Question: are muscarinic receptors ionotropic or metabotropic?
Answer: Muscarinic ACh receptors (mAChRs) are metabotropic receptors that, depending on their coupling to G-protein α-subunits, can inhibit or excite postsynaptic neurons, while nicotinic ACh receptors (nAChRs) are ligand-gated cation channels that directly excite postsynaptic neurons.