| { |
| "warfarin": { |
| "aspirin": { |
| "severity": "high", |
| "description": "Increased risk of bleeding when combined", |
| "recommendation": "Monitor INR closely; consider alternative pain relief" |
| }, |
| "ibuprofen": { |
| "severity": "high", |
| "description": "Increased risk of gastrointestinal bleeding", |
| "recommendation": "Avoid combination; use acetaminophen instead" |
| }, |
| "naproxen": { |
| "severity": "high", |
| "description": "Increased anticoagulant effect and bleeding risk", |
| "recommendation": "Avoid NSAIDs with warfarin" |
| }, |
| "vitamin k": { |
| "severity": "moderate", |
| "description": "Vitamin K can reduce warfarin effectiveness", |
| "recommendation": "Maintain consistent vitamin K intake" |
| } |
| }, |
| "metformin": { |
| "alcohol": { |
| "severity": "high", |
| "description": "Increased risk of lactic acidosis", |
| "recommendation": "Limit alcohol consumption" |
| }, |
| "contrast dye": { |
| "severity": "high", |
| "description": "Risk of contrast-induced nephropathy and lactic acidosis", |
| "recommendation": "Hold metformin before and after contrast procedures" |
| } |
| }, |
| "simvastatin": { |
| "grapefruit": { |
| "severity": "moderate", |
| "description": "Grapefruit increases simvastatin levels, risk of muscle damage", |
| "recommendation": "Avoid grapefruit and grapefruit juice" |
| }, |
| "erythromycin": { |
| "severity": "high", |
| "description": "Increased risk of rhabdomyolysis", |
| "recommendation": "Use alternative antibiotic or statin" |
| }, |
| "amiodarone": { |
| "severity": "high", |
| "description": "Increased risk of myopathy", |
| "recommendation": "Limit simvastatin dose to 20mg daily" |
| } |
| }, |
| "lisinopril": { |
| "potassium": { |
| "severity": "moderate", |
| "description": "Risk of hyperkalemia (high potassium)", |
| "recommendation": "Monitor potassium levels regularly" |
| }, |
| "spironolactone": { |
| "severity": "high", |
| "description": "Significant risk of hyperkalemia", |
| "recommendation": "Monitor potassium; use with caution" |
| }, |
| "nsaids": { |
| "severity": "moderate", |
| "description": "May reduce antihypertensive effect and worsen kidney function", |
| "recommendation": "Use lowest effective NSAID dose for shortest duration" |
| } |
| }, |
| "digoxin": { |
| "amiodarone": { |
| "severity": "high", |
| "description": "Amiodarone increases digoxin levels significantly", |
| "recommendation": "Reduce digoxin dose by 50%; monitor levels" |
| }, |
| "verapamil": { |
| "severity": "high", |
| "description": "Increased digoxin levels and risk of heart block", |
| "recommendation": "Reduce digoxin dose; monitor ECG" |
| }, |
| "quinidine": { |
| "severity": "high", |
| "description": "Doubles digoxin levels", |
| "recommendation": "Reduce digoxin dose by 50%" |
| } |
| }, |
| "clopidogrel": { |
| "omeprazole": { |
| "severity": "moderate", |
| "description": "Omeprazole may reduce clopidogrel effectiveness", |
| "recommendation": "Consider pantoprazole as alternative PPI" |
| }, |
| "aspirin": { |
