Question: are gabapentin and amitriptyline the same?
Answer: Gabapentin has virtually no dangerous drug interactions compared with amitriptyline, since gabapentin is not a substrate to or inhibitor of any hepatic P450 isoenzymes, as is amitriptyline. Gabapentin is less than 3% bound to any plasma proteins. Amitriptyline is greater than 90% bound to α-glycoprotein.