Question: what is a major difference between dna and rna?
Answer: DNA contains the sugar deoxyribose, while RNA contains the sugar ribose. The only difference between ribose and deoxyribose is that ribose has one more -OH group than deoxyribose, which has -H attached to the second (2') carbon in the ring. DNA is a double-stranded molecule, while RNA is a single-stranded molecule.