wanyu/IteraTeR_v2 huggingface dataset:
Original:  The US Food and Drug Administration created the "Critical Path Initiative" to enhance innovation of drug development, and the Breakthrough Therapy designation to expedite development and regulatory review of candidate drugs for which preliminary clinical evidence shows the drug candidate may substantially improve therapy for a serious disorder. . Additionally there is a strong emphasis of computational approaches and artificial intelligence
Revised:  The US Food and Drug Administration created the "Critical Path Initiative" to enhance innovation of drug development, and the Breakthrough Therapy designation to expedite development and regulatory review of candidate drugs for which preliminary clinical evidence shows the drug candidate may substantially improve therapy for a serious disorder. Additionally there is a strong emphasis of computational approaches and artificial intelligence
Edit intent: fluency
Original:   The process of defining characteristics of the drug does not stop once an NCE begins human clinical trials.
Revised:  The process of defining characteristics of the drug does not stop once an NCE is advanced into human clinical trials.
Edit intent: clarity
Original:  They must also test the compound for its potential to cause cancer (carcinogenicity testing).
Edit intent: coherence
Original:  If a  compound emerges from these tests with an acceptable toxicity and safety profile, and the company can further show it has the desired effect in clinical trials, then the NCE portfolio of evidence can be submitted for marketing approval in the various countries where the manufacturer plans to sell it.
Revised:  If a compound emerges from these tests with an acceptable toxicity and safety profile, and the manufacturer can further show it has the desired effect in clinical trials, then the NCE portfolio of evidence can be submitted for marketing approval in the various countries where the manufacturer plans to sell it.
Edit intent: clarity
Original:  Most NCEs fail during drug development, either because they have unacceptable toxicity or because they simply do not have the intended effect on the targeted disease  as shown in  clinical trials.
Revised:  Most novel drug candidates (NCEs) fail during drug development, either because they have unacceptable toxicity or because they simply do not have the intended effect on the targeted disease as shown in clinical trials.
Edit intent: clarity
Original:  Most NCEs fail during drug development, either because they have unacceptable toxicity or because they simply do not have the intended effect on the targeted disease  as shown in  clinical trials.
Revised:  Most NCEs fail during drug development, either because they have unacceptable toxicity or because they simply do not prove efficacy on the targeted disease as shown in clinical trials.
Edit intent: clarity
Original:  Most NCEs fail during drug development, either because they have unacceptable toxicity or because they simply do not have the intended effect on the targeted disease  as shown in  clinical trials.
Revised:  Most NCEs fail during drug development, either because they have unacceptable toxicity or because they simply do not have the intended effect on the targeted disease , as shown in clinical trials.
Edit intent: fluency
Original:  A median cost estimate of 2015-16 trials for development of 10 anti-cancer drugs was US $648 million.
Revised:  A median cost estimate of 2015–16 trials for development of 10 anti-cancer drugs was US $648 million.
Edit intent: clarity
Original:  A median cost estimate of 2015-16 trials for development of 10 anti-cancer drugs was US $648 million.
Revised:  A median cost estimate of 2015-16 trials for development of 10 anti-cancer drugs was $648 million.
Edit intent: clarity
Original:  But for companies that approved between eight and 13 drugs over 10 years , the cost per drug went as high as $5.5 billion, due mainly to  geographic expansion for marketing and ongoing costs for Phase IV trials and continuous monitoring for safety .
Revised:  But for companies that approved 8– 13 drugs over 10 years , the cost per drug went as high as $5.5 billion, due mainly to geographic expansion for marketing and ongoing costs for Phase IV trials and continuous monitoring for safety .
Edit intent: clarity
Original:  But for companies that approved between eight and 13 drugs over 10 years , the cost per drug went as high as $5.5 billion, due mainly to  geographic expansion for marketing and ongoing costs for Phase IV trials and continuous monitoring for safety .
Revised:  But for companies that approved between eight and 13 drugs , the cost per drug went as high as $5.5 billion, due mainly to geographic expansion for marketing and ongoing costs for Phase IV trials and continuous monitoring for safety .
Edit intent: clarity
Original:  But for companies that approved between eight and 13 drugs over 10 years , the cost per drug went as high as $5.5 billion, due mainly to  geographic expansion for marketing and ongoing costs for Phase IV trials and continuous monitoring for safety .
