Question: what is the best treatment for severe rheumatoid arthritis?
Answer: NSAIDs. Nonsteroidal anti-inflammatory drugs (NSAIDs) can relieve pain and reduce inflammation. ... 
Steroids. Corticosteroid medications, such as prednisone, reduce inflammation and pain and slow joint damage. ... 
Disease-modifying antirheumatic drugs (DMARDs). ... 
Biologic agents.