Spaces:
Running
Running
Delete utils/api_clients.py
Browse files- utils/api_clients.py +0 -194
utils/api_clients.py
DELETED
|
@@ -1,194 +0,0 @@
|
|
| 1 |
-
"""
|
| 2 |
-
utils/api_clients.py
|
| 3 |
-
------------------------------------------------
|
| 4 |
-
Enhanced API clients for:
|
| 5 |
-
- PubMed (NCBI)
|
| 6 |
-
- ClinicalTrials.gov
|
| 7 |
-
- FDA Open Data
|
| 8 |
-
- WHO ICTRP
|
| 9 |
-
------------------------------------------------
|
| 10 |
-
Optimized for hybrid VAN-based query processing:
|
| 11 |
-
- Automatically truncates long queries (top keywords only)
|
| 12 |
-
- Resilient to API downtime or malformed responses
|
| 13 |
-
- HTML formatted results for Gradio rendering
|
| 14 |
-
"""
|
| 15 |
-
|
| 16 |
-
import requests
|
| 17 |
-
import html
|
| 18 |
-
import re
|
| 19 |
-
import traceback
|
| 20 |
-
|
| 21 |
-
# ============================================================
|
| 22 |
-
# 🔹 Query Normalization
|
| 23 |
-
# ============================================================
|
| 24 |
-
def _normalize_query(query: str, max_words: int = 5) -> str:
|
| 25 |
-
"""
|
| 26 |
-
Cleans and shortens user query for API compatibility.
|
| 27 |
-
Removes filler phrases and limits to key words.
|
| 28 |
-
"""
|
| 29 |
-
q = query.lower()
|
| 30 |
-
q = re.sub(
|
| 31 |
-
r"(what is|define|explain|describe|in clinical trials|the meaning of|tell me about|explanation of|concept of)\b",
|
| 32 |
-
"",
|
| 33 |
-
q,
|
| 34 |
-
)
|
| 35 |
-
q = re.sub(r"[^a-z0-9\s]", "", q)
|
| 36 |
-
q = re.sub(r"\s+", " ", q).strip()
|
| 37 |
-
|
| 38 |
-
# limit to first few words (avoid 404s from overlong queries)
|
| 39 |
-
words = q.split()
|
| 40 |
-
q = " ".join(words[:max_words])
|
| 41 |
-
return q or "clinical trial"
|
| 42 |
-
|
| 43 |
-
# ============================================================
|
| 44 |
-
# 🔹 PubMed API (NCBI E-Utilities)
|
| 45 |
-
# ============================================================
|
| 46 |
-
def fetch_pubmed(query: str, limit: int = 3) -> str:
|
| 47 |
-
try:
|
| 48 |
-
q = _normalize_query(query)
|
| 49 |
-
base = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/"
|
| 50 |
-
esearch = f"{base}esearch.fcgi?db=pubmed&term={q}&retmax={limit}&retmode=json"
|
| 51 |
-
res = requests.get(esearch, timeout=10)
|
| 52 |
-
res.raise_for_status()
|
| 53 |
-
|
| 54 |
-
ids = res.json().get("esearchresult", {}).get("idlist", [])
|
| 55 |
-
if not ids:
|
| 56 |
-
return f"<i>No PubMed results found for <b>{html.escape(q)}</b>.</i>"
|
| 57 |
-
|
| 58 |
-
summaries = []
|
| 59 |
-
for pmid in ids:
|
| 60 |
-
summary_url = f"{base}esummary.fcgi?db=pubmed&id={pmid}&retmode=json"
|
| 61 |
-
sres = requests.get(summary_url, timeout=10)
|
| 62 |
-
sres.raise_for_status()
|
| 63 |
-
doc = sres.json()["result"].get(pmid, {})
|
| 64 |
-
title = html.escape(doc.get("title", "Untitled"))
|
| 65 |
-
source = html.escape(doc.get("source", ""))
|
| 66 |
-
pubdate = html.escape(doc.get("pubdate", ""))
|
| 67 |
-
link = f"https://pubmed.ncbi.nlm.nih.gov/{pmid}/"
|
| 68 |
-
summaries.append(
|
| 69 |
-
f"<b>{title}</b><br>{source} ({pubdate})<br>"
|
| 70 |
-
f"<a href='{link}' target='_blank'>[PubMed]</a>"
|
| 71 |
-
)
|
| 72 |
-
|
| 73 |
-
return "<br><br>".join(summaries)
|
| 74 |
-
|
| 75 |
-
except Exception as e:
|
| 76 |
-
traceback.print_exc()
|
| 77 |
-
return f"<i>PubMed fetch failed for <b>{html.escape(query)}</b>: {e}</i>"
|
| 78 |
-
|
| 79 |
-
# ============================================================
|
| 80 |
-
# 🔹 ClinicalTrials.gov API
|
| 81 |
-
# ============================================================
|
| 82 |
-
def fetch_clinicaltrials(query: str, limit: int = 3) -> str:
|
| 83 |
-
"""
|
| 84 |
-
Retrieves brief summaries of matching trials from ClinicalTrials.gov.