Revised:  But for companies that approved between eight and 13 drugs over 10 years , the cost per drug could rise to as high as $5.5 billion, due mainly to geographic expansion for marketing and ongoing costs for Phase IV trials and continuous monitoring for safety .
Edit intent: clarity
Original:  But for companies that approved between eight and 13 drugs over 10 years , the cost per drug went as high as $5.5 billion, due mainly to  geographic expansion for marketing and ongoing costs for Phase IV trials and continuous monitoring for safety .
Revised:  But for companies that approved between eight and 13 drugs over 10 years , the cost per drug went as high as $5.5 billion, due mainly to geographic expansion for marketing and ongoing costs for Phase IV trials for continuous safety surveillance .
Edit intent: clarity
Original: Many aspects of drug development focus on satisfying the regulatory requirements of drug licensing authorities .
Revised: Many aspects of drug development focus on satisfying the regulatory requirements for a new drug application .
Edit intent: clarity
Original:  Drug development commonly uses classical pharmacology, but more recently, reverse pharmacology (target based) is starting to be used.
Edit intent: coherence
Original:  These are typically set out as part of a museum's Collections Management Policy or CMP.
Revised:  These are typically set out as part of a museum's collections management policy or CMP.
Edit intent: fluency
Original:  These are typically set out as part of a museum's collections management policy or CMP.
Revised:  These are typically set out as part of a museum's collection management policy or CMP.
Edit intent: fluency
Original:  Ultimately the rebels were defeated with heavy losses, while the Americans and their Nicaraguan allies suffered very light URL  Beckett, I.F.W. (ed., 1988) The Roots of Counter-Insurgency, Blandford Press, London:
Revised:  Ultimately the rebels were defeated with heavy losses, while the Americans and their Nicaraguan allies suffered very light casualties. Beckett, I.F.W. (ed., 1988) The Roots of Counter-Insurgency, Blandford Press, London:
Edit intent: fluency
Original:  If they rupture, they allow air to escape into pleural space resulting in a spontaneous pneumothorax (Apical blebs are present in a high percentage of patients with primary spontaneous pneumothorax, and their rupture is thought to be the most frequent cause of spontaneous pneumothorax) .
Revised:  If they rupture, they allow air to escape into pleural space resulting in a spontaneous pneumothorax .
Edit intent: coherence
Original:  Blebs can form in a number of tissues due to different pathologies, including frostbitten tissues , and as a cause of spontaneous pneumothorax .
Revised:  Blebs can form in a number of tissues due to different pathologies, including frostbitten tissues .
Edit intent: coherence
Original:  The rebels then began collecting their dead and wounded and within another half hour the fighting had ceased.
Revised:  The rebels then began collecting their dead and wounded and within another half-hour the fighting had ceased.
Edit intent: fluency
Original: At about 1:00 am on September 19 , a force of around 200 rebel troops, loyal to Augusto César Sandino, attacked the small garrison of Telpaneca under the command of Marine First Lieutenant Herbert S. Keimling.
Revised: At about 1:00 am on the 19 , a force of around 200 rebel troops, loyal to Augusto César Sandino, attacked the small garrison of Telpaneca under the command of Marine First Lieutenant Herbert S. Keimling.
Edit intent: clarity
Original:  Museum helveticum, Volumes 34 à 35, B. Schwabe, 1977 This inscription was found in 1877 at Trier, Germany.
Revised:  This inscription was found in 1877 at Trier, Germany.
Edit intent: clarity
Original: An inscription records one Hariulfus, son of Hanhavaldus, of the royal family of the Burgundians (regalis gentis Burgundionum), who was already a protector domes ticus when he died at the age of twenty in the imperial court in Augusta TreverorumArnold Hugh Martin Jones, The later Roman Empire, 284-602:
Revised: An inscription records one Hariulfus, son of Hanhavaldus, of the royal family of the Burgundians (regalis gentis Burgundionum), who was already a protector domesticus when he died at the age of twenty in the imperial court in Augusta TreverorumArnold Hugh Martin Jones, The later Roman Empire, 284-602:
Edit intent: clarity
Original:  References External links The stele: URL
Revised:  References 
Edit intent: clarity
Original: The International Programme on the State of the Ocean (IPSO) focuses on the many factors that threaten the health of our oceans.