| "severity": "moderate", |
| "description": "Increased bleeding risk but often used together therapeutically", |
| "recommendation": "Monitor for signs of bleeding" |
| } |
| }, |
| "methotrexate": { |
| "nsaids": { |
| "severity": "high", |
| "description": "NSAIDs increase methotrexate toxicity", |
| "recommendation": "Avoid NSAIDs or use with extreme caution" |
| }, |
| "trimethoprim": { |
| "severity": "high", |
| "description": "Increased risk of bone marrow suppression", |
| "recommendation": "Avoid combination; monitor blood counts" |
| }, |
| "penicillin": { |
| "severity": "moderate", |
| "description": "May increase methotrexate levels", |
| "recommendation": "Monitor for methotrexate toxicity" |
| } |
| }, |
| "lithium": { |
| "nsaids": { |
| "severity": "high", |
| "description": "NSAIDs increase lithium levels significantly", |
| "recommendation": "Avoid NSAIDs; monitor lithium levels if used" |
| }, |
| "ace inhibitors": { |
| "severity": "high", |
| "description": "ACE inhibitors increase lithium levels", |
| "recommendation": "Monitor lithium levels closely" |
| }, |
| "diuretics": { |
| "severity": "high", |
| "description": "Thiazide diuretics increase lithium levels", |
| "recommendation": "Avoid thiazides; monitor lithium if used" |
| } |
| }, |
| "doxorubicin": { |
| "trastuzumab": { |
| "severity": "high", |
| "description": "Increased risk of cardiotoxicity", |
| "recommendation": "Monitor cardiac function; space administration" |
| }, |
| "cyclophosphamide": { |
| "severity": "moderate", |
| "description": "Additive cardiotoxicity risk", |
| "recommendation": "Monitor cardiac function" |
| }, |
| "paclitaxel": { |
| "severity": "moderate", |
| "description": "Altered doxorubicin metabolism", |
| "recommendation": "Give doxorubicin before paclitaxel" |
| } |
| }, |
| "fluoxetine": { |
| "maois": { |
| "severity": "critical", |
| "description": "Risk of serotonin syndrome - potentially fatal", |
| "recommendation": "Contraindicated; allow 5-week washout" |
| }, |
| "tramadol": { |
| "severity": "high", |
| "description": "Increased risk of serotonin syndrome and seizures", |
| "recommendation": "Avoid combination if possible" |
| }, |
| "triptans": { |
| "severity": "moderate", |
| "description": "Possible serotonin syndrome", |
| "recommendation": "Use with caution; monitor for symptoms" |
| } |
| }, |
| "ciprofloxacin": { |
| "theophylline": { |
| "severity": "high", |
| "description": "Ciprofloxacin increases theophylline levels significantly", |
| "recommendation": "Reduce theophylline dose by 50%; monitor levels" |
| }, |
| "tizanidine": { |
| "severity": "critical", |
| "description": "Dramatic increase in tizanidine levels - contraindicated", |
| "recommendation": "Do not use together" |
| }, |
| "antacids": { |
| "severity": "moderate", |
| "description": "Antacids reduce ciprofloxacin absorption", |
| "recommendation": "Take ciprofloxacin 2h before or 6h after antacids" |
| } |
| }, |
|
|
| "aspirin": {}, |
| "ibuprofen": {}, |
| "naproxen": {}, |
