Question: why are gram positive bacteria more resistant to antibiotics that disrupt plasma membranes?
Answer: Why are gram-positive bacteria typically more resistant than gram-negative bacteria to antibiotics that disrupt plasma membranes, such as polymyxin B? Gram-Positive Bacteria has a cell wall composed of a thick layer of peptidologlycan containing teichoic and lipoteichoic acid complexed to the peptidoglycan.