Revised: The International Programme on the State of the Ocean (IPSO) focuses on the many factors that threaten the health of Earth's oceans.
Edit intent: clarity
Original: Ranjan Mathai (born 1952) was a former Indian Foreign Secretary and Indian High Commissioner to the UK.
Revised: Ranjan Mathai (born 1952) is a former Indian Foreign Secretary and Indian High Commissioner to the UK.
Edit intent: fluency
Original:  Ranjan Mathai is a 1974 batch Indian Foreign Service Officer.
Edit intent: coherence
Original: The term Royal City denotes a privilege that some cities in Bohemia and Moravia enjoyed during the Middle Ages.
Revised: The term royal city denotes a privilege that some cities in Bohemia and Moravia enjoyed during the Middle Ages.
Edit intent: fluency
Original:  If the applicant purchased a home, or lived in te city for a logn time, or could prove good ancestry and a decent family life and, if he had been a subject, could show a release certificate, then the applicant had a chance to be admitted to this privileged class.
Revised:  If the applicant purchased a home, or lived in the city for a logn time, or could prove good ancestry and a decent family life and, if he had been a subject, could show a release certificate, then the applicant had a chance to be admitted to this privileged class.
Edit intent: fluency
Original:  If the applicant purchased a home, or lived in te city for a logn time, or could prove good ancestry and a decent family life and, if he had been a subject, could show a release certificate, then the applicant had a chance to be admitted to this privileged class.
Revised:  If the applicant purchased a home, or lived in te city for a long time, or could prove good ancestry and a decent family life and, if he had been a subject, could show a release certificate, then the applicant had a chance to be admitted to this privileged class.
Edit intent: fluency
Original:  If the applicant purchased a home, or lived in te city for a logn time, or could prove good ancestry and a decent family life and, if he had been a subject, could show a release certificate, then the applicant had a chance to be admitted to this privileged class.
Revised:  If the applicant purchased a home, or lived in te city for a logn time, or could prove "good" ancestry and a decent family life and, if he had been a subject, could show a release certificate, then the applicant had a chance to be admitted to this privileged class.
Edit intent: fluency
Original:  At the beginning of the 16th Century , about 40 cities enjoyed this privilege.
Revised:  At the beginning of the 16th century , about 40 cities enjoyed this privilege.
Edit intent: fluency
Original:  Another source of income for the king were cities with the status of (plural ), but these were not inalienable and had a lesser status.
Edit intent: coherence
Original:  vor 1224 Hradec Králové (Königgrätz) 1225 Znojmo (Znaim) 1226 Jemnice (Jamnitz) etwa 1227 Hodonín (Göding) etwa 1228 Litoměřice (Leitmeritz) 1228–1230 Bzenec (Bisenz) 1231 Staré Město (Prager Altstadt) 1235–1245 Brno (Brünn) 1238, 1240 Stříbro (Mies) 1240 Loket (Elbogen) 1240–1253 Žatec (Saaz) 30. November 1265 Přerov (Prerau) 1252 Olomouc (Ölmütz) 1253 Jihlava (Iglau) 1253 Písek (Pisek) 1256 Kolín (Kolin, also known as Cologne on the Elbe) 1253–1261 Kouřim (Gurim, older:
Revised:  vor 1224 Hradec Králové (Königgrätz) 1225 Znojmo (Znaim) 1226 Jemnice (Jamnitz) etwa 1227 Hodonín (Göding) etwa 1228 Litoměřice (Leitmeritz) 1228–1230 Bzenec (Bisenz) 1231 Staré Město (Prager Altstadt) 1235–1245 Brno (Brünn) 1238, 1240 Stříbro (Mies) 1240 Loket (Elbogen) 1240–1253 Žatec (Saaz) 1265 Přerov (Prerau) 1252 Olomouc (Ölmütz) 1253 Jihlava (Iglau) 1253 Písek (Pisek) 1256 Kolín (Kolin, also known as Cologne on the Elbe) 1253–1261 Kouřim (Gurim, older:
Edit intent: coherence
Original:  13. November 1257 Čáslav (Tschaslau)
Revised:  1257 Čáslav (Tschaslau)
Edit intent: clarity
Original:  1270 Uherský Brod (Ungarisch Brod) 1272  Nymburk (Nimburg, also known as Neuenburg on the Elbe) 1276 Tachov (Tachau) 1253–1278 Dvůr Králové (Königinhof on the Elbe) from 1253 to 1278 and after 1399 Jaroměř (Jermer) 1253–1278 Mělník (Melnik) 1253–1274 Kutná Hora (Kuttenberg) vor 1276 Plzeň (Pilsen) 1295 Nový Bydžov (Neubidschow) 1305–1325 Vodňany (Wodnian) 1337 Pražské Nové Město (Prager Neustadt) 1348 Karlovy Vary (Karlsbad) 14. August 1370 Trutnov (Trautenau) 1399 Sušice (Schüttenhofen) 1273?
