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tomekkorbak

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pii-pile-chunk3-400000-450000

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[ "TLR-3 enhances osteoclastogenesis through upregulation of RANKL expression from fibroblast-like synoviocytes in patients with rheumatoid arthritis.", "\nThis study was undertaken to determine the effect of toll-like receptor-3 (TLR3) on the regulation of osteoclastogenic activity in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). ", "The expression of receptor activator of nuclear factor kappa B ligand (RANKL) mRNA and protein in RA-FLS after TLR3 activation was determined using RT-PCR, real-time PCR, western blot analysis, and immunohistochemistry. ", "Human monocytes were cocultured with RA-FLS that had been prestimulated by the TLR3 ligand polyriboinosinic-polyribocytidylic acid and then stained for tartrate-resistant acid phosphatase (TRAP) activity. ", "Other markers of osteoclasts were measured using RT-PCR and real-time PCR. ", "The expression of TLR3 and RANKL was much higher in the RA synovium than in the osteoarthritis (OA) synovium. ", "TLR3 activation induced RANKL expression in RA-FLS, but not in OA-FLS or in normal skin fibroblasts. ", "TLR3 activation also induced the production of IL-1beta but had no effect on IL-17 or TNF-alpha production in RA-FLS. ", "Inhibition of IL-1beta reversed the TLR3-induced upregulation of RANKL expression. ", "Coculture of human monocytes with TLR3-activated RA-FLS or TLR3 ligand-stimulated human monocytes increased the expression of TRAP, RANK, cathepsin K, calcitonin receptor, and MMP-9, reflecting the differentiation of monocytes into osteoclasts. ", "Our results suggest that TLR3 promotes osteoclastogenesis in the RA synovium both directly and indirectly. ", "TLR3 stimulates human monocytes directly to promote osteoclast differentiation. ", "TLR3 induces RANKL expression indirectly in RA-FLS, and the expression of RANKL promotes the differentiation of osteoclasts in the RA synovium. ", "Targeting the TLR3 pathway may be a promising approach to preventing inflammatory bone destruction in RA." ]

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[ "Q:\n\nHow to calculate difference between two values in two different rows\n\nI have some tables in postgresql database with historical data such as following sample: \n log_id | login_time | logout_time \n----------+---------------------+---------------------\n12885913 | 2016-03-01 05:10:59 | 2016-03-01 09:40:46\n12886931 | 2016-03-01 09:41:51 | 2016-03-01 12:44:49\n12887276 | 2016-03-01 12:45:54 | 2016-03-01 13:42:18\n\nI want to calculate difference between logout_time of each row with next login_time and save it as login time interval. ", "This table is result of python script that connect to postgresql 9.1 and extract these data from other tables and I want to find a solution with python for this issue.", "\n\nA:\n\nYou can use window function:\ncreate table log_times (\n log_id int,\n login_time timestamp,\n logout_time timestamp\n);\n\ninsert into log_times (log_id, login_time, logout_time) \nvalues \n(12885913, '2016-03-01 05:10:59', '2016-03-01 09:40:46'),\n(12886931, '2016-03-01 09:41:51', '2016-03-01 12:44:49'),\n(12887276, '2016-03-01 12:45:54', '2016-03-01 13:42:18')\n;\n\nselect \n *, \n login_time - lag(logout_time) over (order by log_id) \nfrom log_times;\n\nResult: \n log_id | login_time | logout_time | ?", "column? ", "\n----------+---------------------+---------------------+----------\n 12885913 | 2016-03-01 05:10:59 | 2016-03-01 09:40:46 | \n 12886931 | 2016-03-01 09:41:51 | 2016-03-01 12:44:49 | 00:01:05\n 12887276 | 2016-03-01 12:45:54 | 2016-03-01 13:42:18 | 00:01:05\n(3 rows)\n\n" ]

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[ "A Little Site to Brighten The Day\n\nMenu\n\nTag Archives: procrastination\n\n(All my posts are just for fun. ", "If I talk about something medical, ignore it. ", "Never take my advice on anything. ", "Truly.)", "\n\nEveryone has trouble focusing. ", "We live in a world where there are numerous interesting things to do, and it only takes seconds to get access to those interesting things. ", "As a chronic multitasker myself, I am completely guilty of separating my focus onto three different tasks at once. ", "For example, the other morning I found myself reading, watching television, and answering texts messages at one time. ", "I should probably have been ashamed, but I wasn’t. ", "In fact, I was proud of myself. ", "Here I was, maximizing my time, using different gadgets, and keeping in touch with my family and friends.", "\n\nThe truth of the matter is, we can’t really focus on that many activities at once. ", "The television show I was watching, I had seen hundreds of times before, and the messages I was writing didn’t require much effort. ", "You could say I was only really soaking in the book.", "\n\nBeing a graduate student has affected me strangely. ", "Some mornings I get up, drink a cup of coffee, and immediately get to work. ", "Other mornings, I sleep until 12 PM, go for a two hour walk, clean my house, and never once think about my thesis. (", "For all of you writing your dissertations, trust me, I understand that I have no right to bitch. ", "But here we are.). ", "It is infuriating, and I am scared every day that I won’t ever graduate or get my writing over with. ", "My focus goes from place to place, and I never really seem to be able to grasp what I am trying to accomplish at any given point.", "\n\nThere are a couple of extreme measures I take to sit down and truly focus:\n\n1. ", "Throw my phone away. ", "Or put it in another room. ", "Whatever it is, I get rid of it. ", "There are too many cool things on my phone: games, social media, good conversations, books, comics, and music. ", "If anything is going to draw my focus away, it will be my phone.", "\n\n2. ", "Lock myself in the most boring room I can find. ", "Honestly, this is usually some place in the library, or (no one tell my advisor) the archaeology lab in the evening. ", "Unless there are people in the lab, in which case I hightail it away from there.", "\n\n3. ", "Never open an internet browser unless it is connected to JSTOR, some peer reviewed journal, or the thesaurus. ", "NEVER.", "\n\n4. ", "If you take ADD medication, don’t skip that day. ", "If you don’t take ADD medication, start taking it now.", "\n\n5. ", "Find something that relaxes you, yet keeps you productive. ", "I have two go-tos. ", "Incense and tea. ", "I know, you all think I’m a useless hippie. ", "But if your relaxing agent is saying “bro” out loud to yourself or chugging a 40 of Coors, go for it.", "\n\n6. ", "Don’t underestimate the power of taking a ten minute break. ", "As long as you come back to what you were doing before, your mind can re-set itself, and give you a more long-term spurt of productivity.", "\n\n7. ", "Ignore your pets. ", "This sounds cruel, but here’s how it goes in my house. ", "I will be sitting around, playing on the computer all day. ", "Or reading a book for fun. ", "My cats will ignore me during this time- they will sleep or play with each other or run up and down the hallways. ", "But the minute I bring up a Word document, they decide it’s time to get in my lap and be incredibly cute. ", "And then I have to make the decision: do I pet them and immediately ruin my day of productivity? ", "Or do I look into their sweet little eyes, pick them up, and throw them onto the floor? ", "Damn them. ", "Damn them to hell.", "\n\n8. ", "If you are having relationship problems (and I know you all are, so don’t act like this isn’t a thing) stop thinking about them for five fucking seconds. ", "Jesus, as if you weren’t defined by more than just your pretty face and your inability to communicate with your partner.", "\n\n9. ", "Try to be excited about your work. ", "Again, this sounds like a given, but there are times where I immediately sabotage myself because I am tired of what I am doing. ", "Or I don’t see the point. ", "Don’t feel bad about having those doubts, but try to remind yourself why you were drawn to the subject in the first place. ", "How did you feel at the beginning of your project? (", "I know you had a schedule at the beginning of your project. ", "How did that go……)\n\nI did put up a points update. ", "This week, though, I’ve been visiting my grandmother in Charlottesville, VA and really didn’t do much except go to fancy dinners with my family and shop around with my mom for Israel stuff. ", "I did a lot of reading in the car trips there and back, but still haven’t finished anything.", "\n\nAlso the boy and I are starting our own YA fiction series; I think we are going for a sci-fi genre. ", "Finding the time to write creatively is going to be a struggle, especially since I am leaving the country for three weeks and he works about 90 hours a week. ", "And once August rolls around, I will be slammed with schoolwork, projects, and just trying to survive. ", "I think balance in life can be hard, and, speaking personally, I have a tough time knowing whether I like being busy or being lazy. ", "When I’m lazy, I crave challenge. ", "And when I’m incredibly busy, I crave an hour surfing the internet, watching television, or reading for fun.", "\n\nIt’s no secret that The Sunny Drug Corporation is sort of a description of my personality. ", "I struggle with being happy on a regular basis, so I create goals to feel as if I am constantly achieving something. ", "My therapist (yeah I’m admitting that) tells me that my goals are unachievable and I need to concentrate on the little goals. ", "I think my points system is helping me do that. ", "Instead of wanting to lose fifty pounds in like three weeks, I’m just working on exercising for an hour.", "\n\nAnd sometimes I don’t like to admit my true goals. ", "For example, I’d like to be classier (but with my cursing mouth I don’t know how possible that is). ", "And I’d like to make more money. ", "The last one I definitely don’t like to admit out loud, because it goes against my true beliefs. ", "I don’t think we should rely on money for happiness. ", "I don’t think money should be the ultimate indicator of success. ", "But……being able to pay my bills and get a little something extra now and again would be great.", "\n\nI’m going to find another way to make money, be classier, and honestly….just be happy." ]

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[ "Welcome To Instyle Fashion : Tailor Measurement\n\nEvery aspect of your garment will be cut and tailored uniquely to your personal 'pattern' to\nensure you look your best and feel totally comfortable and confident whatever the occasion.", "\nYou may provide us your measurements either by:\n\nAsking a friend to help measure you (you'll find instructions of how to take\nmeasurements accurately below).", "\n\nMeasuring your best-fitting suit or shirt (click here for instructions on how to take these\nmeasurements).", "\n\nor by Sending us your best-fitting suit or shirt by mail for us to copy. ", "These garments will\nbe returned to you along with your finished order. ", "You can send your best-fitting suit or\nshirt using the following address:\n92/7-8 Thaweewoong RD Soi Sea Beach Phuket 83150 Thailand\n\nNeck :\n\nMeasuring tape should be placed around neck where the\ncentre of the collar would be if you were wearing a shirt, just\nbelow the adams apple so that it is snug but not too tight.", "\n\nChest:\n\nStand relaxed with your hands down by your side.", "\nThe measuring tape should be placed around your body over\nyour shirt, close up under your arms and across your shoulder\nblades. ", "Tape should be held firm against the body but not too\ntight.", "\n\nWaist :\n\nThe measuring tape should be placed around the waist over\nthe shirt holding the tape firm against body, but not too tight.", "\n\nHips :\n\nMake sure to empty your pockets before taking this\nmeasurement. ", "Tape should be placed around the fullest part\nof the hips over the trouser seat and held firm against the\nbody but not too tight.", "\n\nFull Shoulder :\n\nPut on a shirt that is a comfortable fit.", "\nTake your full shoulder measurement from where the seam\non the sleeve joins the back left side to where the seam on\nthe sleeve joins the back right side.", "\n\nLength :\n\nThe tape should be held at the front of the body, with the\ntop of the tape placed on the shoulder seam.", "\nMeasurement should be taken from 1 inch (2.5cm) above\nthe tip of the thumb.", "\n\nSleeves :\n\nWith arm straight and hand in a loose fist, tape should be\nplaced at the shoulder seam and measurement taken from\nthe knuckle of the little finger less 1 ½ inches (3.75cm).", "\n\nCuff:\n\nMeasure the actual wrist size. ", "If you wear a medium size\nwatch add a ¼\" to that wrist for heavier watches add ½\"." ]

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[ "Puigdemont announced on Tuesday that his intention is to declare independence and enforce it because for him, the October 1 referendum results are valid and binding. ", "However, in his speech in Parliament, he suspended temporarily independence in favor of opening a period for dialogue with Spain. ", "The day after the speech, the Spanish government responded to the calls for dialogue by saying that they will not accept being involved in any mediation. ", "Besides, the Spanish president, Mariano Rajoy, opened the door to applying article 155 of the Spanish Constitution to Catalonia. ", "This would effectively suspend its self-rule.", "\n\nThe Catalan government is under pressure. ", "Not only from Spain, which is warning that it could suspend Catalonia’s self-government if independence is enforced. ", "But also from some pro-independence movements, which are pushing for just the opposite. ", "They are eager to see the suspension to the independence declaration lifted. ", "The Catalan president, Carles Puigdemont, is between a rock and a hard place.", "\n\n\"If they intend to continue applying article 155 and want to continue threatening and silencing us, they have to do it with the republic declared\"\n\nDeadline ends on Monday 16\n\nRajoy has given until next Monday for the Catalan government to clarify whether Puigdemont did declare independence, even if he suspended it immediately afterwards. ", "If he answers with anything that it is not a clear no or fails to reply entirely, Madrid will take full control of Catalonia’s autonomy. ", "While Puigdemont’s cabinet has not answered yet, the far-left CUP party urged him to reply that he did indeed declare independence on Tuesday.", "\n\nCUP party pushing to declare “the republic”\n\n“If they intend to continue applying article 155 and want to continue threatening and silencing us, they have to do it with the republic declared,” said the CUP party in a letter to the Catalan cabinet on Friday. “", "Only by a declaration of the republic will we be respecting what the majority expressed in the vote,” added the statement.", "\n\nThe main pro-independence civil organization, Catalan National Assembly (ANC in Catalan), called the government to lift the suspension of the declaration of independence announced by Puigdemont on Tuesday. ", "According to ANC, “it makes no sense” keeping the declaration on hold because of the “refusal of the Spanish government to any dialogue proposal”." ]

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[ "Languages of Guyana\n\nEnglish is the official language of Guyana, which is the only South American country with English as the official language.", "\n\nGuyanese Creole (an English-based creole with African and East Indian syntax) is widely spoken in Guyana.", "\n\nA number of Amerindian languages are also spoken by a minority of the population. ", " These include Cariban languages such as Macushi, Akawaio and Wai-Wai; and Arawakan languages such as Arawak (or Lokono) and Wapishana.", "\n\nSecond and third languages \n\nDue to the growing presence of Cubans and Venezuelans in the country, Spanish is heard more and more frequently, especially in Georgetown and Region 1. ", "Portuguese is increasingly being used as a second language in Guyana, particularly in the south of the country, bordering on Brazil. ", "Spanish, Portuguese and French are taught in most secondary schools.", "\n\nReferences\n\nExternal links \n Ethnologue list (map)" ]

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[ "Guam Highway 2\n\nGuam Highway 2 is one of the primary automobile routes in the United States territory of Guam.", "\n\nRoute description\nThe route runs in a south to north direction, from the Magellan Monument in the southern community of Umatac in a general northward direction to the community of Santa Rita, where it meets Highway 2A (which connects to Guam Highway 1 Marine Corps Drive) and Gate 2 of Naval Base Guam.", "\n\nMajor intersections\n\nSuffixed route\n\nGuam Highway 2A (GH-2A) connects GH-2 to GH-1 in Santa Rita, junctioning with GH-5 along the way.", "\n\nReferences\n\n002" ]

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[ "\"A favorite son\" is a retelling of a well-known Biblical tale of Jacob and Esau, their mother Rebecca, and Isaac, son of Abraham.", "\n\nEsav and Yankle, in this version, are twins who are born after their mother, Becky, has prayed to God for twenty years to have children. ", "Esav is the first-born by just a \"split second\" and Yankle, no matter how close he feels to his brother, is always envious of his brother. ", "Yankle tricks his brother into selling his birthright for a pot a stew; Becky tricks her blind and bedridden husband, Isaac, into giving his blessings to Yankle with a \"goatskin coat\"; deception is discovered and Esav tries to kill Yankle. ", "The storyline is as close to the Bible text as can be but this is not what makes THIS book shine.", "\n\nThis story is like a kaleidoscope - with every turn of the page the focus changes and we shift our concentration on a different aspect of the tale. ", "A few of the pictures stand out and make us question the original story - not that it did not have enough ambiguity on its own, mind you - the last talk of disguised Yankle and his dying father, for example. ", "When you read it, you get a feeling that Isaac, while old and blind, might not have been fooled by the goatskin as much as we are led to believe.", "\n\nThe tale is told from Yankle's point of view, as he tells it to his own \"favorite\" son. ", "The author, by a masterful use of shifting tenses and a couple of unobtrusive references, creates an illusion that the story has happened both long time ago and in the present at the same time; which gives this story a new definition of \"Timeless.\" ", "Good read.", "\n\nUvi Poznansky is a bestseller, award-winning author, poet and artist. ", "Her boxed set, A TOUCH OF PASSION, has just become the 2016 WINNER of The Romance Reviews Readers' Choice Awards.", "\n“I paint with my pen,” she says, “and write with my paintbrush.” ", "She received a Fellowship grant and a Teaching Assistantship from the Architecture department at Rensselaer Polytechnic Institute, where she earned her M.A. in Architecture. ", "Then, taking a sharp turn in her education, she earned her M.S. degree in Computer Science from the University of Michigan.", "\n\nUvi writes across a variety of genres: Apart From Love and The White Piano (literary fiction), My Own Voice (women's fiction), The Music of Us and Dancing with Air (romance), Rise to Power, A Peek at Bathsheba, and The Edge of Revolt (historical fiction), A Favorite Son (biblical fiction), Home (poetry), Twisted (horror), and Now I Am Paper and Jess and Wiggle (children’s books.)" ]

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[ "// Copyright 2013 The Go Authors. ", "All rights reserved.", "\n// Use of this source code is governed by a BSD-style\n// license that can be found in the LICENSE file.", "\n\n// +build !", "aix,!darwin,!dragonfly,!freebsd,!linux,!netbsd,!openbsd,!solaris,!windows\n\npackage ipv6\n\nimport (\n\t\"net\"\n\n\t\"golang.org/x/net/internal/socket\"\n)\n\nfunc (so *sockOpt) setIPMreq(c *socket.", "Conn, ifi *net.", "Interface, grp net.", "IP) error {\n\treturn errNotImplemented\n}\n" ]

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[ "{{/*\n * Copyright (C) 2017 Google Inc.\n *\n * Licensed under the Apache License, Version 2.0 (the \"License\");\n * you may not use this file except in compliance with the License.", "\n * You may obtain a copy of the License at\n *\n * http://www.apache.org/licenses/LICENSE-2.0\n *\n * Unless required by applicable law or agreed to in writing, software\n * distributed under the License is distributed on an \"AS IS\" BASIS,\n * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.", "\n * See the License for the specific language governing permissions and\n * limitations under the License.", "\n */}}\n\n{{/* ---- Includes ---- */}}\n{{Include \"api_classnames.tmpl\"}}\n{{Include \"cpp_common.tmpl\" }}\n\n{{/* ---- Overrides ---- */}}\n{{Global \"C++.StringTypeOverride\" \"gapil::String\"}}\n{{Global \"C++.ArenaOverride\" \"arena()\"}}\n{{Global \"C++.Statement.", "Override\" \"Statement\"}}\n\n{{Global \"ApiIndex\" $.Index}}\n{{Global \"SpyName\" (print (Title (Global \"API\")) \"Spy\")}}\n{{$ | Macro \"SpyCpp\"}}\n\n{{define \"CommandKey\"}}\n{{.Name}}\n{{end}}\n\n{{define \"SpyCpp\"}}\n {{AssertType $ \"API\"}}\n {{range $i, $part := (Partition (AllCommands $) \"CommandKey\" 4)}}\n {{$filename := print (Global \"API\") \"_spy_\" $i \".cpp\"}}\n {{$part | Macro \"SpyCppPart\" | Reflow 4 | Write $filename}}\n {{end}}\n {{range $i, $part := (Partition $.Subroutines \"CommandKey\" 2)}}\n {{$filename := print (Global \"API\") \"_spy_subroutines_\" $i \".cpp\"}}\n {{$part | Macro \"Subroutines\" | Reflow 4 | Write $filename}}\n {{end}}\n\n{{end}}\n\n\n{{/*\n-------------------------------------------------------------------------------\n Emits all the commands passed in $ into a new C++ file.", "\n-------------------------------------------------------------------------------\n*/}}\n{{define \"SpyCppPart\"}}\n {{Template \"C++.Copyright\"}}\n {{Template \"FileHeaders\"}}\n {{$spyname := Global \"SpyName\"}}\n¶\n namespace gapii {«\n¶\n {{ForEach $ \"MethodImplementation\" | JoinWith \"\\n¶\"}}\n »} // namespace gapii\n{{end}}\n\n\n{{/*\n-------------------------------------------------------------------------------\n Emits all the subroutines for the API.", "\n-------------------------------------------------------------------------------\n*/}}\n{{define \"Subroutines\"}}\n {{Template \"C++.Copyright\"}}\n {{Template \"FileHeaders\"}}\n¶\n namespace gapii {«\n¶\n {{ForEach $ \"Subroutine\" | JoinWith \"\\n¶\"}}\n »} // namespace gapii\n{{end}}\n\n{{/*\n-------------------------------------------------------------------------------\n Emits the headers for a C++ file.", "\n-------------------------------------------------------------------------------\n*/}}\n{{define \"FileHeaders\"}}\n¶\n #include \"gapii/cc/abort_exception.h\"\n #include \"{{Global \"API\"}}_imports.h\"\n #include \"{{Global \"API\"}}_types.h\"\n¶\n #include \"{{Global \"API\"}}_spy.h\"\n¶\n #include \"core/cc/log.h\"\n¶\n #include \"gapis/api/gfxtrace.pb.h\"\n¶\n #define __STDC_FORMAT_MACROS\n #include <inttypes.h>\n¶\n #include <stdint.h>\n¶\n #include <memory>\n #include <string>\n¶\n // Silence warnings\n #pragma GCC diagnostic ignored \"-Wpragmas\" // Not all warnings are understood by all compilers!", "\n #pragma GCC diagnostic ignored \"-Wswitch-bool\" // switch condition has boolean value\n #pragma GCC diagnostic ignored \"-Wunused-variable\"\n #pragma GCC diagnostic ignored \"-Wunused-lambda-capture\"\n #pragma GCC diagnostic ignored \"-Wpessimizing-move\"\n{{end}}\n\n\n{{/*\n-------------------------------------------------------------------------------\n Emits an import declaration for an indirected command.", "\n-------------------------------------------------------------------------------\n*/}}\n{{define \"ConcatenateImports\"}}\n {{AssertType $.FromClass \"string\"}}\n {{AssertType $.ToClass \"string\"}}\n {{AssertType $.Element \"string\"}}\n mState.{{Template \"RemoveUpperPrefix\" $.FromClass}}s[{{$.Element}}]->m{{Template \"RemoveUpperPrefix\" $.ToClass}}\n{{end}}\n\n\n{{/*\n-------------------------------------------------------------------------------\n Emits a validity check for an indirected function pointer.", "\n-------------------------------------------------------------------------------\n*/}}\n{{define \"GetIndirectedFunction\"}}\n {{AssertType $.Element \"string\" }}\n {{AssertType $.Function \"string\" }}\n {{$annotation := print (index $.Annotations 0)}}\n {{if eq (len $.Annotations) 1}}\n {{$function_class := Title $annotation}}\n mImports.m{{$function_class}}Functions.find({{$.Element}}) == mImports.m{{$function_class}}Functions.end() ||\n mImports.m{{$function_class}}Functions[{{$.Element}}].{{$.Function}} == nullptr\n {{else}}\n {{$next_annotation := print (index $.Annotations 1)}}\n {{$from_class := $annotation}}\n {{$to_class := $next_annotation}}\n mState.{{Template \"RemoveUpperPrefix\" (print $from_class)}}s.find({{$.Element}}) == mState.{{Template \"RemoveUpperPrefix\" (print $from_class)}}s.end() ||\n {{$next_elements := Macro \"ConcatenateImports\" \"FromClass\" $from_class \"ToClass\" $to_class \"Element\" $.Element}}\n {{Template \"GetIndirectedFunction\" \"Annotations\" (Tail 1 $.Annotations) \"Element\" (print $next_elements) \"Function\" $.Function}}\n {{end}}\n{{end}}\n\n\n{{/*\n-------------------------------------------------------------------------------\n Emits a reference to a function pointer to an indirected function.", "\n-------------------------------------------------------------------------------\n*/}}\n{{define \"GetIndirectedCall\"}}\n {{AssertType $.Element \"string\" }}\n {{AssertType $.Function \"string\" }}\n {{$annotation := index $.Annotations 0}}\n {{if eq (len $.Annotations) 1}}\n {{$function_class := Title $annotation}}\n mImports.m{{$function_class}}Functions[{{$.Element}}].{{$.Function}}\n {{else}}\n {{$next_annotation := index $.Annotations 1}}\n {{$from_class := Title $annotation}}\n {{$to_class := Title $next_annotation}}\n {{$next_elements := Macro \"ConcatenateImports\" \"FromClass\" (print $from_class) \"ToClass\" (print $to_class) \"Element\" $.Element}}\n {{Template \"GetIndirectedCall\" \"Annotations\" (Tail 1 $.Annotations) \"Element\" (print $next_elements) \"Function\" $.Function}}\n {{end}}\n{{end}}\n\n\n{{/*\n-------------------------------------------------------------------------------\n Emits the method body for the given command.", "\n-------------------------------------------------------------------------------\n*/}}\n{{define \"MethodImplementation\"}}\n {{AssertType $ \"Function\"}}\n {{if not (GetAnnotation $ \"pfn\")}}\n {{$name := Macro \"C++.MethodName\" $}}\n {{$spyname := Global \"SpyName\"}}\n {{$synthetic := GetAnnotation $ \"synthetic\"}}\n {{$retTy := $.Return.", "Type}}\n\n {{Template \"C++.ReturnType\" $}} {{$spyname}}::{{$name}}({{Macro \"C++.CallParameters\" $ | Strings \"CallObserver* observer\" | JoinWith \", \"}}) {\n GAPID_DEBUG({{Template \"C++.PrintfCommandCall\" $}});\n¶\n {{if (and (not (GetAnnotation $ \"synthetic\")) (not (GetAnnotation $ \"override\")))}}\n if (§\n {{if (GetAnnotation $ \"indirect\")}}\n {{Template \"GetIndirectedFunction\" \"Annotations\" (GetAnnotation $ \"indirect\").Arguments \"Element\" ((index $.CallParameters 0).Name) \"Function\" (Macro \"CmdName\" $)}}\n {{else}}\n mImports.{{$name}} == nullptr\n {{end}}\n §) {\n GAPID_ERROR(\"Application called unsupported function {{$name}}\");\n return {{if not (IsVoid $retTy)}}{{Template \"C++.NullArgument\" $retTy}}{{end}};\n }¶\n {{end}}\n\n observer->enter(cmd::{{.Name}}{§\n observer->getCurrentThread(),\n {{range $i, $p := $.CallParameters}}\n {{$ty := TypeOf $p | Underlying}}\n {{if $i}}, {{end}}§\n {{if IsStaticArray $ty}}{{Template \"C++.Type\" $p}}::create({{$p.", "Name}})\n {{else}}{{$p.", "Name}}§\n {{end}}\n {{end}}\n });\n¶\n {{if not (IsVoid $retTy)}}\n {{Template \"C++.ReturnType\" $}} result = {{Template \"C++.NullArgument\" $retTy}};\n {{end}}\n\n bool called = false;\n auto call = [{{Macro \"CallCapture\" $}}] {\n called = true;\n {{if GetAnnotation $ \"frame_start\"}}\n onPreStartOfFrame(observer, {{Global \"ApiIndex\"}});\n {{end}}\n {{if GetAnnotation $ \"frame_end\"}}\n onPreEndOfFrame(observer, {{Global \"ApiIndex\"}});\n {{end}}\n\n observer->observePending();\n if (should_record_timestamps()) {\n observer->observeTimestamp();\n }\n\n {{if (GetAnnotation $ \"threadsafe\")}}\n unlock();\n {{end}}\n {{/* Perform the call */}}\n {{if not (GetAnnotation $ \"synthetic\")}}\n {{if not (IsVoid $.Return.", "Type)}}result = §{{end}}\n {{if (GetAnnotation $ \"override\")}}\n SpyOverride_{{Template \"CmdName\" $}}({{Template \"C++.CallArguments\" $}});\n {{else if (GetAnnotation $ \"indirect\")}}\n {{Template \"GetIndirectedCall\" \"Annotations\" (GetAnnotation $ \"indirect\").Arguments \"Element\" ((index $.CallParameters 0).Name) \"Function\" (Macro \"CmdName\" $)}}({{Template 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{{Template \"C++.Statement.", "Default\" $}}\n {{end}}\n{{end}}\n\n\n{{/*\n-------------------------------------------------------------------------------\n An override for the \"C++.Assign\" macro.", "\n-------------------------------------------------------------------------------\n*/}}\n{{define \"Assign\"}}\n {{AssertType $ \"Assign\"}}\n {{if (and (GetAnnotation ($.RHS | TargetField) \"spy_disabled\") ((GetAnnotation ($.LHS | TargetField) \"spy_disabled\")))}}\n // @spy_disabled\n {{else if GetAnnotation ($.RHS | TargetField) \"spy_disabled\"}}\n {{Error \"Attempting to assign from a @spy_disabled slice\"}}\n {{else if GetAnnotation ($.LHS | TargetField) \"spy_disabled\"}}\n // @spy_disabled\n {{else}}\n {{Template \"C++.Statement.", "Default\" $}}\n {{end}}\n{{end}}\n\n\n{{/*\n-------------------------------------------------------------------------------\n An override for the \"C++.SliceAssign\" macro.", 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[ "Treatment for pyothorax-associated lymphoma.", "\nIn eight patients with pyothorax-associated lymphoma (PAL), which resulted from artificial pneumothorax for the treatment of pulmonary tuberculosis, seven patients received radiotherapy and five showed no local recurrence. ", "All four patients treated by primary chemotherapy had disease progression. ", "Radiotherapy of 50 Gy with wide margins is recommended to treat PAL." ]

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[ "ARTICLE 8. ", "Source Water Protection Program [116762.60- 116762.60.]", "\n\n(a) The board shall, contingent upon receiving federal capitalization grant funds, develop and implement a program to protect sources of drinking water. ", "In carrying out this program, the board shall coordinate with local, state, and federal agencies that have public health and environmental management programs to ensure an effective implementation of the program while avoiding duplication of effort and reducing program costs. ", "The program shall include all of the following:\n\n(1) A source water assessment program to delineate and assess the drinking water supplies of public drinking water systems pursuant to Section 1453 of the federal act.", "\n\n(2) A wellhead protection program to protect drinking water wells from contamination pursuant to Section 1428 of the federal act.", "\n\n(3) Pursuant to Section 1452(k) of the federal act, the board shall set aside federal capitalization grant funds sufficient to carry out paragraphs (1) and (2).", "\n\n(b) The board shall set aside federal capitalization grant funds to provide assistance to water systems pursuant to Section 1452(k) of the federal act for the following source water protection activities, to the extent that those activities are proposed:\n\n(1) To acquire land or a conservation easement if the purpose of the acquisition is to protect the source water of the system from contamination and to ensure compliance with primary drinking water regulations.", "\n\n(2) To implement local, voluntary source water protection measures to protect source water in areas delineated pursuant to Section 1453 of the federal act, in order to facilitate compliance with primary drinking water regulations applicable to the water system under Section 1412 of the federal act or otherwise significantly further the health protection objectives of the federal and state acts.", "\n\n(3) To carry out a voluntary, incentive-based source water quality protection partnership pursuant to Section 1454 of the federal act.", "\n\n(c) The board shall post a report to its Internet Web site, every two years, on its activities under this section. ", "The report shall contain a description of each program for which funds have been set aside under this section, the effectiveness of each program in carrying out the intent of the federal and state acts, and an accounting of the\namount of set-aside funds used.", "\n\n(d) This section shall become operative on January 1 of the next calendar year occurring after the board provides notice to the Legislature and the Secretary of State and posts notice on its Internet Web site that the board has adopted a policy handbook pursuant to Section 116760.43." ]

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[ "Hotel Deauville (Miami)\n\nThe Deauville Beach Resort at 6701 Collins Ave, Miami, FL 33141, is a celebrated beachfront hotel on Miami Beach. ", "It was designed by Melvin Grossman and built in 1957.", "\n\n1920s hotel\nThe original 1926 hotel and casino was built by Joe Elsener. ", "In 1936 it became the MacFadden-Deauville after purchase by Bernarr MacFadden.", "\n\nReferences\n\nCategory:Hotels in Miami" ]

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[ "Algerian millionaire and political activist Rachid Nekkaz has promised to pay the €150 fines of any Muslim woman caught wearing the full-face Islamic veil in Austria after the ban on the garment comes into effect on October 1st.", "\n\nMr. Nekkaz (pictured, above) promised to pay all the fines for wearing the banned garment this week and received deep criticism for his offer from Austrian Foreign Minister Sebastian Kurz who initially proposed the ban last year, Austrian newspaper Kurier reports.", "\n\n“We certainly do not like this, and whoever wears a niqab or burqa in Austria has to face consequences,” Mr. Kurz said in an interview on Thursday.", "\n\nKurz said there is also a possibility that the Algerian could be committing a criminal offence by paying for other people’s fines. “", "We will not tolerate any symbolic acts that aim to build a counter-society to ours,” he warned.", "\n\nThis is not the first time Nekkaz has offered to pay for fines resulting from the wearing of banned Islamic clothing. ", "In France, Belgium, the Netherlands, and Switzerland, he and his organisation “Touche pas à ma constitution” (“Don’t touch my constitution”) have spent over 300,000 euros paying off fines and legal costs.", "\n\nAustrian broadcaster Servus TV, which is owned by Austrian energy drink giant Red Bull, claimed that Nekkaz was looking to expand his organisation into the country. “", "If one accepts religious freedom, one must also accept the visibility of religions,” Nekkaz said justifying his actions.", "\n\nAustrian Socialists Block Burqa Ban Bid https://t.co/DknpoWSP1s pic.twitter.com/Kg9SfcBko6 — Breitbart London (@BreitbartLondon) November 17, 2016\n\nThe Austrian burqa ban was initially proposed by Austrian People’s Party (ÖVP) leader Sebastian Kurz last year but was delayed for months by the Social Democrats (SPÖ). ", "The bill was finally passed earlier this year and is not specifically against the burqa and niqab but covers all facial coverings in public that makes facial features unrecognisable in public places.", "\n\nKurz has taken a harder line on migrant integration over the past year and going into next month’s elections he is a clear front-runner in the polls.", "\n\nOnly the anti-mass migration Freedom Party (FPÖ) have been more hardline with leader Heinz-Christian Strache vowing to ban Islamism and reduce migration to zero. ", "The FPÖ currently polls in second place fueling speculation of a coalition between them and Kurz’s ÖVP after the national elections on October 15th." ]

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[ "Q:\n\nWhat are/is the alternative(s) to changing the ad unit id constant all the time?", "\n\nI have an iOS app that contains ads from AdMob. ", "Since Google's Get Started guide told me not to use my own id on a simulator, I have to change between my real id and the test id all the time.", "\nWhen I am testing whether the ads will show up correctly, I use the test ids. ", "After that, I need to archive the app for updating the app in iTunes Connect. ", "This time, I need to change it to my real ids. ", "Then, I found there are some really severe bugs so I need to change it back to the test ids to do debugging. ", "After I killed the bugs, I need to change it back to real ids for another update...\nAs you can see, that is so annoying! ", "I want to find a way to just \"flip a switch\" to change the ad ids. ", "You know, when I want to change it to test ids or real ids, I can just delete a few human-readable characters (not those ad ids in some alien language) or something like that.", "\nI know I can use constants for each of the ids:\nlet testId = \"xxx\"\nlet realId = \"yyy\"\nlet adId = testId\n// And I'll use adId for all the places where required.", "\n\nWhen I want to change it to my real id, I can just\nlet adId = realId\n\nHowever, I need to change a lot of stuff if I got multiple ad ids in my app. :(", "\n\nA:\n\nI actually found the answer by myself.", "\nI found a property in GADRequest called testDevices. ", "From the description of the property:\n\nTest Ads will be returned for devices with device IDs specified in this array\n\nSo if I put a test device's ID in that array, I don't need to change the IDs every time. ", "And I found a constant called kGADSimulatorID. ", "The description of it says\n\nAdd this constant to the testDevices property's array to receive test ads on the simulator.", "\n\nSo I did this:\nlet request = GADRequest()\nrequest.testDevices = [kGADSimulatorID]\nmyAd.loadRequest(request)\n\n" ]

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[ "6,500 dead bodies dug up to make way for HS2 rail station Thousands of graves were dug up at the site, which will house a new high-speed rail station\n\n6,500 dead bodies have been dug up from a burial ground to make way for the HS2 railway station in Birmingham.", "\n\nExcavations have concluded at the site, ahead of the start of construction on a new Birmingham Curzon Street railway station for the high-speed rail project.", "\n\nThousands of bodies are buried at Birminham’s Park Street burial ground, which opened in 1810.", "\n\nThe i newsletter latest news and analysis Email address is invalid Email address is invalid Thank you for subscribing! ", "Sorry, there was a problem with your subscription.", "\n\nIt closed for public burials in 1873, after operating for 63 years.", "\n\nOver a 12-month period, a team of archaeologists dug up more than 6,500 graves, discovering a wealth of artefacts including figurines, coins, toys and necklaces.", "\n\nHS2 bosses say the remains will be reburied at a suitable location in consultation with the Church of England.", "\n\nCareful and fascinating excavation\n\nClaire Cogar, Lead Archaeologist from MOLA Headland, said: “The careful and fascinating excavation of Park Street burial ground is telling us a great deal of the effects of life in 19th-century Birmingham on the population.", "\n\n“We hope to build a picture of the lives of the people who built Birmingham and made the city what it is today, from the diseases they suffered and what they ate, to where they came from.", "\n\n“Our initial findings have already identified evidence of diseases including scurvy and rickets.", "\n\n“We have also found interesting objects placed into burials. ", "One burial contained a bone-handled knife, another had a figurine and others contained dinner plates.", "\n\n“These finds provide insights into the types of burial rituals, traditions and practices of the 19th-century.”", "\n\nMike Lyons, HS2 West Midlands Programme Director, said: “Birmingham is at the heart of the HS2 network and we’re proud to have reached this first major milestone in the construction of Curzon Street station.", "\n\n“We already know that Birmingham played a pivotal role in the Industrial Revolution and HS2’s archaeology programme will allow us to tell the story of the skilled workers who fuelled it.", "\n\n“As part of our commitment to being a good neighbour, we’ve teamed up with the National Trust’s Heritage Open Days where we will be sharing with the local community our discoveries and insights from the site and what we’ve learned so far.”", "\n\nHS2 review\n\nThe future of the HS2 project is currently up in the air, with Transport Secretary Grant Shapps ordering an independent review into “whether and how” the project to link Northern cities to London by high-speed rail should proceed.", "\n\n\n\nRead More HS2: Campaigners warn 11 ancient woodlands still under threat despite temporary reprieve\n\nAfter reports that costs had spiralled to as much as £88bn , Mr Shapps said: “The Prime Minister has been clear that transport infrastructure has the potential to drive economic growth, redistribute opportunity and support towns and cities across the UK, but that investments must be subject to continuous assessment of their costs and benefits.", "\n\n“That’s why we are undertaking this independent and rigorous review of HS2.”", "\n\nThe London to Birmingham section of HS2 was due to open at the end of 2026, but could now be delayed to 2031." ]

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[ "Q:\n\nHow did the Time Lords put a whole \"Star\" in a Tardis?", "\n\nHow did the Time Lords put a whole \"Star\" in a Tardis?", "\nDo they have some kind of galaxy shrinking technology or what do they use?", "\n\nA:\n\nTime and Relative Dimensions In Space - TARDIS\nWe've seen plenty of episodes where the TARDIS is enormous. ", "In fact, the episode The Name of the Doctor gives us a hint that it's not just bigger on the inside, it's HUGE (size leak)\n\nThe catch here is that's not just a star, it's a collapsing star. ", "From Journey to the Centre of the TARDIS\n\nDOCTOR: The Eye of Harmony. ", "Exploding star in the act of becoming a black hole. ", "Time Lord engineering. ", "You rip the star from its orbit, suspend it in a permanent state of decay.", "\n\nThis type of star is called a Eye of Harmony. ", "The Doctor's version is a mere copy, with the original residing on Gallifrey. ", "Apparently Rassilon was capable of such a feat\n\nAccording to the ancient records, the legendary Time Lord Rassilon captured and placed the Eye – the nucleus of a black hole – beneath the Time Lord's citadel on Gallifrey (the Panopticon). ", "Rassilon placed the black hole's nucleus in an eternally dynamic equation against the mass of Gallifrey and so that as long as the Eye existed in this \"balanced state\", the power of the Time Lords would \"neither flux nor wither\". ", "However, it remained there so long that it passed into legend.", "\n\nAs was Omega\n\nOmega was a solar engineer who, in trying to provide an energy source for the Time Lords' time travel experiments, harnessed the power of a supernova. ", "\n\nFrom The Satan Pit\n\nDOCTOR: I'm just towing you home. ", "Gravity schmavity. ", "My people practically invented black holes. ", "Well, in fact, they did.", "\n\nThe implication is that these ancient Time Lords knew how to manipulate gravity and space in fantastic ways. ", "As such, moving a star into something the size of a phone booth would have been trivial.", "\n\n" ]

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[ "Maruca Pérez\n\nMaruca Pérez (died 18 March 1937) was a Mexican singer, known for being the first female performer of Agustín Lara's songs and one of the first Mexican tango singers. ", "In 1929, she recorded at least four songs—including Lara's \"Canalla\" and \"Mentira\"—for the Victor label. ", "She was also an exclusive artist of radio station XEB in the 1930s.", "\n\nDiscography\n \"Canalla\" (recorded 11 June 1929)\n \"Mentira\" (recorded 11 June 1929)\n \"Flor de fango\" (recorded 17 June 1929)\n \"Arrepentida\" (recorded 17 June 1929)\n\nReferences\n\nCategory:1937 deaths\nCategory:20th-century Mexican singers\nCategory:20th-century women singers\nCategory:Mexican female singers\nCategory:Tango singers\nCategory:Victor Records artists\nCategory:Year of birth missing" ]

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[ "Joshua Lowcockhttps://www.joshualowcock.com\nNew YorkMon, 18 Feb 2019 03:20:09 +0000enhourly1https://wordpress.org/?v=5.0.32019.02.15 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/QDZZRlGfBj0/\nSun, 17 Feb 2019 22:45:18 +0000http://www.joshualowcock.com/?p=1789Here’s your Last Week in Digital Media. ", "GENERAL Apple is rumored to be close to launching a Netflix-style magazine subscription service (off the back of the Texture acquisition last year). ", "Reports put it at being announced this March. ", "The WSJ reports (paywall) that Apple will be seeking to take a 50/50 split on the subscriptions which publishers are resisting. ", "There is no word… Read more →\n\nA new anonymous messaging app “Telonym“, an amalgam of “tell on him” and anonymous is reportedly causing concern for parents. ", "Given the popularity of the app with teens, expect rapid copying of the less-controversial features by the major platforms.", "\n\nAmazon acquired mesh WiFi router maker Eero for an undisclosed sum. ", "The acquisition is a further step towards Amazon’s move to own everything that makes a smart-home smart. ", "Subject to any new Terms of Services (ToS), the acquisition would also help provide Amazon insights into internet use in a home across everything outside of the Amazon universe.", "\n\nDuring the week, notable tech journalist Kara Swisher did a live tweet interview with twitter CEO Jack Dorsey. ", "The interview was very hard to follow in real time and didn’t reveal anything meaningful (Dorsey was very evasive) but it did demonstrate twitter isn’t really a good place to do a live interview. ", "If you want to read the full transcript, recode has it on their website.", "\n\nreddit is positioning itself as a challenger in the social media advertising space, with reddit raising US$300MM to invest in their website and taking ad share from Google and Facebook. ", "An interesting highlight of the capital raising is that reddit’s Average Revenue Per User (ARPU) at US$0.30, the lowest of any social media platform based on a reported 330MM users.", "\n\nLinked In has started rolling out a beta of a live streaming video product called Linked In Live (US-only). ", "The service is invite-only for now and is intended to stay in the same tone as the overall platform e.g. event streaming, product launches, entrepreneur Q&As. ", "To help ensure the videos look professional, Linked In has struck deals with live streaming tool providers like Wirecast and Switcher.", "\n\nThis is an unusual one and it’s hard to know where it sits legally, but there’s a new online streaming service called locast that streams local TV stations for free. ", "Currently available in 9 US cities, the service claims to have legitimacy as a not-for-profit public digital translator (aka relay) service.", "\n\nAI\n\nInteresting news in the world of AI. ", "A little talked of fact is eCommerce websites typically price match using bots and AI (that’s why so many sites have you add to cart before you can see the price to try and game the bot-system). ", "Research out of Italy shows that unconnected price matching AI can learn to collude and increase prices. ", "That is, ask what checks and balances exist in the system to ensure that the best interests of consumers and clients are protected.", "\n\nREGULATORY\n\nthe UK Parliamentary inquiry into Disinformation and “Fake News” has published their final report. ", "Among key findings, it calls for a mandatory Code of Ethics for tech. ", "companies and states that it believes “Facebook intentionally and knowingly violated both data privacy and anti-competition laws“. ", "The report highlights some harsh truths for everyone in the industry, including that UK electoral laws are not fit for purpose when it comes to social media. ", "A fact that holds true everywhere in the world.", "\n\nthere are multiple reports that Facebook is about to enter into a multi-billion dollar settlement with the FTC around Cambridge-Analytica and other data privacy incidents from 2018. ", "This will be something to watch. ", "It would give a preview of how the FTC views privacy, if there is a new consent-decree it would change how Facebook goes to market in advertising, and it will set the direction for how the industry uses data.", "Editorial Observation: The previously cited UK Parliamentary report notes on pp26, paragraph 76 “If (Facebook) had fully complied with the FTC settlement, (Cambridge Analytica) would not have happened“. ", "If the UK Parliamentary report reached this conclusion, it’s difficult to imagine the FTC arriving at a different position.", "\n\nthe UK has published the results of a study into the future of journalism and news industry titled “the Cairncross Review“. ", "The full report is 157pp (pdf link) and is relevant to the ad industry as it calls out the reduction of supply in public-interest journalism as a “market failure” and questions whether the rise and power of Google and Facebook will require government intervention. ", "While a UK-based report, the themes, and findings do resonate across countries given the challenges are common to news organizations everywhere.", "\n\nBefore I wrap this week, a brief housekeeping update. ", "Due to weekend client travel, I may not be able to publish an update next week. ", "I will try my best to find time to write an update and send a newsletter but ask for your patience if I miss a week.", "\n\n]]>https://www.joshualowcock.com/digital-media-news/2019-02-15-last-week-in-digital-media/2019.02.08 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/8kgEMuOGs4I/\nSun, 10 Feb 2019 22:45:50 +0000http://www.joshualowcock.com/?p=1769Here’s your weekly dose of Last Week in Digital Media, here’s what you might have missed. ", "GENERAL The Spotify rumor from last week was confirmed. ", "with Spotify acquiring Gimlet Media and also Anchor. ", "This gives Spotify a significant leg up and lead in owned and non-owned original content. ", "In a blog post by Spotify founder, Daniel Ek, he outlines an expectation… Read more →\n\nFacebook turned 15 years old during the week and Zuckerberg posted an update reflecting on how the company has grown and the challenges it faces. ", "Zuckerberg did gloss over the real fundamental issues, as the update has an optimistic tone. ", "If you’re interested in a retrospective look at how the homepage has changed, check out this link and check out what job title Zuckerberg gave himself.", "\n\nThe IPG Media Lab published its Innovation Outlook for 2019 “Unintended Consequences”. ", "It’s a great read and despite the Lab’s observation that “Public perception (of digital) has notably shifted from techno-utopianism to wary optimism, if not outright skepticism.” ", "there is plenty of innovation, inspiration, and optimism in the report. ", "It’s worth your time to review.", "\n\nWhile the Superbowl drew most of your attention last Sunday, there was something else happening. ", "Over 10MM players connected into Fortnite concurrently to see a live concert from Marshmello. ", "Given the success and size of the audience, expect this to be one of many live in-game entertainment events this year (and not just from Fortnite)\n\nMEDIA & TECH Q4 RESULTS\n\nSnapchat’s Q4 results showed a positive turn around for the company. ", "Ad revenue was up 36% (US$390MM), Global Daily Active User (DAU) numbers were flat at 186MM (79MM in the US). ", "Snapchat also claims to reach 70% of those aged 13-34 with ads each month. ", "Of the stats buried further down which is interesting to note is that the Snapchat Pixel (for conversion tracking) saw 600MM conversion events in Q4, up from 230MM. ", "Meaning Snap seems to be making rapid inroads as a transaction platform.", "\n\ntwitter has a good Q4, with twitter’s results with Q4 revenue of US$909MM (up 24%). ", "twitter did change how they report numbers, introducing the metric Monetizable Daily Active Users (mDAUs) and stating the number was up 9% to 126MM. ", "twitter said they will stop reporting Monthly Active Users (MAUs) but did say that MAUs were down 9MM from last year (sitting at 321MM). ", "You can deep dive into the numbers in twitter’s investor report here (PDF link).", "\n\nThe WSJ reports that a DoubleVerify investigation found a scheme by bad actors to thwart ads.txt. ", "The scheme involved taking advantage of the lax process and controls in 3rd party re-sellers. ", "It serves as a reminder that applying standards and verification tools do not substitute for vigilance.", "\n\nFacebook is making updates to its Custom Audience Transparency Tool. ", "Detailed in a Facebook post, from Feb 27th, if a user clicks to find out “Why am I seeing this?” ", "button next to an ad, it will reveal not only why a person was targeted, but if the advertiser used their customer list to target you.", "\n\nTechCrunch has a story about several popular mainstream apps that have screen recording analytics software from a company called Glassbox. ", "The problem (and there are many) is the recording of user behavior is not disclosed to users, does not ask for user consent, may capture and disclose sensitive user information, and the data may be monetized. ", "Apple is not happy about this and has notified the developers of the apps in question that they are in “violation of (Apple’s) strict privacy terms and guidelines, and (Apple) will take immediate action if necessary“. ", "This is worth flagging with any client that has an app, as Glassbox isn’t the only company offering app screen-recording analytics services.", "\n\n]]>https://www.joshualowcock.com/last-week-in-digital-media/2019-02-08-last-week-in-digital-media/2019.02.01 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/pc0_qVUfDH8/\nSun, 03 Feb 2019 22:00:31 +0000http://www.joshualowcock.com/?p=1757An earlier edition of Last Week in Digital Media in an attempt to get your attention before the Super Bowl (or Superb Owl, as Google might have you believe). ", "Here’s the news you may have missed: GENERAL Hulu is working on a new pause-based advertising unit available in Q2 of this year. ", "The ad unit appears more like a banner,… Read more →\n\nHulu is working on a new pause-based advertising unit available in Q2 of this year. ", "The ad unit appears more like a banner, on the right side of the screen with Hulu taking steps to address concerns around viewability, user-experience, and brand safety. ", "Charmin and Coca-Cola are early adopters of the ad unit.", "\n\nAn advertising pitch deck from TikTok has been leaked. ", "Digiday has published a copy of the TikTok pitch (paywall). ", "The deck only has numbers for European users. ", "Showing that Germany and France are the top markets with ~4MM active monthly users respectively. ", "Overall, the user ratio is 54:46 (female:male). ", "Ad products are: Brand takeover; in-feed native video; hashtag challenge; and Snapchat-style 2D lens filters for photos\n\nPRIVACY / APPLE-GOOGLE-FACEBOOKAT WAR\n\nThere was a brief all-out war between Apple, Google, and Facebook during the week. ", "While it didn’t impact advertisers or consumers, it has far reaching implications across everyone the industry when it comes to data, market research, and developing apps for Apple’s ecosystem. ", "The following attempts to track and summarize the timeline of events, but to be clear there was no client or advertiser impact.", "\n\nFacebook was making the app available via an Apple Enterprise Certificate a developer program for companies to make available apps to their staff only. ", "Apple stated Facebook’s research app violated Apple’s terms.", "\n\nIt then emerged that Google also had a similar research-based app. ", "Like Facebook, Apple said the way it was being deployed was in breach of Apple’s terms.", "This is where it all gets interesting and evolved into a hot war on Privacy.", "\n\nAfter talks between all parties, on Thursday Apple restored the Enterprise Certificates for Facebook and Google.", "Editorial:What are the implications of all of this? ", "On one hand, it shows that Apple’s position as a protector of consumer privacy is something they were prepared to act on (although many have pointed out Apple makes US$12B by making Google the default on Safari). ", "There’s another counter point which is Apple over-stepped the mark, because these were opt-in consent-based market research programs not publicly available apps so all participants knew what they were doing vs other privacy scandals. ", "It might also be an own-goal by Apple as a current class action lawsuit that alleges the AppStore is a monopoly is not as easy to defend when you start shutting down apps from competitors that the CEO has openly criticized (and where there is an active feud) . ", "For advertisers and marketers, the lesson is that Apple has set a precedent where it will make decisions to take action where it sees a privacy issue against Apple’s own rules, adding not just the need to be regulatory compliant but ensuring you don’t cross-the-line with Apple.", "\n\nMEDIA & ADTECH Q4 RESULTS\n\nFacebook’s Q4 results were surprisingly good despite a year filled with controversy. ", "The decline in Monthly and Daily Active Users in the US has stopped and revenues were up. ", "The full Facebook investor presentation (PDF link) has useful slides with all of the key metrics (2.7B people now use Facebook, WhatsApp, or Instagram). ", "In the earnings call (PDF transcript) Facebook did warn of “headwinds that (Facebook) might face on targeting given the overall privacy landscape in 2019“.", "\n\nVerizon’s Q4 results, on the Verizon Media Group side, saw revenue down 5.8% (pdf link) and that the content/media focus would be “super channels” namely Yahoo! ", "Sports, News, Finance, and Entertainment.", "\n\nStreamLabs (a company that offers apps and services to streamers) published a report called “State of the Stream” focused on game streaming. ", "The free report shows that twitch continues to dominate eSports streaming (just over 3x YouTube Gaming) and Fortnite while still the most popular has declined slightly.", "\n\nOver the holiday period, there was a great article in the Economist about the importance of identity and a case of someone’s identity being deleted and stolen in 1409 (and the wide ranging impacts). ", "You can read the article here (paywall).", "\n\nIntegral Ad Science (IAS) released a study that showed data privacy is the top priority for the industry (56% of respondents). ", "The survey sampled 900 advertising professionals. ", "You can download the report for free (registration required).", "\n\n]]>https://www.joshualowcock.com/last-week-in-digital-media/2019-02-01-last-week-in-digital-media/2019.01.25 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/DZv9RjRC4-4/\nSun, 27 Jan 2019 22:45:30 +0000http://www.joshualowcock.com/?p=1751Welcome to another update, here’s what you might have missed Last Week in Digital Media. ", "GENERAL Mark Zuckerberg posted an Op-Ed on the WSJ titled “The Facts About Facebook“. ", "The post has been criticized by some for being dismissive of the challenges and concerns faced over the past 12 months. ", "However, there is a positive takeaway (paraphrasing) where Zuckerberg affirms… Read more →\n\nMark Zuckerberg posted an Op-Ed on the WSJ titled “The Facts About Facebook“. ", "The post has been criticized by some for being dismissive of the challenges and concerns faced over the past 12 months. ", "However, there is a positive takeaway (paraphrasing) where Zuckerberg affirms “important principles around data are transparency, choice, and control … (and) … regulation that codifies these principles across the internet would be good for everyone“. ", "It’s the first time Zuckerberg has publicly come out in support of regulation vs industry self-regulation.", "\n\nThere are reports the Facebook plans to integrate WhatsApp, Facebook Messenger, and Instagram Messenger. ", "The apps would stay as standalone services, but they would share common infrastructure and you could message across platforms. ", "There is a lot of speculation about what is driving this, from technological efficiency, monetization, a defensive against rivals, to a pre-emptive move against regulators who may want to break up Facebook’s services.", "\n\nONLINE VIDEO / OTT\n\nAnother week, another acquisition in the OTT space. ", "This time, Viacom acquired Pluto TV for US $340MM. ", "Pluto is ad-supported, has around 12MM active monthly users with more than half watching via Smart TVs. ", "Pluto TV is free and an interesting OTT provider as it bundles content into channels, providing a more cable-like experience.", "\n\nBRAND SAFETY\n\nFacebook has introduced brand safety certification for Facebook Marketing Partners (FMPs). ", "Partnering with DoubleVerify (DV) and OpenSlate (IAS is still in development). ", "The solution enables advertisers/agencies to review Facebook’s publisher list and create a unique block based on your a clients brand safety profile. ", "For more information on the offering, reach out Facebook or your contact at DV or OpenSlate.", "\n\nThere is a thought-provoking interview and article on the Guardian with Shoshana Zuboff, the author of new book called “The Age of Surveillance Capitalism“. ", "The thesis being that data collection and being able to predict future behaviors is the future (and current) driver of capitalism, that society is separating into the “watchers” and the “watched” and the implications for society and democracy are significant. ", "A must read and the phrase “surveillance capitalism” feels like it will be part of the industry lexicon this year.", "\n\nAnother state is making moves to introduce privacy legislation, this time it is Washington State. ", "If successful, between California and Washington, the US could end up with a defacto national privacy standard given the major tech companies are founded in and have HQs in either state.", "\n\nThere’s always a lot of speculation about the break-up of big tech (Google, Facebook, Amazon). ", "Bloomberg has an interesting interview with Congressman Cicilline, the Chairman of the Antitrust Committee and his perspective that anti-trust covers both competition and protecting rights online, as well as the possibility of auditing algorithms. ", "Worth taking the time to read.", "\n\nHave a wonderful week.", "\n\nJoshua\n\nPS. ", "A tip this week is this phishing education quiz from Google. ", "While those of in corporate environments benefit from training in how to spot suspicious emails, sometimes family members don’t get the same exposure. ", "The quiz is helpful to share if you’re concerned family or friends might be a victim of a scam.", "\n\n]]>https://www.joshualowcock.com/last-week-in-digital-media/2019-01-25-last-week-in-digital-media/2019.01.18 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/onRNoGcHUKU/\nSun, 20 Jan 2019 22:45:11 +0000http://www.joshualowcock.com/?p=1736Here’s the news you may have missed last week in digital media. ", "GENERAL Spotify continues to work on ways to make their music service the go-to in every part of your daily life. ", "This time with a car-view mode in the Android version of the Spotify app, so that the app is easier to use and less distracting when driving… Read more →\n\nFacebook is working on yet-another app targeted at teens, this time called “LOL“. ", "The app is in a private-beta with high school students (all under NDA). ", "Details are light, but the app is allegedly a meme hub with a Snapchat Discover-like experience.", "\n\nPopular group video chat app, Houseparty, has integrated the popular mobile game Heads Up. ", "as part of a move towards monetization. ", "Heads Up opens the possibility for branded game packs that could be packaged and sold as sponsored extras to marketers, opening up integrated ad opportunities on the platform.", "\n\nThe IAB Tech LabDataLabel.orgtransparency initiative (like nutrition labels for data targeting) is now in beta and open for comment. ", "The DataLabel demo doesn’t include all available data, just selected sets from participating partners and allows you to compare up to 3 data sets.", "\n\nOTT / VIDEO\n\nNetflix’s quarterly results are out, with the company adding 1.53MM US domestic subscribers. ", "This puts their total number of US domestic subscribers at just over 60MM or another way to look at it – an additional 1.53MM people decided to opt for an ad-free content experience and require better media and content strategies to reach them.", "\n\nA telling line in Netflix’s letter to shareholders (PDF link, pp 5, Competition) was that they “compete with (and lose to) Fortnite more than HBO”. ", "Demonstrating why clients should look to eSports and gaming as part of their media strategy as gaming is winning part of the war for attention.", "\n\nAre people comfortable with their data being used for targeted advertising? ", "A new Pew Research study suggests when it comes to Facebook, the answer is no. ", "Just over half of those surveyed were uncomfortable with Facebook compiling information on them and almost 3/4 were unaware the data was even collected (or the ad preferences page existed). ", "As for the accuracy of the data collected, just over 1/4 said the data Facebook had collected was not accurate. ", "The full report (PDF) can be downloaded here and it’s a good reminder that the industry needs to better explain everything from data collection to how targeting works (and why it is needed to fund content).", "\n\nApp Analytics company AppAnnie has released a report (PDF, free registration required) on the state of mobile in 2019. ", "The detailed report (160pp) has some interesting stats, including that WhatsApp is Facebook’s most popular app/service (pp 49) and several pages of useful stats of the most popular apps are by usage, spend, and download across multiple countries (pp68 onwards). ", "It’s worth taking some time to go through the report.", "\n\nPRIVACY, TRUST, AND BRAND SAFETY\n\nMicrosoft is working a privacy initiative called Project Bali. ", "that would give users complete control of how their data is used. ", "The project page is going on/offline constantly, but it’s all based off a Microsoft whitepaper called “Inverse Privacy“. ", "It makes for a fascinating perspective on how privacy is a challenge because of records-control by the individual (not an invasion of privacy) and that future competitive advantage will come to companies who give users control over their data. ", "It also talks about small data, which is a whole different topic but very interesting concept.", "\n\nPS. ", "A favor to ask this week. ", "I have been writing this update for 3 years now and I’m just shy of 500 subscribers. ", "If you have a moment, it would be great if you find this newsletter useful it would be great if you could forward this email onto someone at UM or IPG with a note to encourage them to subscribe.", "\n\n]]>https://www.joshualowcock.com/last-week-in-digital-media/2019-01-18-last-week-in-digital-media/2019.01.11 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/F_cgHiSEau8/\nSun, 13 Jan 2019 22:45:12 +0000http://www.joshualowcock.com/?p=1712Welcome back to Last Week in Digital Media and the first one for 2019. ", "Lot’s of news this week! ", "CES 2019 The best download from CES innovation comes from the IPG Media Lab and I recommend you read their blog posts highlighting each day. ", "During my walks of the floor, what stood out was “assistant everywhere”. ", "Whether it was Google Assistant… Read more →\n\nCES 2019\nThe best download from CES innovation comes from the IPG Media Lab and I recommend you read their blog posts highlighting each day. ", "During my walks of the floor, what stood out was “assistant everywhere”. ", "Whether it was Google Assistant or Amazon Alexa, the ability to connect, support, or have them integrated into devices was prevalent across so many devices. ", "There were smart toilets, smart closets, smart Set Top Boxes, and smart plug-ins for your car. ", "There’s clearly a belief across hardware and device makers that consumers value integrated assistant features. ", "The lesson from CES is that brands and marketers in 2019 would be well placed to think about how smart assistants and voice can form part of both product and marketing strategies in the year ahead (and what device makers they may consider as partners).", "\n\nGENERAL\n\nAmazon rarely discloses any specific numbers for Amazon Prime or other services, but in an interview with the Verge, Amazon’s SVP of services said that more than 100MM devices with Alexa on board have been sold. ", "Amazon is also sold out of Echo dots until February 2019.", "\n\nGoogle Chrome’s built-in capability to adblockunacceptable (aka highly disruptive) ads will go global as of July 9, 2019. ", "A reminder, if you want to know what sort of ads are at risk of being blocked, visit the BetterAds.org standards page.", "\n\ntwitter is developing new analytics tools for publishers and events. ", "The latter is the most interesting, as it also feeds into a product that will make it easier for users to tune in to events and what’s trending at said events without having to follow specific users or accounts (and unlock more event-based ad opportunities on the platform).", "\n\nA reminder, Oath: is now rebranded as Verizon Media. ", "This is not really a surprise, given Verizon took a write-down on the Oath: assets in the final weeks of 2018.", "\n\nThe are reports Amazon is working on a game streaming service. ", "This is not to be confused with eSports / watching people play games (remember Amazon owns twitch in that category), it’s the delivery/ability to play games on any almost any device by streaming them from a central server. ", "This is an important an emerging content area, with nVidia (GeForce Now), Google (Project Stream) and Microsoft (Project X Cloud) all experimenting with game streaming.", "\n\nAmazon is working on a revised influencer strategy according to leaked documents. ", "The influencer program would share a commission back with influencers who promote products, with higher commission rates for Amazon’s owned and operated brands. ", "Influencers would also be incentivized to promote other Amazon offerings like Fresh, Music, etc.", "\n\nA company called Tablo has a beta of DVR that will automatically skip adsin recorded content by leveraging AI and the cloud infrastructure. ", "To automatically skip ads in DVR’d content. ", "To access the capability, users will need to pay a monthly US$5 subscription.", "\n\nAmazon’s free ad-supported streaming service is now official, it’s called IMDB Freedive and operates via the IMDB brand. ", "The service includes movies, TV and IMDB originals (not to be confused with Amazon originals).", "\n\nIn the year-end review, Zuckerberg acknowledged many of Facebook’s 2018 (many) challenges although ended optimistically on how Facebook has contributed to communities. ", "The long-promised Clear History tool was mentioned but no launch timeline proposed. ", "The most interesting statement was Facebook is “working to establish an independent body that people can appeal decisions to and that will help decide our policies“. ", "Hopefully, this will help Facebook make better decisions in 2019.", "\n\nIn Zuckerberg’s personal challenge is “is to host a series of public discussions about the future of technology in society“. ", "This is somewhat a continuation of his 2018 listening tour.", "\n\nDNA testing company, 23andme, has taken a US$300MM investment from GlaxoSmithKline (GSK). ", "Sparking debate about data privacy in the DNA testing category and articles on how to delete your 23andme data. ", "It’s reasonable to expect that the GSK investment will fuel more calls for Federal data regulation in the US.", "\n\nA Trustworthy Accountability Group (TAG) study in Europe revealed that using TAG certified inventory ad fraud rates dropped from 9% to 0.53%. ", "The full TAG European Benchmark study is here (PDF) and underscores why you should ensure you always ask partners if their inventory is TAG certified.", "\n\n]]>https://www.joshualowcock.com/last-week-in-digital-media/2019-01-11-last-week-in-digital-media/2018.12.14 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/FZWK8uguUmI/\nSun, 16 Dec 2018 22:45:34 +0000http://www.joshualowcock.com/?p=1704It’s the last Last Week in Digital Media for the year. ", "Thanks for reading, sharing, and notes of encouragement throughout the year. ", "GENERAL The IPG Media Lab has published an excellent retrospective of the year, reviewing progress in six (6) key areas from regulation, to voice search and AR. ", "Something to read and reflect on over the holiday break and prior… Read more →\n\n]]>It’s the last Last Week in Digital Media for the year. ", "Thanks for reading, sharing, and notes of encouragement throughout the year.", "\n\nGENERAL\n\nThe IPG Media Lab has published an excellent retrospective of the year, reviewing progress in six (6) key areas from regulation, to voice search and AR. ", "Something to read and reflect on over the holiday break and prior to CES.", "\n\nFacebook is testing search ads again (the last time was back in 2013). ", "It’s being tested in the US and Canada and only applies when making retail-related searches in the automotive and eCommerce categories. ", "The best news, is the Facebook Search Ads are currently free – they just need to be set up in Ad Manager if you’re account/client is eligible.", "\n\nNielsen published their Q2 Total Audience Measurement report. ", "Some highlights include that free (broadcast) TV was up (now 13% of all US homes), virtual Multichannel Video Programming Distributors (vMVPDs) which includes Hulu, YouTube TV are up, and radio is holding strong at 93%. ", "Total media consumption, across all devices, sits at 10 hours per day but that includes multiple devices, sharing the same hours.", "\n\n]]>https://www.joshualowcock.com/last-week-in-digital-media/2018-12-14-last-week-in-digital-media/2018.12.07 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/oN-6Axr5hNs/\nSun, 09 Dec 2018 22:45:56 +0000http://www.joshualowcock.com/?p=1696Welcome back to Last Week in Digital Media. ", "This week, I’ll include some of the major stories that broke during my the newsletter hiatus. ", "This will also be the second last update of the year given the Holiday season is just around the corner. ", "FACEBOOKThe last issue covered revelations about Facebook’s alleged behavior toward competitors. ", "During the week, the UK… Read more →\n\n]]>Welcome back to Last Week in Digital Media. ", "This week, I’ll include some of the major stories that broke during my the newsletter hiatus. ", "This will also be the second last update of the year given the Holiday season is just around the corner.", "\n\nthe documents seized from Six4Three reveal details on Facebook’s decisions about data, privacy, and who should have access to that data (API partners, advertisers, etc). ", "There is no positive news for Facebook in the information that has been released.", "\n\nThe first page of the PDF document has 6 takeaways, NY Times has published their 4 key takeaways, and Insider has published a list of seven. ", "All of them show Zuckerberg being personally involved in decisions to cut-off competitor access; the company is focused on what’s good for Facebook even if it’s not good for the world; and Facebook being open to circumventing privacy and data controls if it served Facebook’s interests.", "\n\nEditorial: Facebook comes across as somewhat tone deaf and blind to concerns about the matters that have come to light in the documents. ", "There is also very little being said proactively by Facebook about privacy or data protection. ", "Facebook’s Chief Privacy Officer has been notably silent as of writing this. ", "With data and privacy regulation firmly on the horizon for 2019, Facebook is doing neither themselves or the industry favors right now. ", "This headline (and article) on Forbes sums it up best “Facebook still doesn’t understand what privacy means“.", "\n\nGENERAL\n\nthe Stories format, pioneered by Snapchat, is now coming to Linked In. ", "The format will be tested first in an offering aimed at students called “Student Voices”. ", "If you want to see what it looks like within the app and you’re a) reading this on your phone and b) have the Linked In app installed – click this link. ", "Otherwise, check out the Linked In stories sizzle reel here.", "\n\nit’s reported that Instagram is testing a more cards-based UI, bringing an end to the scrolling feed. ", "If the test proves successful and becomes the default UI, it would enable richer, better viewable, full-screen mobile ads on the platform.", "\n\nHulu is on track to have 23MM subscribers by the end of 2018. ", "The details were revealed by Hulu’s CEO (Randy Freer) at the Business Insider Ignition conference. ", "Freer did hint that international expansion is coming, ad revenue remains a key part of the model, but did not reveal details or speculate on Disney might do given it is/will be a major shareholder.", "\n\nA reminder, Google will turn off annotations in YouTube on January 15th. ", "This has been expected for over a year now, with the ability to annotate new videos being discontinued back in May of 2017 but worth reminding clients in case they have legacy videos using the feature.", "\n\nthe IAB has released a draft ads.txt spec for mobile apps called app-ads.txt. ", "It’s important that the industry encourages partners to adopt this standard, which would provide more transparency and safety in the mobile ecosystem, particularly helping to eliminate fraudulent inventory.", "\n\nfrom the UK and as reported by The Drum, “the UK government’s intelligence and security committee has called on parliament to apply pressure on brands in an effort to “force” the removal of terrorist and extremist material by withdrawing ad spend from platforms like YouTube and Facebook.” ", "This is something to take note of, as it makes brand safety broader than just ad adjacency and more about the entire platform.", "\n\n]]>https://www.joshualowcock.com/digital-media-news/2018-12-07-last-week-in-digital-media/2018.11.16 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/S6sgAoqonSo/\nSun, 18 Nov 2018 22:45:09 +0000http://www.joshualowcock.com/?p=1677Yes, I know I said there wouldn’t be the Last Week in Digital Media update this week but given the Facebook news (read on) I had to find a way to get an update out. ", "I hope you find it useful. ", "FACEBOOK The New York Times published an article on Facebook that alleges an executive-led process of denial, cover-up, and really questionable… Read more →\n\nEditorial: There are more questions than answers after all of the reports and leaks. ", "There is definitely a need for transparency and Facebook needs to demonstrate it can (and deserves to) be trusted by users, government, and advertisers. ", "Perhaps the most positive thing to come out the news cycle is Zuckerberg’s proposal of an independent Content Governance & Enforcement group. ", "Although, this is a solution that is needed across all major tech. ", "platforms not just Facebook and it feels like 2019 is set to be the year of industry regulation.", "\n\nGENERAL\n\nSomewhat random, but just in time for the holiday season Snapchat is making available for sale personalized Bitmoji merchandise. ", "Products cover everything from clothes to cushions and shower curtains. ", "The move is possibly rooted in a need for Snapchat to get better insights into how eCommerce will work on the platform. ", "The Bitmoji store will be US-only.", "\n\nin news out of Malaysia, Netflix is launching a mobile-only pricing tier, to be more price competitive in the region. ", "It’s interesting because it shows advertising isn’t necessary to subsidize cheaper subscription pricing and also recognizes that mobile-only subscription offerings may have a place.", "\n\nIn other Snapchat news, Snap’s VP of Content (Nick Bell) has resigned. ", "Bell will remain until the end of the year and oversaw Snap Originals. ", "Bell was also the original product owner of the Snapchat Discover offering. ", "Snap CEO has re-affirmed Snap’s commitment to originals and content despite Bell’s departure.", "\n\nTRUST, SAFETY & PRIVACY\n\nLost amongst all the Facebook drama, was an important GDPR ruling out of France. ", "I encourage you to read the full tweet thread by NY Times reporter Robin Berjon. ", "In short, an unknown French location data company “Vectaury” was found to be collecting data without consent (no fine, able to remediate) but it does call into question in-app consent and also the validity of IAB Consent framework. ", "Notably “You cannot pass consent to another controller through a contractual relationship”. ", "To quote Berjon “This means that if someone gains consent for you, and you have a contract saying it’s their responsibility to do so, you *still* have the obligation to verify that the consent is valid.” ", "There’s a lot more to come on this ruling and make sure you get the appropriate legal advice.", "\n\n]]>https://www.joshualowcock.com/digital-media-news/2018-11-16-last-week-in-digital-media/2018.11.09 Last Week in Digital Mediahttp://feedproxy.google.com/~r/JoshuaLowcock/~3/vAn4KcaKVRE/\nSun, 11 Nov 2018 22:45:58 +0000http://www.joshualowcock.com/?p=1669There will be no Last Week in Digital Media for the next few weeks, updates will resume in December. ", "If you miss the newsletter, there is always the archive, every past issue is available online. ", "GENERAL Amazon has launched an Alexa app for Windows 10 PCs. ", "Available for free from the Windows Store, the app works with Alexa skills and continues… Read more →\n\nVerizon announced that they are organizing Oath: underneath “Verizon Media Group“. ", "There’s some confusion on this news, whether it means the Oath: name is dead (or dying). ", "According to conversations with people at Verizon and Oath: it’s less the name is being retired and for the short term it’s about an internal business unit re-organization. ", "From a practical standpoint, nothing changes day to day.", "\n\nIf you’re ever struggling for a way to understand or explain viewability, there’s a great demo on ThinkWithGoogle that shows (in real time) just how viewability works. ", "Worth a look and you should share with your clients and teams.", "\n\nFacebook’srumored TikTok competitor (Lasso) is now live. ", "The app is available on iOS and Android and is branded as “Short, Fun, Videos”. ", "To use Lasso you must have either a Facebook or Instagram account.", "\n\nPandora’s Q3 results saw the music service add 784,000 subscribers, with total active premium users sitting at 6.8MM. ", "This is smaller than numbers reported by Spotify (87MM) and Apple Music (50MM), A reminder, the Pandora/Sirius XM deal is still pending and is expected to close in Q1 2019.", "\n\nPRIVACY, TRUST & SAFETY\n\nThe ongoing browser-based approach to clean up cookies, advertising and pop-ups continue. ", "A lot of news in this area during the week, with Opera Mobile blocking cookie dialog boxes (that have spiked post-GDPR). ", "Separately, Chrome 71 will block all ads on a site that has abusive user experiences. ", "Publishers will be warned and have a 30day notice period before all ads are blocked (there isn’t yet a way for agencies to see if a site is being flagged for abusive experiences)." ]

