Question: is zegerid the same as prilosec?
Answer: Are Zegerid and Prilosec the Same Thing? Zegerid (omeprazole/sodium bicarbonate) and Prilosec (omeprazole) are used to treat ulcers, gastroesophageal reflux disease (GERD), and other conditions involving excessive stomach acid production. Both Zegerid and Prilosec contain a proton-pump inhibitor (PPI).