Question: what is the difference between doxycycline hyclate and doxycycline monohydrate?
Answer: Doxycycline monohydrate and doxycycline hyclate differ only in their salt form- monohydrate and hyclate. Hyclate has greater solubility than monohydrate. However, the monohydrate form may be more tolerable. Regardless of their solubility differences, both forms are effective at treating infections.