Revised:  1270 Uherský Brod (Ungarisch Brod) 1272 Sušice (Schüttenhofen) 1273? Nymburk (Nimburg, also known as Neuenburg on the Elbe) 1276 Tachov (Tachau) 1253–1278 Dvůr Králové (Königinhof on the Elbe) from 1253 to 1278 and after 1399 Jaroměř (Jermer) 1253–1278 Mělník (Melnik) 1253–1274 Kutná Hora (Kuttenberg) vor 1276 Plzeň (Pilsen) 1295 Nový Bydžov (Neubidschow) 1305–1325 Vodňany (Wodnian) 1337 Pražské Nové Město (Prager Neustadt) 1348 Karlovy Vary (Karlsbad) 14. August 1370 Trutnov (Trautenau) 1399 Sušice (Schüttenhofen) 1273?
Edit intent: fluency
Original:  1270 Uherský Brod (Ungarisch Brod) 1272  Nymburk (Nimburg, also known as Neuenburg on the Elbe) 1276 Tachov (Tachau) 1253–1278 Dvůr Králové (Königinhof on the Elbe) from 1253 to 1278 and after 1399 Jaroměř (Jermer) 1253–1278 Mělník (Melnik) 1253–1274 Kutná Hora (Kuttenberg) vor 1276 Plzeň (Pilsen) 1295 Nový Bydžov (Neubidschow) 1305–1325 Vodňany (Wodnian) 1337 Pražské Nové Město (Prager Neustadt) 1348 Karlovy Vary (Karlsbad) 14. August 1370 Trutnov (Trautenau) 1399 Sušice (Schüttenhofen) 1273?
Revised:  1270 Uherský Brod (Ungarisch Brod) 1272 Nymburk (Nimburg, also known as Neuenburg on the Elbe) 1276 Dvůr Králové (Königinhof on the Elbe) from 1253 to 1278 and after 1399 Jaroměř (Jermer) 1253–1278 Mělník (Melnik) 1253–1274 Kutná Hora (Kuttenberg) vor 1276 Plzeň (Pilsen) 1295 Nový Bydžov (Neubidschow) 1305–1325 Vodňany (Wodnian) 1337 Pražské Nové Město (Prager Neustadt) 1348 Karlovy Vary (Karlsbad) 14. August 1370 Trutnov (Trautenau) 1399 Sušice (Schüttenhofen) 1273?
Edit intent: clarity
Original:  1270 Uherský Brod (Ungarisch Brod) 1272  Nymburk (Nimburg, also known as Neuenburg on the Elbe) 1276 Tachov (Tachau) 1253–1278 Dvůr Králové (Königinhof on the Elbe) from 1253 to 1278 and after 1399 Jaroměř (Jermer) 1253–1278 Mělník (Melnik) 1253–1274 Kutná Hora (Kuttenberg) vor 1276 Plzeň (Pilsen) 1295 Nový Bydžov (Neubidschow) 1305–1325 Vodňany (Wodnian) 1337 Pražské Nové Město (Prager Neustadt) 1348 Karlovy Vary (Karlsbad) 14. August 1370 Trutnov (Trautenau) 1399 Sušice (Schüttenhofen) 1273?
