Question: what is the best over the counter medicine to take for a sinus headache?
Answer: Such OTC medications (Sudafed, others) are available in liquids, tablets and nasal sprays. Pain relievers. Pain caused by pressure buildup in the sinus cavities may be relieved by pain relievers such as acetaminophen (Tylenol, others) or ibuprofen (Advil, Motrin IB, others).