Question: what is the best medication for severe allergies?
Answer: Over-the-counter:Cetirizine (Zyrtec), fexofenadine (Allegra), levocetirizine (Xyzal), and loratadine (Claritin, Alavert) are taken by mouth. ... 
Prescription: Desloratadine (Clarinex) is a medication taken by mouth.