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[ "@echo off\nREM Licensed to the Apache Software Foundation (ASF) under one\nREM or more contributor license agreements. ", " See the NOTICE file\nREM distributed with this work for additional information\nREM regarding copyright ownership. ", " The ASF licenses this file\nREM to you under the Apache License, Version 2.0 (the\nREM \"License\"); you may not use this file except in compliance\nREM with the License. ", " You may obtain a copy of the License at\nREM \nREM http://www.apache.org/licenses/LICENSE-2.0\nREM \nREM Unless required by applicable law or agreed to in writing,\nREM software distributed under the License is distributed on an\nREM \"AS IS\" BASIS, WITHOUT WARRANTIES OR CONDITIONS OF ANY\nREM KIND, either express or implied. ", " See the License for the\nREM specific language governing permissions and limitations\nREM under the License.", "\n\nSET runpath=%~dp0\n\nPowerShell.exe -NonInteractive -ExecutionPolicy bypass -File %runpath%cleanup.ps1 %*\n" ]

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[ "[Treatment of inguinal lymph node recurrence after chemo-radiation for anal canal squamous carcinoma].", "\nAlthough it is well established that the standard primary treatment for anal canal squamous cell carcinoma is chemoradiation, the strategy varies for recurrence cases. ", "A 76-year-old woman was diagnosed by biopsy as Stage II (T2N0M0) squamous cell cancer and treated with a total amount of 60 Gy pelvic radiation excluding the groin area, and oral chemotherapy of S-1 (60 mg/m2/day) for 4 weeks. ", "Two years after initial therapy, she had a recurrence at the right inguinal lymph nodes. ", "We resected her right inguinal lymph nodes and added 20 Gy photon radiations to both sides of the inguinal area. ", "She has been recurrence-free for 4 years after the surgery. ", "For recurrent anal canal squamous cell carcinoma, salvage surgery for the original lesion and systemic chemotherapy for distant metastasis are the standard strategy. ", "For inguinal lymph node metastasis such as in this case, unilateral lymph node resection and adjuvant radiation for the bilateral groin area are recommended by the guidelines of National Comprehensive Cancer Network (NCCN)." ]

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[ "The Ilitch family confirmed that Mike and Marian Ilitch's son Ronald Ilitch has died.", "\n\nChristopher Ilitch released the following statement on behalf of his mother and the family:\n\nOn behalf of my mother Marian Ilitch and our entire family, I want to express our sadness and grief at Ron’s passing. ", "We’re devastated about this loss, and we ask for respect of the family’s privacy during this difficult time.", "\n\nTroy police are investigating the death. ", "Officers immediately responded to a 911 call from a woman who reported that a man was on the ground, not breathing.", "\n\nFirst responders found Ronald laying face up on the floor of the hotel room. ", "There were no immediate signs of trauma to the body.", "\n\nTroy police are investigating to determine the cause of his death. ", "An autopsy confirmed there was no apparent trauma to his body.", "\n\nPolice say personal use amount of narcotics were found in the hotel room, the majority of which were prescription narcotics.", "\n\nRonald has a history of drug abuse. ", "He was on probation from a 2014 drug case at the time of his death.", "\n\nIlitch is one of Mike and Marian Ilitch's 7 children, a member of the family that owns the Detroit Red Wings, Detroit Tigers and Little Caesars Pizza, which is currently run by his brother Christopher." ]

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[ "Share this:\n\nIndoor air quality is the first criteria many architects and government agencies look at when specifying products for LEED buildings and other projects geared to minimizing the environmental footprint. ", "Features such as zero VOCs, low odor, resistance to mildew and an anti-microbial, silica-free formula combine to make Health Kote and Vantage Plus by Diamond Vogel Paints plus Harmony, Emerald and Pro Marr 200 XP from Sherwin Williams the ultimate paint choice for these projects.", "\n\nSpecifying zero-VOC or low-VOC paints is a great start, but Don Carvey Painting can help residential and commercial customers take their green efforts to an even higher level by understanding and extolling the values of durability.", "\n“Green is defined not only as low-VOC, explains Don Carvey owner of Don Carvey Painting. “", "Durability is just as important.”", "\n\nDon Carvey Painting uses higher quality coatings products, so we paint our clients’ properties less often. ", "Over the years, reducing the number of repaints helps reduce waste and emissions. ", "Similarly, the use of paints like Health Kote and Vantage Plus by Diamond Vogel Paints plus Emerald, Haromony and ProMar 200 XP from Sherwin Willliams helps reduce emissions and waste by allowing the use of one less coat than standard competitive coatings.", "\n\nDon Carvey Painting also shows its customers their green commitment by choosing a paint supplier that not only produces high-quality, low-VOC coatings, but extends that green idea into all of its operations. ", "Sherwin-Williams and Diamond Vogel Paints are a good example of that kind of forward-thinking organization. ", "Industry leaders in the green coatings movement, both companys invests millions of dollars a year in the research and development of advanced, innovative coatings.", "\n\nThe world left behind for future generations is of the utmost concern to Diamond Vogel. ", "Diamond Vogel is built on the strength of generations dedicated to providing the best paints and coatings available to protect homes, offices and equipment from natural deterioration. ", "They have developed practical, sustainable coating solutions that minimize their environmental impact while maintaining the high level of quality you’ve come to expect from Diamond Vogel.", "\n\nSherwin-Williams scientists have created formulas using sustainable raw materials like soy and sunflower oil, and continually try to improve productivity and reduce emissions by developing coatings that require fewer coats and repaints. ", "Improvements to their manufacturing process and distribution system further conserve natural resources.", "\n\nIn the end, painters who emphasize the importance of durability and indoor air quality, while choosing a paint supplier with a company-wide green focus, show customers their commitment to a better environment.", "\n\nLearn more about Sherwin-Williams and Diamond Vogel “Green” products and initiatives." ]

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[ "Printed Circuit Board (PCB) layouts are designed with help of PCB drawing software’s, commonly known as pcb layout design software. ", "Here we are listing you a collection of free pcb design softwares which are simple, easy to use and available for ready download. ", "PCB design tools fall into many categories based on their development platform, pricing strategies etc. ", "We aim to give you a mixed collection free download softwares, open source pcb design softwares, enterprise level softwares (which requires license). ", "All the softwares listed here contains links to download pages of software websites and you are free to download these tools based on their terms and conditions. ", "So let’s begin the list.", "\n\nOpen Source PCB Design Software\n\nFree PCB– is an open source pcb design software released under GNU license, made specifically for Micrososft Windows. ", "Free pcb is a simple, easy to use design tool, whose features include 1 to 16 copper layers, board size upto 60 inches by 60 inches, Footprint libraries and wizard etc. ", "Though Free pcb seems like an easy, hobbyist type tool, it can be used for your basic professional works too.", "\n\nBSch3V – is a basic pcb schematic drawing software, which can carry out your basic needs only. ", "The software is developed for Windows operating system. ", "Though its so basic, we list this pcb software here because of its simple nature so that a lay person can use it very easily and efficiently.", "\n\nExpressPCB – is a pcb design tool for the professional which is easy to learn and simple to use. ", "This free cad software comes with two divisions – ExpressSCH for drawing schematics and ExpressPCB for drawing circuit board layouts. ", "This software is compatible for Windows Xp, Vista and 7. ", "Drawing circuit diagram in ExpressPCB is as easy as placing components and connecting them.", "\n\nKicad – is an open source schematic diagram drawing software and printed circuit board design tool. ", "This software is released under GPL license and is a combination 4 applications and a project management tool. ", "Eeschema – is used for schematic entry, Pcbnew – as board editor, Gerbview – as photo plotter, Cvpcb – as footprint selector for pcb, and Kicad – as project manager. ", "This application works with both Linux and Windows (2000 and XP).", "\n\nPCB 123 – is a free circuit drawing and pcb layout software from Sunstone. ", "We at CircuitsToday use this software for the last 3 years to draw circuits. ", "And that’s why you see unique style diagrams in all our electronic circuits. ", "Though there are many other good software’s available, we still stick on to PCB123 to maintain this unique style. ", "Well, this software is worth your time for a try.", "\n\nPCB Layout Tool – is a free, simple printed circuit board layout tool. ", "You can use this extremely simple software to make layouts of even complex circuits. ", "It is capable of producing RS-274X and Excellon NC-drill format output.", "\n\nEagle (Light Edition) – Eagle is one of the most popular Circuit drawing and PCB layout software available in the market. ", "Most professionals,students and hobbyists find Eagle as an ideal choice for their PCB development needs. ", "Eagle in fact is an enterprise PCB designing software but they are offering a lighter version (with limitations compared to enterprise application) for free download. ", "And to your good news, Eagle will run on Windows, Linux and Mac.", "\n\nCan you please tell me which circuit designing software has SMD component database, as I have used PCB Wizard, Express PCB, Free PCB, PCB 123, but it do not have SMD component database. ", "It’s very good for through hole." ]

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[ "The U.S. Congress does not suffer from endless gridlock as some of the banal liberal pundits and commentators moan about.", "\n\nJust yesterday, by a vote of 98-2, the U.S. Senate voted for confrontation, imperialism and sanctions against Russia, Iran and North Korea. ", "The nearly unanimous Senate vote followed a nearly unanimous vote in the House (419-3) for a similar measure.", "\n\nThe Republicans in Congress initiated the legislation, with the eager support of their lapdog friends from the Democratic Party. ", "These measures are designed to provoke confrontation. ", "Speaker Paul D. Ryan called the passage of the House version as “one of the most expansive sanctions packages in history.”", "\n\nBernie Sanders and Rand Paul were the only two senators to vote No. ", "Sanders earlier cited opposition to new sanctions on Iran. ", "The bill clearly violates the terms of the agreement with Iran whereby the country allowed its nuclear energy program to be strictly limited and monitored in exchange for the lifting of economic sanctions. ", "Sanders said he supported new sanctions against Russia. ", "By all measure, imperialist-sponsored economic sanctions and blockades are a form of war.", "\n\nEven as Republicans were frantically trying to ram through laws that will strip health care from millions of people, the Democrats in Congress eagerly embraced their colleagues and joined them as a united chorus for imperialism.", "\n\nThe Democratic Party politicians’ unity with the Republicans in support of bullying of Russia, Iran, North Korea, and Venezuela is far greater than their still tepid criticism of Trump and the Republicans’ domestic policy, which constitutes a war against the working class and all poor people at home.", "\n\nThe People’s Congress of Resistance which convenes in Washington D.C. on September 16-17, 2017 will represent those in the United States who resist imperialism rather than function as its mouthpiece.", "\n\nVisit www.congressofresistance.org to get involved" ]

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[ "My Santa sent my a super cool solar powered car. ", "And an otter is space. ", "I love otters. ", "Like love love love otters. ", "Thank you so much Santa!! (", "A little shout out- apparently my Santa has a store and makes these things)" ]

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[ "Vittoria (name)\n\nVittoria is an Italian female given name taken from the male name Victor.", "\n\nPeople with the given name Vittoria include:\nVittoria Aganoor, poet\nVittoria Aleotti, composer and organist\nVittoria Archilei, singer, dancer and lutenist\nVittoria Belvedere, actress\nVittoria Bentivoglio, singer \nVittoria Colonna, noblewoman and poet\nVittoria Cremers, theosophist\nVittoria della Rovere, noblewoman\nVittoria Farnese d'Este, noblewoman\nVittoria Puccini, actress\nVittoria Risi, pornographic actress\nVittoria Tesi, opera singer \n\nCategory:Italian feminine given names" ]

{ "pile_set_name": "Wikipedia (en)" }

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[ "Q:\n\nIs passing pointers to functions similar to calling a function by reference?", "\n\nI don't really see any difference, with passing pointers to functions and calling a function by reference. ", "Am I right\n#include <stdio.h>\n\nint multi;\n\nint multiplication(int *a, int *b){\n multi = (*a) * (*b);\n\n return multi;\n}\n\nint main()\n{\n int X = 2, Y=3;\n multiplication(&X, &Y);\n\n printf(\"%d\", multi);\n return 0;\n}\n\nA:\n\nFrom the example code you show, you obviously mean pass by reference, not call by reference.", "\nThere is no pass by reference in C, it's always pass by value. ", "Of course, you can get the effect of pass by reference by passing a pointer to something. ", "The pointer is your reference. ", "It's again passed by value, but you use that value to access some other object.", "\nLanguages that have pass by reference will typically use pointers to implement it.", "\n\n" ]

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[ "Q:\n\nTranslate the following English sentences into symbolic sentences with quantifiers.", "\n\nthis is my solution of my homework, is that true 100%? ", "Please if there is any mistake tell me because my professor is so careful.", "\nThanks. (", "Sorry, I don’t speak English well)\n\ni) Translate the following English sentences into symbolic sentences with quantifiers. ", "The universe for each is given in parentheses.", "\nii) Then For each of the propositions write a useful denial symbolically.", "\niii) and give a translation into ordinary English.", "\n\n.", "\n\na) Not all precious stones are beautiful. (", "All stones)\n\ni) $(\\exists x)[(x\\ is \\ precious \\ stone) \\land \\sim (x \\ is \\ beautiful)]$\nii) $(\\forall x)[(x\\ is \\ precious \\ stone)\\Rightarrow (x \\ is \\ beautiful)]$\niii) All precious stones are beautiful. (", "All stones)\n\nb) All precious stones are not beautiful. (", "All stones)\n\ni) $(\\forall x)[(x\\ is\\ precious \\ stone) \\Rightarrow \\sim ( x \\ is\\ beautiful)]$\nii) $(\\exists x) [(x\\ is\\ precious \\ stone) \\land ( x \\ is\\ beautiful)]$\niii) Not all precious stones are not beautiful. (", "All stones)\n\nc) Some isosceles triangle is a right triangle. (", "All triangles)}\n\ni) $(\\exists x)[( x\\ is\\ isosceles\\ tringle) \\land (x\\ is\\ a\\ right\\ tringle)$\nii) $(\\forall x) [( x\\ is\\ isosceles\\ tringle) \\Rightarrow \\sim (x\\ is\\ a\\ right\\ tringle)]$\niii) For all isosceles triangle is not a right triangle. (", "All triangles)\n\nd) No right triangle is isosceles. (", "All triangles)\n\ni) $(\\forall x)[(x\\ is\\ a\\ right\\ tringle)\\Rightarrow \\sim (x\\ is\\ isosceles)]$\nii) $(\\exists x)(x\\ is\\ a\\ right\\ tringle)\\land(x\\ is\\ isosceles)$.\niii) There exist a right triangle is not is isosceles. (", "All triangles)\n\ne) All people are honest or no one is honest. (", "All people)\n\ni) $(\\forall x)[(x\\ is\\ a\\ person) \\Rightarrow (x\\ is\\ honest)] \\lor (\\forall x)[(x\\ is\\ a\\ person) \\Rightarrow \\sim (x\\ is\\ honest)]$\nii) $(\\exists x)[(x\\ is\\ a\\ person)\\land \\sim (x\\ is\\ a\\ honest)]\\land (\\exists x)[(x\\ is\\ a\\ person)\\land (x\\ is\\ a\\ honest)]$\niii) There exist a person is not honest and there exist a person is honest. (", "All people)\n\nf) Some people are honest and some people are not honest. (", "All people)\n\ni) $(\\exists x)[(x\\ is\\ preson) \\land (x\\ is\\ honest)]\\land (\\exists x) [(x\\ is\\ preson) \\land \\sim (x\\ is\\ honest)]$\nii) $(\\forall x)[(x\\ is\\ preson) \\Rightarrow \\sim (x\\ is\\ honest)]\\lor (\\forall x) [(x\\ is\\ preson) \\Rightarrow (x\\ is\\ honest)]$\niii) All people are not honest or all people are honest. (", "All people)\n\ng) Every nonzero real number is positive or negative. (", "Real numbers)\n\ni) $(\\forall x)[((x\\in \\mathbb{R})\\land (x\\neq 0))\\Rightarrow (x>0)\\lor (x<0)]$\nii) $(\\exists x) [((x\\in \\mathbb{R})\\land (x\\neq 0)) \\land ((x\\leq 0)\\land (x \\geq 0)) ]$\nor, $(\\exists x) [((x\\in \\mathbb{R})\\land (x\\neq 0)) \\land ((x< 0)\\land (x > 0)) ]$\nwhat is the true?", "\niii) There exist nonzero real number is negative and positive.", "\nor, There exist nonzero real number is non-positive and non-negative.", "\nWhat is the true?", "\n\nh) Every integer is greater than −4 or less than 6. (", "Real numbers)\n\ni) $(\\forall x) [(x\\in \\mathbb{Z})\\Rightarrow(x>-4)\\lor (x<6)]$\nii) $(\\exists x)\\bigg[(x \\in \\mathbb{Z})\\land [(x\\leq -4)\\land (x\\geq 6)]\\bigg ]$\niii) There exist integer number is less than or equal to -4 and greater than or equal to 6.", "\n\ni) Every integer is greater than some integer. (", "Integers)\n\ni) $(\\forall x) [(x \\in \\mathbb{Z})\\Rightarrow [(\\exists y)(y \\in \\mathbb{Z})\\land (x>y))]]$\nii) $(\\exists x)\\bigg[(x \\in \\mathbb{Z})\\land [(\\forall y) (y \\in \\mathbb{Z})\\Rightarrow (x\\leq y)]\\bigg]$.\niii) There exist an integer number is small or equal to every integer. (", "Integers)\n\nj) No integer is greater than every other integer. (", "Integers)}\n\ni) $\\sim (\\exists x)(x\\in \\mathbb{Z})\\land (\\forall y)(y\\in \\mathbb{Z})\\Rightarrow (x>y)$\nor $(\\forall x)(x\\in \\mathbb{Z})\\Rightarrow (\\exists y)(y\\in \\mathbb{Z})\\land (x\\leq y)$\nii) $(\\exists x)\\bigg[(x \\in \\mathbb{Z})\\land [(\\forall y) (y \\in \\mathbb{Z})\\Rightarrow (x>y)]\\bigg]$\niii) here exist an integer is greater than every other integer.", "\n\nk) Between any integer and any larger integer, there is a real number. (", "Real numbers)\n\ni) $[(\\forall x)(x\\in \\mathbb{Z})\\land (\\forall y)(y\\in \\mathbb{Z}\\land x<y)]\\Rightarrow (\\exists z)(z\\in \\mathbb{R})\\land (x<z<y) $\nii) $(\\forall x)[(x\\in \\mathbb{Z})\\land (\\forall y) ((y\\in \\mathbb{Z})\\land x<y)]\\land (\\forall z)[(z \\in \\mathbb{R})\\Rightarrow (x\\geq z \\geq y)]$\niii) how can I write it?", "\n\nl) There is a smallest positive integer. (", "Real numbers)}\n\ni)$(\\exists x)[(x\\in \\mathbb{Z})\\land (x>0) \\land ((\\forall y)(y \\in \\mathbb{Z})\\land (y>0) \\Rightarrow (x \\leq y))]$\nii) $(\\forall x)(x\\in \\mathbb{Z}\\Rightarrow (x\\geq 0))\\lor ((\\exists x)(y\\in \\mathbb{R})\\land(x>y))$\niii) There is a greatest non-positive integer.", "\n\nm) No one loves everybody. (", "All people)\n\ni) $(\\forall x) [(x\\ is\\ a\\ preson)\\Rightarrow [(\\exists y)(y\\ is\\ a\\ preson)\\land (\\sim(x\\ loves\\ y))]] $\nii) $(\\exists x)\\bigg[(x\\ is\\ a\\ person)\\land [(\\forall y)(y\\ is\\ a\\ person)\\Rightarrow (x\\ loves\\ y)]\\bigg]$\niii) Some people loves every body. (", "All people)\n\nn) Everybody loves someone. (", "All people)}\n\ni)$(\\forall x)[(x \\ is \\ a \\ person)\\Rightarrow (\\exists y)(y\\ is\\ a\\ person)\\land ( x\\ loves\\ y)]$\nii) $(\\exists x)\\bigg[(x\\ is\\ a\\ person)\\land [(\\forall y)(y\\ is\\ a\\ person)\\Rightarrow \\sim (x\\ loves\\ y)]\\bigg]$\niii) Some people don't loves any body.", "\n\no) For every positive real number $x$, there is a unique real number $y$ such that $2^y=x$ (Real numbers)\n\ni) $(\\forall x)[(x\\in \\mathbb{R})\\land (x>0)\\Rightarrow [(\\exists ! ", "y)(y\\in \\mathbb{R})\\land (2^y=x)]]$\nii) $(\\exists x)\\big[((x \\in \\mathbb{R})\\land (x>0))\\land [\\sim (\\exists ! ", "y)(y\\in \\mathbb{R})\\land (2^y=x)] \\big]$\nor, $(\\exists x)\\bigg[((x \\in \\mathbb{R})\\land (x>0))\\land [[(\\exists y)(y\\in \\mathbb{R})(y\\ is\\ not\\ unique)\\land (2^y=x)]\\lor [\\sim (\\exists y)(y\\in \\mathbb{R})\\land (2^y=x)]\\lor [(\\forall y)(y\\in \\mathbb{R})\\Rightarrow (2^y=x)]]\\bigg]$\nor, $(\\exists x)\\bigg[((x \\in \\mathbb{R})\\land (x>0))\\land [[(\\exists y)(y\\in \\mathbb{R})(y\\ is\\ not\\ unique)\\land (2^y=x)]\\lor [(\\forall y)(y\\in \\mathbb{R})\\Rightarrow (2^y\\neq x)]\\lor [(\\forall y)(y\\in \\mathbb{R})\\Rightarrow (2^y=x)]]\\bigg]$\niii) There exist positive real number x, and there is a real number \"not unique\" y such that $2^y=x$, or for every a real number y then $2^y\\neq x$, or for every a real number y then $2^y= x$.\nis that true please? ", "Thanks.", "\n\nA:\n\nGood work, well done!", "\nA small issue is that, sometimes like in i), j), k), m), n) and o), you forget $\\land$.\nIn k), I'm sure you mean $x<z<y$.\nOtherwise everything else sounds good to me. ", "Well done!", "\nEdit: (After including questions ii) and iii))\nIn g)ii), both answers you gave are correct. ", "The first is a direct application of what you know about negative statements The second is still obtained from the first based on the fact that $x\\in\\mathbb{R}$ and $x\\neq 0$.\nI also am not sure about your translation in g)iii). ", "I guess you know that negative means $x<0$ while nonpositive means $x\\le 0$.\nk)ii) is wrong.", "Just do the same thing than earlier to k)ii). ", "After this, \nl)ii) is wrong. ", "The negation of $x>0$ when $x\\in\\mathbb Z$ is $x\\le 0$. Also it's $\\exists y$ that should follow, not $\\exists x$. Finally, don't throw away $y<0$.\nFor o), it will help to know the following: if $\\varphi(x)$ is a formula, $$\\exists! ", "x \\varphi(x)$$ is equivalent to $$\\exists x (\\varphi(x) \\land(\\forall y (\\phi(y)\\implies y=x)))$$.\n\nA:\n\nYes, that is mostly okay. ", " (Some person are preson...)\nIn $i, j, k, m, n, o$, you have writen $(∃y)(y∈\\Bbb Z)(x>y)$ and such when it should be $(∃y)(y∈\\Bbb Z\\land x>y)$ ... or $(\\forall y)(y∈\\Bbb Z\\to x>y)$ as appropriate.", "\nAlso, are you allowed to use the uniqueness quantifier ($\\exists!$) in $o$?", "\n\n" ]

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[ "About I'm getting rid of stuff before I move out of Victoria. ", "If you see something you want, leave a message in the ask box or email smasuch@electricmilk.com" ]

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[ "Recommendation systems are increasingly becoming more prominent in improving online content discovery and enhancing user experience. ", "The presentation of recommendations can be based, inter alia, on click through rate (CTR) estimation on a given recommendation. ", "In many cases, recommendation systems are embedded within domains of dynamic nature where changes in properties of the domain may influence the performance of the recommender. ", "For example, user interface elements within a webpage, independent of the recommender, may bias user attention and affect the probability for a click. ", "One challenge of a recommendation system is to be able to detect these dynamic properties and perform user interaction analysis in order to avoid compromises in prediction quality." ]

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[ "UFC Fight Night 30 Attendance and Gate Numbers\n\nThe Ultimate Fighting Championship returned to Manchester, England, on Saturday, for its third tour of duty in the city.", "\n\nUFC Fight Night 30: Machida vs. Munoz took place at the Phones 4u Arena drawing an audience of 10,355 and producing a live gate of $1.5 million, according to UFC officials.", "\n\nThose numbers are solid, but still well below the UFC’s past performances in Manchester. ", "UFC 70 on April 21, 2007, drew 15,114 fans for a gate of $2.6 million. ", "On Nov. 14, 2009, UFC 105 attracted 16,693 in attendance for a gate of $2 million.", "\n\nFormer UFC light heavyweight champion Lyoto Machida made his middleweight debut in the UFC Fight Night 30 main event. ", "He scored another highlight reel knockout, putting out his former training partner and current friend Mark Munoz with a kick to the head." ]

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[ "Manufacturers\n\nFlamingo Nose (Box of 12) 61390\n\n$22.80 Sale Ends Today!: ", "$21.66\n\nAdd to Cart:\n\nDescription\n\nDetails\n\nReviews\n\nThe box of 12 flamingo noses are made from latex and comes with an elastic strap which will hold the nose tight on your face. ", "These highly detailed Halloween noses look realistic and are manufactured to fit big kids to adults." ]

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[ "Q:\n\nHow to find the monoticity of the following function\n\nI am trying to find where the following function is increasing and decreasing\n$$f(x)=\\arcsin\\left(\\frac{1-x^2}{1+x^2}\\right).$$\nI found that at $x=0$ the function is not differentiable because the limit from above and below are not equal. ", "Also, the point found is a global maxima. ", "But with this information how can I find where it is increasing and decreasing? ", "Taking the first derivative and studying where it is positive gives that it should increase for all $x$, even though it is not true. ", "\nWhat am I missing?", "\n\nA:\n\nHint:   $\\sin(x)$ is strictly increasing on $[-\\pi/2,\\pi/2]$, so $f(x)$ has the same monotonicity as $\\sin(f(x))=\\dfrac{1-x^2}{1+x^2}=-1+\\dfrac{2}{1+x^2}\\,$, which should be easy to verify as even and decreasing for $x \\ge 0$, so the only extremum is a maximum at $x=0$.\n\nA:\n\nNote that\n$$f'(x)=\\frac{d}{dx} \\sin^{-1}\\left(\\frac{1 - x^2}{1 + x^2}\\right) = -\\frac{2 \\sqrt{\\frac{x^2}{(x^2 + 1)^2}}}{x}$$\nthus since\n\n$f'(x)<0 \\quad \\forall x>0\\implies \\quad f(x)$ is increasing \n$f'(x)>0 \\quad \\forall x<0\\implies \\quad f(x)$ is decreasing \n\n" ]

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[ "St Mary's Clonmel\n\nSt Mary's GAA is a senior Gaelic Athletic Association hurling and Camogie club. ", "The club is located in the town of Clonmel, County Tipperary in Ireland. ", "It is part of the South Division of Tipperary GAA.", "\n\nAchievements\n South Tipperary Senior Hurling Championship (1) 1981\n Tipperary Intermediate Hurling Championship (1) 2017\n Tipperary Junior A Hurling Championship (1) 1975\n South Tipperary Junior B Hurling Championship (2) 2004, 2006\n South Tipperary Under-21 Hurling Championship (5) 1977, 1985, 1986, 1987, 1988\n Tipperary Minor Hurling Championship (2) 2015, 2016\n South Tipperary Minor Hurling Championship (19) 1937, 1939, 1950, 1953, 1954, 1957, 1967, 1968, 1974, 1975, 1977, 1980, 1985, 1986, 1987, 1988, 2010, 2012, 2015\n South Tipperary Minor B Hurling Championship (2) 2006, 2008\n\nNotable players\n Séamus Kennedy\n Paudie O'Neill\n\nReferences\n\nExternal links \nOfficial web site\nGAA Info Profile\nTipperary GAA site\n\nCategory:Gaelic Athletic Association clubs in County Tipperary\nCategory:Hurling clubs in County Tipperary" ]

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[ "Q:\n\nIs there a way to compile Free Pascal code to a Symbian OS .sis\n\nWe all know that Free Pascal can compile for the platforms that support Symbian OS, so is it possible to, painfully I must say, get a method to compile to the .sis format?", "\nMany thanks!!", "\n\nA:\n\nThe port of Free Pascal to Symbian OS is not pretty ready yet. ", "Though it is capable of writing helloworld applications, stdlib is not fully available yet.", "\n\n" ]

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[ "\nIs a Billion $ Powerball Finally Profitable to Play? - ", "baldeagle\nhttp://databozo.posthaven.com/is-a-billion-dollars-powerball-finally-profitable-to-play\n======\nbaldeagle\nTL;DR: Nope.", "\n\n" ]

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[ "\n250 F.Supp.2d 78 (2003)\nStewart J. RODAL, Plaintiff,\nv.\nANESTHESIA GROUP OF ONONDAGA, P.C, Defendant,\nNo. ", "00-CV-1386.", "\nUnited States District Court, N.D. New York.", "\nMarch 18, 2003.", "\nStewart L. Weisman, Esq., ", "Manlius, NY, for Plaintiff.", "\nThomas C. Kingsley, Esq., ", "Syracuse, NY, for Plaintiff.", "\nScolaro, Shuman, Cohen, Lawler & Burstein, P.C. (Shari R. Cohen, Esq., ", "of Counsel), Syracuse, NY, for Defendant.", "\n\nMEMORANDUM DECISION AND ORDER\nMUNSON, Senior District Judge.", "\nPlaintiff is a board certified anesthesiologist and a shareholder in defendant Anesthesia Group of Central New York, P.C. (\"the Group\"). ", "The Group a domestic professional corporation located in Syracuse, and it primarily provides anaesthesia and related services at the St. Joseph's Hospital Health Center, Syracuse, New York, (\"the Hospital\") and the North Medical Center, Liverpool, N.Y. (\"the Medical Center\"). ", "In 1983 plaintiff became an attending physician with the Group in 1986, he became a board certified anesthesiologist *79 and was invited by the Group to become a shareholder. ", "Plaintiff accepted the offer, and entered into an Employment Contract with the Group.", "\nIn 1994, plaintiff became ill with a disease that was subsequently diagnosed as a metastatic islet cell tumor, a rare form of a cancerous tumor of the cells that manufacture insulin.", "\nIn April 1995, plaintiff contacted the Group leader, Dr. Ascioti, to discuss a lighter work schedule due to his illness. ", "As a result of this meeting, plaintiff began working at the North Medical Center outpatient facility with no night calls or weekend shifts. ", "Additionally, he would continue to oversee the Group's billing office which was located there.", "\nIn July 1995, a meeting was held by the Group to consider if a blend of partial disability insurance benefits paid for by the Group, and direct compensation from the Group, would provide plaintiff with an income level that was reasonable based on his then current contribution to the Group. ", "A proposal was formulated but was rejected by plaintiff because the combined insurance benefits and compensation paid by the Group would not approximate his full time income.", "\nThereafter, although the terms of plaintiffs Employment Agreement with the Group provided that it had no obligation to continue his compensation for more that 90 days (April-July), plaintiff received his full salary and benefits for a nine month period from April 1995, through January 1996. ", "Other Group members covered all of plaintiffs night and weekend calls throughout this period, in addition to their own, with no additional compensation for their endeavors. ", "The minutes of the Group corporate meeting of November 6, 1995, noted that plaintiff intended to again assume his call duties at the Hospital starting in January, 1996, and he did so.", "\nDue to the concern that the accommodation given to plaintiff greatly exceeded the time period set forth in the Employment Contract, the Group decided to revise its Employment Contract to cover employee disability periods exceeding 90 days. ", "A proposed revision was drafted which provided that, if the disabled employee could perform at least sixty percent (60%) of his former duties during a ninety day accommodation period, the employer would continue the employee's compensation in full for an additional period of 90 days. ", "The revision provision was presented to the Group's members for discussion at the Group's Board Meeting of December 4, 1995, and was executed by members of the Group at their Board Meeting on January 8, 1996. ", "Plaintiff was present at both meetings, and signed the revision execution document, two months after he had decided to return to call duties.", "\nIn January 1996, plaintiff returned to a full work schedule although the medications he was taking caused him discomfort. ", "This discomfort compelled him to pay other doctors to cover his shifts on an irregular basis. ", "Plaintiff continued on a full work schedule into 1999, but due to the effects of his medication, fatigue and personal problems, he requested Dr. Ascioti to consider decreasing his work schedule. ", "Plaintiff claims that Dr. Ascoti never considered his request, and his appeals to individual members of the Group were unavailing. ", "He therefore, advised Dr. Ascioti in June 1999, that he would be going on full disability in mid-July 1999. ", "Plaintiff maintains that defendant should have accommodated his reduced work hours request because he could still perform the essential functions of his profession but not on a full time basis.", "\nOn June 21, 1999, plaintiff attended a meeting of the Group's Board of Directors. *", "80 During the meeting, a Group member proposed that plaintiff be given the position of manager of the billing office because he was qualified for the work since he had created the business office. ", "Although the attendees apparently expressed approval of this proposal, it does not appear that a formal vote was taken on it. ", "Plaintiff later learned that the proposal was tabled.", "\nSometime between June 21 and July 17, 1999, the position of business manager or consultant was created by the Group, and William Killroy was hired to fill it. ", "Plaintiff alleges that this position was the same as the billing office manager's he had previously requested and was qualified for, but the Group did not advise him of the decision to create this position, or given a chance to apply for it. ", "The Group does not agree that the new position was the same as that of the billing office manager.", "\nOn May 5, 2000, plaintiff filed a Charge of Discrimination by the Group with the Buffalo Office of the Equal Employment Opportunity Commission (\"EEOC\") alleging violations of Title VI of the Civil Rights Act of 1964, 42 U.S.C. § 2000e, the Age Discrimination in Employment Act of 1967, 29 U.S.C. §§ 621-634, and the Americans with Disabilities Act of 1990 43 U.S.C. § 1210(ADA). ", "The EEOC complaint alleged only one ADA violation, the denial of an available administrative position. ", "In its Dismissal and Determination letter dated June 28, 2000, the EEOC stated that \"the evidence fails to indicate that a violation of the law occurred and it is not likely that an additional investigation will result in our finding of a violation.\" ", "The correspondence further stated that it had no jurisdiction over the claim because plaintiff was a shareholder and Vice President of the Board of Directors of the Group. ", "The letter also contained a notice of right to institute a lawsuit on the charge within 90 days.", "\nThis action was commenced September 13, 2000. ", "The complaint alleges violations of the American with Disabilities Act, 42 U.S.C. § 12101, et seq. (\"", "the ADA\"), jurisdiction is founded on 28 U.S.C. §§ 1331 and 1343(a)(4), supplemental jurisdiction is also invoked under 28 U.S.C. § 1367. ", "Plaintiff asserts that defendant Group violated the ADA by declining to reasonably accommodate plaintiff by permitting him to work reduced hours as an anesthesiologist, and by not employing him in an administrative position due to his disability. ", "The relief sought is compensatory and punitive damages. ", "Currently before the court is defendant's motion for summary judgment pursuant to Rule 56 of the Federal Rules of Civil Procedure. ", "Plaintiff has entered opposition to the motion.", "\n\nDISCUSSION\nRule 56 of the Federal Rules of Civil Procedure permits summary judgment where the evidence demonstrates that \"there is no genuine issue of any material fact and the moving party is entitled to judgment as a matter of law.\" ", "Anderson v. Liberty Lobby, Inc., 477 U.S. 242, 247, 106 S.Ct. ", "2505, 2509, 91 L.Ed.2d 202 (1986). ", "Summary judgment is properly regarded as an integral part of the Federal Rules as a whole, which are designed \"to secure the just, speedy and inexpensive determination of every action.\" ", "Celotex Corp. v. Catrett, 477 U.S. 317, 326, 106 S.Ct. ", "2548, 2554, 91 L.Ed.2d 265 (1991)(quoting Federal Rule of Civil Procedure 1). ", "In determining whether there is a genuine issue of material fact a court must resolve all ambiguities and draw inferences against the moving party. ", "United States v. Diebold, 369 U.S. 654, 655, 82 S.Ct. ", "993, 994, 8 L.Ed.2d 176 (1962)(per curiam). ", "An issue of credibility is insufficient to preclude the granting of summary judgment. ", "Neither side can rely on conelusory *81 allegations or statements in affidavits. ", "The disputed issue of fact must be supported by evidence that would allow a \"rational trier of fact to find for the nonmoving party.\" ", "Matsushita Elec. ", "Indus. ", "Co. v. Zenith Radio Corp., 475 U.S. 574, 587, 106 S.Ct. ", "1348, 1356, 89 L.Ed.2d 538 (1986). ", "Unsupported allegations will not suffice to create a triable issue of fact. ", "Goenaga v. March of Dimes Birth Defects Foundation, 51 F.3d 14, 18 (2d Cir. ", "1995). ", "Nor will factual disputes that are irrelevant to the disposition of the suit under governing law preclude the entry of summary judgment. ", "Anderson, 477 U.S. at 247, 106 S.Ct. ", "at 2509.", "\nSummary judgment is appropriate in discrimination cases for, \"the salutary purposes of summary judgment—avoiding protracted, expensive and harassing trials—apply no less to discrimination cases than to commercial or other areas of litigation.\" ", "Meiri v. Dacon, 759 F.2d 989, 998 (2d Cir.1985). ", "The \"impression that summary judgment is unavailable in discrimination cases is unsupportable.\" ", "McLee v. Chrysler Corp., 38 F.3d 67, 68 (2d Cir. ", "1994). ", "The Supreme Court has also recently reiterated that the trial courts should not \"treat discrimination differently from other ultimate questions of fact.\" ", "Reeves v. Sanderson Plumbing Products, Inc., 530 U.S. 133, 147, 120 S.Ct. ", "2097, 2109, 147 L.Ed.2d 105 (2000)(quoting St. Mary's Honor Center v. Hicks, 509 U.S. 502, 524, 113 S.Ct. ", "2742, 125 L.Ed.2d 407 (1993)). ", "Determination of employment discrimination claims made pursuant to administrative proceedings or contractual grievance processes are not given any preclusive effect under doctrines like res judicata in future suits to redress grievances under Title VII. ", "Hewitt v. Alcan Aluminum Corporation, 185 F.Supp.2d 183, 187 (N.D.N.Y.2001). ", "The remedies in an administrative action or under a grievance procedure are different than those available under Title VII, and, in any event, the federal courts are intended as the final arbiter of rights under Title VII, not administrative agencies or tribunals. ", "Bembry v. Darrow, 97 F.Supp.2d 281, 285 (N.D.N.Y.2000).", "\nThe portion of the ADA applicable to case at bar states that [n]o covered entity shall discriminate against a qualified individual with a disability because of the disability of such individual in regard to ... the discharge of employees ..., 42 U.S.C. § 12112(a). ", "When considering a summary judgment motion in a discriminatory discharge brought under the ADA, the court applies the burden shifting test found in McDonnell Douglas Corp. v. Green, 411 U.S. 792, 802-804, 93 S.Ct. ", "1817, 1824-25, 36 L.Ed.2d 668 (1973). ", "The test is composed of three parts—(1) plaintiff must demonstrate a prima facie of discrimination; (2) if the prima facie case is established, the burden of production shifts to the defendant to articulate a legitimate nondiscriminatory reason for its actions and, (3) if the defendant does so, the presumption created by plaintiffs prima facie case is removed, and the plaintiff then must prove the presence of intentional discrimination by showing by a preponderance of the evidence that the defendant's proffered reasons are only a pretext for the real motivation of discrimination. ", "St. Mary's Honor Center v. Hicks, 509 U.S. 502, 510-11, 113 S.Ct. ", "2742, 2748-49, 125 L.Ed.2d 407 (1993). ", "In order to create a prima facie case of discriminatory discharge under the ADA, a plaintiff must initially show that his employer is subject to the ADA, (2) he suffers from a disability within the meaning of the ADA, (3) he could perform the essential functions of his job with or without accommodation, and (4) he was discharged because of his disability. ", "Reeves v. Johnson Controls World Services, Inc., 140 F.3d 144, 149-150 (2d *82 Cir.1998). ", "An employer is subject to the ADA if it is engaged in an industry affecting commerce and has 15 or more employees for each working day in each of 20 or more calendar weeks in the current or preceding calendar year, 42 U.S.C. §§ 121119(a) and (5)(A). ", "The defendant Group, a private corporation, meets the jurisdictional floor in plaintiffs ADA action.", "\nA disability within the meaning of the ADA is defined as (A) \"a physical or mental impairment that substantially limits one or more of the major life activities of [an] individual; (B) a record of such impairment; or (C) being regarded as having such an impairment.\" ", "42 U.S.C. § 12102(2)(A). ", "There is little doubt that a metastatic islet cell tumor can constitute an impairment. ", "Among its most prominent symptoms are restrictive food intake and, regurgitation thereof, weight loss, liver failure, extensive fatigue, intermittent low blood sugar, hand tremors, gait irregularity, and visual agitations making reading arduous. ", "While the record contains no specific medical substantiated diagnosis of plaintiffs asserted disease, the court will assume that it is evidenced by his request for reduced working hours and/or seeking an administrative position. ", "The question, then, is whether the impairment constitutes a disability under one of the statutory definitions listed above.", "\nTo ascertain if a plaintiff is disabled for the purposes of ADA, three steps are taken, (1) decide if the plaintiff is afflicted with a physical or mental impairment, (2) name the life activity upon which plaintiff relies and confirm whether it is a major life activity under the ADA and, (3) determine if plaintiffs impairment substantially limits the major life activity relied on by plaintiff. ", "Bragdon v. Abbott, 524 U.S. 624, 632-39, 118 S.Ct. ", "2196, 2202-05, 141 L.Ed.2d 540 (1998). ", "Major life activities\nare defined as \"functions such as caring for one's self, performing manual tasks, walking, seeing, hearing, speaking, breathing, learning and working.\" ", "29 C.F.R. 1630.2(i). ", "Plaintiff is physically impaired, and the impairment substantially limits his major life activity of working\nThe reduced hours accommodation claim:\nThis claim was not presented in plaintiffs EEOC complaint and, therefore, cannot be considered by the court unless the continuing violation exception is applicable. ", "West v. Philadelphia Electric Company, 45 F.3d 744 (3rd Cir.1995); LaBeach v. Nestle Co., 658 F.Supp. ", "676, 687 (S.D.N.Y. 1987). ", "Under the continuing violation doctrine, if a plaintiff files a discrimination charge with the EEOC that is timely as to the incident of discrimination in furtherance of an ongoing policy of discrimination, all claims and act of discrimination under that policy will be timely even if they would be untimely standing alone. ", "Lambert v. Genesee Hospital, 10 F.3d 46, 53 (2d Cir.1993). ", "cert, denied 511 U.S. 1052, 114 S.Ct. ", "1612, 128 L.Ed.2d 339 (1994). ", "Although it is a close call in this case, it appears that plaintiffs reduced hours charge would come within the confines of the EEOC's probe and could reasonably be included in the denial of an administrative position discrimination charge.", "\nThe ADA obligates an employer to provide a reasonable accommodation for the limitations arising from an employee's disability. ", "Foreman v. Babcock & Wilcox Company, 117 F.3d 800, 809 (5th Cir.1997). ", "Plaintiff maintains that the Group discriminated against him by refusing to reasonably accommodate him and not permitting him to work without being required to take night call nor provide weekend coverage. ", "These two responsibilities are major functions of his position, and during the nine month accommodation period the Group *83 afforded plaintiff at the North Medical Center, his duties were carried out by other members of the Group, in addition to their own required coverage, without remuneration.", "\n\"Reasonable accommodation\" does not mean elimination of any of the job's essential functions. ", "Gilbert v. Frank, 949 F.2d 637, 644 (2d Cir.1991). ", "Night call and weekend coverage are essential functions of' plaintiffs employment. ", "The record does not show otherwise. ", "Nothing in the ADA indicates that in enacting this legislation, Congress intended to interfere with personnel decisions within an organizational hierarchy. ", "Congress intended simply to show that disabled persons have the same opportunities available to them as are available to non-disabled person. ", "The defendant Group did not have an affirmative duty to provide plaintiff with a position for which he was qualified; the Group only had an obligation to treat him in the same manner that it treated other similarly qualified personnel. ", "School Board v. Arline, 480 U.S. 273, 289 n. 19, 107 S.Ct. ", "1123, 1131 n. 19, 94 L.Ed.2d 307 (1987); Bates v. Long Island Railroad Company, 997 F.2d 1028, 1035-36 (2d Cir.), ", "cert, denied, 510 U.S. 992, 114 S.Ct. ", "550, 126 L.Ed.2d 452 (1993). ", "Furthermore, granting plaintiffs request for exemption from night call and weekend coverage would require the Group to relocate job duties to other employees in order to change essential functions of the position. ", "Milton v. Scrivner, Inc., 53 F.3d 1118, 1124 (10th Cir.1995); 29 C.F.R. § 1630.2(o). ", "An accommodation that would result in other employees having to work harder or longer is not required under the ADA. ", "Id. at 1125, 1129 C.F.R. § 1630.2(p)(2)(v). ", "This, in turn, would impact on the ability of other employees to perform their duties and on the ability of the Group to properly serve its patients. ", "Id. Such accommodation would place an undue hardship burden on the Group and is not mandated by the ADA.", "\n\nThe administrative position claim:\nWhen a Group member proposed that plaintiff be given the position of billing office manager at the Group's Board of Director's meeting, no such position was extant. ", "In June 1999, Monte Priebe had vacated his position as Executive Practice Administrator for the Group. ", "He was a full time employee receiving an annual salary of $125,000, and his job included many more aspects of health care financing than simply running the billing office.", "\nIn July 1999, the Group decided it did not need a full time Executive Practice Administrator, because the billing office was running well and they were dissatisfied with Mr. Priebe's work. ", "Instead, the Group decided to retain Dermody, Burke & Brown, CPA, PC, to provide occasional consulting work for the Group on an asneeded basis on such issues as their party reimbursement, claims processing, systems operations and personnel in the billing office. ", "No written contract was entered between the parties. ", "The Dermody firm was to be paid between $150 and $185 per hour, with a $5,000 per month cap. ", "William J. Kilroy, CPA, a health care financial specialist, provided consultation services to the Group from July 1999 until August 2001, when the parties mutually agreed to terminate the arrangement. ", "The position of Executive Administrator was never filled by the Group, and it did not create a position of business manager or business consultant.", "\nThe supposed office of billing officer manager was never filled, and the ADA does not require an employer to create a new position to accommodate a disabled employee. ", "Jackson v. Analysts International Corp., 956 F.Supp. ", "1568 (D.Kan. ", "1997), affd. ", "134 F.3d 382 (10th Cir.1998), *84 and the statute does not obligate an employer to provide a disabled employee with every accommodation on his wish list. ", "Stewart v. County of Brown, 86 F.3d 107, 111-12 (7th Cir.1996).", "\nThe defendant Group has provided legitimate explanationsions for the events that took place. ", "Faced with these explanations, plaintiff must produce evidence to support a finding that they are a pretext. ", "Plaintiff has not done so and, thus, has not established a prima facie case of disability discrimination.", "\nThe court declines to exercise pendant jurisdiction over plaintiffs state law claims under the New York Human Rights Law and the New York state common law claim of prima facie tort. ", "When the federal law claims have been dropped out of the lawsuit in its early stages and only state law claims remain, the federal court should decline to exercise pendant jurisdiction by dismissing the .case without prejudice. ", "This judgment will not foreclose plaintiffs pursuit of his state law claims in state court. ", "Buckley v. Consolidated Edison Company of New York, 155 F.3d 150, 157 (2d Cir.1998).", "\nAccordingly, defendant's motion for summary judgment is GRANTED with prejudice as to plaintiffs claims under the ADA, plaintiffs state law claims are dismissed without prejudice.", "\nIT IS SO ORDERED.", "\n" ]

