estudo e o primeiro relato que mostrou aumento de ICAM-1 na derme apos 6 meses do inicio do tratamento. Esse aumento foi estatisticamente significativo, demonstrando aumento dos capilares sanguineos na derme. Sabe-se que o ICAM e uma glicoproteina de membrana de adesao intercelular, estando relacionada a adesao de leucocitos no endotelio vascular. Esta alteracao pode estar relacionada ao processo inflamatorio, pois a glicoproteina ICAM e produzida quando ha invasao da parede dos vasos por leucocitos, ou simplesmente estar evidenciando neoformacao vascular por reperfusao de vasos pre-existentes.17,18 CONCLUSAOA luz intensa pulsada constitui boa opcao de tratamento para o fotoenvelhecimento cutaneo, sendo uma tecnica nao-ablativa, segura e eficaz, visto que a melhora clinica observada pelos pacientes encontra paralelo na analise histologica. REFERENCIAS1. Gilchrest BA. 5km aging and photoaging: and overview. J Am Acad Dermatol. 1989;21:610-3. [ Links ]2. Odom RB. Topical tretinoin for the treatment of photo clamaged skin. In: Weelmd RG, editor. Cutaneous surgery. Philadelphia: Saunders; 1994. p.28-9. [ Links ]3. Goldberg DJ, Cutler KB. Nonablative treatment of rhytids with intense pulsed light. Lasers Surg Med. 2000;26:196-200. [ Links ]4. Fitzpatrick TB. Fitzpatrick s reactivity of human skin to solar radiation based on skin phototypes I to V: table 138-5. In: Freedberg IM, Eisen AZ, Wolff K, Austen KF, Golsmith LA, Katz SI, Fitzpatrick TB. Dermatology in general medicine. 15th ed. New York: Mc Graw-Hill; 1999. p.1606. [ Links ]5. Glogau RG. Chemical peeling and aging skin. J Geriatr Dermatol. 1994;2:30-5. [ Links ]6. Goldberg DJ, Silapunt S. Histologic evaluation of a Q-switched Nd:YAG laser in the nonablative treatment of wrinkles. Dermatol Surg. 2001;27:744-6. [ Links ]7. Lee MWC. Combination 532-nm and 1064-nm lasers for noninvasive skin rejuvenation and toning. Arch Dermatol. 2003;139:1265-76. [ Links ]8. Menaker GM, Wrone DA, Willians RM, Moy RL. Treatment of facial rhytids with a nonablative laser: a clinical and histologic study. Dermatol Surg. 1999;25:440-4. [ Links ]9. Fournier N, Dahan S, Barneon G, Diridollou S, Lagarde JM, Gall Y, et al. Nonablative remodeling: clinical, histologic, ultrasound imaging, and profilometric evaluation of a 1540 nm Er:Glass laser. Dermatol Surg. 2001;27:799-806. [ Links ]10. Trelles MA, Allones I, Luna R. Facial rejuvenation with a nonablative 1320 nm Nd:YAG laser: a preliminary clinical and histologic evaluation. Dermatol Surg. 2001;27:111-6. [ Links ]11. Spicer MS, Goldberg DJ. Lasers in dermatology. J Am Acad Dermatol. 1996;34:1-25. [ Links ]12. Kawada A, Shiraishi H, Asai M, Kameyama H, Sangen Y, Aragane Y, et al. Clinical improvement of solar lentigines and ephelides with an intense pulsed light source. Dermatol Surg. 2002;28:504-8. [ Links ]13. Sadick NS. Update on non-ablative light therapy for rejuvenation: a review. Lasers Surg Med. 2003;32:120-8. [ Links ]14. Feng YJ, Zhao JY. Skin rejuvenation in Asian skin: the analysis of clinical effects and basic mechanisms of intense pulsed light. J Drugs Dermatol. 2008;7:273-9. [ Links ]15. Li YH, Wu Y, Chen JZ, Gao XH, Liu M, Shu CM, et al. Application of a new intense pulsed light device in the treatment of photoaging skin in Asian patients. Dermatol Surg. 2008;34:1459-64. [ Links ]16. Salgado AGM. Estudo imuno-histoquimico da pele antes