Question: how long does it take doxycycline hyclate to work for lyme disease?
Answer: Treatment for 10 to 14 days is recommended (10 d for doxycycline and 14 d for amoxicillin, cefuroxime axetil, or phenoxymethylpenicillin). Longer treatment was previously recommended. Erythema migrans typically shows improvement within a few days after the institution of appropriate antibiotic therapy.