e com radiacao ionizante (32, 33). A interacao e relatada ser ao menos aditiva (9). Baseado nos achados do caso presente, o efeito da vitamina D pode ser considerada como uma acao independente ou aditiva apos radioterapia.Concluindo, apesar da dificuldade de alcancar conclusoes definitivas a respeito da eficacia da vitamina D em fibromatose agressiva baseado nos achados de um unico paciente, nos temos a opiniao de que seria util conduzir mais estudos neste aspecto.Referencias1. Shields CJ,WinterWO, KirwanWO, Redmond HP. Desmoid tumors. Eur J Surg Oncol 2001;27:7016.2. Nuyttens JJ, Rust FR, Thomas CR, Turrisi AT. Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors. A comparative review of 22 articles. Cancer 2000;88:151723.3. Janinis J, Patriki M, Vini L, et al. The pharmacological treatment of aggressive fibromatosis: a systematic review. Ann Oncol 2003; 14:18190.4. Casado M, Martin M, Munoz A, Bernal J. Vitamin D3 inhibits proliferation and increases c-myc expression in fibroblasts from psoriatic patients. J Endocrinol Invest 1998;21:5205.5. Abe E, Miyaura C, Sakagami H, et al. Differentiation of mouse myeloid leukemia cells induced by 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 1981;76:49904.6. Akther J, Lu I, Finlay M, et al. 1a,25dihydroxy vitamin D3 and its analogues, EB1089 and CB1093, profoundly inhibit the in vitro proliferation of the human hepatoblastoma cell line HEPG2. Aust NZ J Surg 2001;71:4147.7. Akther J, Goerdel M, Morris DL. A vitamin D3 analogue (EB1089) inhibits in vitro cellular proliferation of human colon cancer cells. Br J Surg 1996;83:22930.8. James SY, Mackay AG, Colston KW. Effects of 1,25-dihydroxyvitamin D3 and its analogues on induction of apoptosis in breast cancer cells. Steroid Biochem Mol Biol 1996;58:395401.9. Polar MK, Gennings C, Park M, et al. Effect of the vitamin D3 analog ILX 237553 on apoptosis and sensitivity to fractionated radiation in breast tumor cells and normal human fibroblasts. Cancer Chemother Pharmacol 2003;51:41521.10. Hyodo H, Kimura A, Nakata Y, et al. 1-alpha-Hydroxyvitamin D3 in the treatment of primarymyelofibrosis:in vitro effect of vitamin D3metabolites on the bone marrow fibroblasts. Int J Hematol 1993;57:1317.11. Azzarelli A, Gronchi A, Bertulli R, et al. Low dose chemotherapy with methotrexate and vinblastine for patients with advanced aggressive fibromatosis. Cancer 2001;92:125964.12. Ocuno SH, Edmonson JH. Combination chemotherapy for desmoid tumors. Cancer 2003;97:11345.13. Patel SR, Evans HL, Benjamin RS. Combination chemotherapy in adult desmoid tumors. Cancer 1993;72:32447.14. Jadrijevic D, Mardones E, Lipschutz A. Antifibromatogenic potency of 9-fluoro derivates of progesterone. Nature 1956;178:13947.15. Bruzzone S, Elqueta H, Lipschultz A. Oestrogen-induced fibroids of the thoracic serosa. Br J Cancer 1948;2:26874.16. Tonelli F, Ficari F, Valanzxano R, Brandi ML. Treatment of desmoids and mesenteric fibromatosis in familial adenomatosis poliposis with raloxifene. Tumori 2003;89:3916.17. Brooks MD, Ebbs SR, Colletta AA, et al. Desmoid tumors treated with triphenylenes. Eur J Cancer 1992;28A:10148.18. Lanari A. Effect of progesterone on desmoid tumors (aggressive fibromatosis). N Engl J Med 1983;309:15236.19. Waddell WR, Kirsch WM. Testolactone, sulindac, warfarin and vitamin K1 for unresectable desmoid tumors. Am J Surg 1991;161:41621.20. Waddell WR, Gerner RE. Indomethacin and ascorbate inhibit desmoid tumors. J Surg Oncol 1980;15:8590.21. KleinWA,Miller HH, AndersonM, et al. The use of indomethacin, sulindac and tamoxifen for