Coffee is a popular beverage consumed worldwide and its effect on health protection has been well studied throughout literature. This study investigates the effect of chronic coffee and caffeine ingestion on cognitive behavior and the antioxidant system of rat brains. The paradigms of open field and object recognition were used to assess locomotor and exploratory activities, as well as learning and Memory. The antioxidant system was evaluated by determining the activities of glutathione reductase (GR), glutathione peroxidase (GPx) and superoxide dismutase (SOD), as well as the lipid peroxidation and reduced glutathione content. Five groups of male rats were fed for approximately 80 days with different diets: control diet (CD), fed a control diet; 3% coffee diet (3%Co) and 6% coffee diet (6%Co), both fed a diet containing brewed coffee; 0.04% Caffeine diet (0.04%Ca) and 0.08% caffeine diet (0.08%Ca), both fed a control diet supplemented with caffeine. The estimated caffeine intake was approximately 20 and 40 mg/kg per day, for the 3%Co0.04%Ca and 6%Co 0.08%Ca treatments, respectively. At 90 days of life, the animals were subjected to the behavioral tasks and then sacrificed. The results indicated that the intake of coffee, similar to caffeine, improved long-term memory when tested with object recognition; however, this was not accompanied by an increase in locomotor and exploratory activities. In addition, chronic coffee and caffeine ingestion reduced the lipid peroxidation of brain membranes and increased the concentration of reduced-glutathione. The activities of the GR and SOD were similarly increased, but no change in GPx activity could be observed. Thus, besides improving cognitive function, our data show that chronic coffee consumption modulates the endogenous antioxidant system in the brain. Therefore, chronic coffee ingestion, through the protection of the antioxidant system, may play an important role in preventing age-associated decline in the cognitive function. CLIQUE NO TITULO PARA BAIXAR O ARTIGO COMPLETO Se por um lado o habito de ler rotulos ajuda na dieta, em excesso, pode acabar virando uma doenca. Ler rotulo de comida ajuda a emagrecer A ortorexia, transtorno alimentar caracterizado pela obsessao por comidas saudaveis, e cada vez mais comum, de acordo com a psicanalista Dirce de Sa Freire, coordenadora do curso de especializacao em transtornos alimentares da PUC-RJ. "E resultado de uma cobranca excessiva por uma alimentacao saudavel. Essa historia de olhar rotulos e uma faca de dois gumes. Quem tem tendencia a ter algum disturbio alimentar pode acabar desenvolvendo a doenca", afirma. Um ortorexico precisa ter controle sobre tudo o que come e sempre procura o alimento mais natural, com a menor quantidade de gordura e de calorias. Alem de olhar os rotulos, um ortorexico costuma ler os ingredientes para saber exatamente o que tem no produto. "Percebemos que e um transtorno quando passa a interferir na vida social. A pessoa deixa de ir a certos lugares ou de participar de festas porque la ela nao podera controlar o que come", complementa Freire. A ortorexia pode ser associada a outros disturbios alimentares, como a anorexia. Nos quadros mais graves, a pessoa faz uma "censura alimentar" tao forte que deixa de ingerir alguns grupos de