Question: which antidepressant works best for premature ejaculation?
Answer: For this reason, selective serotonin reuptake inhibitors (SSRIs), such as escitalopram (Lexapro), sertraline (Zoloft), paroxetine (Paxil) or fluoxetine (Prozac, Sarafem), are used to help delay ejaculation. Of those approved for use in the United States, paroxetine seems to be the most effective.