Question: how long do the effects of medrol last?
Answer: After taking a dose of Methylprednisolone tablet from a Medrol Dosepak it should be out of your system after approximately 13 to 20 hours. Methylprednisolone tablets have an elimination half-life of approximately 2.5 hours to 3.5 hours. This is the time it takes for the drug levels in your plasma to reduce by half.