disorders affected patients usually have two copies of a disease gene (or mutation) in order to show symptoms. People with only one copy of the disease gene (called carriers) generally do not show signs or symptoms of the condition but can pass the disease gene to their children. When both parents are carriers of the disease gene for a particular disorder, there is a 25% chance with each pregnancy that they will have a child affected with the disorder. As with all genetic diseases, genetic counseling may be appropriate to help families understand recurrence risks and ensure that they receive proper evaluation and care.ReferencesFrerman, F.E. and Goodman, S.I. Defects of Electron Transfer Flavoprotein and Electron Transfer Flavoprotein-Ubiquinone Oxidoreductase. In, The Metabolic and Molecular Basis of Inherited Disease. 8th Edition, 2001. Scriver, Beaudet, et al. McGraw-Hill. Chapter 103, pg. 2357 - 2365.Goodman, S.I., Reale, M. and Berlow, S. Glutaric acidemia type II: A form with deleterious intrauterine effects. J Pediatrics 102:411, 1983.Goodman, S.I., Stene, D.O., McCabe, E.R.B, et al. Glutaric aciduria type II: Clinical, biochemical and morphologic considerations. J Pediatrics 100:946, 1982. Harpey, J.P., Charpentier, C., Goodman, S.I., et al. Multiple acyl-CoA dehydrogenase deficiency occurring in pregnancy and caused by a defect in riboflavin metabolism in the mother. J Pediatrics 103:394, 1983.Mitchell, G., Saudubray, J.M., Gubler, M.C., et al. Congenital anomalies in Glutaric aciduria type 2. J Pediatrics 104:961, 1984.Stockler, S., Radner, H., Felizitas, K., et al. Symmetric hypoplasia of the temporal cerebral lobes in an infant with Glutaric aciduria type II (multiple acyl-CoA dehydrogenase deficiency). J Pediatrics 124:601, 1994.Sweetman, L., Nyhan, W.L., Trauner, D.A., et al. Glutaric aciduria type II. J Pediatrics 96:1020, 1980. Web SitesSaveBabies.orgSite established and maintained by parents of newborns affected with a rare genetic defect, with information for parents and professionals and links to other informative sites.National Newborn Screening and Genetics Resource CenterProvides information and resources in the area of newborn screening and genetics to benefit health professionals, the public health community, consumers and government officials.DisclaimersThe analyses conducted by PerkinElmer Genetics produce results that can be used by qualified physicians in the diagnosis of disorders described herein. Evidence of these conditions will be detected in the vast majority of affected individuals; however, due to genetic variability, age of the patient at the time of specimen collection, quality of the specimen, health status of the patient, and other variables, such conditions may not be detected in all affected patients. PerkinElmer Genetics makes no warranty whatsoever, express or implied, including any warranty as to accuracy, completeness or timeliness, concerning the information contained herein, and you should not assume that such information is complete or the most up-to-date information available. PerkinElmer Genetics shall not be liable for any loss, claim or damages caused in whole or in part by our provision of, or your use of, any of the information contained herein. As a general statement, this information was drawn from published literature and is not drawn from our patient population or screening experience. The information contained herein is not intended to be a substitute for professional medical advice and should