S10 2JF, Reino Unido2 Departamento de Neurologia, Royal Hallamshire Hospital, SheffieldCorrespondencia para: Aziz imran.aziz@sth.nhs.ukColaboradores: todos os autores redigiram o texto e aprovaram a versao final. DSS e o avalista do artigo.Conflitos de interesse: todos os autores preencheram o formulario unificado de conflitos de interesse em www.icmje.org/coi_disclosure.pdf (disponivel apos solicitacao do autor correspondente) e declaram que: nao receberam nenhum apoio financeiro para o trabalho submetido; DSS recebeu uma bolsa de estudos de Dr. Schar (um fabricante de alimentos livre de gluten) para realizar pesquisas sobre a sensibilidade ao gluten; os autores nao mantem outras relacoes ou exercem atividade que possam ter influenciado o trabalho submetido.Procedencia: contribuicao espontanea.Revisao por pares: externa.Referencias1 Sanders DS, Patel D, Stephenson TJ, Ward AM, McCloskey EV, et al. A primary care cross-sectional study of undiagnosed adult coeliac disease. Eur J Gastroenterol Hepatol 2003;15:407-13.2 Hopper AD, Hadjivassiliou M, Butt S, Sanders DS. Adult coeliac disease. BMJ 2007;335:558-62.3 Hopper AD, Cross SS, Hurlstone DP, McAlindon ME, Lobo AJ, et al. Pre-endoscopy serological testing for coeliac disease: evaluation of a clinical decision tool. BMJ 2007;334:729.4 Painter K. Gluten-free diets gaining in popularity. USA Today 2008 Aug 17.5 Di Sabatino A, Corazza GR. Nonceliac gluten sensitivity: sense or sensibility? Ann Intern Med 2012;156:309-11.6 Rubio-Tapia A, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE. The prevalence of celiac disease in the United States. Am J Gastroenterol 2012;107:1538-447 Tanpowpong P, Ingham TR, Lampshire PK, Kirchberg FF, Epton MJ, et al. Coeliac disease and gluten avoidance in New Zealand children. Arch Dis Child 2012;97:12-6.8 Ferch CC, Chey WD. Irritable bowel syndrome and gluten sensitivity without celiac disease: separating the wheat from the chaff. Gastroenterology 2012;142:664-6.9 Verdu EF, Armstrong D, Murray JA. Between celiac disease and irritable bowel syndrome: the no mans land of gluten sensitivity. Am J Gastroenterol 2009;104:1587-94.10 Kaukinen K, Turjanmaa K, Maki M, Partanen J, Venalainen R, et al. Intolerance to cereals is not specific for coeliac disease. Scand J Gastroenterol 2000;35:942-6.11 Sanders DS, Carter MJ, Hurlstone DP, Pearce A, Ward AM, et al. Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care. Lancet 2001;358:1504-8.12 Carroccio A, Mansueto P, Iacono G, Soresi M, DAlcamo A, et al. Non-celiac wheat sensitivity diagnosed by double-blind placebocontrolled challenge: exploring a new clinical entity. Am J Gastroenterol (forthcoming).13 Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012;10:13.14 Volta U, De Giorgio R. New understanding of gluten sensitivity. Nat Ver Gastroenterol Hepatol 2012;9:295-9.15 Volta U, Tovoli F, Cicola R, Parisi C, Fabbri A, Piscaglia M, et al. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol 2012;46:680-5.16 Sapone A, Lammers KM, Mazzarella G, Mikhailenko I, Carteni M, et al. Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease. Int Arch Allergy Immunol 2010;152:75-80.17 Sapone A, Lammers KM, Casolaro V, Cammarota M, Giuliano MT, et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and