Metabolitos secundarios no extrato etanolico das folhas de Solanum monachophyllum Dunal e seupotencial fungicida sobre Candida albicans in vitroSecondary metabolitesin the ethanol extract of leaves of Solanum monachophyllum Dunal and its potential fungicidal against Candida albicans in vitroValdicleiaAlves Ferreira1, Renato Abreu Lima2*1Graduacao em Ciencias Biologicas,Faculdade Sao Lucas, Porto Velho, RO, Brasil; 2Departamento deCiencias Biologicas, Faculdade Sao Lucas, Porto Velho, RO, Brasil. *E-mail: renatoabreu07@hotmail.comRESUMOEstetrabalho teve como objetivo identificar os metabolitossecundarios do extrato etanolico das folhas de Solanum monachophyllum Dunal e avaliar sua atividade fungicidasobre C. albicans in vitro, uma planta pouco estudada. A coleta das folhas foirealizada na area urbana, regiao central, em Porto Velho-RO. Apos a coleta foipesado fresco e ficou na estufa por tres dias na temperatura de 50oC. O materialpassou pelo processo de destilacao e obtencao do extrato bruto vegetal. A partir do extrato bruto das folhas, foramrealizados testes fitoquimicos e microbiologico. A avaliacaoconsistiu em medir o diametro das colonias iniciadas apos 24 horas deincubacao. Sendo que a partir das 72horas, o extrato da planta apresentou acaode inibicao em relacao as os outros tratamentos. E os dados obtidos com ostestes microbiologicos passaram por analise de variancia e as medias comparadaspelo teste de Tukey a 5% de probabilidade. Observou-se que esta plantaapresentou os seguintes metabolitos secundarios: alcaloides,cumarinas, flavonoides, saponinas e derivados antracenicos livres. Verificou-seque o extrato etanolico das folhas de S.monachophyllum apresentou inibicao decrescimento sobre C. albicans,notando-se que no final de cinco dias, a media de inibicao das colonias dosfungos utilizando o extrato vegetal foi de 2,08mm; no controle positivo,utilizando a agua destilada esteril, a media foi de 4,72mm, enquanto que nocontrole negativo, utilizando o produto quimico, a inibicao media foi de2,93mm. Porem, outras metodologias devem ser testadas para verificar apotencialidade fungicida no extrato etanolico de S. monachophyllum. PALAVRAS-CHAVE:Solanaceae,Jurubebinha, Amazonia, Acao Candidacida.ABSTRACTThis study aimed to identify the secondary metabolites of ethanol extract ofleaves of Solanum monachophyllumDunal and evaluate their fungicidal activity against C. albicans in vitro, a plant understudied. The collection ofleaves was carried out in the urban area, central region, in Porto Velho-RO.After the collection was weighed fresh and stayed in the oven for three days at50 o C. The material passed through the distillation plant and obtaining thecrude extract process. From the crude extract of the leaves, phytochemicals andmicrobiological tests were performed. The evaluation consisted of measuring thediameter of the colonies commenced after 24 hours of incubation. Being that asof 72 hours, the plant extract showed inhibitory action in relation to theother treatments. And data obtained with microbiological tests passed byanalysis of variance and means were compared by Tukey test at 5% probability.It was observed that this plant showed the following secondary metabolites:alkaloids, coumarins, flavonoids, saponins and free antracenicos derivatives.It was found that the ethanolic extract of S.monachophyllum showed growth inhibition of C. albicans, noting that at the end of five days, the averageinhibition of fungal colonies using the plant extract was 2.08 mm; the positivecontrol, using sterile distilled water, the mean was 4.72 mm, while thenegative control using the chemical, the average inhibition was 2.93 mm. However,other methods must be tested to verify the capability fungicide in ethanolextract