| Causes an allergic reaction in human. Allergen from olive pollen. Important in Mediterranean countries and California. Its prevalence is related to the geographic area | |
| Causes an allergic reaction in human. Is the cause of the celiac disease, also known as celiac sprue or gluten-sensitive enteropathy (By similarity) | |
| Causes an allergic reaction in human (PubMed:34146442). Binds to IgE of patients allergic to hazelnuts (PubMed:34146442) | |
| Causes an allergic reaction in human. Binds to IgE | |
| Causes an allergic reaction in human | |
| Causes an allergic reaction in human. Food allergen | |
| Causes an allergic reaction in human (Ref.1, PubMed:19173789, PubMed:19217563). Binds to IgE in 57% of the 7 patients tested allergic to oriental plane-tree pollen (Ref.1, PubMed:19217563). Binds to IgE in 21% of the 19 patients tested allergic to oriental plane-tree pollen (PubMed:19173789) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to shrimp (PubMed:18760458, PubMed:20471069, PubMed:22192087). Natural boiled protein binds to IgE in 55% of the 38 shrimp-allergic patients tested. Recombinant protein binds to IgE in 89% of the 19 patients tested allergic to the natural protein (PubMed:18760458). Epitope diversity and the frequency and intensity of IgE-binding is significantly more pronounced in children than in adults (PubMed:20471069). Patients (children or adults) with positive double-blind placebo-controlled food challenge (DBPCFC) to shrimp have a more frequent, intense and diverse recognition of the epitopes of this protein than those with negative challenge (PubMed:22192087) | |
| Causes an allergic reaction in human. Lup an 1 is the major lupin allergen | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to London plane tree pollen (PubMed:12859456, PubMed:11906336, PubMed:16179793, PubMed:17177673). Binds to IgE in 83% of the 42 patients tested (PubMed:12859456). Binds to IgE in 92% of the 12 patients tested (PubMed:11906336). Binds to IgE in 79% of the 47 Spanish patients tested (PubMed:16179793). Binds to IgE in 75% of the 26 patients tested (PubMed:17177673). Binds to IgE in 83% of the 18 patients tested allergic London plane tree pollen as well as other pollens including grass and olive (PubMed:11906336) | |
| Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis | |
| Causes an allergic reaction in human (PubMed:10545763, PubMed:1710630, PubMed:17845417). Binds to IgE in 30% of the 10 patients tested allergic to D.pteronyssinus, the European house dust mite (HDM) (PubMed:10545763). Binds to IgE in 46% of the 27 adults and in 25% of the 20 children tested allergic to mites (PubMed:1710630). The IgE of the mite-atopic tropical Australian Aboriginal patients binds unusually mainly to this protein, whereas this protein is a minor allergen in mite-atopic urban patients from Perth, including three patients of Aboriginal origin. IgE-binding to this protein is not the result of cross-reactivity to another amylase in these patients since IgE-binding to the extract from Culicoides, the biting midges common in the north west of Western Australia, is negative, as is the IgE-binding to the major allergen of B.tropicalis, a prevalent mite in the tropics. It is also unlikely that the IgE is induced by parasites, because parasitic infections also induce IgG4 antibody, which is mostly absent in the atopic Aboriginal population, although antibody to the Der p 4 allergen is occasionally detected. The amylases in mollusks could potentially be sensitizing, but mollusks are rarely consumed in the Aboriginal community (PubMed:17845417). The allergenicity of this protein is dependent on the presence of the disulfide bonds (PubMed:1710630). Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis (Probable) | |
| Causes an allergic reaction in human. Binds to IgE in 71% of the 7 patients tested allergic to tree pollen, including hazel and birch pollen | |
| Causes an allergic reaction in human. Causes grass pollen allergy | |
| Causes an allergic reaction in human (PubMed:18996574). Binds to IgE of patients with severe allergic reactions (anaphylaxis) to soybean (PubMed:18996574). Causes an allergic reaction in rat (PubMed:17823539). Induces IgE-mediated passive cutaneous anaphylactic reactions coupled to mast cell degranulation and histamine release after intragastric absorption (PubMed:17823539) | |
| Causes an allergic reaction in human. Binds IgE | |
| Causes an allergic reaction in human (PubMed:22093066, PubMed:32710524, PubMed:33547733). Recombinant protein binds to IgE in 57% and 68% of the 23 and 40 carrot-allergic patients tested in non-reducing immunoblot and immunoCAP assay, respectively (PubMed:22093066). Recombinant protein binds to IgE in 79% of the 19 carrot-allergic patients tested by the immunoCAP method (PubMed:33547733). Induces beta-hexosaminidase release from humanized rat basophilic leukemia cells at both pH 7 and pH 3 at room temperature as well as after heating to 95 degrees Celsius for 30 minutes (PubMed:32710524, PubMed:33547733). Induces histamine release from IgE-stripped and passively human serum-sensitized basophils (PubMed:22093066) | |
| Causes an allergic reaction in human. The most common cause of insect venom allergy in the southeastern United States is the imported fire ant | |
| Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding | |
| Causes an allergic reaction in human. Is a cause of type I allergic reactions in Europe, North America and USSR | |
| May cause an allergic reaction in human | |
| Causes an allergic reaction in human. Causes grass pollen allergy. Binds to IgE | |
| Causes an allergic reaction in human. Binds to IgE in 78% of latex allergic patients. IgE binding is abolished by deglycosylation | |
| Causes an allergic reaction in human. Binds to IgE. Sensitization is common in subjects who are repeatedly exposed to G.max dust. Common symptoms are bronchial asthma and allergic rhinitis | |
| Causes an allergic reaction in human (PubMed:12065909). Binds to IgE (PubMed:12065909) | |
| Causes an allergic reaction in human. Binds to IgE in 14% of the 104 patients tested allergic to cockroach. Calcium depletion by 10 mM ethylene glycol bis(2-aminoethyl)tetraacetic acid (EGTA) does not significantly affect IgE-binding, but addition of 10 mM CaCl(2) after calcium depletion increases IgE-binding by approximately 2-fold | |
| Causes an allergic reaction in human (PubMed:16328735, PubMed:18442249). Binds to IgE from the serum of kiwi-allergic patients | |
| Causes an allergic reaction in human. Binds to IgE in 100% of the 5 shrimp-allergic patients tested | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to buckwheat (PubMed:21645012, PubMed:29306152, PubMed:33412487). Binds to IgE in 74% of the 23 tartarian buckwheat-allergic patients tested (PubMed:29306152). IgE-binding of the natural and recombinant protein is unaffected by heat treatment or pepsin digestion (PubMed:21645012, PubMed:29306152) | |
| Causes an allergic reaction in human (PubMed:25445830, PubMed:31545417). Recombinant protein binds to IgE in 100% of the 40 patients tested allergic to house dust mite (HDM). 50% of the 10 HDM-allergic patients tested have positive skin prick test (SPT) reactions to the recombinant protein (PubMed:25445830). Recombinant protein binds to IgE in 100% of the 15 HDM-allergic patients tested (PubMed:31545417) | |
| Causes an allergic reaction in human. Binds to IgE in all of the 32 patients tested allergic to sesame seeds | |
| Causes an allergic reaction in human. Binds to IgE and associated with delayed type hypersensitivity | |
| Causes an allergic reaction in human. Binds to IgE in all 28 patients tested allergic to fish. IgE-binding is greatly reduced by treatment with periodate indicating the presence of carbohydrate-containing epitopes. Calcium depletion results in more than 50% reduction in IgE-binding in 9 patients out of 14 tested. Assays performed under reducing conditions do not affect IgE-binding | |
| Causes an allergic reaction in human. Binds to IgE in 80% of the 15 patients tested allergic to oysters | |
| Causes an allergic reaction in human. Important allergen of apple fruits that is associated with IgE-mediated symptoms in apple allergic individuals | |
| Causes an allergic reaction in human. Major latex allergen, a major cause of anaphylaxis in susceptible individuals, especially health care workers. 92% of health care workers with latex allergy have IgE specific to the Hev b 5 protein | |
| Causes an allergic reaction in human. Major allergen from olive pollen. Important in Mediterranean countries | |
| Causes an allergic reaction in human. Recombinant protein binds to IgE in patients allergic to house dust mite (HDM) (PubMed:18445190, PubMed:24874917, PubMed:29319884). Recombinant protein binds to IgE in 26% of the 117 patients tested living in urban area in Austria allergic to European HDM (PubMed:18445190). Recombinant protein binds to IgE in 25% of the 96 patients tested living in Bangkok allergic to European HDM (PubMed:24874917). No relevant cross-reactivity with Der p 5 allergen (PubMed:18445190, PubMed:29319884). No relevant cross-reactivity with Blot t 5 or Lep d 5 allergens. Causes histamine release from human peripheral blood mononuclear leukocytes. Up-regulates expression of CD203c activation marker on basophils. Induces degranulation of humanized rat basophil leukemia (RBL) cells and the release of beta-hexosaminidase from them (PubMed:18445190). Triggers interleukin-8 production in human airway epithelial cells through Toll-like receptor 2 (TLR2)-dependent signaling (PubMed:24874917) | |
| Causes an allergic reaction in human. Binds to IgE in 46% of 28 Penicillium-sensitized asthmatic patients from Taipei area | |
| Causes an allergic reaction in human. Natural protein binds to IgE in 32% and 40% of the 57 S.kali pollen-allergic patients tested from the center (Zaragoza) and east coast (Murcia) of Spain, respectively. IgE-binding is decreased when the disulfide bonds are disrupted | |
| Causes an allergic reaction in human. Binds to IgE in 47% of the 30 patients allergic to S.kali pollen | |
