Question: how many combinations of 5 numbers in 45?
Answer: Powerball players must select five different numbers, from 1 to 45, and one powerball number, from 1 to 45. That means there are 45 x 44 x 43 x 42 x 41 possible combinations of the five numbers and 45 possible powerballs. Do the multiplication and you get 6.6 billion possible combinations.