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NSQIP-ST / app.py

mertkarabacak

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	import os
	HF_TOKEN = os.getenv("HF_TOKEN")

	import numpy as np
	import pandas as pd

	import sklearn
	import sklearn.metrics
	from sklearn.metrics import roc_auc_score, roc_curve, precision_recall_curve, auc, precision_score, recall_score, f1_score, classification_report, accuracy_score, confusion_matrix, ConfusionMatrixDisplay, matthews_corrcoef
	from sklearn.model_selection import train_test_split
	from sklearn.calibration import calibration_curve

	from scipy import stats as st
	from random import randrange
	from matplotlib import pyplot as plt
	from scipy.special import softmax

	import xgboost as xgb
	import lightgbm as lgb
	import catboost as cb
	from catboost import Pool
	from sklearn.ensemble import RandomForestClassifier


	import optuna

	import shap

	import gradio as gr

	import random

	#Read and redefine data.

	from datasets import load_dataset
	data = load_dataset("mertkarabacak/NSQIP-ST", data_files="st_cpt_only_imputed.csv", use_auth_token = HF_TOKEN)

	data = pd.DataFrame(data['train'])

	variables = ['SEX', 'TRANST', 'AGE', 'SURGSPEC', 'HEIGHT', 'WEIGHT', 'DIABETES', 'SMOKE', 'DYSPNEA', 'FNSTATUS2', 'HXCOPD', 'ASCITES', 'HXCHF', 'HYPERMED', 'RENAFAIL', 'DIALYSIS', 'DISCANCR', 'STEROID', 'WTLOSS', 'BLEEDDIS', 'TRANSFUS', 'PRSODM', 'PRBUN', 'PRCREAT', 'PRWBC', 'PRHCT', 'PRPLATE', 'ASACLAS', 'BMI', 'RACE', 'IEDUR', 'CPTx', 'LOS', 'COMP', 'DISCHARGE']
	data = data[variables]

	data['SEX'] = data['SEX'].replace(['male'], 'Male')
	data['SEX'] = data['SEX'].replace(['female'], 'Female')

	print(data.columns)

	#Define outcomes.

	x = data
	y1 = data.pop('LOS')
	y2 = data.pop('COMP')
	y3 = data.pop('DISCHARGE')
	y1 = (y1 == "Yes").astype(int)
	y2 = (y2 == "Yes").astype(int)
	y3 = (y3 == "Yes").astype(int)

	categorical_columns = list(x.select_dtypes('object').columns)

	x = x.astype({col: "category" for col in categorical_columns})


	#Prepare data for LOS (y1).
	y1_data_xgb = xgb.DMatrix(x, label=y1, enable_categorical=True)
	y1_data_lgb = lgb.Dataset(x, label=y1)
	y1_data_cb = Pool(data=x, label=y1, cat_features=categorical_columns)

	#Prepare data for COMP (y2).
	y2_data_xgb = xgb.DMatrix(x, label=y2, enable_categorical=True)
	y2_data_lgb = lgb.Dataset(x, label=y2)
	y2_data_cb = Pool(data=x, label=y2, cat_features=categorical_columns)

	#Prepare data for DISCHARGE (y3).
	y3_data_xgb = xgb.DMatrix(x, label=y3, enable_categorical=True)
	y3_data_lgb = lgb.Dataset(x, label=y3)
	y3_data_cb = Pool(data=x, label=y3, cat_features=categorical_columns)


	#Prepare data for Random Forest models.

	x_rf = x
	categorical_columns = list(x_rf.select_dtypes('category').columns)
	x_rf = x_rf.astype({col: "category" for col in categorical_columns})
	le = sklearn.preprocessing.LabelEncoder()
	for col in categorical_columns:
	x_rf[col] = le.fit_transform(x_rf[col].astype(str))
	d1 = dict.fromkeys(x_rf.select_dtypes(np.int64).columns, str)
	x_rf = x_rf.astype(d1)


	#Assign unique values as answer options.





	unique_sex = list(data["SEX"].unique())
	unique_transt = list(data["TRANST"].unique())
	unique_surgspec = list(data["SURGSPEC"].unique())
	unique_diabetes = list(data["DIABETES"].unique())
	unique_smoke = list(data["SMOKE"].unique())
	unique_dyspnea = list(data["DYSPNEA"].unique())
	unique_fnstatus2 = list(data["FNSTATUS2"].unique())
	unique_hxcopd = list(data["HXCOPD"].unique())
	unique_ascites = list(data["ASCITES"].unique())
	unique_hypermed = list(data["HYPERMED"].unique())
	unique_hxchf = list(data["HXCHF"].unique())
	unique_dialysis = list(data["DIALYSIS"].unique())
	unique_discancr = list(data["DISCANCR"].unique())
	unique_steroid = list(data["STEROID"].unique())
	unique_wtloss = list(data["WTLOSS"].unique())
	unique_bleeddis = list(data["BLEEDDIS"].unique())
	unique_transfus = list(data["TRANSFUS"].unique())
	unique_asaclas = ['1-No Disturb', '2-Mild Disturb', '3-Severe Disturb']
	unique_race = list(data["RACE"].unique())
	unique_cpt = list(data["CPTx"].unique())
	unique_renafail = list(data["RENAFAIL"].unique())
	unique_iedur = list(data["IEDUR"].unique())
	unique_renafail.append('Yes')
	unique_ascites.append('Yes')


