the subject. The searchfor texts was not exhaustive and therefore we know that there may be relevanttexts that are not listed below. So over the next few months, other texts maybe added, appropriately highlighted as new.Finally, weremind the reader that national regulatory frameworks should not regulate atechnology, but their products. In fact, each product carries its risks andbenefits, even if produced by the same technology. The serious mistake manycountries committed regulating the technology, rather than the product, shouldnot be repeated again. We also recall that the risk assessment conceptual basis,as established for GMOs, probably will suffice for a careful and responsible riskassessment of products arising from any other technology, especially the CRISPRsystem / Cas9.A. Selected texts on genome editing issuesA1. Texts describing the technology and generalissuesBhaya D, Davison M, Barrangou R, 2011. CRISPR-Cas Systems in Bacteria and Archaea:Versatile small RNAs for adaptive defense and regulation. Annu. Rev. Genet.45:27397. http://www.ncbi.nlm.nih.gov/pubmed/22060043 Anonymous,2016. CRISPR/Cas9 Guide. https://www.addgene.org/crispr/guide/ Medina-Aparicio L, Rebollar-Flores JE, Gallego-Hernandez AL,Vazquez A, Olvera L, Gutierrez-Rios RM, Calva E, Hernandez-Lucas I, 2011. The CRISPR/Cas Immune System Is anOperon Regulated by LeuO, H-NS, and Leucine-Responsive Regulatory Protein inSalmonella enterica Serovar Typhi. J. Bacteriol. 193(10): 2396-2407. http://jb.asm.org/content/193/10/2396.full Ran FA, Hsu PD, JWright J, AgarwalaV, Scott DA, Zhang F, 2013. Genome engineering using the CRISPR-Cas9 system. Nature Protocols 8(11): 2281-2308 doi:10.1038/nprot.2013.143. A2. Texts on regulatory and ethical issues(risk assessment, risk analysis, legal framework, etc.)Jasanoff S,Hurlbut JB, Saha K, 2015. "CRISPR Democracy: Gene Editing and the Need forInclusive Deliberation." Issues in Science and Technology 32, no. 1 (Fall2015). http://issues.org/32-1/crispr-democracy-gene-editing-and-the-need-for-inclusive-deliberation/ Hoffman S,2016. CRISPR: The GMO technology that needs no regulation, says USDA. OrganicConsumers Association. https://www.organicconsumers.org/news/crisprgmotechnologyneedsnoregulationsaysusda Entine J, 2015. Ethical andregulatory reflections on CRISPR gene editing revolution. Genetic LiteracyProject, https://www.geneticliteracyproject.org/2015/06/25/ethical-and-regulatory-reflections-on-crispr-gene-editing-revolution/ Magnus D,Martinez N, 2016. In Embryo research we need laws first, then science. http://time.com/4204059/crisprregulation/ Caplan AL, Parent B, Shen M,Plunkett C, 2015. No time to wastethe ethical challenges created by CRISPR. EMBOreports 16(11): 1421-1426. http://embor.embopress.org/content/16/11/1421.long The ThirdWorld Network, 2016. Gene Editing: In Urgent Need of Regulation. http://www.biosafetyinfo.net/article.php?aid=1216 B. Selected texts on gene drive issuesB1. Texts describing the technology and generalissuesAnonymous,2016. A review of the safety & efficacy of genetically engineered mosquitoes.Effective Altruism Forum. http://effective-altruism.com/ea/tp/a_review_of_the_safety_efficacy_of_genetically/ Hammond A,Galizi R, Kyrou K, Simoni A, Siniscalchi C, Katsanos D, Gribble M, Baker D,Marois E, Russell S, Burt A, Windbichler N, Crisanti A, Nolan T, 2016. ACRISPR-Cas9 gene drive system targeting female reproduction in the malariamosquito vector Anopheles gambiae.Nat Biotechnol. 34(1):78-83. http://www.ncbi.nlm.nih.gov/pubmed/26641531 Esvelt KM, Smidler AL, CatterucciF, Church GM, 2014. ConcerningRNA-guided gene drives for the alteration of wild populations. eLife 2014;3:e03401. https://elifesciences.org/content/3/e03401v3 Sinkins SP, Gould F, 2006. Genedrive systems for insect disease vectors. NATUREREVIEWS, GENETICS, 7: 427-435. http://www.nature.com/nrg/journal/v7/n6/full/nrg1870.html Gantz VM,Jasinskiene N, Tatarenkova O, Fazekas A, Macias VM, Bier E, James AA, 2015. Highlyefficient Cas9-mediated gene drive for population modification of the malariavector mosquito Anopheles stephensi. Proc Natl Acad Sci U S A. 112(49):E6736-43. http://www.ncbi.nlm.nih.gov/pubmed/26598698 Akbari OS,Matzen KD, John M. Marshal JM, Huang H, Ward CM, Hay BA, 2013. A synthetic genedrive system for local, reversible modification and suppression of insect populations.Current Biology 23: 671677. http://dx.doi.org/10.1016/j.cub.2013.02.059 MarshallJM, Hay BA, 2014. Medusa: A Novel Gene Drive System for