| Causes an allergic reaction in human. Binds to IgE in 54% of the 92 patients, including both Europeans and Americans, tested allergic to ragweed pollen. Purified native protein under non-denaturing conditions binds to IgE in 66% of the same 92 patients tested (PubMed:25865353). Binds to IgE of mice. In mice, the allergicity especially to the proteolytically active form of this protein leads to airway hyperresponsiveness, lung inflammation characterized by eosinophil and type 2 innate lymphoid cell (ILC2) infiltrates in bronchoalveolar lavages (BALs), and responses of the T-helper 2 (Th2) cells (PubMed:27129273). Causes activation of human basophils (PubMed:25865353) | |
| Causes an allergic reaction in human (PubMed:14555856, PubMed:18558706, PubMed:20362336, PubMed:24926808, PubMed:25766831, PubMed:27129138, PubMed:26769082, PubMed:27513566). Binds to IgE of patients allergic to cashew nuts (PubMed:14555856, PubMed:18558706, PubMed:20362336, PubMed:24926808, PubMed:25766831, PubMed:26769082, PubMed:27513566). Recombinant protein binds to IgE in 62% of the 21 patients tested (PubMed:14555856). Reduced IgE-binding following 50 mM sodium sulfite treatment at 100 degrees Celsius or by 5 mM dithiothreitol (DTT) (PubMed:24926808). IgE-binding is reduced by 35% with 5 mM sodium oleate treatment at 70 degrees Celsius for 60 min only if followed by an additional overnight incubation at 37 degrees Celsius (PubMed:25766831). Allergenicity is removed from the cashew apple juice concentrate by 5 kDa filtration (PubMed:18558706). Retains immunoreactivity for mouse monoclonal antibodies (mAbs) 4C3 and 4H9 after a variety of processing treatments including autoclaving, blanching, microwave heating, dry roasting, gamma-irradiation and pH (PubMed:18795784). Significantly reduced immunoreactivity for mouse mAb 4C3 by 2.5 mM sodium dodecyl sulfate (SDS) or 2% v/v reducing agent beta-mercaptoethanol (beta-ME) with heat (100 degrees Celsius for 10 min) treatments (PubMed:21138244). Exposure to extreme pH (1 or 13) and extreme heat treatments (autoclaving for 30 min or roasting at 200 degrees Celsius for 15 min) results in almost complete loss of binding to mouse mAb 4C3 (PubMed:18795784). Mouse mAb 2B5 recognizes a conformational epitope on the acidic chain of this protein, the recognition of which requires the association of the basic chain, but is independent of their post-translational cleavage. The antibody competes with patient IgE for binding to the epitope. The epitope is destroyed by physical (boiling) and chemical (0.5 M beta-ME, 10% SDS and 6 M urea) denturation (PubMed:20362336). Cashew allergic patients elicit responses to this protein by CD4(+) T cells with T-helper 2 (Th2) and Th2/T-helper 17 (Th17) phenotypes (PubMed:27129138) | |
| Can cause allergic reactions in humans. Binds to IgE. Partially heat-labile allergen that may cause both respiratory and food-allergy symptoms in patients with the bird-egg syndrome | |
| Causes an allergic reaction in human. Binds to IgE of patients with bronchial asthma (PubMed:10231324, PubMed:14510716, PubMed:18760997). Binds to IgE in 24% of the 41 patients tested (PubMed:14510716) | |
| Causes an allergic reaction in human. Binds to IgE in 36% of the 11 patients tested allergic to mollusk S.constricta | |
| Causes an allergic reaction in human. Causes maize pollen allergy | |
| Causes an allergic reaction in human. Binds to IgE. Induces histamine release from basophils of profilin-allergic patients | |
| Causes an allergic reaction in human. Binds to IgE. May promote colonization through cytotoxic activity and by causing inflammatory reactions involving IgE antibodies. Binds also to IgG | |
| Causes an allergic reaction in human. Binds to IgE in 8% of 92 Taipei area patients suffering from bronchial asthma | |
| Causes an allergic reaction in human. Causes cabbage allergy | |
| Causes an allergic reaction in human. Binds to IgE in 54% of the 26 patients tested allergic to guinea pigs. Causes degranulation of humanized rat basophil leukemia cells (RBL) and release of beta-hexosaminidase | |
| Causes an oral allergy syndrome (OAS) reaction in human and animals (PubMed:22749702, PubMed:26433527, PubMed:17441795). Binds to IgE and induces the release of histamine from leukocytes of allergic patients (PubMed:17441795). Binds to IgE from canine atopic dermatitis (CAD) sensitive dogs (PubMed:22749702) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to Chinese yam (PubMed:18303202, PubMed:29423371). Patients can be sensitized to this protein via an oral or inhalant route (PubMed:18303202). Thermal stable oral allergen, which can to trigger anaphylactic reaction and oral allergy syndrome even when consumed as cooked. Activates human basophils (PubMed:29423371) | |
| Causes an allergic reaction in human. Binds to IgE in 57% of 21 C.herbarum-allergic patients tested | |
| Causes an allergic reaction in human (PubMed:12417891, PubMed:14713921). Gly m 4 is the major soy allergen for patients allergic to birch pollen with soy allergy (PubMed:12417891, PubMed:14713921). Binds to IgE (PubMed:12417891, PubMed:14713921) | |
| Causes an allergic reaction in human (PubMed:27069539, PubMed:30894561). Binds to IgE in 29% of the 38 dust mite allergic children tested. 43% of the 98 dust mite allergic adults tested show a positive response to this protein by skin prick test (PubMed:27069539). Binds to IgE in all of the 24 D.farinae allergic patients tested. There is a positive correlation between the number of specific major epitope residues in this allergen and the specific IgE level of the atopic population. The higher the IgE level of the patient for this protein, the higher the number of recognized epitope residues in this allergen by the IgE of the individual out of the 38 determined surface-exposed epitopes tested (PubMed:30894561). Causes an allergic reaction in mice. Mice allergic to this protein display elevated specific IgE and IgG1, increased levels of interferon gamma and interleukin-4 as well as increased proliferation of the spleen cells, airway hyperresponsiveness, large quantity of exudates in the airway lumen and profound inflammatory cell infiltration in the lung tissue (PubMed:27069539) | |
| Causes an allergic reaction in human and animals (e.g. rats, mouse and piglets); the acidic subunit is particularly allergenic (PubMed:18996574, PubMed:24499064, PubMed:23426933). Binds to IgE of patients with severe allergic reactions (anaphylaxis) to soybean (PubMed:18996574). Allergy to soybean is most common for infants (usually appears at the age of three months) which frequently outgrow their soybean allergy by the age of two, but a severe soybean allergy can last a lifetime; various symptoms involve skin, gastrointestinal tract and respiratory tracts (PubMed:24499064). Damaged intestinal function in piglets is associated with glycinin-mediated perturbation of nuclear factor-kappa B (NF-kappaB), Jun N-terminal kinase (JNK) and p38 levels (PubMed:30139257). Juvenile Chinese mitten crabs (E.sinensis) supplemented with glycinin display impaired growth and altered intestinal health due to gut inflammation, reshaped community of gut microbiota and digestive dysfunction (PubMed:30300740). Ingredient processing methods to reduce soybean allergenicity but keeping its nutritional values have been developed, among them physical processing includes extrusion, high-pressure (>300 MPa), heating (between 70 and 90 degrees Celsius), roasting, chemical processing includes ethanol extraction (55-76 percent between 70 and 80 degrees Celsius), in vitro glycation (e.g. with xylose at 55 degrees Celsius) and enzymatic hydrolysis with pepsin and trypsin, and biological processing includes fermentation with A.oryzae, S.cerevisiae, L.lactic subsplactis, B.subtilis, B.lactic and L.plantarum (PubMed:24499064, PubMed:27620509). Resistant to hydrolysis by papain, alcalase, and fungal protease (PubMed:24499064) | |
| May cause an allergic reaction in human (PubMed:27086707). Binds to IgE of patients allergic to birch Bet v 1 (PubMed:27086707). Causes degranulation of basophils sensitized with IgE of patients allergic to birch Bet v 1 (PubMed:27086707) | |
| Causes an allergic reaction in horses. Binds to IgE of 19 horses from Switzerland suffering from insect bite hypersensitivity (IBH), a recurrent seasonal dermatitis of the horse, caused by bites of Culicoides (midge) and sometimes Simulium (black fly) species. Binds to IgE of all 18 healthy control horses from Switzerland exposed to the bites of these insects, and of 8 horses from Iceland which had not been exposed to Culicoides midges. There is no significant difference in IgE-binding between the three groups of horses. Does not induce sulfidoleukotriene (sLT) release from peripheral blood leukocytes (PBLs) in any of the 5 horses tested affected by IBH | |
| Causes an allergic reaction in human (PubMed:17182577, PubMed:19032234, PubMed:21489611). Recombinant protein binds to IgE in atopic eczema-suffering patients allergic to opportunistic skin-colonizing yeast M.sympodialis. Intermediate cross-reactivity is detected between the recombinant thioredoxin from M.sympodialis (Mala s 13) and recombinant form of this protein. Skin-prick test (SPT) and atopy patch test (APT) with 5 patients confirm cross-reactivity between the two proteins (PubMed:17182577). Recombinant protein binds to IgE of patients suffering from allergic bronchopulmonary aspergillosis (ABPA) and cross-reacts extensively with recombinant thioredoxin proteins from A.fumigatus (Asp f 28 and Asp f 29) and Mala s 13. Causes a positive skin reaction and induces proliferation of the human peripheral blood mononuclear cells in ABPA patients allergic to this protein. Acts as an IgE-binding self-antigen in ABPA patients allergic to fungal thioredoxin (PubMed:19032234). In atopic dermatitis (AD)-suffering patients allergic to M.sympodialis, a cross-reactivity between Mala s 13 and this protein can be detected in T-cells of the peripheral blood and skin. Keratinocytes stimulated by interferon (IFN)-alpha and tumor necrosis factor (TNF)-alpha release thioredoxin, which then becomes available for cross-reactivity with Mala s 13-specific T cells. The autoreactive T cells identified include T-helper 1 (Th1), T-helper 2 (Th2), T-helper 17 (Th17) and T-helper 22 (Th22) phenotypes. Skinhoming T cells autoreactive to this protein may be relevant for cutaneous inflammation in patients with AD (PubMed:21489611) | |
| Causes an allergic reaction in human. Major allergen of wheat flour responsible for baker's asthma | |
| Causes an allergic reaction in human. Binds to IgE (PubMed:9412580, PubMed:10756236). Shares common IgE-binding epitopes with allergen Cand b 2 of Candida boidinii (PubMed:9412580) | |
