Question: how often can you take 500mg tylenol?
Answer: For the 500 mg pills (extra-strength tablets), you can take up to 2 pills every 8 hours (or twice a day). The highest dose of acetaminophen you should ever take (not that you should try), is 4 grams per day. That would be 8 extra-strength Tylenol tablets (500 mg each) or 12 regular-strength tablets (325 mg each).