Question: is prednisone and methylprednisolone the same thing?
Answer: Although they are both glucocorticoids, methylprednisolone and prednisone are not exactly the same. Prednisone must be metabolized to its active form, prednisolone, in order to have an effect on the body. A dose of 4 mg of methylprednisolone is equivalent to a 5 mg prednisone.