| Causes an allergic reaction in human. Binds to IgE. A.simplex is a fish parasite that, when accidentally ingested by humans, may cause allergic reactions in sensitized individuals | |
| Causes an allergic reaction in human. This is one of the major allergens of Japanese cedar pollen, the most common pollen allergen in Japan | |
| Causes an allergic reaction in human (PubMed:15233621, PubMed:19006093, PubMed:21563837, PubMed:22616776, PubMed:22812192, PubMed:34146442). Binds to IgE of patients allergic to hazelnuts (PubMed:15233621, PubMed:19006093, PubMed:21563837, PubMed:22616776, PubMed:22812192, PubMed:34146442). Natural glycosylated protein binds to IgE in 47% and recombinant (non-glycosylated) protein in 43-40% of the 65 tested adult patients from Switzerland and Germany (PubMed:15233621). Natural protein binds to IgE in 50% of the tested patients from Netherlands (PubMed:19006093). The IgE-binding of the natural protein can be decreased by glycation (Maillard reaction) of the protein at 60 and 145 (routine hazelnut roasting condition), but not at 37 degrees Celsius (PubMed:21563837). IgE-binding of the natural protein is also strongly reduced by autoclaving at 138 degrees Celsius for 15 or 30 minutes, but not by high pressure treatment alone (300 Mba, 400 Mba, 500 Mba and 600 Mba) (PubMed:22616776). Allerginicity to this protein in a birch-endemic region (Belgium) seems to be predominantly found in children with severe hazelnut allergy compared to adults or children with milder forms of hazelnut-allergy. Natural protein binds to IgE in 36%, 40% and 12.5% of the 22 preschool children, 10 schoolchildren and 8 adults tested, respectively, with systemic allergic reactions toward hazelnut. In a set of 40 patients (6 preschool children, 10 schoolchildren and 24 adults) having oral allergy symptoms, only 2 patients (of preschool age) show IgE-binding to this protein. Also, only 8% of the 24 hazelnut-allergic infants with atopic dermatitis tested show IgE reactivity to this protein (PubMed:22812192). Induces histamine release from human basophils (PubMed:15233621, PubMed:22812192). Both natural and recombinant proteins induce histamine release from human basophils in a similar manner indicating that the carbohydrate structures are not involved in IgE-binding (PubMed:15233621). Induces beta-hexosaminidase release from humanized rat basophilic leukemia (RBL) cells. Heating, with or without glucose, at 145 degrees Celsius increases the basophil degranulation capacity (PubMed:21563837) | |
| Causes an allergic reaction in human. Binds to IgE. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis | |
| Causes an allergic reaction in human. Natural protein binds to IgE of patients allergic to toxic black mold fungus (PubMed:21109751, PubMed:22424314). Recombinant protein binds to IgE of patients allergic to toxic black mold fungus (PubMed:21109751). Binds to IgG (PubMed:22424314) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to walnuts (PubMed:9648708, PubMed:25388987, PubMed:11799381, PubMed:19540419, PubMed:22042002, PubMed:27597723, PubMed:28552380, PubMed:31175720, PubMed:32283362). Binds to IgE of patients allergic to peanuts (PubMed:22042002). Binds to IgE in 97% of the 32 Korean babies and children tested allergic to walnuts (PubMed:31175720). Native protein binds to IgE in 100% of the 6 Chinese walnut-allergic patients tested (PubMed:32283362). Native protein binds to IgE in 45% of the 11 walnut-allergic patients tested living in Spain or England (PubMed:25388987). Recombinant protein binds to IgE in 75% of the 16 walnut-allergic patients tested (PubMed:9648708). Recombinant protein binds to IgE in 100% of the 20 walnut-allergic patients tested (PubMed:11799381). Recombinant protein binds to IgE in 55% and 61% of the 33 walnut-allergic adult patients living in Netherlands tested by ImmunoCAP and ImmunoCAP ISAC, respectively (PubMed:27597723). Contains linear and conformational IgE-binding epitopes (PubMed:11799381). Cross-reacts with sesame seed allergens Ses i 1 and Ses i 2. IgE-binding is lost in the presence of pepsin after 1 hour incubation at pH 1.5 and 37 degrees Celsius in vitro, but it is not affected in the presence of trypsin and chymotrypsin after 2 hour incubation in vitro at pH 8 and 37 degrees Celsius. Induces in vitro degranulation of the humanized rat basophilic leukemia (RBL) cells and release of beta-hexosaminidase from them (PubMed:19540419) | |
| Acts as a major allergen in patients suffering from extrinsic bronchial asthma. Binds to IgE | |
| Causes an allergic reaction in human. This is one of the major allergens of the ragweed pollen | |
| Causes an allergic reaction in human. Binds to IgE. Second most important allergen of C.herbarum in terms of frequency of sensitization | |
| Causes an allergic reaction in human. Involved in latex allergic reactions | |
| Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations | |
| May cause an allergic reaction in human (PubMed:11606193). Binds to IgE from patients allergic to pear fruit (PubMed:11606193). Induces histamine release from basophils of patient allergic to the pear fruit protein Pyr c 5 (PubMed:11606193). Exhibits cross-reactivity with IgE from patients allergic to other fruits, vegetables and birch pollen (PubMed:11606193). May be a minor allergen of pear fruit (PubMed:11606193) | |
| Causes an allergic reaction in human. In most vespids, Antigen 5 is a potent allergen. Pol s 5 is a variant with a much lower allergenicity. It has a reduced IgE response and anaphylactic activity | |
| Causes an allergic reaction in human (PubMed:11940078). Binds to IgE from sera of patients allergic to rubber latex (PubMed:11940078) | |
| Causes an allergic reaction in human. Natural protein binds to IgE in 54% of the 24 patients from the Western USA tested allergic to American house dust mite (HDM). Causes an allergic reaction in dog. Natural protein binds to IgE in 57% of the 21 dogs with atopic dermatitis tested allergic to American HDM. In the intradermal tests, the natural protein produces positive reactions in 37% of the 19 dogs with atopic dermatitis tested allergic to American HDM. Binds to IgE in 77% of the 35 dogs with putative atopic dermatitis tested allergic to American HDM | |
| Can cause allergic reactions in humans | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to sesame seeds (PubMed:17517107, PubMed:17556061). Recombinant protein binds to IgE in 58% of the 19 patients tested (PubMed:17517107). Recombinant protein binds strongly to IgE in 54% of the 24 patients tested (PubMed:17556061). Recombinant protein is able to activate basophils previously passively sensitized with sesame-allergic sera in 7 out of 11 patients (PubMed:17517107) | |
| Causes an allergic reaction in human. Binds to IgE in 7% of the 133 patients allergic to arthropods including shrimp, house fly, household insects, mosquito, cockroach, spider and mites. Induces histamine release from basophils that are passively sensitized with IgE from silverfish tropomyosin-allergic patient | |
| Causes an allergic reaction in human. Binds to IgE in 9.6% of 177 patients allergic to Arizona cypress pollen | |
| Causes an allergic reaction in human. Binds to IgE (PubMed:21518038, PubMed:12823123). Binds to IgE in 65% of the 26 patients tested allergic to guinea pigs (PubMed:21518038). Is a cause of guinea pig hair allergy (PubMed:12823123). Causes degranulation of humanized rat basophil leukemia cells (RBL) and release of beta-hexosaminidase (PubMed:21518038) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to walnuts (PubMed:10589017, PubMed:30054513, PubMed:21883278, PubMed:22042002, PubMed:25772597). Binds to IgE of patients allergic to peanuts (PubMed:21883278, PubMed:22042002). Recombinant protein binds to IgE in 60% of the 15 patients tested allergic to walnuts (PubMed:10589017). Natural protein binds to IgE in 67% of the 6 patients tested allergic to peanuts and/or walnuts (PubMed:21883278). Binds to IgE in 53% of the 17 patients tested allergic to walnuts. Provokes CD4(+) T-cell responses. The central memory CD4(+) T-cells are the most prevalent phenotype detected in the peripheral blood of the patients. T-helper 2 (Th2) cells are prominent among the terminal effector T-cells, but T-helper 17 (Th17) and Th2/Th17 cells are also detected (PubMed:25772597) | |
| Causes an allergic reaction in human. Has six major and 3 minor IgE-binding regions and 5 major and 1 minor IgG-binding regions. Is a cause of cow's milk allergy (CMA) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to peach and sensitized to cypress pollen | |
| Causes an allergic reaction in human. Binds to IgE of saffron pollen-sensitized patients | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to shellfish (mollusks and crustaceans) | |
| Causes an allergic reaction in human and animals (e.g. rats, mouse and piglets); the acidic subunit is particularly allergenic (PubMed:18996574, PubMed:24499064, PubMed:23426933, PubMed:30078589). Binds to IgE of patients with severe allergic reactions (anaphylaxis) to soybean (PubMed:18996574). Allergy to soybean is most common for infants (usually appears at the age of three months) which frequently outgrow their soybean allergy by the age of two, but a severe soybean allergy can last a lifetime; various symptoms involve skin, gastrointestinal tract and respiratory tracts (PubMed:24499064). Damaged intestinal function in piglets is associated with glycinin-mediated perturbation of nuclear factor-kappa B (NF-kappaB), Jun N-terminal kinase (JNK) and p38 levels (PubMed:30139257). Juvenile Chinese mitten crabs (E.sinensis) supplemented with glycinin display impaired growth and altered intestinal health due to gut inflammation, reshaped community of gut microbiota and digestive dysfunction (PubMed:30300740). Ingredient processing methods to reduce soybean allergenicity but keeping its nutritional values have been developed, among them physical processing includes extrusion, high-pressure (>300 MPa), heating (between 70 and 90 degrees Celsius), roasting, chemical processing includes ethanol extraction (55-76 percent between 70 and 80 degrees Celsius), in vitro glycation (e.g. with xylose at 55 degrees Celsius) and enzymatic hydrolysis with pepsin and trypsin, and biological processing includes fermentation with A.oryzae, S.cerevisiae, L.lactic subsplactis, B.subtilis, B.lactic and L.plantarum (PubMed:24499064, PubMed:27620509). Resistant to hydrolysis by papain, alcalase, and fungal protease (PubMed:24499064) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to almonds (Probable) | |