| "acetaminophen": {}, |
| "paracetamol": {}, |
| "diclofenac": {}, |
| "celecoxib": {}, |
| "indomethacin": {}, |
| "ketorolac": {}, |
| "meloxicam": {}, |
| "tramadol": {}, |
| "codeine": {}, |
| "morphine": {}, |
| "oxycodone": {}, |
| "hydrocodone": {}, |
| "fentanyl": {}, |
| "buprenorphine": {}, |
| "naloxone": {}, |
| "naltrexone": {}, |
| "amoxicillin": {}, |
| "ampicillin": {}, |
| "penicillin": {}, |
| "piperacillin": {}, |
| "tazobactam": {}, |
| "levofloxacin": {}, |
| "moxifloxacin": {}, |
| "erythromycin": {}, |
| "azithromycin": {}, |
| "clarithromycin": {}, |
| "tetracycline": {}, |
| "doxycycline": {}, |
| "minocycline": {}, |
| "trimethoprim": {}, |
| "sulfamethoxazole": {}, |
| "metronidazole": {}, |
| "clindamycin": {}, |
| "vancomycin": {}, |
| "gentamicin": {}, |
| "amikacin": {}, |
| "ceftriaxone": {}, |
| "cefazolin": {}, |
| "cephalexin": {}, |
| "meropenem": {}, |
| "imipenem": {}, |
| "linezolid": {}, |
| "rifampicin": {}, |
| "rifampin": {}, |
| "isoniazid": {}, |
| "ethambutol": {}, |
| "pyrazinamide": {}, |
| "ticagrelor": {}, |
| "apixaban": {}, |
| "rivaroxaban": {}, |
| "dabigatran": {}, |
| "heparin": {}, |
| "enoxaparin": {}, |
| "enalapril": {}, |
| "ramipril": {}, |
| "captopril": {}, |
| "perindopril": {}, |
| "losartan": {}, |
| "valsartan": {}, |
| "irbesartan": {}, |
| "candesartan": {}, |
| "telmisartan": {}, |
| "olmesartan": {}, |
| "amlodipine": {}, |
| "nifedipine": {}, |
| "diltiazem": {}, |
| "verapamil": {}, |
| "atenolol": {}, |
| "metoprolol": {}, |
| "carvedilol": {}, |
| "bisoprolol": {}, |
| "propranolol": {}, |
| "nebivolol": {}, |
| "labetalol": {}, |
| "spironolactone": {}, |
| "furosemide": {}, |
| "frusemide": {}, |
| "hydrochlorothiazide": {}, |
| "indapamide": {}, |
| "chlorthalidone": {}, |
| "amiodarone": {}, |
| "atorvastatin": {}, |
| "rosuvastatin": {}, |
| "pravastatin": {}, |
| "fluvastatin": {}, |
| "ezetimibe": {}, |
| "fenofibrate": {}, |
| "gemfibrozil": {}, |
| "nitroglycerin": {}, |
| "glyceryl trinitrate": {}, |
| "isosorbide": {}, |
| "hydralazine": {}, |
| "glibenclamide": {}, |
| "glipizide": {}, |
| "gliclazide": {}, |
| "glimepiride": {}, |
| "insulin": {}, |
| "insulin glargine": {}, |
| "insulin aspart": {}, |
| "insulin lispro": {}, |
| "insulin detemir": {}, |
| "sitagliptin": {}, |
| "saxagliptin": {}, |
| "alogliptin": {}, |
| "linagliptin": {}, |
| "empagliflozin": {}, |
| "dapagliflozin": {}, |
| "canagliflozin": {}, |
| "pioglitazone": {}, |
| "rosiglitazone": {}, |
| "exenatide": {}, |
| "liraglutide": {}, |
| "dulaglutide": {}, |
| "semaglutide": {}, |
| "acarbose": {}, |
| "salbutamol": {}, |
| "albuterol": {}, |
| "salmeterol": {}, |
| "formoterol": {}, |
| "budesonide": {}, |
| "beclomethasone": {}, |
| "fluticasone": {}, |
| "tiotropium": {}, |
| "ipratropium": {}, |
| "montelukast": {}, |
| "theophylline": {}, |
| "aminophylline": {}, |
| "prednisolone": {}, |
| "prednisone": {}, |
| "dexamethasone": {}, |
| "betamethasone": {}, |
| "hydrocortisone": {}, |
| "methylprednisolone": {}, |
| "sertraline": {}, |