|
| 85 |
-
Automatically truncates query to avoid 404s on long input.
|
| 86 |
-
"""
|
| 87 |
-
try:
|
| 88 |
-
q = _normalize_query(query)
|
| 89 |
-
url = (
|
| 90 |
-
f"https://clinicaltrials.gov/api/query/study_fields?"
|
| 91 |
-
f"expr={q}&fields=NCTId,BriefTitle,Condition,OverallStatus"
|
| 92 |
-
f"&max_rnk={limit}&fmt=json"
|
| 93 |
-
)
|
| 94 |
-
res = requests.get(url, timeout=10)
|
| 95 |
-
res.raise_for_status()
|
| 96 |
-
|
| 97 |
-
studies = res.json().get("StudyFieldsResponse", {}).get("StudyFields", [])
|
| 98 |
-
if not studies:
|
| 99 |
-
return f"<i>No trials found for <b>{html.escape(q)}</b>.</i>"
|
| 100 |
-
|
| 101 |
-
formatted = []
|
| 102 |
-
for s in studies:
|
| 103 |
-
nct = s.get("NCTId", [""])[0]
|
| 104 |
-
title = html.escape(s.get("BriefTitle", [""])[0])
|
| 105 |
-
condition = html.escape(", ".join(s.get("Condition", [])))
|
| 106 |
-
status = html.escape(s.get("OverallStatus", ["Unknown"])[0])
|
| 107 |
-
link = f"https://clinicaltrials.gov/study/{nct}" if nct else "#"
|
| 108 |
-
formatted.append(
|
| 109 |
-
f"<b>{title}</b><br>"
|
| 110 |
-
f"Condition: {condition or 'N/A'}<br>"
|
| 111 |
-
f"Status: {status}<br>"
|
| 112 |
-
f"<a href='{link}' target='_blank'>[ClinicalTrials.gov]</a>"
|
| 113 |
-
)
|
| 114 |
-
|
| 115 |
-
return "<br><br>".join(formatted)
|
| 116 |
-
|
| 117 |
-
except Exception as e:
|
| 118 |
-
traceback.print_exc()
|
| 119 |
-
return f"<i>ClinicalTrials.gov fetch failed for <b>{html.escape(query)}</b>: {e}</i>"
|
| 120 |
-
|
| 121 |
-
# ============================================================
|
| 122 |
-
# 🔹 FDA Open Data API
|
| 123 |
-
# ============================================================
|
| 124 |
-
def fetch_fda(query: str, limit: int = 3) -> str:
|
| 125 |
-
"""
|
| 126 |
-
Retrieves FDA label and safety data for a given compound/drug name.
