Question: how is cml differentiated from a leukemoid reaction?
Answer: CML must be differentiated from leukemoid reactions (Chapter 170), which usually produce WBC counts lower than 50,000/µL, toxic granulocytic vacuolation, Döhle's bodies in the granulocytes, absence of basophilia, and normal or increased LAP levels; the clinical history and physical examination generally suggest the ...