Question: does omeprazole cause kidney issues?
Answer: Acid Reflux Drugs Linked to Kidney Disease Risk. Patients taking PPIs 28.4 times more likely to develop chronic kidney disease. People taking protein pump inhibitors (PPIs) such as omeprazole (Prilosec), esomeprazole (Nexium) and lansoprazole (Prevacid) have a higher risk of developing kidney disease, a new study says.