Question: is it possible to get pregnant while on depo?
Answer: Hormone implants cause pregnancy in less than 1 in 100 women. Due to its simplicity, she chose the hormone shot Depo-Provera, which requires injections every 12 weeks for optimal protection. Depo-Provera is 99% effective in preventing pregnancy, which means that 1 in 99 women will conceive while taking it.