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[ "Month: May 2005\n\nYour #1 Match: ISFJ The NurturerYou have a strong need to belong, and you very loyal.", "A good listener, you excell at helping others in practical ways.", "In your spare time, you enjoy engaging your senses through art, cooking, and music.", "You find it easy to be devoted to one person, who you do special things for.", "You would make a good interior designer, chef, or child psychologist. ", "Your #2 Match: INFJ The ProtectorYou live your life with integrity, originality, vision, and creativity.", "Independent and stubborn, you rarely stray from your vision – no matter what it is.", "You are an excellent listener, with almost infinite patience.", "You have complex, deep feelings, and you take great care to express them.", "You would make a great photographer, alternative medicine guru, or teacher. ", "Your #3 Match: ISTJ The Duty FulfillerYou are responsible, reliable, and hardworking – you get the job done.", "You prefer productive hobbies, like woodworking or knittings.", "Quiet and serious, you are well prepared for whatever life hands you.", "Conservative and down-to-earth, you hardly ever do anything crazy.", "You would make a great business executive, accountant, or …\n\nRate this:\n\nhaha back to bloggin again.. shall start off from the project superstar thingy.. was having a bad flu since tuesday.. and my audition was on saturday.. pray damm hard that my flu will recover by sat but it failed… but, i still went for it.. queue up for some time before we got allocated to the different rooms for audition.. my judges was Yes933 DJ, Chong Qing , Chairman of Yes933 and a gal whom i dunnoe who she is.. the moment i step into the room, i greeted the judges.. then chong qing ask me: “r u having a flu?”, “", "Ya,” “then u jin liang ba..”.. then i told him i’m going to sing kiss noht form wilber pan.. he then ask me if i can add in some actions.. but i told him the song i singing not those rap song from wilber so dun expect to have lots of actions.. he sya ok.. while singing, the chairman and chong qin nodded their head.. i was quite happy.. they let me finish the …\n\nRate this:\n\nRate this:\n\nHello to all the\n\n1,229,504 Visitors\n\nDarren Profile 達人資料庫\n\nHello! ", "I'm darren, a lifestyle singapore male blogger that basically blogs about everything under the sun. ", "Read on and follow me on my social media channels and i hope you will learn, enjoy and love this humble blog of mine :)\n\nAdvertising & Sponsorship Enquires\n\nFor advertising and sponsorship enquires, kindly drop me an email at darren862@gmail.com and I will get back to you as soon as possible.", "\nCurrently keen in COLLABORATION for\n* Travel Trips\n* Hotel Stays\n* Grooming Related\n* Slimming\n* Invisalign\n* Basically anything!" ]

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[ "Q:\n\nC# await async not working\n\nI have a button that does the following:\nprivate void button3_Click_1(object sender, EventArgs e)\n{\ndoStuff();\n}\n\nHere is my doStuff function:\nprivate async Task doStuff()\n{\nvar nat = new NatDiscoverer();\n\n// we don't want to discover forever, just 5 senconds or less\nvar cts = new CancellationTokenSource(5000);\nvar device = await nat.", "DiscoverDeviceAsync(PortMapper.", "Upnp, cts); \n}\n\nInitially I was getting an error but it was because I didn't have the \"async Task\" in the doStuff() function.", "\nCurrently I don't have red lines anymore but I do have the green lines under the button3_Click event for the function doStuff();\nIt says to consider adding \"await\" but if I add await in front of doStuff() I get an error.", "\nAm I using this await correctly? ", "How do I get this to work properly?", "\nI'm using the Open.", "NAT dll just trying to list the open ports.", "\nThe warning I'm getting is:\nConsider adding the \"await\" operator to the rest of the call\nThanks,\n\nA:\n\nmake your button click method async and await your call\nprivate async void button3_Click_1(object sender, EventArgs e)\n{\n await doStuff();\n}\n\n" ]

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[ "Low-dose doxorubicin in the management of advanced carcinoma of the prostate.", "\nTwenty-one patients with advanced metastatic carcinoma of the prostate, no longer responsive to conventional therapy, were treated with weekly low-dose doxorubicin (Adriamycin). ", "Twelve had an impressive subjective response in terms of pain relief and improved performance status and in nine this was maintained for 3 or more months." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "Mytrip App\n\nHey guys!", "\nThis app can help us choose or switch lanes if you are new in town or a beginner driver. ", "Also uses recommendation system for choosing the easiest or the fastest route.", "\nHere you can download it." ]

{ "pile_set_name": "Pile-CC" }

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[ "I have revised the relevant experience paragraph slightly (if you open the \nattachment using \"Launch\" you can see the changes highlighted). ", " Kim, if this \nis OK with you please go ahead and use it.", "\n\n\n\n\n\nRichard B Sanders\n12/02/98 08:17 AM\nTo: Mark - ECT Legal Taylor/HOU/ECT@ECT\ncc: Kimberly B Dees/HOU/ECT@ECT \nSubject: Position Description\n\nPlease review and let Kim know if you have any corrections\n---------------------- Forwarded by Richard B Sanders/HOU/ECT on 12/02/98 \n08:10 AM ---------------------------\nTo: Richard B Sanders/HOU/ECT@ECT\ncc: Cindy Skinner/HOU/ECT@ECT \nSubject: Position Description\n\nPlease review the attached description. ", " Per my voicemail I would like to \nhave it posted on the Texas Lawyer website. ", " This is a free site for \nemployers. ", " Please send me back any changes or comments." ]

{ "pile_set_name": "Enron Emails" }

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[ "Jeff Golden\n\nJeffrey Simon Golden (born April 24, 1950) is a political activist, radio personality, politician and author from Southern Oregon. ", "His commentary and political leaning are progressive. ", "He is the producer and host of the regional PBS series Immense Possibilities. ", "In 2018, he was elected to the Oregon State Senate, representing District 3.", "\n\nPersonal background\nGolden was born in Los Angeles, California, the second of four children born to Lane and Jack Golden. ", "His siblings include KC Golden, Policy Director for the Seattle based Climate Change Advocacy group Climate Solutions; Michael Golden, a tribal judge in Humboldt County, California; and Jesse Golden. ", "Jeff grew up in Beverly Hills, California, and graduated from Beverly Hills High School in 1968 as the Student Body President and at the top of his class.", "\n\nGolden attended Harvard as a Harvard National Scholar, a scholarship program established in honor of Harvard’s 300th anniversary with the goal of encouraging and enabling a small number of the best students from across the nation to attend the university. ", "At college, Golden was active in efforts in opposition to the Vietnam War. ", "In May 1970, he tried to join the Venceremos Brigade, but was turned down. ", "Instead, Golden volunteered with northern students to support the work of Featherfield Farm, the first ever sharecroppers' cooperative, created under the Georgia Council on Human Relations in Southwest Georgia. ", "The experience inspired Golden to leave Harvard and try to build a sustainable life on a plot of land in rural Southern Oregon, an experience chronicled in Golden's first published book, Watermelon Summer: A Journal.", "\n\nIn the early 1970s, Golden worked as a river guide for American River Touring Association. ", "Golden and his then girlfriend Catherine Shaw were featured in the 1978 documentary film Riverdogs by fellow Harvard alumnus Robb Moss. ", "The film followed 17 people on a month-long rafting trip down the Colorado River. ", "The couple were married the next year.", "\n\nIn 1980, Golden was accepted into the Stanford University’s Broadcast Communications master's program after publishing Watermelon Summer, an essay about his life in the 1970s. ", "The couple had two children before divorcing in 1994, and Shaw went on to have a career as a politician and political consultant. ", "Both appeared in the 2003 documentary film The Same River Twice, a follow-up to Riverdogs.", "\n\nRadio career\nJeff Golden has spent 25 years in public broadcasting, print journalism, politics, and mediation. ", "For 10 years, he was the host for National Public Radio’s show Jefferson Exchange, from 1997-2007. ", "This award-winning daily talk and interview program aired on NPR’s largest regional network in Southern Oregon and Northern California.", "\n\nThe show was described by the website as a \"lively two-hour interactive program devoted to issues facing the State of Jefferson, the Northwest, the nation and the world. ", "In the first hour, Jeff trades views with callers on a wide range of topics. ", "In hour two, fascinating guests join in the discussion.\"", "\n\nGolden left the radio show in June 2007 to explore a candidacy for the United States Senate in the 2008 election. ", "After opting to not run in August 2007, he started a new independent radio program called Immense Possibilities Radio (IPR). ", "The purpose behind IPR, as describe by PERC.org, is to \"strengthen civic involvement and harness the power of talk radio for quality, open-minded dialogue. ", "By bringing individuals together on the air, Golden wants to minimize conflicts over ideology and focus on ‘what works.’\"", "\n\nPolitical career\nGolden served as County Commissioner for Jackson County, Oregon from 1987-1991. ", "During this time, he became involved in the spotted owl controversy and petitions for his recall circulated among logging advocacy groups. ", "One result in the wake of the controversy was his nomination for the John F. Kennedy Library Foundation Profile and Courage award, the nation's most prestigious honor for elected public servants Golden was the first nominee from Oregon.", "\n\nIn 1990, after narrowly losing to fourth-term Republican incumbent Lenn Hannon for a seat in the State Senate, Golden took the position of Bill Bradbury’s Chief of Staff in 1993. ", "Bradbury was President of the Oregon Senate at the time.", "\n\nIn July, 2007, Golden announced his intention to run against Gordon Smith for the US Senate seat for Oregon. ", "Golden stepped out of the election in August, 2007.", "\n\nWorks\n\nBooks\nWatermelon Summer: A Journal Published (1971) - an account of Golden’s decision to drop out of Harvard and live off-the-grid in rural Southern Oregon. ()", "\nForest Blood (1999) - a novel about the Northwest timber wars challenging the dichotomy of \"us versus them\" between the environmentalists and loggers in Southern Oregon. ()", "\nAs If We Were Grownups: A Collection of \"Suicidal\" Political Speeches That Aren’t (2004) - is based on the premise that politicians address the American public as though they were children and is a collection of speeches that are addressed to an audience that would be the least likely to want to hear them. ()", "\nUnafraid: A Novel of the Possible - an alternate history premised on John F. Kennedy surviving the assassination attempt in Dallas and serving two full terms. ()", "\n\nFilmography\nRiverdogs (1978) - documentary following 16 hippies for a month-long rafting trip down the Colorado River.", "\nThe Same River Twice (2003) - a follow-up documentary on the lives of the cast in Riverdogs\n\nExternal links \n Campaign website\n Legislative website\n\nReferences\n\nCategory:County commissioners in Oregon\nCategory:Radio personalities from Oregon\nCategory:Politicians from Los Angeles\nCategory:1950 births\nCategory:Harvard University alumni\nCategory:Living people\nCategory:People from Jackson County, Oregon" ]

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[ "/*\n * Copyright (c) 2000-2010 LSI Corporation.", "\n *\n *\n * Name: mpi2_tool.h\n * Title: MPI diagnostic tool structures and definitions\n * Creation Date: March 26, 2007\n *\n * mpi2_tool.h Version: 02.00.06\n *\n * Version History\n * ---------------\n *\n * Date Version Description\n * -------- -------- ------------------------------------------------------\n * 04-30-07 02.00.00 Corresponds to Fusion-MPT MPI Specification Rev A.\n * 12-18-07 02.00.01 Added Diagnostic Buffer Post and Diagnostic Release\n * structures and defines.", "\n * 02-29-08 02.00.02 Modified various names to make them 32-character unique.", "\n * 05-06-09 02.00.03 Added ISTWI Read Write Tool and Diagnostic CLI Tool.", "\n * 07-30-09 02.00.04 Added ExtendedType field to DiagnosticBufferPost request\n * and reply messages.", "\n * Added MPI2_DIAG_BUF_TYPE_EXTENDED.", "\n * Incremented MPI2_DIAG_BUF_TYPE_COUNT.", "\n * 05-12-10 02.00.05 Added Diagnostic Data Upload tool.", "\n * 08-11-10 02.00.06 Added defines that were missing for Diagnostic Buffer\n * Post Request.", "\n * --------------------------------------------------------------------------\n */\n\n#ifndef MPI2_TOOL_H\n#define MPI2_TOOL_H\n\n/*****************************************************************************\n*\n* Toolbox Messages\n*\n*****************************************************************************/\n\n/* defines for the Tools */\n#define MPI2_TOOLBOX_CLEAN_TOOL (0x00)\n#define MPI2_TOOLBOX_MEMORY_MOVE_TOOL (0x01)\n#define MPI2_TOOLBOX_DIAG_DATA_UPLOAD_TOOL (0x02)\n#define MPI2_TOOLBOX_ISTWI_READ_WRITE_TOOL (0x03)\n#define MPI2_TOOLBOX_BEACON_TOOL (0x05)\n#define MPI2_TOOLBOX_DIAGNOSTIC_CLI_TOOL (0x06)\n\n\n/****************************************************************************\n* Toolbox reply\n****************************************************************************/\n\ntypedef struct _MPI2_TOOLBOX_REPLY\n{\n U8 Tool; /* 0x00 */\n U8 Reserved1; /* 0x01 */\n U8 MsgLength; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U16 Reserved5; /* 0x0C */\n U16 IOCStatus; /* 0x0E */\n U32 IOCLogInfo; /* 0x10 */\n} MPI2_TOOLBOX_REPLY, MPI2_POINTER PTR_MPI2_TOOLBOX_REPLY,\n Mpi2ToolboxReply_t, MPI2_POINTER pMpi2ToolboxReply_t;\n\n\n/****************************************************************************\n* Toolbox Clean Tool request\n****************************************************************************/\n\ntypedef struct _MPI2_TOOLBOX_CLEAN_REQUEST\n{\n U8 Tool; /* 0x00 */\n U8 Reserved1; /* 0x01 */\n U8 ChainOffset; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U32 Flags; /* 0x0C */\n } MPI2_TOOLBOX_CLEAN_REQUEST, MPI2_POINTER PTR_MPI2_TOOLBOX_CLEAN_REQUEST,\n Mpi2ToolboxCleanRequest_t, MPI2_POINTER pMpi2ToolboxCleanRequest_t;\n\n/* values for the Flags field */\n#define MPI2_TOOLBOX_CLEAN_BOOT_SERVICES (0x80000000)\n#define MPI2_TOOLBOX_CLEAN_PERSIST_MANUFACT_PAGES (0x40000000)\n#define MPI2_TOOLBOX_CLEAN_OTHER_PERSIST_PAGES (0x20000000)\n#define MPI2_TOOLBOX_CLEAN_FW_CURRENT (0x10000000)\n#define MPI2_TOOLBOX_CLEAN_FW_BACKUP (0x08000000)\n#define MPI2_TOOLBOX_CLEAN_MEGARAID (0x02000000)\n#define MPI2_TOOLBOX_CLEAN_INITIALIZATION (0x01000000)\n#define MPI2_TOOLBOX_CLEAN_FLASH (0x00000004)\n#define MPI2_TOOLBOX_CLEAN_SEEPROM (0x00000002)\n#define MPI2_TOOLBOX_CLEAN_NVSRAM (0x00000001)\n\n\n/****************************************************************************\n* Toolbox Memory Move request\n****************************************************************************/\n\ntypedef struct _MPI2_TOOLBOX_MEM_MOVE_REQUEST {\n U8 Tool; /* 0x00 */\n U8 Reserved1; /* 0x01 */\n U8 ChainOffset; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n MPI2_SGE_SIMPLE_UNION SGL; /* 0x0C */\n} MPI2_TOOLBOX_MEM_MOVE_REQUEST, MPI2_POINTER PTR_MPI2_TOOLBOX_MEM_MOVE_REQUEST,\n Mpi2ToolboxMemMoveRequest_t, MPI2_POINTER pMpi2ToolboxMemMoveRequest_t;\n\n\n/****************************************************************************\n* Toolbox Diagnostic Data Upload request\n****************************************************************************/\n\ntypedef struct _MPI2_TOOLBOX_DIAG_DATA_UPLOAD_REQUEST {\n\tU8 Tool; /* 0x00 */\n\tU8 Reserved1; /* 0x01 */\n\tU8 ChainOffset; /* 0x02 */\n\tU8 Function; /* 0x03 */\n\tU16 Reserved2; /* 0x04 */\n\tU8 Reserved3; /* 0x06 */\n\tU8 MsgFlags; /* 0x07 */\n\tU8 VP_ID; /* 0x08 */\n\tU8 VF_ID; /* 0x09 */\n\tU16 Reserved4; /* 0x0A */\n\tU8 SGLFlags; /* 0x0C */\n\tU8 Reserved5; /* 0x0D */\n\tU16 Reserved6; /* 0x0E */\n\tU32 Flags; /* 0x10 */\n\tU32 DataLength; /* 0x14 */\n\tMPI2_SGE_SIMPLE_UNION SGL; /* 0x18 */\n} MPI2_TOOLBOX_DIAG_DATA_UPLOAD_REQUEST,\nMPI2_POINTER PTR_MPI2_TOOLBOX_DIAG_DATA_UPLOAD_REQUEST,\nMpi2ToolboxDiagDataUploadRequest_t,\nMPI2_POINTER pMpi2ToolboxDiagDataUploadRequest_t;\n\n/* use MPI2_SGLFLAGS_ defines from mpi2.h for the SGLFlags field */\n\n\ntypedef struct _MPI2_DIAG_DATA_UPLOAD_HEADER {\n\tU32 DiagDataLength; /* 00h */\n\tU8 FormatCode; /* 04h */\n\tU8 Reserved1; /* 05h */\n\tU16 Reserved2; /* 06h */\n} MPI2_DIAG_DATA_UPLOAD_HEADER, MPI2_POINTER PTR_MPI2_DIAG_DATA_UPLOAD_HEADER,\nMpi2DiagDataUploadHeader_t, MPI2_POINTER pMpi2DiagDataUploadHeader_t;\n\n\n/****************************************************************************\n* Toolbox ISTWI Read Write Tool\n****************************************************************************/\n\n/* Toolbox ISTWI Read Write Tool request message */\ntypedef struct _MPI2_TOOLBOX_ISTWI_READ_WRITE_REQUEST {\n U8 Tool; /* 0x00 */\n U8 Reserved1; /* 0x01 */\n U8 ChainOffset; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U32 Reserved5; /* 0x0C */\n U32 Reserved6; /* 0x10 */\n U8 DevIndex; /* 0x14 */\n U8 Action; /* 0x15 */\n U8 SGLFlags; /* 0x16 */\n U8 Reserved7; /* 0x17 */\n U16 TxDataLength; /* 0x18 */\n U16 RxDataLength; /* 0x1A */\n U32 Reserved8; /* 0x1C */\n U32 Reserved9; /* 0x20 */\n U32 Reserved10; /* 0x24 */\n U32 Reserved11; /* 0x28 */\n U32 Reserved12; /* 0x2C */\n MPI2_SGE_SIMPLE_UNION SGL; /* 0x30 */\n} MPI2_TOOLBOX_ISTWI_READ_WRITE_REQUEST,\n MPI2_POINTER PTR_MPI2_TOOLBOX_ISTWI_READ_WRITE_REQUEST,\n Mpi2ToolboxIstwiReadWriteRequest_t,\n MPI2_POINTER pMpi2ToolboxIstwiReadWriteRequest_t;\n\n/* values for the Action field */\n#define MPI2_TOOL_ISTWI_ACTION_READ_DATA (0x01)\n#define MPI2_TOOL_ISTWI_ACTION_WRITE_DATA (0x02)\n#define MPI2_TOOL_ISTWI_ACTION_SEQUENCE (0x03)\n#define MPI2_TOOL_ISTWI_ACTION_RESERVE_BUS (0x10)\n#define MPI2_TOOL_ISTWI_ACTION_RELEASE_BUS (0x11)\n#define MPI2_TOOL_ISTWI_ACTION_RESET (0x12)\n\n/* use MPI2_SGLFLAGS_ defines from mpi2.h for the SGLFlags field */\n\n\n/* Toolbox ISTWI Read Write Tool reply message */\ntypedef struct _MPI2_TOOLBOX_ISTWI_REPLY {\n U8 Tool; /* 0x00 */\n U8 Reserved1; /* 0x01 */\n U8 MsgLength; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U16 Reserved5; /* 0x0C */\n U16 IOCStatus; /* 0x0E */\n U32 IOCLogInfo; /* 0x10 */\n U8 DevIndex; /* 0x14 */\n U8 Action; /* 0x15 */\n U8 IstwiStatus; /* 0x16 */\n U8 Reserved6; /* 0x17 */\n U16 TxDataCount; /* 0x18 */\n U16 RxDataCount; /* 0x1A */\n} MPI2_TOOLBOX_ISTWI_REPLY, MPI2_POINTER PTR_MPI2_TOOLBOX_ISTWI_REPLY,\n Mpi2ToolboxIstwiReply_t, MPI2_POINTER pMpi2ToolboxIstwiReply_t;\n\n\n/****************************************************************************\n* Toolbox Beacon Tool request\n****************************************************************************/\n\ntypedef struct _MPI2_TOOLBOX_BEACON_REQUEST\n{\n U8 Tool; /* 0x00 */\n U8 Reserved1; /* 0x01 */\n U8 ChainOffset; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U8 Reserved5; /* 0x0C */\n U8 PhysicalPort; /* 0x0D */\n U8 Reserved6; /* 0x0E */\n U8 Flags; /* 0x0F */\n} MPI2_TOOLBOX_BEACON_REQUEST, MPI2_POINTER PTR_MPI2_TOOLBOX_BEACON_REQUEST,\n Mpi2ToolboxBeaconRequest_t, MPI2_POINTER pMpi2ToolboxBeaconRequest_t;\n\n/* values for the Flags field */\n#define MPI2_TOOLBOX_FLAGS_BEACONMODE_OFF (0x00)\n#define MPI2_TOOLBOX_FLAGS_BEACONMODE_ON (0x01)\n\n\n/****************************************************************************\n* Toolbox Diagnostic CLI Tool\n****************************************************************************/\n\n#define MPI2_TOOLBOX_DIAG_CLI_CMD_LENGTH (0x5C)\n\n/* Toolbox Diagnostic CLI Tool request message */\ntypedef struct _MPI2_TOOLBOX_DIAGNOSTIC_CLI_REQUEST {\n U8 Tool; /* 0x00 */\n U8 Reserved1; /* 0x01 */\n U8 ChainOffset; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U8 SGLFlags; /* 0x0C */\n U8 Reserved5; /* 0x0D */\n U16 Reserved6; /* 0x0E */\n U32 DataLength; /* 0x10 */\n U8 DiagnosticCliCommand\n\t\t[MPI2_TOOLBOX_DIAG_CLI_CMD_LENGTH]; /* 0x14 */\n MPI2_SGE_SIMPLE_UNION SGL; /* 0x70 */\n} MPI2_TOOLBOX_DIAGNOSTIC_CLI_REQUEST,\n MPI2_POINTER PTR_MPI2_TOOLBOX_DIAGNOSTIC_CLI_REQUEST,\n Mpi2ToolboxDiagnosticCliRequest_t,\n MPI2_POINTER pMpi2ToolboxDiagnosticCliRequest_t;\n\n/* use MPI2_SGLFLAGS_ defines from mpi2.h for the SGLFlags field */\n\n\n/* Toolbox Diagnostic CLI Tool reply message */\ntypedef struct _MPI2_TOOLBOX_DIAGNOSTIC_CLI_REPLY {\n U8 Tool; /* 0x00 */\n U8 Reserved1; /* 0x01 */\n U8 MsgLength; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U16 Reserved5; /* 0x0C */\n U16 IOCStatus; /* 0x0E */\n U32 IOCLogInfo; /* 0x10 */\n U32 ReturnedDataLength; /* 0x14 */\n} MPI2_TOOLBOX_DIAGNOSTIC_CLI_REPLY,\n MPI2_POINTER PTR_MPI2_TOOLBOX_DIAG_CLI_REPLY,\n Mpi2ToolboxDiagnosticCliReply_t,\n MPI2_POINTER pMpi2ToolboxDiagnosticCliReply_t;\n\n\n/*****************************************************************************\n*\n* Diagnostic Buffer Messages\n*\n*****************************************************************************/\n\n\n/****************************************************************************\n* Diagnostic Buffer Post request\n****************************************************************************/\n\ntypedef struct _MPI2_DIAG_BUFFER_POST_REQUEST\n{\n U8 ExtendedType; /* 0x00 */\n U8 BufferType; /* 0x01 */\n U8 ChainOffset; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U64 BufferAddress; /* 0x0C */\n U32 BufferLength; /* 0x14 */\n U32 Reserved5; /* 0x18 */\n U32 Reserved6; /* 0x1C */\n U32 Flags; /* 0x20 */\n U32 ProductSpecific[23]; /* 0x24 */\n} MPI2_DIAG_BUFFER_POST_REQUEST, MPI2_POINTER PTR_MPI2_DIAG_BUFFER_POST_REQUEST,\n Mpi2DiagBufferPostRequest_t, MPI2_POINTER pMpi2DiagBufferPostRequest_t;\n\n/* values for the ExtendedType field */\n#define MPI2_DIAG_EXTENDED_TYPE_UTILIZATION (0x02)\n\n/* values for the BufferType field */\n#define MPI2_DIAG_BUF_TYPE_TRACE (0x00)\n#define MPI2_DIAG_BUF_TYPE_SNAPSHOT (0x01)\n#define MPI2_DIAG_BUF_TYPE_EXTENDED (0x02)\n/* count of the number of buffer types */\n#define MPI2_DIAG_BUF_TYPE_COUNT (0x03)\n\n/* values for the Flags field */\n#define MPI2_DIAG_BUF_FLAG_RELEASE_ON_FULL (0x00000002)\n#define MPI2_DIAG_BUF_FLAG_IMMEDIATE_RELEASE (0x00000001)\n\n\n/****************************************************************************\n* Diagnostic Buffer Post reply\n****************************************************************************/\n\ntypedef struct _MPI2_DIAG_BUFFER_POST_REPLY\n{\n U8 ExtendedType; /* 0x00 */\n U8 BufferType; /* 0x01 */\n U8 MsgLength; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U16 Reserved5; /* 0x0C */\n U16 IOCStatus; /* 0x0E */\n U32 IOCLogInfo; /* 0x10 */\n U32 TransferLength; /* 0x14 */\n} MPI2_DIAG_BUFFER_POST_REPLY, MPI2_POINTER PTR_MPI2_DIAG_BUFFER_POST_REPLY,\n Mpi2DiagBufferPostReply_t, MPI2_POINTER pMpi2DiagBufferPostReply_t;\n\n\n/****************************************************************************\n* Diagnostic Release request\n****************************************************************************/\n\ntypedef struct _MPI2_DIAG_RELEASE_REQUEST\n{\n U8 Reserved1; /* 0x00 */\n U8 BufferType; /* 0x01 */\n U8 ChainOffset; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n} MPI2_DIAG_RELEASE_REQUEST, MPI2_POINTER PTR_MPI2_DIAG_RELEASE_REQUEST,\n Mpi2DiagReleaseRequest_t, MPI2_POINTER pMpi2DiagReleaseRequest_t;\n\n\n/****************************************************************************\n* Diagnostic Buffer Post reply\n****************************************************************************/\n\ntypedef struct _MPI2_DIAG_RELEASE_REPLY\n{\n U8 Reserved1; /* 0x00 */\n U8 BufferType; /* 0x01 */\n U8 MsgLength; /* 0x02 */\n U8 Function; /* 0x03 */\n U16 Reserved2; /* 0x04 */\n U8 Reserved3; /* 0x06 */\n U8 MsgFlags; /* 0x07 */\n U8 VP_ID; /* 0x08 */\n U8 VF_ID; /* 0x09 */\n U16 Reserved4; /* 0x0A */\n U16 Reserved5; /* 0x0C */\n U16 IOCStatus; /* 0x0E */\n U32 IOCLogInfo; /* 0x10 */\n} MPI2_DIAG_RELEASE_REPLY, MPI2_POINTER PTR_MPI2_DIAG_RELEASE_REPLY,\n Mpi2DiagReleaseReply_t, MPI2_POINTER pMpi2DiagReleaseReply_t;\n\n\n#endif\n\n" ]

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[ "“Expert: a man who makes three correct guesses consecutively. “ – ", "Laurence J. Peter\n\nAs a teenager I was an anarchist. ", "While I wasn’t particularity good it it, most of my time was spent smoking and writing bad poetry, I did have an epiphany that changed my life. ", "Most of the people who tried telling me what to do had no real authority over me. ", "If I followed their advice I’d be in the exact same position as them.", "\n\nI’ve followed that philosophy ever since. ", "It’s saved me from wasting a lot of time and anger. ", "If I won’t want something someone else has, I disregard their advice.", "\n\nBack in college I had a children’s literature professor who made every single assignment into a crusade about how classic stories were sexist. ", "I did the work, turned in the assignments on time, and never bothered to take any of seriously. ", "If I wanted to grow up and become a frumpy dork in an ill fitting sweater, I’d have absorbed every word. ", "Since that wasn’t something that interested me, I paid zero attention to any of the lessons.", "\n\nWhile this might sound obvious, the vast majority of people never seem to pick up on it.", "\n\nIf you want to be like someone else, follow their advice . ", "Otherwise go seek out a better source.", "\n\nShare this: Facebook\n\nTwitter\n\nTumblr\n\n" ]

{ "pile_set_name": "OpenWebText2" }

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[ "WHAT THIS PRODUCT DOESCreate a wired network in your home using the TP-LINK 8-Port Cable/DSL Router (TL-R860). ", "Connect this Wired Router to a broadband modem and share your high-speed Internet access, check email, share files, and enjoy online gaming. ", "With the Easy Setup Assistant, you can easily build a wired network and share your high speed internet connection with all the PCs connected to surf the internet, chat online and check mails.", "\n\nShare Resources and Simplify the NetworkThe built-in 8-port switch provides computers on the LAN with network connectivity and Internet access. ", "Connect up to four PCs or other networking devices to access home or office resources and use the Internet. ", "Switching capabilities have been integrated into this device to efficiently manage your network traffic.", "\n\nNetwork Security ProtectionTL-R860 includes a built-in strong firewall for safeguarding your network from hackers and malicious attacks from across the Internet, such as DoS attack, ARP virus attack, etc. ", "For added convenience, it supports access control based on the time of day, MAC address, IP address, or domain name. ", "So parents and network administrators can establish restricted access policies for children or staff.", "\n\nBandwidth ManagementTL-R860 supports intelligent IP QoS for bandwidth management, which allows administrators to determine how much bandwidth is allotted to each PC. ", "This ensures that those programs such as VoIP or video application that are sensitive to lag are given as much bandwidth as possible to avoid lag the performance.", "\n\nParents Control The TL-R860 router provides flexible access control, limiting staff or children to browse selected sites, which keep your kid’s online experience safer and more fun. ", "Lets you customize setting by device, and even limit online time and block specific sites.", "\n\nEasy to UseThe device comes with a CD with an Easy Setup Assistant that helps you step by step to configure your Internet connection. ", "This feature allows even novice users to setup the router products without sacrificing any key features, just play the AUTO-RUN CD bundled to have your network set up quickly & hassle-free." ]

{ "pile_set_name": "Pile-CC" }

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[ "Thursday, November 22, 2012\n\nThe One with Pierced Ears\n\nWhen I was 10 years old I kept my room clean for an entire year - my incentive was getting my ears pierced. ", "At long last the year was up and we were in Utah for vacation visiting my cousins, Maren (then 7 years old) and Sara Jayne (6). ", "We made our way to the Claire's at the ZCMI Center Mall (which was torn down in 2007 and is now City Creek Center, FYI.) ", "I gripped my mother's arm as the needle pierced through my flesh, leaving a little gold stud. ", "Then Maren got her ears pierced and then my mom got her 2nd earholes pierced - later which she would remove after President Hinckley's suggestion. ", "Once we got back to Maren and Sara Jayne's, Sara Jayne was so sad that she didn't get her ears pierced that we turned around and marched right back to the mall to get her ears bejeweled too. ", "We kept Claire's in business that day!", "\n\nOh how much fun I had once the wound had healed switching out my earrings every day! ", "One of the best things about being a girl is accessorizing and earrings were muy importante. ", "Over the years the styles of earrings changed - big hoops, small hoops, chandelier style, wood, acrylic flowers, feathers - you name it, I probably had a pair.", "\n\nAnd then out of nowhere in 2007 my ears became allergic to anything but pure gold! ", "How does that even happen? ", "So basically I have an entire collection of earrings that I can't wear anymore and here they've hung for the past 5 years, all but forgotten.", "\n\nAre earrings not in style these days? ", "I haven't been paying attention! ", "But I'm going to start looking around because it'd be fun to once again take advantage of the holes in my ears. ", "Maybe I'll get the courage to try a different, more outlandish pair tomorrow and see if I'm still allergic.", "\n\n10 comments:\n\nOMG! ", "I am allergic too...but I have been ever since I can remember. ", "Any jewelry that is not of the highest quality has me breaking out in a rash, swelling up, or whatever...I have tried nickel free products but it doesn't seem to fix anything. ", "Let me know if you find anything that works!", "\n\nSome people can paint their earrings with clear nail polish and that will keep them from reacting the the fake earrings. ", "I used to work at Claire's and that was a tip I learned. ", "I don't think it would work on everyone and you probably have to repaint every time.", "\n\nBummer you can't wear your old ones anymore! ", "I think the little studs you have on are cute!!! ", "I haven't worn earrings in YEARS ... cuz I am always wearing my hair down, so you can't see them anyways! ", "LOL! ", "Happy Thanksgiving!!", "\n\nI'm so mad because I got my ears pierced when I was 8 but for some reason my ears started getting really infected every time I would wear earrings on one side so I just stopped wearing them for the past few months. ", "I really didn't even notice, and I feel like people really don't wear them that often anymore anyway. ", "But I went to try and put my earrings in and it wouldn't go all the way through. ", "I'm so sad. ", "Hoping the swelling just has to go down and it will work again! ", "Fingers crossed!!", "\n\nI love earrings. ", "I wear diamond studs every day. ", "They are small in simple but can really class you up if you choose not to wear other jewelry. ", "I'm the same way though my ears don't like the earrings with nickel in them. :(", "\n\nGenerally it is the nickel that causes your ears to itch. ", "Claire's offers nickel-free sensitive skin earrings that might be the place to start. ", "The nail polish thing helps as well and usually two coats is enough unless you wear the same pair all the time and/or in water. ", "Good luck! ", "I love earrings and hate when I react to a pair.", "\n\nI never take out my earrings because 1) they are diamonds that my husband bought me as a wedding gift (I have 7 piercings-- four diamonds and three hoops) 2) the hoops are never-ending (once you put them in you cannot get them out easily) and 3) the diamonds are screw-backs (you have to screw them in and screw them off). ", "It's not worth trying to switch them! ", "LOL!", "\n\nI wear pearls nearly every single day. ", "I also have two more pairs that I trade off between if my pearls don't really *go* that day.. ;-) They're still studs though, and I got them at Anthro. :-) (", "They don't have the exact color I have, but pretty close... ;-) )\n\nI'm from Seattle. ", "Chris is from Denver. ", "We met at BYU and got married in 2007 in the Nauvoo, IL temple. ", "Chris graduated from the USC School of Dentistry in 2013 through an Army scholarship and now we owe 4 years of dental service. ", "We are stationed in Grafenwöhr, Germany and we LOVE to travel all around Europe! ", "I'm a stay-at-home-working-mom to our son Fox and daughter Jane. ", "Scrapbooking is my passion and I have my own signature collections with Pink Paislee called Fancy Free and Take Me Away! ", "I'm a blogger for Scrapbook Expo, a teacher at Big Picture Classes and Craftsy, and I have an Etsy shop on the side. ", "I also enjoy teaching scrapbooking and bookbinding workshops. ", "We love life and can't wait to see what tomorrow brings." ]

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[ "First of all, the build quality, and the extras provided are second to none. ", "The block is beautifully machined from a specially chosen brass alloy for maximum musicality and sustain.", "\n\nSure, the KGC blocks are a bit more expensive than the competition, but they throw in the extras like 5 upgraded extra long stainless steel mounting screws. ", "The KGC blocks also come with a great brass spring retaining bar with matching brass screws. ", "KGC have made a major improvement with retaining bar by adjusting where the screws to hold the retaining bar attach to the block, allowing you to still use the retaining bar with up to five springs. ", "You certainly can’t do that with the stock setup! ", "Everything about the design of the block is well thought out.", "\n\nInstalling the block was easy enough. ", "I did need to remove all the saddles to access the 5 screws that hold the stock block on. ", "I recorded the distance from the edge of the baseplate for each saddle so I could get the intonation as close as possible when it came time to re-install the saddles. ", "The one set back I had was stripping out one of the saddles intonation screws. ", "No fault of the block, just the soft metal that these screws are typically made of. ", "I raided one from one of my other guitars to finish the installation, and ordered a new one from my local music shop.", "\n\nOnce everything was back in its place I got onto testing. ", "The KGC brass block gave me a bolder, more complex tone. ", "My guitar felt more alive and resonant. ", "The brass claw had given me a boost, and the brass block just took everything to eleven.", "\n\nThe tone was warmer and fuller sounding than with the stock pot metal block. ", "The brass block compressed my tone, which gives an impression of extra volume, and helps with aiding sustain. ", "My guitar sounded more articulate, with better string definition.", "\n\nI didn’t find that the KGC block hindered my use of the whammy bar. ", "Those of you worried about losing some of your pull-up range have nothing to fear. ", "There’s still enough room to do the craziest of dive bombs and harmonic squeals after upgrading to a KGC brass block.", "\n\nOverall the Killer Guitar Components Ibanez Edge Pro Brass Tremolo Block is an excellent upgrade to any Edge Pro equipped Ibanez. ", "Combine it with the brass claw and you are in for a massive tonal treat. ", "Sure the KGC gear is a bit more expensive than the competition, but with the quality and extra features of the KGC gear you really can’t go wrong." ]

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[ "The Director (sometimes referred to as The AI Director, or simply as AID) is the artificial intelligence of Left 4 Dead that features a dynamic system for game dramatics, pacing, and difficulty.", "\n\nInstead of set spawn points for enemies, the Director places enemies in varying positions and numbers based upon each player's current situation, status, skill, and location, creating a new experience for each play-through. ", "The Director also creates mood and tension with emotional cues, such as visual effects, dynamic music, and character communication. ", "Moreover, the Director is responsible for spawning additional health, ammo, weapons, and Special Infected, like the Witch or the Tank.", "\n\nIt should be noted that there is another Director in the game, which controls the music on a per-player scale, called the Music Director. ", "This article will only deal with the main one, the Director in charge of spawning enemies and items.", "\n\nEnemy spawning [ edit | edit source ]\n\nThe Director's most immediately obvious influence is of the spawning and managing of Infected. ", "In general, the Infected are spawned out of sight from the Survivors, and are de-spawned after the Survivors move out of range (although, there are exceptions). ", "The Director categorizes enemies as Wanderers, Mobs, Specials, and Bosses.", "\n\nThe Director divides Commons into two types - Wanderers and Mobs. ", "Wanderers are spawned in front of the Survivors, with the highest concentration being on the main path, but with decent amounts placed in side routes and in unreachable locations (known as background wanderers). ", "These Commons will \"wander\" (as per the name), and will attack upon noticing the Survivors.", "\n\nMobs (Hordes), on the other hand, are usually spawned to the side or behind the Survivors. ", "Mobs consist of 10 - 30 Commons, and generally spawn in intervals of 1-4 minutes (varying with difficulty). ", "In certain instances the Director will be unable to find a suitable spot to spawn a Mob, granting the Survivors momentary reprieve from the Horde. ", "However, the Director will continue to \"queue\" Mob Infected until the Survivors leave this spot, effectively punishing them with a larger Mob. ", "Unlike Wanderers, Mobs will immediately hunt down the Survivors upon spawning.", "\n\nA maximum of 30 Commons can be spawned by the Director at any one time. ", "A higher number of Commons may exist on the map, but the Director will not spawn any more until their number is 0.", "\n\nIn Campaign mode, the Director will kill off any Special Infected that are too far from the Survivors. ", "This can be seen by turning on Full Captions. ", "Specials can spawn inside the ending Safe Room, effectively locking them inside until the Survivors open the door.", "\n\nWitch and Tank spawns are handled very differently by the Director. ", "Throughout each map there are a select number of \"Threat\" locations - spots where the Director will spawn a Tank or a Witch. ", "These Threat spots are normally on the main path, and are always the same - no matter how many times you go through a map, Tanks and Witches can only spawn in these areas. ", "It seems that The Director has a bigger tendency to spawn idle Witches at unavoidable spots in Left 4 Dead 2, while in Left 4 Dead Witches will often spawn on open areas or alternate paths as well. ", "This probably was done to balance with the Wandering Witches on the daylight campaigns, who can be avoided easily.", "\n\nTanks will turn hostile immediately upon making line of sight with a Survivor. ", "This can become problematic for the Tank if the map is particularly maze-like and/or loops back on itself. ", "The Director will also turn the Tank hostile if the Survivors manage to get past it unnoticed or deal damage to it. ", "With the exception of Versus and specific Mutations, Special Infected are prevented from spawning while the Tank is in play (a string for this exists, telling the Infected to wait for the Tank battle to end). ", "However, if a Survivor(s) are run away from the Tank, the Director will remove the string, allowing Special Infected to spawn and attempt to intercept the runners.", "\n\nIn Versus mode, the Director imposes a \"Flow Limit\" upon Bosses, stopping them from spawning too close to one another or to the Safe Zones / Checkpoints. ", "This limit is not used in Co-op and can result in a Tank and Witch spawning together, and/or inside a Safe Room. ", "However, it is impossible for successive repeats to occur, such as two tanks in a row without a break in between.", "\n\nIn Finales, the Director summons Tanks after two hordes have been defeated; additional hordes caused from the boomer's puke may delay the tank spawn. ", "In order for the finale state to advance, the Tank must die; removing the Tank will result in an infinite loop. ", "Once the second Tank is defeated and the rescue vehicle arrives, this string is removed and the Director will send both Tanks and hordes at the team, although it can occasionally glitch out where the Tank or neither Tank and horde arrives. ", "Should the third Tank be killed, the finale loop replays again until the team escapes, but if they intentionally hold out for longer then hordes will spawn with an unending wave of Tanks that have no cooldown between them after the previous Tank(s) die.", "\n\nMany map events will change the rules of Infected spawning, especially Finales. ", "They can change the limit and rate of Special spawning (e.g. the Dead Center Finale), the rate and size of Mob spawns (e.g. the Dark Carnival 4 onslaught) and even force Boss Infected to spawn (e.g. the numerous Tanks in the Sacrifice Finale).", "\n\nItem Spawning [ edit | edit source ]\n\nUpon loading a map, the Director immediately populates it with items by selecting a limited number of pre-placed spawn points. ", "In reality, the Director has very little control over where items will spawn, mostly limiting the number of similar items spawning close to each other. ", "The Director is not to be confused with random chance factors, such as tier two weapon spawn locations being randomly chosen from several spots once the game starts. ", "The Director is still capable of changing items based on the team's performance; for example, if they are low on health, it may spawn health kits nearby at the pre-placed spawn points.", "\n\nThe sole exception is Pain Pills, where the Director will put them in first aid cabinets. ", "The Director will change this to either Medkits (if survivors are on low health, but not in black and white) or Defibrillators if someone is about to die, especially on Advanced or lower difficulty. ", "When the Director converts pain pills into first aid kits, it will always do so in advance of the farthest point the survivors have reached. ", "The cvar \"director_convert_pills_critical_health\" is related to the chance of conversion; the amount of players with first aid kits also dramatically alters the chances. ", "As an example, if a team was roughly half-way through a chapter, all of the pills found up until that point will remain as pills if the survivors become very low on health. ", "Only the pills on the unexplored half of the map are eligible to convert into first aid kits. ", "This is true even if the survivors retreat back to the starting saferoom and take more damage.", "\n\nSeveral items are always static and will always be there, regardless of the team's performance. ", "The Director cannot change the items. ", "Such examples include the Silenced Submachine Gun when Survivors start The Hotel's Crescendo Event and the two Health Kits under the tent in The Park.", "\n\nDynamic Maps [ edit | edit source ]\n\nA feature only implemented in Left 4 Dead 2, dynamic map design allows the Director to measure how well the Survivors are doing, and change the map accordingly. ", "These changes can include small path tweaks, object and item spawns, weather patterns, even re-pathing of entire events. ", "Here are a few examples:\n\nLogic exists in the map files that indicates the elevator was going to have multiple stops, one of which would be chosen by the Director. ", "However, it appears this idea was scrapped.", "\n\nAfter the Crescendo Event, the Director may place an alarm on one of the two red cars at Liberty Mall's parking spot.", "\n\nThe path to the Crescendo Event changes, leading to either a security door or the window of a toy store. ", "In Versus, the path will always default to the toy store to keep the match fair.", "\n\nThe event itself is subject to numerous path changes, depending on the Survivor's skill.", "\n\nAt the beginning of the level, the Director may spawn a fence along the main path.", "\n\nTorrential rain will occur randomly through the map, obscuring vision and muffling the voices of other Survivors, which are often accompanied with mob attacks.", "\n\nAccording to Developer Commentary, the park area was originally going to have dynamic pathing. ", "However, through play-testing it was discovered that players found it more enjoyable to simply have the whole area open to them.", "\n\nMany of the graves in the cemetery are dynamic, forcing the Survivors to take longer routes if they are doing well. ", "Any and all dynamic map changes are kept the same for both teams when playing Versus mode.", "\n\nDirector Phases [ edit | edit source ]\n\nWhile playing through a map, the Director goes through a number of \"phases\", relating to the state of the Survivors. ", "This adds an ebb-and-flow dynamic to the game, allowing the Survivors to recover after a nasty incident, or meet heavy resistance when rapidly progressing through a map. ", "Experienced players will be able to predict the current Director phase, and act accordingly.", "\n\nBuild Up [ edit | edit source ]\n\nUpon leaving the safe zone, the Director enters Build Up mode. ", "In this mode, Commons and Specials will spawn normally, and Mobs will appear regularly.", "\n\nThe Director reaches \"Peak\" when the Survivors are at maximum Intensity (see below). ", "It usually occurs at the peak of combat. ", "Infected normally stop spawning at this point.", "\n\nDuring Relax phase, Survivors may rest and recuperate after passing through Peak phase. ", "No Wanderers, Mobs or Specials will spawn. ", "In Left 4 Dead 2, a feature is introduced where Wanderers may still spawn during Relax mode - the harder the difficulty, the quicker they will start spawning again.", "\n\nRelax normally lasts about 30-45 seconds, but will finish quicker if the Survivors start moving again. ", "After Relax mode has finished, the director returns to Build Up mode.", "\n\nSurvivor Intensity [ edit | edit source ]\n\nThe Director constantly measures how much pressure each individual Survivor is under by monitoring their Intensity. ", "A Survivor's Intensity increases when attacked by an Infected, and by killing Infected that are close by. ", "Survivors will immediately reach maximum Intensity when incapacitated. ", "Survivors will not gain intensity through friendly fire, or when sniping distant Infected.", "\n\nQuieting the Director [ edit | edit source ]\n\nIn certain instances, the Director, for all intents and purposes, is turned off. ", "During this time no Common or Special Infected may spawn, although their timer still counts down, allowing them to instantly spawn when the Director returns to normal.", "\n\nNormally this only occurs in Crescendo Events, Finales and Tank fights. ", "Before the Survivors start the event, so long as they are all in the event area, the Director will wait until the event finishes before returning to regular spawning. ", "The Director also returns to regular spawning if a Survivor leaves the area before starting the event.", "\n\nDifficulty and Game Modes [ edit | edit source ]\n\nInfected get stronger, smarter and more resistant as the difficulty increases. ", "Some of the Director's functions also change with the difficulty. ", "The following functions increase with the difficulty:\n\nThe speed at which Commons appear during Relax mode.", "\n\nThe rate of Mob spawns.", "\n\nVersus Mode [ edit | edit source ]\n\nIn Versus Mode, certain variables are changed to make sure the game is balanced for Infected players, as well as when the teams are swapped over:\n\nTanks and Witches spawn in similar spots for both teams.", "\n\nItem placement is always the same for both teams. (", "e.g. if a Laser Sight upgrade is found at the second to last house in The Milltown by the human team, upon teams being swapped those players will find it at the same house too)\n\nAny dynamic paths are kept the same when teams swap.", "\n\nThreat zones are more frequent in Versus, such as The Hotel and on the highway in Dark Carnival where Tanks and Witches may spawn. ", "In any Campaign mode, Tanks and Witches cannot spawn at all for balancing reasons, and they are eligible to appear from the motel and onwards for the latter.", "\n\nReading the AI Director [ edit | edit source ]\n\nWith a bit of practice, it is possible to anticipate moves by the Director;\n\nListen out for music cues. ", "The AI Director works in conjunction with the Music Director. ", "Each campaign has unique tones for Build Up and Relax modes, as well as Incoming Attacks / Mob spawns.", "\n\nAfter a particularly nasty attack, you can expect the Director to take it easy for a while. ", "Use this to your advantage to heal up.", "\n\nThe Director sometimes de-spawns idle Infected to make room for incoming mobs; the same also appears when a Witch or Tank is nearby. ", "Be on guard if you do not see a lot of idle Infected. ", "However, this acts as a double-edged sword for the Director as well; since mobs spawn in the closest spot when it spawned the horde, their spawn points will be around the area the lead player was at the time. ", "Passing through that area quickly results in less Infected to deal with along the main path due to the capacity the Director can hold, but they may counter it by spawning Special Infected along the path.", "\n\nIf two or more players have low health, expect the Director to be more generous on healing items. ", "This can be manipulated into the Director spawning many health kits (e.g. the Bridge's saferoom, where the Director can spawn anywhere from 4-10 Health Kits inside).", "\n\nConsole Commands [ edit | edit source ]\n\nA number of console commands exist that allow the observation and editing of the Director's functions. ", "Most of these are protected by sv_cheats and thus cannot be used in regular play. ", "Note - the developer console can only be used with the PC version of the game.", "\n\nDebug commands [ edit | edit source ]\n\ndirector_debug - Set to 1 for a monitor of the Director's current thought process.", "\n\ndirector_debug_scavenge_items - Indicates the location of all possible item spawns, and which ones the Director has chosen for this particular run.", "\n\nz_debug - Shows the location and status of all Infected, as well as a preview of the Navigation Mesh, which indicates Threat zones and places where Wanderers and Mobs cannot spawn.", "\n\nz_show_flow_delta - Set to 1 or 2 for an indicator of the general \"flow\" of the map, which the Director uses to determine where to spawn Infected.", "\n\nCheat commands [ edit | edit source ]\n\nz_common_limit - Change the maximum number of Common allowed in a map at any one time.", "\n\ndirector_special_respawn_interval - The time it takes for Specials to re-spawn.", "\n\ndirector_tank_bypass_max_flow_travel - The Director will alert the Tank if the Survivors get this far past him." ]

