Question: can i take aleve cold and sinus with nyquil?
Answer: The overall point here is that it is fine to take Aleve with NyQuil. They don't affect each other. If you have been taking Aleve to help with pain symptoms (e.g. muscle pain, headaches, etc...) throughout the day and want to add on NyQuil at night to help with cold/flu symptoms, there is no problem with that.