| Causes an allergic reaction in human (PubMed:34525424). Binds to IgE in 60% of 5 patients allergic to macadamia nut (PubMed:34525424). Binds to IgE in 25% of 8 macadamia nut sensitized but clinically tolerant patients (PubMed:34525424). Also weakly binds to IgE in 7% of the 14 patients tested, that are allergic to peanut and/or tree nut but tolerant and not-sensitized to macadamia nut (PubMed:34525424) | |
| Causes an allergic reaction in human. Binds to IgE in 29% of the 14 patients tested allergic to pine nuts | |
| Causes an allergenic reaction in human. Binds to IgE | |
| Causes an allergic reaction in human. Binds to IgE. This is a food allergen | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to almonds (PubMed:21720172, PubMed:23498967). Binds to IgE in 50% of the 18 patients tested. Treatment with denaturing agents, such as 6 M urea, reducing buffer or 10% SDS, have little effect on IgE-binding intensity in a subset of these patients (PubMed:21720172). The mouse IgG monoclonal antibody (mAb) 4C10 reacts with non-reduced, but not the reduced form of this protein, and competes with patient IgE-binding. The conformational binding site of the antibody on this protein is in close proximity with a subset (118-132, 145-159 and 281-295) of patient sequential IgE-binding epitopes suggesting that these regions may be highly immunogenic (PubMed:23498967) | |
| Causes an allergic reaction in human. Binds to IgE in patients allergic to fish parvalbumin | |
| Causes an allergic reaction in human. Binds to IgE. Activates basophils | |
| Causes an allergic reaction in human. Binds to IgE in 23% of the 61 patients tested allergic to Penicillium mold | |
| Causes an allergic reaction in human. Is the cause of the celiac disease, also known as celiac sprue or gluten-sensitive enteropathy | |
| Causes an allergic reaction in human; allergic reactions against this protein result from initial sensitization to the major allergen from birch pollen, Bet v 1 | |
| Causes an allergic reaction in human (PubMed:16776685, PubMed:23075813, PubMed:27548813). Recombinant protein binds to IgE in 63% of the 27 patients tested allergic to house dust mite (HDM) (PubMed:16776685). The recombinant protein has 38%, 16% and 3% prevalences of IgE-binding with titers equal or above 0.1 ng/ml, 0.84 ng/ml and 10 ng/ml, respectively, of the 37 adult patients tested living in Perth, Australia allergic to European HDM (PubMed:23075813). Recombinant protein binds to IgE in 10% of the 91 adult Austrian patients tested allergic to European HDM. Binds to IgE in 15% of both the 20 and 13 patients tested with respiratory (asthma and allergic rhinitis) or skin (atopic dermatitis) manifestations, respectively. Induces activation of human basophils (PubMed:27548813) | |
| Causes an allergic reaction in human. Pooled with Ara h 10 binds to IgE in 75% of the 4 peanut-allergic patients tested | |
| Causes an allergic reaction in human (PubMed:10224228, PubMed:30150373). Binds to IgE of sensitized grass pollen allergic patients (PubMed:10224228, PubMed:30150373). Triggers immediate hypersensitivity reactions by cross-linking receptor-bound IgE molecules on effector cells, and induces degranulation of basophils sensitized with IgE (PubMed:30150373). Recombinant protein induces basophil histamine release and immediate type skin reactions in sensitized allergic patients (PubMed:10224228) | |
| Causes an allergic reaction in human (By similarity). It exhibits some cross-reactivity with antibodies from mouse immunizated to other Hymenoptera phospholipases (PubMed:8828537) | |
| Causes an allergic reaction in human. Binds to IgE in 71% of the 17 patients tested allergic to crustaceans. IgE-binding activity increases in the 44-70 degrees Celsius temperature range, but is lost at 80 degrees Celsius and above. IgE-binding activity is reduced under alkaline conditions (pH 9.0-11.0), but is increased at acidic conditions (pH 1.0-3.0). Allergenicity is reduced after 1 hour pepsin-digestion in vitro. A 4-hour digestion by pancreatic enzymes in vitro has little effect on the allergenicity. No change in allergenicity after ultrasound treatment. Reduced allergenicity after 180 s of microwave treatment or after boiling. The reduction in allergenicity is correlated with the treatment duration | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to storage mite T.putrescentiae (PubMed:19339798, PubMed:20197679, PubMed:20683648). Binds to IgE in 58% of the 110 patients tested (PubMed:19339798). Binds to IgE in 50% of the 44 elderly patients (aged 70-90) tested (PubMed:20197679). Binds to IgE in 45% of the 22 young adult rhinitis patients tested allergic to mites (both T.putrescentiae and D.pteronyssinus). This protein might be a T.putrescentiae specific allergen since it cannot be absorbed by group 3 allergen (Der p 3) of D.pteronyssinus in the IgE immunoblot inhibition assay (PubMed:20683648). Is able to induce histamine release from human basophils (PubMed:19339798) | |
| Causes an allergic reaction in human. Binds to IgE from the serum of kiwi-allergic patients | |
| Causes an allergic reaction in horses (PubMed:20537727, PubMed:23891138). Binds to IgE in 35% of the 48 Icelandic horses living in Switzerland tested affected by insect bite hypersensitivity (IBH), a recurrent seasonal dermatitis of the horse, caused by bites of Culicoides (midge) and sometimes Simulium (black fly) species. Does not bind to IgE of 27 horses out of the 29 horses living in Switzerland (24 Icelandic, 2 Swiss Warmbloods and 2 Shetland ponies) tested unaffected by IBH. Clear immediate and late phase hypersensitivity reactions to this protein in IBH-affected horses are evident by intradermal skin test (IDT), whereas control horses unaffected by IBH do not develop relevant immediate hypersensitivity reactions (PubMed:20537727). Binds to IgE of 18% of the 167 horses living in Belgium tested affected by IBH. Binds to IgE of 6% of the 176 horses living in Belgium tested not affected by IBH (PubMed:23891138) | |
| Causes an allergic reaction in human. Associated with allergic bronchopulmonary aspergillosis | |
| Causes an allergic reaction in human (PubMed:18996574). Binds to IgE of patients with severe allergic reactions (anaphylaxis) to soybean (PubMed:18996574) | |
| Causes an allergic reaction in human. Pooled with Ara h 11 binds to IgE in 75% of the 4 peanut-allergic patients tested | |
| Causes an allergic reaction in human (Ref.1, PubMed:24308509). Binds to IgE (PubMed:24308509) | |
| Causes an allergic reaction in human. Food allergenic protein which binds IgE from sera of patients allergic to maize | |
| Causes an allergic reaction in human. Natural protein was found to bind to IgE of a patient who had been working with ribosome-inactivating proteins for two years in a research laboratory setting | |
| Causes an allergic reaction in human. Causes grass pollen allergy. Binds to IgE of patients who are allergic to P.pratense | |
| Causes an allergic reaction in human. Binds to IgE of patients suffering from bronchial asthma (PubMed:10231324, PubMed:11893850, PubMed:12602675, PubMed:15663570). Binds to IgE in 17% of the 212 asthmatic patients of different age (3 to 94 years old). The binding frequency and intensity to IgE increases significantly with age. Binds also to IgG and IgG4 (PubMed:12602675). Induces histamine release from basophils of asthmatic patients (PubMed:11893850). May contribute to asthma by damaging the barrier formed by the airway epithelium by cleaving the tight junction protein OCLN and stimulating the release of mediators, such as PGE2, CXCL8 and TGFB1, in human respiratory epithelial cells (PubMed:16436150) | |
| Causes an allergic reaction in human (PubMed:9774427, PubMed:9679856, PubMed:10231327, PubMed:14610495, PubMed:10482846, PubMed:10887324, PubMed:16433216, PubMed:18205857, PubMed:21284746). Involved (at least via the N-terminal chitin-binding hevein-like domain) in cross-reactions with natural rubber latex (latex-fruit allergy syndrome) (PubMed:9774427, PubMed:9679856, PubMed:10231327, PubMed:14610495, PubMed:10482846, PubMed:10887324, PubMed:16433216). Binds to IgE of patients allergic to avocado, chestnut and/or banana (PubMed:9679856, PubMed:10482846, PubMed:16433216, PubMed:21284746). Binds to IgE in 75% of the 20 patients tested allergic to latex (PubMed:9774427). Binds to IgE in 80% of the 15 patients tested allergic to avocado and latex (PubMed:10231327). Binds to IgE in 53% of the 92 and 38% of the 26 kiwifruit-allergic patients tested by ELISA and IgE immunodetection assays, respectively. Only 12% of the 25 kiwifruit-allergic patients tested are found positive by skin prick test (PubMed:18205857). Binds to IgE in 29% of the 51 pediatric patients tested allergic to banana (PubMed:21284746). IgE-binding is not abolished by digestion with artificial gastric juice or simulated gastric fluid (PubMed:10231327, PubMed:14610495). In vitro IgE-binding and in vivo allergenicity (skin prick test) is abolished by heating (PubMed:10887324). Induces degranulation of human basohphils and histamine release (PubMed:16433216) | |
| Causes an allergic reaction in human. Binds to IgE. The skin barrier with higher pH level in atopic eczema patients seems to provide an environment that can enhance the release of this allergen from M.sympodialis, which can contribute to the inflammation | |
| Causes an allergic reaction in human. Allergen from olive pollen | |
| Causes an allergic reaction in human. Binds to IgE of saffron pollen-sensitized patients. Important allergen in workers of saffron industry | |
| Causes an allergic reaction in human. Binds to IgE in 68% of the 19 patients tested allergic to house dust mite (HDM) | |
| Causes an allergic reaction in human. Binds to IgE. Elicit type I skin reactions in mould-sensitized individuals | |
| Causes an allergic reaction in human. Causes positive immediate skin tests in cockroach-allergic patients using as little as 3 pg of recombinant protein. Associated with asthma | |
| Causes an allergic reaction in human. Binds to IgE via three immunodominant epitopes localized at the C-terminal part | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to storage mite T.putrescentiae (PubMed:9492316, PubMed:20197679, PubMed:20683648). Binds to IgE in 53% of the 44 elderly patients (aged 70-90) tested (PubMed:20197679). Binds to IgE in 73% of the 22 young adult rhinitis patients tested allergic to mites (both T.putrescentiae and D.pteronyssinus) (PubMed:20683648). Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis (Probable) | |
