Question: what is the difference between che ora e and che ore sono?
Answer: There's no difference in meaning,both mean 'what time is it?” It just changes that if you say “Che ora è? ' it's like literally saying “what hour is it?” While if you ask “Che ore sono?” It's like literally saying “what hours are they?” It just changes the word 'ora' and the verb to be (essere) from singular to plural.