Queridos, voltei a postar no zaluzejos (tumblr). O blog, talvez, tenha saturado de mim. Por isso, quem quiser continuar me acompanhando, e so clicar no link abaixo.ZALUZEJOS sabendoque assim dizendo poema estava te matandomesmo assimte dissesabendoque assim fazendovoce estava durandofoi duromesmo assimte trouxemesmo assimte fizmesmo sabendo que iasfugazser infelizsempre infelizmesmo assimte quismesmo sabendoque ia te quererficar querendoe pedir bisPaulo Leminski, em "Caprichos & Relaxos" SENS4, Session 5: Eliminating recalcitrant intracellular molecules: the lysosome Jeffrey Grubb spoke about new methods for delivering missing enzymes to the lysozomes of patients suffering from lysosomal storage diseases. Several of these should be able to deliver any protein to the lysozome, including novel ones capable of degrading undesirable intracellular molecules that accumulate with age and that normal lysosomes cant handle a central goal of the LysoSENS project.Ana Maria Cuervo spoke about the relationship between autophagy and aging. Rates of autophagy decline with age, and they recently showed that artificially maintaining autophagy at youthful levels in old mouse livers improves their function (which we previously discussed here).John Schloendorn discussed ongoing work at the SENS Foundation Research Center to develop new enzymes that can degrade harmful intracellular junk that accumulates with age. So far, they have discovered enzymes that can degrade A2E and 7-ketocholesterol, which are implicated in macular degeneration and atherosclerosis, respectively. Their next step will be to construct a drug delivery system to get these enzymes to lysozomes, possibly using methods similar to those of Jeffrey Grub. On the lighter side, Schloendorn also described some of the Centers methods for building functional lab equipment on the cheap, all good examples for aspiring DIY biologists.(For an index of coverage of all sessions, see here.) Intermittent fasting for health and longevityBy vishy on October 21, 2013 in Food, Running Pic courtesy richeats.tvOn the eve of Karwa Chauth, I thought this would be a topical post. Todd Becker (author of the Getting Stronger blog) has written on this topic at length. My contribution in this post is to summarize the salient points for the ADD generation. The only reason I filed this post under Running is because of the earlier hormetism post linking cold showers and barefoot running.1934 calorie restriction study on lab ratsOne of the first scientifically rigorous demonstrations of the benefits of hormesis was a 1934 study of calorie restriction (often abbreviated CR) in laboratory rats, conducted by Mary Crowell and Clive McCay at Cornell. They found that reducing the calories of rats by 30-50%, supplemented with adequate micro-nutrients, could almost double their lifespans. Later studies found continued lifetime extension with calorie restriction up to 65%. In addition, the rats remained energetic and youthful in appearance, with greatly reduced incidence, and delayed onset, of age-related diseases. This same phenomenon has been observed in a variety of other animals.From monkeys and macaques to humans?Studies on rhesus monkeys and macaques at the University of Wisconsin have found that the calorie-restricted monkeys have significantly less diabetes, cancer, cardiovascular disease, and neurodegenerative diseases. Their fasting insulin and glucose levels are greatly reduced, and they have higher insulin sensitivity and excellent lipid profiles.