| Causes an allergic reaction in human. Binds to IgE in patients allergic to the pollen of cedar tree (PubMed:10657673, PubMed:10969020, PubMed:18270658). Native protein binds to IgE in 43% of the 14 patients and in 33% of the 36 patients tested allergic to the pollen of mountain cedar or Japanese cedar, respectively (PubMed:10657673). Recombinant protein binds to IgE of patients allergic to mountain cedar pollen (PubMed:18270658) | |
| Causes an allergic reaction in human. Binds to IgE. Has a potent ability to release histamine from washed blood cells of the mite-allergic patients | |
| Causes an allergic reaction in human. Binds to IgE in approximately 4% of patients tested allergic to A.alternata | |
| Causes an allergic reaction in human. Minor allergen of bovine dander | |
| Causes an allergic reaction in human. Binds to IgE (Probable) | |
| Causes an allergic reaction in human. Potent allergen responsible for about 80% of anti-horse IgE antibody response in patients who are chronically exposed to horse allergens | |
| Causes an allergic reaction in human. Binds to IgE in 11% of the 46 patients tested allergic to storage mite T.putrescentiae. IgE reactivity is calcium-dependent. Addition of 10 mM CaCl(2) increases the intensity of IgE-binding approximately 2-fold in 4 sera out of 5 tested | |
| Causes an allergic reaction in human. Potent allergen of bovine dander | |
| Causes an allergic reaction in human (PubMed:12530543). Binds to IgE of mugwort pollen-sensitized patients (PubMed:12530543) | |
| Causes an allergic reaction in human. Binds to IgE. Major allergen responsible for anaphylactic reactions | |
| Causes an allergic reaction in human. Natural and recombinant protein binds to IgE of patients allergic to crabs (PubMed:9819304, PubMed:23393908). Recombinant protein binds to IgE in all 10 patients tested allergic to crustaceans. Cross-reacts with greasyback shrimp topomyosin allergen Met e 1.0101 and Chinese spiny lobster tropomyosin allergen Pan s 1 (PubMed:9819304). Cross-reacts with blue swimmer crab tropomyosin allergen Por p 1 (PubMed:23393908) | |
| Causes an allergic reaction in human (PubMed:34525424). Binds to IgE in all 5 patients allergic to macadamia nut (PubMed:34525424). Binds to IgE in 50% of 8 macadamia nut-sensitized but clinically tolerant patients, however only weak IgE binding is observed in 3 of these patients (PubMed:34525424). Also weakly binds to IgE in 7% of the 14 patients tested, that are allergic to peanut and/or tree nut but tolerant and not-sensitized to macadamia nut (PubMed:34525424) | |
| Causes an allergic reaction in human (PubMed:16088208, PubMed:19248220, PubMed:23902156). Binds to IgE of patients allergic to mold P.brevicompactum (PubMed:16088208). Binds to IgE in 73% of the 41 Penicillium-sensitive patients tested (PubMed:19248220). Binds to IgE in 87% of the 61 patients tested allergic to Penicillium mold (PubMed:23902156) | |
| Causes an allergic reaction in human. Is one of the causes of cow's milk allergy | |
| Causes an allergic reaction in human. Binds to IgE in 96% of the 23 patients tested with oral allergy symptoms and pollen allergy to watermelon. IgE-binding is lost by digestion with pepsin | |
| Causes an allergic reaction in human. Binds to IgE and IgG | |
| Causes an allergic reaction in human. Binds to IgE in 29% of the 165 Spanish patients tested allergic to S.kali and/or C.album pollen | |
| Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE in 74% of 374 house dust mite allergic patients from different countries | |
| Causes an allergic reaction in human. Binds to IgE (PubMed:22104604, PubMed:22515174, PubMed:23464525, PubMed:23464491, PubMed:29207604, PubMed:30728436). Binds to IgE in 61% of the 44 patients tested allergic to both dog and cat dander (PubMed:22104604). Binds to IgE in 38% of the 100 patients tested allergic to dog dander (PubMed:22515174). Binds to IgE in all 3 patients tested allergic to both dog and horse dander (PubMed:23464491). Binds to IgE in 56% of the 32 Chinese children tested allergic to dog (PubMed:29207604). Binds to IgE in 47% of the 38 patients tested allergic to dog dander (PubMed:30728436). Causes activation of human basophils (PubMed:22515174, PubMed:29207604) | |
| Causes an allergic reaction in human (PubMed:25860789, PubMed:22790944, PubMed:28342912). Pooled with Ara h 14 binds to IgE in 75% of the 4 peanut-allergic patients tested (PubMed:25860789). Binds to IgE in all of the 8 peanut-allergic patients tested (PubMed:22790944). Protein obtained from roasted peanuts pooled with Ara h 14 binds to IgE in 97% of the 35 patients with severe peanut-allergy tested, but does not bind to IgE from patients with only mild allergy to peanuts. IgE-binding to this protein obtained from raw peanuts is notably decreased or almost undetectable in patients with severe peanut-allergy. Induces degranulation of human basophils (PubMed:28342912) | |
| Causes an allergic reaction in human. Binds to IgE. Induces basophil activation from blood of S.kali pollen-sensitized patients | |
| Causes an allergic reaction in human (PubMed:3192865). It exhibits some cross-reactivity with IgE antibodies from patients sensitized to other Hymenoptera venoms (PubMed:15753912) | |
| Causes an allergic reaction in human. Recombinant protein binds to IgE in 6% of the 78 mold mite T.putrescentiae-allergic patients tested living in Seoul, Korea | |
| Causes an allergic reaction in human. Binds to IgE and induces histamine release from basophils of Pj-pollen-allergic subjects | |
| Causes an allergic reaction in human. Binds to IgE in 24% of the 165 Spanish patients tested allergic to S.kali and/or C.album pollen. Reduced (by approximately 35%) IgE-binding capacity compared to Sal k 4.03 in 86% of the patients who have positive IgE-binding to the three profilins, Sal k 4.02, Sal k 4.03 and Che a 2 | |
| The heterodimer causes an allergic reaction in human. Binds to IgE. It is speculated that the antigenic site is on the A chain | |
| Causes an allergic reaction in human. Binds to IgE in 100% of the 13 shrimp-allergic patients tested | |
| Causes an allergic reaction in human (PubMed:25700348). Binds to IgE of patients allergic to rubber latex (PubMed:25700348). Binds to IgE of patients allergic to fruits (PubMed:25700348). Associated to the latex-fruit syndrome, an hypersensitivity to latex developed by individuals who are allergic to consumed fruits (Probable) | |
| Causes an allergic reaction in human (PubMed:12842183, PubMed:16436146, Ref.4, Ref.5, Ref.6, PubMed:27041301). Binds to IgE in patients allergic to fish parvalbumin (PubMed:16436146, PubMed:27041301, Ref.4, Ref.6). Binds to IgE in 80% of 5 fish-allergic patients tested (PubMed:12842183). IgE reactivity linearly decreases with the increase in heating temperature (from 40 to 140 degrees Celsius). More than 50% reduction of allergenicity by heating at 80 degrees Celsius and almost complete loss of allergenicity by heating at 140 degrees Celsius (PubMed:27041301). IgE reactivity of 12 fish-allergic patients tested is significantly reduced (60-100% reduction) in the presence of EGTA as a result of Ca(2+) depletion (Ref.5) | |
| Causes an allergic reaction in human. Binds IgE in 50% of cherry-allergic patients | |
| Causes an allergic reaction in human. Natural protein was found to bind to IgE of three patients who had been working with ribosome-inactivating proteins for two to three years in a research laboratory setting | |
| Causes an allergic reaction in human. Binds IgE. Induces basophil activation | |
| Causes an allergic reaction in human. Binds to IgE of patients with bronchial asthma | |
| Causes an allergic reaction in human (PubMed:17182577, PubMed:19032234). Recombinant protein binds to IgE in atopic eczema-suffering patients allergic to M.sympodialis (PubMed:17182577). Recombinant protein binds to IgE in 50% of the 40 patients tested suffering from allergic bronchopulmonary aspergillosis (ABPA). Causes a positive skin reaction and induces proliferation of the human peripheral blood mononuclear cells in ABPA patients allergic to this protein (PubMed:19032234) | |
| Causes an oral allergy syndrome (OAS) reaction in human and animals (PubMed:17441795, PubMed:22749702, PubMed:26433527). Binds to IgE and induces the release of histamine from leukocytes of allergic patients (PubMed:17441795). Binds to IgE from canine atopic dermatitis (CAD) sensitive dogs (PubMed:22749702) | |
| May cause an allergic reaction in human (By similarity). Binds to IgE of patients allergic to strawberry (By similarity) | |
| Causes an allergic reaction in human (PubMed:25860789, PubMed:12144563). Pooled with Ara h 15 binds to IgE in 75% of the 4 peanut-allergic patients tested (PubMed:25860789). Binds to IgE in 36% of the 14 peanut allergic-patients tested, however two of these patients IgE bind only weakly. IgE-binding is increased in roasted peanuts compared to fresh peanuts (PubMed:12144563) | |
| Causes an allergic reaction in human. Binds to IgE of mugwort pollen-sensitized patients (PubMed:12475905, PubMed:14510717, PubMed:20696401, PubMed:29220102, PubMed:30155917). Binds to IgE in 78% of the 113 Chinese patients tested (PubMed:29220102). Binds to IgE in 81% of the 240 Chinese patients tested. The patients from Southwestern China have significantly lower frequency of sensitization and lower IgE levels against this protein than the patients from Northern China. Patients allergic to multiple Artemisia allergens, including Art v 1, Art v 3 and Art an 7, have a higher risk of developing allergic asthma (PubMed:30155917). Post-translational modifications might be important in the formation of epitopes recognized by IgE antibodies from allergic patients (PubMed:12475905) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to cockroach. Binds to IgE in 86% of the 7 sera tested that also bind Bla g 6.0201 isoallergen. Calcium depletion by 10 mM ethylene glycol bis(2-aminoethyl)tetraacetic acid (EGTA) does not significantly affect IgE-binding, but addition of 10 mM CaCl(2) after calcium depletion increases IgE-binding by approximately 2-fold | |
| Causes an allergic reaction in human. Binds to IgE in 47% of the 17 patients tested allergic to mold F.proliferatum | |