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[ "\"Toodle-fucking-oo\" \"Hey, no speeding.\" \"", "This is a party zone!\" \"", "Come on!\" \"", "We can do it!\" \"", "Hey, Janet Jackson.\" \"", "Hi, Mr. Soprano!\" \"", "Where's Meadow?\" \"", "I give up. ", "ln the house?\" \"", "Tony.\" \"", "Billy, thanks for calling.\" \"", "As soon as I found out it was your mom's place.\" \"", "O.D. Friend says Special K and ecstasy.\" \"", "You fucking kidding me?\" \"", "Your kid's all right.\" \"", "She's a little drunk.\" \"", "32 1, repeat, you're breaking up.\" \"", "529, are you in pursuit of vehicle on 75 North?\" \"", "ln your grandmother's house.\" \"", "lt wasn't my fault.\" \"", "If I had a quarter every time I heard that...\" \"... I'dhaveaprivatejet on 24-hour standby.\" \"", "Get in the car.\" \"", "ln your grandmother's house.\" \"", "Now he's repeating himself.\" \"", "Just lucky l knew that cop.\" \"", "So he cut me a favor.\" \"", "Let me guess, he owes you money?\" \"", "What did she do?\" \"", "Go upstairs.\" \"", "No, I want to see the fight.\" \"", "Get your little ass up those stairs!\" \"", "Meadow!\" \"", "We can talk about it in the morning.\" \"", "Get down here!\" \"", "Let her go to bed.\" \"", "I want her to answer for herself!\" \"", "She's drunk!\" \"", "Was she driving?\" \"", "I could've taken ecstasy but I didn't!\" \"", "Don't puke on the floor!\" \"", "You still up?\" \"", "Go to bed!\" \"", "She's on ecstasy and you yell at me?\" \"", "Get up there!\" \"", "What did she say for herself?\" \"", "The usual shit. \"", "Wasn't my fault. \"\" \"", "There was designer drugs there, Tony.\" \"", "So, what did you say?\" \"", "I don't know. ", "I yelled.\" \"", "What the fuck else am I gonna do?\" \"", "You sure you're gonna be all right, Uncle Rich?\" \"", "I want to walk.\" \"", "See if I run into any of the old crowd.\" \"", "Thanks, doll.\" \"", "Motherfucker.\" \"", "There has to be consequences.\" \"", "What kind of parents would we be if we let her get away with this?\" \"", "Typical?\" \"", "Plenty of parents still crack the whip.\" \"", "Yeah, that's what they tell you.\" \"", "I cannot wait until she goes off to college.\" \"", "Oh, right, so you can get Empty Nest Syndrome...\" \"... andgoon Wellbutrin like your sister.\" \"", "As a parent today, you are over a barrel no matter what you do.\" \"", "You take the car, you're a chauffeur.\" \"", "Ground her, you stay in and be a prison guard.\" \"", "Throw her out, social services returns her...\" \"... andwefaceajudge.\" \"", "She's not 1 8 yet.\" \"", "That's your solution?\" \"", "All I'm saying, with the laws today, you can't restrain your kid physically.\" \"", "She could sue you for child abuse.\" \"", "There has to be consequences.\" \"", "And there will be.\" \"", "I hear you, okay?\" \"", "Let's not overplay our hand. ", "lf she knows we're powerless, we're fucked.\" \"", "Hey.\" \"", "That guy wants to talk to you.\" \"", "Jesus.\" \"", "Mother of Christ!\" \"", "Richie.\" \"", "So when did you get out?\" \"", "How come nobody told me?\" \"", "That's funny.\" \"", "Paulie Walnuts told me he ran into you this morning.\" \"", "Honest to fucking God, nobody said a word.\" \"", "Just shut the fuck up.\" \"", "You know, I did a lot of meditation in the can on this.\" \"", "On what?\" \"", "You can't believe how crazy things... .\" \"", "You ever meditate?\" \"", "Me?\" \"", "Meditate?\" \"", "Are you crazy?\" \"", "Not as crazy as I used to be.\" \"", "But still crazy enough to take an eye out.\" \"", "What's going on here, Rich?\" \"", "Ten years.\" \"", "And not even a pleasant \"Go fuck yourself\" from you I get.\" \"", "You know, I always asked how you were doing.\" \"", "Hold on there.\" \"", "You.\" \"", "How could you let my dear friend sit here with an empty cup?\" \"", "l'm sorry.\" \"", "That's all right.\" \"", "Take it easy, kid.\" \"", "Bring this gentleman a veal-parm sandwich.\" \"", "And hurry the fuck up about it.\" \"", "The other two stores doing as good as this?\" \"", "Come on, you know, it's a grind.\" \"", "That doesn't answer my question.\" \"", "Rich, I know you're a made guy, so I lose either way.\" \"", "But I always respected you and your brother, Jackie.\" \"", "I'm no victim here.\" \"", "I'm not some greaseball storeowner.\" \"", "I'm sorry, Richie.\" \"", "I will not be shaken down.\" \"", "This sucking up to Tony Soprano has done wonders for you.\" \"", "I go away for a while. ", "I come back, you're a tough guy.\" \"", "Don't do this.\" \"", "Do what?\" \"", "Take what's owed to me?\" \"", "What's owed to you?\" \"", "l put you in action, Beansie.\" \"", "You got a bad memory, Beansie.\" \"", "Veal parmigiana sandwich.\" \"", "Fuck you.\" \"", "I'll be back every Saturday, partner.\" \"", "I don't fucking believe this.\" \"", "I'm being shaken down, for what?\" \"", "Tell me, what did I do?\" \"", "This is not right.\" \"", "I'm not gonna fucking lay down.\" \"", "I'll step up.\" \"", "Won't lay down, huh?\" \"", "You don't want to lay dawn?\" \"", "You piece of shit!\" \"", "All right, let's get her down here.\" \"", "I guess.\" \"", "Where is the Bride of Frankenstein?\" \"", "She's still sleeping.\" \"", "Yeah, right.\" \"", "Go wake her up.\" \"", "l wake her up?\" \"", "I want to get this shit out of the way before I go out.\" \"", "You guys are making too much of this.\" \"", "l don't think we're making enough.\" \"", "She was drunk.\" \"", "Her choice.\" \"", "There's a Zuni saying:\" \"\"For every 20 wrongs a child does, ignore 1 9. \"\" \"", "There's an old Italian saying:\" \"\"You fuck up once, you lose two teeth. \"\" \"", "That's what all this is about.\" \"", "Ego and control.\" \"", "l beg your pardon?\" \"", "No, don't try to make sense with her.\" \"", "No, I want to understand this.\" \"", "Go ahead, tell me.\" \"", "You want to hold on to control over a young woman...\" \"... whoseentire biological determinism...\" \"... istoachieveindependent thought and behavior.\" \"", "She's exercised her independence...\" \"... butyouwanttopenalizeher because you don't like her choices.\" \"", "Go get a fucking permanent.\" \"", "I'm trying to watch TV!\" \"", "Well.\" \"", "Good morning.\" \"", "I'm sorry, is it afternoon?\" \"", "Mom, please.\" \"", "Please what?\" \"", "You'd better have some answers.\" \"", "Yeah.\" \"", "That's right!\" \"", "Fine.\" \"", "You're punished.\" \"", "For what?\" \"", "I didn't do anything!\" \"", "You did nothing?\" \"", "lt wasn't my fault!\" \"", "lt's never your fault, Meadow.\" \"", "It was gonna be me, Hunter and the Macaluso twins.\" \"", "Then Steve shows up with Adam and people from Boonton!\" \"", "So Steve's just trying doorknobs till he hits the jackpot?\" \"", "No, Hunter tells him.\" \"", "Now with the Hunter.\" \"", "And she's at home, blaming it on you.\" \"", "It's an old game.\" \"", "You try studying day and night to get into college.\" \"", "We work hard.\" \"", "We deserved a night!\" \"", "Take it easy.\" \"", "Take it easy.\" \"", "I'm sorry you're under a lot of pressure. ", "lt's still no excuse.\" \"", "So who was this ecstasy guy?\" \"", "l just told you.\" \"", "Adam.\" \"", "I don't know him.\" \"", "He came with Steve.\" \"", "The Steve I know?\" \"", "The school kid you're always with?\" \"", "He's a flake.\" \"", "Why do you think I stopped hanging with him?\" \"", "That's news to me you don't hang out with Steve.\" \"", "It's painful to talk about, okay?\" \"", "You're gonna get punished.\" \"", "Look, you guys, I know what I did was not okay.\" \"", "I've been thinking about it a lot and really not feeling good about myself.\" \"", "You should take away my Discover card.\" \"", "You better believe it!\" \"", "That's right!\" \"", "For two weeks.\" \"", "Three!\" \"", "How do I buy gas?\" \"", "Your allowance.\" \"", "I spent my allowance.\" \"", "And I already owe Mom.\" \"", "The Pashmina.\" \"", "We can wait on that.\" \"", "You get 1 0 dollars a week.\" \"", "Cash.\" \"", "No more.\" \"", "Till you get your card back.\" \"", "For gas!\" \"", "Come here.\" \"", "Look at you.\" \"", "You look great.\" \"", "You're sinew.\" \"", "You sack of shit. ", "lf you lost that baby fat, you'd disappoint me.\" \"", "Hey, fuck you.\" \"", "You been laid yet?\" \"", "God, what's wrong?\" \"", "I'm trying.\" \"", "Hey, I said 4:00.\" \"", "I leave before the stock market closes...\" \"... youyellfornot watching the phone guys.\" \"", "Meet Richie Aprile.\" \"", "Jesus Christ, how you doing?\" \"", "Your brother, Jackie, was like a fucking god.\" \"", "A great leader.\" \"", "And I heard a lot about you.\" \"", "Yeah, well, I heard a lot about you.\" \"", "That's why I'm here.\" \"", "What do you mean?\" \"", "Out of respect for our friend here, I'm gonna talk nice.\" \"", "I ever hear you raise your hands to my niece again...\" \"... nexttimeyouwon 'tsee myface .\" \"", "You understand?\" \"", "Who told you I put my hand on her?\" \"", "is this kid getting jerky with me?\" \"", "Look, kid, I shouldn't have to explain myself.\" \"", "I'm from the old school.\" \"", "You want to raise your hands, give her your last name.\" \"", "Then it's not my business.\" \"", "Until then, keep your hands in your pockets.\" \"", "We understand each other?\" \"", "Now get out of here.\" \"", "I want to talk to Tony.\" \"", "Go ahead.\" \"", "He's a good kid.\" \"", "Capable.\" \"", "Look, Ton, this is the thing.\" \"", "I want to get my shy business back.\" \"", "I keep getting calls from Jackie's customers\" \"Where the fuck are you going?\" \"", "l'll talk to you later, Richie.\" \"", "What just happened?\" \"", "No more business talk with him directly.\" \"", "You fucking with me?\" \"", "You can talk to him.\" \"", "But not now.\" \"", "And never here.\" \"", "Can you believe we drank a whole bottle of wine?\" \"", "Thank God!\" \"", "Cheers.\" \"", "Cheers.\" \"", "We're out of here.\" \"", "Okay.\" \"", "Richie broke a chair over his head.\" \"", "You shitting me?\" \"", "Hit him with a coffeepot too.\" \"", "Broke his cheekbone.\" \"", "Prick. ", "I talked to him yesterday.\" \"", "He's all sweetness and lights.\" \"", "Already this shit's getting old.\" \"", "Yo, bright eyes.\" \"", "Where you going?\" \"", "This isn't the Bing, huh?\" \"", "Fuck did I say?\" \"", "Hey, how have you been?\" \"", "Can't complain.\" \"", "You look good.\" \"", "Where did your friends go?\" \"", "Tell them to come back, join us.\" \"", "No, they're leaving.\" \"", "First time here.\" \"", "Excellent veal.\" \"", "We making small talk now?\" \"", "Nice to see you.\" \"", "Yeah, you too.\" \"", "Toodle-oo.\" \"", "Bye-bye.\" \"", "Not a bad ass.\" \"", "She had nice pipe-fitter lips.\" \"", "No disrespect.\" \"", "Hey, what do I give a fuck?\" \"", "I hardly know her.\" \"", "You mean, you would take the lips over the tits?\" \"", "Trust me, my boy.\" \"", "There's two things I'm good at:\" \"It's pulling dents and spotting good blowjobs.\" \"", "And that sweetie had world-class blowjob lips.\" \"", "Am I right, skipper?\" \"", "Good or no?\" \"", "What the fuck do I know?\" \"", "It was a long time ago.\" \"", "All right, she was good.\" \"", "All right?\" \"", "Good?\" \"", "Or great?\" \"", "Why you busting my balls?\" \"", "It was a long time ago.\" \"", "Hey, I remember every blowjob i ever got.\" \"", "You remember your first blowjob?\" \"", "Yeah, of course.\" \"", "How long did it take for the guy to come?\" \"", "I said, \"You remember your first blowjob?\"\" \"\"", "Yeah. \" \"", "How long did it take for the guy to come?\"\" \"\"", "Toodle-fucking-oo\"?\" \"", "What the fuck was that?\" \"", "I couldn't sleep from the embarrassment.\" \"", "What was so wrong?\" \"", "It's an accepted form of goodbye.\" \"", "That's not the way I talk with patients.\" \"", "It wasn't me. ", "lt was someone else.\" \"", "It was Jennifer.\" \"", "For whatever reason, at that moment, you felt safer showing him Jennifer.\" \"", "What did you see at that table that made you want to hide \"Doctor\"?\" \"", "Who were you hiding from?\" \"", "I saw a patient that I never wanted to see again.\" \"", "That's who I was hiding from.\" \"", "A patient.\" \"", "When you say \"see\" ...\" \"... doyoumeanprofessionally or just plain \"see\"?\" \"", "What's the difference?\" \"", "There's a big difference.\" \"", "If it was just a matter of just plain old \"see\" ...\" \"... thecordialdoctor would've said, \"Good night. \"\" \"", "But, because he's someone you didn't want to see professionally...\" \"... youabandonedthedoctorfaçade and adopted the Jennifer posture.\" \"", "Hence, \"Toodle-oo. \"\" \"", "You're almost there, Elliot, but not quite.\" \"", "Young girls are not accountable for their behavior.\" \"", "I think \"Toodle-oo\" was the action of a ditsy young girl.\" \"", "And I regressed into the girl thing to escape responsibility...\" \"... forabandoningapatient.\" \"", "He asked me for help.\" \"", "Look, I need you as a colleague to tell me that I did the right thing.\" \"", "You gotta ask yourself why you became a psychiatrist.\" \"", "If it was to help people stop smoking or biting nails...\" \"... thensobe it .\" \"", "There's nothing wrong with that.\" \"", "Another patient committed suicide because I was treating this man.\" \"", "Because I had to go on the lam.\" \"", "Treating patients from a motel room isn't optimum...\" \"... butyouwerethereforher, in phone contact.\" \"", "It would have been the same if you'd been on vacation.\" \"", "Did you say \"lam\"?\" \"", "And lifting up into Cobra.\" \"", "And now rising up into Downward Facing Dog.\" \"", "Coming back down into Cobra.\" \"", "And relaxing into Child's Pose.\" \"", "Richie.\" \"", "Janice.\" \"", "You know, I thought that was you.\" \"\"", "Parvati. \"\" \"", "I changed my name to Parvati in '78.\" \"", "I thought you lived in California now.\" \"", "Seattle, actually, last couple years.\" \"", "So, how long you been... ?\" \"", "Out of jail?\" \"", "One week.\" \"", "That's where l picked up this yoga shit.\" \"", "It's working.\" \"", "You seem very supple.\" \"", "I'm doing a lot of stretching.\" \"", "So you back now?\" \"", "My mom's at St. Erasmus.\" \"", "A stroke.\" \"", "Sorry to hear that.\" \"", "Tony didn't say anything about it.\" \"", "Guess we're all getting a little old.\" \"", "Only if that's our choice.\" \"", "Drag me all the way out here-- l walk through the food court, this kid spills fried rice on me.\" \"", "Take it easy.\" \"", "Keep your voice down.\" \"", "Let's talk.\" \"", "Yeah, let's.\" \"", "How would you feel?\" \"", "Your crew evaporates, then you walk away from me like I got a disease.\" \"", "I don't talk business.\" \"", "Don't take it personal.\" \"", "I'm a government target.\" \"", "Why do you think we're meeting in a fucking mall?\" \"", "It feels disrespectful.\" \"", "You know, that's all I'm saying.\" \"", "I'm the guy who saved you from the hit parade.\" \"", "When?\" \"", "When did you ever step in for me?\" \"", "You forget?\" \"", "You and my brother stuck up Feech LaManna's card game?\" \"", "Feech was a made man.\" \"", "If it wasn't for me, you would've got a vicious beating, to say the least.\" \"", "You know I love you.\" \"", "You're like my big brother.\" \"", "You'll be taken care of.\" \"", "What was yours before you left will be yours again.\" \"", "You just gotta give us some time.\" \"", "Jeez, Anthony, you'd do that for me?\" \"", "Hey, fuck you.\" \"", "What's mine is not yours to give me.\" \"", "Hey, prick, you reached out to me.\" \"", "l said what I wanted to say.\" \"", "Well, we got a problem, kid?\" \"", "I'm trying to get you to slow down.\" \"", "Things are different now.\" \"", "You gotta be extra, extra careful.\" \"", "When do you know me not to be careful?\" \"", "When?\" \"", "You been out of the can 1 0 minutes, you shake down Beansie for a piece.\" \"", "Do me a favor, back off.\" \"", "He's a good earner.\" \"", "Yeah, for you.\" \"", "That's none of your fucking cazzi.\" \"", "Those joints are a cash business.\" \"", "They come in handy.\" \"", "He's a sneaky cocksucker.\" \"", "Whatever, back off.\" \"", "You taking the side of a civilian over me?\" \"", "Christ, I'm asking you to do me a favor.\" \"", "Do it if you want to.\" \"", "If you don't, go fuck yourself.\" \"", "Oh, yeah?\" \"", "Yeah.\" \"", "How's your sister?\" \"", "There's no need for that talk.\" \"", "What?\" \"", "My sister.\" \"", "Janice.\" \"", "How's she doing?\" \"", "Oh, I thought you were baiting me.\" \"", "You know... .\" \"\"", "How's your sister?\" \"", "Fuck your mother. \"\" \"", "See what she did?\" \"", "Who?\" \"", "Meadow.\" \"", "That house is fucked!\" \"", "Thought you didn't swear.\" \"", "What are you talking about?\" \"", "I'm outraged.\" \"", "No, I am beyond outraged.\" \"", "Talk about disgrace?\" \"", "Disrespect for other people's property?\" \"", "It's like a freaking shooting gallery.\" \"", "It smells of urine, there's puke all over the hardwood floors\" \"Sounds like your place in Venice.\" \"", "She's been punished.\" \"", "Three weeks without a card.\" \"", "Oh, Madonna, that's some heavy shit there!\" \"", "Janice... .\" \"", "lf that was my child\" \"You got a lot of fucking balls, you know that?\" \"", "Don't talk to me like that.\" \"", "Let's clear the air here.\" \"", "You're a Vishnu-come-lately, playing concerned.\" \"", "Who the fuck are you kidding?\" \"", "You're here to pick the frigging bones.\" \"", "There's a lot I could say right now that I am not gonna say.\" \"", "A lot of balls.\" \"", "Temper tantrums.\" \"", "He hasn't changed one iota since we lived in Newark.\" \"", "Not one!\" \"", "You're passing judgment on him, Janice.\" \"", "On us as parents.\" \"", "How we discipline our children is none of anybody's business.\" \"", "You let that girl walk all over you, you'll regret it.\" \"", "Mother of God, Janice!\" \"", "Are all of you Sopranos the same?\" \"", "I ask you nicely to stay out of it, you pretend not to hear.\" \"", "Maybe you'll hear this.\" \"", "Mind your fucking business.\" \"", "Keep your mouth shut when it comes to my kids!\" \"", "Maybe I've stayed here too long.\" \"", "The fall in the shower didn't affect your pre-existing heart condition.\" \"", "But you already knew that.\" \"", "lt never hurts to be sure.\" \"", "Fucking bum hip.\" \"", "What next does the Man Upstairs have in store for me?\" \"", "You're lucky it was a sprain.\" \"", "The thing is, doc, I've been feeling these, like, little fibrillations.\" \"", "Psychosomatic.\" \"", "You got out of jail on a medical.\" \"", "It's the mind-body connection.\" \"", "Your body's just pitching in to help.\" \"", "Hey!\" \"", "There's my boy!\" \"", "I was afraid you didn't get the message.\" \"", "Put a shirt on, I'm getting a chubby.\" \"", "Doc, this is one of my dearest friends.\" \"", "Richie, this is the best heart man in the world, Doug Schreck.\" \"", "Mr. Soprano oversold me.\" \"", "I'm only the best in the Western world.\" \"", "Fucking ball-breaker.\" \"", "Doc, do me a favor?\" \"", "Me and Richie... .\" \"", "Yeah, no problem.\" \"", "He's good.\" \"", "Lets me use his doctor- patient privilege to meet people here.\" \"", "Fucking house arrest.\" \"", "Federal marshals so far up my ass, I can taste Brylcreem.\" \"", "Jesus, you look good.\" \"", "How you feeling?\" \"", "Better than some, not as bad as others.\" \"", "I gotta meet Tony at a mall, you here.\" \"", "What the fuck is happening?\" \"", "Like the man said, \"May you live in interesting times. \"\" \"", "You met with Tony?\" \"", "It's more like a fucking audience with the pope.\" \"", "What are you gonna do?\" \"", "Whatever you tell me.\" \"", "You and your brother were always good boys.\" \"", "You tell me this is the way it is, then so be it.\" \"", "You tell me otherwise...\" \"... I'myours,Junior.\" \"", "Whatever, whoever.\" \"", "You just say it.\" \"", "Once again, a big welcome home to our guest of honor.\" \"", "Richie was surprised by the changes in 1 0 years.\" \"", "New Jersey has a hockey team.\" \"", "It's interesting, Meadowlands is the only NHL arena...\" \"... wherethepenaltybox is maximum-security.\" \"", "Maximum-security penalty box.\" \"", "Help me.\" \"", "What the fuck?\" \"", "I was talking to Paulie Walnuts...\" \"... whothoughtthatRichie had been in Bosnia...\" \"... wherethere'salso a large Muslim population.\" \"", "That's it.\" \"", "Out of here.\" \"", "Enough.\" \"", "And now for all you youngsters with visions of tit-fucking in your head...\" \"... herearetheBinggirls!\" \"", "Come on!\" \"", "Hey.\" \"", "Welcome home.\" \"", "Wait till you open it. ", "lt's all ones.\" \"", "I'm a grandfather now, Rich.\" \"", "Imagine that?\" \"", "Please, no pictures.\" \"", "Exploiting medical curiosities is against the law.\" \"", "That why they canceled your mom's audition?\" \"", "What did you say?\" \"", "lt's a homecoming.\" \"", "Cocksucker.\" \"", "Take a walk.\" \"", "Welcome home, Rich.\" \"", "ls Beansie here?\" \"", "Haven't seen him.\" \"", "Richie, how's your balls?\" \"", "They're hanging.\" \"", "Ready and waiting.\" \"", "What?\" \"", "Go with Silvio.\" \"", "Who?\" \"", "Go!\" \"", "I'll hold this.\" \"", "Don't worry about it.\" \"", "Come on.\" \"", "This guy.\" \"", "Trust me!\" \"", "He's got a real fucking attitude problem.\" \"", "Careful.\" \"", "Come on.\" \"", "He just did 1 0 fucking years.\" \"", "He has a right to be a bit fucked up.\" \"", "Richie will be all right.\" \"", "I see you like the dark.\" \"", "Yeah, something like that.\" \"", "Silvio says we can't take it.\" \"", "Whose joint did you just cop, mine or his?\" \"", "Did we do something wrong?\" \"", "You were fine.\" \"", "Get out of here.\" \"", "Hey, buddy!\" \"", "What the fuck are you doing?\" \"", "What'd you think Tony Soprano was gonna do for you?\" \"", "You got a raging hard-on for me.\" \"", "l don't know what for!\" \"", "You don't?\" \"", "Come here!\" \"", "No.\" \"", "Come here!\" \"", "Come here!\" \"", "How come you weren't at the party?\" \"", "I moved a lot of H for you...\" \"... andyoumadethe lion'sshare.\" \"", "You're just bitter because I invested my money smart and you didn't.\" \"", "I spent mine on lawyers, you slippery fuck!\" \"", "You want to talk like a tough guy?\" \"", "Tough guy, here!\" \"", "Hey, come on.\" \"", "Please, no guns.\" \"", "What happened to \"l'm no greaseball storeowner\"?\" \"", "Tell me again how you won't lay down, huh?\" \"", "Asshole!\" \"", "Janice?\" \"", "l'm sorry, is the music too loud?\" \"", "Oh, no, it's fine.\" \"", "I just wanted to apologize.\" \"", "You know, about earlier.\" \"", "No, I should be apologizing to you.\" \"", "I was out of line.\" \"", "You're right.\" \"", "I never raised a child.\" \"", "I was robbed of that when Eugene took him back to Montreal.\" \"", "I'm petitioning the State Department...\" \"... buttheyhavemeontheir enemy radicals list, so... .\" \"", "When was the last time you saw Harpo?\" \"", "He changed his name to Hal.\" \"", "I'm sorry, Carm, can we not talk about him?\" \"", "Look, I just want you to know that I was way out of line.\" \"", "Well, I'm sorry too.\" \"", "Really, I just feel terrible.\" \"", "You know, you're family.\" \"", "And family means a lot.\" \"", "I just don't feel right about you leaving here.\" \"", "I don't know.\" \"", "I don't think Tony wants me here.\" \"", "Where will you go?\" \"", "The house is in no condition to move into, especially now.\" \"", "I'll be all right.\" \"", "No, I'm sorry.\" \"", "I really can't let you leave.\" \"", "Really, I want you to stay.\" \"", "Okay.\" \"", "Okay.\" \"", "All right.\" \"", "Well, good night.\" \"", "Good night.\" \"", "Oh, maybe just a little bit.\" \"", "The music.\" \"", "Oh, all right.\" \"", "Richie, no!\" \"", "Richie, no!\" \"", "Jesus!\" \"", "Do I put the chocolate in now?\" \"", "Put it in, I'll pour the milk.\" \"", "What did your parents say about Saturday?\" \"", "The usual.\" \"", "Nothing.\" \"", "They're afraid I'll go bulimic again.\" \"", "Mine just \"blah, blah, blah. \"\" \"", "Purge and they won't say anything.\" \"", "When will they realize we're adults, responsible for ourselves?\" \"", "So we had a party at your grandmother's.\" \"", "Would they prefer we go to Limelight?\" \"", "Hello!\" \"", "It's because they have no life.\" \"", "They focus on bullshit.\" \"", "So, what did yours do?\" \"", "They took my Discover card for three weeks.\" \"", "That's nothing.\" \"", "l know, it was my idea.\" \"", "Dicks.\" \"", "So hypocritical too.\" \"", "When you think how my dad makes a living.\" \"", "Oh, jeez!\" \"", "What is this?\" \"", "Why don't you ring for the nurse?\" \"", "Never you mind!\" \"", "That's their job.\" \"", "I don't need them.\" \"", "My daughter came all the way from Seattle.\" \"", "Oh, Jesus!\" \"", "Hello?\" \"", "She rang for you.\" \"", "l did not.\" \"", "Mrs. Soprano.\" \"", "Who are you?\" \"", "Richie.\" \"", "Richie Aprile.\" \"", "But I thought you were dead.\" \"", "No, hon, that was my brother, Jackie.\" \"", "Oh, I'm sorry.\" \"", "How did he die, the poor baby?\" \"", "He had cancer.\" \"", "Me too.\" \"", "Shut that curtain, will ya?\" \"", "You know, I was in a private room.\" \"", "My Johnny would roll over in his grave if he saw this.\" \"", "Oh, they wheel people in and out, in and out.\" \"", "Oh, go on!\" \"", "So isn't Parvati supposed to be here?\" \"", "I don't know who that is.\" \"", "Your daughter, Parvati.\" \"", "Janice.\" \"", "Oh, yeah, please.\" \"", "Don't start with that name business.\" \"", "She did it to shame me.\" \"", "You'll have to have your tea without lemon.\" \"", "Richie.\" \"", "You see the beautiful flowers he brought me?\" \"", "Yeah, see?\" \"", "Your father has friends with class.\" \"", "Not like some people.\" \"", "Ma, he's not one of Dad's friends.\" \"", "He's my friend.\" \"", "You mean, he's your boyfriend?\" \"", "Remember?\" \"", "You used to yell at me...\" \"... forbeepingmy horn when I came to pick up Janice.\" \"", "Pimps beep!\" \"", "You know, someday somebody's gonna wash out your mouth with soap, hon.\" \"", "Oh, yeah, who?\" \"", "You?\" \"", "Oh, I wish the Lord would take me.\" \"", "The man's come to visit you.\" \"", "Take it easy!\" \"", "is that how you talk to your mother?\" \"", "You lay the same trip on everybody who comes.\" \"", "Don't you have any shame?\" \"", "Shame?\" \"", "Oh, I got plenty of shame.\" \"", "Believe me.\" \"", "You don't want to hear what I'm ashamed of.\" \"", "Go ahead, Ma.\" \"", "Shoot your best shot.\" \"", "Never you mind.\" \"", "Just remember what we talked about last week.\" \"", "Ma, I'm gonna go to the cafeteria for some coffee.\" \"", "Are you coming back?\" \"", "Yes.\" \"", "I bet you're very good to your mother.\" \"", "She'll be better when I get her home.\" \"", "Does that mean you're sticking around?\" \"", "lf l don't, who'll take care of her?\" \"", "What about Tony?\" \"", "Long story.\" \"", "You haven't heard what happened?\" \"", "Tony blames everyone else...\" \"... foranythingbadinlife , including Ma.\" \"", "Tony?\" \"", "No.\" \"", "Trust me.\" \"", "Nothing's ever his fault.\" \"", "So, what's with the flowers, Mr. Candy Stripe?\" \"", "I couldn't visit her empty-handed.\" \"", "Oh.\" \"", "You weren't at yoga.\" \"", "l'm very busy with my mother.\" \"", "Too busy for dinner?\" \"", "We weren't good together 20 years ago.\" \"", "Why do you think it's any different now?\" \"", "Let's get to the point.\" \"", "After getting to where l am, it'd be ridiculous to decompensate now.\" \"", "I am so not that person anymore.\" \"", "It works both ways.\" \"", "You know, I don't think I'd be interested in the same Jan I knew.\" \"", "So, what, you've grown?\" \"", "Well, you tell me.\" \"", "Did you ever think you'd see Richie Aprile doing...\" \"... DownwardFacingDog?\" \"", "Can she put more gook shit in here?\" \"", "lt's not that much.\" \"", "Soy milk, tofu, I hate all that shit!\" \"", "Yeah, me too.\" \"", "Shut up, you said you liked soy milk.\" \"", "I lied.\" \"", "She was taking me to the video store.\" \"", "I'm happy Aunt Parvati's staying.\" \"", "The one who thinks you're spoiled?\" \"", "It wasn't my fault.\" \"", "How many fucking times I gotta say it?\" \"", "Hey!\" \"", "Whoa!\" \"", "Don't look like you're gonna cry.\" \"", "You made your bed.\" \"", "I need $1 5.\" \"", "Excuse me?\" \"", "A Cole Porter CD. ", "lt's for Madrigals.\" \"", "We're doing three of his songs.\" \"", "You took my card, remember?\" \"", "Here.\" \"", "What's your problem?\" \"", "Nothing.\" \"", "Thank you, by the way!\" \"", "Janice should be home by now.\" \"", "My sister was almost out and you fall for her con?\" \"", "She can't afford a motel.\" \"", "How about she goes back to where she was for 20 years...\" \"... whileI tookcareofourmother?\" \"", "I thought we couldn't mention Grandma in this house.\" \"", "Fine. ", "I'm not gonna argue with you, Tony.\" \"", "You tell her to leave.\" \"", "I won't. ", "lt's not Christian.\" \"", "See?\" \"", "This shit works out.\" \"", "She's a Buddhist.\" \"", "Hello!\" \"", "We're in here, Par.\" \"", "lsn't it cruel to cut flowers?\" \"", "Richie gave them to Ma.\" \"", "They're beautiful.\" \"", "Aren't they?\" \"", "Richie?\" \"", "Richie Aprile?\" \"", "He went to visit her.\" \"", "You know he always loved Ma.\" \"", "All right, I gotta go.\" \"", "You better water them.\" \"", "I think I hear them crying.\" \"", "Aw, Jesus Christ!\" \"", "Peter, you're scaring your mother.\" \"", "Leave me the fuck alone.\" \"", "Hey, is that a way to talk?\" \"", "Tony?\" \"", "Can you pick up the BBC on that thing, or what?\" \"", "No jokes please, Tony.\" \"", "Only family.\" \"", "Let him stay.\" \"", "How you doing, pal?\" \"", "You said he wasn't gonna bother me, Tony.\" \"", "Jesus.\" \"", "They said I might not walk.\" \"", "Come on, Mom.\" \"", "Let's go downstairs for a little while.\" \"", "You gonna let that animal get away with this?\" \"", "I'll let you talk to your \"friend. \"\" \"", "Don't listen to these fucking doctors.\" \"", "When it comes to spinal injuries, it's all a mystery to them.\" \"", "Paulie's cousin got run over by a forklift.\" \"", "Broke his back.\" \"", "The guy's dancing in tango competitions.\" \"", "All right, here.\" \"", "Here.\" \"", "I can't do it.\" \"", "Come on.\" \"", "Thanks.\" \"", "Thanks, Tony.\" \"", "I might not be able to wipe my own ass, you know that?\" \"", "Your nose is as far as I'm willing to go.\" \"", "Listen...\" \"... Beans.\" \"", "You 1 000%%% sure it was Richie Aprile driving?\" \"", "A thousand percent?\" \"", "No.\" \"", "A fucking million percent.\" \"", "And let me tell you something.\" \"", "He's lucky l ain't no rat fuck.\" \"", "Because the law knows that was no random hit-and-run.\" \"", "Don't start talking foolish.\" \"", "We're old school, right?\" \"", "We wash our own dirty laundry.\" \"", "Hey, am I right, Beans?\" \"", "Yeah, yeah.\" \"", "Old school.\" \"", "Okay, good.\" \"", "So you here to see your ma?\" \"", "I hear she's upstairs.\" \"", "No, I came here to see you, you prick.\" \"", "That's okay.\" \"", "Go do what you gotta do.\" \"", "l told you to back off Beansie.\" \"", "l did.\" \"", "Then I put it in drive.\" \"", "This is funny?\" \"", "He might never walk again.\" \"", "Did you know that?\" \"", "And for what?\" \"", "He didn't duke you enough?\" \"", "He didn't visit you in the can?\" \"", "When did you visit anybody in the can?\" \"", "When's the last time you gave a fuck about anybody but yourself?\" \"", "You remember one thing, and listen good.\" \"", "You want to talk this old school shit?\" \"", "Here's a rule you might remember:\" \"I'm the motherfucking fucking one who calls the shots.\" \"", "You pay me the respect I gave your brother or we're gonna have a problem.\" \"", "A bad one.\" \"", "Now get the fuck out of here.\" \"", "All right, Tony.\" \"", "Yeah.\" \"", "All right.\" \"", "Hey.\" \"", "How you doing?\" \"", "I'll open it, you change the locks.\" \"", "Okay.\" \"", "English Subtitles by Gelula/sdl\"" ]

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[ "An example of a food product that yields high levels of acid for the body to dispose of is a cola drink. ", "Phosphoric acid is one of the ingredients listed on the cola container. ", "The pH of cola is ~3.0, ranging from 2.8 to 3.2. ", "The human kidney can excrete urine with a pH no lower than 5. ", "If one ingests and fully absorbs a beverage with a pH of 3, one has to dilute it 100-fold to achieve a urinary pH of 5. ", "Thus, a can containing 330 mL of cola would result in 33 L of urine! ", "This does not happen because the body buffers the acid of the soft drink. ", "For full buffering, 1 L of cola requires some four tablets of Tums, which contain 16 mEq of carbonate as the calcium salt.", "\n\nA relevant comparison of the metabolic effects of acid phosphate and neutral phosphate was published by Lau et al. (", "1979). ", "Young healthy adults consumed identical diets plus 2 g of phosphate, either acidic or neutral. ", "The total phosphate ingested was identical, but the acid phosphate group ingested an excess of 24 mEq H+. ", "Net urinary acid and calcium excretion were measured. ", "Urinary calcium excretion per day was 52 mg greater in subjects consuming acid phosphate than in those ingesting neutral phosphate. ", "Clearly, it is not how much phosphate is consumed that affects urinary calcium, but whether it is in a chemically neutral or acid form.", "\n\nSo, uh, I guess the phosphoric acid could have a leaching effect on bone calcium if you're not getting enough calcium and/or veggies in your diet. ", "I don't really like that paper as a whole, but I'm too lazy to look up the papers it's citing.", "\n\nThe \"rumor\" was that Aspartame was rushed out to replace Saccharine and Aspartame was found to synthesize into Formadehyde and deposit in the brain causing brain lesions.", "\n\nDon't know how much of this is true.", "\n\nI've heard a few times that this happens when it warms to body temperature, which is why you should never leave a pallet of diet soda out in the sun. ", "Never took the time to see if it was true, though. ", "Bottom line is that, even without the sugar, the other ingredients in sodas are just bad for you in general. ", "Colas in particular have been linked to kidney stones.", "\n\nI actually gave up soda years ago. ", "You'd be surprised how little I miss it." ]

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[ "Q:\n\nSwiftUI: How should ForEach views be formulated to make Strings from an array into Text() views?", "\n\nI have somewhat unsuccessfully tried to figure out how to work with SwiftUI's ForEach view. ", "By following resources such as this, this and this, it seems to me that given an array of strings:\nvar arrayOfStrings: [String] = [\"String1\", \"String2\", \"String3\"]\n...each of the following implementations should work:\nForEach(arrayOfStrings, id: \\.self) {\n Text(arrayOfStrings[$0])\n}\n\nForEach(1...arrayOfStrings.count, id: \\.self) {\n Text(arrayOfStrings[$0])\n}\n\nForEach(arrayOfStrings, id: \\.self) { string in\n Text(string)\n}\n\nYet each of them gives me a compile-time error or crashes the app at runtime.", "\nThe above is just example code, but if you need the full context of what I am trying to do, here it is:\nstruct Infobox<Content>: View where Content: View {\n let edgeSize: CGFloat = 8\n let color: Color = .neoblå\n let content: Content\n\n var body: some View {\n VStack(spacing: 0) {\n BoxSide(.top, withColor: color)\n .frame(height: edgeSize)\n .padding(.horizontal, 0)\n\n content\n .background(color)\n\n BoxSide(.bottom, withColor: color)\n .frame(height: edgeSize)\n .padding(.horizontal, 0)\n }\n }\n\n init(@ViewBuilder _ content: @escaping () -> Content) {\n self.content = content()\n }\n\n init<T: View>(withHeader headerText: String, forContentArray contentArray: [(text: String, value: String)], splitInTwoColumns twoColumns: Bool, @ViewBuilder ignoreTheClosure: @escaping () -> T) where Content == VStack<TupleView<(HStack<TupleView<(Spacer, Text, Spacer)>>, HStack<TupleView<(VStack<ForEach<ClosedRange<Int>, Int, Text>>, VStack<ForEach<ClosedRange<Int>, Int, Text>>, Spacer, VStack<ForEach<ClosedRange<Int>, Int, Text>>, VStack<ForEach<ClosedRange<Int>, Int, Text>>)>>)>> {\n\n var column1: [String] = []\n var column2: [String] = []\n var column3: [String] = []\n var column4: [String] = []\n\n let halfArray = contentArray.count/2\n for (index, content) in contentArray.enumerated() {\n if index+1 <= halfArray {\n column1.append(content.text)\n column2.append(content.value)\n } else {\n column3.append(content.text)\n column4.append(content.value)\n }\n }\n\n self.init() {\n\n VStack(alignment: .leading) {\n HStack() {\n Spacer()\n Text(headerText)\n .font(.headline)\n Spacer()\n }\n HStack {\n VStack {\n ForEach(column1, id: \\.self) {\n Text(column1[$0])\n }\n }\n VStack {\n ForEach(column2, id: \\.self) {\n Text(column2[$0])\n }\n }\n Spacer()\n VStack {\n ForEach(column3, id: \\.self) {\n Text(column3[$0])\n }\n }\n VStack {\n ForEach(column4, id: \\.self) {\n Text(column4[$0])\n }\n }\n }\n }\n }\n }\n}\n\nSummary: Given an array of (String, String), create an Infobox() consisting of Text() elements divided into four columns (two for \"keys\" and two for the corresponding values).", "\nIf anyone has any ideas of how to fix those ForEach views, I'll give you a cookie :)\n\nA:\n\nThis one fails because $0 is a String and you cannot index your string-array with a string \nForEach(arrayOfStrings, id: \\.self) {\n Text(arrayOfStrings[$0])\n}\n\nThis one fails because array indices are 0-based -> Choose a 0 base range: 0..<arrayOfStrings.count to avoid an \"Index-out-of-bounds exception\"\nForEach(1...arrayOfStrings.count, id: \\.self) {\n Text(arrayOfStrings[$0])\n}\n\nThis one is generally correct, but you may have to reference your member scope-qualified self.arrayOfStrings this applies to all SwiftUI code when your scope is a closure:\nForEach(arrayOfStrings, id: \\.self) { string in\n Text(string)\n}\n\nThis is a more Swifty-way of doing the array access via index: \nForEach(arrayOfStrings.indices) {\n Text(self.arrayOfStrings[$0])\n}\n\n" ]

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[ "/*\nTranslation from original CKEDITOR language files:\nCopyright (c) 2003-2014, CKSource - Frederico Knabben. ", "All rights reserved.", "\nFor licensing, see LICENSE.html or http://ckeditor.com/license\n*/\nCKEDITOR.plugins.setLang(\"base64image\",\"de\",{\n\t\"alt\":\"Alternativer Text\",\n\t\"lockRatio\":\"Größenverhältnis beibehalten\",\n\t\"vSpace\":\"Vertikal-Abstand\",\n\t\"hSpace\":\"Horizontal-Abstand\",\n\t\"border\":\"Rahmen\"\n});" ]

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[ "Most developers I've talked to agree that the database is the most important component in a typical business application. ", "Yet, for years SQL Server database developers have used Administration tools shipping with SQL Server or a variety of 3rd party utilities. ", "Visual Studio, the Microsoft flagship development environment, was the domain of the VB.NET or C# developer. ", "TSQL support in Visual Studio was rudimentary at best.", "\n\nThat story changed last year with the advent of Visual Studio Team Services Database Edition. ", "VSTS Database Edition was a late addition to VSTS 2005 and was enhanced with the VSTS 2008 release. ", "I'm going to show you how you can incorporate VSTS Database Edition into your database development process.", "\n\nImportant, but not Sexy\n\nDatabases are not visually engaging. ", "Unless a database is not working, most application users don't see any part of a database. ", "Generally, databases don't interact with the outside world like a Web Service or an Application Control Library would.", "\n\nCompared to an Object Oriented-based application, database components are tightly coupled. ", "Tables are coupled to each other via foreign keys. ", "Views, functions, and stored procedures are tightly coupled to tables and each other. ", "Broken database code means a broken database or—even worse—corrupted data.", "\n\nA database is not like an assembly. ", "There is little you can do to version a SQL Server database like you would version an assembly. ", "Tight coupling and lack of versioning have other ramifications. ", "It's difficult for multiple developers to work on a database. ", "Aside from TSQL, there are other things to manage like Roles and object permissions. ", "Finally, you don't compile a database like you do an assembly.", "\n\nSimple and Specialized\n\nAlternately, Transact SQL code is pretty compact and specialized. ", "TSQL only does data. ", "There are no delegates, class hierarchies, or multi-threading features to support. ", "TSQL really serves only two roles: Data Definition (DDL), statements like ALTER and CREATE; and Data Manipulation (DML), statements like INSERT, UPDATE, and DELETE. ", "Because database code generally works in the database, there are fewer execution dependencies and test construction is easier than the many levels of testing you typically undergo with, for example, a Desktop or Web Application.", "\n\nVSTS Database Edition addresses the issues above and leverages the structure of TSQL, turning Visual Studio into a capable database development environment. ", "Now, I'll take you through a sample project so you can see VSTS Database Edition in action.", "\n\nCreating a Project\n\nFirst, the Database Edition only works with Visual Studio Team Suite. ", "To showcase the tools and simplify this article, I'm going to build the project from an existing database, rather than building a database from scratch.", "\n\nLike all Visual Studio development, database development is managed by using projects and solutions. ", "A project typically corresponds to a single database. ", "You can create SQL 2005 projects or SQL 2000 projects. ", "I've installed some additional Power Tools, so your install may look slightly different. ", "Figure 1 displays the SQL Server projects.", "\n\nAfter creating the project, it's important (but not required) to match project collation with the database collation. ", "Collation defines things such as ordering for text fields and case sensitivity. ", "Neglecting to set collation can lead to confusing warnings and errors. ", "Figure 2 shows where you set project collation on the project properties." ]

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[ "Milan Tučić\n\nMilan Tučić (born 15 August 1996) is a Slovenian football player who plays for OH Leuven in the Belgian First Division B.\n\nClub career\nTučić joined Rudar Velenje from Bravo in 2017 and went on to score 23 goals in 69 league appearances and also played in the 2018–19 UEFA Europa League qualifying rounds, scoring twice against Tre Fiori. ", "After playing two seasons at Rudar Velenje, he signed with the Belgian club OH Leuven on 2 September 2019.", "\n\nReferences\n\nExternal links\n Milan Tučić at NZS \n \n\nCategory:1996 births\nCategory:Living people\nCategory:Sportspeople from Ljubljana\nCategory:Slovenian footballers\nCategory:Association football forwards\nCategory:NK Bravo players\nCategory:NK Rudar Velenje players\nCategory:Oud-Heverlee Leuven players\nCategory:Slovenian PrvaLiga players\nCategory:Belgian Second Division/Belgian First Division B players\nCategory:Slovenian expatriate footballers\nCategory:Expatriate footballers in Belgium\nCategory:Slovenian expatriate sportspeople in Belgium\nCategory:Slovenia under-21 international footballers" ]

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[ "forrest-dev mailing list archives\n\nHi,\nI have a large document site with mixed docbook and regular\nforrest documentation.", "\nAfter I upgraded my site from 0.6 to 0.7, the docbook info does\nnot appear anymore on the site.", "\nI hit the link a menu only page shows up.", "\n<?", "xml version=\"1.0\" encoding=\"UTF-8\"?", ">\n<!", "DOCTYPE refentry PUBLIC \"-//OASIS//DTD DocBook XML V4.2//EN\"\n\"http://www.oasis-open.org/docbook/xml/4.2/docbookx.dtd\">\nAbove is the header of my files.", "\nIt's been a while since I dont play with the docs, I also moved the\ndoc to a windows station from\na Red Hat 9.0 installation.", "\nCan someone help me with this?", "\nJoao," ]

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[ "Regularly Scheduled Program\n\nSo it looks like the immigration bill is dieing fast and hard. ", "It was a mixed package and thus parts deserved to die and parts deserved to live, but the important thing is that this is just one more indication that Bush's political capital is gone, gone, gone.", "\n\nI think that Paris Hilton should be released and then dragged back to jail every few days just for the entertainment value.", "\n\nOh and we are still screwed in Iraq. ", "That has not changed in the last few days." ]

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[ "Democratic presidential candidate Bernie Sanders won Time magazine’s online reader poll for 2015 Person of the Year, but he didn’t even make the magazine’s final 8 contenders for actual Person of the Year, the publication announced Monday.", "\n\nDespite winning the popular vote, Time magazine didn’t let Sanders through to the next round. ", "Their eight finalists include: Abu Bakr Al-Baghdadi, Black Lives Matter activists, Caitlyn Jenner, Travis Kalanick, Angela Merkel, Vladimir Putin, Hassan Rouhani and Donald Trump.", "\n\nSanders won just over 10 percent of the vote, beating out world leaders, celebrities, and athletes. ", "Malala Yousafzai, an advocate for girls’ education in Pakistan, won second with 5.2 percent of the vote. ", "Pope Francis was third with 3.7 percent of the vote. ", "None of them made the final eight.", "\n\nRepublican presidential candidate won 1.8 percent of the vote and Democratic presidential candidate Hillary Clinton got 1.4 percent. ", "Republican presidential candidates Marco Rubio and Carly Fiorina received 1.1 percent and 0.6 percent, respectively. ", "Jeb Bush trailed with half a percent.", "\n\nTime said a presidential candidate has never won person of the year. ", "Time editor’s will pick the winner, and announce it Wednesday.", "\n\nFollow Casey on Twitter and like him on Facebook\n\nContent created by The Daily Caller News Foundation is available without charge to any eligible news publisher that can provide a large audience. ", "For licensing opportunities of our original content, please contact licensing@dailycallernewsfoundation.org.", "\n\nContent created by The Daily Caller News Foundation is available without charge to any eligible news publisher that can provide a large audience. ", "For licensing opportunities of our original content, please contact licensing@dailycallernewsfoundation.org." ]

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[ "Here is an epoxy sand eel pattern I find effective. ", "I'm sure there has been hundreds of sand eels tied similar to this but this just happens to be the way I tie it. ", "Friends of mine have caught bonito and FA at Martha's Vineyard on them but I haven't had the opportunity to chase those fish and give it a try myself yet there.", "\n\n...I'm sure there has been hundreds of sand eels tied similar to this but this just happens to be the way I tie it.", "\n\nVery nice. ", "As an aside, whenever I come up with a pattern at the vise, I often think it's worthless to give it some name or say that I developed it since it seems that much of what I do has already been done by someone somewhere. ", "Who cares though, as long as it catches fish!" ]

