Question: how long does it take for your body to get used to blood pressure medicine?
Answer: So when we start medicines and move someone from, let's say, a blood pressure of 160 or 170 systolic, down to 140 or 130, yes, you may feel tired when you start taking the medicine. That's natural. That's just the body adjusting to living at a lower blood pressure. But that effect goes away after 10 days to two weeks.