Revised:  1270 Uherský Brod (Ungarisch Brod) 1272 Nymburk (Nimburg, also known as Neuenburg on the Elbe) 1276 Tachov (Tachau) 1253–1278 Dvůr Králové (Königinhof on the Elbe) 1253 to 1278 and after 1399 Jaroměř (Jermer) 1253–1278 Mělník (Melnik) 1253–1274 Kutná Hora (Kuttenberg) vor 1276 Plzeň (Pilsen) 1295 Nový Bydžov (Neubidschow) 1305–1325 Vodňany (Wodnian) 1337 Pražské Nové Město (Prager Neustadt) 1348 Karlovy Vary (Karlsbad) 14. August 1370 Trutnov (Trautenau) 1399 Sušice (Schüttenhofen) 1273?
Edit intent: clarity
Original:  1270 Uherský Brod (Ungarisch Brod) 1272  Nymburk (Nimburg, also known as Neuenburg on the Elbe) 1276 Tachov (Tachau) 1253–1278 Dvůr Králové (Königinhof on the Elbe) from 1253 to 1278 and after 1399 Jaroměř (Jermer) 1253–1278 Mělník (Melnik) 1253–1274 Kutná Hora (Kuttenberg) vor 1276 Plzeň (Pilsen) 1295 Nový Bydžov (Neubidschow) 1305–1325 Vodňany (Wodnian) 1337 Pražské Nové Město (Prager Neustadt) 1348 Karlovy Vary (Karlsbad) 14. August 1370 Trutnov (Trautenau) 1399 Sušice (Schüttenhofen) 1273?
Revised:  1270 Uherský Brod (Ungarisch Brod) 1272 Nymburk (Nimburg, also known as Neuenburg on the Elbe) 1276 Tachov (Tachau) 1253–1278 Dvůr Králové (Königinhof on the Elbe) from 1253 – 1278 and after 1399 Jaroměř (Jermer) 1253–1278 Mělník (Melnik) 1253–1274 Kutná Hora (Kuttenberg) vor 1276 Plzeň (Pilsen) 1295 Nový Bydžov (Neubidschow) 1305–1325 Vodňany (Wodnian) 1337 Pražské Nové Město (Prager Neustadt) 1348 Karlovy Vary (Karlsbad) 14. August 1370 Trutnov (Trautenau) 1399 Sušice (Schüttenhofen) 1273?
Edit intent: clarity
Original:  On  13 May, at about 3:40 pm, Captain Hunter was leading his men through a ravine when they were attacked by an advance guard of rebels positioned on a hill next to the Bocaycito River which links up with the El Cua River.
Revised:  On the 13 May, at about 3:40 pm, Captain Hunter was leading his men through a ravine when they were attacked by an advance guard of rebels positioned on a hill next to the Bocaycito River which links up with the El Cua River.
Edit intent: fluency
Original:  The Sandinistas then commenced another attack, numbering at least seventy-five men , and in the fight Corporal William R. Williamson was hit with a bullet and killed.
Revised:  The Sandinistas then commenced another attack, numbering at least seventy-five guerrillas , and in the fight Corporal William R. Williamson was hit with a bullet and killed.
Edit intent: clarity
Original:  On  14 May, Second Lieutenant Earl S. Piper assumed command and he chose to retreat in order to evacuate the wounded.
Revised:  On the 14 May, Second Lieutenant Earl S. Piper assumed command and he chose to retreat in order to evacuate the wounded.
Edit intent: fluency
Original: Rowley, pg. 7 On  16 May, when the aircraft returned they confirmed that reinforcements were on their way and, on  17 May, they dropped additional medical supplies.
Revised: Rowley, pg. 7 On the 16 May, when the aircraft returned they confirmed that reinforcements were on their way and, on 17 May, they dropped additional medical supplies.
Edit intent: fluency
Original: Rowley, pg. 7 On  16 May, when the aircraft returned they confirmed that reinforcements were on their way and, on  17 May, they dropped additional medical supplies.
Revised: Rowley, pg. 7 On 16 May, when the aircraft returned they confirmed that reinforcements were on their way and, on the 17 May, they dropped additional medical supplies.
Edit intent: fluency
Original:   "Realizing that Capt.
Revised:  "Realizing that Captain
Edit intent: fluency
Original: Rowley, pg. 8 Hunter's remains were later reburied in the United States in 1929.
