Question: how long does it take to get used to zonisamide?
Answer: The recommended initial daily dose of zonisamide is 100 to 200 mg for adults and 2 to 4 mg/kg per day for children. Because steady state is reached within 14 days, dosages should be increased at 2-week intervals to a target maintenance dose of 400 to 600 mg/day in adults and 4 to 8 mg/kg per day in children.