Question: does grapefruit juice interfere with methotrexate?
Answer: Grapefruit Juice “In a sense, you are overmedicating,” says Jalloh. If you take cyclosporine or methotrexate (Rheumatrex, Trexall), which may also be affected by the juice, talk to your doctor if you want to drink grapefruit juice on a regular basis.