Question: what is the main difference between rough endoplasmic reticulum and smooth endoplasmic reticulum?
Answer: There are two basic types of ER. Both rough ER and smooth ER have the same types of membranes but they have different shapes. Rough ER looks like sheets or disks of bumpy membranes while smooth ER looks more like tubes. Rough ER is called rough because it has ribosomes attached to its surface.