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[ "Data and analysis scripts are publicly available (<https://doi.org/10.5281/zenodo.3695583>).", "\n\nIntroduction {#sec001}\n============\n\nNatural sounds are often characterized by a rhythm that enables the listener to predict and prepare for relevant events \\[[@pone.0234251.ref001]\\], a finding confirmed by many studies probing the effects of periodicity and predictability on sound perception \\[[@pone.0234251.ref002]--[@pone.0234251.ref007]\\]. ", "Recent results have shown that periodicity and predictability of rhythms have dissociable effects on reaction time and sensitivity. ", "Periodic (isochronous) stimuli decrease the reaction time \\[[@pone.0234251.ref003],[@pone.0234251.ref008],[@pone.0234251.ref009]\\], even when their rhythm is not predictive of a target \\[[@pone.0234251.ref010],[@pone.0234251.ref011]\\]. ", "On the other hand, predictability can increase perceptual sensitivity \\[[@pone.0234251.ref005],[@pone.0234251.ref007],[@pone.0234251.ref012],[@pone.0234251.ref013]\\] even when stimulus presentation is predictable but aperiodic \\[[@pone.0234251.ref006],[@pone.0234251.ref014]\\].", "\n\nMost previous studies have focused on broadband or a few selected frequencies and have often tested presentation rates around 1.5 Hz \\[[@pone.0234251.ref004],[@pone.0234251.ref008],[@pone.0234251.ref015]--[@pone.0234251.ref019]\\]. ", "This last choice is at odds with studies suggesting that the brain preferentially differentiates acoustic information covering a range of timescales through theta- (and gamma) frequency-band information \\[[@pone.0234251.ref020]\\], a result that highlights the relevance of the temporal modulations inherent in speech occurring at the syllabic-level \\[[@pone.0234251.ref021],[@pone.0234251.ref022]\\]. ", "The importance of testing multiple carrier frequencies and presentation rates is stressed by psychoacoustic studies on amplitude modulation suggesting that rate and carrier frequency interact \\[[@pone.0234251.ref023]\\]. ", "To account for the interdependency between spectral and temporal processing, it has been suggested that the modulation filters modelling the auditory system \\[[@pone.0234251.ref024]\\] systematically change along the frequency axis. ", "In particular, the auditory system may be optimized to track rapid modulations at high frequencies and slower modulations at lower carrier frequencies \\[[@pone.0234251.ref025]\\].", "\n\nElectrophysiological recordings in macaque auditory cortex suggest that the mechanism engaged by rhythmic sound processing is tonotopic and thus cannot be investigated when using broadband noise bursts \\[[@pone.0234251.ref026]\\], but requires the use of narrow-band stimuli or tones \\[[@pone.0234251.ref016],[@pone.0234251.ref027]\\]. ", "These studies propose that the optimization of behavioral performance for periodic stimuli is achieved through the entrainment of neuronal oscillations, which temporally modulate the excitability of task-relevant neuronal populations \\[[@pone.0234251.ref008],[@pone.0234251.ref018],[@pone.0234251.ref028],[@pone.0234251.ref029]\\]. ", "Rhythmic external stimuli can entrain oscillations, during which neural delta \\[[@pone.0234251.ref008]\\] and theta oscillations \\[[@pone.0234251.ref030]\\] become aligned to the externally imposed rhythm. ", "The entrained oscillations may form the basis of temporal predictions that can be beneficial for stimuli presented at the entrainment rhythm \\[[@pone.0234251.ref019],[@pone.0234251.ref031]\\].", "\n\nPredictions can also be formed without periodicity, by using temporally cued associations. ", "The behavioral benefits of temporal cueing have been shown in studies on foreperiod effects \\[[@pone.0234251.ref032],[@pone.0234251.ref033]\\]. ", "At the behavioral level, a predictable rhythmic sequence should lead to better perceptual discrimination at predicted moments in time than a predictable single interval. ", "This has been tested in foreperiod-paradigms where the duration of an interval is judged, either in isolated pairs or with a preceding rhythm, and results indicate that discrimination thresholds improve \\[[@pone.0234251.ref013]\\]. ", "Studies focusing on reaction times have compared effects of temporal cueing and periodic stimulus presentation both when the predictive information was provided symbolically, showing a benefit of periodicity over symbolic cueing \\[[@pone.0234251.ref034]\\], and temporally cued not showing a difference \\[[@pone.0234251.ref015],[@pone.0234251.ref035]\\] and suggest a cumulative benefit of combining a temporal cue and a periodic rhythm \\[[@pone.0234251.ref003]\\]. ", "Similarly, studies using pitch discrimination tasks \\[[@pone.0234251.ref036],[@pone.0234251.ref037]\\] have shown effects on accuracy and reaction times. ", "Moreover, a benefit in accuracy derived from implicit predictability in temporally cued intervals has been shown \\[[@pone.0234251.ref014]\\]. ", "In line with a recent study suggesting that delta-phase entrainment may relate differently to spectral-based and temporal sensitivity \\[[@pone.0234251.ref012]\\], it would be of interest to compare perceptual sensitivity and reaction times due to predictability derived from a periodic sequence and from a single acoustic temporal cue when using a temporal task. ", "This would allow evaluating if a single mechanism underlies predictive effects induced by both a temporal cue and a periodic sequence.", "\n\nIn two behavioral studies, we systematically address these open points by investigating how rhythm and carrier frequency of periodically presented sounds contribute to the behavioral benefits of rhythmic sound perception (Experiment 1). ", "In a pilot we compare a subset of these conditions to aperiodic sound sequences (see [S1 File](#pone.0234251.s001){ref-type=\"supplementary-material\"}). ", "In experiment 2 we compare periodic and aperiodic sound sequences and additionally test whether the predictive advantage afforded by periodicity exceeds the advantage afforded by a temporal cue (Experiment 2). ", "Based on previous findings \\[[@pone.0234251.ref006],[@pone.0234251.ref007],[@pone.0234251.ref012]\\] we expect a perceptual benefit in sensitivity and reaction times of periodic over aperiodic rhythms. ", "In addition, we hypothesize that a periodic rhythm should result in a benefit over a single temporal cue, especially when targets are presented close to perceptual threshold. ", "With regard to the difference between various periodic rhythms, we expect behavioral improvement to occur around the peaks of the external rhythm, as opposed to a general improvement due to periodic stimulation, in line with \\[[@pone.0234251.ref016]\\]. ", "In particular, we hypothesize that an external rhythm in the theta frequency range (\\~ 4 Hz), would result in improved behavioral performance compared to other presentation rates.", "\n\nMaterials & methods {#sec002}\n===================\n\nParticipants {#sec003}\n------------\n\nPrior to testing, participants were screened for normal hearing (≤ 20 dB) at audiometric test frequencies ranging from 0.25--8 kHz. ", "In experiment 1a and 1b, two sets of 20 participants each took part in the experiments. ", "Two participants were excluded, one due to failure to comprehend the task and one due to discomfort caused by the loudness of the stimuli, resulting in the abortion of the experiment. ", "As a result, we analyzed data collected from n = 19 participants for experiment 1a (15 females, 4 males) and 1b (12 females, 7 males) each, and n = 20 participants for experiment 2 (13 females, 7 males). ", "The size of n was determined based on studies reporting similar effect sizes \\[[@pone.0234251.ref006]\\]. ", "The Ethics Review Committee of the Faculty of Psychology and Neuroscience (ERCPN) at Maastricht University granted approval for all studies and all participants gave informed consent.", "\n\nStimuli & design {#sec004}\n----------------\n\nAll stimulus presentation scripts were written in Matlab (The MATHWORKS Inc., Natick, MA, 234 USA), using the Psychophysics toolbox \\[[@pone.0234251.ref038]\\]. ", "Sounds were created at a 44.1 kHz sampling rate, 16-bit resolution and delivered through Sennheiser HD650 headphones. ", "Data and analysis scripts are publicly available (<https://doi.org/10.5281/zenodo.3695583>). ", "Exemplary stimuli can be found here (<https://doi.org/10.5281/zenodo.3549376>). ", "Participants were seated in a sound-attenuated chamber. ", "Instructions were presented on a computer monitor and responses collected with a standard keyboard. ", "Participants were asked to detect a target; a temporal shift (TS) of a narrow-band sound embedded in a sequence of quintets. ", "Narrowband sounds were centered around carrier frequencies of 200 Hz, 1100 Hz, or 3100 Hz. ", "The passbands around the carriers were constructed using equivalent rectangular bandwidths (ERBS = 4; \\[[@pone.0234251.ref039]\\]). ", "Each passband consisted of a summation of 21 sinusoids with amplitude normalized to 1 and a random onset phase. ", "A quintet consisted of five 10ms narrowband sounds, each separated by 10ms (see inset 1 [Fig 1D](#pone.0234251.g001){ref-type=\"fig\"}). ", "Targets were constructed by shifting in time the third sound in a quintet (see inset 2 [Fig 1D](#pone.0234251.g001){ref-type=\"fig\"}). ", "Depending on the experiment, this shift was either fixed at 6ms (Experiment 1) or ranged between 1.5-7ms (Experiment 2; see [Table 1](#pone.0234251.t001){ref-type=\"table\"}). ", "In both experiments, during a trial and up to 1 second after a quintet sequence finished, participants could press a button upon detecting a TS or another button at the end of a sequence indicating they did not perceive a TS. ", "Quintet sequences had either a periodic or aperiodic repetition of quintets or occurred in the form of a temporal cue, where a single quintet cued the following quintet that possibly contained a TS. [", "Table 1](#pone.0234251.t001){ref-type=\"table\"} reports the design parameters for each experiment. ", "The distribution of TS was non-uniform such that TS occurred in 75% of the trials. ", "Targets appeared at one of 3 possible quintet positions within the periodic or aperiodic sequences, or in the cued quintet. ", "In experiment 1a targets TS were presented in quintet 9, 10 or 11 (e.g. occurring after 9, 10 or 11s for the 1 Hz rhythm). ", "With increasing rhythm, targets thereby occurred earlier in time within a sequence (the 9th quintet at 2 Hz occurs at 4.5 s). ", "Experiment 1b controls for the earlier occurrence of targets with increasing rhythm, by keeping the time until a TS constant across rhythm (a TS occurring in the 9th quintet at 1 Hz would occur in the 18th quintet at 2 Hz). ", "Similar to experiment 1b, TS occurred at a fixed time in both the pilot experiment preceding experiment 2 (see [S1 File](#pone.0234251.s001){ref-type=\"supplementary-material\"}), as well as in experiment 2 itself.", "\n\n{#pone.0234251.g001}\n\n10.1371/journal.pone.0234251.t001\n\n###### Design and overview of stimuli conditions.", "\n\n![](", "pone.0234251.t001){#pone.0234251.t001g}\n\n Temporal structure rhythm Trials/Blocks Carrier Task difficulty Motivation\n ------------ ------------------------ ------------ ------------------------------------------ ------------------------ ------------------------------ -------------------------------------------------\n **Exp 1a** Periodic 1,2,4,8 Hz 48 trials (12 per rhythm) \\*10 blocks 200 Hz 1100 Hz 3100 Hz 6 ms TS Test preferred rhythm and carrier\n **Exp 1b** Periodic 1,2,4,8 Hz 48 trials (12 per rhythm) \\*10 blocks 200 Hz 1100 Hz 3100 Hz 6 ms TS Rhythm effect in Exp 1a due to target position?", "\n **Exp 2** Periodic Aperiodic Cue 2 Hz 72 trials (24 per condition) \\* 6 blocks 1100 Hz 1.5--7 ms TS (70% threshold) Periodic benefit when more difficult task?", "\n\nIn experiment 1a (n = 19) & 1b (n = 19) we investigated the effect of periodic rhythms (1, 2, 4, 8 Hz) and the carrier frequency (200, 1100 and 3100Hz) on target detection sensitivity (measured in d') and reaction time. ", "Every trial consisted of 12s periodic sequences of quintets. ", "We conducted two versions of this experiment, in which we varied the position of the targets within the sequences. ", "In experiment 1a we kept the number of preceding quintets until the TS constant across rhythms. ", "This systematically reduced the time until a target appeared with increasing rhythm frequency. ", "In experiment 1b, we kept the time at which targets appeared constant, thereby presenting an increasing number of preceding quintets with increasing rhythms prior to presenting a target quintet. ", "The rationale to assess and compare these two experiment versions is that the strength of entrainment might increase with additional repetitions, and the effect of rhythm may be confounded by the systematic effect of target position in a sequence. ", "Trials were counter-balanced and randomized with respect to target position and carrier frequency, and presented in (counterbalanced) blocks per rhythm, consisting of 12 trials. ", "After four blocks (one per rhythm) subjects had a break. ", "In total participants received 10\\*4 blocks, summing to a total of 480 trials. ", "Subjects underwent a brief training session (8--12 trials) using a subset of the stimuli. ", "During training, visual feedback on the performance was provided. ", "Prior to the training and main experiment, participants adjusted the intensity of the sounds to equalize their perceived loudness. ", "When comparing the three carrier frequencies at equal intensities, 200 Hz was generally perceived as softer and 3100 Hz perceived as louder relative to the reference frequency of 1100 Hz and were adjusted accordingly. ", "These observations are in line with equal loudness contours \\[[@pone.0234251.ref039]\\].", "\n\nUnless explicitly stated, the stimuli in the pilot experiment preceding experiment 2 (see [S1 File](#pone.0234251.s001){ref-type=\"supplementary-material\"}) and stimuli in experiment 2 were identical to those used in experiment 1b. ", "We decided to limit the number of conditions and chose the carrier frequency and rhythm based on our findings in experiment 1 showing that with a 2 Hz rhythm and a 1100 Hz carrier frequency behavioral performance was intermediate, and thus we could expect the behavior to be modulated by the manipulations in experiment 2. ", "In the pilot (n = 20; 11 females, 9 males) we examined the effect of (average) rhythm on target detection, by comparing periodic predictable and aperiodic unpredictable sequences of quintets. ", "The TS target remained fixed at 6ms. ", "To create an aperiodic sequence, the main constraint was to present the same number of quintets in the same amount of time (compared to the periodic conditions) at aperiodic inter-stimulus intervals (ISIs). ", "For instance, the aperiodic sequence corresponding to the 1 Hz rhythm had to be comprised of 12 quintets in 12 seconds. ", "As a result, ISIs had to be sampled within two intervals, shorter or longer compared to the corresponding periodic condition. ", "Periodic sequences at 1Hz have a 1s ISI, the corresponding aperiodic condition sampled ISI from two distributions with mean equal to 250ms and 1500ms. ", "Similarly, periodic sequences at 2 Hz have a 500ms ISI, the corresponding aperiodic condition sampled ISI from two distributions with mean equal to 100ms and 733ms. ", "In each aperiodic condition, the average over both sampled distributions approximates the periodic condition (1.07 Hz and 2.2 Hz respectively). ", "Due to the nested temporal structure of the stimuli it was not possible to create aperiodic sequences at average rhythms of 4 Hz and 8 Hz, as the interval between quintets was too short. ", "The participants performed 80 trials of the target detection task on aperiodic stimuli. ", "Stimuli were presented in blocks of 16 trials, in which the average rhythm was constant.", "\n\nD' scores of the pilot experiment approached ceiling for many of the participants. ", "Therefore, in experiment 2 (n = 20; 13 females, 7 males) we adjusted the difficulty range of the task to capture a modulation of behavior by periodicity. ", "In addition, the stimuli were shortened to 6s, the (average) rhythm was fixed at 2 Hz and the carrier frequency at 1100 Hz, to limit the number of conditions and experiment duration. ", "Aperiodic stimuli in experiment 2 were created similar to aperiodic stimuli in the pilot. ", "Rhythmic stimuli (periodic predictable, aperiodic unpredictable) were compared to a temporal cue condition to test whether the predictive benefits derived from periodicity are larger than those derived from a single temporally predictive cue. ", "Trials were presented in blocks (grouped by condition periodic, aperiodic, cue); within each block, trials were randomized, and the block order was counterbalanced across participants. ", "Each participant completed a total of 432 trials. ", "Task difficulty was determined through a staircase procedure preceding every block of trials, in which TS were set to achieve a behavioral performance at 70% detection threshold, as determined by means of a 2 down 1 up procedure. ", "The termination criterion was after 200 trials or 15 reversals. ", "The TS varied on a fixed step-size of 10 logarithmically spaced steps between 7ms and 1.5 ms (see S3 Fig for average TS size per staircase preceding a block).", "\n\nStatistical analysis {#sec005}\n--------------------\n\nAll analyses were conducted in MATLAB 2017a (The MATHWORKS Inc., Natick, MA, 234 USA). ", "For each participant, the d' sensitivity index of signal detection theory and mean log-reaction times (logRT) of correct trials were calculated. ", "Reaction time was calculated relative to target onset.", "\n\nStatistical analysis of reaction times and sensitivity were carried out using a Generalized Linear Mixed Model (GLMM) with Matlab's *fitGLME* function. ", "We assessed the model fits using likelihood ratio tests (using the function *compare* for GLMM). ", "Contrasts were carried out performing an F-test on the specified fixed effects of the GLMM (using the function *coefTest*). ", "Reaction times were fitted using the default identity link function, unlike the fitting of the sensitivity data for which a probit link function was used as described in more detail below.", "\n\nTraditionally, d' is estimated by counting the frequency of an observer reporting 'yes' conditional on the presence and absence of a signal (i.e. the hit and false alarm rates) and taking the difference of these values on a z-transformed scale \\[[@pone.0234251.ref040]\\]. ", "In the present work, statistical group analyses on d' are carried out using a GLMM \\[[@pone.0234251.ref041]\\] We estimate both model parameters and d' simultaneously to determine the effect of carrier and target position, periodicity and temporal cueing on the population, rather than estimating d' on each condition separately and feeding the estimated values to a second level analysis. ", "This statistical framework extends multiple linear regression to non-normal data such as count data and binary outcomes and it is more suited to handle extreme cases (100% hits or 0% false alarms). ", "Within this framework, d' can be estimated by linearly modeling the behavioral outcomes (i.e. 'yes' or 'no') with a predictor *X* coding for the presence or absence of the target (see right side of [Eq (1)](#pone.0234251.e001){ref-type=\"disp-formula\"}; and \"Target\" predictor in [Table 2](#pone.0234251.t002){ref-type=\"table\"}). ", "To fit an equal-variance Gaussian signal detection model an inverse Gaussian (probit) link function is used, where *g* is the link function and *X* represents the presence or absence of the signal.", "\n\n![](", "pone.0234251.e001.jpg){#pone.0234251.e001g}\n\ng\n\n(\n\nE\n\n\\[\n\nPr\n\n(\n\nR\n\ne\n\ns\n\np\n\n=\n\n\\'\n\nY\n\ne\n\ns\n\n\\'\n\n)\n\n\\]\n\n)\n\n=\n\nβ\n\n0\n\n\\+\n\nβ\n\n1\n\nX\n\n10.1371/journal.pone.0234251.t002\n\n###### Wilkinson notation of final model in each experiment.", "\n\n![](", "pone.0234251.t002){#pone.0234251.t002g}\n\n ----------- -----------------------------------------------------------------------------------------------------------------------------\n **Exp 1** d' \\~ Criterion + Target\\*Rhythm\\*Carrier\\*Experiment + (1\\|Subject) logRT \\~ 1+ Rhythm\\*Carrier\\*Experiment + (1\\|Subject)\n **Exp 2** d' \\~ Criterion+ Target\\*temporalCondition + (1\\|Subject) logRT \\~ 1+ temporalCondition\n ----------- -----------------------------------------------------------------------------------------------------------------------------\n\nCriterion is an additional predictor reflecting the intercept (normally notated as 1, here re-parameterized to -1 to reduce correlation between fixed effects (see p 262, \\[[@pone.0234251.ref041]\\])\n\nWhen the signal is absent (i.e. *X* = 0), *β*~0~ provides an estimate of the normal quantile of the false alarm rate. ", "When the signal is present (i.e. *X* = 1), *β*~1~ reflects the difference between hit and false alarm rate on the probit scale (hence, the difference between z-scaled hit and false alarm rates), or d'. ", "The different experimental conditions are then added as predictors, and the estimated d' for each of these conditions (hence our effect of interest) is described by the interaction term between *X* ('target') and the respective condition predictor (see \\[[@pone.0234251.ref041]\\]chapter 3.3.5). ", "Unstandardized effect sizes (betas) are reported in units of the dependent variable (d ' or logRT), allowing for a meaningful comparison, in line with general recommendations on how to report effect sizes in psychological research \\[[@pone.0234251.ref042]\\].", "\n\nFor our visualization, we estimated d' as it is traditionally computed. ", "Standard errors of d' group effects displayed in Figs [2](#pone.0234251.g002){ref-type=\"fig\"} and [4](#pone.0234251.g004){ref-type=\"fig\"} were obtained by non-parametric bootstrap sampling of estimated d' values, carried out at the subject level (N = 1000). ", "The mean was used as a measure of central tendency around which 95% confidence intervals were created. ", "All planned contrasts were corrected for multiple comparisons, using Bonferroni correction.", "\n\n{#pone.0234251.g002}\n\nResults {#sec006}\n=======\n\nComparing periodic sequences at different carrier frequencies (experiment 1) {#sec007}\n----------------------------------------------------------------------------\n\nWe investigated the benefits in perceptual sensitivity and reaction times associated with rhythmic sound presentation as a function of the rhythm and the carrier frequency in two experiment variants in which we varied the target position within a sequence (Experiment 1a and 1b). ", "The data from both experiments were fitted using a single large GLMM (see [Table 2](#pone.0234251.t002){ref-type=\"table\"} for final notation of model).", "\n\n### Slow entraining rhythms improve target detection {#sec008}\n\nThe analysis showed a significant interaction of experiment and rhythm on d' (F (3,864) = 4.528, p \\< 0.01), (see [Table 3](#pone.0234251.t003){ref-type=\"table\"}). ", "Therefore, we analyzed the effect of rhythm separately for experiment 1a and 1b, revealing an effect of rhythm on sensitivity in both, experiment 1a ([Fig 2A](#pone.0234251.g002){ref-type=\"fig\"}), F (3,432) = 9.3704.19, p \\< 0.001) as well as experiment 1b ([Fig 2B](#pone.0234251.g002){ref-type=\"fig\"}), (F (3,432) = 26.083, p \\< 0.001). ", "Follow-up tests showed, for both experiment variants, a parametric effect of rhythm on sensitivity (see [Table 4](#pone.0234251.t004){ref-type=\"table\"}). ", "Counter to our hypothesis of an inverted U-shape where 4 Hz would perform best, we observed a parametric effect of rhythm. ", "The slowest rhythms (1 Hz & 2 Hz) led to significantly higher sensitivity compared to the fastest (8 Hz) in both experiments. ", "In addition, in experiment 1b the slowest rhythms (1 Hz & 2 Hz) led to significantly better sensitivity than 4 Hz as well. (", "see [Table 4](#pone.0234251.t004){ref-type=\"table\"} for specific contrasts). ", "We did not observe this parametric effect of rhythm on reaction times ([Fig 3](#pone.0234251.g003){ref-type=\"fig\"}) (F (3,431) = 2.498 p \\>0.05).", "\n\n{#pone.0234251.g003}\n\n10.1371/journal.pone.0234251.t003\n\n###### Planned contrasts sensitivity.", "\n\n![](", "pone.0234251.t003){#pone.0234251.t003g}\n\n β F p\n ---------------------------- ------------- ----------------------- ---------------\n (2 Hz-1 Hz):Experiment -0.8656 F(1, 864) = 4.66 p\\>0.05\n **(4 Hz-1 Hz):Experiment** **-1.3884** **F(1, 864) = 12.82** **p\\<0.01**\n **(8 Hz-1Hz):Experiment** **-1.1338** **F(1, 864) = 8.67** **p \\<0.05**\n (4 Hz-2 Hz):Experiment -0.5228 F(1, 864) = 2.63 p\\>0.05\n (8 Hz-2 Hz):Experiment -0.2682 F(1, 864) = 0.71 p\\>0.05\n (8 Hz-4 Hz):Experiment 0.2546 F(1, 864) = 0.71 p\\>0.05\n 200 Hz- 1100 Hz 0.0983 F(1, 864) = 0.18 p\\>0.05\n **200 Hz-3100 Hz** **0.9364** **F(1, 864) = 19.42** **p \\<0.001**\n **1100 Hz-3100 Hz** **-0.8381** **F(1, 864) = 14.92** **p \\<0.001**\n\nEstimates are in d'. ", "1 Hz and 1100 Hz are reference categories for dummy coding scheme. ", "Bold values indicate statistically significant results. ", "p \\< 0.05, Bonferroni corrected. ", "Each row refers to a contrast that interacts with the target predictor.", "\n\n10.1371/journal.pone.0234251.t004\n\n###### Planned contrasts of rhythm per experiment.", "\n\n![](", "pone.0234251.t004){#pone.0234251.t004g}\n\n contrasts β F p\n ------------------- ------------- ----------------------- ------------------ ---------\n **Experiment 1a** (2 Hz-1 Hz) 0.0750 F(1, 432) = 0.10 p\\>0.05\n (4 Hz-1 Hz) -0.4874 F(1, 432) = 4.13 p\\>0.05 \n **(8 Hz-1 Hz)** **-1.0152** **F(1, 432) = 19.29** **p \\<0.001** \n (4 Hz-2 Hz) 0.5624 F(1, 432) = 5.24 p\\>0.05 \n **(8 Hz-2 Hz)** **1.0903** **F(1, 432) = 21.13** **p\\<0.001** \n (8 Hz-4 Hz) 0.5279 F(1, 432) = 5.07 p\\>0.05 \n **Experiment 1b** (2 Hz-1 Hz) -0.7902 F(1, 432) = 6.11 p\\>0.05\n **(4 Hz-1 Hz)** **-1.8744** **F(1, 432) = 37.83** **p\\<0.001** \n **(8 Hz-1 Hz)** **-2.1465** **F(1, 432) = 48.59** **p\\<0.001** \n **(4 Hz-2 Hz)** **1.0842** **F(1, 432) = 26.97** **p\\<0.001** \n **(8 Hz-2 Hz)** **1.3563** **F(1, 432) = 40.41** **p\\<0.001** \n (8 Hz-4 Hz) 0.2721 F(1, 432) = 2.05 p\\>0.05 \n\nEstimates are in d'. ", "1 Hz and 1100 Hz are reference categories for dummy coding scheme. ", "Bold values indicate statistically significant results. ", "p \\< 0.05, Bonferroni corrected. ", "Each row refers to a contrast that interacts with the target predictor.", "\n\n### Carrier frequency of the stimulus affects target detection and reaction time {#sec009}\n\nWe observed a parametric main effect of carrier frequency on sensitivity F (2,864) = 12.2, p\\<0.001). ", "Participants were more sensitive in detecting a target when listening to a sequence with a 200 Hz carrier compared to the high carrier frequency at 3100 Hz (beta = -0.9364; F (1, 864) = 19.42, p = \\<0.001), but also when comparing the 1100 Hz carrier against 3100 Hz carrier (beta = -0.8381; F (1, 864) = 14.92, p\\<0.001). ", "The difference in sensitivity between the 200 Hz and 1100 Hz was not significant (beta = 0.0983; F (1, 864) = 0.18). ", "In addition, we observe that the carrier frequency had a significant effect on logRT (F (2,431) = 7.539, p\\< 0.001). ", "Comparisons showed that the lowest carrier frequency led to significantly faster responses compared to the middle carrier (beta = -0.1078; F (1, 431) = 5.87, p\\<0.05), and the highest carrier frequency (beta = -0.1709; F (1, 431) = 14.74, p\\<0.001) ([Fig 3](#pone.0234251.g003){ref-type=\"fig\"}).", "\n\n### Carrier Frequency and rhythm do not interact in their effects on sensitivity and reaction time {#sec010}\n\nThe interaction of rhythm by carrier was not significant in reaction times (F (6,431) = 1.125, p \\> 0.05) or sensitivity (F (6,864) = 2.0454, p \\> 0.05).", "\n\nEffect of (a)periodic sequences and a temporal cue at perceptual threshold (experiment 2) {#sec011}\n-----------------------------------------------------------------------------------------\n\nExperiment 2 compared the effect of periodic predictable and aperiodic unpredictable sequences of 6 second length to a temporal cueing condition with a cueing interval matching the ISI of the sequences (500ms). ", "We fitted two GLMMs for the reaction time data and d' data respectively. ", "Each model consisted of the fixed-effect within-subject factor *temporal structure* (3 levels; periodic, aperiodic, cue).", "\n\n### Temporally predictable stimulation (through a periodic rhythm or a cue) improves sensitivity {#sec012}\n\nWe compared target detection sensitivity in three temporal context conditions: predictable periodic, unpredictable aperiodic, (predictable) temporal cue. ", "We found d' to vary significantly as a function of temporal context ([Fig 4A](#pone.0234251.g004){ref-type=\"fig\"}, F (2, 114) = 52.663, p\\< 0.001). ", "Comparisons between the conditions revealed significant differences in d' between the predictable periodic and unpredictable aperiodic sequences (beta = 0.5903; t (1, 114) = 7.95, p\\< 0.001), as well as between the aperiodic sequence and the temporal cue (beta = 0.7154; t (1, 114) = 9.3612, p\\<0.001). ", "The difference in d\\' between predictable periodic sequences and the temporal cue was not significant (beta = 0.1251; F (1, 114) = 2.49, p\\>0.05).", "\n\n{#pone.0234251.g004}\n\n### Predictable temporal cue and a predictable periodic sequences improve reaction time compared to an aperiodic unpredictable sequence {#sec013}\n\nThe analysis of reaction times yielded a significant, yet different pattern between conditions ([Fig 4B](#pone.0234251.g004){ref-type=\"fig\"}, F (2, 57) = 48.1, p\\< 0.01). ", "Comparisons revealed faster correct responses for periodic predictable than aperiodic unpredictable sequences (beta = -0.3317; t (1, 57) = -4.894, p\\< 0.001). ", "Moreover, participants responded faster to temporally cued targets than periodic rhythms, (beta = -0.3331; F (1, 57) = 24.15, p\\<0.001) as well as aperiodic (beta = -0.6647; t (1,57) = 9.808, p\\<0.001) rhythms. ", "Thus, temporal predictability (whether through a cue or a periodic rhythm) led to an improvement of auditory sensitivity, while participants additionally benefit in their response times from the periodicity of stimulation compared to aperiodic stimulation, and a temporally predictable cue leading to the fastest response.", "\n\nDiscussion {#sec014}\n==========\n\nUsing a temporal shift detection task we asked how the rate and the carrier frequency of a predictable periodic rhythm influence both reaction time and sensitivity of perceptual decisions. ", "Moreover, we asked whether the predictive advantage derived from periodic stimulation is larger than that afforded by aperiodic stimulation or a single temporal cue. ", "The data show that (1) the largest sensitivity improvement is observed for the slowest rhythm (1 Hz); (2) sensitivity improvement is larger for low-frequency (200 Hz) carriers compared to 1100 Hz and 3100 Hz carriers; (3) periodic stimulation significantly reduces reaction times compared to aperiodic stimulation (speeded responses were observed both at perceptual threshold as well as above threshold during the pilot experiment); (4) a response to a temporal cue is faster than a response to periodic stimulation (5) periodic stimulation and cueing significantly increase sensitivity compared to aperiodic stimulation.", "\n\nExperiment 1. ", "Largest sensitivity improvements occur at slowest rhythm {#sec015}\n----------------------------------------------------------------------\n\nPsychophysical findings show that sensitivity towards amplitude modulation detection of noise is highest for humans in the (speech) range of 2--4 Hz, while highest for macaques in the range of 30--60 Hz \\[[@pone.0234251.ref043]\\]. ", "These and other findings have led to the notion that the human auditory cortex is considered to be speech-ready, therefore, we expected a peak in perceptual sensitivity with periodic sound presentation around 4 Hz. ", "However, our results show that listeners' performance was highest at a slow rhythm and decreased with increasing rate of rhythm. ", "A similar pattern of preference for slow rhythms (e.g. 2 Hz) as opposed to faster rhythms (8 Hz) has also been shown for cortical synchronization (entrainment) to speech in noise. ", "Phase-locking of neural activity to speech embedded in noise decreased from low (2 Hz) to high (8 Hz) frequencies, correlating with speech intelligibility \\[[@pone.0234251.ref044]\\]. ", "This pattern resembles the linear decrease across rhythms observed here and supports the predominant role of delta band frequencies in auditory processing.", "\n\nMoreover, we speculate that our findings may relate to the nature of the task and stimuli we used. ", "The acoustic features of the isochronous stimuli may be closer to music and its temporal modulations than to the modulations inherent in speech. ", "Temporal modulations in western music peak between 0.5 and 3 Hz, depending on the instrument and may contribute to a preference for slower modulations. ", "As to why the peak of the modulation spectrum in music may be lower than that of spoken speech, it has been suggested that music like language is limited by the dynamic rate of movement of the effector (i.e. the frequency range where movement is most efficient; usually hands and arms in the case of music and articulators in the case of language) \\[[@pone.0234251.ref021]\\]. ", "Slow rhythms (1 Hz and 2 Hz) approximate the rate of spontaneous, hence most efficient, motor tempo (around 1.5 Hz for adults) as measured by spontaneous tapping-tasks \\[[@pone.0234251.ref045]\\]. ", "A recent review substantiates the link between auditory processing and the motor system, suggesting a downward propagation of temporal predictions from the motor system involving delta-oscillations that shape auditory perception by imposing temporal constraints \\[[@pone.0234251.ref046]\\].", "\n\nLastly, we show that reaction times were not modulated by different rhythms. ", "Preparatory response processes are typically studied in foreperiod (FP)---reaction time experiments, in which it is a classical finding that both the duration of the FP (usually in the range of seconds) as well as the variability of FP across trials within a block have a considerable effect on reaction times \\[[@pone.0234251.ref033]\\]. ", "In the present study, ISI within a block were constant (i.e. low variability across trials), allowing the participant to prepare a motor response equally probable across conditions. ", "Moreover, the absence of a difference in reaction times suggests that the time-range tested here allowed for non-specific (motor) preparations across all rates. ", "Despite no difference in reaction times across rates, a difference in sensitivity across rates was observed, highlighting the perceptual benefit of rhythmic sound presentation, especially for slower rhythms.", "\n\nExperiment 1. ", "Carrier-dependent improvement of sensitivity and reaction times {#sec016}\n-----------------------------------------------------------------------------\n\nSurprisingly, we found that the sensitivity decreased with increasing the carrier frequency. ", "Based on the literature on temporal modulation processing in humans, we would expect higher sensitivity for higher carrier frequencies, as sounds are encoded by auditory spectral filters (tonotopic mechanism). ", "These spectral filters are narrower at lower frequencies and wider at higher frequencies and limit the temporal resolution of the auditory system. ", "Therefore detection performance of a temporal shift should decrease at lower carrier frequencies where the bandwidth is narrower \\[[@pone.0234251.ref047]\\]. ", "Indeed, increasing modulation detection thresholds for decreasing center frequencies have been observed \\[[@pone.0234251.ref048],[@pone.0234251.ref049]\\]. ", "We controlled for this effect, by adjusting the stimuli to have equivalent rectangular bandwidth (ERB) and equivalent perceived intensity. ", "Despite this equalization we observe an effect of carrier frequency. ", "We suggest that the perceptual benefit at the low carrier frequency may be a product of temporal coding mechanisms. ", "Phase locking up to 250 Hz has been observed in human intracortical recordings using click trains \\[[@pone.0234251.ref050]\\]. ", "This temporal encoding seems to provide a perceptual benefit when making judgments about the presence of a temporally shifted target thereby improving sensitivity. ", "Additionally, this benefit in sensitivity for the lowest carrier frequency was accompanied by an increase in response speed. ", "Simpson, Reiss and McAlpine \\[[@pone.0234251.ref025]\\] estimated sensitivity to a range of amplitude modulation frequencies (0.5 Hz to 33 Hz) across a large number of frequency carriers including and beyond the range of carriers tested here. ", "Their results suggest that at low carrier frequencies cortical modulation filters are most sensitive to slow modulation rates, similar to the rates used here (1--8 Hz). ", "They speculate that such a frequency-dependent modulation tuning is related to the neural processing of acoustic properties of speech \\[[@pone.0234251.ref051]\\]. ", "Lastly, these findings suggest that behavioral effects of entrainment, may depend on the type of spectral stimulation used for entraining and probing, which may be especially relevant in the context of spectral tasks \\[[@pone.0234251.ref026]\\].", "\n\nExperiment 1. ", "Effect of rhythm not confounded by target position {#sec017}\n----------------------------------------------------------------\n\nThe number of preceding quintets was varied between experiment 1a and 1b. ", "In experiment 1a we kept the number of preceding quintets until the TS constant across rhythms. ", "This systematically reduced the time until a target appeared with increasing rhythm. ", "In experiment 1b, we kept the time at which targets appeared constant across rhythms, thereby presenting an increasing number of preceding quintets with increasing rhythms prior to presenting a target quintet. ", "Our rationale to assess and compare these two experiment versions being, that the strength of entrainment might increase with additional repetitions. ", "The effect of rhythm would then be confounded by the systematic effect of target position in a sequence. ", "Indeed, we show in experiment 1a as well as 1b an effect of rhythm. ", "By having controlled the position of the target across the different presentation rates we therefore conclude that there is a difference between rhythms and said effect was not confounded by the systematic effect of target position in a sequence. ", "In experiment 2 targets embedded in aperiodic and periodic sequences occurred late within a sequence (similar to Experiment 1b). ", "It would be interesting to see what the effect of aperiodic and periodic sequences is when targets are presented earlier. ", "We may speculate that this would further enhance the detection difficulty of the task enhancing the benefit of periodicity.", "\n\nExperiment 2. ", "Effects of periodicity and cueing diverge in logRT and sensitivity {#sec018}\n--------------------------------------------------------------------------------\n\nThe results of experiment 2 show that both perceptual sensitivity and reaction times are improved when stimuli are presented in periodic rhythms compared to aperiodic rhythms, when using a temporal detection task at perceptual threshold. ", "Note that these effects are only apparent when controlling for task difficulty. ", "In a pilot study, where this was not done, we did not observe an effect of periodicity on sensitivity (see [S1 File](#pone.0234251.s001){ref-type=\"supplementary-material\"}). ", "The results of experiment 2 support earlier findings reporting a benefit of predictability in periodic over aperiodic stimulation \\[[@pone.0234251.ref004]--[@pone.0234251.ref007],[@pone.0234251.ref052]--[@pone.0234251.ref055]\\]. ", "This is in line with the idea of oscillatory entrainment and dynamic attending theory \\[[@pone.0234251.ref056]\\] and highlights the relevance of using a task with sufficient difficulty, in contrast to the pilot. ", "However, this finding points to a more general question of the benefit of entrainment in everyday life as most stimuli we encounter are seldom at perceptual threshold.", "\n\nIn addition, we were interested in contrasting the benefit in reaction times and sensitivity of a predictable periodic rhythm to a predictable (but not periodic) temporal cue. ", "We expected a benefit in reaction times similar to \\[[@pone.0234251.ref006]\\] (albeit different) showing a benefit of a periodic predictable sequence over an aperiodic, predictable condition of increasing tempo. ", "Moreover, we expected a benefit in sensitivity for the periodic rhythm compared to the temporal cue. ", "We show in experiment 2, that a temporal cue enables a participant to respond significantly faster than a periodic rhythm, while there is no difference in perceptual sensitivity between these two forms of temporal structure. ", "The cue predicts target occurrence with a 75% validity (25% of trials were catch-trials without a target). ", "Similarly, the periodic rhythm allowed participants to predict when a subsequent target may occur with a similar validity for the trial. ", "Yet participants were faced with the additional uncertainty as to which quintet within a sequence may contain the target. ", "This uncertainty may be the reason for the observed slowing of reaction times in the periodic condition compared to the cue. ", "The greater effectiveness of the temporal cue compared to the rhythm in terms of reaction time suggests that the temporal cue induced a more confident temporal expectation, in line with the finding that target-occurrence uncertainty impairs reorienting, thereby lengthening of reaction times \\[[@pone.0234251.ref057]\\]. ", "It would be of interest to compare these two conditions under similar uncertainty of target occurrence.", "\n\nInterestingly though, despite said larger uncertainty the periodic condition is not significantly worse than the temporal cue in terms of sensitivity, therefore we suggest that a benefit of a periodic rhythm to some extent countered the increased uncertainty. ", "Ten Oever et al. ", "have shown that entrainment of low-frequency oscillations in the delta---range serves a mechanistic role in enhancing perceptual sensitivity of subthreshold periodic, predictable sound sequences compared to aperiodic sequences \\[[@pone.0234251.ref018]\\]. ", "Under the hypothesis that oscillations align more efficiently to a rhythmic structure as compared to a single interval, it is surprising that the periodic sequences here did not result in a sensitivity benefit over the temporal cue. ", "See for instance \\[[@pone.0234251.ref058],[@pone.0234251.ref059]\\]showing an accuracy benefit of periodic sequence over cue in duration estimation. ", "We speculate that the additional uncertainty of when within a sequence a target may occur, may have countered a benefit of the entraining rhythmicity of the sequence. ", "Again, it would be of interest to compare instances of a predictable periodic rhythm and a predictable temporal cue conveying the same uncertainty. ", "We would then predict sensitivity of the periodic predictable condition to be higher than the temporal cue condition.", "\n\nAt the neurophysiological level, we speculate that such a mechanism might be implemented by a more flexible phase reset model of neuronal oscillations \\[[@pone.0234251.ref015],[@pone.0234251.ref060],[@pone.0234251.ref061]\\], (see \\[[@pone.0234251.ref062]\\], for a recent review), in which the motor system tracks temporal regularities \\[[@pone.0234251.ref046]\\]. ", "Further research will be necessary to elucidate the mechanism and nature of top-down predictions and how these affect auditory perception.", "\n\nConclusion {#sec019}\n==========\n\nWe show that overall temporal modulations in the range of 1--8 Hz are better processed at lower carrier frequencies, as measured by reaction times and sensitivity (experiments 1a and 1b). ", "Additionally, the same results point to the perceptual benefit of slow rhythms (1 and 2 Hz) over faster ones (4 and 8 Hz). ", "The regularity of rhythms enables the use of prediction to make more precise inferences about when we should expect to find a target embedded within the stream and, as a result, improve detection performance. ", "Indeed, we show in experiment 2 a perceptual benefit of periodic predictable sequences over aperiodic unpredictable sequences in terms of reaction times and sensitivity (the latter only present when using a sufficiently difficult task). ", "Crucially, in experiment 2 we show that the predictive value of a cue and that of a temporal rhythm do not differ in terms of the sensitivity in detecting a target, albeit it has to be noted that the periodic condition contained a larger uncertainty where the target would appear. ", "These findings encourage us to reflect on what the perceptual benefits of periodicity and predictability respectively are, as these effects may diverge when teased apart using different tasks thereby allowing to make assumptions about the underlying mechanisms involved. ", "Here we showed that both the cue and the rhythm induce confident temporal expectancies about the future occurrence of targets to effectively prepare and allocate attentional resources. ", "Taken together, we may speculate that multiple processes may co-occur that facilitate the processing of rhythmic and predictable stimuli, in which oscillations form an intrinsic temporal constraint, controlled by temporal predictions. ", "Potentially, cueing effects occur due to a single phase-reset of ongoing oscillations and similarly a rhythmic benefit occurs due to either a stimulus driven entrainment of oscillations or repeated top-down phase resets.", "\n\nSupporting information {#sec020}\n======================\n\n###### \n\n(DOCX)\n\n###### \n\nClick here for additional data file.", "\n\nThe authors thank Jacek Chudy and Louisa Zielke for help with data collection. ", "We thank Sanne ten Oever for feedback on the manuscript and the reviewers for their valuable comments that helped improve this work. ", "This work was funded by The Netherlands Organization for Scientific Research (NWO) Research Talent Grant 406.17.200 awarded to MH, EF and PdW. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.", "\n\n[^1]: **Competing Interests:**The authors have declared that no competing interests exist.", "\n" ]

{ "pile_set_name": "PubMed Central" }

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[ "In Focus\n\nEnglish\n\nAn introduction to Firsova's music by Gerard McBurney\n\nThe essential qualities of Elena Firsova’s music were established almost from the very beginning of her composing life. ", "Even in her student days she was already an unashamedly confessional artist, whose clear intention was to give utterance to intimate personal feelings. ", "From her earliest works she favoured smaller, more delicate combinations of instruments, and deployed a distinctive and at that time unfashionable musical language centred on the subtle manipulation of an emotionally expressive melodic line, often supported on a delicate web of post-romantic harmony. ", "She showed no interest at all in the noisily conventional rhetoric so character-istic of most of the Soviet music being written and played around her.", "\n\nFirsova was born in Leningrad on 21 March 1950. ", "Her parents were both physicists, and she grew up in an atmosphere where education was taken seriously. ", "When she was still quite young, her family moved to Moscow, and there she received her musical training, entering music college in 1966 and the Moscow Conservatoire in 1970. ", "During five years at the Conservatoire, she studied composition with Alexander Pirumov and analysis with the distinguished Yuri Kholopov. ", "But it was her unofficial contacts during her student years that she regards as having had a crucial influence on her later development. ", "The most important of these were with the composer Edison Denisov and the teacher and Webern-pupil, Philip Gershkovich (Hershkovitz). ", "It was at this time too that she met her husband, the composer Dmitri Smirnov.", "\n\nIn 1970, when she was still at music college, she wrote her first settings of Osip Mandelstam, who died in the Stalinist camps in 1938. ", "Though now regarded as one of the greatest Russian poets of the 20th century, Mandelstam was unpublished in the Soviet Union in the period when Firsova first fell in love with his work, and was to remain so until Glasnost in the late 1980s. ", "Her contact with the luminous world of this writer’s imagination could come only through carefully hidden and preserved old editions or through unofficial samizdat publications. ", "Firsova has written more than a dozen settings of Mandelstam’s verse and a series of instrumental compositions inspired by his words. ", "She has said that \"Had I been a poet, his is the poetry I would like to have written\". ", "For a composer who dislikes talking about music, the Mandelstam texts she has chosen come closest to describing the inner nature of Firsova’s art. ", "Particularly suggestive are lines set in one of her most appealing and characteristic pieces, the chamber cantata Earthly Life of 1984.", "\n\nWhat have you to do with me,Earthly life and beauty,When that has reminded meWho I am and who my dream...\n\nOn the glass of eternity has already lainMy breath, my warmth...Let the moment’s lees trickle down - Don’t wipe away the sweet design...\n\nUp out of an evil festering poolI sprang, whispering like a reed,Passionately, secretly, tenderlyBreathing the forbidden life...\n\nAlthough Elena Firsova never sought political conflict, it was in the nature of the society to which she belonged that such conflict inevitably materialised. ", "The music she wrote placed her from the beginning among the ‘unofficial’ Soviet composers (of whom the most well-known were Denisov, Schnittke and Gubaidulina). ", "This led in 1979 to her being included with her husband in the ‘Seven’ who were publicly castigated by the notorious head of the Composers’ Union, Tikhon Khrennikov, for having allowed their music (which he described as ‘not representative of the work of Soviet composers’) to be played in a festival in Cologne. ", "This rebuke had no effect on Firsova’s confidence, but it markedly increased Western interest in her music, which was certainly not the effect Khrennikov had intended.", "\n\nUnsurprisingly, and more recently, the collapse of Soviet power in the late 1980s and the troubled conditions of the new Russia have had a considerable effect on Elena Firsova’s life and music. ", "The rate of her musical output acquired a new urgency, with no less than 29 pieces written between 1991 and 1993, and its range broadened as if through poetic necessity with her attention turning to the composition of music on a larger scale. ", "Between 1988 and 1992 she completed four pieces for full orchestra which, taken together as a cycle, make up what is perhaps her most important creative statement to date.", "\n\nThe first of these orchestral works, Augury, composed in 1988 and premiered at the 1992 BBC Proms in London by the BBC Symphony Orchestra under Andrew Davis, culminates in a choral setting of Blake’s famous lines beginning ‘To see the world in a grain of sand...’ Although the text is by Blake, Augury seems to sum up many of the characteristic preoccupations and moods of Firsova’s settings of Mandelstam; the music rises and falls on the waves of a romantic and lyrical reaching after ecstasy. ", "The composition of Augury was followed in 1989 by Nostalgia, where both title and music seem to reflect the composer’s growing anxiety about the future and the increasing pressure to consider a period spent outside Russia. ", "In 1991 the decisive break was made: Elena Firsova and her husband and children moved to Britain where they made brief stays at Cambridge University and Dartington Hall in Devon, before being appointed as joint composers-in-residence at Keele University.", "\n\nEarly in 1992, Firsova completed one of her most ambitious works, an uncommissioned setting for soprano and full orchestra of poems by her beloved Mandelstam entitled Secret Way, commissioned by WDR and premiered by the Moscow Radio Orchestra under Vladimir Fedoseyev at the Musikverein in Vienna in 1996. ", "The human voice, as in Augury, here fulfils a summarising role towards the end of the work, singing a text which explores a bleak and broken world in which verbal memory is lost amidst the tolling of Stygian bells. ", "The fourth and last of this cycle of recent orchestral works is Cassandra, commissioned, premiered and recorded by the BBC National Orchestra of Wales under Tadaaki Otaka. ", "It is named after the prophetess of impending doom who, for Firsova, spoke not only of Troy but also of contemporary Russia.", "\n\nDespite her newfound commitment to orchestral music, Firsova has continued to produce a large body of chamber music, both for purely instrumental forces as seen in her ongoing series of string quartets, and for the idiomatic combination of solo voice and chamber ensemble which has been so central to Firsova’s output. ", "In 1992 she composed Distance for the Birmingham Contemporary Music Group, a setting of poems by Marina Tsvetayeva which depicts the same loneliness and desperation as the contemporary Secret Way. ", "Firsova’s 1994 chamber cantata Before the Thunderstorm returns to Mandelstam and is an impressive successor to Earthly Life and Forest Walks. ", "All three chamber cantatas were given their premiere by the Nash Ensemble who, together with the BBC, have been the most stalwart of champions for her music. ", "New departures for Firsova in recent years have included a chamber opera, The Nightingale and the Rose, premiered at the 1994 Almeida Opera Festival, and an a cappella setting of Pushkin for WDR and The Hilliard Ensemble, entitled Insomnia.", "\n\nThrough all the various changes that have taken place over the last decade, both in her outside life and in the inner life of her music, Elena Firsova has clung tenaciously to her distinctive musical voice and to her fiercely held musical ideals. ", "In each new piece we can be sure to hear the characteristic qualities that emerged so early in her career, the same singing line and supple harmonies, and the same sense that this is an artist telling us about what she herself has felt, about what she would have us feel too." ]

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[ "Andrew Bynum: ‘I’m Looking at Three Weeks’\n\nDave McMenamin has an update on L.A.’s sidelined big: “In Los Angeles Lakers center Andrew Bynum‘s first full-contact on-court workout Saturday, he leaned on an old friend — literally. ", "Bynum participated in half-court drills and banged bodies with Lakers backup center Derrick Caracter, who despite being a rookie is only six months younger than the sixth-year veteran. ", "The two played prep basketball against each another in their home state of New Jersey. ", "Now Bynum is prepping to make his return from offseason surgery on his right knee and his rehab is in the home stretch. ‘", "I want to [return] midway through December,’ Bynum said. ‘", "Hopefully, that’s two weeks. ", "It’s looking more like a little bit later, probably. ", "I have these two weeks here, then a week of practice. ", "Realistically I’m looking at three weeks.’" ]

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[ "A yob who killed a bus passenger during a row about his swearing has been jailed for just 27 months. ", "Gary Robson, 23, shoved 60-year-old Stanley Dixon off the bus after he challenged him about his language. ", "Mr Dixon hit his head on a pavement and died in hospital four days later. ", "The drunken thug lunged at Mr Dixon after his partner, Anne Fisher, challenged Robson over the way he was speaking to his own girlfriend. ", "Her complaints were met with a barrage of insults and abuse, prompting Mr Dixon to stick up for her. ", "Newcastle Crown Court heard Mr Dixon and Mrs Fisher had been travelling home to Peterlee from a night out in Hartlepool when Robson and his pals got onto the same bus. ", "Prosecutor Ewan Duff said: 'Anne Fisher had remonstrated with the defendant for using foul language and being abusive on a public service bus late in the evening. '", "The remonstration by Mrs Fisher led to the defendant then being abusive to her and in turn led to Mr Dixon intervening in an attempt to stop that abuse. '", "The incident ended with the defendant pushing Mr Dixon from the bus on which they all had been travelling so that he fell back from the bus, struck his head on the pavement and from which he sustained fatal injuries from which he died.' ", "Fellow passengers had also been insulted and forced to change seats to get away from Robson and his friends during the journey. ", "One elderly lady had said Robson in particular was using foul language. '", "Every other word he used was the \"F\" word, it was upsetting to all,' she told police. ", "The court heard it was when Robson, who was celebrating landing a new sales job, had turned his anger and aggression towards his own girlfriend, that Mrs Fisher decided to speak out. '", "It seems to have been the abuse from the defendant towards his own girlfriend that caused Mrs Fisher to intevene,' Mr Duff said. '", "What she did was to turn and ask the defendant to stop swearing as there were young girls on the bus. '", "The response of the defendant when Mrs Fisher asked them to stop was to say something to her like \"what the f**** has it got to do with you\" or \"shut the f*** up and mind your own business\".' ", "The court heard it was at this point Mr Dixon, a divorced father-of-three with a history of heart trouble, stepped in to defend his partner, but was also met with abuse. ", "Mr Duff added: 'The general picture is of the defendant being aggressive towards Mr DIxon and indeed attempting to hit him on a number of occasions.' ", "Even Robson's girlfriend and his friend were trying to pull him back from Mr Dixon and Mrs Fisher, who had already decided to leave the bus. ", "It was as they stopped to give the driver, who was calling the police, their names and addresses that the fatal clash occurred. ", "Mr Duff said: 'Mrs Fisher saw the defendant coming from the back of the bus and she feared he was going to attack Mr Dixon so she attempted to bar his way. '", "She was struck in the face by the defendant, her glasses were knocked sideways and the defendant was able to get past her. '", "Mr Dixon was posing no threat at all to the defendant and the defendant made a very determined effort to get to him, knocking Mrs Fisher aside, forcing his way past her and quite deliberately pushing Mr Dixon forcefully in the chest.' ", "Mr Dixon was taken to Sunderland Royal Hospital and later transfered to a specialist at Newcastle General but was pronounced dead on July 2. ", "The court heard Mr Dixon, who divorced the mother of his three children in 1999, had met Mrs Fisher, who has one daughter, in 2002. ", "After the attack Robson went home and bought himself a pizza before being arrested by police the next day. ", "Defence barrister Richard Bloomfield said Robson, who had previously been in the armed forces, was genuinely sorry for what he did. ", "Mr Bloomfield said; 'He will always have to carry with him the knowledge he was responsible for the responsible for the death of another person, all be it unintended. '", "He carries that with him and does appear to be genuinely remorseful for what he has done.' ", "Judge David Hodson jailed Robson for 27 months. ", "The judge said: 'It is well recognised that these cases are among the most difficult that any court has to deal with. '", "Mrs Fisher's victim impact statement speaks of the devastation that Mr Dixon's death has caused her and how her life will never be the same again. '", "No court can ever restore Stanley Dixon to his family, no sentence can ever match their dreadful loss, no sentence of the defendant can ever equate to the sentence the family will have to endure, that will last forever. '", "The court must have in mind the unlawful act was done without any intention to kill or cause really serious harm. '", "Of course the result was Mr Dixon's death, but I accept that was not your intention.' ", "Robson, of Peterlee, County Durham, admitted manslaugher at an earlier hearing." ]

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[ "# Building the Azure Kinect ROS Driver\n\n## Pre-requisites\n\nBefore trying to build the Azure Kinect ROS Driver, you will need to install two required dependencies:\n\n- ROS Melodic (Ubuntu or Windows 10)\n- Azure Kinect Sensor SDK\n\n### ROS\n\nFollow the [installation instructions](https://wiki.ros.org/Installation) for your operating system of choice: [Ubuntu](https://wiki.ros.org/Installation/Ubuntu), or [Windows](https://wiki.ros.org/Installation/Windows) to install ROS. ", "Verify that ROS is working and that you can build sample projects in your catkin workspace before trying to build the Azure Kinect ROS Driver.", "\n\n### Azure Kinect Sensor SDK\n\nFollow the [installation instructions](https://github.com/microsoft/Azure-Kinect-Sensor-SDK/blob/develop/docs/usage.md#Installation) in the Azure Kinect Sensor SDK repo to install the sensor SDK for your platform.", "\n\nThe Azure Kinect ROS Driver includes CMake files which will try to locate the Azure Kinect Sensor SDK. ", "Installing the SDK in a non-default location will result in compile failures when CMake is unable to locate the SDK.", "\n\nThe Azure Kinect ROS Driver requires version of v1.1.0 of the Azure Kinect Sensor SDK to compile.", "\n\n#### Alternate SDK Installation\n\nInstead of installing the Azure Kinect Sensor SDK to the system path (using the `.msi` installer on Windows or the `.deb` installer on Ubuntu) you can extract the SDK the `.\\ext\\sdk` folder. ", "You should have the following folder structure after extracting the SDK into `.\\ext\\sdk`:\n\n```\n.\\ext\\sdk\\\n bin\\\n include\\\n lib\\\n```\n\nPlease note that the Azure Kinect Sensor SDK zip files do not contain the depth engine shared library. ", "You will need to acquire a version of the depth engine shared library and place it in the .\\ext\\sdk\\bin folder so that it can be consumed by the build system. ", "Failing to download the depth engine when using an extracted SDK will result in the node crashing on launch.", "\n\nFor more information, please consult the [Azure Kinect Sensor SDK usage guide](https://github.com/microsoft/Azure-Kinect-Sensor-SDK/blob/develop/docs/usage.md).", "\n\n## Compiling\n\nOnce the Azure Kinect Sensor SDK has been installed, the ROS node can be built using `catkin_make`. ", "Please note that you may need to run `catkin_make --force-cmake` to update the SDK binaries which are copied into the ROS output folders.", "\n\n" ]

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[ "Q:\n\nWhy 10.333333 | 0 = 10 in JavaScript?", "\n\nI'm wondering how JavaScript evaluates the following expression:\n10.333333 | 0 === 10\nIs it because of bitwise ORing ignores the decimal part?", "\n\nA:\n\nJavaScript bitwise operators all work by converting their operands to 32-bit integers. ", "The operation is performed and the result is converted back to a (floating point) number.", "\n\n" ]

{ "pile_set_name": "StackExchange" }

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[ "// Copyright 2012 The Go Authors. ", "All rights reserved.", "\n// Use of this source code is governed by a BSD-style\n// license that can be found in the LICENSE file.", "\n\npackage ipv4\n\n// TOS returns the type-of-service field value for outgoing packets.", "\nfunc (c *genericOpt) TOS() (int, error) {\n\tif !", "c.ok() {\n\t\treturn 0, errInvalidConn\n\t}\n\tso, ok := sockOpts[ssoTOS]\n\tif !", "ok {\n\t\treturn 0, errNotImplemented\n\t}\n\treturn so.", "GetInt(c.", "Conn)\n}\n\n// SetTOS sets the type-of-service field value for future outgoing\n// packets.", "\nfunc (c *genericOpt) SetTOS(tos int) error {\n\tif !", "c.ok() {\n\t\treturn errInvalidConn\n\t}\n\tso, ok := sockOpts[ssoTOS]\n\tif !", "ok {\n\t\treturn errNotImplemented\n\t}\n\treturn so.", "SetInt(c.", "Conn, tos)\n}\n\n// TTL returns the time-to-live field value for outgoing packets.", "\nfunc (c *genericOpt) TTL() (int, error) {\n\tif !", "c.ok() {\n\t\treturn 0, errInvalidConn\n\t}\n\tso, ok := sockOpts[ssoTTL]\n\tif !", "ok {\n\t\treturn 0, errNotImplemented\n\t}\n\treturn so.", "GetInt(c.", "Conn)\n}\n\n// SetTTL sets the time-to-live field value for future outgoing\n// packets.", "\nfunc (c *genericOpt) SetTTL(ttl int) error {\n\tif !", "c.ok() {\n\t\treturn errInvalidConn\n\t}\n\tso, ok := sockOpts[ssoTTL]\n\tif !", "ok {\n\t\treturn errNotImplemented\n\t}\n\treturn so.", "SetInt(c.", "Conn, ttl)\n}\n" ]

{ "pile_set_name": "Github" }

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[ "Comparison of Patient-Reported Outcome Measurements and Objective Measurements after Cubital Tunnel Decompression.", "\nThe aims of this study were (1) to compare the responsiveness of disease and hand-related issues, including health status-related questions, in patients with cubital tunnel syndrome; and (2) to assess whether these tools and objective hand tests are associated with the results of nerve conduction studies after a simple cubital tunnel syndrome decompression. ", "Forty-seven patients with diagnosed condition were enrolled in the study. ", "The following tools were used preoperatively and again at 3 and 6 months: the Patient-Rated Ulnar Nerve Evaluation; the Michigan Hand Outcomes Questionnaire; the Disabilities of the Arm, Shoulder, and Hand; the 12-Item Short-Form Health Survey; the pain visual analogue scale with activity; the grip and key pinch test, two-point discrimination, and the ulnar nerve conduction studies test. ", "All questionnaires and pain visual analogue scale, two-point discrimination, and nerve conduction studies improved significantly at the 6-month follow-up (p < 0.05) compared with preoperative outcomes. ", "Correlations were observed between preoperative motor conduction velocity, preoperative work of the Michigan Hand Outcomes Questionnaire (R = -0.38; p = 0.049), and pain visual analogue scale during activity (R = 0.47; p = 0.025). ", "A correlation was found between motor conduction velocity change after 6 months and the hand function of the Michigan Hand Outcomes Questionnaire after 6 months (R = 0.57; p = 0.017). ", "The Patient-Rated Ulnar Nerve Evaluation and the Michigan Hand Outcomes Questionnaire were more responsive for short-term recovery compared with other measures; however, only the latter correlated with motor conduction velocity." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "Q:\n\nHow do I use all() built-in function?", "\n\nI am attempting to use all() but it is not working for me:\n>>> names = [\"Rhonda\", \"Ryan\", \"Red Rackham\", \"Paul\"]\n>>> all([name for name in names if name[0] == \"R\"])\nTrue\n>>> \n\nI am trying to check if all the names begin with \"R\", and even though I added \"Paul\" to names, all() still returns True. ", "How do I fix this so that all() returns False until \"Paul\" is removed?", "\n\nA:\n\nYou misunderstand how all works. ", " From the docs:\n\nall(iterable)\nReturn True if all elements of the iterable are true (or if the\n iterable is empty).", "\n\nIn your code, you are first collecting all names that start with R into a list and then passing this list to all. ", " Doing this will always return True because non-empty strings evaluate to True.", "\n\nInstead, you should write:\nall(name[0] == \"R\" for name in names)\n\nThis will pass an iterable of booleans to all. ", " If all of them are True, the function will return True; otherwise, it will return False.", "\nAs an added bonus, the result will now be computed lazily because we used a generator expression instead of a list comprehension. ", " With the list comprehension, the code needed to test all strings before determining a result. ", " The new code however will only check as many as necessary. ", "\n\n" ]

{ "pile_set_name": "StackExchange" }

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[ "1. ", "Field of the Invention\nThe present invention relates to a lithographic apparatus, beam delivery systems, prisms and to device manufacturing methods.", "\n2. ", "Description of the Related Art\nA lithographic apparatus is a machine that applies a desired pattern onto a substrate, usually onto a target portion of the substrate. ", "A lithographic apparatus can be used, for example, in the manufacture of integrated circuits (ICs). ", "In that instance, a patterning device, which is alternatively referred to as a mask or a reticle, may be used to generate a circuit pattern to be formed on an individual layer of the IC. ", "This pattern can be transferred onto a target portion (e.g. comprising part of, one, or several dies) on a substrate (e.g. a silicon wafer). ", "Transfer of the pattern is typically via imaging onto a layer of radiation-sensitive material (resist) provided on the substrate. ", "In general, a single substrate will contain a network of adjacent target portions that are successively patterned. ", "Known lithographic apparatus include steppers, in which each target portion is irradiated by exposing an entire pattern onto the target portion at one time, and scanners, in which each target portion is irradiated by scanning the pattern through a radiation beam in a given direction (the “scanning” direction) while synchronously scanning the substrate parallel or anti-parallel to this direction. ", "It is also possible to transfer the pattern from the patterning device to the substrate by imprinting the pattern onto the substrate.", "\nA lithographic apparatus requires a high-intensity, narrowband light source. ", "Early lithographic apparatus used high-pressure mercury vapor lamps and filters to select a single emission line. ", "However, the drive to fabricate components with ever smaller feature sizes has necessitated the use of shorter wavelengths. ", "Thus excimer lasers, e.g. with outputs at 248, 193 or 157 nm, are now commonly used. ", "Such a laser is a large device with a high power consumption so is commonly located outside of the clean room containing the lithographic apparatus with the laser beam being “piped” to the lithographic apparatus by a beam delivery system. ", "This is possible because the laser beam is well collimated and has a small cross-section. ", "A beam delivery system may involve multiple, for example, at least two and typically 3 to 6, reflections of the beam by high-reflectivity mirrors oriented at 45° to the beam axis.", "\nRecently, improvements of the resolution of lithography apparatus have been made by control of the polarization of the exposure radiation. ", "Although the output of an excimer laser has a high degree of polarization, this is often reduced by the beam delivery system, which may involve multiple mirrors in the p-mode, so that a clean-up polarizer must be provided in the illumination system of the lithographic apparatus to achieve a desired high degree of polarization, e.g. >93%. ", "The clean-up polarizer unavoidably reduces the intensity of the beam of radiation, reducing throughput." ]

{ "pile_set_name": "USPTO Backgrounds" }

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[ "Posterior Fusion in Patients with Trauma, Instability, and Tumor of the Cervical Spine.", "\nTrauma, instabilities and tumors of the cervical spine are treated with established methods of surgery. ", "Therefore, anterior fusion is considered to be a standardized procedure for the lower cervical spine, while posterior and anterior instrumentation facilitates stabilization of the upper cervical spine. ", "However, special situations that particularly require posterior instrumentation in traumatic lesions, tumor or other kinds of instabilities arise again and again. ", "Neurological deficit symptoms, bone quality and related diseases fundamentally lead to a decision of posterior access and fusion. ", "Different pathologies and corresponding reasons for posterior surgical interventions on the cervical spine are described in this paper and discussed using the current literature." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "[Antigenic changes of Tau protein induced by glutamate on primary cultures of neurons: immunocytochemistry study].", "\nDegenerating neurons in Alzheimer's disease are characterized by the presence of neurofibrillary tangles constituted by paired helical filaments (PHF). ", "Abnormally phosphorylated Tau protein, a microtubule associated protein is one of the major component of PHF. ", "Abnormal phosphorylation seems to be located in the C-terminal domain but also in the N-terminal region of Tau proteins. ", "Previous studies demonstrated that calcium-mediated glutamate toxicity produces a dose-dependent increase of Tau immunolabellings in neuronal cultures. ", "Biochemical results revealed that these changes could be associated with abnormal Tau migrations on immunoblots. ", "Using three anti-Tau antibodies the present study shows that glutamate toxicity induces in neuronal cultures, Tau modifications localized in the N- and C-terminal domains of the protein. ", "These findings suggest the possibility that glutamate toxicity can induce Tau antigenic changes involving probably the whole molecule." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "Integrate full Kodi movie information in your system with The Movie Database add-on! ", "This is a must have for everyone and adds some great polish to your Kodi skin interface.", "\n\nDo you want Kodi movie information, plot, cast, trailer, rating, and information for every single movie in your favourite add-ons like Genesis, 1channel, and Primewire? ", "The Movie Database is a great add-on that you can install and forget about how awesome it makes your Kodi experience.", "\n\nFirst, lets see how to install The Movie Database add-on:\n\nSettings\n\nAdd-ons\n\nGet add-ons\n\nKodi/XBMC add-on repository\n\nMovie information\n\nThe Movie Database\n\nInstall\n\nOnce installed, The Movie Database works behind the scenes to automatically populate information about movies and TV shows wherever you are in your Kodi menus. ", "I use the SilenceROM hybrid skin found in the SilenceROM community build and it’s nice to have information whenever I go check out a movie or TV show in Genesis.", "\n\nIf you click ‘c’ to bring up the context menu on a movie, you can click on “Movie Information” and The Movie Database automatically generates a ton of great info:\n\nCast\n\nMovie poster\n\nSummary of the plot\n\nRating\n\nTrailer\n\nThe trailer is a really nice feature. ", "If you are looking for a movie to watch in Genesis, bring up the “Movie Information” menu, click on trailer, and Kodi and The Movie Database will automatically download the trailer off of youtube and begin playing it for you!", "\n\nThe best part about The Movie Database is that it works without any interference from you. ", "It integrates well into Kodi and the SilenceROM skin specifically so that you can see dynamic movie posters, screenshots, and information about whatever movie you are hovering on in real time.", "\n\nFollow KodiTips on Facebook and Twitter and let us know what you think about The Movie Database!" ]

{ "pile_set_name": "OpenWebText2" }

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[ "Herbicidal treatments for control of Papaver somniferum L.\nFifty-five commercially available herbicides were evaluated for possible use to destroy illicit opium poppy crops (Papaver somniferum). ", "In the first stage, herbicides were sprayed on poppy plants grown in containers. ", "The following compounds killed poppy plants: (a) herbicides with typical foliar activity--amitrole, bromoxynil, 2,4-D, glyphosate, ioxynil and paraquat; and (b) herbicides with root and foliar activity--the triazines ametryn, atrazine, metribuzin, prometryn, simazine and terbutryn; the substituted ureas benzthiazuron, chloroxuron, diuron, fluometuron, linuron, methabenzthiazuron, neburon and phenobenzuron; and the miscellaneous compounds karbutilate, methazole, oxadiazon and pyrazon. ", "Severe but sublethal injury was caused by cycloate, EPTC, molinate, pobulate, cacodylate + MSMA, ethofumesate, perfluidone and phenmedipham. ", "Abnormal development of vegetative or reproductive parts of the plant was induced by benefin, butralin, dinitramine, pendimethalin, trifluralin, diphenamid, napropamide, dalapon and propham. ", "Efficient herbicides with negligible persistence in soil at the doses applied were evaluated on poppy plants in the field at various stages of growth. ", "Small plants were severely injured by 2,4-D, killed rapidly by bromoxynil, ioxynil, paraquat (in mixture + diquat), and more slowly by glyphosate and metribuzin. ", "The resistance to herbicides increased with the age of the poppy plant. ", "Severe damage with partial kill of developed plants was obtained with bromoxynil, ioxynil, glyphosate, and paraquat + diquat; the last treatment produced the fastest effect." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "Barman\n\nYou will be responsible to assist with the efficient running of the department in line with Hyatt International's Corporate Strategies and brand standards, whilst meeting employee, guest and owner expectations.", "\n\nThe Barman is responsible to assist the team in managing the Bar as a successful independent profit centre, in line with the outlet’s operating concept and Hyatt International standards, ensuring maximum guest satisfaction.", "\n\nYou will be in charge of the service in the Bar as well as the customer relationship.", "\n\nRequirements\n\nIdeally with a relevant degree, apprenticeship or diploma in Hospitality or restaurant management.", "\n\nYou have the following assets:\n\n- Sense of service\n\n- English spoken fluently\n\n- Reactivity and flexilibity\n\nJob Info\n\nFrance, France\n\nHyatt Hotels Corporation\n\nPosted on: 11/21/2016\n\nBonus Plan:\nNo\n\nWork Permit:\nApplicants who do not already have legal permission to work in the location of this job will not be considered.", "\n\nAccommodations:\nNo\n\nManagement Position:\nNo\n\nDescription\n\nYou will be responsible to assist with the efficient running of the department in line with Hyatt International's Corporate Strategies and brand standards, whilst meeting employee, guest and owner expectations.", "\n\nThe Barman is responsible to assist the team in managing the Bar as a successful independent profit centre, in line with the outlet’s operating concept and Hyatt International standards, ensuring maximum guest satisfaction.", "\n\nYou will be in charge of the service in the Bar as well as the customer relationship.", "\n\nRequirements\n\nIdeally with a relevant degree, apprenticeship or diploma in Hospitality or restaurant management." ]

