Question: how long to hold xarelto before spinal anesthesia?
Answer: Stop rivaroxaban 1 day before surgery/procedure (skip 1 dose), which corresponds to 2 half-lives elapsed between stopping rivaroxaban and surgery. Major surgery/spinal anesthesia. Stop rivaroxaban 2 days before surgery (skip 2 doses), which corresponds to 4-5 half-lives elapsed between stopping rivaroxaban and surgery.