Question: what does it mean when a guy says no mames?
Answer: No mames is sometimes extended to no mames güey (no-mah-mess-goo-ee) and no mames wey (no-mah-mess-way), which both roughly mean “No way, dude!” Wey and güey are both Spanish slang words meaning “dude” or “guy,” though wey can also connote “idiot.”