Question: are buspar and zoloft the same?
Answer: Buspar vs. Zoloft differences. Buspar (buspirone) and Zoloft (sertraline) are both drugs used to treat anxiety. The main difference is that Zoloft belongs to a drug class of antidepressants called SSRIs (selective serotonin reuptake inhibitors), so researchers know how Zoloft works in treating anxiety.