Question: which antidepressant has the least effect on libido?
Answer: Fortunately, one antidepressant rarely causes sexual side effects, Wellbutrin (bupropion). Wellbutrin is just as effective as the most popular class of antidepressants, the SSRIs (Prozac, Paxil, Zoloft, Celexa, Lexapro, Luvox). Its nonsexual side effects are no worse, and it's unlikely to cause sexual side effects.