o cerebro sem deprimir o coracao.Carlos MonteiroP.S.:Um simpatolitico alternativo que deveria merecer uma maior investigacao para o tratamento da hipertensao arterial e da aterosclerose seria a digoxina em baixa dosagem, a qual tambem ira possivelmente oferecer um efeito benefico na reducao do risco de demencia e doenca de Alzheimer (16). A proposito, o tratamento com a digoxina, em doses baixas (< ou = 0,125 mg/dia) provavelmente ira resultar em baixas concentracoes plasmaticas de 0,5-09ng/ml (40). Gheorghiade e colegas, em um estudo retrospectivo de dados a partir do estudo DIG tambem indicaram um efeito benefico da digoxina na morbidade e, sem excesso na mortalidade em mulheres, com concentracoes sericas de 0,5 - 0,9 ng/ml, ao passo que as concentracoes sericas > ou = 1,2ng/ml pareceram nocivas (41).Referencias:1. Silvestrini M, Gobbi B, Pasqualetti P, et al, Carotid atherosclerosis and cognitive decline in patients with Alzheimer's disease. Neurobiol Aging. 2009 Aug;30(8):1177-832. Silvestrini M, Viticchi G, Falsetti L et al The role of carotid atherosclerosis in Alzheimer's disease progression. J Alzheimers Dis. 2011;25(4):719-263. Wendell CR, Waldstein SR, Ferrucci L, O'Brien RJ, Strait JB, Zonderman AB. Carotid atherosclerosis and prospective risk of dementia. Stroke. 2012 Dec;43(12):3319-244. Alzheimers Solved (Condensed Edition), 2006, by Henry Lorin5. de la Torre JC, Mussivand T. Can disturbed brain microcirculation cause Alzheimers disease? Neurological Research. 1993;15(3):1461536. de la Torre JC. Cardiovascular Risk Factors Promote Brain Hypoperfusion Leading to Cognitive Decline and Dementia. Cardiovasc Psychiatry Neurol. 2012; 2012: 367516.Full free text at http://www.hindawi.com/journals/cpn/2012/367516/ 7. Kennely SP, Lawlor BA and Kenny RA. Blood pressure and the risk of dementia: a double edged sword. Ageing Res Rev. 2009 Apr;8(2)8. Peila R, White LR, Masaki K, Petrovitch H, Launer LJ. Reducing the risk of dementia: efficacy of long-term treatment of hypertension. Stroke 2006;37:11651170. Full free text at http://stroke.ahajournals.org/content/37/5/1165.long9. Guan JW, Huang CQ, Li YH, Wan CM, You C, Wang ZR, Liu YY, Liu QX. No association between hypertension and risk for Alzheimer's disease: a meta-analysis of longitudinal studies. J Alzheimers Dis. 2011;27(4):799-807.10. McGuinness B, Todd S, Passmore P, Bullock R. Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD004034.11. Kuyumcu ME, Yesil Y, Ozturk ZA, Halil M, Ulger Z et al. Alzheimer's disease is associated with a low prevalence of hypertension. Dement Geriatr Cogn Disord. 2012;33(1):6-10. 12. Medical News Today, Do Beta-Blockers Reduce Dementia Risk? 08 Jan 201313. American Academy of Neurology. Can Blood Pressure Drugs Reduce the Risk of Dementia? January 7, 2012 at http://www.aan.com/press/index.cfm?fuseaction=release.view&release=1127 14. White L, Gelber R. Launer T et al. Beta Blocker Treatment of Hypertensive Older Persons Ameliorates the Brain Lesions of Dementia Measured at Autopsy: The Honolulu- Asia Aging Study"; Author/presenter: Lon White; abstract due to be presented 21 March 2013, abstract 2171, at AAN 65th Annual Meeting, San Diego.15. Susan Hughes, Beta-blockers linked to fewer Alzheimers lesions. Heartwire, January 8, 2012. 16. Carlos ETB Monteiro, Ambiente acido evocado por estresse cronico: Um novo mecanismo para explicar a aterogenese", 28 de janeiro de 2008 em http://www.infarctcombat.org/AcidityTheory-p.pdf17. Idiaquez J, Roman GC et al. Autonomic dysfunction in neurodegenerative dementias.