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README.md

@@ -1,27 +1,126 @@
 ---
-license: cc-by-4.0
 library_name: scvi-tools
+license: cc-by-4.0
 tags:
 - biology
 - genomics
 - single-cell
 - model_cls_name:CondSCVI
-- scvi_version:1.1.0
-- anndata_version:0.10.3
+- scvi_version:1.2.0
+- anndata_version:0.11.1
 - modality:rna
-- tissue:Eye
+- tissue:various
 - annotated:True
 ---
 
-# Description
 
-Tabula Sapiens is a benchmark, first-draft human cell atlas of nearly 500,000 cells from 24 organs of 15 normal human subjects.
+CondSCVI is a variational inference model for single-cell RNA-seq data that can learn an underlying
+latent space. The predictions of the model are meant to be afterward
+used for deconvolution of a second spatial transcriptomics dataset in DestVI. DestVI predicts the
+cell-type proportions as well as cell type-specific activation state
+in the spatial data.
 
-# Model properties
+CondSCVI takes as input a scRNA-seq gene expression matrix with cells and genes as well as a
+cell-type annotation for all cells.
+We provide an extensive [user guide](https://docs.scvi-tools.org/en/1.2.0/user_guide/models/destvi.html)
+for DestVI including a description of CondSCVI.
 
-Many model properties are in the model tags. Some more are listed below.
+- See our original manuscript for further details of the model:
+[DestVI manuscript](https://www.nature.com/articles/s41587-022-01272-8).
+- See our manuscript on [scvi-hub](https://www.biorxiv.org/content/10.1101/2024.03.01.582887v2)
+how to leverage pre-trained models.
 
-**model_init_params**:
+
+# Model Description
+
+Tabula Sapiens is a benchmark, first-draft human cell atlas of nearly 500,000 cells from 24 organs of 15 normal human subjects.
+
+# Metrics
+
+We provide here key performance metrics for the uploaded model, if provided by the data uploader.
+
+<details>
+<summary><strong>Coefficient of variation</strong></summary>
+
+The cell-wise coefficient of variation summarizes how well variation between different cells is
+preserved by the generated model expression. Below a squared Pearson correlation coefficient of 0.4
+, we would recommend not to use generated data for downstream analysis, while the generated latent
+space might still be useful for analysis.
+
+**Cell-wise Coefficient of Variation**:
+
+| Metric                  | Training Value | Validation Value |
+|-------------------------|----------------|------------------|
+| Mean Absolute Error | 1.92  | 1.93           |
+| Pearson Correlation | 0.76  | 0.75  |
+| Spearman Correlation | 0.76 | 0.74  |
+| R² (R-Squared) | 0.46  | 0.44      |
+
+The gene-wise coefficient of variation summarizes how well variation between different genes is
+preserved by the generated model expression. This value is usually quite high.
+
+**Gene-wise Coefficient of Variation**:
+
+| Metric                  | Training Value |
+|-------------------------|----------------|
+| Mean Absolute Error | 23.52   |
+| Pearson Correlation | 0.25  |
+| Spearman Correlation | 0.31 |
+| R² (R-Squared) | -9.26  |
+
+</details>
+
+<details>
+<summary><strong>Differential expression metric</strong></summary>
+
+The differential expression metric provides a summary of the differential expression analysis
+between cell types or input clusters. We provide here the F1-score, Pearson Correlation
+Coefficient of Log-Foldchanges, Spearman Correlation Coefficient, and Area Under the Precision
+Recall Curve (AUPRC) for the differential expression analysis using Wilcoxon Rank Sum test for each
+cell-type.
+
+**Differential expression**:
+
+| Index | gene_f1 | lfc_mae | lfc_pearson | lfc_spearman | roc_auc | pr_auc | n_cells |
+| --- | --- | --- | --- | --- | --- | --- | --- |
+| conjunctival epithelial cell | 0.86 | 2.12 | 0.41 | 0.73 | 0.36 | 0.92 | 4587.00 |
+| corneal epithelial cell | 0.85 | 3.42 | 0.07 | 0.43 | 0.48 | 0.92 | 1488.00 |
+| eye photoreceptor cell | 0.70 | 4.86 | 0.26 | 0.44 | 0.42 | 0.86 | 891.00 |
+| keratocyte | 0.79 | 3.80 | 0.39 | 0.52 | 0.51 | 0.84 | 595.00 |
+| retinal blood vessel endothelial cell | 0.50 | 4.36 | 0.35 | 0.41 | 0.54 | 0.86 | 466.00 |
+| Mueller cell | 0.46 | 5.18 | 0.33 | 0.47 | 0.48 | 0.81 | 360.00 |
+| stromal cell | 0.59 | 1.91 | 0.42 | 0.60 | 0.37 | 0.69 | 325.00 |
+| T cell | 0.26 | 7.06 | 0.16 | 0.13 | 0.40 | 0.80 | 237.00 |
+| microglial cell | 0.27 | 6.03 | 0.16 | 0.19 | 0.46 | 0.76 | 209.00 |
+| radial glial cell | 0.62 | 4.05 | 0.31 | 0.47 | 0.53 | 0.81 | 195.00 |
+| dendritic cell | 0.47 | 7.61 | 0.25 | 0.16 | 0.45 | 0.78 | 182.00 |
+| melanocyte | 0.30 | 5.48 | 0.41 | 0.25 | 0.46 | 0.73 | 144.00 |
+| stem cell | 0.44 | 4.51 | 0.40 | 0.27 | 0.48 | 0.63 | 144.00 |
+| macrophage | 0.28 | 6.21 | 0.29 | 0.24 | 0.48 | 0.74 | 108.00 |
+| endothelial cell | 0.46 | 6.09 | 0.40 | 0.36 | 0.42 | 0.69 | 105.00 |
+| B cell | 0.39 | 9.19 | 0.19 | 0.16 | 0.44 | 0.78 | 102.00 |
+| fibroblast | 0.46 | 5.48 | 0.43 | 0.40 | 0.43 | 0.66 | 95.00 |
+| surface ectodermal cell | 0.41 | 6.47 | 0.45 | 0.31 | 0.45 | 0.70 | 54.00 |
+| epithelial cell of lacrimal sac | 0.28 | 6.41 | 0.43 | 0.16 | 0.46 | 0.68 | 52.00 |
+| retinal pigment epithelial cell | 0.13 | 11.50 | 0.05 | 0.07 | 0.44 | 0.76 | 49.00 |
+| plasma cell | 0.10 | 7.87 | 0.33 | 0.16 | 0.49 | 0.86 | 46.00 |
+| monocyte | 0.25 | 7.86 | 0.34 | 0.17 | 0.43 | 0.69 | 44.00 |
+| fat cell | 0.29 | 6.64 | 0.33 | 0.16 | 0.48 | 0.70 | 44.00 |
+| retinal bipolar neuron | 0.20 | 7.49 | 0.32 | 0.28 | 0.40 | 0.64 | 34.00 |
+| erythroid lineage cell | 0.11 | 15.97 | 0.01 | 0.01 | 0.51 | 0.96 | 30.00 |
+| CD4-positive, alpha-beta T cell | 0.22 | 7.92 | 0.34 | 0.18 | 0.40 | 0.58 | 23.00 |
+| pigmented ciliary epithelial cell | 0.28 | 6.96 | 0.44 | 0.23 | 0.38 | 0.63 | 17.00 |
+
+</details>
+
+# Model Properties
+
+We provide here key parameters used to setup and train the model.
+
+<details>
+<summary><strong>Model Parameters</strong></summary>
+
+These provide the settings to setup the original model:
 ```json
 {
     "n_hidden": 128,
@@ -32,48 +131,63 @@ Many model properties are in the model tags. Some more are listed below.
 }
 ```
 