| Causes an allergic reaction in human (PubMed:16904802, PubMed:8939158, PubMed:17147442, PubMed:25530105). Binds to IgE of patients allergic to crustaceans (shrimp and crab) (PubMed:16904802). Binds to IgE of patients residing in Japan and China allergic to squid (PubMed:8939158, PubMed:17147442, PubMed:25530105). Binds to IgE of American patients allergic to shrimp (PubMed:8939158). The allergenicity of this protein is reduced significantly by its reaction of lysines with ribose during the Maillard reaction (glycation), and to a lesser extent by digestion with pepsin. On the other hand, modification of the lysine residues in this protein using 2,4,6-trinitrobenzenesulfonic acid (TNBS) has no effect on allergenicity (PubMed:17147442). Treatment by high hydrostatic pressure (HHP) reduces allergenicity (400 and 600 MPa more effectively than 200 MPa) (PubMed:25530105) | |
| Causes an allergic reaction in human. Shares common IgE-binding epitopes with allergen Asp f 3 of Aspergillus fumigatus | |
| Causes an allergic reaction in human. Binds to IgE in 19% of 357 patients allergic to pomegranate | |
| Causes an allergic reaction in human. Binds to IgE in all 4 patients tested allergic to crustaceans | |
| Causes an allergic reaction in human. Binds to IgE of Penicillium-sensitive patients | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to London plane tree pollen (PubMed:15208603, PubMed:17177673). Binds to IgE in 84% of the 26 patients tested (PubMed:15208603). Binds to IgE in 50% of the 26 patients tested (PubMed:17177673) | |
| Causes an allergic reaction in human. Binds to IgE in 86.5% of the 37 patients tested allergic to horsefly bites. Has some binding capacity to IgE of patients with V.magnifica wasp sting allergy | |
| Causes an allergic reaction in human. Binds to IgE in 45% of the 106 patients tested allergic to storage mite T.putrescentiae. The percentage decreases to about 18% when sera from these patients is first absorbed with D.pteronyssinus extract indicating high cross-reactivity between the corresponding allergens of the two mites. Induces histamine release from basophils | |
| Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE in patients allergic to house dust mite (HDM) (PubMed:7798547, PubMed:2794865, PubMed:18445190, PubMed:24874917, PubMed:29319884, PubMed:20534590). Recombinant protein binds to IgE in 52% of the 25 patients tested (PubMed:7798547). Recombinant protein binds to IgE in 31% of the 117 patients tested living in urban area in Austria allergic to European HDM (PubMed:18445190). Recombinant protein binds to IgE in 69% of the 96 patients tested living in Bangkok allergic to European HDM (PubMed:24874917). Recombinant protein of 34-132 binds to IgE in 35% of the 62 patients tested (PubMed:20534590). In the skin tests, the recombinant protein produces positive reactions in 67% of the 15 patients tested with asthma and allergic rhinitis, in 58% of the 13 patients tested with asthma alone and in 29% of the 17 patients tested with allergic rhinitis alone (PubMed:7798547). No relevant cross-reactivity with Der p 21 allergen (PubMed:29319884). Causes histamine release from human peripheral blood mononuclear leukocytes. Up-regulates expression of CD203c activation marker on basophils (PubMed:18445190) | |
| Causes an allergic reaction in human. Binds to IgE (Ref.1, PubMed:20564455). Binds to IgE in 100% of the 21 patients tested allergic to crustaceans (Ref.1). Allergenicity of this protein is reduced by pepsin or chymotrypsin, and most effectively by trypsin, digestion in vitro (PubMed:20564455) | |
| Causes an allergic reaction in human. Binds to IgE (PubMed:15208604). Exhibits a cross-reactivity with IgE from allergic patient to the Phleum pratense Phl p 7 allergen (PubMed:18250440) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to house dust mite | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to bed bugs (PubMed:16417223, PubMed:22305681). Binds to IgE in 30% of the 30 adult New York City (NYC) residents tested who had been bitten by the bed bug and had a visible response to it (an itchy raised bump) (PubMed:22305681) | |
| Causes an allergic reaction in human (Probable). Dimerization considerably increases the IgE-mediated degranulation in rat basophilic leukemia cells (PubMed:27586352) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to mountain cedar (PubMed:10482836, PubMed:10482835, PubMed:14563374, PubMed:16423400). Binds to IgE in 71% of the 14 patients tested allergic to mountain cedar. Binds to IgE in 40% of the 35 patients tested allergic to Japanese cedar (PubMed:10482835). IgE-binding is significantly reduced by heat denaturation (75 degrees Celsius), chemical denaturation (guanidine treatment) and reductive alkylation in guanidine, but not by reductive alkylation alone, indicating the presence of conformational epitopes. On the other hand, heat and guanidine-induced denaturation increases binding to a mouse monoclonal antibody KW-S91, indicative of enhanced display of the linear epitope by these treatments (PubMed:16423400). Causes proliferation of the peripheral blood mononuclear cells (PBMCs) in patients allergic to mountain cedar (PubMed:10482835). Causes seasonal allergic rhinitis in North America (PubMed:10482836, PubMed:10482835, PubMed:14563374, PubMed:16423400) | |
| Causes an allergic reaction in human. Binds to IgE of patients who are allergic to J.ashei | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to the pollen of grasses (PubMed:18817975, PubMed:21231976, PubMed:20962534, PubMed:22832594, PubMed:25612605). Natural protein binds to IgE in all 21 patients tested strongly allergic to Bahia grass pollen (BaGP). Recombinant protein binds to IgE in 85% of the 55 BaGP-allergic patients tested. Lack of glycosylation does not affect IgE-binding activity (PubMed:18817975). Natural protein binds to IgE in 91% of the 51 BaGP-allergic patients tested (PubMed:20962534). Natural protein reacts with monoclonal antibody against pollen allergen Lol p 1 (PubMed:18817975, PubMed:21231976, PubMed:20962534, PubMed:25612605). Both natural and recombinant protein can up-regulate CD63 expression on the surface of patients basophils (PubMed:18817975, PubMed:21231976). IgE of patients allergic to this protein cross-reacts with pollen allergens Lol p 1 and Cyn d 1 (PubMed:21231976, PubMed:22832594). At least one of the three immunodominant T cell epitopes evoke peripheral blood mononuclear cell (PBMC) proliferation in 83% of the 18 BaGP-allergic patients tested. T cell epitopes can also induce secretion of cytokines IL-4, IL-5, IL-10, IFN-gamma and TNF-alpha in BaGP-allergic patients, but do not bind IgE (PubMed:22832594) | |
| Causes an allergic reaction in human. Binds to IgE in 57% of 44 patients suffering from bronchial asthma | |
| Causes an allergic reaction in human. Involved in latex allergic reactions (PubMed:10955696). Dimerization considerably increases the IgE-mediated degranulation in rat basophilic leukemia cells (PubMed:27586352) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to mugwort pollen (PubMed:29220102, PubMed:30155917). The natural protein binds to IgE in 94% and 95% of the 113 Chinese and 20 Dutch patients tested, respectively. The natural protein gives a positive reaction in 50% of the 14 Chinese patients tested by intradermal skin testing. All except one of these positives are also positive by ImmunoCAP test. The recombinant protein binds to IgE in 4% and 50% of the 54 Chinese and 20 Dutch patients tested, respectively. The lack of IgE-binding to the recombinant protein is not due to the absence of cross-reactive carbohydrate determinants (CCD), although in a subset of (Dutch) sera CCD does seem to play a role in the IgE recognition (PubMed:29220102). Binds to IgE in 80% of the 240 Chinese patients tested. Adult group has a significantly lower IgE level than the child and teenager group. The patients from Southwestern China have significantly lower frequency of sensitization and lower IgE levels against this protein than the patients from Northern China. Patients allergic to multiple Artemisia allergens, including Art an 7, Art v 1 and Art v 3, have a higher risk of developing allergic asthma (PubMed:30155917) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to crabs (PubMed:30187588, PubMed:31668066). Binds to IgE in 23% of the 30 patients tested (PubMed:30187588). Binds to IgE in all 12 patients tested. Induces activation of human basophils (PubMed:31668066) | |
| Causes an allergic reaction in human (PubMed:34525424). Recombinant protein binds to IgE in 40% of 5 patients allergic to macadamia nut (PubMed:34525424). Binds to IgE in 38% of 8 macadamia nut sensitized but clinically tolerant patients, however only weak IgE binding is observed in 1 of these patients (PubMed:34525424). Also binds to IgE in 14% of the 14 patients tested, that are allergic to peanut and/or tree nut but tolerant and not-sensitized to macadamia nut (PubMed:34525424) | |
| Causes an allergic reaction in human. Natural and recombinant protein binds to IgE of patients allergic to toxic black mold fungus | |
| Causes an allergic reaction in human. Binds to IgE of crab-allergic patients (PubMed:23911402, PubMed:25728640, PubMed:30236721). Binds to IgE in 89% of the 9 patients tested allergic to crab (PubMed:23911402). Causes degranulation of rat basophilic leukemia (RBL) cells and release of beta-hexosaminidase from them. Allergenicity is affected to different degrees by denaturants. SDS reduces allergenicity at low concentrations (0.3 mM), and allergenicity is almost completely abolished with 15 mM SDS. Urea concentrations of 2.0-3.0 M enhance allergenicity, whereas at concentrations higher than 4.0 M, the allergenicity is reduced. Slight change in allergenicity after guanidinium chloride (GdnHCl) treatment, but when concentration of GdnHCl reaches 1.5 M, the allergenicity is unchanged. DTT (disulfide bond-reducing agent), at a concentration of 10 mM, causes a slight reduction in allergenicity and it is decreased in a dose-dependent manner at concentrations of 10-250 mM, but remains steady at higher concentrations. 2.5 M beta-mercaptoethanol (another disulfide bond-reducing agent) treatment reduces allergenicity (PubMed:25728640) | |
| May cause an allergic reaction in human (By similarity). Binds to IgE from sera of patients allergic to rubber latex (By similarity) | |