	#Assign hyperparameters.




	y1_xgb_params = {'objective': 'binary:logistic', 'booster': 'gbtree', 'lambda': 8.723774948284441e-07, 'alpha': 0.00023921492337533858, 'max_depth': 2, 'eta': 0.6597023213356437, 'gamma': 0.01139069218794266, 'grow_policy': 'depthwise'}
	y2_xgb_params = {'objective': 'binary:logistic', 'booster': 'gbtree', 'lambda': 0.0004117147096128777, 'alpha': 0.14128415600583139, 'max_depth': 6, 'eta': 2.3096020292129062e-07, 'gamma': 0.0029263515552855487, 'grow_policy': 'depthwise'}
	y3_xgb_params = {'objective': 'binary:logistic', 'booster': 'gbtree', 'lambda': 0.000135090421129263, 'alpha': 0.0001803091958347842, 'max_depth': 7, 'eta': 0.046836367148828446, 'gamma': 0.014989782116695525, 'grow_policy': 'depthwise'}

	y1_lgb_params = {'objective': 'binary', 'boosting_type': 'gbdt', 'lambda_l1': 0.06103319249396863, 'lambda_l2': 2.730288675256519e-07, 'num_leaves': 241, 'feature_fraction': 0.480924409088473, 'bagging_fraction': 0.5369659321937144, 'bagging_freq': 4, 'min_child_samples': 55}
	y2_lgb_params = {'objective': 'binary', 'boosting_type': 'gbdt', 'lambda_l1': 1.7986721496609696e-06, 'lambda_l2': 0.002957616416068077, 'num_leaves': 106, 'feature_fraction': 0.5360246434273803, 'bagging_fraction': 0.5820551564498964, 'bagging_freq': 6, 'min_child_samples': 84}
	y3_lgb_params = {'objective': 'binary', 'boosting_type': 'gbdt', 'lambda_l1': 8.520929262020913e-05, 'lambda_l2': 1.6655311531708117, 'num_leaves': 136, 'feature_fraction': 0.7509810402777333, 'bagging_fraction': 0.9102746088494693, 'bagging_freq': 1, 'min_child_samples': 55}

	y1_cb_params = {'objective': 'Logloss', 'colsample_bylevel': 0.07544378549787216, 'depth': 10, 'boosting_type': 'Plain', 'bootstrap_type': 'Bernoulli', 'subsample': 0.6389847599879461}
	y2_cb_params = {'objective': 'CrossEntropy', 'colsample_bylevel': 0.05028033319818594, 'depth': 3, 'boosting_type': 'Ordered', 'bootstrap_type': 'Bernoulli', 'subsample': 0.5050371164439088}
	y3_cb_params = {'objective': 'CrossEntropy', 'colsample_bylevel': 0.07153555363139168, 'depth': 11, 'boosting_type': 'Plain', 'bootstrap_type': 'MVS'}

	y1_rf_params = {'criterion': 'gini', 'max_features': None, 'max_depth': 62, 'n_estimators': 800, 'min_samples_leaf': 2, 'min_samples_split': 8}
	y2_rf_params = {'criterion': 'gini', 'max_features': None, 'max_depth': 65, 'n_estimators': 1900, 'min_samples_leaf': 1, 'min_samples_split': 10}
	y3_rf_params = {'criterion': 'gini', 'max_features': None, 'max_depth': 33, 'n_estimators': 1900, 'min_samples_leaf': 3, 'min_samples_split': 9}



	#Modeling for y1/LOS.

	y1_model_xgb = xgb.train(params=y1_xgb_params, dtrain=y1_data_xgb)
	y1_explainer_xgb = shap.TreeExplainer(y1_model_xgb)

	y1_model_lgb = lgb.train(params=y1_lgb_params, train_set=y1_data_lgb)
	y1_explainer_lgb = shap.TreeExplainer(y1_model_lgb)

	y1_model_cb = cb.train(pool=y1_data_cb, params=y1_cb_params)
	y1_explainer_cb = shap.TreeExplainer(y1_model_cb)

	from sklearn.ensemble import RandomForestClassifier as rf
	y1_rf = rf(**y1_rf_params)
	y1_model_rf = y1_rf.fit(x_rf, y1)
	y1_explainer_rf = shap.TreeExplainer(y1_model_rf)


	#Modeling for y2/COMP.

	y2_model_xgb = xgb.train(params=y2_xgb_params, dtrain=y2_data_xgb)
	y2_explainer_xgb = shap.TreeExplainer(y2_model_xgb)

	y2_model_lgb = lgb.train(params=y2_lgb_params, train_set=y2_data_lgb)
	y2_explainer_lgb = shap.TreeExplainer(y2_model_lgb)

	y2_model_cb = cb.train(pool=y2_data_cb, params=y2_cb_params)
	y2_explainer_cb = shap.TreeExplainer(y2_model_cb)

	from sklearn.ensemble import RandomForestClassifier as rf
	y2_rf = rf(**y2_rf_params)
	y2_model_rf = y2_rf.fit(x_rf, y2)
	y2_explainer_rf = shap.TreeExplainer(y2_model_rf)