Revised: Rowley, page 8 Hunter's remains were later reburied in the United States in 1929.
Edit intent: fluency
Original:  Thus, he became a member of the Palatinate Provisional government in 1849.
Revised:  Thus, he became a member of the Palatinate Provisional Government in 1849.
Edit intent: fluency
Original:  After the Provisional Governmen was crushed by the Prussian counter-revolutionary authorities, Greiner fled to Switzerland and then to the United States of America .
Revised:  After the government was crushed by the Prussian counter-revolutionary authorities, Greiner fled to Switzerland and then to the United States of America .
Edit intent: clarity
Original:  After the Provisional Governmen was crushed by the Prussian counter-revolutionary authorities, Greiner fled to Switzerland and then to the United States of America .
Revised:  After the Provisional Governmen was crushed by the Prussian counter-revolutionary authorities, Greiner fled to Switzerland and then to the United States .
Edit intent: clarity
Original: Abelgelil Mostafa was the general coordinator of The Egyptian Movement for Change ''' (Kefaya) and he's still but after the 2011 Egyptian Revolution he joined the Justice Party (Egypt) as a founder URL
Revised: Abelgelil Mostafa was the general coordinator of The Egyptian Movement for Change (Kefaya) and he's still but after the 2011 Egyptian Revolution he joined the Justice Party (Egypt) as a founder URL
Edit intent: fluency
Original: Dr. Abdelgelil Mostafa is an Egyptian Cardiologist and a political activist.
Revised: Dr. Abdelgelil Mostafa is an Egyptian cardiologist and a political activist.
Edit intent: fluency
Original: Aftermath Augusto César Sandino, the rebel general who was known to over-exaggerate , claimed that his men won the battle after three hours of fighting.
Revised: Aftermath Augusto César Sandino, the rebel general who was known to exaggerate , claimed that his men won the battle after three hours of fighting.
Edit intent: clarity
Original:  Lt. Christian Schilt performed the first evacuation of wounded by air, when he maded ten missions to an improvised strip 200 feet long and 100 feet wide.
Revised:  Lt. Christian Schilt performed the first evacuation of wounded by air, when he made ten missions to an improvised strip 200 feet long and 100 feet wide.
Edit intent: fluency
Original:  Captain Livingston was in Jinotega and his orders were to leave on  19 December 1927, and meet with Richal's column, which was marching from Telpaneca, at Quilali.
Revised:  Captain Livingston was in Jinotega and his orders were to leave on the 19 December 1927, and meet with Richal's column, which was marching from Telpaneca, at Quilali.
Edit intent: fluency
Original:  After that Richal continued towards the rendezvous and, on  1 January 1928, another battle was fought, six miles northwest of Quilali.
Revised:  After that Richal continued towards the rendezvous and, on the 1 January 1928, another battle was fought, six miles northwest of Quilali.
Edit intent: fluency
Original:  Accordingly, two columns were dispatched on this mission, one under Captain Richard Livingston, composed of 115 men, and the second under First Lieutenant Meron A. Richal, composed of sixty-five men.
Revised:  Accordingly, two columns were dispatched on this mission, one under Captain Richard Livingston, composed of 115 men, and the second under First Lieutenant Merton A. Richal, composed of sixty-five men.
Edit intent: fluency
Original:  Captain Livingston was in Jinotega and his orders were to leave on the 19 December 1927, and meet with Richal's column, which was marching from Telpaneca, at Quilali.
Revised:  Captain Livingston was in Jinotega and his orders were to leave on 19 December 1927, and meet with Richal's column, which was marching from Telpaneca, at Quilali.
Edit intent: fluency
Original:  While just 1,500 yards south of Quilali, he was attacked by approximately 200 Sandinistas well concealed behind rocks and foliage.
Revised:  While just south of Quilali, he was attacked by approximately 200 Sandinistas well concealed behind rocks and foliage.
Edit intent: clarity
Original:  After an eighty-minute battle the rebels retreated, though they managed to kill five Marines and two of the guards , twenty-three others were wounded.
Revised:  After an eighty-minute battle the rebels retreated, though they managed to kill five Marines and two of the guards ; twenty-three others were wounded.
Edit intent: fluency