| Causes an allergic reaction in human. Recombinant protein binds to IgE in 57% of the 28 patients tested allergic to pecan nuts. Acidic chain is more immunoreactive than the basic chain | |
| Causes an allergic reaction in human. Allergen of horse dander | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to pecan nuts and walnuts. Binds to IgE in 30% of the 27 patients tested by Western blot and in 24% of the 25 patients tested by double-blind, placebo-controlled oral food challenge | |
| Causes an allergic reaction in human. Binds to IgE in 29% of 41 patients allergic to storage mite T.putrescentiae | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to hazelnuts (PubMed:14713920, PubMed:11898007, PubMed:19006093, PubMed:18036652, PubMed:22616776). IgE-binding of the natural protein is strongly reduced by autoclaving at 121 degrees Celsius for 15 or 30 minutes or at 138 degrees Celsius for 15 or 30 minutes, but not by high pressure treatment alone (300 Mba, 400 Mba, 500 Mba and 600 Mba) (PubMed:22616776) | |
| Causes an allergic reaction in human (PubMed:20061012, PubMed:21083775). Binds to IgE (PubMed:20061012, PubMed:21083775) | |
| Causes an allergic reaction in human. The Cor a 1 isoforms display different antigenic and allergenic properties | |
| Causes an allergic reaction in human (PubMed:27211622). Binds to IgE of patients allergic to pine nut (PubMed:27211622). Causes activation of basophils sensitized with IgE of patients allergic to pine nut (PubMed:27211622) | |
| Causes an allergic reaction in human. Binds to IgE and induces a strong histamine release | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to both the Indian jujube and latex (PubMed:16122801, PubMed:18435802, PubMed:22289730). Natural protein binds to IgE of patients allergic to the fruit of the Indian jujube. Recombinant protein binds to IgE in 87.5% of the 8 latex- and Indian jujube-allergic patients tested (PubMed:16122801). May stimulate allergic inflammation by inducing T-helper type 2 (Th2)-specific immune responses including increased production of cytokines, most predominantly IL13, from peripheral blood mononuclear cells (PBMC) of patients allergic to both latex and the fruit of the Indian jujube. Chitinase activity is required for this function (PubMed:22289730) | |
| Causes an allergic reaction in human. Causes maize pollen allergy (By similarity) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to crabs (PubMed:28692255, PubMed:30187588). Binds to IgE in 17% of 30 crab-allergic patients tested (PubMed:30187588). Binds to IgE in 100% of 22 patients tested allergic to crustaceans (crabs and/or shrimps) (PubMed:28692255). Activates basophils (PubMed:30187588) | |
| Causes an allergic reaction in human. Binds to IgE in 81% of the 16 patients sensitive to C.lunata. Induces histamine release from basophils | |
| Causes an allergic reaction in human (PubMed:34525424). Binds to IgE in 80% of 5 patients allergic to macadamia nut (PubMed:34525424). Binds to IgE in 25% of 8 macadamia nut sensitized but clinically tolerant patients (PubMed:34525424). Also weakly binds to IgE in 7% of the 14 patients tested, that are allergic to peanut and/or tree nut but tolerant and not-sensitized to macadamia nut (PubMed:34525424) | |
| Causes an allergic reaction in human. Avenins are one of the causes of celiac disease, also known as celiac sprue or gluten-sensitive enteropathy (By similarity) | |
| Causes an allergic reaction in human. Binds weakly to IgE in 38% of the 13 patients tested allergic to crustaceans (crayfish and shrimp) | |
| Causes an allergic reaction in human. Binds to IgE in 37% of the 19 patients tested allergic to pistachio and/or cashew. Cross-reacts with cashew allergen Ana o 1 | |
| Causes an allergic reaction in human. Binds to IgE in all 7 patients tested allergic to shrimp. The IgE-binding is not affected in the temperature range of 30 to 100 degrees Celsius, by acidic or alkaline pH or by pepsin digestion, but is reduced by 4-hour digestion with pancreatin. The conformational epitopes rather than the linear epitopes seem to be predominantly recognized by IgE | |
| This protein is similar to other pollen allergens but is truncated and lacks the IgE binding epitopes found in similar proteins so may not be allergenic | |
| Causes an allergic reaction in human. Binds to IgE in 100% of 15 patients tested allergic to periwinkle C.roseus pollen. Causes release of beta-hexosaminidase from rat basophil leukemia (RBL) cells | |
| Causes an allergic reaction in human and animals (e.g. rats, mouse and piglets); the acidic subunit is particularly allergenic (PubMed:18996574, PubMed:24499064, PubMed:23426933, PubMed:30078589). Binds to IgE of patients with severe allergic reactions (anaphylaxis) to soybean (PubMed:18996574). Allergy to soybean is most common for infants (usually appears at the age of three months) which frequently outgrow their soybean allergy by the age of two, but a severe soybean allergy can last a lifetime; various symptoms involve skin, gastrointestinal tract and respiratory tracts (PubMed:24499064). Damaged intestinal function in piglets is associated with glycinin-mediated perturbation of NF-kappa-B, Jun N-terminal kinase (JNK) and p38 levels (PubMed:30139257). Juvenile Chinese mitten crabs (E.sinensis) supplemented with glycinin display impaired growth and altered intestinal health due to gut inflammation, reshaped community of gut microbiota and digestive dysfunction (PubMed:30300740). Ingredient processing methods to reduce soybean allergenicity but keeping its nutritional values have been developed, among them physical processing includes extrusion, high-pressure (>300 MPa), heating (between 70 and 90 degrees Celsius), roasting, chemical processing includes ethanol extraction (55-76 percent between 70 and 80 degrees Celsius), in vitro glycation (e.g. with xylose at 55 degrees Celsius) and enzymatic hydrolysis with pepsin and trypsin, and biological processing includes fermentation with A.oryzae, S.cerevisiae, L.lactic subsplactis, B.subtilis, B.lactic and L.plantarum (PubMed:24499064, PubMed:27620509). Resistant to hydrolysis by papain, alcalase, and fungal protease (PubMed:24499064) | |
| Can cause allergic reactions in humans. Binds to IgE | |
| Causes an allergic reaction in human (PubMed:26897338). Binds to IgE (PubMed:20509661, PubMed:26897338) | |
| May cause an allergic reaction in human (PubMed:15507096, PubMed:16945416). Binds to IgE of patients allergic to strawberry, birch Bet v 1 and apple Mal d 1 (PubMed:15507096, PubMed:16945416). Causes degranulation of basophils sensitized with IgE of patients allergic to strawberry, birch Bet v 1 and apple Mal d 1 (PubMed:15507096) | |
| Causes an allergic reaction in human. Common symptoms of mite allergy are bronchial asthma, allergic rhinitis and conjunctivitis. Binds to IgE in 80% of patients with house dust allergy | |
| Major allergen that causes an allergic reaction in human. Binds to IgE and IgG | |
| Causes an allergic reaction in human. Impaired binding to IgE in immobilized assays such as immunoblots, indicating that its epitopes are modified, denatured or not accessible when it is bound to solid membranes. Soluble protein binds to IgE in inhibition assays. Induces beta-hexosaminidase release from humanized rat basophilic leukemia cells in 35% of the 17 carrot-allergic patients sera tested | |
| Causes an allergic reaction in human. A minor allergen. Binds to IgE from the serum of melon allergic patients | |
| Causes an allergic reaction in human. The native protein binds to IgE in all 31 patients tested allergic to Japanese cedar pollen | |
| Causes an allergic reaction in human. Recombinant protein binds to IgE in 62% of the 21 atopic eczema patients tested allergic to M.sympodialis | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to shrimp (PubMed:19523674, PubMed:20471069, PubMed:22192087). Natural boiled protein binds to IgE in 59.6% of the 52 shrimp-allergic patients tested. Recombinant protein binds to IgE in 64.5% of the 31 patients tested allergic to the natural protein. 85% of the patients binding the recombinant protein are children (PubMed:19523674). Epitope diversity and the frequency and intensity of IgE-binding is significantly more pronounced in children than in adults (PubMed:20471069). Patients (children or adults) with positive double-blind placebo-controlled food challenge (DBPCFC) to shrimp have a more frequent, intense and diverse recognition of the epitopes of this protein than those with negative challenge (PubMed:22192087). Recombinant protein activates rat basophilic leukemia (RBL) cells expressing human immunoglobulin epsilon Fc receptor type 1 and releases beta-hexosaminidase from the cells (PubMed:19523674) | |
| Causes an allergic reaction in human. Natural protein was found to bind to IgE of two patients who had been working with ribosome-inactivating proteins for two years in a research laboratory setting | |
| Causes an allergic reaction in human (PubMed:25860789, PubMed:12144563). Pooled with Ara h 15 binds to IgE in 75% of the 4 peanut-allergic patients tested (PubMed:25860789). Binds to IgE in 36% of the 14 peanut allergic-patients tested. IgE-binding is increased in roasted peanuts compared to fresh peanuts (PubMed:12144563) | |
| Causes an allergic reaction in human. Binds to IgE in 63% of 104 patients allergic to cypress pollen | |
| Causes an allergic reaction in human. Binds to IgE. The English plantain pollen is an important cause of pollinosis in the temperate regions of North America, Australia and Europe. The glycan moiety does not seem to constitute a relevant allergenic epitope | |
| Causes an allergic reaction in human (PubMed:22162266, PubMed:24198217). Binds to IgE of patients allergic to banana fruit (PubMed:22162266, PubMed:24198217). Induces basophil activation in blood sample of patient allergic to banana fruit (PubMed:22162266). Binds to IgE of patients allergic to rubber latex (PubMed:22162266). Associated to the latex-fruit syndrome, a hypersensitivity to some freshly consumed fruits developed by individuals who are allergic to natural rubber latex (Probable) | |
| Causes an allergic reaction in human (PubMed:20484919, PubMed:19295232, PubMed:12642849). Binds to IgE of patients allergic to melon (Cucumis melo) (PubMed:12642849). Binds to IgE of patients with oral allergy symptoms and pollen allergy to watermelon (PubMed:20484919, PubMed:19295232). Binds to IgE in 100% of the 17 patients tested (PubMed:20484919). Binds to IgE in 56% of the 23 patients tested. IgE-binding is lost by digestion with pepsin (PubMed:19295232). Induces degranulation of human basophils (PubMed:20484919) | |