	#Modeling for y3/DISCHARGE.

	y3_model_xgb = xgb.train(params=y3_xgb_params, dtrain=y3_data_xgb)
	y3_explainer_xgb = shap.TreeExplainer(y3_model_xgb)

	y3_model_lgb = lgb.train(params=y3_lgb_params, train_set=y3_data_lgb)
	y3_explainer_lgb = shap.TreeExplainer(y3_model_lgb)

	y3_model_cb = cb.train(pool=y3_data_cb, params=y3_cb_params)
	y3_explainer_cb = shap.TreeExplainer(y3_model_cb)

	from sklearn.ensemble import RandomForestClassifier as rf
	y3_rf = rf(**y3_rf_params)
	y3_model_rf = y3_rf.fit(x_rf, y3)
	y3_explainer_rf = shap.TreeExplainer(y3_model_rf)


	#Define predict for y1/LOS.


	def y1_predict_xgb(*args):
	df_xgb = pd.DataFrame([args], columns=x.columns)
	df_xgb = df_xgb.astype({col: "category" for col in categorical_columns})
	pos_pred = y1_model_xgb.predict(xgb.DMatrix(df_xgb, enable_categorical=True))
	return {"Prolonged LOS": float(pos_pred[0]), "Not Prolonged LOS": 1 - float(pos_pred[0])}



	def y1_predict_lgb(*args):
	df = pd.DataFrame([args], columns=data.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	pos_pred = y1_model_lgb.predict(df)
	return {"Prolonged LOS": float(pos_pred[0]), "Not Prolonged LOS": 1 - float(pos_pred[0])}



	def y1_predict_cb(*args):
	df_cb = pd.DataFrame([args], columns=x.columns)
	df_cb = df_cb.astype({col: "category" for col in categorical_columns})
	pos_pred = y1_model_cb.predict(Pool(df_cb, cat_features = categorical_columns), prediction_type='Probability')
	return {"Prolonged LOS": float(pos_pred[0][1]), "Not Prolonged LOS": float(pos_pred[0][0])}



	def y1_predict_rf(*args):
	df = pd.DataFrame([args], columns=x_rf.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	d = dict.fromkeys(df.select_dtypes(np.int64).columns, np.int32)
	df = df.astype(d)
	pos_pred = y1_model_rf.predict_proba(df)
	return {"Prolonged LOS": float(pos_pred[0][1]), "Not Prolonged LOS": float(pos_pred[0][0])}


	#Define predict for y2/COMP.

	def y2_predict_xgb(*args):
	df_xgb = pd.DataFrame([args], columns=x.columns)
	df_xgb = df_xgb.astype({col: "category" for col in categorical_columns})
	pos_pred = y2_model_xgb.predict(xgb.DMatrix(df_xgb, enable_categorical=True))
	return {"Major complications": float(pos_pred[0]), "No Major complications": 1 - float(pos_pred[0])}



	def y2_predict_lgb(*args):
	df = pd.DataFrame([args], columns=data.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	pos_pred = y2_model_lgb.predict(df)
	return {"Major complications": float(pos_pred[0]), "No Major complications": 1 - float(pos_pred[0])}



	def y2_predict_cb(*args):
	df_cb = pd.DataFrame([args], columns=x.columns)
	df_cb = df_cb.astype({col: "category" for col in categorical_columns})
	pos_pred = y2_model_cb.predict(Pool(df_cb, cat_features = categorical_columns), prediction_type='Probability')
	return {"Major complications": float(pos_pred[0][1]), "No Major complications": float(pos_pred[0][0])}



	def y2_predict_rf(*args):
	df = pd.DataFrame([args], columns=x_rf.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	d = dict.fromkeys(df.select_dtypes(np.int64).columns, np.int32)
	df = df.astype(d)
	pos_pred = y2_model_rf.predict_proba(df)
	return {"Major complications": float(pos_pred[0][1]), "No Major complications": float(pos_pred[0][0])}


	#Define predict for y3/DISCHARGE.


	def y3_predict_xgb(*args):
	df_xgb = pd.DataFrame([args], columns=x.columns)
	df_xgb = df_xgb.astype({col: "category" for col in categorical_columns})
	pos_pred = y3_model_xgb.predict(xgb.DMatrix(df_xgb, enable_categorical=True))
	return {"Non-home Discharge": float(pos_pred[0]), "Home Discharge": 1 - float(pos_pred[0])}



	def y3_predict_lgb(*args):
	df = pd.DataFrame([args], columns=data.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	pos_pred = y3_model_lgb.predict(df)
	return {"Non-home Discharge": float(pos_pred[0]), "Home Discharge": 1 - float(pos_pred[0])}



	def y3_predict_cb(*args):
	df_cb = pd.DataFrame([args], columns=x.columns)
	df_cb = df_cb.astype({col: "category" for col in categorical_columns})
	pos_pred = y3_model_cb.predict(Pool(df_cb, cat_features = categorical_columns), prediction_type='Probability')
	return {"Non-home Discharge": float(pos_pred[0][1]), "Home Discharge": float(pos_pred[0][0])}



	def y3_predict_rf(*args):
	df = pd.DataFrame([args], columns=x_rf.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	d = dict.fromkeys(df.select_dtypes(np.int64).columns, np.int32)
	df = df.astype(d)
	pos_pred = y3_model_rf.predict_proba(df)
	return {"Non-home Discharge": float(pos_pred[0][1]), "Home Discharge": float(pos_pred[0][0])}