{ "pile_set_name": "Pile-CC" }

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[ "Budget Priorities\n\nFY 2016 BUDGET PRIORITIES\n\nEach February the President is expected to release a proposed budget outlining the Administration’s funding priorities for each federal agency. ", "Thurgood Marshall College Fund (TMCF) reviews the budget and advocates for our own distinct proposed funding levels for our priority federal programs. ", "As the budget and appropriations process unfolds, TMCF meets with key Congressional members and staff to brief them on key policy recommendations and gain their support for our suggested funding levels. ", "We often submit stakeholder witness testimony to the Appropriations committee and sometimes even testify before Congress about policy recommendations. ", "As funding for programs across the federal government shrinks, TMCF continues to engage Congress on budget priorities important to HBCUs. ", "We urge Congress to increase, restore or maintain funding for a variety of programs including financial aid, STEM research, faculty development and specific HBCU accounts. ", "As our nation becomes more diverse, HBCUs continue to educate and prepare the next generation of globally diverse leaders in science and technology, medicine, education, law, and public service. ", "We encourage Congress to invest in HBCUs and the students they serve.", "\n\nThe following programs are vital to HBCUs and their mission to educate African Americans and offer rigorous academic programs that prepare students to be globally competitive in corporate, government, academic and research sectors.", "\n\nTitle III Part B: Strengthening Historically Black Colleges and Universities\n\nFunding levels for the Title III, Part B programs are critical to enhance and sustain the quality of HBCUs, and to address national challenges associated with global competitiveness, job creation and changing demographics. ", "Title III Part B programs help HBCUs support undergraduate programs and activities. ", "Under the FY 2016 budget, we are working to protect the existing $267 discretionary funding and $85 million mandatory funding for Title III, Part B programs.", "\n\nDoD HBCU/MI program\n\nTMCF urges Congress to consider an increase of $40 million in the FY 16 budget, or at a minimum maintain the current $34.4 million for the DoD/HBCU MI program. ", "The HBCU/MI program provides access to scientific and technical information products and services to faculty, staff and students of Historically Black Colleges and Universities, American Indian Tribal Colleges and Universities, Native American-Serving Nontribal Institutions, and other minority serving institutions. ", "Click here to learn more about the DoD/HBCU/MI program budget history and TMCF’s FY 2016 funding request.", "\n\nThe HBCU Capital Financing Program\n\nTMCF recommends Congress appropriate $25 million for the HBCU Capital Financing Program in the FY 2016 budget. ", "The HBCU Capital Financing Program supports the construction, reconstruction, and renovation of academic facilities at institutions of higher education. ", "Visit the Department of Education to learn more about the HBCU Capital Financing Program.", "\n\nHBCU Historic Preservation Fund\n\nThe HBCU Historic Preservation Fund was established to identify, and restore those historic structures on HBCU campuses considered to be most historically significant and physically threatened. ", "The fund was also established in direct response to the needs of many historically black colleges and universities, which faced critical rehabilitation needs, but lacked the resources to repair these buildings.", "\n\nTMCF recommends Congress restore funding to the HBCU Historic Preservation Fund at $15 million in the FY 2016 budget. ", "The HBCU Historic Preservation Fund account was last funded in 2009 as part of the American Recovery and Reinvestment Act (ARRA) at the level of $15 million. ", "The Administration has proposed $90 million for the Historic Preservation Fund (HFP). ", "Under this fund, $50 million is being proposed for a Civil Rights initiative to preserve historic projects nationwide that are connected to the Civil Rights and the African American experience. ", "However, the HBCU Historic Preservation Fund is group under the same account at a mere $2.5 million in the proposed FY 2016 budget.", "\n\n1890 Education and Facility Programs (HBCU Land-grant Universities)\n\nSupport for the 1890 Education and Facility Programs. ", "There are four programs under this account. ", "The funds are used to strengthen research, extension and teaching in the food and agricultural sciences by building the institutional capacities of the 1890 Institutions, including Tuskegee University.", "\n\nSTEM Education Programs\n\nInvestment in STEM education across the federal government is a national security issue. ", "Please see below targeted programs that increase minority participation in STEM education and careers. ", "We request that Congress fund these programs in the FY 2016 budget.", "\n\nRelated Documents\n\nThurgood Marshall College Fund is the nation’s largest organization exclusively representing the Black College Community. ", "Through scholarships, capacity building and research initiatives, innovative programs and strategic partnerships, TMCF is a vital resource in the PK-12 and higher education space. ", "The organization is also the source of top employers seeking top talent for competitive internships and good jobs. ", "TMCF is a 501(c)(3) tax-exempt, charitable organization." ]

{ "pile_set_name": "Pile-CC" }

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[ "Product Highlights\n\nThe RIO High Efficiency Ductless Mini-Split Heat Pump system is compact, quiet and provides unmatched comfort in any room. ", "The RIO outdoor compressor section is powered by a twin rotary compressor with GREE's DC Inverter technology. ", "This inverter technology with eco-friendly R-410A refrigerant to saves you energy, reduces outdoor noise and keeps room temperature steady by eliminating the constant starts and stops of conventional air conditioning systems. ", "The RIO indoor section is designed to be a comfortable fit in virtually any living space." ]

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[ "Q:\n\nCordova copy www folder to existing build\n\nIf we have only changed assets in the www/ folder of our cordova project, and have not altered any of the native code/plugins, shouldn't it be possible to have a script that just replaces the new www/ folder with the existing one in the ios build output?", "\nThat way we don't have to re-build the entire ios project using cordova build ios every time we want to make a small change and re-run in the simulator. ", "This would save us a nice chunk of time daily.", "\nDoes anything like this exist already?", "\n\nA:\n\nYou have three ways to archive this:\n\nMake absolute symlinks for every file or folder from your root-www-folder to your platform-www-folder. ", "BUT don't symlink the whole www-folder and don't symlink the cordova.js file.", "\nIn Xcode -> Build Phases you can put copy-shell-scripts in Copy www directory for every file or folder of your www-folder. ", "It should look like:\ncp -R /absolute/path/to/your/app/www/index.html /absolute/path/to/your/app/platforms/ios/www/index.html\nYou can use a hook. ", "Put the following hook in hooks->after_platform_add->create_symlinks.js and in hooks->after_build->create_symlinks.js. ", "Everytime you add a android or ios platform or build the application the hook will run.", "\n\nYou have to make the script executable and maybe you need to install shelljs from npm.", "\nHere is my hook, modify it to your needs:\n#!", "/usr/bin/env node\n\nvar what_to_symlink_from_www = [\n \"assets\",\n \"index.html\"\n];\n\n// no need to change below \n\nvar path = require(\"path\"),\n fs = require(\"fs\"),\n shell = require(\"shelljs\"),\n rootdir = process.argv[2],\n added_platform = process.env.", "CORDOVA_PLATFORMS,\n www = rootdir + \"/www/\",\n android_www = rootdir + \"/platforms/android/assets/www/\",\n ios_www = rootdir + \"/platforms/ios/www/\",\n buildnumber_file = rootdir + \"/buildnumber\",\n buildnumber,\n active_platform_www;\n\nshell.echo(\"\\r\\nHook start: Symlinking\");\n\nif (added_platform === \"ios\") {\n active_platform_www = ios_www;\n do_job()\n}\nelse if (added_platform === \"android\") {\n active_platform_www = android_www;\n do_job()\n}\n\nfunction do_job() {\n what_to_symlink_from_www.forEach(function (item) {\n shell.rm(\"-rf\", active_platform_www + item);\n shell.ln(\"-s\", www + item, active_platform_www + item);\n shell.echo(\"symlinked: \" + item + \" to \" + active_platform_www);\n });\n shell.echo(\"Hook end: Symlinking\" + \"\\r\\n\");\n}\n\n" ]

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[ "NASA 2011 STTR Program Phase II Selections\n\nNASA 2011 Small Business Technology Transfer (STTR) Program Phase II proposals have been selected for negotiation and publicly announced on Wednesday, May 1, 2013 at 11:00 am. ", "The press release, list of selections, and selection abstracts can be downloaded from this page. ", "Please click on any of the items below.", "\n\nDebriefings\n\nTo request debriefings on Phase II proposals, offerors should send written requests via email to the NASA SBIR/STTR Program Office at ARC-SBIR-PMO@mail.nasa.gov. ", "Requests must be made within 60 days after the selection announcement. ", "Late requests will not be honored. ", "For questions regarding the debriefing process, please contact the NASA SBIR/STTR Support Office." ]

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[ "Q:\n\nПеренос колонки при изменение ширины экрана. ", "Bootstrap\n\nВсем привет. ", "Есть вот такая часть макета \n<div class=\"row exp\">\n <div class=\"col col-ex d-flex flex-column\">\n\n </div>\n <div class=\"col col-cat\">\n\n </div>\n </div>\n\nНа больших экранах это выглядит, как две колонки расположенные рядом по горизонтали. ", "Пытаюсь сделать так, чтобы при использовании средних экранов первая колонка занимала уже всю ширину родителя, а вторая колонка перенеслась под первую и также заняла всю ширину. ", "Подскажите пожалуйста, как можно это сделать?", "\n\nA:\n\nВместо класса col добавьте классы col-md-6 или col-lg-6 (в зависимости от того, при каком размере экрана Вы хотите получить изменения):\n\n[class^=\"col\"] {\r\n border: 1px solid red;\r\n padding: 50px;\r\n}\n<link rel=\"stylesheet\" href=\"https://stackpath.bootstrapcdn.com/bootstrap/4.4.1/css/bootstrap.min.css\" integrity=\"sha384-Vkoo8x4CGsO3+Hhxv8T/Q5PaXtkKtu6ug5TOeNV6gBiFeWPGFN9MuhOf23Q9Ifjh\" crossorigin=\"anonymous\">\r\n<div class=\"row exp\">\r\n <div class=\"col-md-6 col-ex d-flex flex-column\">\r\n\r\n </div>\r\n <div class=\"col-md-6 col-cat\">\r\n\r\n </div>\r\n</div>\n\n" ]

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[ "Making the electronic medical record work for the orthopedic surgeon.", "\nThis article explores the current reasons why orthopedic surgeons might consider the adoption of an electronic medical record system in their practices today. ", "The costs and benefits as well as the barriers to implementation are discussed." ]

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[ "Pages\n\nMonday, September 9, 2019\n\nA premium crochet pattern\n\nThere is a brand new pattern in the shop. ", "The Ansley Hat is is a crochet version of the knit Wellsley Hat.", "That hat pattern has become my most popular knitting pattern on the blog. ", "I really hope you will love the crochet version just as much.", "\n\nThis pattern has been tech edited and tested. ", "I have to say that my testers were amazing this time around. ", "Every one of them finished the hat and gave great suggestions. ", "They all really enjoyed making the pattern and most of them made more than one.", "\n\nFor the Model I used Red Heart Chic Sheep. ", "I can't tell you how excited I am that Red Heart has come out with a 100% merino wool option. ", "A few of the testers used Lion brand Vanna's Choice yarn, and those came out great too. ", "Any size 4 yarn that has a gauge between 14 and 16 stitches per 4 inches/ 10 cm would be a great option for this hat.", "\n\nFpdc2tog: yo, insert hook around the first post of the stitches indicated, yo, and pull the hook back around, (3 loops on the hook), yo, and pull through 2 loops on the hook, (2 loops on the hook), insert hook around the second post of the stitches indicated, yo, and pull the hook back around, (4 loops on the hook), yo and pull through 2 loops on the hook, yo and pull through the last 3 loops on the hook.", "\n\nCopyright: Julia Schwartz.", "\n\nDo not reproduce, copy, distribute, or sell this pattern without permission of the designer. ", "This pattern must not be translated, reproduced, or circulated in another language without prior consent. ", "If you have questions about this pattern please contact Julia.diligence@gmail.com.", "\n\nWhere Can I Get This Pattern\n\nThis Pattern is for sale in my ravelry shop. ", "This is an ads free printer friendly pattern that has been tech edited and tested. ", "It's a great price of $3.00 (USD) for the quality you will get. ", "Ravelry Shop\n\nEven if you are not ready to buy today. ", "I would love it if you gave this pattern some love on Ravelry!", "\n\nStay Connected!", "\n\nIf you like this pattern and you don't want to miss the next one be sure to subscribe to Designs by Diligence to get notified when new patterns come out. ", "The only time you will get an email is when a new post happens on the blog, usually on Tuesday.", "\n\nPin For Later!", "\n\nMonday, August 19, 2019\n\nA Free Knitting Pattern\n\nI love refreshing patterns, making them into something new with a fresh purpose. ", "Some of you might recognize parts of this pattern from my Wellsley Cowl.", "I changed a few stitches, added a lace border and used cotton yarn. ", "In the end I have a really great table runner. ", "Some times we don't need a new thing, we just need a new perspective. ", "I love how this pattern turned out. ", "It also helps that I love the color yellow. ", "I think this would also look really great in a neutral color or going bold with red.", "\n\nIf you are looking for a crochet table runner this one herehas a very similar look to this one.", "\n\nPurchase the pattern!", "\n\nThis is a free knitting pattern found right here on Designs by Diligence. ", "Just keep scrolling down to read the pattern. ", "If you would like to purchase an ads free, printer friendly PDF you can through my Ravelry Pattern Store for $3.00.", "\n\nStay Connected!", "\n\nIf you like this pattern be sure to subscribe to Designs by Diligence to get notified when new patterns come out. ", "The only time you will get an email is when a new post happens on the blog, usually on Tuesday.", "Subscribe in a reader\nYou can also follow me through my social media sites. ", "I love sharing sneak peeks, wips, and fiber arts news and projects.", "Facebook\n\nRight Twist (RT): Knit 2 together keeping both stitches on the left needle, knit into the first stitch, then pull both stitches onto the right needle, stitch complete.", "\n\nLeft Twist (LT): Knit through the back loop of the 2nd st, keep the stitch on the left needle, knit in the first stitch, then pull both stitches onto the right needle, stitch complete.", "\n\nCopyright\nJulia Schwartz. ", "Do not reproduce, copy, distribute, or sell this pattern without permission of the designer. ", "This pattern must not be translated, reproduced, or circulated in another language without prior consent. ", "If you have questions about this pattern please contact Julia.diligence@gmail.com.", "\n\nMonday, August 5, 2019\n\nA free Crochet Pattern\n\nIt's still pretty hot where I live so I have been using my cotton yarn a lot. ", "I love working with cotton when it is hot. ", "How about you? ", "I have some table decor patterns to share with you. ", "This one and a knit version will be coming soon. ", "I have a really large table. ", "We bought it when we moved through the Home Depot website. ", "They had free shipping so we knew the table would be waiting for us at our new house. ", "We did not realize just how large it was. ", "Just the table top without the legs was 250 lbs! ", "Don't get me wrong once we got it up the stairs we have loved it. ", "With it being so large the tablecloths that I had already didn't fit, so I have been making table scarves and mats to use instead. ", "I wanted something that had texture and lace combined and I'm really pleased. ", "I hope you enjoy the pattern too.", "\n\nSubscribe!", "\n\nIf you like this pattern and you don't want to miss the next one be sure to subscribe to Designs by Diligence to get notified when new patterns come out. ", "The only time you will get an email is when a new post happens on the blog, usually on Tuesday.", "\n\nJulia Schwartz. ", "Do not reproduce, copy, distribute, or sell this pattern without permission of the designer. ", "This pattern must not be translated, reproduced, or circulated in another language without prior consent. ", "If you have questions about this pattern please contact Julia.diligence@gmail.com.", "\n\nPurchase the Pattern\n\nThis is a free pattern. ", "Keep scrolling down to see this pattern. ", "If you would like to purchase a pattern that is ads free and printer friendly for $3.00 you can through my Ravelry Store.", "\n\nRow 3: Ch 1, turn, hdc in the next 4 sts, fpdc around the 7th stitch of row 2, sk 1 st, hdc in the next st, fpdc around the 5th stitch of row 2 (crossing over the last fpdc), sk 1 st, hdc in the next 4 sts, fpdc around the 14th stitch of row 2, sk 1 st, hdc in the next st, fpdc around the 12th stitch of row 2 (crossing over the last fpdc), sk 1 st, hdc in the next 4 sts, fpdc around the 21st stitch of row 2, sk 1 st, hdc in the next st, fpdc around the 16th stitch of row 2 (crossing over the last fpdc), sk 1 st, hdc in the last 4 sts. (", "19 hdc, 6 fpdc)\n\nRow 4: Ch 1, turn, hdc in each stitch. (", "25 hdc)\n\nRow 5: Ch 1, turn, hdc in the next 3 sts, {fpdc around fpdc of previous row, sk 1 st, hdc in the next 3 sts, fpdc around the fpdc of previous row, sk 1 st, hdc in the next 2 sts} repeat {to} 2 xs, hdc in the last st. (", "19 hdc, 6 fpdc)\n\nRow 11: Ch 1, turn, hdc in the next 3 sts, {fpdc around fpdc of previous row, sk 1 st, hdc in the next 3 sts, fpdc around the fpdc of previous row, sk 1 st, hdc in the next 2 sts} repeat {to} 2 xs, hdc in the last st. (", "19 hdc, 6 fpdc)\n\nRepeat rows 5 through 16 4 xs or until you have reached your desired length.", "\n\nFinnish off.", "\n\nEdging:\n\nRound 1: Starting at any corner with right side facing up, ch 6 (1st ch 3 counts as 1st dc), 2 dc in starting st, sk 2 sts, {(dc, ch 3, dc) in next st, continue making (dc, ch 3, dc) evenly spaced across the side (model shown has 24 “v” stitches along the long side, and 6 on the short sides), ( 2 dc, ch 3, 2dc) in the corner space} repeat {to} 2xs, for the last side (dc, ch 3, dc) evenly spaced to the corner, dc in the corner, sl st into the starting dc.", "\n\nAbout Me\n\nI love to create! ", "Most of the time that means crocheting, but l also knit and embroider, really anything that makes me think and use my hands I love to do. ", "I started designing my own crochet patterns in 2009 but I did not start writing them down till about 2011. ", "I had no idea that people would find my ideas interesting. ", "I've recently started adding knitting patterns and embroidery tutorials to the blog also.", "\nMy Family and I live just south of Kansas City. ", "My husband is a preacher at a local church. ", "We have two Daughters that I often refer to as The Puzzle Queen and Sweet Pea.", "\nI'm excited to share with you what I am working on and my thoughts on crafting." ]

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[ "Project Summary/Abstract Obesity rates have reached pandemic levels, and current treatment options generally fail to produce long-term sustainable changes in weight. ", "Obesity is a major risk factor for the metabolic syndrome, as well as heart disease and type 2 diabetes. ", "One additional risk factor for metabolic dysfunction, independent of weight status, is stress eating (defined here by separate, but related non-homeostatic eating behaviors, primarily stress eating, and secondarily binge eating). ", "A second potential risk factor is psychological stress-related hypothalamic-pituitary-adrenal axis activity resulting in excessive cortisol. ", "Excess cortisol can, in turn, contribute to abdominal obesity as well as increases in appetite, energy intake, and stress-induced and binge eating. ", "Hence, stress eating and excessive stress reactivity may be potential mechanisms that underpin obesity for some individuals. ", "As such, they are also potential targets for behavioral interventions. ", "Tailored mindfulness-based interventions can address each of these targets, and therefore may represent one promising pathway through which to improve metabolic health in obesity. ", "Indeed, mindfulness-based interventions can reduce perceived stress, stress reactivity, and stress eating. ", "The purpose of the current proposal is to provide me with training that will allow me to become an independent researcher focused on the design and testing of integrative medicine interventions in the context of obesity treatment. ", "By completing the enclosed training plan and receiving expert mentorship at UCSF, I will gain a deep understanding of how mindfulness treatments impact stress eating and profiles of autonomic and cortisol reactivity by analyzing data from an NCCIH-funded intervention (SHINE), which randomized 194 participants to (1) a diet and exercise arm that incorporated mindfulness meditation, or (2) an active control arm that focused solely on diet and exercise. ", "Completing the proposed series of analyses guided by experts will also provide me the opportunity to develop bio-statistical skills, especially in the context of RCT analytic methods. ", "I predict that those who suffer from greater stress eating and stress reactivity will benefit more if randomized to the mindfulness arm. ", "Clarifying the impacts of mindfulness interventions on basic bio-behavioral mechanisms that underlie cardiometabolic health, such as stress eating and stress reactivity, is an important step in understanding and optimizing mindfulness interventions, and shedding light on for whom mindfulness interventions may be most effective. ", "As my long- term career goal is to develop and disseminate complementary and integrative interventions to improve the health of individuals with obesity and other health-related conditions, the F32 NRSA mechanism through NCCIH will provide me with opportunities to develop as an independent clinical researcher, and develop better evidence-based strategies for promoting health." ]

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[ "Q:\n\nWriting test classes for a custom controller\n\nI'm having trouble writing the tests for the following custom controller. ", "I'm new to SF and I'm simply displaying a list of \"future\" events on a VF page. ", "It does exactly what I need and I would like to post to production BUT I need to write the tests before. ", "Can some one please help. ", "I don't really know what I should test for. ", "Thanks in advance.", "\n== controller ==\npublic with sharing class FutureEvents {\n Transient public List<Event__c> events;\n public List<Event__c> getEvents() {\n if(events == null) {\n events = [SELECT Name, Event_Website__c FROM Event__c WHERE Event_Start_Date__c > TODAY AND Featured_Event__c = TRUE];\n }\n return events;\n }\n}\n\n== VF page ==\n<apex:page showHeader=\"false\" \n sidebar=\"false\"\n controller=\"FutureEvents\"\n doctype=\"html-5.0\"\n standardStylesheets=\"false\"\n>\n<ul>\n <apex:repeat value=\"{!events}\" var=\"event\">\n <li>\n <apex:outputLink value=\"{!event.", "Event_Website__c}\" target=\"_parent\" rendered=\"{!!ISBLANK(event.", "Event_Website__c)}\">{!event.", "Name}</apex:outputLink>\n <apex:outputText value=\"{!event.name}\" rendered=\"{!ISBLANK(event.", "Event_Website__c)}\"></apex:outputText>\n </li>\n </apex:repeat>\n</ul>\n</apex:page>\n\n== Test ==\n@isTest\npublic class FutureEventsTests{\n static testMethod void dtTests() {\n // based on salesforce documentation\n // http://wiki.developerforce.com/page/An_Introduction_to_Apex_Code_Test_Methods\n\n // prepatre data\n List<Event__c> evs = new List<Event__c>{};\n\n for(Integer i = 0; i < 10; i++) {\n Event__c e = new Event__c(Name = 'Event ' + i, \n Featured_Event__c = True);\n evs.add(e);\n }\n\n // Start the test\n test.startTest();\n\n // Insert the Events records\n insert evs;\n\n // Stop the test\n test.stopTest();\n\n List<Event__c> insertedEvents = [SELECT Name FROM Event__c WHERE Featured_Event__c = TRUE];\n\n // Instantiate a new controller\n\n Integer i = 0;\n for (Event__c e : insertedEvents) {\n System.assertEquals('Event ' + i, e.Name);\n System.assert(True, e.Featured_Event__c);\n i++;\n }\n\n } // testMethod\n} // class\n\nA:\n\nTest methods should cover only the subject matter. ", "In this case, the subject matter is the controller.", "\nYour test method should simply make sure it returns events, like this:\nstatic testMethod void test() {\n FutureEvents fe = new FutureEvents();\n Test.startTest();\n Event__c[] events = fe.getEvents();\n Test.stopTest();\n System.assertNotEquals(null, events);\n}\n\nIt doesn't matter what the name of the event is, or how many there are, or anything else, since all you're doing is verifying that it returns a list, and not null.", "\nTesting the events would be a subject matter for a trigger test method, or some other case. ", "All you need to do is verify the controller is functional, and this test proves that.", "\n\n" ]

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[ "Cecil Butcher\n\nCecil Frank Butcher (31 October 1872 – 22 March 1929) was an English cricketer. ", " Butcher was a right-handed batsman who bowled right-arm fast-medium. ", " He was born at Brighton, Sussex.", "\n\nButcher made his first-class debut for Sussex against Kent in 1894 County Championship at the County Ground, Hove. ", " He made five further first-class appearances for Sussex, the last of which came against Lancashire in 1896 County Championship. ", " Smith's role in a team was a bowler, in his six first-class matches for Sussex he took 9 wickets at an average of 39.44, with best figures of 3/107. ", " With the bat, he scored 36 runs at an average of 3.00, with a high score of 13.", "\n\nHe died at Portslade, Sussex, on 22 March 1929.", "\n\nReferences\n\nExternal links\nCecil Butcher at ESPNcricinfo\nCecil Butcher at CricketArchive\n\nCategory:1872 births\nCategory:1929 deaths\nCategory:Sportspeople from Brighton\nCategory:English cricketers\nCategory:Sussex cricketers" ]

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[ "Sunday, April 29, 2012\n\nI will be using a screen that is already made up (from my pottery/clay screening class I took at Pine Tree Potters) (I will be soone showing how to make one of these) and using a glass paint - Reusche Black Trace DE401 mixed with Thompson Screening Medium (Misible with water - which means easy water clean up )\n\nFirst I put together my screen printing assembly - a wood back (got at curry's its a light plywood type box frame but I am using the back ) assembled my screen printing hinges (again curry's or Dick Blick in the States)\nWhen assembled it gives space between the hinge and the screen of approx 3mm - my glass is approx 2mm thick. ", "Once you have the hinges on the back - These hinges allow for you to swap out screens easily\n\nI block off around the image with painters blue tape for easy clean up later and it gives me a space to keep the paint when screening as a rest space. ", "This makes for easy clean up after\n\n(space between the hinge connects top and bottom have the 3mm space which allows for a sheet of glass to sit between without crushing )\n\nWhen I tape the back board - I put a white sheet of paper in the centere so I can see the image after screening\n\nOnce I have it all blocked off I make my paint.", "\n\nUsing Reusche Black Trace DE401 - comes in various sizes - and you do not have to use black - there are lots of colors- and you do not have to use Reusche there are other enamels out there. ", "I'll be using some Thompson enamels shortly\n\nand the A14 Thompson Screening Medium\n\nI mix with a pallet knife till it is sort of like a syrup - not too thin and not too thick - hard to describe - too watery and it will pool on the glass - too thick and you will not get it through the screen. ", "If you make it too thin - it will pool and all you have to do is clean up and start over. - ", "too thick and your images are not clear and may be missing in spots - clean up and start over.", "\n\nI place a clean sheet of glass on the back board - I lower the top and make sure that where the edges meet I have tape over - this just ensures I am not pushing paint where there is no glass. ", "and ensuring I will not tear the screen by pushing on the edge. ", "The tape re-enforces the area. (", "most cut sheet is the same size so you do not have to do this for every sheet of glass. ", "I try to position the white sheet so its within the sheet of glass.", "\n\nOnce mixed I pour a line at the bottom of my screen. ", "Just pour onto the tape - this is what I meant as a resting spot for the paint.", "\n\nI take my squeegee (which needs to be slightly wider than your image) and lightly run it over the screen (not touching the glass ) this is called flooding the screen\n\n(see my hand holding up the screen from the glass)\n\nI put the screen down on top of the glass (and holding it down tight) I push down and draw down the squeegee to the bottom in one motion.", "\n\nHolding the squeegee and the frame- the screen will lift from the glass and then I slowly lift and pull out the glass and put to the side .", "\n\nI hold up the screen frame and flood the screen again. (", "pulling the squeegee to the top) (add more paint if you do not have enough to flood the screen completely. ", "and repeat.", "\n\nBecause its glass paint it may clog and after only a couple of screenings you may have to clean and repeat the process.", "\n\nI only had enough leftover paint to do two screenings. ", "Which I was happy with . ", "This will make me about 35 pieces for my lampwork beads\n\nI sat out to dry - takes quite a while as the screening medium is like an oil - so I set in the sun they will dry - - when wet they are shiny - when dry they are a matte finish to speed up drying I use a hair dryer or a kiln on low - or my electric fryer as its like a huge cup warmer - I want to cut into pieces and fire - or I could get out my big kiln and fire as one big piece and cut later - choices - (if not dry enough before firing it can bubble and pop off )\n\nClean up is easy - just use water .", "\n\nI love my spray hose that screws onto the tap (if you have a tap that you can screw on ) or a hose will do just as well -just not too powerful or you could ruin your screen) it cleans up the screen rather well - just enough pressure to push the paint out\n\nVery happy with the results - clean and crisp\n\nBest part is if you mess up you just wash the glass off and start again\n\nOne of the items I like is to use bead caps from copper. ", "As you see in the finula pins I have been making I like to create with a hole, put a design and cup them.", "\n\nOnce way is to buy the copper circles from Metaliferous in NY another is to get a disc cutter and make your own.", "\n\nNot sure where I got this one but I like it because of the clear acrylic top\n\nIn this pic cutting 18g copper circles\n\nYou would be impressed if I had cut all these but I did not\n\nI got the circles from metaliferous - after I was cutting I remembered I had some in my enamelling supplies so off I went and grabbed them.", "\n\nOne of the tools I bought a long time ago was a hole punch - it has various sizes and does a great job and is easy to use\n\nI put one side of the handle (the bottom) into the vise.", "\n\nIt comes with an adjustable piece that lets you set it so you can repeat the hole. ", "If you work out the center on one of your pieces you can set very easily and makes punching the hole consistent\n\nso you can make a ton of center punched pieces for stamping.", "\n\nI will be attempting to etch so I made up a bunch so that I can either put the pnp blue - but they are so small - but I think I want to try a resist by using a rubber stamp - my zentangle texture mats as another way to transfer the designs\n\nWednesday, April 25, 2012\n\nIn the midst of making some more items using the Hadar Metal Clay -\nI make glass nudes freehand and off rod that are about 4 inches in length and 3d so I decided to take the glass figure and use the two part molding compound to make a mold to use with the clay.", "\nI did a quick mold so its not perfect - but I like less than perfect as the piece I want to make is not going to be symmetrical\n\nwith a silicone mold you can have overcut as when the clay dry's you can easily remove\n\nthe metal clay nudes are not full 3d - they are more hollow at the back\n\nstill needs work but I may just cover it with a toga of mixed patterned clay like my first face\n\nI'll further sand and decide on how I want to use it or just fire it a bronze nude\n\nMonday, April 23, 2012\n\nI am so heartbroken and upset - My cat that I have had for 19 years passed away tonight.", "\nHe had not been well for the past month - the vet thought hyperthyroidism - and we got medication but it really never got him back to health. ", "The last few days more weight loss and finally this morning could hardly walk\ntonight he was beside me until he finally passed.", "\nIts so hard to say goodbye to not only my pet but my friend. ", "He was born on the farm and travelled with me to the U.S. where we stayed for 8 years. . ", "We came back 7 years ago - back to the farm where he was born and where I'll bury him tomorrow .I will truly miss this wonderful feline.", "\n\nSaturday, April 21, 2012\n\nAt the final version and as I make them I make changes as I go - I've taken apart the copper ones (even though I love the copper) to do a mixed version of silver and copper.", "\nPlaying with different gauges of silver wire -\n\nthe step by step is 12g - I found the 12g a bit thick so maybe a 14 would be better - your choice.", "\n\nPick out your wire\n\nI found working from the pin side first makes it easier to tighten the beads on the pin and the curly part at the end is your left over with little waste.", "\nThe pin length will depend on the beads your going to apply so if you have a piece of scrap wire assemble your mix. ", "and add about 1/2\"\n\nTools: Round Nose Pliers, Chain Nose Pliers, Side cutters.", "\n\nNylon tip - less clean up from dents in the wire but you can buff them out\n\nPick out your beads and findings - I had my lampwork beads, some sterling silver plated beads, and plain copper bead caps I made\n\nI measured out my beads on a piece of wire then cut the very tip so it was sharp ( use your side cutters backwards - this time you want a pointy end ) of my 12g wire - dont put beads on yet\n\nwhat your measuring now is where your going to start to wrap your wire around the give yourself about 1/2\" past your beads just to be sure - it can be cut down if too long\n\nIn this case approx 4.25\"\n\nthen I took my round nose pliers and wrapped it round twice\n\nscraggy looking pliers - were orginally dipped in the plastic protection stuff and somewhere along the line I tried using the tips with a too thick of wire and bent them - but their my favorites and I was working towards the back of the pliers. ", "The thicker wire is harder to work with even though it is soft wire\n\nHave not had baby chicks on the farm in a long time\nMy daughter decided she wanted chicks this year at her new house - but she is working this week with me so they are at my house till Friday. ", "They come in a small box so we had to find something to put them in, we had the water container and the feeder and shavings but the heat lamp didn't work - luckily the bathroom is really warm so they survived the night. ", "Day olds - they are so cute\n\nCant get the image of that big yellow chick from HOP out of my head when I see them\n\nWednesday, April 18, 2012\n\nLong ago I took a Connie Fox Class and made a ton of these - Havnt made in a long time so while I was fusing and since I had the pliers out for trying to make the bead pin - I thought I'd start up some bracelets.", "\nI'll need to make some new beads for the sizing but I think I'll make up a bunch for my shows\n\nI use a 10g silver wire to make the base and make my own twisted wire and the beads" ]

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[ "The present invention relates generally to the field of electronic data storage. ", "In particular, the present invention relates to track width definition by patterning of shared poles for an integrated thin film/magnetoresistive head.", "\nThin film magnetic transducing heads are used for magnetically reading information from and writing information to a magnetic storage medium such as a magnetic disc or a magnetic tape. ", "Transducing heads each include a reader portion and a writer portion. ", "The reader portion, which includes a top shield, a bottom shield, and a magnetoresistive (MR) reader positioned between the top and the bottom shields, is used to read magnetically encoded information from the magnetic medium by detecting magnetic flux stored on the magnetic medium. ", "The MR reader (which includes amorphous MR readers, giant MR readers, and spin tunneling readers) generally consists of various magnetic and nonmagnetic layers. ", "The writer portion, which includes a top pole, a bottom pole, conductive coils positioned between the top and bottom poles, and a write gap between the top and bottom poles writes magnetic information to the storage medium. ", "Typically, the top shield of the reader portion and the bottom pole of the writer portion are combined into a common shared pole.", "\nDuring a write operation, the media moves past an air bearing surface of the writer portion of a transducing head, such that a particular portion of the media will first encounter a leading pole of the writer followed by a trailing pole. ", "Magnetic transitions are produced by transducing head only when the applied field falls to media coercivity, i.e., all data is written by the trailing pole. ", "Accordingly, the trailing pole defines the track width of the written data. ", "In disc drive applications, the trailing pole is always the top pole, which is patterned to allow for a more narrow track width. ", "In tape drive applications, in which the magnetic tape media moves bi-directionally, the trailing pole may be either the top pole or the shared pole.", "\nData are stored on magnetic tapes in parallel tracks that extend in the direction of the length of the magnetic tape. ", "Historically, write-wide, read-narrow methodologies were sufficient to ensure that the read heads remained on-track during read-back. ", "With increased data densities on magnetic tapes, new head assemblies were developed that moved across the width of the magnetic tape, such that each read and write head in the head assembly would have access to multiple data tracks. ", "However, write-wide, read-narrow methodologies are no longer sufficient to ensure that these new assemblies remain on track. ", "As a result, dual bump tape heads have been developed to limit tracking errors in these new assemblies.", "\nBi-directional, dual bump tape heads have two transducing heads and are capable of operating in a read while write (RWW) mode. ", "In this RWW mode, a leading transducing head writes information to the tape, while a trailing transducing head reads information from the tape, either data or servo information to ensure that the dual bump tape head remains on track. ", "Each transducing head, or xe2x80x9cbumpxe2x80x9d, includes a writer portion having a top pole, a shared pole, conductive coils positioned between the top pole and the shared pole, and a flex circuit connected to the conductive coils.", "\nThe bumps within a dual bump tape head may be configured in a first configuration with the shared poles of both bumps being centrally located and the top poles of both bumps being peripherally located, such that the shared poles are sandwiched between the top poles (e.g., the reader portions of the two bumps are positioned back-to-back). ", "Conversely, the bumps may be configured in a second configuration with the top poles centrally located and the shared poles peripherally located, such that the top poles are sandwiched between the shared poles (e.g., the writer portions of the two bumps are positioned back-to-back).", "\nIn the first configuration, the shared pole of the leading bump always writes; whereas in the second configuration, the top pole of the leading bump always writes. ", "Accordingly, the second configuration results in a narrower track width than in the first configuration since the patterned top pole is narrower than the shared pole. ", "However, in the second configuration, the flex circuits for the two bumps, which connect to the conductive coils of each bump, are located closer to one another than in the first configuration, resulting in a greater amount of cross-talk between bumps in the second configuration than in the first configuration.", "\nThere is therefore a need for a dual bump tape head which allows for a more narrow track width while minimizes cross-talk between bumps.", "\nA read while write dual bump tape head for increasing allowable linear and areal bit density comprises first and second thin-film inductive write heads. ", "The first thin film, inductive write head has a first top pole and a first shared pole. ", "The first shared pole is patterned such that it has a width at a tape bearing surface of the dual bump tape head narrower than a width of the first top pole at the tape bearing surface. ", "The second thin-film inductive head has a second top pole and a second shared pole. ", "The second shared pole is patterned such that it has a width at the tape bearing surface narrower than a width of the second top pole at the tape bearing surface." ]

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[ "Confluent two-balloon technique: an alternative method for subintimal recanalization of peripheral arterial occlusion.", "\nThe present report describes a technique of simultaneous confluent balloon inflation in cases in which conventional subintimal angioplasty failed. ", "Eight patients with peripheral vascular occlusive disease (n = 4 each with iliac arterial lesions and superficial femoral arterial lesions) of clinical category 3-5 received treatment with the confluent two-balloon technique. ", "Recanalization was successfully completed with this technique in all eight patients, without any major complications. ", "All patients with claudication and rest pain were relieved of their symptoms, and both patients with ulcers showed improvement." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "Twin Traps: Financial Overconfidence During a Time of Cognitive Decline\n\nWe all know that our cognitive abilities tend to decline in our elder years (actually, age 60 on). ", "But did you know we also tend to become overconfident in our financial knowledge and ability to make financial decisions at the same time? ", "Does your retirement plan include steps to deal with this?", "\n\nCourtesy of researchers at the University of Missouri and Texas Tech University:\n\nCOLUMBIA, Mo. – Previous studies have shown that as humans age, cognitive declines are inevitable. ", "Now, a recent study by researchers at the University of Missouri and Texas Tech University has confirmed that this cognitive decline extends into financial literacy. ", "The researchers also found that older individuals retain a strong sense of self-confidence, which could add to the problem, leading to significant mistakes when making financial decisions.", "\n\nMixing a decline of financial literacy with an increase in self-confidence is a toxic combination,” said John Howe, professor and chair of the Department of Finance in the Trulaske College of Business. “", "This opens the door for more honest mistakes as well as fraud. ", "It’s widely known that older adults are very common victims of financial fraud. ", "It’s important that as we age, we find someone who has our best interests in mind when managing our finances.”", "\n\nIn the study, Howe and his colleagues, Michael Finke and Sandra Huston from Texas Tech University, surveyed more than 3,850 individuals 60 and older and found that they experienced increasing declines in financial literacy, which is the ability to understand and make good decisions about personal finances. ", "The researchers also found that the participants’ self-confidence increased slightly. ", "This meant that even though they didn’t understand financial terms or policies well, they still believed they could make good decisions about their personal finances. (", "More on the study here)\n\nBe sure to protect yourself and your loved ones by planning ahead for this potentiality:\n\nConsider a trusted family member or friend who will stand with you and serve as a sounding board for any major financial decisions you make.", "\n\nIf you work with a financial advisor, make sure they are subject to a fiduciary standard, which means they must act in your best interests (not all \"advisors\" are subject to this standard).", "\n\nFinally, be sure you have a valid Durable Power of Attorney (DPOA) that appoints a capable and trusted person to make financial decisions on your behalf should you become unable to do so." ]

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[ "Perseid meteor as seen from the ISS by astronaut Ron Garan on August 13, 2011. ", "Credit: NASA/Ron Garan.", "\n\nWe've featured several timelapse compilations of footage and imagery taken from the International Space Station (like here, here and here) but this one put together by Phil Selmes is great in that it also includes footage *of* the ISS, as shot by the astronauts on the space shuttle as well as actual space to ground audio communications. ", "Phil said he included the audio clips \"to remind the audience of the humanity that inhabits the space station.\"", "\n\nThere is just something about these videos from the ISS that speaks to your soul. ", "Phil told Universe Today that while putting this together, he saw \"how different our world looks just 370kms above our heads. ", "I didn't see politics, races, borders, countries, religions or differences,\" he said via email. \"", "I saw one planet, one world, one incredibly beautiful miracle in the absolute vastness of the universe. ", "It gave me some perspective, ironically it brought me 'back to earth.'\"", "\n\nThe video and imagery is from the Johnson Space Center's Gateway to Astronaut Photography of the Earth.", "\n\nExplore further Ultra-high definition timelapse from the space station" ]

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[ "Intrust Super Cup\n\nFOGS Colts Challenge\n\nFOGS Under 20s Cup\n\nRabbitohs come from behind to\noutsmart Sydney Airport Jets\n\n|\n\nIn a high-scoring match in which a total of fourteen tries were scored, South Sydney defeated Newtown by 45-36 in the VB Premier League fixture played at Aussie Stadium on Saturday.", "\n\nNewtown led by 24-6 midway through the first half, after scoring three converted tries in a frenetic eight minute period. ", "The Rabbitohs replied in equally quick time to draw level at 24-all with ten minutes left to play in the first half. ", "Jets fullback Nathan Merritt scored his third try just before half-time for Newtown to go the break leading by 28-24.", "\n\nThe Jets scored first in the second half but the Rabbitohs largely controlled the second session, especially as their bigger forwards and interchange players took charge late in the game. ", "The scores were tied up at 36-all with ten minutes left, but there was a sense of inevitability as to the final outcome, especially with the Rabbitohs? ", "strong kicking game keeping the Jets unsettled. ", "A field goal with five minutes to play, another converted try with three minutes left and a penalty goal right on full-time gave Souths their final winning margin.", "\n\nWhile some of the post-match analysis focus might have been on how Newtown could have blown a 24-6 lead, the detail of the second half tells the full story. ", "Souths had bigger impact players coming from the bench and used them effectively, while Newtown?s defenders repeatedly failed to lock up the Rabbitohs? ", "ball carriers. ", "Souths employed a clever kicking game and were aided by fundamental errors from Newtown, such as twice failing to find touch from penalty kicks.", "\n\nSam Isemonger (pictured) was Newtown?s best forward, setting a strong example with power-laden tackles and full-blooded hit-ups. ", "He was well supported by Jon Green, Luke Douglas, Kevin Kingston and Cameron Ciraldo. ", "While Nathan Merritt didn?t have his happiest day at full-back, he still scored three tries and kicked four goals, adding to his burgeoning points tally for the season. ", "Russell Aitken and Beau Scott were the best of the other Newtown backs.", "\n\nThere was a general bye in the Jim Beam Cup competition this weekend and Parkes had the bye up in Group 11. ", "In the NSWRL Women?s Rugby League, the Newtown Jetettes defeated the previously unbeaten Redfern All Blacks by 20-8.", "\n\nThe Sydney Airport Jets meet the Newcastle Knights this coming Saturday evening (July 16th) at Toyota Park, with this match kicking off at 5.30pm. ", "This game is the main curtain-raiser to the Sharks-Knights NRL fixture starting at 7.30pm. ", "The Jim Beam Cup team has yet another bye this weekend due to the enforced restructuring of the competition draw." ]

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[ "Effects of haloperidol and clozapine administration on oxidative stress in rat brain, liver and serum.", "\nAntipsychotics remain the standard of care for individuals with schizophrenia, despite their association with adverse effects including extrapyramidal symptoms, metabolic syndrome and agranulocytosis. ", "While the biological mechanisms underlying these side effects remain unresolved, it has been proposed that oxidative stress may play a role in their development. ", "The aim of this study was to evaluate markers of oxidative stress associated with first- and second-generation antipsychotics, focusing on protein and lipid oxidation and expression of the antioxidant proteins peroxiredoxin-2 and peroxiredoxin-6. ", "Following 28-day administration of haloperidol, clozapine or saline to adult rats, brain grey matter, white matter, serum and liver samples were obtained and lipid peroxidation, protein oxidation, peroxiredoxin-2 and peroxiredoxin-6 levels quantified. ", "In grey matter, peroxiredoxin-6 was significantly increased in the haloperidol-exposed animals, with a trend towards increased lipid peroxidation also observed in this group. ", "In liver, lipid peroxidation was increased in the clozapine-exposed animals, with a similar trend noted in the haloperidol group. ", "Antipsychotics did not produce significant changes in serum or white matter. ", "Our results suggest that haloperidol and clozapine may induce oxidative stress in brain and liver, respectively, consistent with the documented adverse effects of these agents." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "Insulin secretion levels necessary for efficacy of an alpha-glucosidase inhibitor on glucose metabolism in patients with non-insulin-dependent diabetes mellitus.", "\nTwenty patients with non-insulin-dependent diabetes mellitus whose glucose metabolism was unsatisfactory, even though they were receiving appropriate dietary therapy, were treated with an alpha-glucosidase inhibitor (0.6 mg/day) for 12 weeks. ", "The connecting peptide immunoreactivity value (selected as the evaluation criterion of post-prandial endogenous insulin secretion) was compared in patients with and without improved glycosylated haemoglobin levels. ", "A significant difference was found between the connecting peptide immunoreactivity value of the group with improved glycosylated haemoglobin levels (5.0 +/- 1.0 ng/ml) and that in the group without the improvement (2.7 +/- 0.9 ng/ml)." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "In a rather strange move, Samsung has pushed out the Android 4.4.4 update to the Galaxy S3 Neo before any other device in its lineup, before even the flagships like the Galaxy S5. ", "The update is currently rolling out to the device in Kazakhstan with build number I9300IXXUBNH3; it should be available as an over-the-air download as well as through Kies, though advanced users can also grab the firmware from our firmware section to update manually. ", "As for the changelog, we’re guessing there is nothing major to speak of, and the update should mostly include bug and security fixes that are a part and parcel of Android 4.4.4.", "\n\nAs always, keep in mind that the update will gradually roll out to more regions in the coming weeks. ", "We’ll be sure to let you know when Samsung rolls out the update to other devices, and we will continue hoping that Samsung completes the Android 4.4.4 rollout for eligible devices well in time before Android L comes knocking.", "\n\nFirmware Details:\n\n• Model: GT-I9300I\n\nGT-I9300I • Model name: GALAXY S III\n\n• Country: Kazakhstan\n\n• Version: Android 4.4.4\n\n• Changelist: 2299480\n\n• Build date: Thu, 14 Aug 2014 12:05:43 +0000\n\n• Product Code: SKZ\n\nSKZ • PDA: I9300IXXUBNH3\n\n• CSC: I9300IOXEBNH3\n\n• MODEM: I9300IXXUBNH3\n\nThanks, Serkan!" ]

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[ "Citrix Provisioning Services 5.1 – The soapserver port has been changed to 54321\n\nIf you have had a chance to play with the recenlty released Citrix Provisioning Services 5.1 and XenDesktop, or if you have read through the release notes you will have noticed that there has been a change in the soapserver port in this release, it has been changed to 54321\n\nXenDesktop\nTR-8213:\nThe default SoapServer port has been changed to 54321 to avoid a port collision when the PVS Server and the XenDesktop Server are installed on the same system.", "\nXenDesktop users need to modify the Setup Tool’s configuration file,”SetupToolApplication.exe.config” and change the ports from 8000 to 54321.", "\n\nIf a port conflict is encountered, the SoapServer port can be changed by running the following Mcli command:" ]