| Causes an allergic reaction in humans. Binds to IgE | |
| Causes an allergic reaction in human. Recombinant protein binds to IgE in 100% of the 8 patients tested allergic to house dust mite (HDM). 50% of the 10 HDM-allergic patients tested have positive skin prick test (SPT) reactions to the recombinant protein | |
| Causes an allergic reaction in human (Probable) | |
| Causes an allergic reaction in human. Binds to IgE in 33% of the 12 patients tested allergic to octopus. IgE-binding activity can be significantly reduced with thermal, acidic or alkali treatment | |
| Causes an allergic reaction in human. Involved in latex allergic reactions. Major spina bifida (SB) associated latex allergen. Patients with SB are especially sensitive to specific allergens that do not usually affect adult patients without SB who are otherwise sensitive to latex. These patients are multioperated patients, whose mucosal membranes have been frequently in contact with latex products. Many patients with SB are sensitized to low molecular weight polypeptides derived from the fragmentation of Hev b 3 | |
| Causes an allergic reaction in human. Binds to IgE in 3% of 306 C.herbarum-allergic patients tested. Patients reactive to this protein seem to have a higher probability to suffer from asthma than other patients allergic to C.herbarum. Induces histamine release from human basophils | |
| Causes an allergic reaction in human (PubMed:24993820, PubMed:21912180). Binds to IgE in a patient bitten by Siberian hamster (PubMed:21912180). Binds to IgE in 100% of the 13 patients tested allergic to Siberian hamster. Causes degranulation of basophils (PubMed:24993820) | |
| Causes an allergic reaction in human. Causes immediate and delayed hypersensitivity skin reactions in man | |
| Causes an allergic reaction in human (PubMed:17182577, PubMed:19032234). Recombinant protein binds to IgE in atopic eczema-suffering patients allergic to yeast M.sympodialis (PubMed:17182577). Recombinant protein binds to IgE in 30% of the 40 patients tested suffering from allergic bronchopulmonary aspergillosis (ABPA). Causes a positive skin reaction and induces proliferation of the human peripheral blood mononuclear cells in ABPA patients allergic to this protein (PubMed:19032234) | |
| Major allergen that causes an allergic reaction in human. Binds to IgE | |
| Causes an allergic reaction in human. Recombinant protein binds to IgE in 41% of the 17 European wheat food-allergic patients tested. Six of these patients have a history of wheat-induced anaphylaxis. Estimation by logistic regression indicates a 24-fold higher probability of the relative risk of beta-amylase-reactive patients to develop a wheat-induced anaphylaxis. Induces degranulation of the humanized rat basophilic leukemia (RBL) cells and releases hexosaminidase from them | |
| Causes an allergic reaction in human (PubMed:12653800). Binds to IgE from sera of patients allergic to rubber latex (PubMed:12653800) | |
| Causes an allergic reaction in human. Pooled with Ara h 15 binds to IgE in 75% of the 4 peanut-allergic patients tested | |
| Causes an allergic reaction in human. Is the only allergen described until now in the olive fruit. Contains epitopes responsible of cross allergenicity between food and pollen allergenic thaumatin-like proteins (PubMed:27017426) | |
| May cause an allergic reaction in human (PubMed:9519865, PubMed:11606193, PubMed:10550744). Binds to IgE from patients allergic to birch pollen (PubMed:9519865, PubMed:11606193, PubMed:10550744). Induces histamine release from basophils of patient allergic to the birch pollen protein Bet v 6 (PubMed:10550744). Exhibits cross-reactivity with IgE from patients allergic to fruits and vegetables (PubMed:9519865, PubMed:11606193, PubMed:10550744). May be a minor allergen of birch pollen (PubMed:9519865, PubMed:11606193, PubMed:10550744) | |
| Causes an allergic reaction in human. Major allergen from olive pollen | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to Japanese buckwheat (PubMed:16549935, PubMed:12372998, PubMed:18520034, PubMed:20054125, PubMed:20407269, PubMed:21461893). Binds to IgE in 90% of the 10 patients tested having immediate hypersensitivity reactions (IRH) including anaphylaxis, but not to IgE from other 10 patients tested without IHR (PubMed:12372998). Natural protein binds to IgE in 76% of the 17 patients tested (PubMed:16549935). Recombinant protein binds to IgE in 83% of the 29 Japanese patients tested (PubMed:18520034). IgE-binding is unaffected by pepsin digestion (PubMed:12372998) | |
| Causes an allergic reaction in human. Binds to IgE (By similarity) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to Bermuda grass pollen (BGP) (PubMed:8828524, PubMed:16121337). Binds to IgE in all 18 patients tested (PubMed:8828524). Binds to IgE in 50% of the 10 patients tested (PubMed:16121337). Periodate oxidation decreases the binding activity to IgE from 20% to 65% as the concentration of periodate increases from 1 mmol/L to 10 mmol/L, indicating the involvement of the carbohydrate moiety of this protein in immune responses (PubMed:8828524). The fucosylated glycan structures of this protein can bind the human C-type lectin receptors CD209 (DC-SIGN) and its related receptor CLEC4M (L-SIGN). The interaction provokes an immune response leading to the activation of RAF1 and ERK kinases and to the induction of tumor necrosis factor (TNF)-alpha expression in human THP-1 cells and monocyte-derived dendritic cells (MDDCs) (PubMed:20080962) | |
| Causes an allergic reaction in human. Binds to IgE of patients allergic to sesame seeds (PubMed:12842185, PubMed:12110835, PubMed:15536424). Binds to IgE in 92% of the 24 patients tested (PubMed:12842185). Binds to IgE in 30% of the 20 patients tested (PubMed:12110835) | |
| Causes an allergic reaction in human (PubMed:17182577, PubMed:19032234). Recombinant protein binds to IgE in atopic eczema-suffering patients allergic to yeast M.sympodialis (PubMed:17182577). Recombinant protein binds to IgE in 50% of the 40 patients tested suffering from allergic bronchopulmonary aspergillosis (ABPA). Causes a positive skin reaction and induces proliferation of the human peripheral blood mononuclear cells in ABPA patients allergic to this protein (PubMed:19032234) | |
| Causes an allergic reaction in human. Binds to IgE (PubMed:12842183, PubMed:28479332). Binds to IgE in 80% of 5 fish-allergic patients tested (PubMed:12842183) | |
| Causes an allergic reaction in human. Binds to IgE. This is a pollen allergen | |
| Causes an allergic reaction in human. Binds to IgE in 92% of the 37 patients tested allergic to horsefly bites. Has some binding capacity to IgE of patients with V.magnifica wasp sting allergy | |
| Causes an allergic reaction in human (PubMed:11344362, PubMed:23397669). Binds to IgE (42% responsiveness) (PubMed:11344362, PubMed:23397669) | |
| Causes an allergic reaction in human (PubMed:12708986, PubMed:12752596). Recombinant protein binds to IgE in 51% of the 45 patients tested allergic to B.tropicalis mites (PubMed:12708986). Native protein binds to IgE in 57% of the 44 patients tested allergic to B.tropicalis mites (PubMed:12752596) | |
| Causes an allergic reaction in human. Involved in baker's asthma | |
| Causes an allergic reaction in human. Binds to IgE in patients allergic to the pollen of prickly saltwort. Both the recombinant 45 kDa N-terminal fragment and the 39 kDa C-terminal fragment of this protein bind to IgE in 67% of the 12 prickly saltwort pollen-allergic patients tested. The same patients have also a positive skin prick test (SPT) response toward these fragments | |
| Causes an allergic reaction in human. Binds to IgE and IgG(4) | |
| Causes an allergic reaction in human. Natural protein binds to IgE in 26% of the 77 walnut-allergic patients tested. IgE-binding is reduced by simulated gastric fluid and in vitro duodenal digestion, but not by heat treatment. Cross-reacts with its counterparts from hazelnut (Cor a 11), pistachio and sesame | |
| Causes an allergic reaction in humans. Binds to IgE of egg-allergic patients. Immunoreactivity is lost by simulated gastric and gastroduodenal digestion (PubMed:23122126). Binds to rabbit anti-ovomucoid IgG antibody indicating the cross-reactivity between this protein and the ovomucoid protein from egg white (PubMed:6838526) | |
| Causes an allergic reaction in human. Binds to IgE in 32% of 88 patients with cypress pollen sensitivity | |
| Causes an allergic reaction in human. Binds to IgE and IgG4. A.simplex is a fish parasite that, when accidentally ingested by humans, may cause allergic reactions in sensitized individuals | |
| Causes an allergic reaction in human. Binds to IgE in 81% of the 21 patients tested allergic to adult non-biting midge C.kiiensis | |
| Protein found in olive tree pollen that may cause an allergic reaction in human | |
| Causes an allergic reaction in human. Binds to IgE in 15.5% of 110 patients sensitized to C.herbarum | |
| Causes an allergic reaction in human (PubMed:18980324, PubMed:16717422, PubMed:15277744, PubMed:20431913, PubMed:21571740, PubMed:22449541). Natural protein binds to IgE in all 5 buckwheat-allergic patients tested. Natural protein is susceptible to digestion with pepsin, but resistant to digestion with trypsin. Recombinant protein binds to IgG of buckwheat-allergic patients (PubMed:22449541). Recombinant full-length protein (rTBt) binds to IgE of patients allergic to buckwheat (PubMed:18980324, PubMed:22449541). Recombinant N-terminal subunit (rTBb) binds to IgE of patients allergic to buckwheat (PubMed:21571740). Recombinant C-terminal subunit (rTBa) binds to IgE of patients allergic to buckwheat (PubMed:18980324, PubMed:16717422, PubMed:20431913). Natural 24 kDa protein binds to IgE of patients allergic to buckwheat (PubMed:15277744). Both the recombinant rTBb and rTBa have higher IgE-binding activity than rTBt (PubMed:18980324) | |
| Causes an allergic reaction in human. Recombinant protein binds to IgE in 93% of the 54 patients tested suffering with allergic bronchopulmonary aspergillosis (ABPA). Recombinant protein binds to IgE in 74% of the 35 A.fumigatus-allergic patients tested without ABPA | |