Question: can you take ibuprofen while running a marathon?
Answer: Ibuprofen (Advil, Motrin) The Bad: Can impair kidney function, more so if taken before or during a run. (NSAIDs inhibit blood-flow to the kidneys. Kidney circulation can also be suppressed by dehydration. So a dehydrated, NSAID- using athlete's kidneys could struggle to maintain a proper fluid and electrolyte balance.)