Question: how long after methylprednisolone can i take ibuprofen?
Answer: In general, you should wait between 6 to 8 hours before taking Advil or Aleve after finishing methylprednisolone to avoid additive GI side effects. It should be noted that methylprednisolone does have a long half-life (around 18-36) hours and will last in the body for 4 to 7 days after finishing your course of therapy.