Question: does a picc line have to be flushed with heparin?
Answer: For example, if your child needs medicine once every 24 hours, the line should be flushed before and after the medicine is given, and 12 hours later. Heparin is a medicine that prevents clotting and helps keep the PICC line open. ... After the dose, flush it twice: once with normal saline and once with heparin.