Question: how often can you take ibuprofen with tylenol?
Answer: by Drugs.com It is safe to take Tylenol and Ibuprofen together at the same time for pain. They both work in slightly different ways to relieve the pain. Assuming you are a healthy, average weight adult for tooth ache you could take two Tylenol 500mg every 6 hours with a maximum daily dose of 8 tablets a day.