Question: can xifaxan be used long term?
Answer: Lactulose therapy can prevent recurrent HE9; however, long-term use is limited by numerous adverse effects, often resulting in nonadherence to therapy. Rifaximin (Xifaxan; Salix Pharmaceuticals, Inc, Raleigh, NC) is an oral antimicrobial agent with broad-spectrum activity that is gut-selective and nonsystemic.