Question: how long does it take for hydrochlorothiazide to lower blood pressure?
Answer: More sodium is then excreted in the kidney with accompanying fluid. Pharmacological effects begin in about 2 hours after an oral dose, peaks in 4 hours, and lasts for about 6 to 12 hours. Hydrochlorothiazide is not metabolized, and a majority is excreted in the urine unchanged.