	#Define interpret for y1/LOS.









	def y1_interpret_xgb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y1_explainer_xgb.shap_values(xgb.DMatrix(df, enable_categorical=True))
	scores_desc = list(zip(shap_values[0], x.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y1_interpret_lgb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y1_explainer_lgb.shap_values(df)
	scores_desc = list(zip(shap_values[0][0], x.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y1_interpret_cb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y1_explainer_cb.shap_values(Pool(df, cat_features = categorical_columns))
	scores_desc = list(zip(shap_values[0], x.columns))

	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y1_interpret_rf(*args):
	df = pd.DataFrame([args], columns=x_rf.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y1_explainer_rf.shap_values(df)
	scores_desc = list(zip(shap_values[0][0], x_rf.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m


	#Define interpret for y2/COMP.


	def y2_interpret_xgb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y2_explainer_xgb.shap_values(xgb.DMatrix(df, enable_categorical=True))
	scores_desc = list(zip(shap_values[0], x.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y2_interpret_lgb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y2_explainer_lgb.shap_values(df)
	scores_desc = list(zip(shap_values[0][0], x.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y2_interpret_cb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y2_explainer_cb.shap_values(Pool(df, cat_features = categorical_columns))
	scores_desc = list(zip(shap_values[0], x.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y2_interpret_rf(*args):
	df = pd.DataFrame([args], columns=x_rf.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y2_explainer_rf.shap_values(df)
	scores_desc = list(zip(shap_values[0][0], x_rf.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m


	#Define interpret for y3/DISCHARGE.


	def y3_interpret_xgb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y3_explainer_xgb.shap_values(xgb.DMatrix(df, enable_categorical=True))
	scores_desc = list(zip(shap_values[0], x.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y3_interpret_lgb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y3_explainer_lgb.shap_values(df)
	scores_desc = list(zip(shap_values[0][0], x.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y3_interpret_cb(*args):
	df = pd.DataFrame([args], columns=x.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y3_explainer_cb.shap_values(Pool(df, cat_features = categorical_columns))
	scores_desc = list(zip(shap_values[0], x.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m




	def y3_interpret_rf(*args):
	df = pd.DataFrame([args], columns=x_rf.columns)
	df = df.astype({col: "category" for col in categorical_columns})
	shap_values = y3_explainer_rf.shap_values(df)
	scores_desc = list(zip(shap_values[0][0], x_rf.columns))
	scores_desc = sorted(scores_desc)
	fig_m = plt.figure(facecolor='white')
	fig_m.set_size_inches(14, 10)
	plt.barh([s[1] for s in scores_desc], [s[0] for s in scores_desc])
	plt.title("Feature Shap Values", fontsize = 24, pad = 20, fontweight = 'bold')
	plt.yticks(fontsize=12)
	plt.xlabel("Shap Value", fontsize = 16, labelpad=8, fontweight = 'bold')
	plt.ylabel("Feature", fontsize = 16, labelpad=14, fontweight = 'bold')
	return fig_m


	with gr.Blocks(title="NSQIP-ST") as demo:

	gr.Markdown(
	"""
	<br/>
	<center><h2>NOT FOR CLINICAL USE</h2><center>
	<br/>
	<center><h1>Spinal Tumor Resection Outcomes</h1></center>
	<center><h2>Prediction Tool</h2></center>
	<br/>
	<center><h3>This web application should not be used to guide any clinical decisions.</h3><center>
	<br/>
	<center><i>The publication describing the details of this prediction tool can be reached from https://doi.org/10.3390/cancers15030812.</i><center>
	"""
	)

	with gr.Tab('Length of Stay'):

	gr.Markdown(
	"""

	### Prolonged Length of Stay Prediction Model for Spinal Tumor Resection
	"""
	)


	with gr.Row():

	with gr.Column():

	AGE = gr.Slider(label="Age", minimum=17, maximum=99, step=1, randomize=True)

	SEX = gr.Radio(
	label="Sex",
	choices=unique_sex,
	type='index',
	value=lambda: random.choice(unique_sex),
	)

	RACE = gr.Radio(
	label="Race",
	choices=unique_race,
	type='index',
	value=lambda: random.choice(unique_race),
	)

	HEIGHT = gr.Slider(label="Height (in meters)", minimum=1.0, maximum=2.25, step=0.01, randomize=True)

	WEIGHT = gr.Slider(label="Weight (in kilograms)", minimum=20, maximum=200, step=1, randomize=True)

	BMI = gr.Slider(label="BMI", minimum=10, maximum=70, step=1, randomize=True)

	TRANST = gr.Radio(
	label="Transfer Status",
	choices=unique_transt,
	type='index',
	value=lambda: random.choice(unique_transt),
	)

	SURGSPEC = gr.Radio(
	label="Surgical Specialty",
	choices=unique_surgspec,
	type='index',
	value=lambda: random.choice(unique_surgspec),
	)

	SMOKE = gr.Radio(
	label="Smoking Status",
	choices=unique_smoke,
	type='index',
	value=lambda: random.choice(unique_smoke),
	)