-**model_setup_anndata_args**:
+</details>
+
+<details>
+<summary><strong>Setup Data Arguments</strong></summary>
+
+Arguments passed to setup_anndata of the original model:
 ```json
 {
     "labels_key": "cell_ontology_class",
-    "layer": null
+    "layer": null,
+    "batch_key": null
 }
 ```
 
-**model_summary_stats**:
-| Summary Stat Key | Value |
-|------------------|-------|
-|     n_cells      | 10626 |
-|     n_labels     |  27   |
-|      n_vars      | 4000  |
+</details>
+
+<details>
+<summary><strong>Data Registry</strong></summary>
 
-**model_data_registry**:
+Registry elements for AnnData manager:
 | Registry Key |    scvi-tools Location    |
 |--------------|---------------------------|
 |      X       |          adata.X          |
 |    labels    | adata.obs['_scvi_labels'] |
 
-**model_parent_module**: scvi.model
+- **Data is Minified**: False
+
+</details>
+
+<details>
+<summary><strong>Summary Statistics</strong></summary>
+
+| Summary Stat Key | Value |
+|------------------|-------|
+|     n_cells      | 10626 |
+|     n_labels     |  27   |
+|      n_vars      | 3000  |
 
-**data_is_minified**: False
+</details>
 
-# Training data
 
-This is an optional link to where the training data is stored if it is too large
-to host on the huggingface Model hub.
+<details>
+<summary><strong>Training</strong></summary>
 
 <!-- If your model is not uploaded with any data (e.g., minified data) on the Model Hub, then make
-sure to provide this field if you want users to be able to access your training data. See the scvi-tools
-documentation for details. -->
+sure to provide this field if you want users to be able to access your training data. See the
+scvi-tools documentation for details. -->
+**Training data url**: Not provided by uploader
 
-Training data url: https://zenodo.org/records/7608635/files/Eye_training_data.h5ad
+If provided by the original uploader, for those interested in understanding or replicating the
+training process, the code is available at the link below.
 
-# Training code
+**Training Code URL**: https://github.com/YosefLab/scvi-hub-models/blob/main/src/scvi_hub_models/TS_train_all_tissues.ipynb
 
-This is an optional link to the code used to train the model.
+</details>
 
-Training code url: N/A
 
 # References
 
-The Tabula Sapiens Consortium. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science, May 2022. doi:10.1126/science.abl4896
+The Tabula Sapiens Consortium. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science, May 2022. doi:10.1126/science.abl4896