Question: how does flp frt work?
Answer: FLP recombinase, which is named after its ability to invert or 'flip DNA', is derived from the yeast S. cerevisiae (Gronostajski and Sadowski 1985). The FLP system works in a similar fashion to the Cre system. The FLP recombinase recognizes FRT sites and initiates site directed gene recombination between those sites.