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[ "\"CAN YOU SEE IT?\" \"", "TAKE YOUR TIME.\" \"", "CONGRATULATIONS, FATHER.\" \"", "UH HUH.\" \"", "A WEEK LATE, BUT THERE SHE IS.\" \"[", "INDISTINCT] BUT, HE'S COME BACK TO YOU NOW.\" \"", "THANK YOU.\" \"", "YOU SEE HIM, MERCEDES?\" \"", "MONSIEUR MORRELL.\" \"", "YES, DEAR GIRL.\" \"", "THE FLAG'S AT HALF MAST.\" \"", "FERNAND, WHAT CAN IT BE?\" \"", "EDMUND, MY DEAR BOY.\" \"", "I AM GLAD TO SEE YOU.\" \"", "BUT WHAT DOES THE FLAG MEAN?\" \"", "WHERE IS CAPTAIN LECLERE?\" \"", "WE HAVE HAD A TRAGEDY AT SEA, MONSIEUR.\" \"", "THE CAPTAIN DIED OFF CHIBA DUBEKI, SIR,\" \"OF BRAIN FEVER.\" \"", "LECLERE?\" \"", "DEAD?\" \"", "BURIED AT SEA, SIR.\" \"", "AND THE CARGO?\" \"", "ALL SAFE, SIR.\" \"", "I THINK YOU'LL FIND\" \"EVERYTHING TO YOU SATISFACTION, MONSIEUR MORRELL.\" \"", "YOU'VE DONE WELL.\" \"", "AFTER THE MISFORTUNE, WHO TOOK CHARGE, YOU?\" \"", "YOU KNOW, SIR, SCARCELY WAS THE BREATH OUT\" \"OF THE GOOD CAPTAIN'S BODY THEN MONSIEUR\" \"DANTES ASSUMED COMMAND WITHOUT CONSULTING ANYBODY.\" \"", "AS CAPTAIN'S MATE, IT WAS MY DUTY TO TAKE COMMAND, SIR.\" \"", "YOU DID WELL, MY BOY, VERY WELL.\" \"", "NEXT TO A DEATH AT SEA, EDMOND, DOLESS IS INSIGNIFICANT.\" \"", "BUT WERE THERE ANY OTHER INCIDENTS WHICH SHOULD\" \"BE BROUGHT TO MY ATTENTION?\" \"", "YES, SIR, ONE.\" \"", "BRING THE PRISONER FORWARD.\" \"", "CADEROUSSE?\" \"", "FOUR DAYS AGO, DURING THE BURIAL CEREMONY, HE WAS\" \"CAUGHT PILFERING STORES IN THE FORECASTLE.\" \"", "TRUE, CADEROUSSE?\" \"", "HAVE YOU NOW ADDED PETTY THIEVERY TO YOUR\" \"OTHER ACCOMPLISHMENTS?\" \"", "IF THE ALMIGHTY, MONSIEUR DANTES, SAYS SO, THEN I'M A THIEF.\" \"", "SHALL WE TURN HIM OVER TO THE POLICE?\" \"", "I WOULDN'T IMPRISON ANY MAN USED TO THE\" \"FREEDOM OF THE SEAS, SIR.\" \"", "BUT, I'D NOT HAVE HIM ON MY SHIP.\" \"", "YOUR SHIP, YOUNG MAN?\" \" ", "I SPOKE...\" \" AS ACTING CAPTAIN, I KNOW.\" \"", "AND AS SUCH, WHAT ARE YOUR ORDERS.\" \"", "YOU'RE FREE, CADEROUSSE, BUT DON'T SHOW YOUR FACE TO ME AGAIN.\" \"", "YOU MUST STOP BEING SO GENEROUS TO THE WORLD, MONSIEUR DANTES,\" \"GOD WILL GET JEALOUS.\" \"", "FATHER, DANGLARS TELLS ME THAT ON THE WAY HOME\" \"THE SHIP PUT IN AT ELBA.\" \"", "ELBA?\" \"", "WHY ELBA?\" \"", "MY SHIPS HAVE NO BUSINESS AT ELBA.\" \"", "CAPTAIN'S ORDERS, SIR.\" \"", "AND THE CAPTAIN WAS THE\" \"ONLY MAN TO GO ASHORE.\" \"", "WHY?\" \"", "COULD IT BE THAT HE HAD SOME BUSINESS WITH NAPOLEON?\" \"", "HE DIDN'T TELL ME THE PURPOSE OF HIS VISIT TO THE ISLAND, SIR.\" \"", "STRANGE.\" \"", "VERY STRANGE.\" \"", "DID HE LEAVE ANY PAPERS BEHIND?\" \"", "A WILL?\" \"", "A TESTAMENT?\" \"", "ON HIS DEATHBED, SIR, HE GAVE ME THIS.\" \"", "THERE'S NO ADDRESS ON IT.\" \"", "HE TOLD ME WHERE TO DELIVERY IT, SIR.\" \"", "I HAVE HIS FULL INSTRUCTIONS.\" \"", "WELL, THE MATTER WILL TAKE CARE OF ITSELF.\" \" ", "EDMOND.\" \"", "HUH?\" \"", "AHAA.\" \"", "WELL, WE MUST TALK TO YOU NO LONGER.\" \"", "GO, MY BOY, A FAR MORE IMPORTANT PERSONAGE THAN\" \"OLD MORRELL IS WAITING FOR YOU.\" \"", "GO.\" \"", "MERCEDES.\" \"[", "APPLAUSE]\" \"HEY, ANOTHER MEMBER OF THIS CLUB.\" \"", "WHAT CLUB?\" \"", "THE SOCIETY FOR THE DESTRUCTION OF EDMOND DANTES.\" \"", "YOU WOULD LIKE THAT, WOULDN'T YOU LIEUTENANT?\" \"", "WOULDN'T YOU LIKE A CLEAR PATH TO\" \"YOUR PRETTY LITTLE COUSIN, MERCEDES.\" \"", "DON'T MENTION MERCEDES NAME IN YOUR PUB.\" \"", "SIT DOWN.\" \"", "PLEASE.\" \"", "HOLD IT.\" \"", "BE QUIET.\" \"", "LISTEN TO ME.\" \"", "HEH.\" \"", "I THINK I SEE A WAY TO REMOVE THIS IMPEDIMENT\" \"FROM THE LIVES OF ALL OF US.\" \"", "QUESTION:\" \"WHAT IS THE FATE OF A BONAPARTIST\" \"IN THESE MARCHING TIMES?\" \"", "HE'S A...\" \"BONAPARTIST?\" \"", "ON THE WAY HOME, OUR SHIP PUT IN AT ELBA.\" \"", "THE CAPTAIN WENT ASHORE.\" \"", "TWO DAYS LATER, BEFORE HE DIED, HE HANDED DANTES AN ENVELOPE.\" \" ", "SO?\" \" ", "SO USE YOUR IMAGINATION.\" \"", "I'M SUGGESTING THAT CAPTAIN LECLERE WENT ASHORE TO\" \"CONSORT WITH NAPOLEON BONAPARTE HIMSELF.\" \"", "I'M SUGGESTING THAT\" \"ENVELOPE CONTAINS SECRET ORDERS.\" \"", "I'M PROPOSING THAT WE TAKE\" \"ADVANTAGE OF THE POSSIBILITIES IN THIS SITUATION.\" \"", "WAKE UP.\" \"", "HEY PAPER, INK!\" \"", "ONE MOMENT MONSIEUR.\" \"", "PLEASE, JUST A MOMENT.\" \"", "EDMOND.\" \"", "YES, FATHER.\" \"", "I'M AN OLD MAN WITHOUT MANNERS, BUT I MUST ASK MISS HIGGENS A QUESTION.\" \"", "WHAT IS IT?\" \"", "THAT YOUNG LIEUTENANT, YOUR COUSIN, FERNAND MANDEGO,\" \"I'M TOLD HE LOVES YOU, TOO.\" \"", "FERNAND MANDEGO HAS LOVED AND LOST.\" \"", "THE WAY OF THE WORLD, FATHER.\" \"", "FERNANDI IS A FIERY YOUNG MAN.\" \"", "A SPANIARD.\" \"", "I DO NOT WANT YOU COMING AT YOU ONE DARK NIGHT,\" \"WITH THAT LONG KNIFE.\" \"", "MY BLADE IS A MATCH FOR ANY SPANIARD KNIFE.\" \"", "BUT...\" \"FATHER, THIS IS NO TIME FOR BAD THOUGHTS.\" \"", "WE HAVE GOOD NEWS FOR YOU TONIGHT.\" \"", "YES, TELL HIM NOW.\" \"", "NOW, MANDEGO I THINK YOU'D BETTER WRITE IT.\" \"", "MINE IS TOO FINE A HAND.\" \"", "HA, HA, THIS REQUIRES\" \"SOMETHING A LITTLE ROUGHER.\" \"", "UH, ADDRESS IT, UH,...\" \"THE PROSECUTOR, THE PORT OF MARSEILLE.\" \"", "THE PROSECUTOR, UH, BEGIN AS FOLLOWS, UH, MONSIEUR.\" \"", "A CAPTAIN?\" \"", "YES, I'VE BEEN MADE CAPTAIN.\" \"", "WITH A HUNDRED GOLD SOVEREIGNS PAID PER VOYAGE AND A SHARE OF THE PROFITS.\" \"", "MY BOY, MY BOY!\" \"", "TELL HIM THE REST.\" \"", "WITH THE FIRST MONEY I TOUCH, I MEAN YOU TO HAVE\" \"A HOUSE OF YOUR OWN, WITH A GARDEN,\" \"TO PLANT YOUR LARKSPUR, YOUR ROSES, YOUR FLOWERING VINES...\" \" WHAT DO YOU SEE?\" \"", "OH, NOTHING.\" \"", "NOTHING.\" \"", "MAY I NOW PRONOUNCE YOU MAN AND WIFE.\" \"", "NOW, WHEN I SAY THOSE WORDS, TOMORROW,\" \"THE GROOM WILL KISS THE BRIDE.\" \"", "OH, NOT NOW, TOMORROW, I SAID.\" \"", "AT WEDDING TOMORROW.\" \"", "NOW, THE ORGAN WILL BEGAN AGAIN,\" \"AND YOU WILL TAKE HER BY THE ARM\" \"AND LEAD HERE UP THE AISLE, OUT OF THE CHURCH.\" \"", "DO IT, DO IT, DO IT.\" \"", "NOW THEN FAMILY AND FRIENDS WILL TURN AND FOLLOW THEM UP THE AISLE.\" \"", "NO, NO, TOMORROW, I SAID.\" \"", "NOT TODAY.\" \"", "TOMORROW, TOMORROW, I SAID.\" \"[", "LAUGHTER] ...TOMORROW.\" \"", "FOR THE WEDDING.\" \"", "DON'T FORGET!\" \"", "HA, HA, HA.\" \"", "EDMOND DANTES!\" \"", "THAT'S MY NAME, MONSIEUR.\" \"", "YOU'RE UNDER ARREST!\" \"", "WHAT'S THE MEANING OF THIS?\" \"", "WHAT IS MY OFFENCE?\" \"", "EDMOND!\" \"", "OH, WHAT IS HAPPENING.\" \"", "TAKE YOUR HANDS OFF HER!\" \"", "DON'T TOUCH HER!\" \"", "YOU ARE THE MATE OF THE ARGUS?\" \" ", "YES, MONSIEUR LE PROSECUTOR.\" \"", "YOU DON'T SEEM TO BE DRESSED FOR A CONSPIRACY.\" \"", "CONSPIRACY?\" \"", "I WAS ARRESTED AT THE REHEARSAL FOR MY WEDDING.\" \"", "TOMORROW, I'M TO BE MARRIED.\" \"", "HAVE YOU EVER SERVED UNDER THE USURPER, BONAPARTE?\" \"", "BONAPARTE?\" \"", "BONAPARTE, WHAT ARE YOU SAYING, MONSIEUR?\" \"", "I DON'T...\" \"IT IS REPORTED THAT YOUR POLITICAL AFFINITIES ARE EXTREMIST.\" \"", "AFFINITIES, MONSIEUR DE VILLE FORT ALL I KNOW\" \"IS MY WORK.\" \"", "I LOVE THE SEA.\" \"", "I LOVE MY FIANCÉ.\" \"", "I LOVE MY FATHER.\" \"", "THESE ARE MY AFFINITIES.\" \"", "IF THEY ARE POLITICAL THAN\" \"THEY ARE, AS YOU SAY, SIR, EXTREMIST.\" \"", "I BELIEVE THAT.\" \"", "DO YOU RECOGNIZE THIS WRITING?\" \"", "NO, SIR.\" \"", "ARE YOU SURE?\" \"", "IS IT TRUE?\" \"", "NO SIR.\" \"", "DID YOUR CAPTAIN GIVE YOU AN ENVELOPE?\" \"", "YES, SIR.\" \"", "WHERE IS IT?\" \"", "I CARRY IT WITH ME.\" \"", "GIVE IT TO ME.\" \"", "I GAVE HIM MY WORD, SIR.\" \"", "I ORDER YOU, IN THE NAME OF THE KING TO GIVE IT TO ME.\" \"", "IN THE NAME OF THE KING, OF COURSE.\" \"", "WHAT DOES IT SAY, MONSIEUR.\" \"", "HAD YOU KNOWN THE CONTENTS OF THIS LETTER,\" \"YOU WOULDN'T BE CARRYING IT ON YOUR PERSON.\" \"", "YOU WOULD HAVE DENIED ANY KNOWLEDGE OF IT\" \"WHEN I ASKED FOR IT.\" \"", "AS YOU ACTUALLY SURRENDERED IT TO ME,\" \"IT CLEARLY ESTABLISHES YOUR INNOCENCE OF ANY\" \"COMPLICITY IN THIS AFFAIR.\" \"", "THEN...\" \"IF I AM INNOCENT, MONSIEUR..\" \"YOU MAY GO BACK TO YOUR BRIDE-TO-BE.\" \"", "GOD BLESS YOU, MONSIEUR DE VILLEFORT.\" \"", "OH, ONE MORE THING.\" \"", "YES, MONSIEUR.\" \"", "I SEE NO ADDRESS ON THE ENVELOPE.\" \"", "I WAS TOLD WHEN AND WHERE TO DELIVER IT.\" \"", "WHEN?\" \"", "TONIGHT, SIR.\" \"", "TO WHAT ADDRESS?\" \"", "15 AVENUE MONTAIGNE.\" \"", "TO ANY PARTICULAR PERSON THERE?\" \"", "YES, SIR, A MONSIEUR NOIRTIER.\" \"", "SAY THE NAME ONCE MORE.\" \"", "FANCOIS DE NOIRTIER.\" \"", "IS THAT ALL, MONSIEUR?\" \"", "MAY I GO...\" \"NO, NO.\" \"", "THERE ARE A FEW MORE QUESTIONS.\" \"", "DO YOU KNOW THIS PERSON?\" \"", "THIS NOIRTIER?\" \"", "OH, NO SIR.\" \"", "HAVE YOU SPOKEN HIS NAME TO ANYONE?\" \"", "TO NO ONE BUT YOU, SIR.\" \"", "GOOD.\" \"", "I AM SORRY TO TELL YOU THIS, BUT I CANNOT DISMISS YOU RIGHT NOW.\" \"", "WHY NOT, MONSIEUR?\" \"", "YOURS IS A POLITICAL ARREST.\" \"", "I MUST DETAIN YOU OVERNIGHT.\" \"", "THAT IS THE LAW, UNFORTUNATELY.\" \"", "YOU WILL BE DISMISSED IN THE MORNING.\" \"", "I GUARANTEE IT.\" \"", "YOU SEE, THE PRINCIPAL CHARGE AGAINST YOU\" \"IS THIS LETTER.\" \"", "WITHOUT THE LETTER, THERE IS NO EVIDENCE AGAINST YOU, WHATSOEVER.\" \"", "MONSIEUR DE VILLEFORT, YOU ARE A GOOD MAN.\" \"[", "CHUCKLES]\" \"NOW LISTEN CAREFULLY, SHOULD ANYONE INTERROGATE YOU,\" \"YOU DON'T SPEAK A WORD ABOUT THIS LETTER.\" \"", "NO, SIR, I WILL NOT.\" \"", "AND YOU HAVE NEVER HEARD THE NAME OF NOIRTIER.\" \"", "NEVER!\" \"", "SPLENDID.\" \"[", "RINGS BELL]\" \"YOU WILL BE TAKEN TO THE PALAIS DE JUSTICE\" \"JUST FOR THE NIGHT, SO DON'T WORRY.\" \"", "IT IS ONLY A FORMALITY.\" \"", "TAKE HIM.\" \"[", "DOOR CLOSES]\" \"NOIRTIER.\" \"", "NOIRTIER.\" \"", "MUST THAT NAME PURSUE ME LIKE A DEMON TO MY GRAVE?\" \"", "PARDON, MONSIEUR, THIS IS NOT THE WAY TO THE PALAIS DE JUSTICE...\" \"[THUD]\" \"MONSIEUR, IN THE NAME OF MERCY, WHERE ARE YOU TAKING ME?\" \"", "I'LL GIVE YOU IN THE NAME OF MERCY GOOD ADVICE...\" \"CLOSE YOUR MOUTH.\" \"", "MONSIEUR DE VILLEFORT TOLD ME WE WERE TO GO TO THE...\" \"YOUNG MAN, ALWAYS FOLLOW GOOD ADVICE...\" \"[STOMP]\" \"[DOOR OPENS]\" \"GOOD EVENING, MONSIEUR NOIRTIER.\" \"", "WHAT THE DEVIL...\" \"YOU WERE EXPECTING A MESSENGER.\" \"", "BUT NOT YOU.\" \"", "THAT'S IMPOSSIBLE.\" \"", "ME, NO, NO.\" \"", "TO PUT THE CIRCUMSTANCE\" \"IN A NUTSHELL, YOUR MESSENGER WAS INTERCEPTED, FATHER.\" \"", "AND THE MESSAGE.\" \"", "DESTROYED.\" \"", "SIT DOWN.\" \"", "THE PAPER WAS DESTROYED.\" \"", "THE MESSAGE IS NOW WRITTEN\" \"IN HERE.\" \"", "WRITTEN IN TACT, NAMES, DATES, PLACES.\" \"", "ALL THE LITTLE DETAILS OF YOU PRECIOUS LITTLE\" \"EMPEROR'S INTENDED ESCAPE FROM ELBA.\" \"", "I HAVE NO INTENTION OF TELLING IT TO YOU.\" \"", "NICE TO SEE YOU, MY SON.\" \"", "NICE TO SEE YOU, FATHER.\" \"", "I KNOW YOU WOULD NEVER BETRAY YOUR COMRADES,\" \"BUT BETRAY THEM, YOU WILL, IF YOU DON'T DO EXACTLY\" \"AS I SAY.\" \"", "FOR I WILL THEN REVEAL ALL THEIR NAMES\" \"TO THE POLICE.\" \"", "ALWAYS THE CUNNING DEVIL.\" \"", "EVER THE SELFISH LITTLE BEAST.\" \"", "YOU HAVE BEEN MY SECRET EMBARRASSMENT\" \"EVER SINCE I STARTED MY PUBLIC CAREER.\" \"", "MY OWN FATHER, A FOLLOWER OF NAPOLEON.\" \"", "I HAVE LIVED WITH THE FEAR OF DISCOVERY LONG ENOUGH.\" \"", "YOUR DAYS IN THIS FOOLISH CAUSE ARE NOW OVER.\" \"", "FROM NOW ON, YOU WILL NEVER BE OUT OF MY SIGHT.\" \"", "INDEED, YOU COME WITH ME TO PARIS, TONIGHT.\" \"", "TO PARIS?\" \"", "YES, YES, IT SEEMS I HAVE NEWS FOR HIS MAJESTY'S GOVERNMENT.\" \"", "UH, DON'T WORRY, I WILL GIVE NO NAMES INVOLVED IN THE ESCAPE.\" \"", "ONLY THE FACTS.\" \"", "THEY SHOULD BE ENOUGH, I THINK, TO ASTONISH\" \"THE BUREAUCRACY OF PARIS, AND BRING ME TO THE ATTENTION\" \"OF THE KING, HIMSELF.\" \"", "YOU WILL SOON BE THE FATHER OF AN IMPORTANT MAN.\" \"", "DOESN'T THAT...\" \"PLEASE YOU?\" \"", "IT SHOULD.\" \"", "YOU'RE NOT TAKING ME THERE!\" \"", "HELP!\" \"", "HELLLLLLP!\" \"[", "POUNDING ON DOOR]\" \" YOU THERE, KEEP QUIET!\" \"", "WHERE AM I?\" \"", "TELL ME WHERE I AM.\" \"[", "LAUGHTER]\" \" MY FRIEND, YOU ARE NOW IN RESIDENCE AT THE CHATEAU D'IF.\" \"", "THERE'S BEEN A MISTAKE.\" \"", "I WAS ORDERED TO THE PALAIS DE JUSTICE.\" \"", "IT WAS MONSIEUR DE VILLEFORT ORDERS.\" \"", "SEND FOR MONSIEUR DE VILLEFORT.\" \" ", "WOULD YOU LIKE ME TO SEND FOR THE KING AS WELL, OR THE QUEEN?\" \"[", "LAUGHTER]\" \"COME BACK.\" \"", "MONSIEUR DE VILLEFORT IS MY FRIEND.\" \"", "HE WILL BE VERY ANGRY.\" \"[", "LAUGHTER] COME BACK!\" \"", "AT LEAST TAKE A LETTER...\" \"[LAUGHTER]\" \"TO MY WIFE.\" \"", "WHAT HAVE I DONE?\" \"", "WHAT IS MY CRIME?\" \"[", "DOOR WINDOW OPENS] BREAKFAST.\" \"", "LISTEN TO ME A MOMENT.\" \"", "JUST ONE MOMENT.\" \"[", "WINDOW CLOSES]\" \"TELL ME, HOW CAN I ARRANGE TO SEE THE WARDEN?\" \"", "SOMEDAY.\" \"", "SOMEDAY?\" \"", "BUT I'M TO BE RELEASED TODAY...\" \"TODAY!\" \"", "M. DE VILLEFORT'S ORDERS.\" \" ", "AND WHO IS M. DE VILLEFORT?\" \"[", "CLATTER OF FOOD TRAY]\" \"MERCEDES.\" \"[", "DOOR PORTAL OPENS]\" \"HA, HA, HA.\" \"", "HUNGRY YET, MONSIEUR?\" \"", "ARE DO WE STARVE ONE MORE DAY?\" \"", "WAIT.\" \"", "WAIT.\" \"", "AHHH.\" \"", "NASTY LITTLE STOMACH.\" \"", "WINDS OVER TO NIGHT LITE ONCE AGAIN?\" \"", "VERY WELL.\" \"[", "SCREAMING]\" \"[CHIPPING SOUND]\" \"[SCRAPING SOUND]\" \"[TAPPING ON STONE]\" \"HELLO!\" \"", "HELLO.\" \"", "ARE YOU A PRISONER?\" \"", "CAN YOU HEAR ME?\" \" ", "WHO ARE YOU?\" \"", "EDMOND DANTES.\" \" ", "WHY ARE YOU HERE?\" \"", "THEY SAID I WAS A BONAPARTIST.\" \" ", "HOW LONG HAVE YOU BEEN HERE?\" \"", "I DON'T KNOW.\" \"", "I WAS IMPRISONED ON 28 FEB, 1815.\" \" ", "TEN YEARS.\" \"", "HOW LONG HAVE YOU BEEN HERE?\" \" ", "I WILL PUSH THE STONE FROM THIS SIDE.\" \"[", "SCRAPING SOUND]\" \"[BEGINNING LAUGHTER]\" \"[LAUGHTER]\" \"I AM THE ABBE FARIA.\" \"", "BORN IN ITALY.\" \"", "RAISED A PRIEST IN ITALY\" \"I'VE BEEN IN THIS PLACE SINCE EIGHTEEN HUNDRED AND TEN.\" \"", "FIFTEEN YEARS.\" \"", "THE GLORIOUS WISDOM OF THE POLITICAL WORLD,\" \"MONSIEUR DANTES, YOU'RE HERE BECAUSE THEY SAID\" \"YOU WERE WITH BONAPARTE, I WAS IMPRISONED FOR BEING\" \"AGAINST HIM.\" \"[", "CHUCKLE]\" \"FIVE YEARS AGO I LAID MY PLANS FOR ESCAPE.\" \"", "MY CALCULATIONS TOOK ME A YEAR.\" \"", "TO MAKE THE NECESSARY TOOLS TOOK ME A YEAR.\" \"", "I'VE BEEN DIGGING FOR THREE YEARS.\" \"[", "WHISPERING] THREE YEARS.\" \"", "I HAD BUT ONE MATHEMATICAL INSTRUMENT, THIS ONE.\" \"", "NOW I FIND IT WAS GUILTY OF AN INACCURACY.\" \"", "I TOOK THIS WALL FOR THE SEA WALL OF THE PRISON.\" \"", "I CALCULATED 40 DEGREES INSTEAD OF 50.\" \"", "YOU WERE DIGGING FOR THE SEA WALL?\" \"", "UHH.\" \"", "COME WITH ME.\" \"", "AHH.\" \"", "MY MALLET.\" \"", "CHISEL.\" \"", "WHERE DID YOU GET THEM?\" \"", "I MADE THEM.\" \"[", "STONE PLOPS AND SCRAPES]\" \"[HEAVY BREATHING]\" \"[GRUNTING]\" \"WHAT IS THIS?\" \"", "IN SIMPLE TERMS, IT MEANS A QUARTER PAST 12 O'CLOCK.\" \"", "A CLOCK.\" \"", "A CLOCK, A CALENDAR, AN ASTRONOMICAL CHART.\" \"", "HERE, I WILL SHOW YOU.\" \"", "MY BOOK.\" \"", "MY....\" \"NEEDLE, MADE FROM A FISHBONE,\" \"LIKE MY CHISEL MADE FROM ONE OF THE IRONS IN MY BEDSTEAD,\" \"LIKE MY PINCERS, AND MY KNIFE AND MY LAMP.\" \" ", "A LAMP NEEDS OIL.\" \" ", "WHICH I MAKE FROM THE\" \"SUET FROM THE MEAT THEY GIVE US ON HOLY DAYS.\" \"", "HOW DO YOU LIGHT YOUR LAMP?\" \"", "OH, I CLAIM TO HAVE A SKIN DISEASE.\" \"", "I SOMETIMES ASK FOR SULPHUR.\" \"", "TO RELIEVE THE PAIN.\" \"", "FROM WHICH I REPLENISH MY MATCH.\" \"", "HAAA.\" \"[", "GASPING]\" \"UM.\" \"", "NOW.\" \"", "ALL THIS TALENT FOR MY HOPE AND SALVATION.\" \"", "NOW MY DEAD HOPE.\" \"", "FIVE YEARS SPENT ON A TUNNEL THAT LEADS NOT\" \"TO FREEDOM, BUT TO ANOTHER MAN'S CELL.\" \"", "ABBE FARIA, LISTEN, YOUR TUNNEL RUNS IN THE SAME DIRECTION AS\" \"THE OUTER GALLERY.\" \"", "YES.\" \"", "THE SEA WALL IS HERE, I CAN JUST GLIMPSE IT\" \"FROM MY WINDOW.\" \"", "HALF YOUR TUNNEL RUNS IN THE RIGHT DIRECTION.\" \"", "FROM THE CENTER POINT WE TURNED, YOU CALL IT 50 DEGREES.\" \"", "I SAY TWO POINTS MORE NORTH BY NORTHEAST.\" \"", "AND DIG TO THE SEA WALL ABOUT A HUNDRED METERS.\" \"", "HALF MY TUNNEL RUNS IN THE RIGHT DIRECTION?\" \"", "HOW LONG WILL IT TAKE?\" \"", "TWO OF US, FOUR YEARS.\" \"", "AND WHILE WE WORK, WILL YOU TEACH ME,\" \"ALL THE THINGS YOU KNOW?\" \"", "YES.\" \"", "MATHEMATICS, THEOLOGY, PHILOSOPHY, LIVING LANGUAGES\" \" AND DEAD LANGUAGES.\" \"", "THE HISTORY OF THE WORLD.\" \"", "I GIVE THANKS TO HEAVEN.\" \"", "I'LL BE ABLE TO TEACH ONCE MORE.\" \" ", "EDMOND, FOR TODAY'S LESSON IN PHILOSOPHICAL LOGIC,\" \" LET'S PLY OUR BRAINS IN SOME DEDUCTIVE THINKING IN THE CASE\" \" OF EDMOND DANTES.\" \"", "FIRST, TO WHOM COULD YOUR IMPRISONMENT, YOUR DISAPPEARANCE,\" \"HAVE BEEN OF SOME BENEFIT?\" \"", "CONSIDER, YOU WERE ABOUT TO BE\" \"APPOINTED CAPTAIN OF THE ARGUS.\" \"", "TO WHOM WOULD THAT POSITION GO\" \" IF YOU SUDDENLY VANISHED?\" \"", "DANGLARS.\" \"", "ITEM:\" \"WHO WOULD MERCEDES TURN TO WERE EDMOND DANTES\" \" SUDDENLY TO VANISH?\" \"", "MONDEGO.\" \"", "ITEM:\" \"ONE NIGHT YOU SAW DANGLARS AND MONDEGO IN A\" \" CAFE WRITING,...\" \"WITH?\" \" ", "CADEROUSSE!\" \"", "COULD THEY HAVE BEEN WRITING THE LETTER THAT ACCUSED YOU,\" \" THESE THREE?\" \" ", "DANGLARS, MONDEGO, CADEROUSSE!\" \"", "YOU WERE EXAMINED BY THE PROSECUTOR OF THE PORT,\" \"WHO WAS VERY SYMPATHETIC.\" \"", "HE BURNED THE LETTER WHICH\" \"WAS ADDRESSED TO A NOIRTIER.\" \"[", "HAMMERS A STAKE]\" \"NOIRTIER.\" \"", "NOIRTIER, I KNEW A PERSON OF THAT NAME AT THE COURT\" \"OF THE QUEEN OF ETRURIA, AN ARDENT DISCIPLE OF NAPOLEON.\" \"", "EDMOND, WHAT WAS YOUR PROSECUTOR CALLED?\" \"", "DE VILLEFORT.\" \"", "DUH!\" \"", "HAH!\" \"", "HA, HA, HA, HA, HA.\" \"", "WHAT DID I SAY?\" \"", "YOU HAVE UNLOCKED THE WHOLE MYSTERY.\" \"", "MY FRIEND, AT THE COURT OF ETRURIA THE MOST\" \"ARDENT BONAPARTIST I'VE EVER KNOWN.\" \"", "HIS NAME WAS NOIRTIER DE VILLEFORT.\" \"", "HIS BROTHER?\" \"", "NO, MY AGE.\" \"", "HIS FATHER!\" \"", "I PRESUME SO.\" \"", "HIS OWN FATHER A BONAPARTIST?\" \"", "SO, HE DESTROYS YOUR LETTER,...\" \"AND ME.\" \" ", "AND YOU.\" \"[", "THE BEGINNINGS OF REVENGE]\" \"PREY GOD!\" \"", "MONDEGO!\" \"", "SOMETIMES I REGRET THAT I HELPED HIM DISCOVER THE TRUTH.\" \"", "I SEE TOO MUCH IN HIS FACE THAT WAS NEVER THERE BEFORE.\" \"", "MONDEGO.\" \"", "MONDEGO!\" \"", "VENGEANCE BELONGS TO THE LORD, EDMOND.\" \"", "TURN AWAY FROM SUCH UNHOLY THOUGHTS\" \"BEFORE THEY DESTROY YOU.\" \"", "CADEROUSSE!\" \"", "DE VILLEFORT!\" \"", "DANGLERS!\" \"[", "GASP]\" \"UMMM.\" \"[", "SIGH]\" \"UMMM.\" \"[", "SIGH]\" \"EDMOND.\" \"", "EDMOND.\" \"", "DEAR GOD, WHAT IS IT?\" \"", "EDMOND, I'M ILL.\" \"[", "GRUNTING]\" \"I'M DYING.\" \"", "YOU MUST LIVE.\" \"", "I'LL FINISH THE TUNNEL, MYSELF.\" \"[", "GASP] EDMOND, [GASP], YOU MUST FINISH THE TUNNEL AND ESCAPE.\" \"", "FIND THE TREASURE.\" \"", "TREASURE?\" \"", "A MAP.\" \"", "OF THE ISLAND OF MONTE CRISTO.\" \"", "THIS IS THE LOST MAP OF CHEZURE'S FATHER.\" \"", "WITH WHO'S DEATH IN 1498 VANISHED ONE OF THE GREAT\" \"TREASURES OF THE WORLD.\" \"[", "GASP] THIS FORTUNE HAS BEEN BURIED ON MONTE CRISTO FOR\" \"THREE AND A HALF CENTURIES.\" \"", "OH, EDMOND, I WANTED US\" \"TO FIND THIS TREASURE TOGETHER.\" \"", "NOW IT IS FOR YOU TO FIND ALONE.\" \"", "DO GREAT CHARITABLE DEEDS WITH THIS.\" \"[", "GASP] SPEND THIS FORTUNE,\" \"WHICH GOD HAS BEEN HOARDING FOR YOU,\" \"IN GOOD AND HOLY WAYS.\" \"[", "GASP] EDMOND, YOU MUST ESCAPE\" \"AND FIND THE TREASURE.\" \"", "MY PROFESSION FORBADE ME TO MARRY, SO YOU ARE MY SON,\" \"THE CHILD OF MY CAPTIVITY.\" \"", "MAKE THY WORKS OF GOODNESS A MEMORIAL TO ME.\" \"", "WHAT IS SUCH TREASURE TO ME?\" \"", "MY REAL TREASURE LIES HERE.\" \"", "YOU HAVE ENRICHED ME BEYOND...\" \"AH!\" \"", "OHHHHHH!\" \"[", "SLAP]\" \"[CRYING]\" \"[JAILOR COMING]\" \"[CELL WINDOW OPENS]\" \"[BREAKFAST]\" \"[CELL WINDOW CLOSES]\" \"YEAH, HE'S DONE ALL RIGHT.\" \"", "THE POOR OLD LUNATIC.\" \"", "I'LL GET THE SACK.\" \"", "WELL, NOW WE WAIT FOR THE TIDE TO CHANGE.\" \"", "COME ON.\" \"", "HE'S HEAVY\" \"[SPLASH]\" \"[BREATHING HEAVILY]\" \"HERE.\" \" ", "HE'S HALF DEAD.\" \" ", "NO, HE'S HALF ALIVE.\" \" ", "WAKE UP, OLD MAN.\" \" ", "HOW DO YOU KNOW THAT, ISOLDE?\" \"", "LOOK AT HIM.\" \"[", "COUGHING]\" \"[BREATHING HEAVILY]\" \"WHERE AM I?\" \"", "ABOARD THE GOOD SHIP LAGORNA, OUT OF CORSICA.\" \"", "I AM THE CAPTAIN.\" \"", "BERTUCCIO, IS MY NAME.\" \"", "THIS IS MY MATE, JACOPO.\" \"", "HAA.\" \"", "WHAT ARE YOU?\" \"", "HUH?\" \"", "WHAT IS YOU NAME?\" \"", "WHERE DO YOU GO?\" \"", "THE ISLAND OF RHEON.\" \"", "WITH A TOP TWO CURRENT, IT SHOULD TAKE US THERE\" \"IN TWO HOURS.\" \"", "YOU KNOW THESE WATERS, EH?\" \"", "BERTUCCIO, JACOPO, WHAT ARE ITALIANS DOING IN THESE WATERS?\" \"", "I THINK YOU ALREADY GUESSED.\" \"", "HOW IS THE SMUGGLING THESE DAYS, GOOD?\" \"", "TERRIBLE.\" \"", "WE NEED A NAVIGATOR.\" \"", "A NAVIGATOR WHO KNOW HIS WAY\" \"IN THIS JUNGLE OF WATERS.\" \"", "WOULD YOU, WOULD YOU JOIN US?\" \"", "NOW, TELL ME, WHO ARE YOU?\" \"", "WHAT IS YOU NAME?\" \"", "WHERE DO YOU COME FROM?\" \"", "THERE'S NO SIGN OF A SHIP WRECK.\" \"", "THERE'S BEEN NO STORM.\" \"[", "CANNON BOOMS]\" \"THE CANNON OF CHATEAU D'IF.\" \" ", "YOU?\" \" ", "JACOPO.\" \"", "ON THIS BOAT, A MAN'S BUSINESS IS HIS BUSINESS.\" \"[", "CANNON BOOM]\" \"YOU HAVE A YOUNG MAN'S FACE.\" \"", "HOW OLD ARE YOU?\" \" ", "IF THIS IS THE YEAR 1829, IS IT?\" \" ", "OF COURSE\" \"THEN I AM 33 YEARS OLD.\" \"", "AND I WILL BE 34 YEARS OLD.\" \"", "ONLY BECAUSE OF YOU, MY GOOD FRIENDS.\" \"[", "BELLS RINGING]\" \"THE PRIEST WAS THERE.\" \"", "WELL.\" \"", "HE SAID SHE IS MARRIED.\" \"", "TO MONDEGO?\" \"", "TO FERNAND MONDEGO.\" \"", "AND?\" \"", "TELL ME.\" \"", "I DON'T KNOW WHY I MUST BE THE ONE TO TELL.\" \"", "YOUR FATHER IS DEAD.\" \"", "AND EDMOND, THIS BURNS\" \"IN MY THROAT, OF STARVATION.\" \"", "YOUR FATHER DIED OF STARVATION.\" \"[", "THIRST FOR REVENGE GROWS]\" \"DANGLARS!\" \"", "DE VILLEFORT!\" \"", "CADEROUSSE!\" \"", "MONDEGO!\" \"", "GOD HAD DELIVERED ME INTO THE HANDS OF TWO SMUGGLERS,\" \"WHO BREATHED LIFE BACK INTO ME.\" \"", "BEFRIENDED ME ON FAITH ALONE,\" \"ASKING NO QUESTIONS, UNTIL THE DAY I WAS STRONG ENOUGH\" \"TO FULFILL MY PROMISE TO THE ABBEY FARIA.\" \"[", "VOICE OF ABBE FARIA]:\" \"THE ENTIRE PART OF FORTUNE IS BURIED ON MONTE CRISTO.\" \"", "IT'SBEENTHERE FOR THREE AND A HALF CENTURIES.\" \"", "OHEDMOND,IWANTEDUS TO FIND THIS TREASURE TOGETHER.\" \"", "NOWITIS FORYOU TOFIND ALONE.\" \"", "DO GREAT AND CHARITABLE DEEDS WITH THIS.\" \"", "SPEND THIS FORTUNE, WHICH GOD HAS BEEN HOARDING FOR YOU,\" \"IN GOOD AND HOLY WAYS.\" \"", "WAS I ONLY HUMORING FANCIES OF A BELOVED MADMAN?\" \"", "BY COMING TO THE ISLAND OF MONTE CRISTO\" \"WAS I SIMPLY LAYING THE SPIRIT OF THE ABBEY\" \"TO ETERNAL REST?\" \"", "OR WAS THERE A HOPE IN MY HEART OF HEARTS,\" \"THAT HIS MAP WOULD TRULY BE THE END OF THE RAINBOW.\" \"[", "GUNSHOT]\" \"[BAM]\" \"[BAM]\" \"OH, ABBEY FARIA, DEAR PRIEST, DEAR SAINT!\" \"", "I PROMISE YOU BY THE GOD I HAD FOR SO LONG FORSAKEN.\" \"", "I PROMISE YOU WE WILL BUILD YOUR HOSPITALS\" \"AND HOUSE YOUR ORPHANS\" \"I PROMISE YOU THERE WILL BE A FLOOD OF GOOD THINGS\" \"IN A HUNDRED ABANDONED CORNERS OF THE EARTH,\" \"AND ALL IN YOUR NAME.\" \"", "AND I PROMISE YOU, EDMOND DANTES,\" \"IMPRISONED IN THE PRIME OF LIFE.\" \"", "BANISHED FROM THE WORLD FOR FOURTEEN YEARS.\" \"", "I PROMISE YOU, EDMOND DANTES,\" \"YOU SHALL HAVE YOUR REVENGE.\" \"", "JACOPO!\" \"", "BERTUCCIO!\" \"", "THE WORLD IS MINE!\" \"", "HOORAY!\" \"[", "YEARS LATER, EDMOND DANTES HAD BEEN TRANSFORMED]\" \"HE DID SAY A QUARTER AFTER THE HOUR?\" \"", "HE DID, BARON DANGLERS.\" \"", "SUCH PANACHE!\" \"", "HE TAKES THE MOST SPLENDID CASTLE\" \"IN THE WHOLE OF THE LANDSCAPE OF FRANCE.\" \"", "SUCH ABANDONED EXPENSE.\" \"", "HO, HO, MY WORD.\" \"", "HOW THE MAN SPENDS.\" \"", "SUCH MYSTERY!\" \"", "ALL THESE RUMORS OF A HAREEM ON THE TOP OF HIS CASTLE.\" \"", "THESE WHISPERS ABOUT A FLEET OF PIRATE SHIPS\" \"DROWNING THE MEDITERRANEAN.\" \"", "HOW DID HE CONTACT THE BANK?\" \"", "I WAS APPROACHED BY HIS EQUERRY, SIR.\" \"", "A ROUGH LOOKING FELLOW WITH A TERRIBLE SCAR.\" \"", "NERVE!\" \"", "HA, HA, TYPICAL.\" \"", "AN EQUERRY WITH A SCAR.\" \"", "HE HAS ALL THE TRAPPINGS OF THE EXOTIC.\" \"", "MYSTERY CLINGS TO HIM LIKE SCANDAL.\" \"", "WHAT AN AURA OF LEGEND HE'S SPREAD AROUND EUROPE\" \"IN THE LAST FIVE YEARS.\" \"", "HIS OWN INTELLIGENCE NETWORK,\" \"WITH TENTACLES AROUND THE WORLD.\" \"", "A WHOLE ARMY OF AGENTS, CEASELESSLY QUESTING,\" \"QUESTING,\" \"QUESTING, QUESTING FOR WHAT?\" \"", "EARTH?\" \"", "NOBODY KNOWS.\" \"", "AND THIS PASHA OF MYSTERY, THIS MYCENUS FROM NOWHERE,\" \"IS COMING TO SEE ME?\" \"", "HA, HA.\" \"", "WHAT TIME IS MY APPOINTMENT WITH THE PROSECUTOR?\" \"", "NOT UNTIL ELEVEN, MONSIEUR.\" \"", "WHAT IS IT?\" \"", "THE COUNT OF MONTE CRISTO.\" \"", "WHAT, SHOW HIM IN!\" \"", "MY, DEAR COUNT.\" \"", "I AM THE BARON DANGLERS.\" \"", "SIT DOWN.\" \"", "DO SIT DOWN THERE, MONSIEUR DE COMTE.\" \"", "BARON DANGLERS, I CAME TO PARIS INTENDING TO STAY ONLY A MONTH.\" \"", "I'VE SINCE DECIDED TO STAY ON ANOTHER TWO OR THREE.\" \" ", "PARIS WILL BE PROUD...\" \" I'VE BEEN BANKING\" \"OUT OF MY POCKET, THUS FAR.\" \"", "NOW I WISH TO OPEN AN ACCOUNT WITH YOUR ESTABLISHMENT.\" \"", "AS AN OPENING ACCOUNT SHALL WE SAY,... 5 MILLION.\" \"", "OH, THE POWER OF LITTLE PIECES OF PAPER, MY DEAR BARON.\" \" ", "HE, HE, HE, HE,....\" \" AS MARVELOUS ANY\" \"CREATION OF MAN, INCLUDING HIS POETRY, MUSIC AND PAINTING.\" \"", "WHO HANDLES MONEY PROPERLY, IS ALSO AN ARTIST.\" \"", "YES...\" \"YES.\" \"", "FIVE.\" \" ", "WELL, MONSIEUR, I SHALL TAKE, UH...\" \" THE BALANCE I LEAVE TO MY STAFF.\" \"", "I THANK YOU, BARON.\" \"", "MONSIEUR LE COMTE.\" \"", "I AM IMPRESSED BY YOUR HEAD OF IMHOTEP, SIR.\" \"", "A FINE SPECIMEN.\" \"", "IM...\" \"UH...\" \"HOTEP, YES, OH, AND THIS ONE, SIR.\" \"", "A MOST INGENIOUS FAKE.\" \"", "ALL RIGHT, THANK YOU.\" \"", "OH, THANK YOU, THANK YOU, INDEED, SIR.\" \"", "IS THERE ANY OTHER SERVICE WE CAN RENDER IN THE MEANTIME,\" \"SOME CONVENIENCE, UH...\" \"IN POINT OF FACT, BARON.\" \"", "WHATEVER THE COUNT OF MONTE CRISTO MAY DESIRE.\" \"", "I MAKE MY HOME IN THE COUNTRY, MONSIEUR.\" \"", "YES, I KNOW.\" \"", "BUT, NOW, FOR CONVENIENCE, I'VE TAKEN AN APARTMENT\" \"ON THE CHAMPS ELYSEE.\" \"", "I'M TOLD THERE HAVE BEEN RANDOM ROBBERIES IN THE NEIGHBORHOOD.\" \"", "FOR POLICE PROTECTION TO WHOM DOES ONE APPLY?\" \"", "AND ALL PAPERS IN THE CASE SHOULD BE CONSIGNED\" \"TO THE KING'S ATTORNEY.\" \" ", "AT ONCE, MONSIEUR DE VILLEFORT.\" \" ", "THANK YOU.\" \"", "THE BARON DANGLERS.\" \"", "DANGLERS, YOU ARE LATE.\" \"", "MONSIEUR DE VILLEFORT, I HAVE THE HONOR TO PRESENT\" \"THE COUNT OF MONTE CRISTO.\" \"", "THE COUNT OF MONTE CRISTO, MY DEAR COUNT,\" \"WELCOME TO MY HOUSE.\" \"", "MONSIEUR.\" \"", "PLEASE, SIT DOWN.\" \"", "I HOPE I'M NOT INTRUDING ON THE BUSINESS OF THE DAY.\" \"", "INTRUDING?\" \"", "NOT AT ALL.\" \"", "A MINOR MATTER.\" \"", "ALL DISPATCHED WITH.\" \"", "SURELY, YOU'VE BEEN READING\" \"ABOUT THIS CUTTHROAT, JACQUES BIENOIR, WHO KILLED\" \"THE BROTHER OF SENATOR GALLIMAR.\" \"", "YES.\" \"", "HAS A JUDGMENT BEEN REACHED?\" \"", "INDEED, THE GUILLOTINE.\" \"", "IF A MAN TORTURES AND MURDERS YOUR BROTHER OR YOU SON\" \"OR YOUR FATHER,\" \"KILLS ONE OF THOSE BEINGS WHO LEAVE AN ETERNAL EMPTINESS,\" \"AND A BLEEDING WOUND WHEN THEY ARE TORN FROM YOUR HEART,\" \"DO YOU REALLY THINK SOCIETY HAS GIVEN YOU SUFFICIENT\" \"REPARATION BECAUSE THE BLADE OF A GUILLOTINE HAS PASSED\" \"BETWEEN THE MURDER'S TRAPEZIOUS AND HIS OCCIPITAL BONE?\" \"", "BECAUSE THE MAN WHO HAS CAUSED YOU IMMEASURABLE\" \"SUFFERING HAS ENDURED A FEW SECONDS OF PHYSICAL PAIN?\" \"", "MY DEAR COUNT, ARE YOU SUGGESTING THE MEDIEVAL WAY,\" \"TORTURE?\" \"", "I AM SUGGESTING THE HOLY REMEDY.\" \"", "AN EYE FOR AN EYE.\" \"", "YES.\" \"", "YES, INDEED, INDEED.\" \"", "VERY INTERESTING.\" \"", "HA, WELL, UH, WHEN THE COUNT MENTIONED TO ME THAT HE WAS SEEKING\" \"POLICE PROTECTION FOR HIS RESIDENCE, I TOOK THE LIBERTY...\" \"THIS OFFICE IT AT HIS SERVICE OF THE COUNT OF MONTE CRISTO.\" \"", "WE CAN POST POLICE OFFICIALS ON BOTH STREETS OF HIS RESIDENCE,\" \"FRONT AND REAR.\" \"", "AS MANY AS YOU MAY DESIRE.\" \"", "MONSIEUR DE VILLEFORT IS TOO GENEROUS.\" \"", "PARIS MUST DO ITS VERY BEST FOR DISTINGUISHED VISITORS.\" \"[", "DOOR OPENS]\" \"FATHER, YOU PROMISED TO COME AND SEE GRANDFATHER, THIS MORNING.\" \"", "THE MORNING IS HALF GONE.\" \"", "YOU KNOW HIS REST.\" \"", "GOOD MORNING, BARON DANGLERS.\" \"", "GOOD MORNING, SIR.\" \"", "HOW LONG WILL YOU...\" \"YOU KNOW HE MUST NEED A NAP.\" \"", "WHEN DO YOU HAVE SUCH VISITORS, FATHER?\" \"", "THIS GENTLEMAN DOESN'T LOOK LIKE A CRIMINAL OR A LAWYER.\" \"[", "CHUCKLE] I'M AFRAID MY DAUGHTER IS OUTSPOKEN TO A FAULT.\" \"", "AND SLIGHTLY ILL-MANNERED.\" \"", "PLEASE, FORGIVE HER.\" \" ", "FATHER.\" \" ", "VALENTINE,\" \"I HAVE THE HONOR TO PRESENT THE COUNT OF MONTE CRISTO.\" \"", "MONTE CRISTO!\" \"", "OH, SIR, I SHALL BE THE ENVY OF\" \"EVERY GIRL IN PARIS.\" \"", "WHAT THEY'RE SAYING IS TRUE.\" \"", "YOU ARE HANDSOME.\" \"", "ARE YOU AS RICH AS THEY SAY, MONSIEUR?\" \"", "RICH IN EXPERIENCE, MADEMOISELLE.\" \"", "RICH IN YEARS.\" \"", "AND GROWING RICHER BY THE MOMENT\" \"IN MY APPRECIATION OF THE LOVELINESS OF PARIS.\" \"", "MONSIEUR, ARE YOU BUSY?\" \"", "DO ME THE GREATEST OF FAVORS.\" \"", "WILL YOU COME TO MEET MY GRANDFATHER?\" \" ", "VALENTINE, WILL YOU STOP THIS NONSENSE?\" \"", "HE WILL BRIGHTEN LIKE THE LILIES.\" \"", "COME.\" \"", "MADEMOISELLE HONORS ME.\" \"", "THE COUNT OF MONTE CRISTO.\" \"", "HOW EXTRAORDINARY.\" \"", "BUT HOW DID YOU MANAGE TO BRING HIM HERE?\" \"", "AS A MATTER OF FACT, IT WASN'T EASY.\" \"", "GRANDFATHER, I BRING YOU THE COUNT OF MONTE CRISTO.\" \"", "HERE, YOU SEE HOW HE SMILES.\" \"", "AMIDST ALL KINDS OF .....\" \"AND I BRING HIM TO YOUR ROOM.\" \"", "MONSIEUR LE COMTE, MY GRANDFATHER,\" \"MONSIEUR DE NOIRTIER DE VILLEFORT.\" \"", "HONORED, MONSIEUR.\" \"", "MY GRANDFATHER IS PARALYZED, MONSIEUR\" \"FROM AN OLD WOULD AT AUSTERLITZ.\" \"", "HE CAN SPEAK ONLY WITH HIS EYES.\" \"", "WHAT IS IT YOU WANT, GRANDFATHER?\" \"", "ANOTHER PILLOW?\" \"", "SOME WATER?\" \"", "A, B, C, D, E, F, G [BLINK]\" \"G. VALOIS, HE WANTS HIS GLASSES.\" \"", "HE'S DELIGHTED TO SEE YOU.\" \"", "ARE YOU NOT, GRANDFATHER?\" \"", "WHAT OTHER MAN WHICH DO WE NEED?\" \"", "VALOIS, IS IT TIME TO START HIS MEAL?\" \"", "MY GRANDFATHER IS A PRISONER OF HIS BODY, MONSIEUR.\" \"", "BUT HIS WILL IS LIKE HIS MIND, UNCONQUERABLE.\" \"", "HE POSSESSES WHAT FEW MEN CAN BOAST OF,\" \"THE DEVOTION OF ONE LOVING HEART.\" \"", "THAT'S A LONELY STATEMENT, MONSIEUR.\" \"", "MONSIEUR ALBERT IS HERE, MADEMOISELLE.\" \"", "ALBERT!\" \"", "OH, MONSIEUR, PLEASE.\" \"", "I SHALL RETURN IMMEDIATELY.\" \"", "YOU MUST EXCUSE ME, SIR, IF I SEEM TO STARE.\" \"", "IT DOESN'T OFTEN HAPPEN THAT A MAN CAN GAZE UPON THE ONE\" \"GREAT NEMESIS OF HIS LIFE.\" \"", "DON'T STRAIN FOR EXPLANATIONS, MONSIEUR.\" \"", "IT IS NOW MY TURN TO LEAVE YOU WITH A MYSTERY,\" \"UNTIL THE DAY I EXPLAIN MYSELF TO YOUR SON.\" \"[", "DOOR OPENS]\" \"MONSIEUR LE COMTE, MAY I PRESENT ALBERT MONDEGO.\" \"", "MONSIEUR.\" \"", "IT IS A GREAT HONOR.\" \"", "YOU HONOR ME, MONSIEUR.\" \"", "ALL PARIS SPEAKS OF YOU, MONSIEUR.\" \"", "GOOD MORNING, MONSIEUR.\" \"", "ALL PARIS YEARNS TO SHAKE THE HAND OF\" \"THE MYSTERIOUS STRANGER.\" \"", "AND HERE YOU ARE SHAKING THAT HAND STRAIGHT FROM HIS ARM.\" \"", "THE CITY'S ON FIRE, MONSIEUR, WITH TALK, TALK, TALK, ABOUT\" \"THE COUNT OF MONTE CRISTO.\" \"", "NOW CONTROL YOURSELF.\" \"", "MY FATHER, MONSIEUR, EVEN MY FATHER'S CAUGHT UP IN THE GAME.\" \"", "UM...\" \"HE SAYS YOU'RE AN ORIENTAL.\" \"", "BUT HE SAYS HE MET YOU IN TURKEY.\" \"", "BECAUSE..\" \"UM..\" \"BECAUSE MY FATHER WAS AMBASSADOR TO THE KING OF VENIR.\" \"", "UH..\" \"SURELY YOU HAVE HEARD OF MY FATHER?\" \"", "THE COUNT MONDEGO.\" \"", "WHO HAS NOT HEARD OF THE GREAT GENERAL, FERNAND MONDEGO?\" \"", "A MAN I'VE ALWAYS WANTED TO MEET.\" \"", "MY DEAR COUNT, I'M THE FATHER OF ALBERT.\" \"", "GENERAL.\" \"", "MY SON ASTONISHES ME.\" \"", "I HAD NOT IDEA HE HAD\" \"REACHED SO HIGH IN THE SOCIAL SCALE.\" \"", "IT IS I WHO AM SCALING THE HEIGHTS, MONSIEUR.\" \"", "WHO HAS NOT HEARD OF THE GREAT EXPLOITS\" \"ON THE BATTLEFIELD OF GENERAL MONDEGO?\" \"", "MY DEAR COUNT.\" \"", "MONSIEUR LE COMPTE, MAY I PRESENT MY MOTHER, THE COUNTESS MONDEGO.\" \"", "OH, MONSIEUR, MY SON IS STILL A CHILD WHO PLAYS CHILDISH GAMES.\" \"", "HE TELLS ME WE HAVE A VISITOR AND HE REFUSES TO GIVE ME HIS NAME.\" \"", "HE SAYS I SHOULD BE DELIGHTFULLY SURPRISED.\" \"", "WE HAVE NOT MET BEFORE, HAVE WE, MONSIEUR?\" \"", "WHO DO I HAVE THE HONOR OF ADDRESSING, MONSIEUR.\" \"", "YOUR SERVANT, MADAME.\" \"", "THE COUNT OF MONTE CRISTO.\" \"", "YOU SAW HER?\" \"", "SHE KNEW YOU?\" \"", "SHE THINKS SHE KNOWS ME.\" \"", "BUT SHE REFUSES TO BELIEVE WHAT SHE THINKS.\" \"", "AND WHEN SHE DOES BELIEVE IT?\" \"", "IT WILL BE TOO LATE, PRINCESS.\" \"", "WE SHALL MOVE LIKE THE SWORD OF THE LORD,\" \"WITH A TERRIBLE SWIFTNESS.\" \"", "DO YOU LOVE HER, STILL?\" \"", "NO.\" \"", "SHE CANNOT INFLUENCE YOU?\" \"", "SHE CANNOT DISSUADE YOU?\" \"", "ANSWER ME, PLEASE.\" \"", "NO POWER IN HEAVEN OR EARTH CAN DISSUADE ME.\" \"", "NO ANGEL, NO DEMON, COULD KEEP ME FROM MY REVENGE.\" \"", "GOOD, MY LORD, GOOD.\" \"", "REMEMBER, YOUR REVENGE IS MY REVENGE.\" \"", "ALLEVO MONDEGO PAPERS.\" \"", "VILLEFORT.\" \"", "WE HAVE ONLY TO HEAR FROM THE DOCTOR.\" \"", "DANGLERS.\" \"", "WE HAVE ALL THE DOCUMENTS, MASTER.\" \"", "GOOD.\" \"", "THE PUBLIC SEES VILLEFORT AS THE LOVING FATHER,\" \"DEVOTED SON, THE FAITHFUL WATCHDOG OF THE LAW.\" \"", "DANGLERS, IS THE FINANCIAL WIZARD.\" \"", "ADVISOR TO GREAT\" \"FORTUNES, THE LION WHO GUARDS THE NATION'S WEALTH.\" \"", "MONDEGO IS THE GREAT WAR HERO.\" \"", "FAVORITE OF THE BOULEVARDS.\" \"", "AFFECTIONATELY CALLED THE PEACOCK FOR HIS MANY DECORATIONS.\" \"", "WELL, WE KNOW VILLEFORT IS A WOLF, DANGLERS A PIG, MANDEGO A HYENA,\" \"AND WE'RE FINALLY READY TO GO HUNTING.\" \"", "GOOD, VERY GOOD.\" \"", "THE WRIST, THE WRIST.\" \"", "GOOD, VERY GOOD.\" \"", "YOU ARE THE MASTER, NOW.\" \"", "I AM THE PUPIL.\" \"", "PUT IT BACK.\" \"", "WE'VE HAD A DEVIL OF A TIME FINDING YOU.\" \"", "PEOPLE USUALLY DO.\" \"", "SIX YEARS AGO, YOU WERE SENTENCED TO THE GALLEYS\" \"THE CHARGE WAS SMUGGLING.\" \"", "ESCAPED FROM THE GALLEYS.\" \"", "CAUGHT.\" \"", "SENTENCED TO LIFE IN THE GALLEYS.\" \"", "YOU ESCAPED AGAIN.\" \"", "READ ON.\" \"", "I FIND MYSELF FASCINATING.\" \"", "YOU'VE BEEN A THIEF, SMUGGLER, EMBEZZLER, POSSIBLY AN ASSASSIN,\" \"DURING THE COURSE OF WHICH YOU'VE LEARNED TO SPEAK FLUENT ITALIAN.\" \"", "PERFECTO, SEIGNEUR.\" \"", "FROM NOW ON YOU ARE ANDREA, THE COUNT OF CAVALCANTE.\" \"", "AM I?\" \"", "YOU ARE THE SON OF MAJOR BARTOLOMEO DE CAVALCANTE,\" \"A DESCENDENT OF THE CAVALCANTE WHOSE NAMES ARE INSCRIBED\" \"IN THE GOLDEN BOOK OF FLORENCE.\" \"", "YOU ARE VERY RICH.\" \"", "GOOD!\" \"", "I SPEND A LOT OF MONEY, OF COURSE.\" \"", "OF COURSE.\" \"", "YOU WILL TAKE APARTMENTS, WHICH I HAVE SELECTED FOR YOU\" \"ON THE FAUBORG.\" \"", "YOU WILL HAVE THREE SERVANTS.\" \"", "YOU WILL PURCHASE A CARRIAGE.\" \"", "GO TO BATISTE FOR IT.\" \"", "THE HORSE IS FROM DEBIDEUX.\" \"", "YOU WILL PAY COURT TO A BEAUTIFUL YOUNG GIRL.\" \"", "I WISH YOU TO DO IT EXPENSIVELY.\" \"", "FOR THE NEXT FEW WEEKS, WHEN YOU ARE NOT WITH HER,\" \"YOU WILL BE SEEN EVERYWHERE WITH ME.\" \"", "AH, THE COUNT ACCOMPANIES THE COUNT.\" \"[", "CHUCKLING]\" \"PRECISELY.\" \"", "NOW, WHAT IS YOUR NAME?\" \"", "THE COUNT OF CAVALCANTE.\" \"", "THE COUNT OF MONTE CRISTO.\" \"", "SO GLAD YOU COULD COME.\" \"", "IT IS A PLEASURE TO SEE YOU, DEAR COUNT.\" \"", "MAY I PRESENT MY FRIEND, THE COUNT OF CAVALCANTE,\" \"WHOM YOU WERE GRACIOUS ENOUGH TO INCLUDE IN YOUR INVITATION.\" \"", "ANY FRIEND OF MONTE CRISTO.\" \"", "MAY I PRESENT MY DAUGHTER, VALENTINE.\" \"", "MADEMOISELLE.\" \"", "MONSIEUR LE COMPTE.\" \"", "CAVALCANTE'S IN PARIS ON FAMILY BUSINESS.\" \"", "AND LEAVE HIS WIFE IN ITALY?\" \"", "HE'S UNMARRIED.\" \"", "OH.\" \"", "HAVE YOU KNOWN HIM LONG?\" \"", "BUT A FEW DAYS.\" \"", "HE CAME TO ME WITH LETTERS OF\" \"INTRODUCTION FROM MY BROKERS IN ROME.\" \"", "I KNOW HIS FAMILY, OF COURSE.\" \"", "ALL OF ITALY KNOWS THE CAVALCANTE,\" \"WHO WERE RICH WHEN THE MEDICI WERE PEASANT STOCK.\" \"...", "SIGNORINA, I WOULD BE DEEPLY GRATEFUL...\" \"YOUR DAUGHTER'S FIANCÉ DOES NOT TAKE EXCEPTION?\" \"", "BUT, MY DAUGHTER HAS NO FIANCÉ.\" \"", "SHE'S NOT ENGAGED TO ALBERT MONDEGO?\" \"", "NOT AT ALL.\" \"", "NOT AT ALL.\" \"", "THEY ARE ONLY FRIENDS.\" \"[", "DOOR OPENS]\" \"MY DEAR COUNT.\" \"", "M. DANGLARS, I WISH TO PURCHASE A NEWSPAPER, LE JOURNAL DE GLOBE,\" \"I AM TOLD IT'S FOR SALE.\" \"", "I RATHER FANCY OWNING A NEWSPAPER.\" \"", "PLEASE ARRANGE FOR ITS PURCHASE.\" \"", "VERY GOOD, I APPROVE, EVERY MAN OF AFFAIRS\" \"SHOULD OWN A NEWSPAPER.\" \"", "SECOND, I WISH TO BUY SOME SPANISH GOVERNMENT BONDS.\" \"", "IN WHAT AMOUNT OF PURCHASE, SIR?\" \"", "ONE MILLION.\" \"", "I...\" \"IN...\" \"UH...\" \"SPANISH BONDS?\" \"", "CAN THE PURCHASE BE EFFECTED IMMEDIATELY?\" \"", "EH, IMMEDIATELY, SIR.\" \"", "AND CONFIDENTIALLY.\" \"", "WITH THE UTMOST DISCRETION.\" \"", "IT WOULD NOT BE WISE FOR ANYONE TO FOLLOW\" \"MY LEAD IN THE MARKET.\" \"", "I'M A GAMBLER, NOT AN INVESTOR.\" \"", "GOOD DAY, BARON, TOMORROW I LEAVE FOR LONDON ON BUSINESS.\" \"", "GIVE MY REGARDS TO THAT FASCINATING CITY.\" \"", "THOUGH THE ENGLISH WILL NEVER LEARN HOW TO EAT.\" \" ", "THERE ARE PLACES.\" \"", "AS YOU AND I KNOW, MY DEAR, BARON.\" \"", "MONEY CAN BUY ANYTHING.\" \"", "ANYTHING.\" \" ", "GIRARD!\" \"", "GIRARD!\" \"", "MAKE OUT AN ORDER FOR A MILLION IN SPANISH BONDS\" \"FOR THE COUNT OF MONTE CRISTO.\" \"", "SPANISH?\" \"", "AND FOR MYSELF ONE MILLION.\" \"", "FOR MY PRIVATE ACCOUNT.\" \"", "BARON, SPANISH BONDS...\" \"WHEN MONTE CRISTO BUYS, I BUY.\" \"", "HAVE YOU FORGOTTEN\" \"THE RESULT WHEN WE FOLLOWED HIS LEAD THE LAST TIME?\" \"", "DOES HE KNOW THAT YOU...\" \"CONTACT OUR MOST IMPORTANT PORTFOLIO, SIR, INFORM THEM\" \"DE LIVIER, AND...\" \"UH..\" \"BEAUFORT, THAT THE HOUSE\" \"OF DANGLARS RECOMMENDS HEAVY INVESTMENT IN SPANISH BONDS.\" \"", "WELL, DO IT!\" \" ", "NOW!\" \"[", "TOASTING] THE COUNT OF MONTE CRISTO.\" \"", "IS THIS YOUR SEMAPHORE STATION?\" \"", "MINE?\" \"", "I WORK IT.\" \"", "I'VE DONE FOR MANY YEARS,\" \"BUT I NEVER HAVE ANY VISITORS.\" \"", "HOW DOES IT WORK?\" \"", "THERE'S ANOTHER ONE ON THE FAR HORIZON.\" \"", "THAT'S MY RIGHT-HAND CORRESPONDENT.\" \"", "AND THERE IS MY LEFT HAND.\" \"", "WHEN I RECEIVE A MESSAGE, FROM RIGHT I TRANSMIT IT TO LEFT.\" \"", "THUS, OUR MESSAGES FROM SPAIN TRANSMITTED ALL THE WAY\" \"TO PARIS IN A MATTER OF HOURS.\" \"", "A MODERN MIRACLE.\" \"", "THREE THOUSAND FRANCS, FIVE YEARS PAY, IF YOU RELAY\" \"THIS MESSAGE TO PARIS.\" \"", "BUT...\" \"THIS IS...\" \"NOT OFFICIAL.\" \"", "YOU INSULT ME, SIR.\" \"", "IT IS AN INSULT.\" \"", "IMPOSSIBLE.\" \"", "IT IS THE OFFICIAL TELEGRAPH SERVICE, SIR.\" \"", "KING DON CARLOS HAS INVADED SPAIN THROUGH\" \"THE CATALONIAN FRONTIER.\" \"", "CIVIL WAR IS IN FORCE!\" \"", "CIVIL WAR!\" \"", "WHAT WILL HAPPEN TO SPANISH BONDS?\" \"", "IF I MAY SUGGEST IT, SIR.\" \"", "SUGGEST!\" \"", "SUGGEST!\" \"", "A QUICK SELL-OUT, THE QUICKER THE BETTER.\" \"", "THAT'S IT.\" \"", "YES.\" \"", "SELL EVERY BOND, NOW!\" \"", "THE MOMENT THE EXCHANGE OPENS, SIR.\" \"", "MY REPUTATION, THE REPUTATION OF MY BANK!\" \"", "I INVEST MY CLIENTS MONEY IN CIVIL WARS AND CATACLYSMS!\" \"", "I'LL NOT HAVE A CLIENT LEFT TOMORROW.\" \"", "YOU HAVE ANOTHER SUGGESTION, HAVE YOU?\" \"", "YES, MAKE GOOD ALL LOSSES.\" \"", "YES.\" \"", "FROM THE BANKS RESERVES.\" \"", "FROM YOUR OWN.\" \"", "YOU'RE INSANE.\" \"", "I CAN PLACE THE ORDER TO SELL NOW, MONSIEUR.\" \"", "WHAT IS IT YOU WANT OF ME?\" \"", "A LITTLE OF YOUR TIME, FOR WHICH YOU'LL BE PAID.\" \"", "I AM YOUR SERVANT, SIR.\" \"", "YOU NAME IS CADEROUSSE.\" \"", "IT IS MY REAL NAME.\" \"", "HOW DID YOU KNOW?\" \"", "YOU SPENT SEVEN YEARS OF YOUR LIFE IN HIS\" \"MAJESTY'S GALLEYS.\" \"", "YOU MADE ONE ATTEMPT TO ESCAPE.\" \"", "YES.\" \"", "AND IF IT WERE NOT FOR\" \" A CERTAIN PERSON...\" \" YOU HAD A COMPANION\" \"IN YOUR ESCAPE.\" \"", "HE PLAYED YOU FALSE.\" \"", "FAUSTINO.\" \"", "MY LIFE IS DEDICATED TO ONE PURPOSE,\" \"FIND HIM, AND KILL HIM!\" \"", "REVENGE IS A SWEET THING TO LIVE FOR,\" \"OR DIE FOR.\" \"", "SIR, I HAVE OTHER PRESSING BUSINESS, WHICH SHOULD TAKE ONLY A MOMENT.\" \"", "WOULD IT INCONTINENCE YOU TO WAIT OUTSIDE?\" \"", "I AM YOU SERVANT, SIR.\" \" ", "MONSIEUR.\" \" ", "MONSIEUR.\" \"", "FAUSTINO!\" \"", "FAUSTINO, GOD IS SOMETIMES GOOD.\" \"", "FROM WHAT BLACK HOLE IN HELL, DID YOU COME BACK TO LIFE?\" \"", "FROM THE CUL-DE-SAC IN WHICH YOU LET ME DIE.\" \"[", "CRASH]\" \"[THUD]\" \"[THUD] OH!\" \"", "OH!\" \"[", "THUD]\" \"AW!\" \"", "DID YOU SEE?\" \"", "HE ATTACKED ME.\" \"", "WHAT COULD I DO?\" \"", "TAKE HIM TO THE POLICE.\" \"", "YOU KNOW THIS MAN?\" \"", "WHO ARE YOU, MONTE CRISTO?\" \"", "WHO ARE YOU?\" \"", "TAKE HIM AWAY.\" \"", "ONE.\" \"[", "SLAP] HE IS NOT OF THE HOUSE OF CAVALCANTE!\" \" ", "HIS NAME IS BENEDETTO.\" \"", "HIS MOST RECENT NAME, THAT IS.\" \" ", "HE IS A NOTORIOUS ESCAPED CRIMINAL.\" \"", "AND HE WANTS TO MARRY MY DAUGHTER.\" \"", "HE DOESN'T LACK NERVE, I MUST SAY.\" \"", "HE IS AN ESCAPED GALLEY SLAVE,\" \"AMONG OTHER OFFENCES.\" \"", "DUPED!\" \"", "HE HAS DUPED US ALL, SERGEANT\" \"INCLUDING THE INFALLIBLE MONTE CRISTO.\" \"", "A CAVALCANTE INDEED.\" \"", "THIS UPSTART, THIS RABBIT.\" \"", "HE HAS INSULTED MY VERY PERSON, WHICH COMPELS ME TO PROSECUTE\" \"THIS CASE MYSELF.\" \"", "IN FACT, IT BECOMES A MORAL DUTY.\" \"[", "UNLOCKING AND OPENING A JAIL DOOR]\" \"LAST RITES, HUH?\" \"", "I HAVE NOT BEEN TRIED, YET.\" \"", "PLEASE, GO AWAY.\" \"", "ANDREA DE CAVALCANTE?\" \"", "GO AWAY.\" \"", "FAUSTINO.\" \"", "YOU?\" \"", "MY BLESSED PROTECTOR.\" \"", "WILL YOU PROTECT ME\" \"FROM THE GUILLOTINE, HUH?\" \"", "YOU WON'T BE CONVICTED IF YOU DO AS I SAY.\" \"", "MEMORIZE THE FIRST PAGE ENTIRELY.\" \"", "FAMILIARIZE YOURSELF WITH ALL THE OTHER DOCUMENTS.\" \"", "I WILL BE IN THE COURTROOM.\" \"", "KEEP YOUR EYES ON ME.\" \"", "SO THIS MAN, ANDREA BENEDETTO, FAUSTINO,\" \"HE ASSUMES A NEW NAME FOR EACH FRESH TRANSGRESSION,\" \" IS NO SIMPLE RASCAL, NO PETTY SCOUNDREL.\" \" ", "HE IS A SERPENT OF SUBTLETY.\" \"", "A GIANT OF CUNNING.\" \"", "BUT NOW, THIS MURDERER, HAS BEEN CAUGHT IN THE ACT,\" \"WITH THE WEAPON IN HIS HAND.\" \"", "GLOATING OVER THE FALLEN BODY OF HIS VICTIM.\" \"", "SO YOU CAN PASS ONLY ONE VERDICT ON THE DISPOSITION\" \"OF THIS MISERABLE CREATURE.\" \"", "DEATH!\" \"[", "APPLAUSE]\" \"[GAVEL SOUNDING]\" \"ORDER IN THE COURT.\" \"", "ORDER.\" \"", "ORDER.\" \"", "ACCUSED, RISE.\" \"", "ACCUSED, YOUR NAME AND SURNAME.\" \"", "MONSIEUR LE PRESIDENT, I WILL GIVE MY NAME LAST OF ALL.\" \"", "LET'S PROCEED.\" \"[", "GAVEL KNOCKING]\" \" YOUR AGE.\" \"", "I AM 21 YEARS OLD.\" \"", "I WAS BORN ON THE NIGHT OF THE 27TH OF SEPTEMBER, 1817.\" \" ", "WHERE WERE YOU BORN?\" \"", "AT AUTOREILLE, NEAR PARIS.\" \" ", "YOUR VOCATION?\" \"", "OH, I AM A PROFESSIONAL MAN,\" \"A FORGER, THIEF, ON OCCASION AN ASSASSIN.\" \" ", "HAVE YOU A REQUEST, MONSIEUR DE VILLEFORT?\" \" ", "QUESTIONS FROM THE\" \" BENCH HAVE BEEN COMPLETED.\" \" ", "ALL BUT ONE.\" \" ", "NOW, PRISONER, NOW.\" \"", "WILL YOU CONSENT\" \" TO SAY YOUR NAME?\" \" ", "YOUR TRUE NAME.\" \"", "I DO NOT KNOW IT.\" \"", "BUT I KNOW MY FATHER'S NAME.\" \" ", "THEN REPEAT YOUR FATHER'S NAME.\" \"", "MY FATHER IS THE KING'S PROSECUTOR.\" \"[", "MURMUR FROM THE COURTROOM]\" \" WHAT DID YOU SAY?\" \"", "HIS NAME IS DE VILLEFORT.\" \"[", "CROWD MURMUR]\" \"ORDER, ORDER.\" \"[", "GAVEL KNOCKING]\" \"SILENCE.\" \"", "SILENCE.\" \"", "IN THE YEAR, 1817, M. DE VILLEFORT RENTED A HOUSE,\" \"AT 28, RUE DE LA FONTAINE IN THE VILLAGE OF AUTEUILLE.\" \"", "HIS PURPOSE, TO KEEP THERE, HIDDEN FROM POLITE SOCIETY,\" \"A YOUNG WOMAN.\" \"", "AFTER A YEAR OF SECRET RESIDENCE IN AUTEUILLE.\" \"", "THE YOUNG WOMAN, TO VILLEFORT'S EXASPERATION\" \"GAVE BIRTH TO AN INFANT SON.\" \"", "HOURS AFTER THE BIRTH, THE MOTHER DIED.\" \"", "THAT VERY NIGHT, VILLEFORT TOOK THE SON, WRAPPED\" \"IT IN A CLOTH AND BURIED IT ALIVE\" \"IN THE GARDEN OF THE HOUSE.\" \"", "THE BURIAL, M. LE PRESIDENT, WAS WITNESSED\" \"FROM AN UPPER WINDOW OF THE HOUSE BY A SERVANT.\" \"", "IT WAS HE WHO DISINTERRED THE BODY, DISCOVERING IT WAS\" \"STILL ALIVE.\" \"", "HE FOUGHT WITH CADMILLE TO A FOUNDLING HOME. (?\" \")\" \"", "AT THE AGE OF 13, I RAN AWAY FROM THE HOME,\" \"AND EMBARKED UPON THE DISTINGUISHED CAREER\" \"WHICH HAS FINALLY BROUGHT ME, M. LE PRESIDENT, TO THIS COURT.\" \"[", "TAP, TAP, TAP]\" \"THE LEASE ON THE HOUSE IN THE FEUER, SIGNED BY M. DE VILLEFORT.\" \"", "THE DEATH CERTIFICATE OF THE MADEMOISELLE OF THE LEAGUE OF COURS\" \"SIGNED BY THE POLITORI OF AUTEUILLE\" \"A CERTIFICATE FROM THE SAME DOCTOR TESTIFYING THAT M. DE VILLEFORT\" \"WAS THE FATHER OF THE CHILD.\" \"", "THE PHYSICIANS, TESTAMENTS COURT STATEMENTS, ETC., ", "ETC., ", "ETC.,....\" \"", "TWO\" \"IN THIS MORNING'S PAPER.\" \"", "IT MIGHT BE ADVISABLE, SIR.\" \"", "NO.\" \" ", "WHAT IS IT THERE?\" \"", "NO.\" \"", "NO.\" \"", "NO.\" \"", "NO.\" \"", "NO.\" \"", "NO.\" \"", "NO!\" \"", "LISTEN, MONSIEUR, I...\" \"IT IS WITHOUT FOUNDATION\" \"THAT THE JOURNAL DE GLOBE YESTERDAY ANNOUNCED A REVOLT IN SPAIN.\" \"", "A TELEGRAPHIC SIGNAL, IMPROPERLY INTERPRETED,\" \"OWING TO THE FOG, WAS THE CAUSE OF THIS ERROR.\" \"", "THERE WAS NO INVASION.\" \"", "THERE IS NO WAR.\" \"", "SPAIN...\" \"IS AT PEACE!\" \"[", "DOOR OPENS]\" \"DANGLARS, AH, YOU HAVE SEEN THE PAPER.\" \"", "YOU KNOW WHAT'S HAPPENING.\" \"", "IS THAT WHY YOU SO MAGNANIMOUSLY\" \"MADE GOOD OUR LOSSES?\" \"", "SO YOU COULD BUY UP OUR BONDS.\" \"", "BUT, GENTLEMEN, I'VE SOLD MY BONDS, TOO.\" \"", "I SWEAR IT!\" \" ", "YOU LIE.\" \" ", "I DON'T BELIEVE YOU, DANGLARS.\" \"", "DANGLARS, DO YOU KNOW WHAT YOU HAVE COST ME?\" \"", "YOU'VE READ THE PAPER, HAVEN'T YOU?\" \"", "BUT, GENTLEMEN, YOU'VE LOST NOTHING...\" \"I LOSE WHEN I DO NOT MAKE.\" \"", "I WANT TO KNOW WHAT THIS IS ALL ABOUT.\" \"", "I'VE MADE GOOD EVERY PENNY.\" \"", "I DEMAND TO KNOW.\" \" ", "I WILL TAKE THE MATTER UP WITH THE CHAMBER.\" \" ", "THE BONDS ON GOVERNMENTS.\" \" ", "CONFESS, DANGLARS.\" \"", "CONFESS, YOU ARE A SCOUNDREL.\" \" ", "BE ADVISED, DANGLARS.\" \" ", "I AM TAKING YOU TO COURT.\" \" ", "AFTER ME, I AM TAKING HIM TO COURT, FIRST.\" \" ", "NO, AFTER ME.\" \"", "ON CHARGES OF FALSE REPRESENTATION.\" \" ", "MISUSING OF FUNDS!\" \"", "EMBEZZLEMENT.\" \" ", "I BEGIN BY WITHDRAWING MY ACCOUNT FROM THIS BANK.\" \" ", "YES, SO WILL I, BEFORE THE RUN BEGINS.\" \"", "THE RUN!\" \" ", "IF YOU CAN'T TRUST THE BIGGEST BANKER IN PARIS...\" \"I SHALL GO NOW...\" \"[INDISTINCT CHATTER]\" \"[NERVOUS LAUGHTER]\" \"[GUNSHOT]\" \"[THUD].\" \"", "THREE.\" \"", "ALBERT.\" \"", "WHAT A PLEASANT SURPRISE, ALBERT.\" \"", "I'M NOT HERE TO EXCHANGE HYPOCRITICAL EXPRESSIONS\" \"OF POLITENESS,\" \"BUT TO DEMAND AN EXPLANATION.\" \"", "FOR WHAT, MY DEAR BOY.\" \"", "OH, I SPOTTED A STORY IN THE PAPER THIS MORNING.\" \"", "THE ONE CASTING TERRIBLE ASPERSIONS ON MY FATHER.\" \"", "ON HIS INTEGRITY.\" \"", "ON HIS MILITARY ACCOMPLISHMENTS.\" \"", "ON HIS HONOR!\" \"", "YES.\" \"", "AND IT'S IN THE JOURNAL DE GLOBE.\" \"", "THE NEWSPAPER YOU SO RECENTLY PURCHASED.\" \"", "YOU ARE IN MY HOME, ALBERT.\" \"", "I, ALONE, HAVE THE RIGHT TO RAISE MY VOICE HERE.\" \"", "YOU'RE RESPONSIBLE FOR THAT STORY.\" \"", "DO YOU DENY IT?\" \"", "NO.\" \"", "I CONSIDER THE GLOVE THROWN, ALBERT.\" \"", "TOMORROW MORNING, SIR.\" \"", "FIELD OF MARS AT DAWN.\" \"", "THE FIELD OF MARS.\" \"[", "BREATHLESS] WHY?\" \"[", "GUNSHOT]\" \"[GUNSHOT]\" \" YOU WOULD NOT KILL MY SON.\" \"", "HE CHALLENGED ME, MADAME.\" \"", "AND WHAT WOULD YOU EXPECT FROM A PROUD SON?\" \"", "THE GENERAL IS HIS FATHER.\" \"", "I HAD A FATHER, ONCE.\" \"", "THEN YOU KNOW HOW THE BOY FEELS.\" \"", "YOU CAN UNDERSTAND HOW ZEALOUS HE IS AFTER THE GENERAL'S GOOD NAME.\" \"", "WHAT GENERAL?\" \"", "MY BUSINESS IS WITH A LIEUTENANT I USED TO KNOW.\" \"", "WHAT BUSINESS?\" \"", "REVENGE, MADAME.\" \"", "FOR WHAT?\" \"", "A MAN EVEN GOING IN LOVE.\" \"", "HE DOES NOT DESERVE YOUR VENGEANCE.\" \"", "IT WAS I. I WAS WEAK.\" \"", "I COULD BEAR MY LONELINESS NO LONGER.\" \"", "I MARRIED HIM BECAUSE THEY TOLD ME YOU DIED IN THE CHATEAU\" \"D'IF SHORTLY AFTER YOUR ARREST.\" \"", "BUT WHY WAS I IN THE CHATEAU D'IF?\" \"", "WHY WAS I ARRESTED?\" \"", "I DO NOT KNOW.\" \"", "I PRESUME YOU RECOGNIZE THE HAND?\" \"", "HOW DID YOU COME BY THIS?\" \"", "WITH BRIBERY, MADAME.\" \"", "I CANNOT BELIEVE...\" \"FOR 14 YEARS, BECAUSE OF THAT LETTER,\" \"I LIVED IN THE DUNGEON OF THE CHATEAU D'IF,\" \"SO NEAR TO YOU, AND I NEVER KNEW THAT YOU'D MARRIED,\" \"OR THAT MY FATHER HAD DIED,\" \"OF HUNGER.\" \"[", "WHISPER] HUNGER!\" \"", "OH, I DID NOT KNOW.\" \"", "WE HAD MOVED AWAY.\" \"", "ASK ME TO FORGIVE A MAN FOR STEALING MY LOVE\" \"WITH A LOVER'S DECEPTION,\" \"VERY WELL, SINCE YOU ASK IT, I FORGIVE HIM THAT.\" \"", "ASK ME TO FORGIVE HIM FOR STEALING 14 YEARS OF MY LIFE.\" \"", "VERY WELL, FORGIVEN.\" \"", "BUT FORGIVE HIM FOR DESTROYING MY FATHER.\" \"", "NEVER, MADAME.\" \"", "NEVER!\" \"", "IN MY DREAMS I HAVE SEEN YOU DEAD.\" \"", "THROWN TO THE BOTTOM OF ONE OF THOSE PITS\" \"WHERE JAILERS THROW THEIR DEAD PRISONERS.\" \"", "AND I AWAKE FROM THIS INCESSANT DREAM WITH A CRY,\" \"SHUDDERING COLD.\" \"", "HAVE YOU EVER DREAMED YOUR FATHER DEAD OF HUNGER?\" \"", "HAVE YOU EVER DREAMED OF THE ONE YOU LOVED\" \"GIVING HER HAND TO A RIVAL,\" \"WHILE YOU PERISH AT THE BOTTOM OF A PIT.\" \"", "WHAT!\" \"", "I HAVE SEEN HIM I LOVED ON THE POINT OF MURDERING MY SON.\" \"", "OH, EDMOND, PLEASE.\" \"", "WHAT GOOD HAS IT DONE FOR ME TO MOURN FOR YOU\" \"ETERNALLY IN THE SECRET RECESSES OF MY HEART?\" \"", "WHEN I THOUGHT YOU DEAD, I SHOULD HAVE DIED, TOO.\" \"", "BUT FOOLISHLY I WENT ON LIVING, AND FOR NEARLY 20 YEARS\" \"COMPARED ALL MEN TO YOU AND FOUND THEM WANTING.\" \"", "MISSING YOU HAS BEEN A DAY AFTER DAY, YEAR AFTER YEAR\" \"TORMENT TO ME.\" \"", "AND IN ALL THIS TIME MY ONE CONSOLATION HAS BEEN MY SON.\" \"", "MY INNOCENT SON WHO SHOULD HAVE BEEN OURS.\" \"", "OUR SON, EDMOND.\" \"", "READY.\" \"", "1, 2, 3, 4, 5, 6, 7, 8, 9, 10\" \"[GUNSHOT]\" \"[GUNSHOT]\" \"SHE TOLD YOU.\" \"", "EVERYTHING.\" \"", "I OFFER YOU MY APOLOGIES, SIR.\" \"", "YOU HAVE EVERY RIGHT TO EXPOSE MY FATHER.\" \"", "PROVIDENCE, AGAIN.\" \"", "I AM THE EMISSARY OF GOD.\" \"", "I'VE BEEN SPARED TO CARRY OUT HIS WILL.\" \"", "GENERAL MONDEGO,\" \"THIS SPECIAL COMMITTEE OF THE HOUSE OF DEPUTIES\" \"IS WELL AWARE OF YOUR ILLUSTRIOUS PAST.\" \" ", "WE SALUTE, WITH PROFOUND RESPECT, THE DECORATIONS\" \" YOU BEAR AS TESTAMENT TO YOUR EXTRAORDINARY MILITARY CAREER.\" \" ", "IT IS THEN A GREAT DISTURBANCE TO THIS COMMITTEE TO READ THE\" \" REVELATIONS IN THE NEWS PAPER, LE JOURNAL DE GLOBE.\" \" ", "STARTING YESTERDAY WITH A THREAT OF DISCLOSURES, LE JOURNAL DE GLOBE\" \" CONTINUES TODAY WITH A LONG LIST OF DEFINITE ACCUSATIONS.\" \"", "IT IS WRITTEN HERE, IN THE GREEK WAR WHEN YOU WERE\" \"FRENCH EMISSARY TO COURT OF ALI PASHA,\" \"THAT YOU BETRAYED HIM TO THE TURKS.\" \" ", "IT IS WRITTEN HERE...\" \" M. LE PRESIDENT,\" \"MAY I PROCEED IMMEDIATELY TO MY OWN DEFENSE?\" \"", "PROCEED, MONSIEUR.\" \"", "DOCUMENT.\" \"", "A SIGNED LETTER FROM THE ALI PASHA, HIMSELF, PROPOSING\" \"THE EXPRESSIONS OF THE UTMOST CONFIDENCE.\" \"", "SO COMPLETE WAS HIS FAITH IN ME, THAT ON HIS DEATHBED\" \"HE RESIGNED HIS WIFE AND DAUGHTER TO MY CARE.\" \"", "HIS WIFE AND DAUGHTER.\" \"", "WHAT HAPPENED TO THAT WIFE AND DAUGHTER?\" \"", "I SEARCHED FOR THEM, M. LE PRESIDENT, IN THE\" \"MIDST OF THE BATTLE.\" \"", "MY LIFE WAS IN CONSTANT DANGER,\" \"BUT I SEARCHED FOR THEM UNTIL I FOUND THEM.\" \"", "THEY HAD BEEN SLAUGHTERED BY THE ENEMY.\" \"", "CAN YOU PRODUCE TESTAMENTS TO THE TRUTH OF WHAT YOU HAVE ASSERTED?\" \"", "MONSIEUR LE PRESIDENT, IF THE SIGNED PROOF OF ALI PASHA IS NOT ENOUGH,\" \"I OFFER MY WORD OF HONOR AS A FRENCH OFFICER.\" \"", "LAST, BUT NOT LEAST, THIS.\" \"", "YOU ASK FOR WITNESSES OF PROOF, I ASK FOR A SHOW\" \"OF WITNESSES AGAINST ME.\" \"", "WHAT IS THE EVIDENCE?\" \"", "SOME ARTICLE IN A SCURRILOUS JOURNAL.\" \"", "WHO GAVE THESE LIES TO THIS NEWSPAPER?\" \"", "WHERE IS HE?\" \"", "LET HIM COME FORWARD,\" \"AND THROW A GLOVE IN MY FACE!\" \"[", "APPLAUSE]\" \"MONSIEUR LE COMPTE, YOUR DEFENSE HAS THE RING OF VALIDITY,\" \"YOUR POINTS WELL TAKEN.\" \"", "YOU WILL THEREFORE BE GRATIFIED TO LEARN\" \"THE CONTENTS OF THIS NOTE I HAVE JUST RECEIVED.\" \"", "AS FOLLOWS:\" \"I WAS PRESENT AT THE DEATH OF ALI PASHA.\" \"", "I KNOW WHAT HAS BECOME OF THE WIFE AND THE DAUGHTER.\" \"", "I CLAIM THE HONOR OF BEING HEARD.\" \"", "WHO WROTE THOSE WORDS?\" \"", "THE NOTE IS UNSIGNED, SIR, BUT THE WITNESS CAN BE\" \"SUMMONED ON YOUR APPROVAL.\" \"", "ONLY ON YOUR APPROVAL.\" \"", "LET HIM APPEAR.\" \"", "LET HIM APPEAR.\" \"", "WILL YOU IDENTIFY YOURSELF, PLEASE?\" \"", "I AM THE DAUGHTER OF ALI PASHA.\" \"", "IN FRONT OF YOU, SIR, IS A REGISTER OF MY\" \"BIRTH AND MY BAPTISM.\" \"", "THERE IS ALSO IN THAT PACKET A RECORD OF THE SALE OF MY\" \"PERSON AND THAT OF MY MOTHER.\" \"", "A SALE, YOU SAY?\" \"", "A FRENCH OFFICER SOLD US INTO SLAVERY FOR THE SUM\" \"OF 40,000 FRANCS.\" \"", "THE NAME OF THAT OFFICER.\" \"", "FERNAND MONDEGO.\" \"", "YOU WERE TRUSTED BY MY NOBLE FATHER.\" \"", "YOU WERE LOVED BY HIM AS A SON.\" \"", "HE HAD TRUSTED YOU WITH THE SAFE CONDUCT OF HIS\" \"WIFE AND DAUGHTER.\" \"", "BUT YOU'RE A LIAR.\" \"", "A TRAITOR.\" \"", "AN ASSASSIN.\" \"", "ASSASSIN!\" \"", "IT WAS YOUR SWORD THAT KILLED MY FATHER.\" \"", "MONSIEUR LE GENERAL, WILL YOU REPLY?\" \"", "LIES.\" \"", "LIES.\" \"", "THEY'RE LIES.\" \"", "YOU TAKE THE WORD OF AN INFIDEL FOREIGNER\" \"AGAINST THE WORD OF A GENERAL\" \"OF THE ARMY OF THE KING?\" \"", "THE WOMAN IS AN IMPOSTER!\" \"", "WHO IS AN IMPOSTER?\" \"", "SHE IS TRULY THE DAUGHTER OF ALI PASHA.\" \"", "THOSE DOCUMENTS WILL PROVE IT.\" \"", "THEY'LL VERIFY THEMSELVES SOON ENOUGH.\" \"", "AND WHEN THEY ARE VERIFIED, GENERAL MONDEGO,\" \"COUNT OF MONDEGO, HERO OF YANNINA,\" \"WHAT, WHAT IS YOUR CONNECTION WITH THIS WOMAN?\" \"", "ASK FIRST, WHAT IS MY CONNECTION WITH ONE\" \"NAMED EDMOND DANTES.\" \"[", "WHISPERING]:\" \"EDMOND.\" \"[", "LAUGHING QUIETLY]\" \"SO, THE LIGHT BEGINS TO BREAK.\" \"", "OLD SAILOR BOY.\" \"", "BACK FROM THE ISLE OF THE DEAD, HUH?\" \"", "HEH.\" \"", "INSISTING ON HIS REVENGE AND GETTING IT.\" \"", "I BEGIN TO SEE, YES.\" \"", "CADEROUSSE DEAD, DANGLARS DEAD, VILLEFORT CONFINED\" \"TO AN ASYLUM.\" \"", "IS IT MY TURN, EDMOND?\" \"", "IT IS.\" \"", "YOU'VE DONE EXCEEDINGLY WELL.\" \"", "THEY WAY YOU EXPOSE US ONE BY ONE.\" \"", "AND THEN YOU'LL STRIKE.\" \"[", "SCRAPING OF WITHDRAWING SWORD]\" \"YOU RUIN A MAN WITH EXQUISITE FINESSE.\" \"", "BUT, BEFORE YOU KICK THIS DOG TO DEATH, BEWARE.\" \"[", "GRABBING SWORD]\" \"HE BARKS.\" \"", "BARKS!\" \"[", "BOOMING SOUND OF THROWN SWORD SHEATH]\" \"BY HAVING RUINED ME YOU NOW GIVE ME CAUSE FOR REVENGE.\" \"", "I NOW CLAIM THE RIGHT TO SEND THE DEAD BACK TO THE DEAD.\" \"", "CAN YOU DEFEND YOURSELF, EDMOND?\" \"", "OR DO YOU STAB ONLY IN THE DARK?\" \"", "GENTLEMEN, GENTLEMEN, PLEASE!\" \"", "I BEG YOU, PLEASE LISTEN!\" \"[", "CALLS TO DESIST]\" \"DON'T SAY YOUR PRAYERS.\" \"", "YOU WON'T ESCAPE PRISON BY THE SIMPLE TRICK OF DYING.\" \"", "YOU'LL SERVE YOU SENTENCE IN THIS WORLD,\" \"BEFORE YOU GO TO HELL.\" \"", "GENERAL MONDAGO, YOU ARE UNDER ARREST.\" \"", "FOUR\" \"[DOOR OPENS]\" \"MERCEDES.\" \"", "MERCEDES!\" \"", "MERCEDES!\" \"[", "DOOR OPENS]\" \"WHY IS THE HOUSE EMPTY?\" \"", "WHERE IS THE COUNTESS MONDEGO?\" \"", "SHE HAS GONE TO MARSEILLE.\" \"", "WHEN?\" \"", "YESTERDAY.\" \"", "MERCEDES.\" \"", "WHERE ARE YOU TRAVELING?\" \"", "TO AFRICA, TO FIND MY SON AND BE NEAR HIM.\" \"", "HE'S JOINED THE ARMY.\" \"", "ALBERT, A SOLDIER?\" \"", "HE WANTS TO EXPIATE HIS FATHER'S SINS.\" \"", "LET ME JOIN YOU ON YOUR VOYAGE.\" \"", "I CAN BE OF HELP TO YOU BOTH.\" \"", "MY SON WOULD NEVER PERMIT THAT.\" \"", "WHAT YOU SAID, HE SHOULD HAVE BEEN OUR SON.\" \"", "SHOULD HAVE BEEN, YES.\" \"", "BUT HE HAS A FATHER, AND HE HAS HIS FATHER'S NAME.\" \"", "A NAME YOU SO THOROUGHLY DESTROYED.\" \"", "THAT WAS SIMPLE JUSTICE, MADAME.\" \"", "AND BELIEVE ME, IT BROUGHT ME NO JOY.\" \"", "AND NOW MY TASK'S ACCOMPLISHED.\" \"", "I'VE NO PARTICULAR PLACE IN THE WORLD,\" \"NO STRONG DESIRE IN LIFE, BUT TO MAKE AMENDS\" \"WHERE I'VE HURT THE INNOCENT.\" \"", "AVENGING ANGELS MAY NOT ASK FORGIVENESS\" \"OF THEIR VICTIMS.\" \"", "I AM NO LONGER THE INSTRUMENT OF GOD.\" \"", "I'VE BEEN PLUNGED BACK INTO NOTHINGNESS.\" \"", "I'M SEARCHING FOR...\" \"I'M LOST.\" \"", "MY SOUL, MY SELF.\" \"", "FOR EDMOND DANTES.\" \"", "YOU WILL NEVER FIND HIM.\" \"", "HE DIED A LONG TIME AGO IN THE CHATEAU D'IF.\" \"", "AND MUCH OF ME IS BURIED WITH HIM.\" \"", "BUT I CELEBRATE THE COUNT OF MONTE CRISCO'S\" \"RETURN TO THE WORLD OF MEN,\" \"AND I WISH FOR HIM, FROM THE DEPTHS OF MY HEART,\" \"THAT HE WILL FIND THE PEACE FOR WHICH HE EARNED.\" \"", "BUT, NO,\" \"NEVER WILL HE FIND THAT PERFECT LOVE,\" \"WHICH TWO YOUNG PEOPLE LOST,\" \"IRRETRIEVABLY LOST SO MANY, MANY YEARS AGO.\" \"", "BON VOYAGE.\" \"", "COUNTESS MONDEGO.\" \"", "GOODBYE, COUNT.\"" ]

