-Week,3 wk |
|
British Approved Name,BAN |
|
International Nonproprietary Name,INN |
|
US Approved Name,USAN |
|
Acute myelogenous leukaemia,AML |
|
Acquired immune deficiency syndrome,AIDS |
|
Blood pressure,BP |
|
Chronic myelogenous leukaemia,CML |
|
Chronic Obstructive Pulmonary Disease,COPD |
|
Complete response,CR |
|
Deep vein thrombosis,DVT |
|
Forced Expiratory Volume in 1 sec,FEV1 |
|
Graft Versus Host disease,GvHD |
|
Heart rate,HR |
|
Hepatitis B/C virus,HBV/HCV |
|
Herpes simplex virus,HSV |
|
Highly active antiretroviral therapy,HAART |
|
Human immunodeficiency virus,HIV |
|
Inflammatory bowel disease,IBD |
|
Irritable bowel syndrome,IBS |
|
Multiple sclerosis,MS |
|
Myocardial infarction,MI |
|
Non-steroidal anti-inflammatory drug,NSAID |
|
Osteoarthritis,OA |
|
Partial response,PR |
|
Rheumatoid arthritis,RA |
|
Severe combined immunodeficiency,SCID |
|
Simian immunodeficiency virus,SIV |
|
Stable disease,SD |
|
Systemic lupus erythramatosus,SLE |
|
Biological Licence Application,BLA |
|
Co-operative research and development agreement,CRADA |
|
European Medicine Evaluation Agency,EMEA |
|
European Union's Committee for Proprietary Medicinal Products,CPMP |
|
Food and Drug Administration,FDA |
|
Investigational New Drug,IND |
|
Intellectual Property,IP |
|
Marketing Authorization Approval,MAA |
|
Medicine Control Agency,MCA |
|
New Drug Application,NDA |
|
Prescription Drug User Fee Act,PDUFA |
|
tumor,tumour |
|
tumors,tumours |
|
leukemia,leukaemia |
|
hematological,haematological |
|
alzheimer's disease,Alzheimer's disease |
|
egfr,EGFR |
|
EGFR,EGFR |
|
gilead,GILEAD |