Question: what is the best over-the-counter medication for poison ivy?
Answer: Apply an over-the-counter corticosteroid cream for the first few days. Apply calamine lotion. Take oral antihistamines, such as diphenhydramine (Benadryl, others), which may also help you sleep better. Soak in a cool-water bath containing an oatmeal-based bath product (Aveeno).