	DIABETES = gr.Radio(
	label="Diabetes",
	choices=unique_diabetes,
	type='index',
	value=lambda: random.choice(unique_diabetes),
	)

	DYSPNEA = gr.Radio(
	label="Dyspnea",
	choices=unique_dyspnea,
	type='index',
	value=lambda: random.choice(unique_dyspnea),
	)

	HXCOPD = gr.Radio(
	label="History of COPD",
	choices=unique_hxcopd,
	type='index',
	value=lambda: random.choice(unique_hxcopd),
	)

	ASCITES = gr.Radio(
	label="Ascites",
	choices=unique_ascites,
	type='index',
	value=lambda: random.choice(unique_ascites),
	)

	HXCHF = gr.Radio(
	label="History of Congestive Heart Failure",
	choices=unique_hxchf,
	type='index',
	value=lambda: random.choice(unique_hxchf),
	)

	HYPERMED = gr.Radio(
	label="Hypertension Despite Medication",
	choices=unique_hypermed,
	type='index',
	value=lambda: random.choice(unique_hypermed),
	)

	RENAFAIL = gr.Radio(
	label="Renal Failure",
	choices=unique_renafail,
	type='index',
	value=lambda: random.choice(unique_renafail),
	)

	DIALYSIS = gr.Radio(
	label="Dialysis",
	choices=unique_dialysis,
	type='index',
	value=lambda: random.choice(unique_dialysis),
	)

	STEROID = gr.Radio(
	label="Steroid",
	choices=unique_steroid,
	type='index',
	value=lambda: random.choice(unique_steroid),
	)

	WTLOSS = gr.Radio(
	label="Weight Loss",
	choices=unique_wtloss,
	type='index',
	value=lambda: random.choice(unique_wtloss),
	)

	BLEEDDIS = gr.Radio(
	label="Bleeding Disorder",
	choices=unique_bleeddis,
	type='index',
	value=lambda: random.choice(unique_bleeddis),
	)

	TRANSFUS = gr.Radio(
	label="Transfusion",
	choices=unique_transfus,
	type='index',
	value=lambda: random.choice(unique_transfus),
	)

	DISCANCR = gr.Radio(
	label="Disseminated Cancer",
	choices=unique_discancr,
	type='index',
	value=lambda: random.choice(unique_discancr),
	)

	FNSTATUS2 = gr.Radio(
	label="Functional Status",
	choices=unique_fnstatus2,
	type='index',
	value=lambda: random.choice(unique_fnstatus2),
	)

	PRSODM = gr.Slider(label="Sodium", minimum=min(x['PRSODM']), maximum=max(x['PRSODM']), step=1, randomize=True)

	PRBUN = gr.Slider(label="BUN", minimum=min(x['PRBUN']), maximum=max(x['PRBUN']), step=1, randomize=True)

	PRCREAT = gr.Slider(label="Creatine", minimum=min(x['PRCREAT']),maximum=max(x['PRCREAT']), step=0.1, randomize=True)

	PRWBC = gr.Slider(label="WBC", minimum=min(x['PRWBC']), maximum=max(x['PRWBC']), step=0.1, randomize=True)

	PRHCT = gr.Slider(label="Hematocrit", minimum=min(x['PRHCT']), maximum=max(x['PRHCT']), step=0.1, randomize=True)

	PRPLATE = gr.Slider(label="Platelet", minimum=min(x['PRPLATE']), maximum=max(x['PRPLATE']), step=1, randomize=True)

	ASACLAS = gr.Radio(
	label="ASA Class",
	choices=unique_asaclas,
	type='index',
	value=lambda: random.choice(unique_asaclas),

	)

	IEDUR = gr.Radio(
	label="Intradural or Extradural",
	choices=unique_iedur,
	type='index',
	value=lambda: random.choice(unique_iedur),
	)

	CPTx = gr.Radio(
	label="CPT",
	choices=unique_cpt,
	type='index',
	value=lambda: random.choice(unique_cpt),
	)

	with gr.Column():

	with gr.Row():
	y1_predict_btn_xgb = gr.Button(value="Predict (XGBoost)")
	y1_predict_btn_lgb = gr.Button(value="Predict (LightGBM)")
	y1_predict_btn_cb = gr.Button(value="Predict (CatBoost)")
	y1_predict_btn_rf = gr.Button(value="Predict (Random Forest)")
	label = gr.Label()











	with gr.Row():
	y1_interpret_btn_xgb = gr.Button(value="Explain (XGBoost)")
	y1_interpret_btn_lgb = gr.Button(value="Explain (LightGBM)")
	y1_interpret_btn_cb = gr.Button(value="Explain (CatBoost)")
	y1_interpret_btn_rf = gr.Button(value="Explain (Random Forest)")

	plot = gr.Plot()

	y1_predict_btn_xgb.click(
	y1_predict_xgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y1_predict_btn_lgb.click(
	y1_predict_lgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y1_predict_btn_cb.click(
	y1_predict_cb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y1_predict_btn_rf.click(
	y1_predict_rf,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y1_interpret_btn_xgb.click(
	y1_interpret_xgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y1_interpret_btn_lgb.click(
	y1_interpret_lgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y1_interpret_btn_cb.click(
	y1_interpret_cb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y1_interpret_btn_rf.click(
	y1_interpret_rf,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	with gr.Tab('Major Complications'):

	gr.Markdown(
	"""

