Question: what is the best medication for severe heartburn?
Answer: The proton-pump inhibitors esomeprazole (Nexium 24HR), lansoprazole (Prevacid 24HR), and omeprazole (Prilosec OTC) are sold over-the-counter to treat frequent heartburn (two or more times per week) for 14 days. These types of medicines are also available as higher-strength prescriptions.