Question: do thiazide diuretics cause hyponatremia?
Answer: Thiazides are a common cause of severe hyponatremia in hospitalized patients5) and are associated with high morbidity and mortality6, 7). Virtually all cases of severe diuretic-induced hyponatremia have been due to a thiazide-type diuretic6-12). In contrast, loop diuretics are implicated much less commonly7).