	### Major Complication Prediction Model for Spinal Tumor Resection
	"""
	)


	with gr.Row():

	with gr.Column():

	AGE = gr.Slider(label="Age", minimum=17, maximum=99, step=1, randomize=True)

	SEX = gr.Radio(
	label="Sex",
	choices=unique_sex,
	type='index',
	value=lambda: random.choice(unique_sex),
	)

	RACE = gr.Radio(
	label="Race",
	choices=unique_race,
	type='index',
	value=lambda: random.choice(unique_race),
	)

	HEIGHT = gr.Slider(label="Height (in meters)", minimum=1.0, maximum=2.25, step=0.01, randomize=True)

	WEIGHT = gr.Slider(label="Weight (in kilograms)", minimum=20, maximum=200, step=1, randomize=True)

	BMI = gr.Slider(label="BMI", minimum=10, maximum=70, step=1, randomize=True)

	TRANST = gr.Radio(
	label="Transfer Status",
	choices=unique_transt,
	type='index',
	value=lambda: random.choice(unique_transt),
	)

	SURGSPEC = gr.Radio(
	label="Surgical Specialty",
	choices=unique_surgspec,
	type='index',
	value=lambda: random.choice(unique_surgspec),
	)

	SMOKE = gr.Radio(
	label="Smoking Status",
	choices=unique_smoke,
	type='index',
	value=lambda: random.choice(unique_smoke),
	)

	DIABETES = gr.Radio(
	label="Diabetes",
	choices=unique_diabetes,
	type='index',
	value=lambda: random.choice(unique_diabetes),
	)

	DYSPNEA = gr.Radio(
	label="Dyspnea",
	choices=unique_dyspnea,
	type='index',
	value=lambda: random.choice(unique_dyspnea),
	)

	HXCOPD = gr.Radio(
	label="History of COPD",
	choices=unique_hxcopd,
	type='index',
	value=lambda: random.choice(unique_hxcopd),
	)

	ASCITES = gr.Radio(
	label="Ascites",
	choices=unique_ascites,
	type='index',
	value=lambda: random.choice(unique_ascites),
	)

	HXCHF = gr.Radio(
	label="History of Congestive Heart Failure",
	choices=unique_hxchf,
	type='index',
	value=lambda: random.choice(unique_hxchf),
	)

	HYPERMED = gr.Radio(
	label="Hypertension Despite Medication",
	choices=unique_hypermed,
	type='index',
	value=lambda: random.choice(unique_hypermed),
	)

	RENAFAIL = gr.Radio(
	label="Renal Failure",
	choices=unique_renafail,
	type='index',
	value=lambda: random.choice(unique_renafail),
	)

	DIALYSIS = gr.Radio(
	label="Dialysis",
	choices=unique_dialysis,
	type='index',
	value=lambda: random.choice(unique_dialysis),
	)

	STEROID = gr.Radio(
	label="Steroid",
	choices=unique_steroid,
	type='index',
	value=lambda: random.choice(unique_steroid),
	)

	WTLOSS = gr.Radio(
	label="Weight Loss",
	choices=unique_wtloss,
	type='index',
	value=lambda: random.choice(unique_wtloss),
	)

	BLEEDDIS = gr.Radio(
	label="Bleeding Disorder",
	choices=unique_bleeddis,
	type='index',
	value=lambda: random.choice(unique_bleeddis),
	)

	TRANSFUS = gr.Radio(
	label="Transfusion",
	choices=unique_transfus,
	type='index',
	value=lambda: random.choice(unique_transfus),
	)

	DISCANCR = gr.Radio(
	label="Disseminated Cancer",
	choices=unique_discancr,
	type='index',
	value=lambda: random.choice(unique_discancr),
	)

	FNSTATUS2 = gr.Radio(
	label="Functional Status",
	choices=unique_fnstatus2,
	type='index',
	value=lambda: random.choice(unique_fnstatus2),
	)

	PRSODM = gr.Slider(label="Sodium", minimum=min(x['PRSODM']), maximum=max(x['PRSODM']), step=1, randomize=True)

	PRBUN = gr.Slider(label="BUN", minimum=min(x['PRBUN']), maximum=max(x['PRBUN']), step=1, randomize=True)

	PRCREAT = gr.Slider(label="Creatine", minimum=min(x['PRCREAT']),maximum=max(x['PRCREAT']), step=0.1, randomize=True)

	PRWBC = gr.Slider(label="WBC", minimum=min(x['PRWBC']), maximum=max(x['PRWBC']), step=0.1, randomize=True)

	PRHCT = gr.Slider(label="Hematocrit", minimum=min(x['PRHCT']), maximum=max(x['PRHCT']), step=0.1, randomize=True)

	PRPLATE = gr.Slider(label="Platelet", minimum=min(x['PRPLATE']), maximum=max(x['PRPLATE']), step=1, randomize=True)

	ASACLAS = gr.Radio(
	label="ASA Class",
	choices=unique_asaclas,
	type='index',
	value=lambda: random.choice(unique_asaclas),

	)

	IEDUR = gr.Radio(
	label="Intradural or Extradural",
	choices=unique_iedur,
	type='index',
	value=lambda: random.choice(unique_iedur),
	)

