Question: why does adp inhibit gluconeogenesis?
Answer: During starvation, gluconeogenesis predominates because the level of F-2,6-BP is very low. ... Conversely, pyruvate carboxylase, which catalyzes the first step in gluconeogenesis from pyruvate, is activated by acetyl CoA and inhibited by ADP. Likewise, ADP inhibits phosphoenolpyruvate carboxykinase.