| "paroxetine": {}, |
| "citalopram": {}, |
| "escitalopram": {}, |
| "venlafaxine": {}, |
| "duloxetine": {}, |
| "mirtazapine": {}, |
| "amitriptyline": {}, |
| "nortriptyline": {}, |
| "imipramine": {}, |
| "clomipramine": {}, |
| "haloperidol": {}, |
| "risperidone": {}, |
| "olanzapine": {}, |
| "quetiapine": {}, |
| "aripiprazole": {}, |
| "clozapine": {}, |
| "ziprasidone": {}, |
| "paliperidone": {}, |
| "valproate": {}, |
| "valproic acid": {}, |
| "carbamazepine": {}, |
| "lamotrigine": {}, |
| "phenytoin": {}, |
| "phenobarbitone": {}, |
| "phenobarbital": {}, |
| "levetiracetam": {}, |
| "topiramate": {}, |
| "gabapentin": {}, |
| "pregabalin": {}, |
| "diazepam": {}, |
| "lorazepam": {}, |
| "alprazolam": {}, |
| "clonazepam": {}, |
| "midazolam": {}, |
| "zolpidem": {}, |
| "zopiclone": {}, |
| "methylphenidate": {}, |
| "atomoxetine": {}, |
| "donepezil": {}, |
| "memantine": {}, |
| "rivastigmine": {}, |
| "galantamine": {}, |
| "omeprazole": {}, |
| "pantoprazole": {}, |
| "lansoprazole": {}, |
| "esomeprazole": {}, |
| "rabeprazole": {}, |
| "ranitidine": {}, |
| "famotidine": {}, |
| "cimetidine": {}, |
| "metoclopramide": {}, |
| "domperidone": {}, |
| "ondansetron": {}, |
| "granisetron": {}, |
| "loperamide": {}, |
| "mesalazine": {}, |
| "sulfasalazine": {}, |
| "azathioprine": {}, |
| "levothyroxine": {}, |
| "thyroxine": {}, |
| "carbimazole": {}, |
| "propylthiouracil": {}, |
| "fludrocortisone": {}, |
| "testosterone": {}, |
| "estradiol": {}, |
| "progesterone": {}, |
| "medroxyprogesterone": {}, |
| "norethisterone": {}, |
| "ethinylestradiol": {}, |
| "tamoxifen": {}, |
| "letrozole": {}, |
| "anastrozole": {}, |
| "exemestane": {}, |
| "cyclophosphamide": {}, |
| "vincristine": {}, |
| "paclitaxel": {}, |
| "docetaxel": {}, |
| "cisplatin": {}, |
| "carboplatin": {}, |
| "fluorouracil": {}, |
| "capecitabine": {}, |
| "imatinib": {}, |
| "erlotinib": {}, |
| "trastuzumab": {}, |
| "rituximab": {}, |
| "bevacizumab": {}, |
| "cyclosporine": {}, |
| "cyclosporin": {}, |
| "tacrolimus": {}, |
| "mycophenolate": {}, |
| "hydroxychloroquine": {}, |
| "chloroquine": {}, |
| "allopurinol": {}, |
| "colchicine": {}, |
| "alendronate": {}, |
| "risedronate": {}, |
| "zoledronic acid": {}, |
| "calcium carbonate": {}, |
| "vitamin d": {}, |
| "cholecalciferol": {}, |
| "ferrous sulphate": {}, |
| "ferrous sulfate": {}, |
| "folic acid": {}, |
| "cyanocobalamin": {}, |
| "vitamin b12": {}, |
| "zinc sulfate": {}, |
| "magnesium": {}, |
| "potassium chloride": {}, |
| "sodium chloride": {}, |
| "albumin": {}, |
| "dextrose": {}, |
| "amoxicillin-clavulanate": {}, |
| "co-amoxiclav": {}, |
| "clavulanic acid": {}, |
| "fluconazole": {}, |
| "itraconazole": {}, |
| "voriconazole": {}, |
| "acyclovir": {}, |
| "aciclovir": {}, |
| "valacyclovir": {}, |
| "oseltamivir": {}, |
| "tenofovir": {}, |
| "emtricitabine": {}, |
| "lamivudine": {}, |
| "efavirenz": {}, |
| "lopinavir": {}, |
| "ritonavir": {}, |
| "atazanavir": {}, |
| "dolutegravir": {}, |
| "quinidine": {} |
| } |
|
|
