Question: how long do you cook frozen chicken breast in oven at 375?
Answer: Preheat oven to 375.
Spray baking dish with non-stick spray.
Place frozen chicken breast in dish.
Top with sauce.
Bake for 45 minutes.
Options: Add veggies for a one dish meal.
If using cheese, put it on the last 2 minutes of cook time. This gives it time to melt and brown if you like it that way.