	CPTx = gr.Radio(
	label="CPT",
	choices=unique_cpt,
	type='index',
	value=lambda: random.choice(unique_cpt),
	)

	with gr.Column():

	with gr.Row():
	y2_predict_btn_xgb = gr.Button(value="Predict (XGBoost)")
	y2_predict_btn_lgb = gr.Button(value="Predict (LightGBM)")
	y2_predict_btn_cb = gr.Button(value="Predict (CatBoost)")
	y2_predict_btn_rf = gr.Button(value="Predict (Random Forest)")
	label = gr.Label()











	with gr.Row():
	y2_interpret_btn_xgb = gr.Button(value="Explain (XGBoost)")
	y2_interpret_btn_lgb = gr.Button(value="Explain (LightGBM)")
	y2_interpret_btn_cb = gr.Button(value="Explain (CatBoost)")
	y2_interpret_btn_rf = gr.Button(value="Explain (Random Forest)")

	plot = gr.Plot()

	y2_predict_btn_xgb.click(
	y2_predict_xgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y2_predict_btn_lgb.click(
	y2_predict_lgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y2_predict_btn_cb.click(
	y2_predict_cb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y2_predict_btn_rf.click(
	y2_predict_rf,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y2_interpret_btn_xgb.click(
	y2_interpret_xgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y2_interpret_btn_lgb.click(
	y2_interpret_lgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y2_interpret_btn_cb.click(
	y2_interpret_cb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y2_interpret_btn_rf.click(
	y2_interpret_rf,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	with gr.Tab('Non-home Discharge'):

	gr.Markdown(
	"""

	### Non-home Discharge Prediction Model for Spinal Tumor Resection
	"""
	)


	with gr.Row():

	with gr.Column():

	AGE = gr.Slider(label="Age", minimum=17, maximum=99, step=1, randomize=True)

	SEX = gr.Radio(
	label="Sex",
	choices=unique_sex,
	type='index',
	value=lambda: random.choice(unique_sex),
	)

	RACE = gr.Radio(
	label="Race",
	choices=unique_race,
	type='index',
	value=lambda: random.choice(unique_race),
	)

	HEIGHT = gr.Slider(label="Height (in meters)", minimum=1.0, maximum=2.25, step=0.01, randomize=True)

	WEIGHT = gr.Slider(label="Weight (in kilograms)", minimum=20, maximum=200, step=1, randomize=True)

	BMI = gr.Slider(label="BMI", minimum=10, maximum=70, step=1, randomize=True)

	TRANST = gr.Radio(
	label="Transfer Status",
	choices=unique_transt,
	type='index',
	value=lambda: random.choice(unique_transt),
	)

	SURGSPEC = gr.Radio(
	label="Surgical Specialty",
	choices=unique_surgspec,
	type='index',
	value=lambda: random.choice(unique_surgspec),
	)

	SMOKE = gr.Radio(
	label="Smoking Status",
	choices=unique_smoke,
	type='index',
	value=lambda: random.choice(unique_smoke),
	)

	DIABETES = gr.Radio(
	label="Diabetes",
	choices=unique_diabetes,
	type='index',
	value=lambda: random.choice(unique_diabetes),
	)

	DYSPNEA = gr.Radio(
	label="Dyspnea",
	choices=unique_dyspnea,
	type='index',
	value=lambda: random.choice(unique_dyspnea),
	)

	HXCOPD = gr.Radio(
	label="History of COPD",
	choices=unique_hxcopd,
	type='index',
	value=lambda: random.choice(unique_hxcopd),
	)

	ASCITES = gr.Radio(
	label="Ascites",
	choices=unique_ascites,
	type='index',
	value=lambda: random.choice(unique_ascites),
	)

	HXCHF = gr.Radio(
	label="History of Congestive Heart Failure",
	choices=unique_hxchf,
	type='index',
	value=lambda: random.choice(unique_hxchf),
	)

	HYPERMED = gr.Radio(
	label="Hypertension Despite Medication",
	choices=unique_hypermed,
	type='index',
	value=lambda: random.choice(unique_hypermed),
	)

	RENAFAIL = gr.Radio(
	label="Renal Failure",
	choices=unique_renafail,
	type='index',
	value=lambda: random.choice(unique_renafail),
	)

	DIALYSIS = gr.Radio(
	label="Dialysis",
	choices=unique_dialysis,
	type='index',
	value=lambda: random.choice(unique_dialysis),
	)

	STEROID = gr.Radio(
	label="Steroid",
	choices=unique_steroid,
	type='index',
	value=lambda: random.choice(unique_steroid),
	)

	WTLOSS = gr.Radio(
	label="Weight Loss",
	choices=unique_wtloss,
	type='index',
	value=lambda: random.choice(unique_wtloss),
	)

	BLEEDDIS = gr.Radio(
	label="Bleeding Disorder",
	choices=unique_bleeddis,
	type='index',
	value=lambda: random.choice(unique_bleeddis),
	)

	TRANSFUS = gr.Radio(
	label="Transfusion",
	choices=unique_transfus,
	type='index',
	value=lambda: random.choice(unique_transfus),
	)

	DISCANCR = gr.Radio(
	label="Disseminated Cancer",
	choices=unique_discancr,
	type='index',
	value=lambda: random.choice(unique_discancr),
	)

