Question: is cetirizine the same as diphenhydramine?
Answer: Zyrtec (cetirizine) and Benadryl (diphenhydramine) are two antihistamines that can treat allergies. Zyrtec is a second-generation antihistamine and Benadryl is a first-generation antihistamine. While they may treat similar symptoms such as runny nose and sneezing, they have some differences.