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[ "Cellulases belonging to glycoside hydrolase families 6 and 7 contribute to the virulence of Magnaporthe oryzae.", "\nUpon infection, phytopathogenic fungi secrete an array of hydrolytic enzymes that can degrade components of the host epidermis, including waxes, the cuticle, and cell walls. ", "Cellulases, which can hydrolyze crystalline cellulose in the plant cell wall, are among these hydrolytic enzymes. ", "Here, we provide RNAi-based evidence to show that cellulases belonging to glycosyl hydrolase (GH) families 6 and 7 contribute to the penetration of the host epidermis and further invasion by the phytopathogenic fungus Magnaporthe oryzae. ", "The GH6 and GH7 cellulases likely include all members of the cellobiohydrolase family and some endoglucanases in M. oryzae. ", "Quantitative reverse-transcriptase polymerase chain reaction analysis indicated that more than half of the cellulases were highly induced during infection. ", "We constructed knock-down (KD) mutants of these cellulases using the building blocks method we reported previously. ", "The transcript levels of the target genes and cellulase activity were considerably reduced in the KD mutants. ", "The KD mutants resulted in fewer lesions, less penetration, and infection of fewer cells compared with the parent strain. ", "Cytological analyses showed that a high rate of papilla formation blocked invasion of the KD mutants into host cells. ", "These results suggest that the GH6 and GH7 cellulases play roles in the virulence of M. oryzae." ]

{ "pile_set_name": "PubMed Abstracts" }

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[ "Background\n==========\n\nCisplatin (CDDP) is a standard therapeutic agent for the treatment of various solid tumors. ", "Its efficacy however may be limited by patients' tolerance \\[[@B1]\\]. ", "The aim of our investigation was to identify ways to increase the efficacy of CDDP for cancer killing while enhancing the tolerance of normal cells.", "\n\nTumor cells are exposed to numerous cellular stresses, such as oncogene-induced genotoxic stress \\[[@B2]\\], oxidative stress \\[[@B3]\\], and metabolic stress \\[[@B4]\\], which are not affecting normal cells. ", "Thus, tumor cells are more dependent on stress support pathways for survival compared to normal cells. ", "Therapy targeting the stress response pathways, which can principally be reached through inhibiting the activity of these pathways or through overloading stress to overwhelm these pathways, may be specifically detrimental to cancer cells while sparing normal cells \\[[@B5]\\]. ", "For example it has been shown that interfering the cellular response to oxidative stress by a small molecule selectively kills cancer cells \\[[@B6]\\], and that targeting replicative stress response pathway resulted in specific killing of oncogene-driven tumors \\[[@B7]\\].", "\n\nSerum starvation in vitro and short-term food starvation (STS) in vivo have been demonstrated to reduce the levels of growth factors \\[[@B8]-[@B11]\\]. ", "In normal cells, depletion of paracrine growth factors reduces the activity of proliferation-stimulating signaling pathways and reduces basal cellular metabolism subsequently leading cells to enter a proliferation-quiescent status \\[[@B12]\\]. ", "In contrast, starvation may specifically induce stress in cancer cells because cancer cells struggle to adapt to the loss of external growth factors by adjusting autonomous growth stimulation and reprogramming their metabolism thereby maintaining continuous proliferation \\[[@B13]\\].", "\n\nWe investigated whether starvation affected the outcome of CDDP therapy in vitro and in animal models. ", "We show that serum starvation activates the cellular DNA damage response pathway specifically in cancer cells. ", "Our data suggest that starvation has a potential to increase CDDP-induced toxicity in cancer cells and simultaneously enhance the tolerance of normal cells to CDDP treatment.", "\n\nResults\n=======\n\nSerum starvation sensitizes ZL55cancer cells to CDDP\n----------------------------------------------------\n\nFACS analysis of BrdU pulse-labeled ZL55 cancer cells revealed that the fraction of cells in S-phase were decreased by 40% after 24 hours serum starvation compared to untreated control (Figure  [1](#F1){ref-type=\"fig\"}A-C). ", "BrdU incorporation in starved cancer cells was also reduced suggesting a reduction of DNA replication in the remaining S-phase cells (Figure  [1](#F1){ref-type=\"fig\"}B to 1A). ", "When cancer cells were exposed to CDDP in serum-starved conditions, an increased sensitivity was observed: the combined treatment of CDDP and serum starvation additively reduced the clonogenicity of human mesothelioma ZL55 cells in comparison to either treatment alone (Figure  [1](#F1){ref-type=\"fig\"}D).", "\n\n{#F1}\n\nTo explore the mechanism of the CDDP sensitization by serum starvation, the response of cancer cells to serum starvation was examined in more detail. ", "ATM is the key component in cellular stress responses to DNA damage and oxidative stress \\[[@B14],[@B15]\\]. ", "In ZL55 cells serum starvation induced a five-fold increase of nuclei positive for Serine1981-phosphorylated ATM (Ataxia Telangiectasia Mutated), compared to untreated control (Figure  [1](#F1){ref-type=\"fig\"}E, and Additional file [1](#S1){ref-type=\"supplementary-material\"}: Figure S1A and S1C). ", "The starvation-induced activation of ATM in ZL55 cells was confirmed by Western blot analysis (Figure  [1](#F1){ref-type=\"fig\"}F), which revealed a 40% increase in phosphorylated ATM. ", "Chk2 and p53 are downstream targets of ATM \\[[@B14],[@B15]\\]. ", "In addition to the activation of ATM, enhanced phosphorylation of Chk2 and 50% elevation of p53 protein levels were also observed in starved ZL55 cells. ", "We noticed that the serine15-phosphorylation status of p53 in cancer cells is not affected by serum starvation (Figure  [1](#F1){ref-type=\"fig\"}F).", "\n\nCDDP-triggered high levels of pATM-S1981 in ZL55 cells, which was further increased significantly (P\\<0.001)in the presence of serum starvation (Figure  [1](#F1){ref-type=\"fig\"}E and 1 F, and Additional file [1](#S1){ref-type=\"supplementary-material\"}: Figure S1B and S1D)resulting in more than 90% pATM-S1981 positive nuclei under immunofluorescent microscopy.", "\n\nIn summary, serum starvation and CDDP both activate ATM/Chk2/p53 signaling in ZL55 cancer cells and when combined result in an enhanced activation of the signaling and sensitization of cancer cells to CDDP.", "\n\nActivation of ATM/p53 is required for the sensitization of cancer cells to CDDP\n-------------------------------------------------------------------------------\n\nThe requirement for ATM/p53 activation in the serum starvation-mediated CDDP sensitization of cancer cells was examined. ", "We observed that the serum starvation-induced activation of p53 is ATM-dependent because it was inhibited by Ku-55933, a specific inhibitor of ATM \\[[@B16]\\] (Figure  [2](#F2){ref-type=\"fig\"}A). ", "Similar to the situation in ZL55 cells, serum starvation resulted in accumulation of p53 in an ATM-dependent manner in human colorectal cancer HCT116 cells (Figure  [2](#F2){ref-type=\"fig\"}B). ", "A functional role for p53 in the serum starvation-mediated CDDP sensitization was investigated by comparing p53 deficient (p53−/−) versus p53 proficient (p53+/+) HCT116 cells \\[[@B17]\\] (functionally characterized for response to CDDP in Additional file [1](#S1){ref-type=\"supplementary-material\"}: Figure S2). ", "Serum starvation-induced reduction of clonogenicity was significantly suppressed in p53-deficient HCT116 cells in comparison to p53-proficient HCT116 cells. ", "The combination of serum starvation and CDDP further decreased clonogenicity in the p53-proficient cells, but not in p53-deficient cells (Figure  [2](#F2){ref-type=\"fig\"}C). ", "These data obtained with the colorectal cancer cells suggest that the serum starvation-mediated sensitization of cancer cells to CDDP is dependent on ATM/p53 activation.", "\n\n{#F2}\n\nSerum starvation-triggered phosphorylation of AMPK is required for the stabilization of p53 in cancer cells\n-----------------------------------------------------------------------------------------------------------\n\nAMPK is an important regulator in cellular stress responses \\[[@B18]\\] and activates p53 in response to glucose starvation \\[[@B19]\\]. ", "The phosphorylation on the Thr-172 of AMPKα (pAMPK-Thr172) is the crucial step of AMPK activation \\[[@B18]\\]. ", "The involvement of AMPK in the cellular response to serum starvation was examined in cancer cells. ", "Increased levels of pAMPK-Thr172 were observed after serum starvation (Figure  [2](#F2){ref-type=\"fig\"}D). ", "In agreement with the activation of AMPK, elevated phosphorylation of acetyl-CoA carboxylase (ACC), one of the downstream targets of AMPK \\[[@B20]\\], was detected in starved ZL55 cells as well, which was suppressed in the presence of compound C, the specific inhibitor of AMPK \\[[@B21]\\] (Figure  [2](#F2){ref-type=\"fig\"}E). ", "Compound C inhibited the activation of p53 induced by both CDDP and serum starvation (Figure  [2](#F2){ref-type=\"fig\"}E), indicating a general role of AMPK in the activation of p53 in cancer cells. ", "Consistent with studies indicating that inhibition of IGF1 signaling is required for starvation-mediated sensitization of cancer cells to therapeutic drugs \\[[@B22],[@B23]\\], we observed a decrease of AKT phosphorylation upon serum starvation (Figure  [2](#F2){ref-type=\"fig\"}F). ", "The latter was not affected by ATM inhibitor Ku55933 or AMPK inhibitor Compound C, indicating that the inactivation of PI3K pathway and the activation of p53 by AMPK/ATM are likely independent mechanisms.", "\n\nIn addition, we verified the possible interference of ATM and AMPK inhibitors on mTOR signaling by testing their effects on the phosphorylation of S6, which is a target downstream of mTOR. ", "While serum starvation strongly inhibited the phosphorylating of S6, ATM inhibitor Ku55933 and AMPK inhibitor Compound C did not show any effect on the S6 phosphorylation (Figure  [2](#F2){ref-type=\"fig\"}G), suggesting that ATM inhibitor (Ku55933) and AMPK inhibitor (Compound C) were quite target-specific and do not interfere activity of mTOR signaling.", "\n\nShort-term food starvation sensitizes human mesothelioma xenografts to CDDP\n---------------------------------------------------------------------------\n\nTo investigate combined effect of starvation with CDDP in vivo*,* short-term food starvation (STS) was implemented \\[[@B22]-[@B24]\\]. ", "ZL55 cells were subcutaneously injected into nude mice. ", "Tumor-bearing animals were treated with the standard dose of CDDP (3 mg/kg) in the presence or absence of STS, or with STS alone once per week for three weeks. ", "No significant inhibition of tumor growth was observed when CDDP was administrated alone. ", "A mild (P\\<0.05) delay of tumor growth by STS alone was observed (Figure  [3](#F3){ref-type=\"fig\"}A). ", "However, a dramatic (P\\<0.01) inhibition of tumor growth was observed when mice were treated with the combination of CDDP and STS. ", "The average tumor volume was reduced by more than 60% three weeks after treatment, compared with untreated controls (Figure  [3](#F3){ref-type=\"fig\"}A). ", "Tumors continued growing for 4 weeks after ending of the combination treatment. ", "Then, tumors started to regress. ", "During the 8th to 10th week after the treatment, complete remission was observed in 60% combination-treated animals. ", "Animals with complete tumor remission were kept for additional at least 4 weeks, and no recurrence was observed. ", "No remission was observed in any other groups at the end of a 16 weeks follow-up period (Figure  [3](#F3){ref-type=\"fig\"}B).", "\n\n{#F3}\n\nAnimals lost 15% in average body weight during STS, but they regained most of the lost body weight during the next day after STS (Additional file [1](#S1){ref-type=\"supplementary-material\"}: Figure S3).No apparent effect on the evolution of body weight was observed overlong term duration (Figure  [3](#F3){ref-type=\"fig\"}C). ", "Thus, our data suggest that STS with water ad libitum is tolerable for animals and strongly sensitizes mesothelioma tumors to CDDP in vivo.", "\n\nSTS sensitizes human lung carcinoma A549 xenografts to CDDP\n-----------------------------------------------------------\n\nWe extended our in vitro and in vivo observations on human mesothelioma cells to human lung adenocarcinoma cells (A549). ", "As observed in ZL55 cells, serum starvation of A549 cells did trigger Chk2 activation, p53 accumulation and phosphorylation of histone H2AX (γ-H2AX), which is also an ATM target (Figure  [4](#F4){ref-type=\"fig\"}A). ", "However, activation of ATM and AMPK was not detectable (data not shown). ", "This might be due to different kinetics in ZL55 versus A549 cells. ", "Indeed, in serum-starved ZL55 cells at the same time point there was no difference in phospho-H2AX levels compared to untreated control. ", "We examined the sensitization of A549-derived xenografts to CDDP by STS in vivo as well. ", "No significant effect on tumor growth by STS or CDDP alone was observed (Figure  [4](#F4){ref-type=\"fig\"}B). ", "However, the combined treatment with CDDP and STS resulted in 65% reduction of tumor burden three weeks after treatment (Figure  [4](#F4){ref-type=\"fig\"}B) and complete remission of tumors without recurrence in 40% of animals treated with the combination. ", "No complete remission occurred in any other groups at the end of the 40 weeks follow-up period (Figure  [4](#F4){ref-type=\"fig\"}C). ", "Therefore, STS also sensitizes human lung adenocarcinoma xenografts to CDDP.", "\n\n{#F4}\n\nIn normal cells serum starvation results in proliferation arrest and protection against CDDP toxicity\n-----------------------------------------------------------------------------------------------------\n\nWe used cultured primary human mesothelial SDM104 cells to investigate the effects of serum starvation on the response of normal cells to CDDP. ", "In contrast to cancer cells where serum-starvation only partially reduced S-phase cells, FACS analysis of SDM104 cells showed that serum starvation alone (24 hours) resulted in complete abolishment of S-phase (BrdU-positive) cells and induction of a cell cycle arrest in G0/G1-phase, compared with untreated control (Figure  [5](#F5){ref-type=\"fig\"}A-C). ", "Survival of SDM104 cells growing in the continuous presence of serum was reduced by 74% by CDDP treatment compared to untreated control cells (Figure  [5](#F5){ref-type=\"fig\"}D). ", "In contrast, survival of serum starved SDM104 cells after exposure to CDDP was reduced only by 55% compared to untreated control cells, which was similar to reduction in survival observed after serum starvation alone, indicating a significant (P\\<0.002) increase of CDDP tolerance induced by serum starvation in normal SDM104 cells. ", "The serum starvation-mediated protective effects from CDDP toxicity were also observed in two additional normal primary human cell cultures (Additional file [1](#S1){ref-type=\"supplementary-material\"}: Figure S4).", "\n\n{#F5}\n\nIn agreement with the ATM activation status, CDDP exposure induced activation of p53 (phosphorylation and protein accumulation) and p21 accumulation (Figure  [5](#F5){ref-type=\"fig\"}E and 5F). ", "Consistent with the increased CPPD tolerance of serum-starved normal cells, CDDP-induced activation of ATM was suppressed by serum starvation (Figure  [5](#F5){ref-type=\"fig\"}E and 5F, and Additional file [1](#S1){ref-type=\"supplementary-material\"}: Figure S5B and S5D). ", "Although serum starvation alone did not induce activation of ATM, it triggered accumulation of p53 and the cell cycle inhibitor p21 (Figure  [5](#F5){ref-type=\"fig\"}F).", "\n\nIn order to investigate the mechanism responsible for p53 and p21 activation upon serum-starvation, we tested whether AMPK was activated by serum starvation in normal cells as well. ", "Serum starvation induced pAMPK-Thr172 in SDM104 cells, which was confirmed by the increased phosphorylation of ACC (Figure  [5](#F5){ref-type=\"fig\"}G). ", "The serum starvation-induced accumulation of p53 and the up-regulation of p21 in normal cells were inhibited by the AMPK inhibitor compound C (Figure  [5](#F5){ref-type=\"fig\"}G), suggesting that activation of AMPK is required for serum starvation-induced upregulation of p53 and p21. ", "Together, these results demonstrate that serum starvation induces in normal cells the activation of AMPK thereby initiating a p53/p21-mediated proliferation arrest, which confers resistance to CDDP-induced cytotoxicity.", "\n\nDiscussion\n==========\n\nOur study reveals that serum starvation sensitizes cancer but not normal cells to CDDP treatment. ", "Indeed, serum starvation activates in cancer but not normal cells ATM/Chk2/p53 signaling pathway. ", "The latter is also activated, as expected, after CDDP treatment. ", "Challenging serum starved cancer cells with CDDP triggers the hyper-activation of ATM/Chk2/p53 signaling resulting in sensitization of cancer cells to CDDP (Figure  [6](#F6){ref-type=\"fig\"}). ", "This observation is in line with the recently developed concept that overloading stress may exhaust the cellular stress response pathways thereby sensitizing cancer cells to chemotherapy \\[[@B5]\\].", "\n\n{#F6}\n\nOne of the potential reasons for ATM/Chk2/p53 activation by serum starvation may be due to a temporary loss of coordination between the cell proliferation driven by oncogenic mutations and the paracrine growth factors--stimulated cell growth, thus resulting in cellular stress. ", "For example, proliferation in the absence of serum is known to lead to depletion of the nucleotide pool \\[[@B25]\\], and the latter has been associated with altered DNA replication dynamics and genomic instability which trigger the activation of DNA damage response \\[[@B26]\\]. ", "In this context it is noteworthy that pemetrexed, an agent known to deplete nucleotide pools in cancer cells \\[[@B27]\\], improves the efficacy of CDDP therapy in the clinic \\[[@B28],[@B29]\\].", "\n\nAnother possibility for ATM/Chk2/p53 activation by serum starvation is the induction of oxidative stress, which directly oxidizes ATM thereby being independent of DNA damage induction \\[[@B15]\\]. ", "However, serum starvation did not induce the general oxidative stress marker heme oxygenase-1 \\[[@B30]\\] in both ZL55 and A549 cancer cell lines tested (Additional file [1](#S1){ref-type=\"supplementary-material\"}: Figure S6), ruling out oxidative stress being involved in starvation-induced CDDP sensitization. ", "Nevertheless, this mechanism could possibly be responsible for ATM activation in HCT116 cells where low expression levels of the ATM-activating MRN-complex protein MRE11 have been described \\[[@B31],[@B32]\\]. ", "Understanding the mechanism of serum starvation-induced ATM activation in cancer cells is beyond the scope of the present study and future work will address this issue.", "\n\nIt is noteworthy that serum starvation in cancer cells induced ATM and AMPK-mediated stabilization of p53 only, whereas CDDP treatment triggered both phosphorylation of p53 at Ser15 and stabilization of the protein. ", "Although Ser15 phosphorylation generally stabilizes the p53 protein, Ser15-phosphorylation-unrelated p53 stabilization has also been reported and potential mechanisms include acetylation and methylation. ", "However, an acetylation-dependent mechanism was excluded because of the absence of change of the Lys373 and Lys320 acetylation status of p53 under starvation condition (data not shown). ", "Methylation dependent mechanisms remain to be explored.", "\n\nIn contrast to cancer cells, serum starvation-activated AMPK triggers in normal cells the stabilization of p53 and elevation of p21 thus resulting in a cell cycle arrest. ", "It is known that DNA replication is blocked by CDDP-DNA-adducts, which can lead to DNA replication fork breakdown and subsequent DNA damage accumulation in replicating cells \\[[@B33],[@B34]\\]. ", "Therefore, the observed reduction in DNA replication upon serum starvation can explain the enhanced CDDP tolerance in normal cells (Figure  [6](#F6){ref-type=\"fig\"}). ", "Consistently, DNA damage response is not activated after CDDP treatment in serum-starved normal cells.", "\n\nThe outcome of combined STS/CDDP treatment, i.e. tumor growth delay and/or tumor eradication, is similar to a recent observation by Lee et al., ", "where sensitization of cancer cells to several chemotherapeutic drugs was induced by low glucose and low serum level in vitro and STS in vivo. ", "Inhibition of IGF1 signaling was required for starvation-mediated protection of normal cells and sensitization of cancer cells to therapeutic drugs \\[[@B22],[@B23]\\].", "\n\nWe show here an additional mechanism mediated by the negative regulatory signaling of AMPK, which is activated under stress conditions, e.g. nutrient starvation, to suppress proliferation \\[[@B35]\\]. ", "We observed that serum starvation activated AMPK in both cancer and normal cells. ", "Additionally, AMPK activity was necessary for the stabilization of p53 in response to serum starvation in both cancer and normal cells. ", "Thus, our study reveals that in addition to the inhibition of proliferation-enhancing IGF1 signaling pathway, the activation of the AMPK signaling cascade, which suppresses proliferation, is also involved in the starvation-induced protection of normal cells and sensitization of cancer cells to CDDP treatment.", "\n\nAlthough the design of our in vivo study does not allow extrapolating that the same mechanisms observed in vitro are operative in vivo, we nevertheless observed that STS sensitized xenografts of mesothelioma and lung cancer to CDDP treatment. ", "Prolonged fasting is now implemented in the treatment of several diseases including rheumatic diseases and chronic pain syndromes \\[[@B36]\\], indicating beneficial effects \\[[@B36]\\]. ", "In the context of cancer treatment, STS is well-tolerated in animal models and reduces the side effects of various chemotherapy regimens \\[[@B22],[@B24]\\]. ", "A case series report suggested that STS may also be applicable to cancer patients \\[[@B37]\\].", "\n\nConclusions\n===========\n\nIn normal cells, serum starvation-activated AMPK stabilizes p53 and p21 resulting in a proliferation arrest. ", "Serum starvation thereby protects normal cells from CDDP toxicity. ", "In cancer cells, serum starvation additionally activates the ATM/Chk2/p53 stress response signaling pathway, which is also induced by CDDP treatment. ", "The function of AMPK is required for maintaining this signaling. ", "Therefore, combining CDDP treatment with serum starvation results in the hyper-activation of ATM/Chk2/p53 signaling pathway, thus sensitizing cancer cells to CDDP. ", "In line with these in vitro observations, combining CDDP treatment with short-term food starvation in vivo delays tumor growth and induces tumor regression. ", "Thus, our study indicates that STS may enhance the efficacy of CDDP-based chemotherapy.", "\n\nMethods\n=======\n\nCell Cultures and Reagents\n--------------------------\n\nHuman mesothelioma ZL55 \\[[@B38]\\], lung carcinoma A549 \\[[@B39]\\] cells, the colorectal carcinoma cell lines HCT116 40.16 (p53+/+) and HCT116 379.2 (p53−/−) \\[[@B17]\\], and primary normal human mesothelial SDM104 \\[[@B40]\\] cells were cultured in M199 (Invitrogen)/MCDB106 (Sigma) (1:1) mixed medium supplemented with 15% FCS, 10 ng/ml EGF, and 0.4μg/ml hydrocortisone as described \\[[@B41]\\]. ", "The M199/MCDB106 medium without supplements was used for serum starvation assays. ", "All cell lines used in this study were authenticated by fingerprinting (Microsynth, Balgach, Switzerland). ", "CDDP (1667 μM saline solution, EbewePharma) was used for all in vitro and in vivo experiments. ", "The CDDP concentration was 8 μM for all in vitro experiments unless otherwise indicated. ", "For the in vitro treatments, cells were incubated with CDDP for 16 hours. ", "Ku55933 and Compound C (Merck) were used at concentrations of 5 μM and 20 μM, respectively. ", "To investigate the effects of serum starvation, CDDP treatment started 8 hours after the beginning of serum starvation and lasted 16 hours in starvation medium. ", "Colony formation assays and MTT cell proliferation assay were performed as described \\[[@B42],[@B43]\\]. ", "Due to their limited growth ability, proliferation of normal cells was examined with MTT assay.", "\n\nImmunostaining and Western blot\n-------------------------------\n\nFor immunostaining, cells were fixed with 4% formaldehyde in PBS for 20 minutes in room temperature. ", "Permeabilization was done with 100% methanol at 4°C for 4 minutes. ", "The incubations with the first and the secondary antibodies were done at room temperature for 2 and 1 hours, respectively. ", "Stained cells were mounted with Prolong Gold Anti-fade reagent with 4^′^,6 --diamidino-2-phenylindole (Invitrogen). ", "Images were taken with an inverse wide-field fluorescence microscope (Leica). ", "Anti-ATM-Ser1981 antibody (Cell Signaling) for immunostaining, anti-ATM-Ser1981 (Epitomics) for Western, anti-ATM (2C1) (GeneTex), anti-Akt, anti-phospho-Akt (Ser473), anti-phospho-AMPKα (Thr172) (40H9), anti-AMPKα, anti-Chk2, anti-phospho-p53-Ser15, anti-S6and anti-phospho-S6 (Cell Signaling), anti-phospho-Chk2-T68 (R&D System), anti-phospho-H2AX (γ-H2AX) (Millipore), anti-p53 and anti-p21 (Santa Cruz) were used according to the product instructions. ", "Western blot analysis was performed as described \\[[@B44]\\]. ", "For Western against ATM, protein extracts were run in 5% SDS-polyacrylamide gel while the rest were run in 13.5% SDS-polyacrylamide gel. ", "Western blots were quantified using ImageJ.\n\nFlow cytometry (FACS) analysis\n------------------------------\n\nBefore harvesting, cells were exposed to 10 μM BrdU for one hour. ", "FACS samples were prepared as described \\[[@B45]\\]. ", "After anti-BrdU antibody (BD Biosciences) and propidium iodide (PI) (Sigma) staining, FACS was performed with FACS Calibur (FACScan, BD Biosciences) and data was analysed with Summit v4.3software.", "\n\nIn vivo experiments\n-------------------\n\nAll animal experiments were approved by Kantonales Veterinätamt Zürich and performed in accordance with the ethical principles and guidelines for experiments on animals of Swiss Academy of Medical Sciences. ", "8 week-old CD1 female nude mice (Charles River and Harlan) were randomly divided into groups. ", "ZL55 cancer cells or A549 cancer cells in 100 μl PBS (0.5x10^6^ cells per animal) were subcutaneously injected into the left flank side of the mice. ", "Tumor volume was measured by calliper and calculated with the formula: Width^2^×Length/2 \\[[@B46]\\]. ", "Tumor growth in untreated animals was used as control. ", "Treatments started when the tumor volumes reached 30±17 mm^3^. CDDP (3 mg/kg) was injected i.p. ", "once per week for three weeks. ", "Short-term fasting was implemented 32 hours prior and 16 hours post-injection with water ad libitum. ", "During the treatment, animals were monitored routinely for body weight loss and general behaviour. ", "Tumor growth and animal weight were recorded once per week for at least 16 weeks. ", "Animals were sacrificed when any of the following signs for severe suffering was observed: the tumor volume reached 500 mm^3^; body weight loss was observed for 4 consecutive days; loss of more than 15% body weight; sign of severe sickness, for example, reduced mobility and eating, ruffled hair, and hunched back posture.", "\n\nStatistical analysis\n--------------------\n\nMann--Whitney or two-tailed *t*-Test was performed.", "\n\nCompeting interests\n===================\n\nThere is no competing interest to disclose.", "\n\nAuthors' contributions\n======================\n\nYS, EF, and TM conceived and designed the experiments. ", "YS performed the experiments. ", "TM assisted the flow cytometry assays and KO was involved in the initiation of the animal assay. ", "YS, EF, TM, KO, and MP analysed the data. ", "YS and EF provided and prepared the reagents/materials/analysis tools for the experiments. ", "YS, EF and RS wrote the manuscript. ", "TM and MP corrected the manuscript. ", "All authors read and approved the final manuscript.", "\n\nPre-publication history\n=======================\n\nThe pre-publication history for this paper can be accessed here:\n\n<http://www.biomedcentral.com/1471-2407/12/571/prepub>\n\nSupplementary Material\n======================\n\n###### Additional file 1\n\n**Figure S1. ", "Serum starvation and CDDP both activate ATM in ZL55 cancer cells and when combined result in an enhanced activation of the ATM.** ", "Anti-phosphoATM-Ser1981 (pATM) immuno-staining of untreated ZL55 cells (A) and those treated with 8 μM CDDP alone (B), serum starvation alone (C), or both together (D) are shown. ", "In (A-D), images of anti-pATM staining (in red) are in left, and images of DAPI staining in middle while on the right are the overlap. \"", "S\" in (C) and (D) stands for serum starvation. **", "Figure S2.** ", "p53 is knockout in HCT116^p53−/−^cells. ", "No p53 was detected in the protein extract from CDDP-treated HCT116^p53−/−^ cells while it was induced in p53-proficient HCT116 cells. ", "β-Actin was used as loading control. **", "Figure S3.** ", "STS with water ad libitum is tolerable for animals. ", "Animals regained most of the lost body weight during the next day after starvation. **", "Figure S4.** ", "Serum starvation protects normal cells from CDDP cytotoxity. ", "MTT assays were performed after primary normal cell cultures LP9, SDM104 and SDM85, which was established from a normal pleural tissue received from a patient undergoing cancer unrelated thoracic surgery (this study was approved by the Zurich University Hospital ethic committee and a written informed consent was obtained from the patient), were treated with CDDP alone, serum starvation alone or both together (\\* for P\\<0.002; \\*\\* for P\\<3.0x10^-5^). ", "CDDP8 and CDDP20 stands for 8 μM and 20 μM CDDP, respectively. **", "Figure S5.** ", "Serum starvation suppressed the CDDP-induced activation of ATM in normal cells. ", "Anti-phosphoATM-Ser1981 (pATM) immuno-staining of untreated SDM104 cells (A) and those treated with 8 μM CDDP alone (B), serum starvation alone (C), or both together (D) are shown. ", "In (A-D), images of anti-pATM staining (in red) are in left, and images of DAPI staining in middle while on the right are the overlap. \"", "S\" in (C) and (D) stands for serum starvation. **", "Figure S6.** ", "Serum starvation does not induce the expression of oxidative stress marker, HO-1 in ZL55 and A549 cancer cells. ", "Western blot results with antibodies against HO-1 for protein extracts from untreated control and those treated with CDDP alone, serum starvation alone, or both together are shown for ZL55 (A) and A549 (B) cells. ", "β-Actin was used as loading control.", "\n\n###### \n\nClick here for file\n\nAcknowledgements\n================\n\nThis work was supported by the Stiftung für Angewande Krebsforschung and Huggenberger-Bischoff Stiftung. ", "We are grateful to Dr. Bert Vogelstein (Johns Hopkins University, Baltimore, MD) and Dr. James Rheinwald (Harvard Medical School) for kindly providing HCT116 and LP9 cell lines, respectively. ", "We also would like to thank Dr. Ian Frew (Institute of Physiology, University of Zurich) and Dr. Massimo Lopes (Institute of Molecular Cancer Research, University of Zurich) for suggestions.", "\n" ]

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[ "Posts Tagged ‘Sweet Seymour Skinner’s Baadasssss Song\n\nBart inadvertently has Principal Seymour Skinner fired, him being replaced by Ned Flanders\n\n100th episode! ", "We’ve made the first meaningless (maybe slightly above complete meaninglessness) milestone! ", "Today is the airing of the 500th episode, so, to celebrate, we (I) will be reviewing all of the -00th episodes, in order, leading up to “At Long Last Leave” tonight. ", "Let’s roll the tape!", "\n\nThe line of Bart replying “not likely” to Marge’s comment on people laughing at him in 20 years from now (then) was slightly predicting the future. ", "Marge’s line, “I just think they’re neat,” in reference to potatoes is one of my favorite moments; Superintendent Chalmers’s line about the “low test scores, class after class of ugly, ugly children” is another line I love. ", "Some other notable quotables/moments: “They don’t have them group turlets here no more, do they?,” ", "Homer’s binge on peanut butter cups in Flanders’ office, the smoking “K” from the Kwik-E-Mart moments after three bombs (were they bombs?) ", "headed their way from Principal Skinner’s army range.", "\n\nThe friendship between Principal Skinner and Bart is one seen time and time again – two enemies come together after an incident and become good friends, and then an idea/something of that nature happens to bring everything back to the way it was again before the plot ends, with an emotional (usually emotional?) ", "goodbye scene before things go back to normal and they are enemies once more. ", "The scenes of them together were nice; I particularly liked the animation during the beach scene (where Bart does a surprisingly right-on-the-first-try hit with a log for a crab on Skinner’s ear) with the sun setting in the background. ", "The spider biting the back of Bart’s head (which Lisa had thought was guilt for getting Skinner inadvertently fired) was slightly disturbing, if I recall correctly, I remember hearing someone (any help specifying who that person was would be appreciated, but is not required, I’m too lazy at this moment to search for it myself) on the commentary for this episode say that it happened to his daughter, and the joke became unfunny to him from then on (albeit laughing about it).", "\n\nOverall, this seems, to be at least, to be a tad anti-climactic episode for being the show’s 100th, but it is funny, entertaining, slightly emotional, solid, generally good episode nonetheless. ", "I give it a 5/5, A+." ]

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[ "On the Fox News host Laura Ingraham’s show Monday night, the conservative pundit made a bizarre defense of Trump administration policy that separates families at the border by arguing that children were being held in what amounted to “boarding schools.”", "\n\nIngraham was pulling that description from an article in the San Diego Union-Tribune, which led with a list of classrooms, soccer goals, and a “medical clinic with superheroes like Wonder Woman, Superman, and the Hulk on the walls” in a facility for migrant children in California, at which about 10 percent of the children were separated from their parents. ", "But the Union-Tribune article immediately went on to describe, “on closer inspection,” fencing, 24-hour video surveillance, and alarms that blast at the possibility of “a potential escape.”", "\n\n“More kids are being separated from their parents and temporarily housed in what are essentially summer camps, or as The San Diego Union Tribune described them today, as basically looking like boarding schools,” Ingraham said on her show. “", "The American people are footing a really big bill for what is tantamount to a slow-rolling invasion of the United States.”", "\n\n.@IngrahamAngle: \"The American people are footing a really big bill for what is tantamount to a slow rolling invasion of the United States.\" ", "pic.twitter.com/HJd6TsTEca — Fox News (@FoxNews) June 19, 2018\n\nIngraham’s choice to downplay the distress of the children held at these migrant facilities angered some who had read reports of children, separated from their parents, who were detained in “cages” and who in videos “sound like they’re crying so hard, they can barely breathe.”", "\n\nIngraham was not the only one to come under criticism Monday for statements on the show. ", "Jeff Sessions, who appeared on the show to defend the zero-tolerance policy, like Ingraham said that “we’re doing the right thing, we’re taking care of these children.” ", "But he also was criticized for the tone-deaf way in which he defended the administration against accusations of similarities to Nazi Germany.", "\n\n“Well, it’s a real exaggeration,” Sessions said. “", "Of course, in Nazi Germany, they were keeping the Jews from leaving the country.”", "\n\nMany conservatives, including Laura Bush, Lindsey Graham, and Anthony Scaramucci, have condemned the zero-tolerance policy as cruel and called on the administration to overturn it.", "\n\nUpdate, June 19, at 10:30 a.m.: Ingraham responded to the criticism on her show, The Ingraham Angle:" ]

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