|
| 127 |
-
"""
|
| 128 |
-
try:
|
| 129 |
-
q = _normalize_query(query)
|
| 130 |
-
url = f"https://api.fda.gov/drug/label.json?search=openfda.brand_name:{q}&limit={limit}"
|
| 131 |
-
res = requests.get(url, timeout=10)
|
| 132 |
-
|
| 133 |
-
if res.status_code == 404:
|
| 134 |
-
return f"<i>No FDA data found for <b>{html.escape(q)}</b>.</i>"
|
| 135 |
-
|
| 136 |
-
res.raise_for_status()
|
| 137 |
-
data = res.json().get("results", [])
|
| 138 |
-
if not data:
|
| 139 |
-
return f"<i>No FDA label results found for <b>{html.escape(q)}</b>.</i>"
|
| 140 |
-
|
| 141 |
-
formatted = []
|
| 142 |
-
for entry in data:
|
| 143 |
-
brand = ", ".join(entry.get("openfda", {}).get("brand_name", []))
|
| 144 |
-
generic = ", ".join(entry.get("openfda", {}).get("generic_name", []))
|
| 145 |
-
purpose = html.escape(" ".join(entry.get("purpose", [])[:1]))
|
| 146 |
-
warnings = html.escape(" ".join(entry.get("warnings", [])[:1]))
|
| 147 |
-
link = "https://open.fda.gov/drug/label/"
|
| 148 |
-
formatted.append(
|
| 149 |
-
f"<b>{brand or q}</b> ({generic or 'N/A'})<br>"
|
| 150 |
-
f"<u>Purpose:</u> {purpose or 'N/A'}<br>"
|
| 151 |
-
f"<u>Warning:</u> {warnings or 'N/A'}<br>"
|
| 152 |
-
f"<a href='{link}' target='_blank'>[FDA Label]</a>"
|
| 153 |
-
)
|
| 154 |
-
|
| 155 |
-
return "<br><br>".join(formatted)
|
| 156 |
-
|
| 157 |
-
except Exception as e:
|
| 158 |
-
traceback.print_exc()
|
| 159 |
-
return f"<i>FDA fetch failed for <b>{html.escape(query)}</b>: {e}</i>"
|
| 160 |
-
|
| 161 |
-
# ============================================================
|
| 162 |
-
# 🔹 WHO ICTRP (Backup Trial Source)
|
| 163 |
-
# ============================================================
|
| 164 |
-
def fetch_who_trials(query: str, limit: int = 2) -> str:
|
| 165 |
-
"""
|
| 166 |
-
Optional backup trial search from WHO ICTRP API.
|
| 167 |
-
Returns simplified summaries for readability.
|
| 168 |
-
"""
|
| 169 |
-
try:
|
| 170 |
-
q = _normalize_query(query)
|
| 171 |
-
url = f"https://trialsearch.who.int/api/TrialSearch?query={q}"
|
| 172 |
-
res = requests.get(url, timeout=10)
|
| 173 |
-
|
| 174 |
-
if res.status_code != 200:
|
| 175 |
-
return "<i>WHO ICTRP API unavailable or throttled.</i>"
|
| 176 |
-
|
| 177 |
-
trials = res.json().get("TrialSearchResult", [])
|
| 178 |
-
if not trials:
|
| 179 |
-
return f"<i>No WHO trials found for <b>{html.escape(q)}</b>.</i>"
|
| 180 |
-
|
| 181 |
-
formatted = []
|
| 182 |
-
for t in trials[:limit]:
|
| 183 |
-
title = html.escape(t.get("Scientific_title", "Untitled"))
|
| 184 |
-
registry = html.escape(t.get("Register", ""))
|
| 185 |
-
country = html.escape(t.get("Recruitment_Country", ""))
|
| 186 |
-
formatted.append(
|
| 187 |
-
f"<b>{title}</b><br>{registry or 'Registry Unknown'} — {country or 'N/A'}"
|
| 188 |
-
)
|
| 189 |
-
|
| 190 |
-
return "<br><br>".join(formatted)
|
| 191 |
-
|
| 192 |
-
except Exception as e:
|
| 193 |
-
traceback.print_exc()
|
| 194 |
-
return f"<i>WHO ICTRP fetch failed for <b>{html.escape(query)}</b>: {e}</i>"
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|