Question: what is the difference between losartan and irbesartan?
Answer: Losartan is different from other ARBs including valsartan and irbesartan because it has a shorter duration of action. This is important. Losartan, taken once daily, does not last the full 24 hours at lower doses like 25 or 50 mg. At 100 mg daily losartan does last the full 24 hours.