	FNSTATUS2 = gr.Radio(
	label="Functional Status",
	choices=unique_fnstatus2,
	type='index',
	value=lambda: random.choice(unique_fnstatus2),
	)

	PRSODM = gr.Slider(label="Sodium", minimum=min(x['PRSODM']), maximum=max(x['PRSODM']), step=1, randomize=True)

	PRBUN = gr.Slider(label="BUN", minimum=min(x['PRBUN']), maximum=max(x['PRBUN']), step=1, randomize=True)

	PRCREAT = gr.Slider(label="Creatine", minimum=min(x['PRCREAT']),maximum=max(x['PRCREAT']), step=0.1, randomize=True)

	PRWBC = gr.Slider(label="WBC", minimum=min(x['PRWBC']), maximum=max(x['PRWBC']), step=0.1, randomize=True)

	PRHCT = gr.Slider(label="Hematocrit", minimum=min(x['PRHCT']), maximum=max(x['PRHCT']), step=0.1, randomize=True)

	PRPLATE = gr.Slider(label="Platelet", minimum=min(x['PRPLATE']), maximum=max(x['PRPLATE']), step=1, randomize=True)

	ASACLAS = gr.Radio(
	label="ASA Class",
	choices=unique_asaclas,
	type='index',
	value=lambda: random.choice(unique_asaclas),

	)

	IEDUR = gr.Radio(
	label="Intradural or Extradural",
	choices=unique_iedur,
	type='index',
	value=lambda: random.choice(unique_iedur),
	)

	CPTx = gr.Radio(
	label="CPT",
	choices=unique_cpt,
	type='index',
	value=lambda: random.choice(unique_cpt),
	)

	with gr.Column():

	with gr.Row():
	y3_predict_btn_xgb = gr.Button(value="Predict (XGBoost)")
	y3_predict_btn_lgb = gr.Button(value="Predict (LightGBM)")
	y3_predict_btn_cb = gr.Button(value="Predict (CatBoost)")
	y3_predict_btn_rf = gr.Button(value="Predict (Random Forest)")
	label = gr.Label()











	with gr.Row():
	y3_interpret_btn_xgb = gr.Button(value="Explain (XGBoost)")
	y3_interpret_btn_lgb = gr.Button(value="Explain (LightGBM)")
	y3_interpret_btn_cb = gr.Button(value="Explain (CatBoost)")
	y3_interpret_btn_rf = gr.Button(value="Explain (Random Forest)")

	plot = gr.Plot()

	y3_predict_btn_xgb.click(
	y3_predict_xgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]









	)

	y3_predict_btn_lgb.click(
	y3_predict_lgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y3_predict_btn_cb.click(
	y3_predict_cb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y3_predict_btn_rf.click(
	y3_predict_rf,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[label]
	)

	y3_interpret_btn_xgb.click(
	y3_interpret_xgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y3_interpret_btn_lgb.click(
	y3_interpret_lgb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y3_interpret_btn_cb.click(
	y3_interpret_cb,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	y3_interpret_btn_rf.click(
	y3_interpret_rf,
	inputs=[SEX, TRANST, AGE, SURGSPEC, HEIGHT, WEIGHT, DIABETES, SMOKE, DYSPNEA, FNSTATUS2, HXCOPD, ASCITES, HXCHF, HYPERMED, RENAFAIL, DIALYSIS, DISCANCR, STEROID, WTLOSS, BLEEDDIS, TRANSFUS, PRSODM, PRBUN, PRCREAT, PRWBC, PRHCT, PRPLATE, ASACLAS, BMI, RACE, IEDUR, CPTx,],
	outputs=[plot],
	)

	gr.Markdown(
	"""
	<center><h2>Disclaimer</h2>
	<center>
	The American College of Surgeons National Surgical Quality Improvement Program and the hospitals participating in the ACS NSQIP are the source of the data used herein; they have not been verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors. The predictive tool located on this web page is for healthcare professionals' use only. This prediction tool should not be used in place of professional medical service for any disease or concern. Users of the prediction tool shouldn't base their decisions about their own health issues on the information presented here. You should ask any questions to your own doctor or another healthcare professional. The authors of the study mentioned above make no guarantees or representations, either express or implied, as to the completeness, timeliness, comparative or contentious nature, or utility of any information contained in or referred to in this prediction tool. The risk associated with using this prediction tool or the information in this predictive tool is not at all assumed by the authors. The information contained in the prediction tools may be outdated, not complete, or incorrect because health-related information is subject to frequent change and multiple confounders. No express or implied doctor-patient relationship is established by using the prediction tool. The prediction tools on this website are not validated by the authors. Users of the tool are not contacted by the authors, who also do not record any specific information about them. You are hereby advised to seek the advice of a doctor or other qualified healthcare provider before making any decisions, acting, or refraining from acting in response to any healthcare problem or issue you may be experiencing at any time, now or in the future. By using the prediction tool, you acknowledge and agree that neither the authors nor any other party are or will be liable or otherwise responsible for any decisions you make, actions you take, or actions you choose not to take as a result of using any information presented here.
	<br/>
	<h4>By using this tool, you accept all of the above terms.<h4/>
	</center>
	"""
	)

	demo.launch()