Question: do all nsaids cause fluid retention?
Answer: Because NSAIDs block the production of the COX-1 and COX-2 prostaglandins, renal side effects are not uncommon, occurring in approximately 1% to 5% of NSAID users. By inhibiting COX-2's natriuretic effect, thereby increasing sodium retention, all NSAIDs carry with them the consequent risk of increased fluid retention.