Question: is glyburide and glipizide the same thing?
Answer: Both glyburide and glipizide are second generation sulfonylureas. The drugs have slightly different pharmacokinetic characteristics. 1,2 Although both are dosed once or twice daily, time to onset of the drug and duration of effect are slightly longer for glyburide (nonmicronized formulation), as is the serum half-life.