Question: kidney disease affects what body systems?
Answer: The Blood System. Damaged kidneys slow the production of the hormone erythropoietin, resulting in anemia and iron deficiency. ... 
The Cardio-Vascular System. ... 
The Integumentary System (Skin) ... 
The Skeletal System. ... 
Joints. ... 
The Circadian System. ... 
The Nervous System. ... 
The Digestive System.