Question: is aciphex the same as zantac?
Answer: Aciphex is a proton pump inhibitor (PPI) and Zantac is a H2 (histamine-2) receptor blocker. Zantac is available over-the-counter (OTC) and as a generic. Side effects of Aciphex and Zantac that are similar include diarrhea, headache, and sleep problems (insomnia).