Question: is 300mg of effexor a lot?
Answer: The usual starting dosage of Effexor XR for major depressive disorder (MDD) is 75 mg once daily. The maximum dosage for MDD is 225 mg once daily. However, daily dosages of 300 mg or higher may be needed to treat MDD in some people. This would be considered an off-label (nonapproved) use.