http://www.ufrgs.br/actavet/44-suple-1/CR_150.pdfActa Scientiae Veterinariae, 2016. 44(Suppl 1): 150Rafael Oliveira Chaves , Bruna Copat , Joao Pedro Scussel Feranti , Denis Antonio Ferrarin, Marcelo LuisSchwab , Luciana Schneider , Raqueli Teresinha Franca & Alexandre Mazzanti Secondary neurological disorders to hypothyroidism are unusual in dogs, especially when compared with otherclinical signs, such as lethargy, weight gain and dermatological alterations. When manifested, these signals refer to theperipheral or central nervous system and the most common include: vestibular disease, seizures, laryngeal paralysis, polyneuropathyand paralysis of the facial nerve. Several reports of neurological disorders associated with hypothyroidism arefound in literature. In the national literature, however, there are few reports on the subject. Thus,the aim of this study was to report a case of facial paralysis associated with hypothyroidism in a dog. A 7-year-old canine, male boxer, was referred to the Veterinary Medical Teaching Hospital of theUFSM with a history of difficult water and food intake and asymmetry of the face for seven days. On neurological examination,the animal was alert and with normal locomotion, postural reactions and segmental reflexes. Inthe evaluation of the cranial nerves, there was a menace response absent the right side, however with preserved vision. There was palpebral and lip ptosis of the right side and absence of palpebral reflex on the same side. The diagnosis of facial paralysis associated with hypothyroidism was based on the history, clinical andneurological examination findings, laboratory assessment of thyroid function by observing low serum free T4 and highconcentrations of TSH, the therapeutic response after supplementation levothyroxine sodium, and exclusion of other possiblecauses, such as otitis interna and traumatic. The pathogenesis of this change associated with hypothyroidism is notcompletely understood, although it is believed that cranial nerve paralysis (trigeminal, facial and vestibulocochlear) mayresult from the resulting compression of myxedema deposit nerve or in the tissues of the head and neck, demyelinationcaused by disordered metabolism of Schwann cells, decreased blood perfusion of the inner ear secondary to hyperlipidemiaand increased blood viscosity or metabolic defects ranging from change in axonal transport to severe axonal loss. Treatmentconsists of supplementation of levothyroxine and most dogs with neurological disorders associated with hypothyroidismwill present partial or total improvement of clinical signs between two and four months, generally being observed improvementwithin the first week of treatment. In the dog this report, after the beginning of treatment, improvement was observedpartial and total clinical signs in 15 and 32 days, respectively. Therefore, with appropriate treatment, hypothyroidism is adisease with an excellent prognosis. The report brings to clinical relevance, the importance of hypothyroidism in the differentialdiagnosis of facial paralysis in dogs with face asymmetry history, the laboratory evaluation of thyroid functionand response to therapy with levothyroxine sodium supplementation essential for definitive diagnosis Veterinaria e Zootecnia, 2016 mar.;23(1): 38-48.Carolina Lechinski de Paula,Carmen Daza Bolanos & Marcio Garcia Ribeirohttp://www.fmvz.unesp.br/rvz/index.php/rvz/article/view/819/684RESUMO O botulismo e uma enfermidade causada pela ingestao de toxinas produzidas pelo Clostridiumbotulinum, bacteria gram-positiva, anaerobica e formadora de esporos, que esta amplamentedistribuida na natureza, no solo e em sedimentos de lagos e mares. Em caes, a doenca ocorreprincipalmente pela ingestao da toxina pre-formada presente em alimentos deteriorados oucarcacas em decomposicao. Apos a absorcao,