Question: what is the difference between embryonic and induced pluripotent stem cells?
Answer: hESCs are derived from the inner cell mass of fresh or frozen embryos at the blastocyst stage of development5 (Figure 1a). ... In contrast to hESCs, hiPSCs are derived by “reprogramming” of somatic cells to a pluripotent state through the overexpression of a key set of transcription factors (Figure 1b).