Question: what is the most powerful weapon in fallout 4?
Answer: Arguably the most powerful weapon in the game is the Nuka-Nuke Launcher found in Nuka-World. It's essentially a Fat Man that has been modified to hurl modified mini-nukes known as Nuka-Nukes at foes. These Nuka-Nukes deal a whopping 833 damage at a decent range from the enemy.