Novo Blog http://luciseara.blogspot.com.br COACHING - SOLUCOES ESPERANDO POR VOCE Advanced Glycation Endproducts for 4 weeks Improves Insulin Sensitivity in Overweight WomenAlicja B. Mark, PhD*,1, Malene W. Poulsen, MSc*,1,Stine Andersen, MSc1, Jeanette M. Andersen, MSc1,2,Monika J. Bak, MSc1,3, Christian Ritz, PhD1, Jens J. Holst, MD, PhD4, John Nielsen, PhD2, Barbora de Courten, MD, PhD3,5,6, Lars O. Dragsted, PhD1 and Susanne Bugel, PhD.1+Author Affiliations1Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Denmark.2Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.4NNF Center for Basic Metabolic Research, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.5Baker IDI Heart and Diabetes Institute, Melbourne, Australia.6Steno Diabetes Center, Copenhagen, Denmark.Corresponding author: Susanne Bugel, E-mail: shb@life.ku.dk.* Authorship equally shared.AbstractObjective High heat cooking of food induces formation of advanced glycation endproducts (AGEs), which are thought to impair glucose metabolism in type 2 diabetic patients. High intake of fructose might additionally affect endogenous formation of AGEs. This parallel intervention study investigated whether addition of fructose or cooking methods influencing the AGE content of food affect insulin sensitivity in overweight individuals.Research design and methods Seventy-four overweight women were randomized to follow either a high- or low-AGE diet for 4 weeks, together with either fructose or glucose drinks. Glucose and insulin concentrations fasting and 2-h after an oral glucose tolerance test were measured before and after the intervention. Homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity index (ISI0,120) were calculated. Dietary and urinary AGE concentrations were measured (LC-MS/MS) to estimate AGE intake and excretion.Results When adjusted for changes in anthropometric measures during the intervention the low-AGE diet decreased urinary AGEs, fasting insulin, and HOMA-IR, compared with the high-AGE diet. Addition of fructose did not affect any outcomes.Conclusions Diets with high AGE content may increase development of insulin resistance. AGEs can be reduced by modulation of cooking methods but is unaffected by moderate fructose intake.http://care.diabetesjournals.org/content/early/2013/08/16/dc13-0842.abstract Apesar de terapias novas e eficazes drogas, a resistencia a insulina (RI), diabetes mellitus tipo 2 ( DM2 ) e suas complicacoes permanecem como grandes desafios medicos. Aceita-se que a RI, muitas vezes associada com o excesso de nutricao e obesidade, os resultados de estresse oxidante cronicamente elevada ( OS) e inflamacao cronica. Menos reconhecido e que uma das principais causas para essa inflamacao e o consumo excessivo de produtos de glicacao avancada (AGEs) com a dieta ocidental padrao. AGEs , que foram em grande parte pensado como derivados oxidativos decorrentes da hiperglicemia diabetica, sao cada vez mais vistos como um risco potencial para a lesao das celulas- das ilhotas, IR periferica e diabetes. Aqui nos discutimos as relacoes entre AGEs exogenos, inflamacao cronica, IR, e diabetes tipo 2 . Propomos que a pressao AGE oxidante exogeno a deplecao cronica de mecanismos de defesa inatos e um factor importante, o que aumenta a susceptibilidade a inflamacao, IR, DM2 e suas complicacoes. Finalmente, uma revisao de evidencias sobre restricao dietetica AGE como uma intervencao nao farmacologica, o que reduz de